| 1976-04-09 | vs MIN | 1 | W 2-1 | 1-0 | 3 | 28,947 | Gaylord Perry | Bert Blyleven | Gaylord Perry | Bill Campbell | | 2 | 1 | 1 |
| 1976-04-10 | vs MIN | 2 | W 4-1 | 2-0 | 3 | 13,005 | Jim Umbarger | Joe Decker | Jim Umbarger | Joe Decker | | 6 | 2 | 4 |
| 1976-04-11 | vs MIN | 3 | L 3-4 | 2-1 | 3 | 11,781 | Bill Singer | Dave Goltz | Bill Campbell | Jeff Terpko | | 9 | 6 | 3 |
| 1976-04-12 | vs OAK | 4 | W 5-1 | 3-1 | 3 | 6,219 | Nelson Briles | Paul Mitchell | Nelson Briles | Paul Mitchell | | 14 | 7 | 7 |
| 1976-04-13 | vs OAK | 5 | W 3-1 | 4-1 | 2 | 9,321 | Steve Barr | Mike Torrez | Steve Barr | Mike Torrez | | 17 | 8 | 9 |
| 1976-04-14 | vs OAK | 6 | W 4-2 | 5-1 | 1 | 22,920 | Gaylord Perry | Vida Blue | Gaylord Perry | Vida Blue | | 21 | 10 | 11 |
| 1976-04-16 | vs MIL | 7 | L 1-3 | 5-2 | 2 | 22,205 | Jim Umbarger | Jim Colborn | Jim Colborn | Jim Umbarger | Eduardo Rodriguez | 22 | 13 | 9 |
| 1976-04-18 | vs MIL | 8 | W 7-4 | 6-3 | 2 | 0 | Bill Singer | Jim Slaton | Bill Singer | Jim Slaton | Steve Foucault | 29 | 17 | 12 |
| 1976-04-18 | vs MIL | 9 | L 1-4 | 6-3 | 2 | 13,944 | Nelson Briles | Bill Travers | Bill Travers | Nelson Briles | Eduardo Rodriguez | 30 | 21 | 9 |
| 1976-04-20 | @ CLE | 10 | L 1-9 | 6-4 | 2 | 9,328 | Gaylord Perry | Jim Bibby | Jim Bibby | Gaylord Perry | Jim Kern | 31 | 30 | 1 |
| 1976-04-23 | @ DET | 11 | L 6-7 | 6-5 | 1 | 10,754 | Jim Umbarger | Ray Bare | John Hiller | Steve Barr | | 37 | 37 | 0 |
| 1976-04-24 | @ DET | 12 | W 5-4 | 7-5 | 1 | 8,862 | Bill Singer | Vern Ruhle | Steve Foucault | John Hiller | | 42 | 41 | 1 |
| 1976-04-27 | vs NYA | 13 | L 0-1 | 7-6 | 1 | 20,019 | Gaylord Perry | Dock Ellis | Dock Ellis | Gaylord Perry | Sparky Lyle | 42 | 42 | 0 |
| 1976-04-29 | vs BOS | 14 | W 6-1 | 8-6 | 1 | 7,394 | Nelson Briles | Bill Lee | Nelson Briles | Bill Lee | | 48 | 43 | 5 |
| 1976-04-30 | vs BOS | 15 | W 6-5 | 9-6 | 1 | 14,471 | Jim Umbarger | Fergie Jenkins | Jim Umbarger | Fergie Jenkins | Joe Hoerner | 54 | 48 | 6 |
| 1976-05-01 | vs BOS | 16 | W 7-1 | 10-6 | 1 | 22,486 | Bill Singer | Rick Wise | Bill Singer | Rick Wise | | 61 | 49 | 12 |
| 1976-05-02 | vs BOS | 17 | W 6-3 | 11-6 | 1 | 24,464 | Gaylord Perry | Luis Tiant | Gaylord Perry | Luis Tiant | | 67 | 52 | 15 |
| 1976-05-04 | @ MIL | 18 | W 7-4 | 12-6 | 1 | 6,111 | Nelson Briles | Jim Colborn | Nelson Briles | Jim Colborn | Steve Foucault | 74 | 56 | 18 |
| 1976-05-08 | @ BOS | 19 | W 6-5 | 14-6 | 1 | 0 | Bill Singer | Rick Wise | Steve Hargan | Dick Pole | Joe Hoerner | 80 | 61 | 19 |
| 1976-05-08 | @ BOS | 20 | W 12-4 | 14-6 | 1 | 23,737 | Jim Umbarger | Luis Tiant | Jim Umbarger | Luis Tiant | | 92 | 65 | 27 |
| 1976-05-09 | @ BOS | 21 | W 6-5 | 15-6 | 1 | 18,618 | Gaylord Perry | Bill Lee | Steve Foucault | Jim Willoughby | | 98 | 70 | 28 |
| 1976-05-10 | vs CHA | 22 | L 6-7 | 15-7 | 1 | 15,333 | Nelson Briles | Rich Gossage | Dave Hamilton | Steve Hargan | | 104 | 77 | 27 |
| 1976-05-11 | vs CHA | 23 | W 6-5 | 16-7 | 1 | 14,713 | Steve Barr | Terry Forster | Jeff Terpko | Dave Hamilton | | 110 | 82 | 28 |
| 1976-05-12 | @ CAL | 24 | W 1-0 | 17-7 | 1 | 8,539 | Bill Singer | Don Kirkwood | Bill Singer | Don Kirkwood | | 111 | 82 | 29 |
| 1976-05-13 | @ CAL | 25 | L 5-7 | 17-8 | 1 | 8,287 | Jim Umbarger | Frank Tanana | Frank Tanana | Jim Umbarger | Paul Hartzell | 116 | 89 | 27 |
| 1976-05-14 | @ OAK | 26 | W 4-3 | 18-8 | 1 | 5,196 | Gaylord Perry | Mike Torrez | Gaylord Perry | Rollie Fingers | | 120 | 92 | 28 |
| 1976-05-15 | @ OAK | 27 | W 6-4 | 19-8 | 1 | 5,039 | Nelson Briles | Paul Mitchell | Steve Foucault | Jim Todd | | 126 | 96 | 30 |
| 1976-05-16 | @ OAK | 28 | L 2-3 | 19-9 | 1 | 4,940 | Steve Barr | Vida Blue | Vida Blue | Steve Barr | | 128 | 99 | 29 |
| 1976-05-17 | @ KCA | 29 | L 7-8 | 19-10 | 1 | 18,936 | Bill Singer | Dennis Leonard | Tom Hall | Steve Foucault | | 135 | 107 | 28 |
| 1976-05-18 | @ KCA | 30 | L 1-3 | 19-11 | 2 | 14,116 | Jim Umbarger | Al Fitzmorris | Al Fitzmorris | Jim Umbarger | | 136 | 110 | 26 |
| 1976-05-20 | vs CAL | 31 | L 3-6 | 19-12 | 2 | 12,116 | Gaylord Perry | Gary Ross | Gary Ross | Gaylord Perry | Jim Brewer | 139 | 116 | 23 |
| 1976-05-21 | vs CAL | 32 | W 5-2 | 20-12 | 2 | 40,854 | Nelson Briles | Don Kirkwood | Nelson Briles | Don Kirkwood | | 144 | 118 | 26 |
| 1976-05-22 | vs CAL | 33 | L 1-5 | 20-13 | 2 | 25,332 | Bill Singer | Frank Tanana | Frank Tanana | Bill Singer | | 145 | 123 | 22 |
| 1976-05-23 | vs CAL | 34 | W 9-0 | 21-13 | 2 | 22,403 | Jim Umbarger | Nolan Ryan | Jim Umbarger | Nolan Ryan | | 154 | 123 | 31 |
| 1976-05-24 | vs KCA | 35 | L 11-14 | 21-14 | 2 | 12,751 | Steve Barr | Doug Bird | Steve Mingori | Steve Barr | | 165 | 137 | 28 |
| 1976-05-26 | vs KCA | 36 | L 2-14 | 22-15 | 2 | 0 | Gaylord Perry | Dennis Leonard | Dennis Leonard | Gaylord Perry | | 167 | 151 | 16 |
| 1976-05-26 | vs KCA | 37 | W 5-4 | 22-15 | 2 | 16,510 | Nelson Briles | Al Fitzmorris | Steve Foucault | Marty Pattin | | 172 | 155 | 17 |
| 1976-05-27 | vs KCA | 38 | W 6-4 | 23-15 | 2 | 14,755 | Bill Singer | Paul Splittorff | Bill Singer | Paul Splittorff | Joe Hoerner | 178 | 159 | 19 |
| 1976-05-28 | @ MIN | 39 | W 4-0 | 24-15 | 2 | 4,241 | Jim Umbarger | Steve Luebber | Jim Umbarger | Steve Luebber | | 182 | 159 | 23 |
| 1976-05-29 | @ MIN | 40 | L 1-5 | 24-16 | 2 | 6,112 | Steve Hargan | Jim Hughes | Jim Hughes | Steve Hargan | | 183 | 164 | 19 |
| 1976-05-30 | @ MIN | 41 | L 3-4 | 24-17 | 2 | 8,998 | Gaylord Perry | Dave Goltz | Dave Goltz | Steve Foucault | | 186 | 168 | 18 |
| 1976-05-31 | @ CHA | 42 | L 4-9 | 24-18 | 2 | 16,065 | Nelson Briles | Pete Vuckovich | Pete Vuckovich | Nelson Briles | | 190 | 177 | 13 |
| 1976-06-01 | @ CHA | 43 | W 6-5 | 25-18 | 2 | 8,736 | Bill Singer | Ken Brett | Steve Foucault | Jesse Jefferson | | 196 | 182 | 14 |
| 1976-06-02 | @ CHA | 44 | L 0-1 | 25-19 | 2 | 8,013 | Jim Umbarger | Bart Johnson | Dave Hamilton | Jim Umbarger | | 196 | 183 | 13 |
| 1976-06-04 | vs DET | 45 | W 14-3 | 26-19 | 2 | 24,978 | Gaylord Perry | Bill Laxton | Gaylord Perry | Bill Laxton | | 210 | 186 | 24 |
| 1976-06-05 | vs DET | 46 | L 2-3 | 26-20 | 2 | 32,678 | Bert Blyleven | Mark Fidrych | Mark Fidrych | Bert Blyleven | | 212 | 189 | 23 |
| 1976-06-06 | vs DET | 47 | W 16-6 | 27-20 | 2 | 18,171 | Nelson Briles | Joe Coleman | Nelson Briles | Joe Coleman | | 228 | 195 | 33 |
| 1976-06-07 | @ BAL | 48 | W 6-4 | 28-20 | 2 | 11,626 | Jim Umbarger | Ross Grimsley | Jim Umbarger | Ross Grimsley | Steve Foucault | 234 | 199 | 35 |
| 1976-06-08 | @ BAL | 49 | W 6-3 | 29-20 | 2 | 10,006 | Fritz Peterson | Doyle Alexander | Fritz Peterson | Doyle Alexander | Steve Foucault | 240 | 202 | 38 |
| 1976-06-09 | @ BAL | 50 | W 4-1 | 30-20 | 2 | 8,379 | Gaylord Perry | Ken Holtzman | Gaylord Perry | Ken Holtzman | | 244 | 203 | 41 |
| 1976-06-11 | @ NYA | 51 | L 5-7 | 30-21 | 2 | 24,315 | Bert Blyleven | Ed Figueroa | Tippy Martinez | Bert Blyleven | | 249 | 210 | 39 |
| 1976-06-12 | @ NYA | 52 | W 2-1 | 31-21 | 2 | 27,158 | Nelson Briles | Dave Pagan | Nelson Briles | Dave Pagan | Joe Hoerner | 251 | 211 | 40 |
| 1976-06-13 | @ NYA | 53 | W 7-1 | 32-21 | 2 | 34,262 | Jim Umbarger | Catfish Hunter | Jim Umbarger | Catfish Hunter | | 258 | 212 | 46 |
| 1976-06-15 | vs CLE | 54 | W 3-2 | 33-21 | 2 | 18,466 | Gaylord Perry | Jim Bibby | Gaylord Perry | Jim Bibby | | 261 | 214 | 47 |
| 1976-06-16 | vs CLE | 55 | L 4-9 | 33-22 | 2 | 18,006 | Bert Blyleven | Jackie Brown | Jackie Brown | Bert Blyleven | | 265 | 223 | 42 |
| 1976-06-17 | vs BAL | 56 | L 1-4 | 33-23 | 2 | 15,400 | Nelson Briles | Wayne Garland | Wayne Garland | Nelson Briles | Dave Pagan | 266 | 227 | 39 |
| 1976-06-18 | vs BAL | 57 | L 4-9 | 33-24 | 2 | 32,001 | Jim Umbarger | Rudy May | Rudy May | Jim Umbarger | | 270 | 236 | 34 |
| 1976-06-19 | vs BAL | 58 | L 4-8 | 33-25 | 2 | 23,652 | Fritz Peterson | Jim Palmer | Jim Palmer | Steve Foucault | | 274 | 244 | 30 |
| 1976-06-20 | vs BAL | 59 | L 0-2 | 33-26 | 2 | 20,081 | Gaylord Perry | Mike Cuellar | Mike Cuellar | Gaylord Perry | | 274 | 246 | 28 |
| 1976-06-21 | @ OAK | 60 | W 1-0 | 34-26 | 2 | 21,800 | Bert Blyleven | Paul Mitchell | Bert Blyleven | Paul Mitchell | | 275 | 246 | 29 |
| 1976-06-22 | @ OAK | 61 | L 2-5 | 34-27 | 2 | 4,811 | Nelson Briles | Dick Bosman | Dick Bosman | Nelson Briles | Paul Lindblad | 277 | 251 | 26 |
| 1976-06-23 | vs KCA | 62 | W 7-5 | 35-27 | 2 | 21,336 | Jim Umbarger | Dennis Leonard | Steve Foucault | Dennis Leonard | | 284 | 256 | 28 |
| 1976-06-24 | vs KCA | 63 | W 5-2 | 36-27 | 2 | 14,455 | Steve Hargan | Al Fitzmorris | Steve Hargan | Al Fitzmorris | Joe Hoerner | 289 | 258 | 31 |
| 1976-06-25 | vs CHA | 64 | W 8-4 | 37-28 | 2 | 0 | Gaylord Perry | Terry Forster | Gaylord Perry | Dave Hamilton | | 297 | 262 | 35 |
| 1976-06-25 | vs CHA | 65 | L 9-14 | 37-28 | 2 | 29,049 | Steve Barr | Francisco Barrios | Pete Vuckovich | Steve Foucault | | 306 | 276 | 30 |
| 1976-06-26 | vs CHA | 66 | W 1-0 | 38-28 | 2 | 20,903 | Bert Blyleven | Ken Brett | Bert Blyleven | Ken Brett | | 307 | 276 | 31 |
| 1976-06-27 | vs CHA | 67 | L 2-6 | 38-29 | 2 | 12,567 | Nelson Briles | Bart Johnson | Bart Johnson | Nelson Briles | Dave Hamilton | 309 | 282 | 27 |
| 1976-06-28 | vs OAK | 68 | W 3-2 | 39-29 | 2 | 13,679 | Jim Umbarger | Mike Norris | Steve Foucault | Jim Todd | | 312 | 284 | 28 |
| 1976-06-29 | vs OAK | 69 | L 3-8 | 39-30 | 2 | 13,964 | Steve Barr | Glenn Abbott | Stan Bahnsen | Steve Barr | Rollie Fingers | 315 | 292 | 23 |
| 1976-06-30 | vs OAK | 70 | W 3-2 | 40-30 | 2 | 14,936 | Gaylord Perry | Mike Torrez | Gaylord Perry | Mike Torrez | Steve Foucault | 318 | 294 | 24 |
| 1976-07-02 | @ CHA | 71 | L 0-1 | 40-31 | 2 | 17,162 | Bert Blyleven | Bart Johnson | Bart Johnson | Bert Blyleven | | 318 | 295 | 23 |
| 1976-07-03 | @ CHA | 72 | W 3-0 | 41-31 | 2 | 10,099 | Nelson Briles | Terry Forster | Nelson Briles | Terry Forster | | 321 | 295 | 26 |
| 1976-07-04 | @ CHA | 73 | L 6-7 | 42-32 | 2 | 0 | Jim Umbarger | Francisco Barrios | Dave Hamilton | Mike Bacsik | | 327 | 302 | 25 |
| 1976-07-04 | @ CHA | 74 | W 3-2 | 42-32 | 2 | 15,689 | Steve Hargan | Chris Knapp | Steve Hargan | Chris Knapp | Joe Hoerner | 330 | 304 | 26 |
| 1976-07-05 | vs DET | 75 | W 8-6 | 43-32 | 2 | 33,847 | Gaylord Perry | Dave Roberts | Jeff Terpko | Dave Roberts | | 338 | 310 | 28 |
| 1976-07-06 | vs DET | 76 | W 3-2 | 44-32 | 2 | 15,873 | Steve Barr | Vern Ruhle | Steve Barr | Vern Ruhle | | 341 | 312 | 29 |
| 1976-07-07 | vs DET | 77 | L 1-2 | 44-33 | 2 | 20,052 | Bert Blyleven | Dave Lemanczyk | John Hiller | Bert Blyleven | Steve Grilli | 342 | 314 | 28 |
| 1976-07-08 | @ MIL | 78 | L 4-5 | 44-34 | 2 | 5,181 | Nelson Briles | Jim Colborn | Danny Frisella | Joe Hoerner | | 346 | 319 | 27 |
| 1976-07-09 | @ MIL | 79 | L 2-7 | 44-35 | 2 | 22,912 | Jim Umbarger | Pete Broberg | Eduardo Rodriguez | Jim Umbarger | | 348 | 326 | 22 |
| 1976-07-10 | @ MIL | 80 | L 1-3 | 44-36 | 2 | 25,170 | Gaylord Perry | Bill Travers | Bill Travers | Gaylord Perry | Danny Frisella | 349 | 329 | 20 |
| 1976-07-11 | @ MIL | 81 | L 3-6 | 44-38 | 2 | 0 | Bert Blyleven | Jim Slaton | Jim Slaton | Bert Blyleven | | 352 | 335 | 17 |
| 1976-07-11 | @ MIL | 82 | L 4-5 | 44-38 | 2 | 28,149 | Steve Barr | Jerry Augustine | Bill Castro | Steve Foucault | | 356 | 340 | 16 |
| 1976-07-15 | vs NYA | 83 | L 6-7 | 44-40 | 2 | 0 | Gaylord Perry | Ed Figueroa | Ed Figueroa | Gaylord Perry | Dick Tidrow | 362 | 347 | 15 |
| 1976-07-15 | vs NYA | 84 | L 4-6 | 44-40 | 2 | 25,039 | Nelson Briles | Catfish Hunter | Catfish Hunter | Joe Hoerner | Dick Tidrow | 366 | 353 | 13 |
| 1976-07-16 | vs NYA | 85 | L 0-3 | 44-41 | 2 | 21,930 | Bert Blyleven | Ken Holtzman | Ken Holtzman | Bert Blyleven | | 366 | 356 | 10 |
| 1976-07-17 | vs NYA | 86 | L 5-7 | 44-42 | 2 | 32,605 | Steve Barr | Dock Ellis | Dock Ellis | Steve Barr | Dick Tidrow | 371 | 363 | 8 |
| 1976-07-18 | vs NYA | 87 | W 3-2 | 45-42 | 2 | 13,736 | Steve Hargan | Doyle Alexander | Steve Hargan | Sparky Lyle | | 374 | 365 | 9 |
| 1976-07-19 | vs BOS | 88 | W 4-3 | 46-42 | 2 | 11,166 | Tommy Boggs | Dick Pole | Mike Bacsik | Jim Willoughby | | 378 | 368 | 10 |
| 1976-07-20 | vs BOS | 89 | L 2-4 | 46-43 | 3 | 13,495 | Nelson Briles | Rick Jones | Rick Jones | Nelson Briles | Jim Willoughby | 380 | 372 | 8 |
| 1976-07-21 | vs BAL | 90 | L 4-6 | 46-44 | 3 | 10,273 | Bert Blyleven | Dave Pagan | Tippy Martinez | Joe Hoerner | Fred Holdsworth | 384 | 378 | 6 |
| 1976-07-22 | vs BAL | 91 | L 3-4 | 46-45 | 3 | 10,336 | Gaylord Perry | Ross Grimsley | Fred Holdsworth | Gaylord Perry | | 387 | 382 | 5 |
| 1976-07-24 | @ CAL | 92 | L 0-8 | 46-47 | 3 | 0 | Jim Umbarger | Paul Hartzell | Paul Hartzell | Jim Umbarger | | 387 | 390 | -3 |
| 1976-07-24 | @ CAL | 93 | L 3-4 | 46-47 | 3 | 12,716 | Tommy Boggs | Don Kirkwood | Don Kirkwood | Tommy Boggs | John Verhoeven | 390 | 394 | -4 |
| 1976-07-25 | @ CAL | 94 | L 3-7 | 46-48 | 3 | 8,532 | Nelson Briles | Gary Ross | Dick Drago | Steve Foucault | | 393 | 401 | -8 |
| 1976-07-26 | @ MIN | 95 | W 3-0 | 47-48 | 3 | 9,184 | Bert Blyleven | Dave Goltz | Bert Blyleven | Dave Goltz | | 396 | 401 | -5 |
| 1976-07-28 | @ MIN | 96 | L 5-8 | 47-50 | 4 | 0 | Steve Hargan | Jim Hughes | Jim Hughes | Steve Hargan | Bill Campbell | 401 | 409 | -8 |
| 1976-07-28 | @ MIN | 97 | L 0-8 | 47-50 | 4 | 5,983 | Steve Barr | Steve Luebber | Steve Luebber | Steve Barr | | 401 | 417 | -16 |
| 1976-07-29 | @ MIN | 98 | L 1-2 | 47-51 | 4 | 14,203 | Jim Umbarger | Eddie Bane | Eddie Bane | Jim Umbarger | Bill Campbell | 402 | 419 | -17 |
| 1976-07-30 | @ KCA | 99 | L 1-2 | 47-52 | 4 | 28,411 | Nelson Briles | Dennis Leonard | Dennis Leonard | Nelson Briles | Mark Littell | 403 | 421 | -18 |
| 1976-07-31 | @ KCA | 100 | W 4-2 | 48-52 | 4 | 35,786 | Bert Blyleven | Al Fitzmorris | Bert Blyleven | Al Fitzmorris | | 407 | 423 | -16 |
| 1976-08-01 | @ KCA | 101 | W 8-4 | 49-52 | 4 | 24,732 | Gaylord Perry | Andy Hassler | Gaylord Perry | Andy Hassler | | 415 | 427 | -12 |
| 1976-08-03 | vs CAL | 102 | L 0-4 | 49-53 | 4 | 10,301 | Jim Umbarger | Paul Hartzell | Paul Hartzell | Jim Umbarger | | 415 | 431 | -16 |
| 1976-08-04 | vs CAL | 103 | L 6-9 | 49-54 | 4 | 9,489 | Nelson Briles | Nolan Ryan | Nolan Ryan | Nelson Briles | | 421 | 440 | -19 |
| 1976-08-05 | vs CAL | 104 | W 1-0 | 50-54 | 4 | 9,679 | Bert Blyleven | Gary Ross | Bert Blyleven | Gary Ross | | 422 | 440 | -18 |
| 1976-08-06 | vs MIN | 105 | W 6-0 | 51-54 | 4 | 23,078 | Gaylord Perry | Pete Redfern | Gaylord Perry | Pete Redfern | | 428 | 440 | -12 |
| 1976-08-07 | vs MIN | 106 | L 1-3 | 51-55 | 4 | 11,954 | Tommy Boggs | Steve Luebber | Steve Luebber | Tommy Boggs | Bill Campbell | 429 | 443 | -14 |
| 1976-08-08 | vs MIN | 107 | W 5-4 | 52-55 | 4 | 7,855 | Jim Umbarger | Eddie Bane | Jeff Terpko | Bill Campbell | | 434 | 447 | -13 |
| 1976-08-09 | @ DET | 108 | W 8-1 | 53-55 | 4 | 14,963 | Nelson Briles | Dave Lemanczyk | Nelson Briles | Dave Lemanczyk | | 442 | 448 | -6 |
| 1976-08-10 | @ DET | 109 | L 5-7 | 54-56 | 4 | 0 | Bert Blyleven | Dave Roberts | Dave Lemanczyk | Jeff Terpko | | 447 | 455 | -8 |
| 1976-08-10 | @ DET | 110 | W 3-0 | 54-56 | 4 | 15,028 | Steve Hargan | Jim Crawford | Steve Hargan | Jim Crawford | | 450 | 455 | -5 |
| 1976-08-11 | @ DET | 111 | L 3-4 | 54-57 | 4 | 36,523 | Gaylord Perry | Mark Fidrych | Mark Fidrych | Gaylord Perry | | 453 | 459 | -6 |
| 1976-08-12 | @ CLE | 112 | L 4-5 | 54-58 | 4 | 3,786 | Tommy Boggs | Pat Dobson | Dave LaRoche | Jeff Terpko | | 457 | 464 | -7 |
| 1976-08-13 | @ CLE | 113 | W 2-1 | 55-58 | 4 | 11,954 | Jim Umbarger | Dennis Eckersley | Jim Umbarger | Dennis Eckersley | | 459 | 465 | -6 |
| 1976-08-14 | @ CLE | 114 | W 4-3 | 56-58 | 3 | 13,640 | Nelson Briles | Rick Waits | Steve Foucault | Jim Kern | | 463 | 468 | -5 |
| 1976-08-15 | @ CLE | 115 | L 4-6 | 56-60 | 4 | 0 | Bert Blyleven | Stan Thomas | Stan Thomas | Bert Blyleven | Jim Kern | 467 | 474 | -7 |
| 1976-08-15 | @ CLE | 116 | L 0-3 | 56-60 | 4 | 23,790 | Steve Hargan | Jim Bibby | Jim Bibby | Steve Hargan | | 467 | 477 | -10 |
| 1976-08-16 | @ NYA | 117 | L 1-5 | 56-61 | 4 | 21,621 | Gaylord Perry | Catfish Hunter | Catfish Hunter | Gaylord Perry | | 468 | 482 | -14 |
| 1976-08-17 | @ NYA | 118 | L 1-2 | 56-62 | 4 | 20,959 | Tommy Boggs | Doyle Alexander | Doyle Alexander | Tommy Boggs | | 469 | 484 | -15 |
| 1976-08-18 | @ NYA | 119 | L 6-8 | 56-63 | 4 | 23,358 | Jim Umbarger | Ken Holtzman | Sparky Lyle | Steve Hargan | | 475 | 492 | -17 |
| 1976-08-19 | vs CLE | 120 | L 5-7 | 56-64 | 4 | 20,076 | Nelson Briles | Rick Waits | Tom Buskey | Craig Skok | Dave LaRoche | 480 | 499 | -19 |
| 1976-08-20 | vs CLE | 121 | W 3-0 | 57-64 | 4 | 7,964 | Bert Blyleven | Jim Bibby | Bert Blyleven | Jim Bibby | | 483 | 499 | -16 |
| 1976-08-21 | vs CLE | 122 | W 5-3 | 58-64 | 4 | 12,696 | Gaylord Perry | Jackie Brown | Gaylord Perry | Jackie Brown | | 488 | 502 | -14 |
| 1976-08-22 | vs CLE | 123 | L 1-3 | 58-65 | 4 | 5,654 | Tommy Boggs | Pat Dobson | Pat Dobson | Tommy Boggs | Dave LaRoche | 489 | 505 | -16 |
| 1976-08-23 | vs MIL | 124 | L 2-6 | 58-66 | 4 | 5,283 | Jim Umbarger | Eduardo Rodriguez | Eduardo Rodriguez | Jim Umbarger | Bill Castro | 491 | 511 | -20 |
| 1976-08-24 | vs MIL | 125 | L 0-1 | 58-67 | 4 | 6,370 | Nelson Briles | Jerry Augustine | Jerry Augustine | Steve Foucault | | 491 | 512 | -21 |
| 1976-08-25 | vs MIL | 126 | L 1-5 | 58-68 | 4 | 6,121 | Bert Blyleven | Bill Travers | Bill Travers | Bert Blyleven | Bill Castro | 492 | 517 | -25 |
| 1976-08-27 | @ BAL | 127 | L 0-3 | 58-69 | 4 | 6,418 | Gaylord Perry | Jim Palmer | Jim Palmer | Gaylord Perry | | 492 | 520 | -28 |
| 1976-08-28 | @ BAL | 128 | L 4-6 | 58-70 | 4 | 47,153 | Tommy Boggs | Mike Flanagan | Fred Holdsworth | Steve Hargan | | 496 | 526 | -30 |
| 1976-08-29 | @ BAL | 129 | W 11-0 | 59-70 | 4 | 7,922 | Jim Umbarger | Wayne Garland | Jim Umbarger | Wayne Garland | | 507 | 526 | -19 |
| 1976-08-30 | @ BOS | 130 | L 3-11 | 59-71 | 4 | 17,101 | Bert Blyleven | Luis Tiant | Luis Tiant | Bert Blyleven | | 510 | 537 | -27 |
| 1976-08-31 | @ BOS | 131 | W 8-3 | 60-71 | 4 | 18,145 | Nelson Briles | Reggie Cleveland | Nelson Briles | Reggie Cleveland | | 518 | 540 | -22 |
| 1976-09-01 | @ BOS | 132 | L 0-3 | 60-72 | 4 | 19,330 | Gaylord Perry | Fergie Jenkins | Tom Murphy | Gaylord Perry | | 518 | 543 | -25 |
| 1976-09-03 | @ KCA | 133 | W 4-1 | 61-72 | 4 | 17,748 | Tommy Boggs | Al Fitzmorris | Tommy Boggs | Al Fitzmorris | | 522 | 544 | -22 |
| 1976-09-04 | @ KCA | 134 | L 0-7 | 61-73 | 4 | 31,541 | Jim Umbarger | Dennis Leonard | Dennis Leonard | Jim Umbarger | | 522 | 551 | -29 |
| 1976-09-05 | @ KCA | 135 | W 3-1 | 62-73 | 4 | 22,025 | Bert Blyleven | Andy Hassler | Bert Blyleven | Andy Hassler | | 525 | 552 | -27 |
| 1976-09-06 | @ KCA | 136 | W 5-4 | 63-73 | 4 | 27,008 | Nelson Briles | Doug Bird | Steve Hargan | Doug Bird | Joe Hoerner | 530 | 556 | -26 |
| 1976-09-07 | vs MIN | 137 | L 0-1 | 63-74 | 4 | 4,640 | Gaylord Perry | Pete Redfern | Pete Redfern | Gaylord Perry | Bill Campbell | 530 | 557 | -27 |
| 1976-09-08 | vs MIN | 138 | L 1-3 | 63-75 | 4 | 3,777 | Tommy Boggs | Steve Luebber | Steve Luebber | Tommy Boggs | | 531 | 560 | -29 |
| 1976-09-09 | vs MIN | 139 | L 0-6 | 63-76 | 4 | 3,603 | Jim Umbarger | Dave Goltz | Dave Goltz | Jim Umbarger | | 531 | 566 | -35 |
| 1976-09-10 | vs OAK | 140 | W 5-4 | 64-76 | 4 | 7,297 | Bert Blyleven | Vida Blue | Mike Bacsik | Vida Blue | | 536 | 570 | -34 |
| 1976-09-11 | vs OAK | 141 | L 0-1 | 64-77 | 5 | 9,554 | Nelson Briles | Mike Torrez | Mike Torrez | Nelson Briles | | 536 | 571 | -35 |
| 1976-09-12 | vs OAK | 142 | L 6-9 | 64-78 | 5 | 5,070 | Gaylord Perry | Stan Bahnsen | Stan Bahnsen | Gaylord Perry | Jim Todd | 542 | 580 | -38 |
| 1976-09-13 | vs CAL | 143 | L 2-6 | 64-79 | 5 | 3,500 | Tommy Boggs | Gary Ross | Dick Drago | Mike Bacsik | | 544 | 586 | -42 |
| 1976-09-14 | vs CAL | 144 | L 4-6 | 64-80 | 5 | 3,736 | Len Barker | Paul Hartzell | Paul Hartzell | Steve Hargan | | 548 | 592 | -44 |
| 1976-09-15 | @ CHA | 145 | W 4-3 | 65-80 | 5 | 3,912 | Bert Blyleven | Bart Johnson | Bert Blyleven | Bart Johnson | | 552 | 595 | -43 |
| 1976-09-16 | @ CHA | 146 | W 5-4 | 66-80 | 5 | 1,826 | Nelson Briles | Ken Kravec | Nelson Briles | Ken Kravec | Joe Hoerner | 557 | 599 | -42 |
| 1976-09-17 | @ OAK | 147 | W 4-3 | 67-80 | 5 | 9,073 | Gaylord Perry | Glenn Abbott | Gaylord Perry | Dick Bosman | | 561 | 602 | -41 |
| 1976-09-18 | @ OAK | 148 | L 2-3 | 67-81 | 5 | 6,014 | Tommy Boggs | Vida Blue | Vida Blue | Tommy Boggs | Paul Lindblad | 563 | 605 | -42 |
| 1976-09-19 | @ OAK | 149 | W 9-1 | 68-82 | 5 | 0 | Jim Umbarger | Mike Torrez | Jim Umbarger | Mike Torrez | | 572 | 606 | -34 |
| 1976-09-19 | @ OAK | 150 | L 3-13 | 68-82 | 5 | 11,421 | Steve Hargan | Paul Mitchell | Paul Mitchell | Steve Hargan | | 575 | 619 | -44 |
| 1976-09-20 | @ CAL | 151 | L 0-1 | 68-83 | 5 | 5,738 | Bert Blyleven | Nolan Ryan | Nolan Ryan | Bert Blyleven | | 575 | 620 | -45 |
| 1976-09-21 | @ CAL | 152 | L 1-2 | 68-84 | 5 | 5,048 | Nelson Briles | Frank Tanana | Frank Tanana | Joe Hoerner | | 576 | 622 | -46 |
| 1976-09-22 | @ CAL | 153 | W 2-1 | 69-84 | 5 | 4,920 | Gaylord Perry | Gary Ross | Gaylord Perry | Gary Ross | | 578 | 623 | -45 |
| 1976-09-23 | @ CAL | 154 | W 6-5 | 70-84 | 5 | 5,044 | Tommy Boggs | Paul Hartzell | Steve Hargan | Dick Drago | | 584 | 628 | -44 |
| 1976-09-24 | vs KCA | 155 | L 1-2 | 70-85 | 5 | 6,949 | Jim Umbarger | Al Fitzmorris | Larry Gura | Steve Foucault | Mark Littell | 585 | 630 | -45 |
| 1976-09-25 | vs KCA | 156 | W 1-0 | 71-85 | 4 | 9,001 | Bert Blyleven | Andy Hassler | Bert Blyleven | Andy Hassler | | 586 | 630 | -44 |
| 1976-09-26 | vs KCA | 157 | W 3-1 | 72-85 | 4 | 4,650 | Nelson Briles | Doug Bird | Nelson Briles | Doug Bird | Steve Hargan | 589 | 631 | -42 |
| 1976-09-28 | @ MIN | 158 | W 7-0 | 73-85 | 4 | 2,122 | Gaylord Perry | Bill Singer | Gaylord Perry | Bill Singer | | 596 | 631 | -35 |
| 1976-09-29 | @ MIN | 159 | L 1-9 | 73-86 | 5 | 2,444 | Tommy Boggs | Pete Redfern | Pete Redfern | Tommy Boggs | | 597 | 640 | -43 |
| 1976-10-01 | vs CHA | 160 | W 11-8 | 74-86 | 5 | 4,907 | Jim Umbarger | Chris Knapp | Steve Hargan | Francisco Barrios | Nelson Briles | 608 | 648 | -40 |
| 1976-10-02 | vs CHA | 161 | W 5-4 | 75-86 | 4 | 9,406 | Bert Blyleven | Bart Johnson | Mike Bacsik | Pete Vuckovich | | 613 | 652 | -39 |
| 1976-10-03 | vs CHA | 162 | W 3-0 | 76-86 | 4 | 4,455 | Len Barker | Rich Gossage | Len Barker | Rich Gossage | | 616 | 652 | -36 |