| 1976-04-09 | vs BOS | 1 | W 1-0 | 1-0 | 1 | 46,425 | Jim Palmer | Fergie Jenkins | Jim Palmer | Fergie Jenkins | Dyar Miller | 1 | 0 | 1 |
| 1976-04-10 | vs BOS | 2 | W 5-1 | 2-0 | 1 | 8,899 | Ken Holtzman | Rick Wise | Ken Holtzman | Tom House | | 6 | 1 | 5 |
| 1976-04-11 | vs BOS | 3 | L 2-6 | 2-1 | 2 | 13,418 | Mike Cuellar | Luis Tiant | Luis Tiant | Mike Cuellar | | 8 | 7 | 1 |
| 1976-04-12 | vs NYA | 4 | L 0-3 | 2-2 | 3 | 7,143 | Ross Grimsley | Catfish Hunter | Catfish Hunter | Ross Grimsley | | 8 | 10 | -2 |
| 1976-04-13 | vs NYA | 5 | L 1-7 | 2-3 | 5 | 8,280 | Jim Palmer | Dock Ellis | Dock Ellis | Jim Palmer | | 9 | 17 | -8 |
| 1976-04-17 | @ OAK | 6 | W 6-1 | 3-3 | 3 | 28,017 | Jim Palmer | Mike Torrez | Jim Palmer | Mike Torrez | | 15 | 18 | -3 |
| 1976-04-18 | @ OAK | 7 | L 1-2 | 3-4 | 4 | 7,680 | Ken Holtzman | Vida Blue | Rollie Fingers | Dyar Miller | | 16 | 20 | -4 |
| 1976-04-19 | @ CAL | 8 | L 4-9 | 3-5 | 5 | 14,201 | Mike Cuellar | Frank Tanana | Frank Tanana | Mike Cuellar | | 20 | 29 | -9 |
| 1976-04-20 | @ CAL | 9 | L 0-5 | 3-6 | 6 | 13,805 | Doyle Alexander | Nolan Ryan | Nolan Ryan | Doyle Alexander | | 20 | 34 | -14 |
| 1976-04-21 | @ CAL | 10 | W 5-1 | 4-6 | 6 | 9,875 | Jim Palmer | Don Kirkwood | Jim Palmer | Don Kirkwood | Dyar Miller | 25 | 35 | -10 |
| 1976-04-24 | @ MIN | 11 | L 1-2 | 4-7 | 6 | 4,222 | Ken Holtzman | Bert Blyleven | Bill Campbell | Grant Jackson | | 26 | 37 | -11 |
| 1976-04-25 | @ MIN | 12 | L 2-7 | 4-8 | 6 | 5,657 | Jim Palmer | Joe Decker | Tom Burgmeier | Jim Palmer | | 28 | 44 | -16 |
| 1976-04-27 | vs CAL | 13 | W 3-2 | 5-8 | 6 | 3,661 | Mike Cuellar | Nolan Ryan | Grant Jackson | Dick Drago | | 31 | 46 | -15 |
| 1976-04-28 | vs CAL | 14 | W 4-2 | 6-8 | 6 | 3,678 | Ken Holtzman | Gary Ross | Ken Holtzman | Gary Ross | | 35 | 48 | -13 |
| 1976-04-30 | vs OAK | 15 | L 1-11 | 6-9 | 6 | 12,501 | Jim Palmer | Mike Torrez | Mike Torrez | Jim Palmer | | 36 | 59 | -23 |
| 1976-05-02 | vs OAK | 16 | L 2-6 | 7-10 | 5 | 0 | Ross Grimsley | Vida Blue | Vida Blue | Ross Grimsley | | 38 | 65 | -27 |
| 1976-05-02 | vs OAK | 17 | W 4-3 | 7-10 | 5 | 24,819 | Mike Cuellar | Mike Norris | Wayne Garland | Glenn Abbott | | 42 | 68 | -26 |
| 1976-05-04 | vs CHA | 18 | L 1-3 | 7-11 | 5 | 6,160 | Ken Holtzman | Wilbur Wood | Wilbur Wood | Ken Holtzman | | 43 | 71 | -28 |
| 1976-05-05 | vs CHA | 19 | W 2-0 | 8-11 | 5 | 6,570 | Jim Palmer | Rich Gossage | Jim Palmer | Rich Gossage | | 45 | 71 | -26 |
| 1976-05-07 | vs KCA | 20 | W 4-3 | 9-11 | 5 | 7,310 | Mike Cuellar | Steve Busby | Wayne Garland | Marty Pattin | | 49 | 74 | -25 |
| 1976-05-08 | vs KCA | 21 | L 3-6 | 9-12 | 5 | 51,195 | Ken Holtzman | Dennis Leonard | Dennis Leonard | Ken Holtzman | Doug Bird | 52 | 80 | -28 |
| 1976-05-09 | vs KCA | 22 | L 4-7 | 9-13 | 5 | 7,590 | Jim Palmer | Al Fitzmorris | Mark Littell | Jim Palmer | | 56 | 87 | -31 |
| 1976-05-11 | @ MIL | 23 | W 5-2 | 10-13 | 5 | 6,236 | Mike Cuellar | Jim Colborn | Mike Cuellar | Jim Colborn | Wayne Garland | 61 | 89 | -28 |
| 1976-05-12 | @ MIL | 24 | W 8-6 | 11-13 | 4 | 5,657 | Ken Holtzman | Jim Slaton | Doyle Alexander | Jerry Augustine | | 69 | 95 | -26 |
| 1976-05-13 | @ MIL | 25 | W 5-3 | 12-13 | 4 | 7,173 | Jim Palmer | Bill Travers | Jim Palmer | Bill Travers | | 74 | 98 | -24 |
| 1976-05-14 | @ NYA | 26 | W 6-2 | 13-13 | 3 | 27,431 | Ross Grimsley | Catfish Hunter | Ross Grimsley | Catfish Hunter | Grant Jackson | 80 | 100 | -20 |
| 1976-05-15 | @ NYA | 27 | L 3-7 | 13-14 | 3 | 22,242 | Mike Cuellar | Ed Figueroa | Ed Figueroa | Mike Cuellar | Sparky Lyle | 83 | 107 | -24 |
| 1976-05-16 | @ NYA | 28 | W 7-0 | 14-14 | 3 | 25,465 | Ken Holtzman | Dock Ellis | Ken Holtzman | Dock Ellis | | 90 | 107 | -17 |
| 1976-05-17 | vs MIL | 29 | W 4-3 | 15-14 | 2 | 10,755 | Jim Palmer | Bill Travers | Dyar Miller | Eduardo Rodriguez | | 94 | 110 | -16 |
| 1976-05-19 | vs MIL | 30 | W 5-3 | 16-14 | 2 | 4,839 | Mike Cuellar | Jim Colborn | Mike Cuellar | Jim Colborn | Grant Jackson | 99 | 113 | -14 |
| 1976-05-21 | vs DET | 31 | W 8-5 | 17-14 | 2 | 12,184 | Jim Palmer | Ray Bare | Doyle Alexander | Ray Bare | | 107 | 118 | -11 |
| 1976-05-22 | vs DET | 32 | W 8-4 | 18-14 | 2 | 16,337 | Ross Grimsley | Joe Coleman | Wayne Garland | Jim Crawford | | 115 | 122 | -7 |
| 1976-05-23 | vs DET | 33 | L 6-10 | 18-15 | 2 | 13,628 | Ken Holtzman | Vern Ruhle | John Hiller | Dyar Miller | | 121 | 132 | -11 |
| 1976-05-24 | vs CLE | 34 | L 0-4 | 18-16 | 2 | 7,835 | Mike Cuellar | Dennis Eckersley | Dennis Eckersley | Mike Cuellar | | 121 | 136 | -15 |
| 1976-05-25 | vs CLE | 35 | L 1-3 | 18-17 | 2 | 7,543 | Jim Palmer | Pat Dobson | Pat Dobson | Jim Palmer | | 122 | 139 | -17 |
| 1976-05-26 | @ DET | 36 | W 6-0 | 19-18 | 2 | 0 | Doyle Alexander | Bill Laxton | Doyle Alexander | Bill Laxton | | 128 | 139 | -11 |
| 1976-05-26 | @ DET | 37 | L 2-6 | 19-18 | 2 | 24,856 | Ross Grimsley | Ray Bare | Ray Bare | Ross Grimsley | John Hiller | 130 | 145 | -15 |
| 1976-05-27 | @ DET | 38 | W 4-3 | 20-18 | 2 | 9,397 | Ken Holtzman | Joe Coleman | Ken Holtzman | Joe Coleman | Dyar Miller | 134 | 148 | -14 |
| 1976-05-28 | @ BOS | 39 | W 4-1 | 21-18 | 2 | 33,250 | Wayne Garland | Reggie Cleveland | Wayne Garland | Reggie Cleveland | Grant Jackson | 138 | 149 | -11 |
| 1976-05-29 | @ BOS | 40 | W 7-2 | 22-18 | 2 | 33,238 | Jim Palmer | Luis Tiant | Jim Palmer | Luis Tiant | | 145 | 151 | -6 |
| 1976-05-30 | @ BOS | 41 | L 1-3 | 22-19 | 2 | 28,300 | Doyle Alexander | Rick Wise | Rick Wise | Doyle Alexander | | 146 | 154 | -8 |
| 1976-05-31 | @ CLE | 42 | L 1-4 | 22-21 | 2 | 0 | Ken Holtzman | Jim Kern | Jim Kern | Ken Holtzman | Stan Thomas | 147 | 158 | -11 |
| 1976-05-31 | @ CLE | 43 | L 3-4 | 22-21 | 2 | 17,931 | Mike Cuellar | Pat Dobson | Pat Dobson | Mike Cuellar | Dave LaRoche | 150 | 162 | -12 |
| 1976-06-02 | @ CLE | 44 | W 2-0 | 23-21 | 2 | 7,447 | Jim Palmer | Jackie Brown | Wayne Garland | Tom Buskey | | 152 | 162 | -10 |
| 1976-06-04 | vs MIN | 45 | L 6-8 | 23-22 | 2 | 35,111 | Doyle Alexander | Dave Goltz | Bill Campbell | Mike Flanagan | | 158 | 170 | -12 |
| 1976-06-05 | vs MIN | 46 | W 5-1 | 24-22 | 2 | 7,673 | Ken Holtzman | Joe Decker | Ken Holtzman | Joe Decker | | 163 | 171 | -8 |
| 1976-06-06 | vs MIN | 47 | L 2-3 | 24-24 | 2 | 0 | Jim Palmer | Bill Singer | Bill Singer | Jim Palmer | | 165 | 174 | -9 |
| 1976-06-06 | vs MIN | 48 | L 6-11 | 24-24 | 2 | 19,046 | Mike Cuellar | Jim Hughes | Jim Hughes | Mike Cuellar | Bill Campbell | 171 | 185 | -14 |
| 1976-06-07 | vs TEX | 49 | L 4-6 | 24-25 | 2 | 11,626 | Ross Grimsley | Jim Umbarger | Jim Umbarger | Ross Grimsley | Steve Foucault | 175 | 191 | -16 |
| 1976-06-08 | vs TEX | 50 | L 3-6 | 24-26 | 2 | 10,006 | Doyle Alexander | Fritz Peterson | Fritz Peterson | Doyle Alexander | Steve Foucault | 178 | 197 | -19 |
| 1976-06-09 | vs TEX | 51 | L 1-4 | 24-27 | 3 | 8,379 | Ken Holtzman | Gaylord Perry | Gaylord Perry | Ken Holtzman | | 179 | 201 | -22 |
| 1976-06-10 | @ KCA | 52 | L 0-7 | 24-28 | 3 | 12,210 | Jim Palmer | Paul Splittorff | Paul Splittorff | Jim Palmer | | 179 | 208 | -29 |
| 1976-06-11 | @ KCA | 53 | L 0-4 | 24-29 | 4 | 25,883 | Mike Cuellar | Doug Bird | Doug Bird | Mike Cuellar | Mark Littell | 179 | 212 | -33 |
| 1976-06-12 | @ KCA | 54 | L 6-7 | 24-30 | 5 | 19,693 | Doyle Alexander | Steve Busby | Steve Busby | Doyle Alexander | Marty Pattin | 185 | 219 | -34 |
| 1976-06-13 | @ KCA | 55 | L 4-8 | 24-31 | 5 | 23,751 | Mike Flanagan | Dennis Leonard | Dennis Leonard | Mike Flanagan | | 189 | 227 | -38 |
| 1976-06-15 | @ CHA | 56 | W 4-0 | 25-31 | 4 | 10,794 | Jim Palmer | Rich Gossage | Jim Palmer | Rich Gossage | | 193 | 227 | -34 |
| 1976-06-16 | @ CHA | 57 | W 10-2 | 26-31 | 4 | 13,827 | Mike Cuellar | Francisco Barrios | Mike Cuellar | Francisco Barrios | | 203 | 229 | -26 |
| 1976-06-17 | @ TEX | 58 | W 4-1 | 27-31 | 4 | 15,400 | Wayne Garland | Nelson Briles | Wayne Garland | Nelson Briles | Dave Pagan | 207 | 230 | -23 |
| 1976-06-18 | @ TEX | 59 | W 9-4 | 28-31 | 4 | 32,001 | Rudy May | Jim Umbarger | Rudy May | Jim Umbarger | | 216 | 234 | -18 |
| 1976-06-19 | @ TEX | 60 | W 8-4 | 29-31 | 3 | 23,652 | Jim Palmer | Fritz Peterson | Jim Palmer | Steve Foucault | | 224 | 238 | -14 |
| 1976-06-20 | @ TEX | 61 | W 2-0 | 30-31 | 3 | 20,081 | Mike Cuellar | Gaylord Perry | Mike Cuellar | Gaylord Perry | | 226 | 238 | -12 |
| 1976-06-21 | vs BOS | 62 | W 2-0 | 31-31 | 2 | 18,940 | Wayne Garland | Luis Tiant | Wayne Garland | Luis Tiant | | 228 | 238 | -10 |
| 1976-06-22 | vs BOS | 63 | L 5-6 | 31-32 | 3 | 23,577 | Rudy May | Dick Pole | Reggie Cleveland | Dave Pagan | | 233 | 244 | -11 |
| 1976-06-23 | vs BOS | 64 | W 3-2 | 32-32 | 3 | 23,357 | Jim Palmer | Rick Jones | Jim Palmer | Jim Willoughby | | 236 | 246 | -10 |
| 1976-06-25 | vs CLE | 65 | L 5-6 | 32-33 | 3 | 16,069 | Mike Cuellar | Jackie Brown | Stan Thomas | Dave Pagan | | 241 | 252 | -11 |
| 1976-06-26 | vs CLE | 66 | W 2-1 | 33-33 | 3 | 21,431 | Wayne Garland | Dennis Eckersley | Wayne Garland | Dennis Eckersley | | 243 | 253 | -10 |
| 1976-06-27 | vs CLE | 67 | L 3-6 | 34-34 | 3 | 0 | Rudy May | Pat Dobson | Pat Dobson | Rudy May | Jim Kern | 246 | 259 | -13 |
| 1976-06-27 | vs CLE | 68 | W 6-2 | 34-34 | 3 | 27,313 | Ross Grimsley | Rick Waits | Ross Grimsley | Rick Waits | Tippy Martinez | 252 | 261 | -9 |
| 1976-06-28 | @ BOS | 69 | L 8-12 | 34-35 | 3 | 27,648 | Jim Palmer | Rick Jones | Fergie Jenkins | Mike Flanagan | | 260 | 273 | -13 |
| 1976-06-29 | @ BOS | 70 | L 0-2 | 34-36 | 4 | 30,054 | Mike Cuellar | Rick Wise | Rick Wise | Mike Cuellar | | 260 | 275 | -15 |
| 1976-06-30 | @ BOS | 71 | L 4-6 | 34-37 | 5 | 29,348 | Wayne Garland | Luis Tiant | Jim Willoughby | Wayne Garland | | 264 | 281 | -17 |
| 1976-07-01 | vs DET | 72 | L 0-2 | 34-38 | 5 | 8,746 | Rudy May | Dave Roberts | Dave Roberts | Rudy May | | 264 | 283 | -19 |
| 1976-07-02 | vs DET | 73 | W 2-1 | 35-38 | 5 | 32,338 | Jim Palmer | Vern Ruhle | Jim Palmer | Vern Ruhle | | 266 | 284 | -18 |
| 1976-07-03 | @ DET | 74 | L 0-4 | 35-39 | 5 | 51,032 | Mike Cuellar | Mark Fidrych | Mark Fidrych | Mike Cuellar | | 266 | 288 | -22 |
| 1976-07-04 | @ DET | 75 | W 7-4 | 36-39 | 5 | 14,454 | Wayne Garland | Frank MacCormack | Wayne Garland | John Hiller | | 273 | 292 | -19 |
| 1976-07-05 | @ OAK | 76 | L 1-4 | 36-40 | 5 | 40,502 | Rudy May | Mike Torrez | Mike Torrez | Rudy May | Rollie Fingers | 274 | 296 | -22 |
| 1976-07-06 | @ OAK | 77 | L 0-2 | 36-41 | 5 | 6,024 | Jim Palmer | Vida Blue | Vida Blue | Jim Palmer | | 274 | 298 | -24 |
| 1976-07-07 | @ OAK | 78 | L 3-5 | 36-42 | 5 | 4,681 | Mike Cuellar | Paul Mitchell | Paul Mitchell | Mike Cuellar | Rollie Fingers | 277 | 303 | -26 |
| 1976-07-08 | @ OAK | 79 | W 9-6 | 37-42 | 5 | 3,798 | Wayne Garland | Mike Norris | Wayne Garland | Paul Lindblad | Dyar Miller | 286 | 309 | -23 |
| 1976-07-09 | @ CAL | 80 | W 4-3 | 38-42 | 5 | 14,409 | Rudy May | Frank Tanana | Rudy May | Frank Tanana | Tippy Martinez | 290 | 312 | -22 |
| 1976-07-10 | @ CAL | 81 | W 5-2 | 39-42 | 4 | 17,242 | Jim Palmer | Gary Ross | Jim Palmer | Gary Ross | | 295 | 314 | -19 |
| 1976-07-11 | @ CAL | 82 | W 3-1 | 40-42 | 3 | 12,450 | Dave Pagan | Nolan Ryan | Dave Pagan | Nolan Ryan | Tippy Martinez | 298 | 315 | -17 |
| 1976-07-15 | vs CAL | 83 | W 4-0 | 41-42 | 3 | 9,182 | Jim Palmer | Gary Ross | Jim Palmer | Gary Ross | | 302 | 315 | -13 |
| 1976-07-16 | vs CAL | 84 | W 5-4 | 42-42 | 2 | 11,251 | Wayne Garland | Nolan Ryan | Wayne Garland | Nolan Ryan | Dyar Miller | 307 | 319 | -12 |
| 1976-07-17 | vs CAL | 85 | L 3-7 | 42-43 | 2 | 19,328 | Rudy May | Frank Tanana | Frank Tanana | Rudy May | | 310 | 326 | -16 |
| 1976-07-18 | vs CAL | 86 | L 6-8 | 42-44 | 3 | 13,038 | Dave Pagan | Sid Monge | Dick Drago | Mike Cuellar | | 316 | 334 | -18 |
| 1976-07-19 | @ KCA | 87 | W 4-3 | 43-44 | 2 | 39,355 | Jim Palmer | Dennis Leonard | Jim Palmer | Dennis Leonard | Tippy Martinez | 320 | 337 | -17 |
| 1976-07-20 | @ KCA | 88 | W 10-3 | 44-44 | 2 | 16,145 | Wayne Garland | Doug Bird | Wayne Garland | Doug Bird | | 330 | 340 | -10 |
| 1976-07-21 | @ TEX | 89 | W 6-4 | 45-44 | 2 | 10,273 | Dave Pagan | Bert Blyleven | Tippy Martinez | Joe Hoerner | Fred Holdsworth | 336 | 344 | -8 |
| 1976-07-22 | @ TEX | 90 | W 4-3 | 46-44 | 2 | 10,336 | Ross Grimsley | Gaylord Perry | Fred Holdsworth | Gaylord Perry | | 340 | 347 | -7 |
| 1976-07-23 | vs MIL | 91 | L 3-4 | 46-45 | 3 | 12,451 | Jim Palmer | Jim Slaton | Jim Slaton | Tippy Martinez | Danny Frisella | 343 | 351 | -8 |
| 1976-07-24 | vs MIL | 92 | L 1-4 | 46-47 | 3 | 0 | Mike Cuellar | Eduardo Rodriguez | Eduardo Rodriguez | Mike Cuellar | Bill Castro | 344 | 355 | -11 |
| 1976-07-24 | vs MIL | 93 | L 0-5 | 46-47 | 3 | 17,934 | Wayne Garland | Jerry Augustine | Jerry Augustine | Wayne Garland | | 344 | 360 | -16 |
| 1976-07-25 | vs MIL | 94 | L 1-3 | 46-48 | 2 | 9,414 | Dave Pagan | Bill Travers | Bill Travers | Dave Pagan | | 345 | 363 | -18 |
| 1976-07-26 | vs NYA | 95 | W 3-1 | 47-48 | 2 | 24,303 | Ross Grimsley | Catfish Hunter | Ross Grimsley | Catfish Hunter | | 348 | 364 | -16 |
| 1976-07-27 | vs NYA | 96 | W 4-1 | 48-48 | 2 | 21,153 | Jim Palmer | Dock Ellis | Jim Palmer | Dock Ellis | | 352 | 365 | -13 |
| 1976-07-28 | vs NYA | 97 | W 4-3 | 49-48 | 2 | 23,701 | Wayne Garland | Doyle Alexander | Tippy Martinez | Doyle Alexander | | 356 | 368 | -12 |
| 1976-07-29 | @ DET | 98 | W 1-0 | 50-48 | 2 | 44,068 | Rudy May | Mark Fidrych | Rudy May | Mark Fidrych | | 357 | 368 | -11 |
| 1976-07-30 | @ DET | 99 | W 7-3 | 51-48 | 2 | 22,553 | Ross Grimsley | Vern Ruhle | Ross Grimsley | Vern Ruhle | | 364 | 371 | -7 |
| 1976-07-31 | vs DET | 100 | L 4-5 | 51-49 | 2 | 31,425 | Jim Palmer | Dave Lemanczyk | Dave Lemanczyk | Jim Palmer | John Hiller | 368 | 376 | -8 |
| 1976-08-01 | vs DET | 101 | W 4-3 | 52-49 | 2 | 9,953 | Wayne Garland | Ray Bare | Fred Holdsworth | John Hiller | | 372 | 379 | -7 |
| 1976-08-02 | @ MIL | 102 | L 1-7 | 52-50 | 2 | 8,901 | Rudy May | Jim Colborn | Jim Colborn | Rudy May | | 373 | 386 | -13 |
| 1976-08-03 | @ MIL | 103 | L 2-4 | 52-51 | 2 | 9,282 | Ross Grimsley | Eduardo Rodriguez | Eduardo Rodriguez | Ross Grimsley | | 375 | 390 | -15 |
| 1976-08-04 | @ CLE | 104 | L 0-3 | 52-52 | 3 | 8,316 | Jim Palmer | Rick Waits | Rick Waits | Jim Palmer | | 375 | 393 | -18 |
| 1976-08-05 | @ CLE | 105 | W 6-2 | 53-52 | 2 | 7,521 | Wayne Garland | Jim Bibby | Wayne Garland | Jim Bibby | | 381 | 395 | -14 |
| 1976-08-07 | @ NYA | 106 | W 7-4 | 54-52 | 2 | 47,798 | Rudy May | Doyle Alexander | Rudy May | Doyle Alexander | | 388 | 399 | -11 |
| 1976-08-08 | @ NYA | 107 | W 8-5 | 55-52 | 2 | 34,485 | Ross Grimsley | Catfish Hunter | Ross Grimsley | Catfish Hunter | Mike Cuellar | 396 | 404 | -8 |
| 1976-08-10 | vs MIN | 108 | W 2-0 | 56-52 | 2 | 11,796 | Jim Palmer | Dave Goltz | Jim Palmer | Dave Goltz | | 398 | 404 | -6 |
| 1976-08-11 | vs MIN | 109 | L 0-2 | 56-53 | 2 | 12,228 | Wayne Garland | Bill Singer | Bill Singer | Wayne Garland | | 398 | 406 | -8 |
| 1976-08-13 | vs CHA | 110 | L 2-5 | 56-54 | 2 | 10,906 | Rudy May | Rich Gossage | Rich Gossage | Rudy May | Dave Hamilton | 400 | 411 | -11 |
| 1976-08-14 | vs CHA | 111 | W 8-6 | 58-54 | 2 | 0 | Jim Palmer | Terry Forster | Jim Palmer | Terry Forster | Fred Holdsworth | 408 | 417 | -9 |
| 1976-08-14 | vs CHA | 112 | W 6-5 | 58-54 | 2 | 16,514 | Mike Flanagan | Ken Brett | Dyar Miller | Ken Brett | Tippy Martinez | 414 | 422 | -8 |
| 1976-08-15 | vs CHA | 113 | W 3-0 | 59-54 | 2 | 8,486 | Wayne Garland | Francisco Barrios | Wayne Garland | Francisco Barrios | | 417 | 422 | -5 |
| 1976-08-16 | @ MIN | 114 | W 8-4 | 60-54 | 2 | 5,817 | Ross Grimsley | Steve Luebber | Ross Grimsley | Steve Luebber | | 425 | 426 | -1 |
| 1976-08-17 | @ MIN | 115 | W 10-3 | 61-54 | 2 | 7,850 | Rudy May | Tom Johnson | Rudy May | Tom Johnson | | 435 | 429 | 6 |
| 1976-08-18 | @ MIN | 116 | L 1-5 | 61-55 | 2 | 7,482 | Jim Palmer | Dave Goltz | Dave Goltz | Jim Palmer | Bill Campbell | 436 | 434 | 2 |
| 1976-08-19 | @ MIN | 117 | L 4-5 | 61-56 | 2 | 7,415 | Mike Flanagan | Bill Singer | Bill Singer | Dave Pagan | Bill Campbell | 440 | 439 | 1 |
| 1976-08-20 | @ CHA | 118 | W 6-4 | 62-56 | 2 | 16,257 | Wayne Garland | Francisco Barrios | Wayne Garland | Francisco Barrios | | 446 | 443 | 3 |
| 1976-08-21 | @ CHA | 119 | L 10-11 | 62-57 | 2 | 32,607 | Rudy May | Bart Johnson | Dave Hamilton | Mike Cuellar | | 456 | 454 | 2 |
| 1976-08-22 | @ CHA | 120 | W 6-2 | 63-58 | 2 | 0 | Jim Palmer | Ken Kravec | Jim Palmer | Ken Kravec | | 462 | 456 | 6 |
| 1976-08-22 | @ CHA | 121 | L 3-7 | 63-58 | 2 | 16,991 | Ross Grimsley | Pete Vuckovich | Pete Vuckovich | Ross Grimsley | Francisco Barrios | 465 | 463 | 2 |
| 1976-08-23 | vs OAK | 122 | L 0-3 | 63-59 | 2 | 13,618 | Mike Flanagan | Vida Blue | Vida Blue | Mike Flanagan | | 465 | 466 | -1 |
| 1976-08-24 | vs OAK | 123 | L 4-5 | 63-60 | 2 | 9,482 | Wayne Garland | Mike Torrez | Stan Bahnsen | Wayne Garland | Paul Lindblad | 469 | 471 | -2 |
| 1976-08-25 | vs OAK | 124 | W 9-4 | 64-60 | 2 | 6,942 | Rudy May | Paul Mitchell | Rudy May | Paul Mitchell | | 478 | 475 | 3 |
| 1976-08-27 | vs TEX | 125 | W 3-0 | 65-60 | 2 | 6,418 | Jim Palmer | Gaylord Perry | Jim Palmer | Gaylord Perry | | 481 | 475 | 6 |
| 1976-08-28 | vs TEX | 126 | W 6-4 | 66-60 | 2 | 47,153 | Mike Flanagan | Tommy Boggs | Fred Holdsworth | Steve Hargan | | 487 | 479 | 8 |
| 1976-08-29 | vs TEX | 127 | L 0-11 | 66-61 | 2 | 7,922 | Wayne Garland | Jim Umbarger | Jim Umbarger | Wayne Garland | | 487 | 490 | -3 |
| 1976-08-30 | vs KCA | 128 | W 3-2 | 67-61 | 2 | 6,249 | Rudy May | Andy Hassler | Rudy May | Andy Hassler | | 490 | 492 | -2 |
| 1976-08-31 | vs KCA | 129 | W 4-3 | 68-61 | 2 | 8,661 | Jim Palmer | Marty Pattin | Jim Palmer | Marty Pattin | Dyar Miller | 494 | 495 | -1 |
| 1976-09-01 | vs KCA | 130 | W 7-1 | 69-61 | 2 | 8,007 | Mike Flanagan | Doug Bird | Mike Flanagan | Doug Bird | | 501 | 496 | 5 |
| 1976-09-03 | vs NYA | 131 | L 1-3 | 69-62 | 2 | 17,988 | Wayne Garland | Dock Ellis | Dock Ellis | Wayne Garland | Dick Tidrow | 502 | 499 | 3 |
| 1976-09-04 | vs NYA | 132 | L 2-4 | 70-63 | 2 | 0 | Jim Palmer | Ken Holtzman | Ken Holtzman | Jim Palmer | Dick Tidrow | 504 | 503 | 1 |
| 1976-09-04 | vs NYA | 133 | W 6-2 | 70-63 | 2 | 35,305 | Rudy May | Ed Figueroa | Rudy May | Ed Figueroa | | 510 | 505 | 5 |
| 1976-09-05 | vs NYA | 134 | W 5-3 | 71-63 | 2 | 21,279 | Ross Grimsley | Catfish Hunter | Ross Grimsley | Catfish Hunter | Tippy Martinez | 515 | 508 | 7 |
| 1976-09-06 | @ DET | 135 | L 4-5 | 71-64 | 2 | 8,204 | Mike Flanagan | Dave Roberts | Dave Roberts | Dyar Miller | | 519 | 513 | 6 |
| 1976-09-07 | @ DET | 136 | W 5-3 | 72-64 | 2 | 16,410 | Wayne Garland | Mark Fidrych | Wayne Garland | Mark Fidrych | | 524 | 516 | 8 |
| 1976-09-08 | vs CLE | 137 | W 3-1 | 73-64 | 2 | 4,547 | Jim Palmer | Dennis Eckersley | Jim Palmer | Dennis Eckersley | | 527 | 517 | 10 |
| 1976-09-09 | vs CLE | 138 | L 3-4 | 73-65 | 2 | 4,622 | Rudy May | Pat Dobson | Pat Dobson | Rudy May | Dave LaRoche | 530 | 521 | 9 |
| 1976-09-10 | vs CLE | 139 | W 4-3 | 74-65 | 2 | 7,081 | Ross Grimsley | Rick Waits | Ross Grimsley | Rick Waits | Dyar Miller | 534 | 524 | 10 |
| 1976-09-11 | @ MIL | 140 | W 5-1 | 76-65 | 2 | 0 | Wayne Garland | Eduardo Rodriguez | Wayne Garland | Eduardo Rodriguez | | 539 | 525 | 14 |
| 1976-09-11 | @ MIL | 141 | W 3-2 | 76-65 | 2 | 9,079 | Mike Flanagan | Jim Colborn | Mike Flanagan | Jim Colborn | | 542 | 527 | 15 |
| 1976-09-12 | @ MIL | 142 | W 3-1 | 77-65 | 2 | 5,193 | Jim Palmer | Jerry Augustine | Jim Palmer | Jerry Augustine | | 545 | 528 | 17 |
| 1976-09-13 | @ MIL | 143 | W 5-3 | 78-65 | 2 | 3,923 | Rudy May | Bill Travers | Fred Holdsworth | Bill Castro | | 550 | 531 | 19 |
| 1976-09-14 | vs DET | 144 | W 9-7 | 79-65 | 2 | 4,516 | Ross Grimsley | Vern Ruhle | Dennis Martinez | John Hiller | | 559 | 538 | 21 |
| 1976-09-15 | vs DET | 145 | W 1-0 | 80-65 | 2 | 2,721 | Wayne Garland | Dave Roberts | Wayne Garland | Dave Roberts | | 560 | 538 | 22 |
| 1976-09-18 | @ CLE | 146 | L 1-5 | 81-66 | 2 | 0 | Jim Palmer | Stan Thomas | Stan Thomas | Jim Palmer | Jim Kern | 561 | 543 | 18 |
| 1976-09-18 | @ CLE | 147 | W 3-2 | 81-66 | 2 | 7,714 | Rudy May | Jim Bibby | Rudy May | Jim Bibby | Tippy Martinez | 564 | 545 | 19 |
| 1976-09-19 | @ CLE | 148 | L 4-5 | 81-68 | 2 | 0 | Wayne Garland | Pat Dobson | Pat Dobson | Wayne Garland | Dave LaRoche | 568 | 550 | 18 |
| 1976-09-19 | @ CLE | 149 | L 2-3 | 81-68 | 2 | 9,616 | Mike Flanagan | Dennis Eckersley | Jim Kern | Dyar Miller | | 570 | 553 | 17 |
| 1976-09-21 | @ NYA | 150 | W 11-8 | 82-68 | 2 | 16,160 | Ross Grimsley | Doyle Alexander | Tippy Martinez | Dick Tidrow | | 581 | 561 | 20 |
| 1976-09-22 | @ NYA | 151 | W 2-0 | 84-68 | 2 | 0 | Jim Palmer | Dock Ellis | Jim Palmer | Dock Ellis | | 583 | 561 | 22 |
| 1976-09-22 | @ NYA | 152 | W 5-2 | 84-68 | 2 | 31,471 | Rudy May | Ed Figueroa | Rudy May | Ed Figueroa | Tippy Martinez | 588 | 563 | 25 |
| 1976-09-23 | @ NYA | 153 | W 2-1 | 85-68 | 2 | 17,238 | Mike Flanagan | Catfish Hunter | Mike Flanagan | Catfish Hunter | | 590 | 564 | 26 |
| 1976-09-24 | vs BOS | 154 | W 3-0 | 86-68 | 2 | 7,285 | Wayne Garland | Rick Wise | Wayne Garland | Rick Wise | | 593 | 564 | 29 |
| 1976-09-25 | vs BOS | 155 | L 0-1 | 86-69 | 2 | 10,562 | Ross Grimsley | Luis Tiant | Luis Tiant | Ross Grimsley | | 593 | 565 | 28 |
| 1976-09-26 | vs BOS | 156 | L 3-8 | 86-70 | 2 | 8,272 | Dennis Martinez | Reggie Cleveland | Reggie Cleveland | Dennis Martinez | | 596 | 573 | 23 |
| 1976-09-28 | vs MIL | 157 | W 7-5 | 88-70 | 2 | 0 | Wayne Garland | Moose Haas | Wayne Garland | Eduardo Rodriguez | | 603 | 578 | 25 |
| 1976-09-28 | vs MIL | 158 | W 7-3 | 88-70 | 2 | 4,598 | Rudy May | Jim Colborn | Rudy May | Jim Colborn | | 610 | 581 | 29 |
| 1976-09-29 | vs MIL | 159 | L 3-6 | 88-71 | 2 | 8,119 | Scott McGregor | Jerry Augustine | Jerry Augustine | Scott McGregor | Bill Castro | 613 | 587 | 26 |
| 1976-10-01 | @ BOS | 160 | L 4-7 | 88-72 | 2 | 15,749 | Dave Pagan | Rick Wise | Rick Wise | Fred Holdsworth | Jim Willoughby | 617 | 594 | 23 |
| 1976-10-02 | @ BOS | 161 | L 0-1 | 88-73 | 2 | 12,753 | Dennis Martinez | Reggie Cleveland | Reggie Cleveland | Dennis Martinez | Jim Willoughby | 617 | 595 | 22 |
| 1976-10-03 | @ BOS | 162 | L 2-3 | 88-74 | 2 | 19,845 | Scott McGregor | Luis Tiant | Jim Willoughby | Mike Flanagan | | 619 | 598 | 21 |