| 1976-04-10 | @ PHI | 1 | W 5-4 | 1-0 | 2 | 42,147 | Doc Medich | Jim Kaat | Larry Demery | Tug McGraw | | 5 | 4 | 1 |
| 1976-04-11 | @ PHI | 2 | W 8-3 | 2-0 | 1 | 18,373 | Bruce Kison | Steve Carlton | Bruce Kison | Steve Carlton | Bob Moose | 13 | 7 | 6 |
| 1976-04-13 | vs SLN | 3 | W 14-4 | 3-0 | 1 | 40,937 | Jerry Reuss | Pete Falcone | Jerry Reuss | Pete Falcone | | 27 | 11 | 16 |
| 1976-04-15 | vs SLN | 4 | W 9-3 | 4-0 | 1 | 9,490 | Jim Rooker | Lynn McGlothen | Jim Rooker | Lynn McGlothen | Ramon Hernandez | 36 | 14 | 22 |
| 1976-04-16 | vs NYN | 5 | W 3-1 | 5-0 | 1 | 19,899 | Doc Medich | Mickey Lolich | Doc Medich | Mickey Lolich | | 39 | 15 | 24 |
| 1976-04-17 | vs NYN | 6 | L 1-17 | 5-1 | 1 | 13,082 | Bruce Kison | Jerry Koosman | Jerry Koosman | Bruce Kison | | 40 | 32 | 8 |
| 1976-04-18 | vs NYN | 7 | W 7-5 | 6-1 | 1 | 9,106 | Jerry Reuss | Craig Swan | Jerry Reuss | Craig Swan | Ramon Hernandez | 47 | 37 | 10 |
| 1976-04-20 | vs PHI | 8 | L 1-5 | 6-2 | 1 | 8,800 | John Candelaria | Jim Kaat | Jim Kaat | John Candelaria | | 48 | 42 | 6 |
| 1976-04-21 | vs PHI | 9 | L 0-3 | 6-3 | 1 | 9,175 | Doc Medich | Tom Underwood | Tom Underwood | Doc Medich | Tug McGraw | 48 | 45 | 3 |
| 1976-04-23 | @ SFN | 10 | L 3-7 | 6-4 | 1 | 15,621 | Jerry Reuss | John Montefusco | John Montefusco | Jerry Reuss | Gary Lavelle | 51 | 52 | -1 |
| 1976-04-24 | @ SFN | 11 | L 1-3 | 6-5 | 2 | 9,222 | Jim Rooker | Ed Halicki | Ed Halicki | Jim Rooker | Gary Lavelle | 52 | 55 | -3 |
| 1976-04-25 | @ SFN | 12 | W 3-0 | 7-5 | 1 | 23,700 | John Candelaria | Mike Caldwell | John Candelaria | Mike Caldwell | | 55 | 55 | 0 |
| 1976-04-26 | @ LAN | 13 | L 1-7 | 7-6 | 3 | 23,374 | Doc Medich | Tommy John | Tommy John | Doc Medich | | 56 | 62 | -6 |
| 1976-04-27 | @ LAN | 14 | L 3-5 | 7-7 | 3 | 21,612 | Bruce Kison | Doug Rau | Doug Rau | Bruce Kison | Charlie Hough | 59 | 67 | -8 |
| 1976-04-28 | @ LAN | 15 | L 1-2 | 7-8 | 5 | 22,769 | Jerry Reuss | Burt Hooton | Burt Hooton | Jerry Reuss | | 60 | 69 | -9 |
| 1976-04-30 | @ SDN | 16 | W 4-3 | 8-8 | 3 | 17,010 | Jim Rooker | Dan Spillner | Jim Rooker | Dan Spillner | Bob Moose | 64 | 72 | -8 |
| 1976-05-01 | @ SDN | 17 | W 10-6 | 9-8 | 3 | 21,773 | John Candelaria | Bill Greif | John Candelaria | Bill Greif | | 74 | 78 | -4 |
| 1976-05-02 | @ SDN | 18 | L 2-4 | 9-9 | 4 | 21,702 | Doc Medich | Randy Jones | Randy Jones | Doc Medich | | 76 | 82 | -6 |
| 1976-05-04 | vs SFN | 19 | W 6-5 | 10-9 | 3 | 4,729 | Jerry Reuss | Mike Caldwell | Jerry Reuss | Mike Caldwell | Bob Moose | 82 | 87 | -5 |
| 1976-05-05 | vs SFN | 20 | W 6-1 | 11-9 | 3 | 6,321 | Bruce Kison | Ed Halicki | Bruce Kison | Ed Halicki | | 88 | 88 | 0 |
| 1976-05-06 | vs SFN | 21 | W 3-0 | 12-9 | 3 | 5,111 | Jim Rooker | Jim Barr | Jim Rooker | Jim Barr | Larry Demery | 91 | 88 | 3 |
| 1976-05-07 | vs ATL | 22 | W 3-1 | 13-9 | 3 | 6,049 | John Candelaria | Andy Messersmith | John Candelaria | Andy Messersmith | | 94 | 89 | 5 |
| 1976-05-08 | vs ATL | 23 | W 5-3 | 14-9 | 3 | 6,864 | Doc Medich | Phil Niekro | Doc Medich | Phil Niekro | Dave Giusti | 99 | 92 | 7 |
| 1976-05-09 | vs ATL | 24 | W 5-2 | 15-9 | 3 | 9,275 | Jerry Reuss | Dick Ruthven | Jerry Reuss | Dick Ruthven | | 104 | 94 | 10 |
| 1976-05-11 | @ CIN | 25 | L 0-6 | 15-10 | 3 | 26,850 | Bruce Kison | Gary Nolan | Gary Nolan | Bruce Kison | | 104 | 100 | 4 |
| 1976-05-12 | @ CIN | 26 | W 6-3 | 16-10 | 3 | 26,053 | Jim Rooker | Don Gullett | Jim Rooker | Don Gullett | | 110 | 103 | 7 |
| 1976-05-14 | vs LAN | 27 | L 2-3 | 16-11 | 3 | 13,764 | John Candelaria | Tommy John | Charlie Hough | John Candelaria | Mike Marshall | 112 | 106 | 6 |
| 1976-05-15 | vs LAN | 28 | W 4-2 | 17-11 | 2 | 12,165 | Doc Medich | Doug Rau | Doc Medich | Doug Rau | Bob Moose | 116 | 108 | 8 |
| 1976-05-16 | vs LAN | 29 | L 0-6 | 17-12 | 3 | 15,334 | Jerry Reuss | Burt Hooton | Burt Hooton | Jerry Reuss | | 116 | 114 | 2 |
| 1976-05-17 | @ SLN | 30 | W 2-1 | 18-12 | 2 | 10,538 | Bruce Kison | John Curtis | Bruce Kison | John Curtis | Bob Moose | 118 | 115 | 3 |
| 1976-05-18 | @ SLN | 31 | W 4-1 | 19-12 | 2 | 10,288 | Jim Rooker | Bob Forsch | Jim Rooker | Al Hrabosky | | 122 | 116 | 6 |
| 1976-05-19 | @ SLN | 32 | W 7-6 | 20-12 | 2 | 11,229 | John Candelaria | Lynn McGlothen | Ramon Hernandez | Eric Rasmussen | Bob Moose | 129 | 122 | 7 |
| 1976-05-20 | @ SLN | 33 | L 1-4 | 20-13 | 2 | 11,315 | Doc Medich | John Denny | John Denny | Doc Medich | | 130 | 126 | 4 |
| 1976-05-21 | vs CHN | 34 | L 4-5 | 20-14 | 2 | 9,342 | Larry Demery | Rick Reuschel | Rick Reuschel | Larry Demery | Darold Knowles | 134 | 131 | 3 |
| 1976-05-22 | vs CHN | 35 | W 4-3 | 21-14 | 2 | 7,081 | Bruce Kison | Steve Renko | Bob Moose | Paul Reuschel | | 138 | 134 | 4 |
| 1976-05-23 | vs CHN | 36 | L 5-6 | 22-15 | 2 | 0 | Jim Rooker | Bill Bonham | Oscar Zamora | Kent Tekulve | Bruce Sutter | 143 | 140 | 3 |
| 1976-05-23 | vs CHN | 37 | W 9-1 | 22-15 | 2 | 20,477 | Jerry Reuss | Mike Garman | Jerry Reuss | Mike Garman | | 152 | 141 | 11 |
| 1976-05-24 | vs MON | 38 | L 2-4 | 22-16 | 2 | 5,420 | John Candelaria | Woodie Fryman | Woodie Fryman | John Candelaria | Fred Scherman | 154 | 145 | 9 |
| 1976-05-25 | vs MON | 39 | L 3-6 | 22-17 | 2 | 4,805 | Doc Medich | Steve Rogers | Wayne Granger | Bob Moose | | 157 | 151 | 6 |
| 1976-05-26 | vs MON | 40 | W 6-3 | 23-17 | 2 | 6,581 | Larry Demery | Dan Warthen | Larry Demery | Dan Warthen | John Candelaria | 163 | 154 | 9 |
| 1976-05-29 | @ CHN | 41 | L 1-4 | 23-18 | 2 | 12,357 | Bruce Kison | Bill Bonham | Bill Bonham | Bruce Kison | Oscar Zamora | 164 | 158 | 6 |
| 1976-05-30 | @ CHN | 42 | W 4-2 | 24-18 | 2 | 19,410 | Jim Rooker | Ray Burris | Jim Rooker | Ray Burris | | 168 | 160 | 8 |
| 1976-05-31 | @ NYN | 43 | L 2-13 | 25-19 | 2 | 0 | Jerry Reuss | Jon Matlack | Jon Matlack | Jerry Reuss | | 170 | 173 | -3 |
| 1976-05-31 | @ NYN | 44 | W 2-1 | 25-19 | 2 | 46,004 | Doc Medich | Bob Apodaca | Doc Medich | Bob Apodaca | | 172 | 174 | -2 |
| 1976-06-01 | @ NYN | 45 | W 3-2 | 26-19 | 2 | 13,596 | John Candelaria | Jerry Koosman | John Candelaria | Jerry Koosman | | 175 | 176 | -1 |
| 1976-06-02 | @ MON | 46 | W 4-2 | 27-19 | 2 | 11,337 | Bruce Kison | Woodie Fryman | Bruce Kison | Woodie Fryman | Dave Giusti | 179 | 178 | 1 |
| 1976-06-03 | @ MON | 47 | L 1-7 | 27-20 | 2 | 7,951 | Jim Rooker | Don Stanhouse | Don Stanhouse | Jim Rooker | | 180 | 185 | -5 |
| 1976-06-04 | vs SDN | 48 | W 7-2 | 28-20 | 2 | 9,249 | Jerry Reuss | Dave Freisleben | Jerry Reuss | Dave Freisleben | | 187 | 187 | 0 |
| 1976-06-05 | vs SDN | 49 | L 9-11 | 28-21 | 2 | 15,558 | Doc Medich | Randy Jones | Dave Freisleben | Ramon Hernandez | | 196 | 198 | -2 |
| 1976-06-06 | vs SDN | 50 | L 1-6 | 28-22 | 2 | 51,726 | John Candelaria | Brent Strom | Brent Strom | John Candelaria | | 197 | 204 | -7 |
| 1976-06-07 | vs CIN | 51 | W 5-4 | 29-22 | 2 | 16,001 | Bruce Kison | Jack Billingham | Bob Moose | Will McEnaney | Dave Giusti | 202 | 208 | -6 |
| 1976-06-08 | vs CIN | 52 | L 5-10 | 29-23 | 2 | 17,331 | Jim Rooker | Santo Alcala | Santo Alcala | Jim Rooker | Will McEnaney | 207 | 218 | -11 |
| 1976-06-09 | vs CIN | 53 | L 1-6 | 29-24 | 2 | 18,127 | Jerry Reuss | Gary Nolan | Gary Nolan | Jerry Reuss | | 208 | 224 | -16 |
| 1976-06-10 | vs CIN | 54 | L 1-6 | 29-25 | 2 | 17,280 | Doc Medich | Don Gullett | Don Gullett | Doc Medich | | 209 | 230 | -21 |
| 1976-06-11 | @ ATL | 55 | W 6-2 | 30-25 | 2 | 13,687 | John Candelaria | Roger Moret | John Candelaria | Roger Moret | Bob Moose | 215 | 232 | -17 |
| 1976-06-12 | @ ATL | 56 | W 4-2 | 31-25 | 2 | 20,117 | Bruce Kison | Carl Morton | Bob Moose | Adrian Devine | Kent Tekulve | 219 | 234 | -15 |
| 1976-06-13 | @ ATL | 57 | W 6-5 | 32-25 | 2 | 15,656 | Jim Rooker | Phil Niekro | Larry Demery | Max Leon | Bob Moose | 225 | 239 | -14 |
| 1976-06-14 | @ HOU | 58 | W 2-1 | 33-25 | 2 | 9,884 | Jerry Reuss | J.R. Richard | Jerry Reuss | J.R. Richard | | 227 | 240 | -13 |
| 1976-06-16 | @ HOU | 59 | W 6-3 | 34-25 | 2 | 12,249 | Doc Medich | Joaquin Andujar | Doc Medich | Joaquin Andujar | Larry Demery | 233 | 243 | -10 |
| 1976-06-18 | vs HOU | 60 | W 7-3 | 35-25 | 2 | 19,141 | John Candelaria | J.R. Richard | John Candelaria | J.R. Richard | | 240 | 246 | -6 |
| 1976-06-20 | vs HOU | 61 | L 4-9 | 35-26 | 2 | 18,670 | Bruce Kison | Larry Dierker | Tom Griffin | Bob Moose | | 244 | 255 | -11 |
| 1976-06-22 | @ CHN | 62 | W 10-7 | 36-26 | 2 | 10,116 | Jerry Reuss | Bill Bonham | Larry Demery | Darold Knowles | Ramon Hernandez | 254 | 262 | -8 |
| 1976-06-23 | @ CHN | 63 | L 5-6 | 36-27 | 2 | 17,661 | Jim Rooker | Rick Reuschel | Oscar Zamora | Bob Moose | | 259 | 268 | -9 |
| 1976-06-24 | @ CHN | 64 | L 1-2 | 36-28 | 2 | 3,824 | John Candelaria | Steve Renko | Oscar Zamora | Rick Langford | | 260 | 270 | -10 |
| 1976-06-25 | @ MON | 65 | W 9-2 | 37-28 | 2 | 6,581 | Bruce Kison | Don Carrithers | Bruce Kison | Don Carrithers | | 269 | 272 | -3 |
| 1976-06-26 | @ MON | 66 | W 7-6 | 38-28 | 2 | 10,445 | Jerry Reuss | Dan Warthen | Larry Demery | Dale Murray | | 276 | 278 | -2 |
| 1976-06-27 | @ MON | 67 | L 3-4 | 38-29 | 2 | 12,824 | Doc Medich | Woodie Fryman | Woodie Fryman | Doc Medich | Dale Murray | 279 | 282 | -3 |
| 1976-06-28 | vs CHN | 68 | W 9-2 | 39-29 | 2 | 7,370 | Jim Rooker | Joe Coleman | Jim Rooker | Joe Coleman | | 288 | 284 | 4 |
| 1976-06-29 | vs CHN | 69 | W 10-1 | 40-29 | 2 | 8,774 | John Candelaria | Steve Renko | John Candelaria | Steve Renko | | 298 | 285 | 13 |
| 1976-06-30 | vs CHN | 70 | W 7-5 | 41-29 | 2 | 10,681 | Bruce Kison | Bill Bonham | Bruce Kison | Bill Bonham | Bob Moose | 305 | 290 | 15 |
| 1976-07-02 | vs PHI | 71 | W 10-9 | 42-29 | 2 | 39,328 | Jerry Reuss | Larry Christenson | Ramon Hernandez | Gene Garber | | 315 | 299 | 16 |
| 1976-07-03 | vs PHI | 72 | L 2-3 | 42-30 | 2 | 19,327 | Doc Medich | Tom Underwood | Tug McGraw | Bob Moose | | 317 | 302 | 15 |
| 1976-07-04 | vs PHI | 73 | L 5-10 | 43-31 | 2 | 0 | Larry Demery | Steve Carlton | Steve Carlton | Larry Demery | Ron Reed | 322 | 312 | 10 |
| 1976-07-04 | vs PHI | 74 | W 7-1 | 43-31 | 2 | 32,422 | Bruce Kison | Jim Kaat | Bruce Kison | Jim Kaat | | 329 | 313 | 16 |
| 1976-07-05 | @ ATL | 75 | L 6-8 | 43-32 | 2 | 48,467 | John Candelaria | Phil Niekro | Bruce Dal Canton | Ramon Hernandez | Mike Marshall | 335 | 321 | 14 |
| 1976-07-06 | @ ATL | 76 | L 2-4 | 43-33 | 2 | 12,448 | Jim Rooker | Andy Messersmith | Andy Messersmith | Jim Rooker | Mike Marshall | 337 | 325 | 12 |
| 1976-07-07 | @ ATL | 77 | W 9-7 | 44-33 | 2 | 11,480 | Jerry Reuss | Dick Ruthven | Jerry Reuss | Dick Ruthven | Bob Moose | 346 | 332 | 14 |
| 1976-07-09 | @ CIN | 78 | L 11-12 | 44-35 | 2 | 0 | Bruce Kison | Gary Nolan | Rawly Eastwick | Larry Demery | | 357 | 344 | 13 |
| 1976-07-09 | @ CIN | 79 | L 1-2 | 44-35 | 2 | 53,328 | Doc Medich | Fred Norman | Fred Norman | Doc Medich | | 358 | 346 | 12 |
| 1976-07-10 | @ CIN | 80 | W 7-1 | 45-35 | 2 | 50,756 | John Candelaria | Jack Billingham | John Candelaria | Jack Billingham | | 365 | 347 | 18 |
| 1976-07-11 | @ CIN | 81 | W 8-5 | 46-35 | 2 | 47,153 | Jim Rooker | Don Gullett | Kent Tekulve | Pedro Borbon | Jerry Reuss | 373 | 352 | 21 |
| 1976-07-15 | vs ATL | 82 | W 13-1 | 47-35 | 2 | 10,488 | John Candelaria | Phil Niekro | John Candelaria | Phil Niekro | | 386 | 353 | 33 |
| 1976-07-16 | vs ATL | 83 | W 7-2 | 48-35 | 2 | 11,151 | Jerry Reuss | Andy Messersmith | Jerry Reuss | Andy Messersmith | | 393 | 355 | 38 |
| 1976-07-17 | vs ATL | 84 | L 2-10 | 48-36 | 2 | 14,776 | Bruce Kison | Dick Ruthven | Dick Ruthven | Bruce Kison | | 395 | 365 | 30 |
| 1976-07-18 | vs CIN | 85 | L 8-9 | 48-37 | 2 | 33,697 | Doc Medich | Don Gullett | Jack Billingham | Doc Medich | Rawly Eastwick | 403 | 374 | 29 |
| 1976-07-19 | vs CIN | 86 | L 2-4 | 48-38 | 2 | 26,585 | Jim Rooker | Pat Zachry | Pat Zachry | Jim Rooker | | 405 | 378 | 27 |
| 1976-07-20 | vs HOU | 87 | W 9-5 | 49-39 | 2 | 0 | John Candelaria | Tom Griffin | John Candelaria | Tom Griffin | Kent Tekulve | 414 | 383 | 31 |
| 1976-07-20 | vs HOU | 88 | L 3-4 | 49-39 | 2 | 11,922 | Rick Langford | Bo McLaughlin | Ken Forsch | Dave Giusti | | 417 | 387 | 30 |
| 1976-07-21 | vs HOU | 89 | W 5-1 | 51-39 | 2 | 0 | Jerry Reuss | Larry Dierker | Jerry Reuss | Larry Dierker | | 422 | 388 | 34 |
| 1976-07-21 | vs HOU | 90 | W 4-1 | 51-39 | 2 | 12,209 | Larry Demery | Joaquin Andujar | Larry Demery | Joaquin Andujar | Dave Giusti | 426 | 389 | 37 |
| 1976-07-22 | @ PHI | 91 | L 0-3 | 51-40 | 2 | 43,050 | Bruce Kison | Tom Underwood | Tom Underwood | Bruce Kison | Ron Reed | 426 | 392 | 34 |
| 1976-07-23 | @ PHI | 92 | L 1-11 | 51-41 | 2 | 40,120 | Doc Medich | Jim Lonborg | Jim Lonborg | Doc Medich | | 427 | 403 | 24 |
| 1976-07-24 | @ PHI | 93 | W 8-5 | 52-42 | 2 | 0 | Jim Rooker | Larry Christenson | Jim Rooker | Larry Christenson | Dave Giusti | 435 | 408 | 27 |
| 1976-07-24 | @ PHI | 94 | L 1-7 | 52-42 | 2 | 57,723 | Bob Moose | Steve Carlton | Steve Carlton | Bob Moose | | 436 | 415 | 21 |
| 1976-07-25 | @ PHI | 95 | L 7-13 | 52-43 | 2 | 37,692 | John Candelaria | Jim Kaat | Ron Reed | Dave Giusti | | 443 | 428 | 15 |
| 1976-07-27 | @ SLN | 96 | W 3-1 | 53-43 | 2 | 13,953 | Bruce Kison | Pete Falcone | Bruce Kison | Pete Falcone | | 446 | 429 | 17 |
| 1976-07-28 | @ NYN | 97 | W 1-0 | 54-43 | 2 | 22,215 | Doc Medich | Tom Seaver | Dave Giusti | Ken Sanders | | 447 | 429 | 18 |
| 1976-07-29 | @ NYN | 98 | W 2-1 | 55-43 | 2 | 12,588 | Jim Rooker | Mickey Lolich | Kent Tekulve | Skip Lockwood | | 449 | 430 | 19 |
| 1976-07-30 | vs MON | 99 | W 4-3 | 56-43 | 2 | 12,774 | John Candelaria | Don Carrithers | Kent Tekulve | Joe Kerrigan | | 453 | 433 | 20 |
| 1976-07-31 | vs MON | 100 | L 6-7 | 56-44 | 2 | 10,981 | Jerry Reuss | Don Stanhouse | Dale Murray | Bob Moose | | 459 | 440 | 19 |
| 1976-08-01 | vs MON | 101 | L 0-2 | 56-45 | 2 | 17,150 | Bruce Kison | Steve Rogers | Steve Rogers | Bruce Kison | | 459 | 442 | 17 |
| 1976-08-02 | vs SLN | 102 | L 0-4 | 56-46 | 2 | 7,553 | Doc Medich | Pete Falcone | Pete Falcone | Doc Medich | | 459 | 446 | 13 |
| 1976-08-03 | vs SLN | 103 | W 2-1 | 57-47 | 2 | 0 | Jim Rooker | Eric Rasmussen | Jim Rooker | Bill Greif | | 461 | 447 | 14 |
| 1976-08-03 | vs SLN | 104 | L 2-4 | 57-47 | 2 | 14,781 | Larry Demery | John Curtis | Al Hrabosky | Dave Giusti | Mike Wallace | 463 | 451 | 12 |
| 1976-08-04 | vs SLN | 105 | W 2-1 | 58-47 | 2 | 8,426 | John Candelaria | Bob Forsch | Dave Giusti | Mike Wallace | | 465 | 452 | 13 |
| 1976-08-05 | vs NYN | 106 | L 4-7 | 58-48 | 2 | 7,836 | Jerry Reuss | Jon Matlack | Jon Matlack | Jerry Reuss | Skip Lockwood | 469 | 459 | 10 |
| 1976-08-07 | vs NYN | 107 | W 12-3 | 59-49 | 2 | 0 | Bruce Kison | Tom Seaver | Bruce Kison | Tom Seaver | | 481 | 462 | 19 |
| 1976-08-07 | vs NYN | 108 | L 2-4 | 59-49 | 2 | 12,364 | Doc Medich | Nino Espinosa | Nino Espinosa | Doc Medich | Skip Lockwood | 483 | 466 | 17 |
| 1976-08-08 | vs NYN | 109 | L 4-7 | 59-50 | 2 | 16,538 | Jim Rooker | Mickey Lolich | Mickey Lolich | Jim Rooker | | 487 | 473 | 14 |
| 1976-08-09 | vs LAN | 110 | W 2-0 | 60-50 | 2 | 9,860 | John Candelaria | Doug Rau | John Candelaria | Doug Rau | | 489 | 473 | 16 |
| 1976-08-10 | vs LAN | 111 | L 1-5 | 60-51 | 2 | 13,670 | Jerry Reuss | Don Sutton | Don Sutton | Jerry Reuss | | 490 | 478 | 12 |
| 1976-08-11 | vs LAN | 112 | L 0-2 | 60-52 | 2 | 16,222 | Larry Demery | Rick Rhoden | Rick Rhoden | Larry Demery | | 490 | 480 | 10 |
| 1976-08-13 | @ HOU | 113 | W 8-5 | 61-52 | 2 | 17,876 | Bruce Kison | J.R. Richard | Kent Tekulve | Joe Niekro | | 498 | 485 | 13 |
| 1976-08-14 | @ HOU | 114 | W 5-4 | 62-52 | 2 | 9,721 | John Candelaria | Joaquin Andujar | Dave Giusti | Gene Pentz | | 503 | 489 | 14 |
| 1976-08-15 | @ HOU | 115 | W 8-6 | 64-52 | 2 | 0 | Doc Medich | Dan Larson | Doc Medich | Dan Larson | Kent Tekulve | 511 | 495 | 16 |
| 1976-08-15 | @ HOU | 116 | W 3-0 | 64-52 | 2 | 16,326 | Jerry Reuss | Joe Sambito | Jerry Reuss | Joe Sambito | | 514 | 495 | 19 |
| 1976-08-17 | @ SFN | 117 | L 6-7 | 64-53 | 2 | 9,215 | Larry Demery | John D'Acquisto | Gary Lavelle | Bob Moose | Charlie Williams | 520 | 502 | 18 |
| 1976-08-18 | @ SFN | 118 | W 12-1 | 65-53 | 2 | 3,817 | Jim Rooker | John Montefusco | Jim Rooker | John Montefusco | | 532 | 503 | 29 |
| 1976-08-19 | @ SFN | 119 | W 1-0 | 66-53 | 2 | 2,709 | John Candelaria | Jim Barr | John Candelaria | Jim Barr | | 533 | 503 | 30 |
| 1976-08-20 | @ LAN | 120 | L 1-8 | 66-54 | 2 | 25,107 | Bruce Kison | Doug Rau | Doug Rau | Bruce Kison | Charlie Hough | 534 | 511 | 23 |
| 1976-08-21 | @ LAN | 121 | L 1-5 | 66-55 | 2 | 42,235 | Bob Moose | Don Sutton | Don Sutton | Bob Moose | | 535 | 516 | 19 |
| 1976-08-22 | @ LAN | 122 | W 6-1 | 67-55 | 2 | 24,295 | Larry Demery | Rick Rhoden | Larry Demery | Rick Rhoden | Kent Tekulve | 541 | 517 | 24 |
| 1976-08-23 | @ SDN | 123 | L 4-5 | 67-56 | 2 | 18,396 | Jim Rooker | Rick Sawyer | Jerry Johnson | Jim Rooker | Butch Metzger | 545 | 522 | 23 |
| 1976-08-24 | @ SDN | 124 | L 3-7 | 67-57 | 2 | 11,002 | John Candelaria | Brent Strom | Brent Strom | John Candelaria | | 548 | 529 | 19 |
| 1976-08-25 | @ SDN | 125 | W 3-0 | 68-57 | 2 | 10,963 | Bruce Kison | Dave Freisleben | Bruce Kison | Dave Freisleben | | 551 | 529 | 22 |
| 1976-08-27 | vs SFN | 126 | W 5-2 | 69-57 | 2 | 12,580 | Larry Demery | John Montefusco | Larry Demery | John Montefusco | | 556 | 531 | 25 |
| 1976-08-28 | vs SFN | 127 | W 7-1 | 70-57 | 2 | 11,043 | Jim Rooker | John D'Acquisto | Jim Rooker | John D'Acquisto | | 563 | 532 | 31 |
| 1976-08-29 | vs SFN | 128 | W 3-2 | 71-57 | 2 | 12,972 | John Candelaria | Jim Barr | John Candelaria | Randy Moffitt | | 566 | 534 | 32 |
| 1976-08-31 | vs SDN | 129 | W 3-0 | 72-57 | 2 | 9,674 | Jerry Reuss | Randy Jones | Jerry Reuss | Randy Jones | | 569 | 534 | 35 |
| 1976-09-01 | vs SDN | 130 | W 4-1 | 73-57 | 2 | 5,381 | Bruce Kison | Brent Strom | Bruce Kison | Brent Strom | Kent Tekulve | 573 | 535 | 38 |
| 1976-09-02 | vs SDN | 131 | W 5-0 | 74-57 | 2 | 5,545 | Larry Demery | Dave Freisleben | Larry Demery | Dave Freisleben | | 578 | 535 | 43 |
| 1976-09-03 | @ MON | 132 | W 9-7 | 76-57 | 2 | 0 | Jim Rooker | Don Stanhouse | Jim Rooker | Don Stanhouse | Kent Tekulve | 587 | 542 | 45 |
| 1976-09-03 | @ MON | 133 | W 7-2 | 76-57 | 2 | 6,342 | John Candelaria | Don Carrithers | John Candelaria | Don Carrithers | | 594 | 544 | 50 |
| 1976-09-04 | @ MON | 134 | W 5-3 | 77-57 | 2 | 3,290 | Doc Medich | Dennis Blair | Dave Giusti | Dale Murray | Kent Tekulve | 599 | 547 | 52 |
| 1976-09-05 | @ MON | 135 | L 0-1 | 77-58 | 2 | 6,180 | Jerry Reuss | Woodie Fryman | Woodie Fryman | Jerry Reuss | | 599 | 548 | 51 |
| 1976-09-06 | vs PHI | 136 | W 6-2 | 79-58 | 2 | 0 | Bruce Kison | Jim Kaat | Bruce Kison | Jim Kaat | | 605 | 550 | 55 |
| 1976-09-06 | vs PHI | 137 | W 5-1 | 79-58 | 2 | 41,703 | Larry Demery | Tom Underwood | Larry Demery | Tom Underwood | | 610 | 551 | 59 |
| 1976-09-08 | vs PHI | 138 | W 6-1 | 80-58 | 2 | 30,976 | Jim Rooker | Steve Carlton | Jim Rooker | Steve Carlton | | 616 | 552 | 64 |
| 1976-09-10 | vs MON | 139 | L 2-4 | 80-59 | 2 | 12,032 | John Candelaria | Woodie Fryman | Woodie Fryman | John Candelaria | | 618 | 556 | 62 |
| 1976-09-11 | vs MON | 140 | W 4-3 | 81-59 | 2 | 7,509 | Jerry Reuss | Steve Rogers | Jerry Reuss | Steve Rogers | Kent Tekulve | 622 | 559 | 63 |
| 1976-09-12 | vs MON | 141 | W 6-1 | 82-59 | 2 | 12,765 | Bruce Kison | Don Stanhouse | Bruce Kison | Don Stanhouse | Kent Tekulve | 628 | 560 | 68 |
| 1976-09-13 | vs NYN | 142 | L 0-5 | 82-60 | 2 | 7,892 | Larry Demery | Tom Seaver | Tom Seaver | Larry Demery | | 628 | 565 | 63 |
| 1976-09-14 | vs NYN | 143 | L 3-4 | 82-61 | 2 | 7,867 | Jim Rooker | Craig Swan | Skip Lockwood | Jim Rooker | | 631 | 569 | 62 |
| 1976-09-15 | @ PHI | 144 | W 7-2 | 83-61 | 2 | 45,010 | John Candelaria | Jim Kaat | John Candelaria | Jim Kaat | | 638 | 571 | 67 |
| 1976-09-16 | @ PHI | 145 | W 7-6 | 84-61 | 2 | 35,806 | Jerry Reuss | Tom Underwood | Kent Tekulve | Ron Reed | | 645 | 577 | 68 |
| 1976-09-17 | @ NYN | 146 | W 4-1 | 85-61 | 2 | 14,304 | Doc Medich | Jon Matlack | Doc Medich | Jon Matlack | Dave Giusti | 649 | 578 | 71 |
| 1976-09-18 | @ NYN | 147 | L 2-6 | 85-62 | 2 | 15,879 | Larry Demery | Tom Seaver | Tom Seaver | Larry Demery | | 651 | 584 | 67 |
| 1976-09-19 | @ NYN | 148 | L 6-7 | 85-63 | 2 | 18,652 | Jim Rooker | Craig Swan | Nino Espinosa | Dave Giusti | Skip Lockwood | 657 | 591 | 66 |
| 1976-09-20 | @ NYN | 149 | L 4-5 | 85-64 | 2 | 5,922 | John Candelaria | Mickey Lolich | Bob Apodaca | Kent Tekulve | | 661 | 596 | 65 |
| 1976-09-21 | @ CHN | 150 | W 4-3 | 86-65 | 2 | 0 | Bruce Kison | Steve Renko | Bruce Kison | Steve Renko | Jim Rooker | 665 | 599 | 66 |
| 1976-09-21 | @ CHN | 151 | L 1-2 | 86-65 | 2 | 5,017 | Jerry Reuss | Steve Stone | Paul Reuschel | Bob Moose | | 666 | 601 | 65 |
| 1976-09-22 | @ CHN | 152 | L 3-4 | 86-66 | 2 | 3,375 | Doc Medich | Bill Bonham | Joe Coleman | Kent Tekulve | | 669 | 605 | 64 |
| 1976-09-23 | @ CHN | 153 | W 5-4 | 87-66 | 2 | 2,132 | Larry Demery | Rick Reuschel | Dave Giusti | Darold Knowles | Bruce Kison | 674 | 609 | 65 |
| 1976-09-24 | @ SLN | 154 | L 6-10 | 88-67 | 2 | 0 | John Candelaria | Bob Forsch | Bob Forsch | John Candelaria | | 680 | 619 | 61 |
| 1976-09-24 | @ SLN | 155 | W 11-1 | 88-67 | 2 | 10,368 | Jim Rooker | John Curtis | Jim Rooker | John Curtis | | 691 | 620 | 71 |
| 1976-09-25 | @ SLN | 156 | L 0-3 | 88-68 | 2 | 7,858 | Jerry Reuss | Lynn McGlothen | Lynn McGlothen | Jerry Reuss | | 691 | 623 | 68 |
| 1976-09-26 | @ SLN | 157 | L 2-5 | 88-69 | 2 | 10,456 | Bruce Kison | John Denny | John Denny | Bruce Kison | Al Hrabosky | 693 | 628 | 65 |
| 1976-09-28 | vs CHN | 158 | W 5-1 | 89-69 | 2 | 2,880 | Doc Medich | Rick Reuschel | Doc Medich | Rick Reuschel | Jerry Reuss | 698 | 629 | 69 |
| 1976-09-29 | vs CHN | 159 | L 0-1 | 89-70 | 2 | 2,880 | Larry Demery | Steve Renko | Steve Renko | Larry Demery | | 698 | 630 | 68 |
| 1976-10-02 | vs SLN | 160 | W 8-0 | 90-70 | 2 | 4,250 | John Candelaria | Lynn McGlothen | John Candelaria | Lynn McGlothen | | 706 | 630 | 76 |
| 1976-10-03 | vs SLN | 161 | W 1-0 | 92-70 | 2 | 0 | Jim Rooker | John Denny | Jim Rooker | John Denny | | 707 | 630 | 77 |
| 1976-10-03 | vs SLN | 162 | W 1-0 | 92-70 | 2 | 24,228 | Jerry Reuss | Pete Falcone | Jerry Reuss | Pete Falcone | | 708 | 630 | 78 |