| 1976-04-09 | @ BAL | 1 | L 0-1 | 0-1 | 3 | 46,425 | Fergie Jenkins | Jim Palmer | Jim Palmer | Fergie Jenkins | Dyar Miller | 0 | 1 | -1 |
| 1976-04-10 | @ BAL | 2 | L 1-5 | 0-2 | 5 | 8,899 | Rick Wise | Ken Holtzman | Ken Holtzman | Tom House | | 1 | 6 | -5 |
| 1976-04-11 | @ BAL | 3 | W 6-2 | 1-2 | 5 | 13,418 | Luis Tiant | Mike Cuellar | Luis Tiant | Mike Cuellar | | 7 | 8 | -1 |
| 1976-04-13 | vs CLE | 4 | W 7-4 | 2-2 | 3 | 32,127 | Bill Lee | Pat Dobson | Reggie Cleveland | Pat Dobson | | 14 | 12 | 2 |
| 1976-04-14 | vs CLE | 5 | L 5-6 | 2-3 | 5 | 14,315 | Fergie Jenkins | Jim Bibby | Don Hood | Fergie Jenkins | Dave LaRoche | 19 | 18 | 1 |
| 1976-04-15 | vs CHA | 6 | L 4-8 | 2-4 | 5 | 10,916 | Rick Wise | Bart Johnson | Bart Johnson | Rick Wise | Clay Carroll | 23 | 26 | -3 |
| 1976-04-17 | vs CHA | 7 | W 7-1 | 3-4 | 5 | 24,328 | Luis Tiant | Terry Forster | Luis Tiant | Rich Gossage | | 30 | 27 | 3 |
| 1976-04-18 | vs CHA | 8 | L 4-10 | 3-5 | 5 | 18,971 | Bill Lee | Wilbur Wood | Wilbur Wood | Bill Lee | | 34 | 37 | -3 |
| 1976-04-19 | vs MIN | 9 | W 2-0 | 4-5 | 4 | 34,158 | Fergie Jenkins | Joe Decker | Fergie Jenkins | Joe Decker | | 36 | 37 | -1 |
| 1976-04-20 | vs MIN | 10 | W 12-3 | 5-5 | 3 | 22,147 | Rick Wise | Dave Goltz | Rick Wise | Dave Goltz | | 48 | 40 | 8 |
| 1976-04-23 | @ CHA | 11 | W 9-2 | 6-5 | 4 | 11,920 | Luis Tiant | Wilbur Wood | Luis Tiant | Wilbur Wood | | 57 | 42 | 15 |
| 1976-04-29 | @ TEX | 12 | L 1-6 | 6-6 | 4 | 7,394 | Bill Lee | Nelson Briles | Nelson Briles | Bill Lee | | 58 | 48 | 10 |
| 1976-04-30 | @ TEX | 13 | L 5-6 | 6-7 | 5 | 14,471 | Fergie Jenkins | Jim Umbarger | Jim Umbarger | Fergie Jenkins | Joe Hoerner | 63 | 54 | 9 |
| 1976-05-01 | @ TEX | 14 | L 1-7 | 6-8 | 5 | 22,486 | Rick Wise | Bill Singer | Bill Singer | Rick Wise | | 64 | 61 | 3 |
| 1976-05-02 | @ TEX | 15 | L 3-6 | 6-9 | 6 | 24,464 | Luis Tiant | Gaylord Perry | Gaylord Perry | Luis Tiant | | 67 | 67 | 0 |
| 1976-05-04 | vs KCA | 16 | L 5-7 | 6-10 | 6 | 16,274 | Bill Lee | Al Fitzmorris | Al Fitzmorris | Bill Lee | Doug Bird | 72 | 74 | -2 |
| 1976-05-05 | vs KCA | 17 | L 4-8 | 6-11 | 6 | 17,596 | Fergie Jenkins | Paul Splittorff | Paul Splittorff | Fergie Jenkins | Mark Littell | 76 | 82 | -6 |
| 1976-05-08 | vs TEX | 18 | L 5-6 | 6-13 | 6 | 0 | Rick Wise | Bill Singer | Steve Hargan | Dick Pole | Joe Hoerner | 81 | 88 | -7 |
| 1976-05-08 | vs TEX | 19 | L 4-12 | 6-13 | 6 | 23,737 | Luis Tiant | Jim Umbarger | Jim Umbarger | Luis Tiant | | 85 | 100 | -15 |
| 1976-05-09 | vs TEX | 20 | L 5-6 | 6-14 | 6 | 18,618 | Bill Lee | Gaylord Perry | Steve Foucault | Jim Willoughby | | 90 | 106 | -16 |
| 1976-05-11 | @ CLE | 21 | L 3-4 | 6-15 | 6 | 3,832 | Fergie Jenkins | Pat Dobson | Pat Dobson | Fergie Jenkins | Stan Thomas | 93 | 110 | -17 |
| 1976-05-12 | @ CLE | 22 | W 6-4 | 7-15 | 6 | 4,923 | Rick Wise | Jackie Brown | Tom House | Dave LaRoche | | 99 | 114 | -15 |
| 1976-05-13 | @ CLE | 23 | W 7-5 | 8-15 | 6 | 5,783 | Luis Tiant | Jim Kern | Luis Tiant | Jim Kern | | 106 | 119 | -13 |
| 1976-05-14 | vs MIL | 24 | W 2-1 | 9-15 | 6 | 25,069 | Dick Pole | Pete Broberg | Dick Pole | Pete Broberg | Jim Willoughby | 108 | 120 | -12 |
| 1976-05-15 | vs MIL | 25 | W 9-4 | 10-15 | 6 | 26,327 | Fergie Jenkins | Jim Colborn | Fergie Jenkins | Eduardo Rodriguez | | 117 | 124 | -7 |
| 1976-05-16 | vs MIL | 26 | L 5-11 | 10-16 | 6 | 28,814 | Rick Wise | Jim Slaton | Jim Slaton | Rick Wise | | 122 | 135 | -13 |
| 1976-05-17 | @ DET | 27 | W 7-0 | 11-16 | 6 | 11,757 | Luis Tiant | Joe Coleman | Luis Tiant | Joe Coleman | | 129 | 135 | -6 |
| 1976-05-18 | @ DET | 28 | W 5-3 | 12-16 | 6 | 10,642 | Dick Pole | Vern Ruhle | Jim Willoughby | Jim Crawford | Tom House | 134 | 138 | -4 |
| 1976-05-19 | @ DET | 29 | W 9-2 | 13-16 | 4 | 13,252 | Fergie Jenkins | Dave Roberts | Fergie Jenkins | Dave Roberts | | 143 | 140 | 3 |
| 1976-05-20 | @ NYA | 30 | W 8-2 | 14-16 | 3 | 28,418 | Bill Lee | Ed Figueroa | Reggie Cleveland | Ed Figueroa | Tom House | 151 | 142 | 9 |
| 1976-05-21 | @ NYA | 31 | L 5-6 | 14-17 | 4 | 42,342 | Luis Tiant | Dock Ellis | Sparky Lyle | Jim Willoughby | | 156 | 148 | 8 |
| 1976-05-22 | @ NYA | 32 | L 0-1 | 14-18 | 4 | 43,513 | Dick Pole | Catfish Hunter | Catfish Hunter | Tom House | | 156 | 149 | 7 |
| 1976-05-23 | @ NYA | 33 | W 7-6 | 15-18 | 3 | 52,994 | Fergie Jenkins | Rudy May | Reggie Cleveland | Sparky Lyle | | 163 | 155 | 8 |
| 1976-05-24 | vs DET | 34 | W 3-0 | 16-18 | 3 | 20,590 | Rick Wise | Dave Roberts | Rick Wise | Dave Roberts | | 166 | 155 | 11 |
| 1976-05-25 | vs DET | 35 | W 2-0 | 17-18 | 3 | 21,033 | Luis Tiant | Mark Fidrych | Luis Tiant | Mark Fidrych | | 168 | 155 | 13 |
| 1976-05-26 | @ MIL | 36 | L 2-6 | 17-19 | 3 | 11,496 | Dick Pole | Jim Slaton | Jim Slaton | Dick Pole | | 170 | 161 | 9 |
| 1976-05-27 | @ MIL | 37 | W 2-1 | 18-19 | 3 | 14,308 | Fergie Jenkins | Pete Broberg | Fergie Jenkins | Pete Broberg | | 172 | 162 | 10 |
| 1976-05-28 | vs BAL | 38 | L 1-4 | 18-20 | 3 | 33,250 | Reggie Cleveland | Wayne Garland | Wayne Garland | Reggie Cleveland | Grant Jackson | 173 | 166 | 7 |
| 1976-05-29 | vs BAL | 39 | L 2-7 | 18-21 | 4 | 33,238 | Luis Tiant | Jim Palmer | Jim Palmer | Luis Tiant | | 175 | 173 | 2 |
| 1976-05-30 | vs BAL | 40 | W 3-1 | 19-21 | 3 | 28,300 | Rick Wise | Doyle Alexander | Rick Wise | Doyle Alexander | | 178 | 174 | 4 |
| 1976-05-31 | vs NYA | 41 | L 3-8 | 19-22 | 4 | 35,939 | Fergie Jenkins | Catfish Hunter | Catfish Hunter | Fergie Jenkins | | 181 | 182 | -1 |
| 1976-06-02 | vs NYA | 42 | L 2-7 | 19-23 | 5 | 30,110 | Dick Pole | Ed Figueroa | Ed Figueroa | Dick Pole | | 183 | 189 | -6 |
| 1976-06-03 | vs NYA | 43 | W 8-2 | 20-23 | 4 | 29,505 | Luis Tiant | Dock Ellis | Luis Tiant | Dock Ellis | | 191 | 191 | 0 |
| 1976-06-04 | vs CAL | 44 | L 4-5 | 20-24 | 4 | 23,154 | Rick Wise | Don Kirkwood | Mickey Scott | Jim Willoughby | Dick Drago | 195 | 196 | -1 |
| 1976-06-05 | vs CAL | 45 | W 4-3 | 21-24 | 4 | 25,784 | Fergie Jenkins | Frank Tanana | Fergie Jenkins | Frank Tanana | | 199 | 199 | 0 |
| 1976-06-06 | vs CAL | 46 | W 4-1 | 22-24 | 3 | 26,003 | Dick Pole | Nolan Ryan | Dick Pole | Nolan Ryan | Reggie Cleveland | 203 | 200 | 3 |
| 1976-06-08 | vs OAK | 47 | L 5-6 | 22-25 | 3 | 26,704 | Luis Tiant | Paul Mitchell | Jim Todd | Reggie Cleveland | Rollie Fingers | 208 | 206 | 2 |
| 1976-06-09 | vs OAK | 48 | W 6-4 | 23-25 | 2 | 24,191 | Rick Wise | Mike Torrez | Rick Wise | Mike Torrez | Tom House | 214 | 210 | 4 |
| 1976-06-10 | vs OAK | 49 | L 5-8 | 23-26 | 2 | 27,364 | Fergie Jenkins | Stan Bahnsen | Jim Todd | Tom Murphy | Rollie Fingers | 219 | 218 | 1 |
| 1976-06-11 | @ MIN | 50 | L 4-10 | 23-27 | 3 | 15,766 | Dick Pole | Bill Singer | Tom Burgmeier | Dick Pole | | 223 | 228 | -5 |
| 1976-06-12 | @ MIN | 51 | W 5-2 | 24-27 | 3 | 10,812 | Luis Tiant | Dave Goltz | Luis Tiant | Dave Goltz | | 228 | 230 | -2 |
| 1976-06-13 | @ MIN | 52 | W 10-2 | 25-27 | 3 | 22,146 | Rick Jones | Jim Hughes | Rick Jones | Jim Hughes | | 238 | 232 | 6 |
| 1976-06-14 | @ MIN | 53 | W 5-0 | 26-27 | 3 | 6,820 | Rick Wise | Joe Decker | Rick Wise | Joe Decker | | 243 | 232 | 11 |
| 1976-06-15 | @ OAK | 54 | L 2-3 | 26-28 | 3 | 11,306 | Fergie Jenkins | Glenn Abbott | Paul Lindblad | Fergie Jenkins | | 245 | 235 | 10 |
| 1976-06-16 | @ OAK | 55 | L 1-4 | 26-29 | 3 | 5,925 | Luis Tiant | Paul Mitchell | Paul Mitchell | Luis Tiant | | 246 | 239 | 7 |
| 1976-06-17 | @ OAK | 56 | W 8-3 | 27-29 | 3 | 8,163 | Dick Pole | Mike Torrez | Dick Pole | Mike Torrez | | 254 | 242 | 12 |
| 1976-06-18 | @ CAL | 57 | W 3-1 | 28-29 | 2 | 16,568 | Rick Jones | Don Kirkwood | Tom Murphy | Andy Hassler | | 257 | 243 | 14 |
| 1976-06-19 | @ CAL | 58 | L 3-5 | 28-30 | 4 | 28,686 | Rick Wise | Nolan Ryan | Nolan Ryan | Rick Wise | | 260 | 248 | 12 |
| 1976-06-20 | @ CAL | 59 | W 4-3 | 29-30 | 4 | 17,597 | Fergie Jenkins | Sid Monge | Tom Murphy | Dick Drago | | 264 | 251 | 13 |
| 1976-06-21 | @ BAL | 60 | L 0-2 | 29-31 | 4 | 18,940 | Luis Tiant | Wayne Garland | Wayne Garland | Luis Tiant | | 264 | 253 | 11 |
| 1976-06-22 | @ BAL | 61 | W 6-5 | 30-31 | 4 | 23,577 | Dick Pole | Rudy May | Reggie Cleveland | Dave Pagan | | 270 | 258 | 12 |
| 1976-06-23 | @ BAL | 62 | L 2-3 | 30-32 | 4 | 23,357 | Rick Jones | Jim Palmer | Jim Palmer | Jim Willoughby | | 272 | 261 | 11 |
| 1976-06-24 | vs DET | 63 | L 3-6 | 30-33 | 4 | 26,293 | Rick Wise | Mark Fidrych | Mark Fidrych | Rick Wise | | 275 | 267 | 8 |
| 1976-06-25 | vs DET | 64 | L 2-6 | 30-34 | 5 | 27,942 | Fergie Jenkins | Vern Ruhle | John Hiller | Fergie Jenkins | | 277 | 273 | 4 |
| 1976-06-26 | vs DET | 65 | W 2-1 | 31-34 | 4 | 28,520 | Luis Tiant | Dave Roberts | Luis Tiant | Dave Roberts | | 279 | 274 | 5 |
| 1976-06-27 | vs DET | 66 | L 2-4 | 31-35 | 5 | 29,809 | Dick Pole | Frank MacCormack | Steve Grilli | Tom Murphy | | 281 | 278 | 3 |
| 1976-06-28 | vs BAL | 67 | W 12-8 | 32-35 | 5 | 27,648 | Rick Jones | Jim Palmer | Fergie Jenkins | Mike Flanagan | | 293 | 286 | 7 |
| 1976-06-29 | vs BAL | 68 | W 2-0 | 33-35 | 5 | 30,054 | Rick Wise | Mike Cuellar | Rick Wise | Mike Cuellar | | 295 | 286 | 9 |
| 1976-06-30 | vs BAL | 69 | W 6-4 | 34-35 | 3 | 29,348 | Luis Tiant | Wayne Garland | Jim Willoughby | Wayne Garland | | 301 | 290 | 11 |
| 1976-07-01 | @ MIL | 70 | L 5-6 | 34-36 | 4 | 16,182 | Fergie Jenkins | Jim Slaton | Danny Frisella | Reggie Cleveland | | 306 | 296 | 10 |
| 1976-07-02 | @ MIL | 71 | W 3-0 | 35-36 | 3 | 13,744 | Dick Pole | Jerry Augustine | Dick Pole | Jerry Augustine | Jim Willoughby | 309 | 296 | 13 |
| 1976-07-03 | @ MIL | 72 | L 2-6 | 35-37 | 4 | 21,331 | Rick Jones | Jim Colborn | Jim Colborn | Reggie Cleveland | | 311 | 302 | 9 |
| 1976-07-04 | @ MIL | 73 | W 3-1 | 36-37 | 3 | 13,552 | Rick Wise | Pete Broberg | Rick Wise | Pete Broberg | | 314 | 303 | 11 |
| 1976-07-05 | vs CHA | 74 | W 11-2 | 37-37 | 2 | 24,640 | Luis Tiant | Jesse Jefferson | Luis Tiant | Jesse Jefferson | | 325 | 305 | 20 |
| 1976-07-06 | vs CHA | 75 | W 4-0 | 38-37 | 2 | 31,423 | Fergie Jenkins | Ken Brett | Fergie Jenkins | Ken Brett | | 329 | 305 | 24 |
| 1976-07-07 | vs CHA | 76 | L 3-6 | 38-38 | 2 | 27,281 | Dick Pole | Bart Johnson | Bart Johnson | Jim Willoughby | Dave Hamilton | 332 | 311 | 21 |
| 1976-07-08 | vs MIN | 77 | W 8-4 | 39-38 | 2 | 25,970 | Rick Jones | Dave Goltz | Rick Jones | Dave Goltz | Reggie Cleveland | 340 | 315 | 25 |
| 1976-07-09 | vs MIN | 78 | L 6-8 | 39-39 | 2 | 29,917 | Rick Wise | Pete Redfern | Bill Campbell | Rick Wise | | 346 | 323 | 23 |
| 1976-07-10 | vs MIN | 79 | L 2-4 | 39-40 | 2 | 28,347 | Luis Tiant | Eddie Bane | Eddie Bane | Luis Tiant | Bill Campbell | 348 | 327 | 21 |
| 1976-07-11 | vs MIN | 80 | W 6-4 | 40-40 | 2 | 26,580 | Fergie Jenkins | Bill Singer | Fergie Jenkins | Bill Singer | Jim Willoughby | 354 | 331 | 23 |
| 1976-07-15 | @ KCA | 81 | L 5-12 | 41-41 | 2 | 0 | Dick Pole | Dennis Leonard | Dennis Leonard | Dick Pole | | 359 | 343 | 16 |
| 1976-07-15 | @ KCA | 82 | W 2-1 | 41-41 | 2 | 24,720 | Rick Jones | Doug Bird | Rick Jones | Doug Bird | Jim Willoughby | 361 | 344 | 17 |
| 1976-07-16 | @ KCA | 83 | L 1-5 | 41-43 | 4 | 0 | Fergie Jenkins | Paul Splittorff | Paul Splittorff | Tom Murphy | | 362 | 349 | 13 |
| 1976-07-16 | @ KCA | 84 | L 1-2 | 41-43 | 4 | 35,600 | Rick Wise | Al Fitzmorris | Al Fitzmorris | Rick Wise | | 363 | 351 | 12 |
| 1976-07-17 | @ KCA | 85 | L 1-2 | 41-44 | 5 | 24,411 | Luis Tiant | Andy Hassler | Mark Littell | Luis Tiant | | 364 | 353 | 11 |
| 1976-07-18 | @ KCA | 86 | L 3-6 | 41-45 | 5 | 29,267 | Reggie Cleveland | Marty Pattin | Marty Pattin | Reggie Cleveland | | 367 | 359 | 8 |
| 1976-07-19 | @ TEX | 87 | L 3-4 | 41-46 | 5 | 11,166 | Dick Pole | Tommy Boggs | Mike Bacsik | Jim Willoughby | | 370 | 363 | 7 |
| 1976-07-20 | @ TEX | 88 | W 4-2 | 42-46 | 5 | 13,495 | Rick Jones | Nelson Briles | Rick Jones | Nelson Briles | Jim Willoughby | 374 | 365 | 9 |
| 1976-07-21 | @ MIN | 89 | L 1-5 | 42-47 | 4 | 7,698 | Rick Wise | Dave Goltz | Dave Goltz | Rick Wise | | 375 | 370 | 5 |
| 1976-07-22 | @ MIN | 90 | L 1-5 | 42-48 | 5 | 7,972 | Luis Tiant | Pete Redfern | Pete Redfern | Luis Tiant | | 376 | 375 | 1 |
| 1976-07-23 | @ NYA | 91 | L 1-9 | 42-49 | 5 | 43,252 | Bill Lee | Doyle Alexander | Doyle Alexander | Bill Lee | | 377 | 384 | -7 |
| 1976-07-24 | @ NYA | 92 | L 1-4 | 42-50 | 5 | 46,925 | Rick Jones | Ed Figueroa | Ed Figueroa | Rick Jones | | 378 | 388 | -10 |
| 1976-07-25 | @ NYA | 93 | L 5-6 | 42-51 | 5 | 49,723 | Rick Wise | Ken Holtzman | Dick Tidrow | Tom House | | 383 | 394 | -11 |
| 1976-07-26 | vs CLE | 94 | L 4-9 | 42-52 | 5 | 21,897 | Luis Tiant | Stan Thomas | Tom Buskey | Luis Tiant | | 387 | 403 | -16 |
| 1976-07-27 | vs CLE | 95 | W 8-7 | 43-52 | 5 | 20,969 | Fergie Jenkins | Jim Bibby | Fergie Jenkins | Jim Bibby | Tom Murphy | 395 | 410 | -15 |
| 1976-07-28 | vs CLE | 96 | L 6-7 | 43-53 | 5 | 22,246 | Rick Jones | Jackie Brown | Jim Kern | Jim Willoughby | Dave LaRoche | 401 | 417 | -16 |
| 1976-07-29 | vs CLE | 97 | W 6-4 | 44-53 | 5 | 29,412 | Rick Wise | Pat Dobson | Rick Wise | Pat Dobson | Bill Lee | 407 | 421 | -14 |
| 1976-07-30 | vs NYA | 98 | L 4-6 | 44-54 | 5 | 27,728 | Luis Tiant | Ed Figueroa | Ed Figueroa | Luis Tiant | | 411 | 427 | -16 |
| 1976-07-31 | vs NYA | 99 | W 4-2 | 46-54 | 5 | 28,799 | Fergie Jenkins | Ken Holtzman | Fergie Jenkins | Ken Holtzman | | 415 | 429 | -14 |
| 1976-07-31 | vs NYA | 100 | W 6-4 | 46-54 | 5 | 26,637 | Reggie Cleveland | Catfish Hunter | Reggie Cleveland | Catfish Hunter | Tom Murphy | 421 | 433 | -12 |
| 1976-08-01 | vs NYA | 101 | W 5-4 | 47-54 | 5 | 29,127 | Rick Jones | Dock Ellis | Bill Lee | Dick Tidrow | | 426 | 437 | -11 |
| 1976-08-02 | @ CLE | 102 | W 3-1 | 48-54 | 5 | 12,182 | Rick Wise | Pat Dobson | Rick Wise | Pat Dobson | | 429 | 438 | -9 |
| 1976-08-03 | @ CLE | 103 | L 0-1 | 48-55 | 5 | 10,187 | Luis Tiant | Dennis Eckersley | Dennis Eckersley | Tom Murphy | | 429 | 439 | -10 |
| 1976-08-04 | @ DET | 104 | W 4-1 | 49-55 | 4 | 14,924 | Fergie Jenkins | Vern Ruhle | Fergie Jenkins | Vern Ruhle | | 433 | 440 | -7 |
| 1976-08-05 | @ DET | 105 | W 5-4 | 50-55 | 4 | 14,419 | Rick Jones | Dave Lemanczyk | Reggie Cleveland | Dave Lemanczyk | Bill Lee | 438 | 444 | -6 |
| 1976-08-06 | vs MIL | 106 | W 2-1 | 51-55 | 4 | 25,544 | Rick Wise | Jim Colborn | Tom Murphy | Jim Colborn | | 440 | 445 | -5 |
| 1976-08-07 | vs MIL | 107 | W 3-0 | 52-55 | 4 | 24,514 | Luis Tiant | Eduardo Rodriguez | Luis Tiant | Eduardo Rodriguez | Jim Willoughby | 443 | 445 | -2 |
| 1976-08-10 | @ CAL | 108 | L 4-5 | 52-56 | 4 | 10,836 | Fergie Jenkins | Gary Ross | Gary Ross | Fergie Jenkins | | 447 | 450 | -3 |
| 1976-08-11 | @ CAL | 109 | L 0-6 | 52-57 | 5 | 13,741 | Rick Wise | Frank Tanana | Frank Tanana | Rick Wise | | 447 | 456 | -9 |
| 1976-08-12 | @ CAL | 110 | W 2-1 | 53-57 | 5 | 15,242 | Luis Tiant | Nolan Ryan | Luis Tiant | Nolan Ryan | | 449 | 457 | -8 |
| 1976-08-13 | @ OAK | 111 | L 0-2 | 53-58 | 5 | 6,156 | Reggie Cleveland | Mike Norris | Mike Norris | Reggie Cleveland | Rollie Fingers | 449 | 459 | -10 |
| 1976-08-14 | @ OAK | 112 | L 3-7 | 53-59 | 5 | 7,066 | Fergie Jenkins | Vida Blue | Vida Blue | Fergie Jenkins | | 452 | 466 | -14 |
| 1976-08-15 | @ OAK | 113 | L 7-8 | 53-60 | 5 | 9,087 | Rick Wise | Mike Torrez | Stan Bahnsen | Jim Willoughby | | 459 | 474 | -15 |
| 1976-08-16 | @ CHA | 114 | W 12-5 | 54-60 | 5 | 7,733 | Luis Tiant | Bart Johnson | Luis Tiant | Bart Johnson | Bill Lee | 471 | 479 | -8 |
| 1976-08-17 | @ CHA | 115 | L 1-2 | 55-61 | 5 | 0 | Reggie Cleveland | Ken Kravec | Clay Carroll | Tom Murphy | | 472 | 481 | -9 |
| 1976-08-17 | @ CHA | 116 | W 11-7 | 55-61 | 5 | 18,416 | Rick Kreuger | Blue Moon Odom | Dick Pole | Blue Moon Odom | | 483 | 488 | -5 |
| 1976-08-18 | @ CHA | 117 | L 2-4 | 55-62 | 5 | 10,136 | Fergie Jenkins | Rich Gossage | Rich Gossage | Fergie Jenkins | | 485 | 492 | -7 |
| 1976-08-19 | @ CHA | 118 | L 2-4 | 55-63 | 5 | 10,636 | Rick Wise | Ken Brett | Ken Brett | Rick Wise | | 487 | 496 | -9 |
| 1976-08-20 | vs OAK | 119 | W 2-1 | 56-63 | 5 | 30,132 | Luis Tiant | Mike Torrez | Luis Tiant | Rollie Fingers | | 489 | 497 | -8 |
| 1976-08-21 | vs OAK | 120 | W 5-2 | 57-63 | 5 | 27,299 | Reggie Cleveland | Dick Bosman | Reggie Cleveland | Dick Bosman | Tom Murphy | 494 | 499 | -5 |
| 1976-08-22 | vs OAK | 121 | L 6-7 | 57-64 | 5 | 27,526 | Fergie Jenkins | Mike Norris | Rollie Fingers | Jim Willoughby | | 500 | 506 | -6 |
| 1976-08-23 | vs CAL | 122 | W 7-3 | 58-64 | 5 | 24,125 | Bill Lee | Nolan Ryan | Bill Lee | Nolan Ryan | Tom Murphy | 507 | 509 | -2 |
| 1976-08-24 | vs CAL | 123 | L 5-6 | 58-65 | 5 | 24,104 | Rick Wise | Paul Hartzell | Paul Hartzell | Jim Willoughby | | 512 | 515 | -3 |
| 1976-08-25 | vs CAL | 124 | W 8-2 | 59-65 | 5 | 21,513 | Luis Tiant | Don Kirkwood | Luis Tiant | Don Kirkwood | | 520 | 517 | 3 |
| 1976-08-26 | vs KCA | 125 | L 6-7 | 59-66 | 5 | 24,199 | Reggie Cleveland | Marty Pattin | Tom Bruno | Jim Willoughby | | 526 | 524 | 2 |
| 1976-08-27 | vs KCA | 126 | W 9-4 | 60-66 | 5 | 24,940 | Fergie Jenkins | Doug Bird | Fergie Jenkins | Doug Bird | | 535 | 528 | 7 |
| 1976-08-28 | vs KCA | 127 | L 3-8 | 60-67 | 5 | 27,058 | Bill Lee | Al Fitzmorris | Al Fitzmorris | Bill Lee | Mark Littell | 538 | 536 | 2 |
| 1976-08-29 | vs KCA | 128 | W 15-6 | 61-67 | 4 | 26,747 | Rick Wise | Dennis Leonard | Rick Wise | Dennis Leonard | | 553 | 542 | 11 |
| 1976-08-30 | vs TEX | 129 | W 11-3 | 62-67 | 4 | 17,101 | Luis Tiant | Bert Blyleven | Luis Tiant | Bert Blyleven | | 564 | 545 | 19 |
| 1976-08-31 | vs TEX | 130 | L 3-8 | 62-68 | 4 | 18,145 | Reggie Cleveland | Nelson Briles | Nelson Briles | Reggie Cleveland | | 567 | 553 | 14 |
| 1976-09-01 | vs TEX | 131 | W 3-0 | 63-68 | 4 | 19,330 | Fergie Jenkins | Gaylord Perry | Tom Murphy | Gaylord Perry | | 570 | 553 | 17 |
| 1976-09-03 | @ CLE | 132 | W 5-3 | 64-68 | 4 | 7,280 | Luis Tiant | Jackie Brown | Luis Tiant | Jackie Brown | | 575 | 556 | 19 |
| 1976-09-04 | @ CLE | 133 | W 7-6 | 65-69 | 4 | 0 | Rick Wise | Dennis Eckersley | Rick Wise | Dennis Eckersley | Tom House | 582 | 562 | 20 |
| 1976-09-04 | @ CLE | 134 | L 0-4 | 65-69 | 4 | 25,793 | Bill Lee | Pat Dobson | Pat Dobson | Bill Lee | Jim Kern | 582 | 566 | 16 |
| 1976-09-05 | @ CLE | 135 | L 3-6 | 65-70 | 4 | 10,124 | Reggie Cleveland | Rick Waits | Rick Waits | Reggie Cleveland | Dave LaRoche | 585 | 572 | 13 |
| 1976-09-06 | @ NYA | 136 | L 5-6 | 65-71 | 4 | 25,118 | Rick Jones | Doyle Alexander | Doyle Alexander | Rick Jones | Dick Tidrow | 590 | 578 | 12 |
| 1976-09-07 | @ NYA | 137 | L 2-4 | 65-72 | 4 | 23,160 | Luis Tiant | Dock Ellis | Dock Ellis | Luis Tiant | Dick Tidrow | 592 | 582 | 10 |
| 1976-09-08 | vs DET | 138 | W 4-3 | 66-72 | 4 | 13,966 | Bill Lee | Dave Lemanczyk | Bill Lee | Dave Lemanczyk | Jim Willoughby | 596 | 585 | 11 |
| 1976-09-09 | vs DET | 139 | W 5-0 | 67-72 | 4 | 13,643 | Rick Wise | Vern Ruhle | Rick Wise | Vern Ruhle | | 601 | 585 | 16 |
| 1976-09-10 | vs DET | 140 | L 0-1 | 67-73 | 4 | 19,192 | Reggie Cleveland | Ray Bare | Ray Bare | Reggie Cleveland | | 601 | 586 | 15 |
| 1976-09-11 | vs CLE | 141 | L 5-6 | 67-74 | 4 | 21,421 | Rick Jones | Jim Bibby | Jim Bibby | Rick Jones | Dave LaRoche | 606 | 592 | 14 |
| 1976-09-12 | vs CLE | 142 | W 11-3 | 68-74 | 4 | 24,819 | Luis Tiant | Stan Thomas | Luis Tiant | Stan Thomas | | 617 | 595 | 22 |
| 1976-09-13 | vs CLE | 143 | L 3-8 | 68-75 | 4 | 12,101 | Bill Lee | Dennis Eckersley | Dennis Eckersley | Bill Lee | Dave LaRoche | 620 | 603 | 17 |
| 1976-09-14 | @ MIL | 144 | L 2-3 | 68-76 | 4 | 4,298 | Rick Wise | Jim Slaton | Danny Frisella | Jim Willoughby | | 622 | 606 | 16 |
| 1976-09-15 | @ MIL | 145 | W 2-1 | 69-76 | 4 | 3,656 | Reggie Cleveland | Gary Beare | Reggie Cleveland | Gary Beare | Tom Murphy | 624 | 607 | 17 |
| 1976-09-16 | @ MIL | 146 | W 4-3 | 70-76 | 4 | 3,545 | Rick Kreuger | Jim Colborn | Rick Kreuger | Bill Castro | Tom Murphy | 628 | 610 | 18 |
| 1976-09-17 | @ DET | 147 | W 8-3 | 71-76 | 4 | 20,371 | Luis Tiant | Mark Fidrych | Luis Tiant | Mark Fidrych | | 636 | 613 | 23 |
| 1976-09-18 | @ DET | 148 | W 5-4 | 72-76 | 4 | 12,156 | Bill Lee | Vern Ruhle | Bill Lee | Vern Ruhle | Tom Murphy | 641 | 617 | 24 |
| 1976-09-19 | @ DET | 149 | W 6-1 | 73-76 | 4 | 8,949 | Rick Wise | Dave Roberts | Rick Wise | Dave Roberts | | 647 | 618 | 29 |
| 1976-09-20 | @ DET | 150 | W 12-6 | 74-76 | 4 | 5,328 | Reggie Cleveland | Ed Glynn | Rick Jones | Ed Glynn | | 659 | 624 | 35 |
| 1976-09-21 | vs MIL | 151 | W 7-1 | 75-77 | 4 | 0 | Luis Tiant | Moose Haas | Luis Tiant | Moose Haas | | 666 | 625 | 41 |
| 1976-09-21 | vs MIL | 152 | L 1-3 | 75-77 | 4 | 17,840 | Rick Kreuger | Jim Colborn | Jim Colborn | Rick Kreuger | | 667 | 628 | 39 |
| 1976-09-22 | vs MIL | 153 | W 6-3 | 76-77 | 4 | 11,796 | Dick Pole | Jerry Augustine | Dick Pole | Jerry Augustine | Jim Willoughby | 673 | 631 | 42 |
| 1976-09-23 | vs MIL | 154 | W 10-3 | 77-77 | 4 | 6,154 | Bill Lee | Bill Travers | Bill Lee | Bill Travers | | 683 | 634 | 49 |
| 1976-09-24 | @ BAL | 155 | L 0-3 | 77-78 | 4 | 7,285 | Rick Wise | Wayne Garland | Wayne Garland | Rick Wise | | 683 | 637 | 46 |
| 1976-09-25 | @ BAL | 156 | W 1-0 | 78-78 | 4 | 10,562 | Luis Tiant | Ross Grimsley | Luis Tiant | Ross Grimsley | | 684 | 637 | 47 |
| 1976-09-26 | @ BAL | 157 | W 8-3 | 79-78 | 4 | 8,272 | Reggie Cleveland | Dennis Martinez | Reggie Cleveland | Dennis Martinez | | 692 | 640 | 52 |
| 1976-09-28 | vs NYA | 158 | W 7-5 | 80-78 | 4 | 21,200 | Rick Kreuger | Ed Figueroa | Rick Kreuger | Ed Figueroa | Tom Murphy | 699 | 645 | 54 |
| 1976-09-29 | vs NYA | 159 | L 6-9 | 80-79 | 4 | 23,980 | Luis Tiant | Catfish Hunter | Catfish Hunter | Luis Tiant | | 705 | 654 | 51 |
| 1976-10-01 | vs BAL | 160 | W 7-4 | 81-79 | 4 | 15,749 | Rick Wise | Dave Pagan | Rick Wise | Fred Holdsworth | Jim Willoughby | 712 | 658 | 54 |
| 1976-10-02 | vs BAL | 161 | W 1-0 | 82-79 | 4 | 12,753 | Reggie Cleveland | Dennis Martinez | Reggie Cleveland | Dennis Martinez | Jim Willoughby | 713 | 658 | 55 |
| 1976-10-03 | vs BAL | 162 | W 3-2 | 83-79 | 3 | 19,845 | Luis Tiant | Scott McGregor | Jim Willoughby | Mike Flanagan | | 716 | 660 | 56 |