| 1976-04-10 | vs PIT | 1 | L 4-5 | 0-1 | 6 | 42,147 | Jim Kaat | Doc Medich | Larry Demery | Tug McGraw | | 4 | 5 | -1 |
| 1976-04-11 | vs PIT | 2 | L 3-8 | 0-2 | 6 | 18,373 | Steve Carlton | Bruce Kison | Bruce Kison | Steve Carlton | Bob Moose | 7 | 13 | -6 |
| 1976-04-14 | @ MON | 3 | W 8-2 | 1-2 | 4 | 21,199 | Jim Lonborg | Steve Rogers | Jim Lonborg | Steve Rogers | | 15 | 15 | 0 |
| 1976-04-15 | @ MON | 4 | L 5-8 | 1-3 | 5 | 6,375 | Jim Kaat | Woodie Fryman | Woodie Fryman | Jim Kaat | Wayne Granger | 20 | 23 | -3 |
| 1976-04-17 | @ CHN | 5 | W 18-16 | 2-3 | 4 | 28,287 | Steve Carlton | Rick Reuschel | Tug McGraw | Darold Knowles | Jim Lonborg | 38 | 39 | -1 |
| 1976-04-18 | @ CHN | 6 | W 8-5 | 3-3 | 3 | 13,326 | Larry Christenson | Ray Burris | Larry Christenson | Ray Burris | Gene Garber | 46 | 44 | 2 |
| 1976-04-20 | @ PIT | 7 | W 5-1 | 4-3 | 2 | 8,800 | Jim Kaat | John Candelaria | Jim Kaat | John Candelaria | | 51 | 45 | 6 |
| 1976-04-21 | @ PIT | 8 | W 3-0 | 5-3 | 2 | 9,175 | Tom Underwood | Doc Medich | Tom Underwood | Doc Medich | Tug McGraw | 54 | 45 | 9 |
| 1976-04-23 | vs ATL | 9 | L 5-6 | 5-4 | 2 | 29,398 | Jim Lonborg | Carl Morton | Bruce Dal Canton | Tug McGraw | Elias Sosa | 59 | 51 | 8 |
| 1976-04-24 | vs ATL | 10 | W 10-5 | 6-4 | 1 | 25,477 | Steve Carlton | Andy Messersmith | Ron Reed | Elias Sosa | | 69 | 56 | 13 |
| 1976-04-25 | vs ATL | 11 | L 2-3 | 6-5 | 2 | 10,565 | Larry Christenson | Phil Niekro | Phil Niekro | Larry Christenson | Elias Sosa | 71 | 59 | 12 |
| 1976-04-26 | vs CIN | 12 | W 10-9 | 7-5 | 1 | 16,565 | Jim Kaat | Fred Norman | Tug McGraw | Rawly Eastwick | | 81 | 68 | 13 |
| 1976-04-27 | vs CIN | 13 | L 3-7 | 7-6 | 2 | 17,818 | Tom Underwood | Jack Billingham | Jack Billingham | Tom Underwood | | 84 | 75 | 9 |
| 1976-04-28 | vs CIN | 14 | W 7-6 | 8-6 | 2 | 20,215 | Jim Lonborg | Pat Darcy | Jim Lonborg | Pat Darcy | Tug McGraw | 91 | 81 | 10 |
| 1976-05-01 | @ ATL | 15 | W 3-0 | 10-6 | 2 | 0 | Larry Christenson | Dick Ruthven | Larry Christenson | Dick Ruthven | Tug McGraw | 94 | 81 | 13 |
| 1976-05-01 | @ ATL | 16 | W 4-2 | 10-6 | 2 | 24,189 | Steve Carlton | Carl Morton | Steve Carlton | Carl Morton | | 98 | 83 | 15 |
| 1976-05-02 | @ ATL | 17 | W 8-2 | 11-6 | 1 | 20,479 | Jim Kaat | Andy Messersmith | Jim Kaat | Andy Messersmith | Gene Garber | 106 | 85 | 21 |
| 1976-05-04 | vs HOU | 18 | W 5-0 | 12-6 | 1 | 10,655 | Jim Lonborg | Larry Dierker | Jim Lonborg | Larry Dierker | | 111 | 85 | 26 |
| 1976-05-05 | vs HOU | 19 | W 6-3 | 13-6 | 1 | 17,944 | Steve Carlton | Joe Niekro | Ron Reed | Joe Niekro | Gene Garber | 117 | 88 | 29 |
| 1976-05-07 | vs LAN | 20 | L 8-10 | 13-7 | 2 | 28,862 | Larry Christenson | Rick Rhoden | Charlie Hough | Ron Reed | Mike Marshall | 125 | 98 | 27 |
| 1976-05-08 | vs LAN | 21 | W 6-4 | 14-7 | 2 | 34,060 | Jim Kaat | Tommy John | Gene Garber | Tommy John | | 131 | 102 | 29 |
| 1976-05-09 | vs LAN | 22 | W 10-3 | 15-7 | 1 | 24,143 | Jim Lonborg | Doug Rau | Jim Lonborg | Doug Rau | | 141 | 105 | 36 |
| 1976-05-11 | vs SDN | 23 | W 9-1 | 16-7 | 1 | 11,576 | Steve Carlton | Dan Spillner | Steve Carlton | Dan Spillner | | 150 | 106 | 44 |
| 1976-05-12 | vs SDN | 24 | L 0-4 | 16-8 | 1 | 20,043 | Jim Kaat | Randy Jones | Randy Jones | Jim Kaat | | 150 | 110 | 40 |
| 1976-05-14 | @ HOU | 25 | W 5-1 | 17-8 | 1 | 14,264 | Larry Christenson | Mike Cosgrove | Larry Christenson | Mike Cosgrove | | 155 | 111 | 44 |
| 1976-05-15 | @ HOU | 26 | W 2-1 | 17-9 | 1 | 20,749 | Jim Lonborg | Larry Dierker | Jim Lonborg | Larry Dierker | | 157 | 112 | 45 |
| 1976-05-16 | @ HOU | 27 | W 12-2 | 18-9 | 1 | 11,553 | Steve Carlton | Tom Griffin | Steve Carlton | Tom Griffin | | 169 | 114 | 55 |
| 1976-05-19 | @ NYN | 28 | W 2-1 | 19-9 | 1 | 12,836 | Larry Christenson | Mickey Lolich | Larry Christenson | Mickey Lolich | Tom Underwood | 171 | 115 | 56 |
| 1976-05-20 | @ NYN | 29 | W 5-3 | 20-9 | 1 | 16,914 | Jim Lonborg | Tom Seaver | Jim Lonborg | Tom Seaver | Tug McGraw | 176 | 118 | 58 |
| 1976-05-21 | vs SLN | 30 | W 2-1 | 21-9 | 1 | 32,074 | Steve Carlton | Pete Falcone | Steve Carlton | Pete Falcone | | 178 | 119 | 59 |
| 1976-05-22 | vs SLN | 31 | L 6-7 | 21-10 | 1 | 39,098 | Jim Kaat | John Curtis | Al Hrabosky | Tug McGraw | | 184 | 126 | 58 |
| 1976-05-23 | vs SLN | 32 | W 3-2 | 22-10 | 1 | 37,537 | Tom Underwood | Bob Forsch | Tug McGraw | Al Hrabosky | | 187 | 128 | 59 |
| 1976-05-24 | vs NYN | 33 | W 7-1 | 23-10 | 1 | 21,899 | Larry Christenson | Mickey Lolich | Larry Christenson | Mickey Lolich | | 194 | 129 | 65 |
| 1976-05-25 | vs NYN | 34 | W 8-4 | 24-10 | 1 | 32,772 | Jim Lonborg | Tom Seaver | Jim Lonborg | Tom Seaver | | 202 | 133 | 69 |
| 1976-05-26 | vs NYN | 35 | W 5-0 | 25-10 | 1 | 28,306 | Steve Carlton | Jon Matlack | Steve Carlton | Jon Matlack | | 207 | 133 | 74 |
| 1976-05-27 | vs NYN | 36 | L 2-5 | 25-11 | 1 | 29,525 | Jim Kaat | Jerry Koosman | Jerry Koosman | Gene Garber | Skip Lockwood | 209 | 138 | 71 |
| 1976-05-28 | vs MON | 37 | W 10-3 | 26-11 | 1 | 23,011 | Tom Underwood | Don Stanhouse | Ron Reed | Don Stanhouse | | 219 | 141 | 78 |
| 1976-05-29 | vs MON | 38 | W 6-1 | 27-11 | 1 | 18,063 | Larry Christenson | Don Carrithers | Larry Christenson | Don Carrithers | Gene Garber | 225 | 142 | 83 |
| 1976-05-30 | vs MON | 39 | W 7-1 | 28-11 | 1 | 27,090 | Jim Lonborg | Clay Kirby | Jim Lonborg | Clay Kirby | | 232 | 143 | 89 |
| 1976-05-31 | vs CHN | 40 | L 5-7 | 29-12 | 1 | 0 | Steve Carlton | Rick Reuschel | Rick Reuschel | Steve Carlton | Bruce Sutter | 237 | 150 | 87 |
| 1976-05-31 | vs CHN | 41 | W 4-1 | 29-12 | 1 | 51,211 | Jim Kaat | Mike Garman | Jim Kaat | Mike Garman | | 241 | 151 | 90 |
| 1976-06-01 | vs CHN | 42 | W 6-1 | 30-12 | 1 | 26,846 | Ron Reed | Steve Renko | Ron Reed | Steve Renko | | 247 | 152 | 95 |
| 1976-06-02 | @ SLN | 43 | W 4-1 | 31-12 | 1 | 16,850 | Tom Underwood | John Curtis | Tom Underwood | John Curtis | | 251 | 153 | 98 |
| 1976-06-03 | @ SLN | 44 | L 1-7 | 31-13 | 1 | 15,832 | Larry Christenson | Bob Forsch | Bob Forsch | Larry Christenson | | 252 | 160 | 92 |
| 1976-06-04 | @ SFN | 45 | L 1-5 | 31-14 | 1 | 7,374 | Jim Lonborg | Jim Barr | Jim Barr | Jim Lonborg | | 253 | 165 | 88 |
| 1976-06-05 | @ SFN | 46 | L 2-4 | 31-15 | 1 | 9,439 | Steve Carlton | Ed Halicki | Ed Halicki | Steve Carlton | Randy Moffitt | 255 | 169 | 86 |
| 1976-06-06 | @ SFN | 47 | W 9-3 | 32-15 | 1 | 30,218 | Jim Kaat | John Montefusco | Jim Kaat | John Montefusco | | 264 | 172 | 92 |
| 1976-06-07 | @ LAN | 48 | W 8-6 | 33-15 | 1 | 30,627 | Ron Reed | Rick Rhoden | Ron Reed | Charlie Hough | Gene Garber | 272 | 178 | 94 |
| 1976-06-08 | @ LAN | 49 | W 14-2 | 34-15 | 1 | 27,950 | Larry Christenson | Tommy John | Larry Christenson | Tommy John | | 286 | 180 | 106 |
| 1976-06-09 | @ LAN | 50 | L 2-3 | 34-16 | 1 | 27,794 | Jim Lonborg | Burt Hooton | Burt Hooton | Jim Lonborg | Charlie Hough | 288 | 183 | 105 |
| 1976-06-10 | @ LAN | 51 | W 10-6 | 35-16 | 1 | 27,052 | Steve Carlton | Doug Rau | Tug McGraw | Stan Wall | Ron Schueler | 298 | 189 | 109 |
| 1976-06-11 | @ SDN | 52 | W 4-2 | 36-16 | 1 | 15,754 | Jim Kaat | Alan Foster | Jim Kaat | Alan Foster | Tom Underwood | 302 | 191 | 111 |
| 1976-06-12 | @ SDN | 53 | W 3-2 | 37-16 | 1 | 24,515 | Ron Reed | Dave Freisleben | Tom Underwood | Ken Reynolds | Ron Schueler | 305 | 193 | 112 |
| 1976-06-13 | @ SDN | 54 | L 0-5 | 37-18 | 1 | 0 | Jim Lonborg | Randy Jones | Randy Jones | Jim Lonborg | | 305 | 198 | 107 |
| 1976-06-13 | @ SDN | 55 | L 3-4 | 37-18 | 1 | 43,473 | Larry Christenson | Dan Spillner | Rich Folkers | Larry Christenson | Butch Metzger | 308 | 202 | 106 |
| 1976-06-15 | vs SFN | 56 | W 10-2 | 38-18 | 1 | 28,564 | Steve Carlton | Ed Halicki | Steve Carlton | Ed Halicki | | 318 | 204 | 114 |
| 1976-06-16 | vs SFN | 57 | W 6-1 | 39-18 | 1 | 28,966 | Jim Kaat | John Montefusco | Jim Kaat | John Montefusco | | 324 | 205 | 119 |
| 1976-06-17 | vs SFN | 58 | W 3-2 | 40-18 | 1 | 27,800 | Larry Christenson | John D'Acquisto | Gene Garber | Gary Lavelle | | 327 | 207 | 120 |
| 1976-06-18 | vs CIN | 59 | W 6-5 | 41-18 | 1 | 50,635 | Jim Lonborg | Jack Billingham | Jim Lonborg | Jack Billingham | Gene Garber | 333 | 212 | 121 |
| 1976-06-19 | vs CIN | 60 | L 3-4 | 41-19 | 1 | 36,808 | Steve Carlton | Gary Nolan | Gary Nolan | Ron Reed | Rawly Eastwick | 336 | 216 | 120 |
| 1976-06-20 | vs CIN | 61 | W 6-1 | 42-19 | 1 | 38,669 | Jim Kaat | Don Gullett | Jim Kaat | Don Gullett | | 342 | 217 | 125 |
| 1976-06-21 | vs MON | 62 | W 8-3 | 43-19 | 1 | 26,148 | Tom Underwood | Dan Warthen | Tom Underwood | Dan Warthen | | 350 | 220 | 130 |
| 1976-06-22 | vs MON | 63 | L 3-8 | 43-20 | 1 | 32,138 | Jim Lonborg | Clay Kirby | Clay Kirby | Jim Lonborg | Dale Murray | 353 | 228 | 125 |
| 1976-06-23 | @ CIN | 64 | W 4-2 | 44-20 | 1 | 35,266 | Steve Carlton | Santo Alcala | Ron Reed | Pedro Borbon | Gene Garber | 357 | 230 | 127 |
| 1976-06-24 | @ CIN | 65 | W 5-4 | 45-20 | 1 | 34,053 | Jim Kaat | Gary Nolan | Jim Kaat | Gary Nolan | Tug McGraw | 362 | 234 | 128 |
| 1976-06-25 | vs SLN | 66 | W 12-4 | 46-20 | 1 | 38,474 | Larry Christenson | John Curtis | Larry Christenson | John Curtis | | 374 | 238 | 136 |
| 1976-06-26 | vs SLN | 67 | L 2-3 | 46-21 | 1 | 41,052 | Tom Underwood | Bob Forsch | Al Hrabosky | Tug McGraw | | 376 | 241 | 135 |
| 1976-06-27 | vs SLN | 68 | W 6-2 | 47-21 | 1 | 31,489 | Jim Lonborg | Lynn McGlothen | Jim Lonborg | Lynn McGlothen | Ron Reed | 382 | 243 | 139 |
| 1976-06-28 | @ MON | 69 | W 6-2 | 48-21 | 1 | 14,177 | Steve Carlton | Steve Rogers | Steve Carlton | Steve Rogers | | 388 | 245 | 143 |
| 1976-06-29 | @ MON | 70 | W 2-1 | 49-21 | 1 | 10,939 | Jim Kaat | Don Stanhouse | Gene Garber | Dale Murray | Ron Reed | 390 | 246 | 144 |
| 1976-07-02 | @ PIT | 71 | L 9-10 | 49-22 | 1 | 39,328 | Larry Christenson | Jerry Reuss | Ramon Hernandez | Gene Garber | | 399 | 256 | 143 |
| 1976-07-03 | @ PIT | 72 | W 3-2 | 50-22 | 1 | 19,327 | Tom Underwood | Doc Medich | Tug McGraw | Bob Moose | | 402 | 258 | 144 |
| 1976-07-04 | @ PIT | 73 | W 10-5 | 51-23 | 1 | 0 | Steve Carlton | Larry Demery | Steve Carlton | Larry Demery | Ron Reed | 412 | 263 | 149 |
| 1976-07-04 | @ PIT | 74 | L 1-7 | 51-23 | 1 | 32,422 | Jim Kaat | Bruce Kison | Bruce Kison | Jim Kaat | | 413 | 270 | 143 |
| 1976-07-05 | vs LAN | 75 | L 0-6 | 51-24 | 1 | 60,943 | Jim Lonborg | Burt Hooton | Burt Hooton | Jim Lonborg | | 413 | 276 | 137 |
| 1976-07-06 | vs LAN | 76 | L 1-5 | 51-25 | 1 | 34,126 | Larry Christenson | Doug Rau | Doug Rau | Larry Christenson | | 414 | 281 | 133 |
| 1976-07-07 | vs LAN | 77 | L 5-6 | 51-26 | 1 | 35,013 | Jim Kaat | Don Sutton | Don Sutton | Ron Reed | Charlie Hough | 419 | 287 | 132 |
| 1976-07-09 | vs SDN | 78 | W 4-3 | 52-26 | 1 | 35,217 | Tom Underwood | Brent Strom | Tom Underwood | Brent Strom | Ron Reed | 423 | 290 | 133 |
| 1976-07-10 | vs SDN | 79 | W 5-0 | 54-26 | 1 | 0 | Steve Carlton | Alan Foster | Steve Carlton | Alan Foster | | 428 | 290 | 138 |
| 1976-07-10 | vs SDN | 80 | W 4-2 | 54-26 | 1 | 47,101 | Jim Lonborg | Dan Spillner | Jim Lonborg | Dan Spillner | Ron Reed | 432 | 292 | 140 |
| 1976-07-11 | vs SDN | 81 | W 3-0 | 55-26 | 1 | 46,807 | Jim Kaat | Dave Freisleben | Jim Kaat | Dave Freisleben | | 435 | 292 | 143 |
| 1976-07-15 | @ SFN | 82 | W 5-3 | 56-26 | 1 | 5,759 | Steve Carlton | Jim Barr | Steve Carlton | Mike Caldwell | | 440 | 295 | 145 |
| 1976-07-16 | @ SFN | 83 | L 0-1 | 56-27 | 1 | 7,330 | Jim Kaat | Ed Halicki | Ed Halicki | Jim Kaat | | 440 | 296 | 144 |
| 1976-07-17 | @ SFN | 84 | L 1-4 | 56-28 | 1 | 8,909 | Tom Underwood | John Montefusco | John Montefusco | Tom Underwood | | 441 | 300 | 141 |
| 1976-07-18 | @ LAN | 85 | W 2-1 | 57-28 | 1 | 52,214 | Jim Lonborg | Tommy John | Ron Reed | Charlie Hough | | 443 | 301 | 142 |
| 1976-07-19 | @ LAN | 86 | W 5-3 | 58-28 | 1 | 37,109 | Larry Christenson | Burt Hooton | Gene Garber | Burt Hooton | Ron Reed | 448 | 304 | 144 |
| 1976-07-20 | @ SDN | 87 | L 0-3 | 58-29 | 1 | 20,499 | Steve Carlton | Randy Jones | Randy Jones | Steve Carlton | | 448 | 307 | 141 |
| 1976-07-21 | @ SDN | 88 | W 5-1 | 59-29 | 1 | 14,996 | Jim Kaat | Dave Freisleben | Jim Kaat | Dave Freisleben | Gene Garber | 453 | 308 | 145 |
| 1976-07-22 | vs PIT | 89 | W 3-0 | 60-29 | 1 | 43,050 | Tom Underwood | Bruce Kison | Tom Underwood | Bruce Kison | Ron Reed | 456 | 308 | 148 |
| 1976-07-23 | vs PIT | 90 | W 11-1 | 61-29 | 1 | 40,120 | Jim Lonborg | Doc Medich | Jim Lonborg | Doc Medich | | 467 | 309 | 158 |
| 1976-07-24 | vs PIT | 91 | L 5-8 | 62-30 | 1 | 0 | Larry Christenson | Jim Rooker | Jim Rooker | Larry Christenson | Dave Giusti | 472 | 317 | 155 |
| 1976-07-24 | vs PIT | 92 | W 7-1 | 62-30 | 1 | 57,723 | Steve Carlton | Bob Moose | Steve Carlton | Bob Moose | | 479 | 318 | 161 |
| 1976-07-25 | vs PIT | 93 | W 13-7 | 63-30 | 1 | 37,692 | Jim Kaat | John Candelaria | Ron Reed | Dave Giusti | | 492 | 325 | 167 |
| 1976-07-26 | vs NYN | 94 | W 4-1 | 64-30 | 1 | 35,023 | Larry Christenson | Jon Matlack | Larry Christenson | Jon Matlack | Tug McGraw | 496 | 326 | 170 |
| 1976-07-27 | vs NYN | 95 | L 1-4 | 64-31 | 1 | 35,376 | Tom Underwood | Craig Swan | Bob Myrick | Tom Underwood | Skip Lockwood | 497 | 330 | 167 |
| 1976-07-28 | vs CHN | 96 | L 2-5 | 64-32 | 1 | 35,043 | Jim Lonborg | Bill Bonham | Bruce Sutter | Ron Reed | | 499 | 335 | 164 |
| 1976-07-29 | vs CHN | 97 | W 3-2 | 65-32 | 1 | 35,154 | Steve Carlton | Rick Reuschel | Gene Garber | Darold Knowles | | 502 | 337 | 165 |
| 1976-07-30 | @ NYN | 98 | L 2-3 | 65-33 | 1 | 26,548 | Jim Kaat | Jerry Koosman | Jerry Koosman | Jim Kaat | | 504 | 340 | 164 |
| 1976-07-31 | @ NYN | 99 | W 2-1 | 66-33 | 1 | 22,792 | Larry Christenson | Jon Matlack | Larry Christenson | Jon Matlack | Tug McGraw | 506 | 341 | 165 |
| 1976-08-01 | @ NYN | 100 | W 7-6 | 68-33 | 1 | 0 | Tom Underwood | Bob Apodaca | Gene Garber | Skip Lockwood | | 513 | 347 | 166 |
| 1976-08-01 | @ NYN | 101 | W 2-0 | 68-33 | 1 | 34,413 | Wayne Twitchell | Nino Espinosa | Wayne Twitchell | Nino Espinosa | Ron Schueler | 515 | 347 | 168 |
| 1976-08-02 | @ CHN | 102 | L 2-4 | 68-34 | 1 | 9,525 | Jim Lonborg | Bill Bonham | Bill Bonham | Jim Lonborg | Joe Coleman | 517 | 351 | 166 |
| 1976-08-03 | @ CHN | 103 | L 0-4 | 69-35 | 1 | 0 | Jim Kaat | Rick Reuschel | Rick Reuschel | Jim Kaat | | 517 | 355 | 162 |
| 1976-08-03 | @ CHN | 104 | W 8-5 | 69-35 | 1 | 27,636 | Steve Carlton | Steve Stone | Steve Carlton | Steve Stone | Ron Reed | 525 | 360 | 165 |
| 1976-08-04 | @ CHN | 105 | W 7-5 | 70-35 | 1 | 16,070 | Larry Christenson | Steve Renko | Gene Garber | Joe Coleman | | 532 | 365 | 167 |
| 1976-08-05 | @ SLN | 106 | W 5-2 | 71-35 | 1 | 15,569 | Tom Underwood | Lynn McGlothen | Wayne Twitchell | Lynn McGlothen | | 537 | 367 | 170 |
| 1976-08-06 | @ SLN | 107 | L 2-6 | 71-36 | 1 | 25,339 | Jim Lonborg | John Denny | John Denny | Jim Lonborg | Al Hrabosky | 539 | 373 | 166 |
| 1976-08-07 | @ SLN | 108 | L 1-4 | 71-37 | 1 | 32,105 | Jim Kaat | Pete Falcone | Pete Falcone | Jim Kaat | Al Hrabosky | 540 | 377 | 163 |
| 1976-08-08 | @ SLN | 109 | W 3-2 | 72-37 | 1 | 27,448 | Steve Carlton | Eric Rasmussen | Steve Carlton | Bill Greif | Ron Reed | 543 | 379 | 164 |
| 1976-08-10 | vs ATL | 110 | L 1-2 | 72-38 | 1 | 30,323 | Larry Christenson | Phil Niekro | Phil Niekro | Larry Christenson | Adrian Devine | 544 | 381 | 163 |
| 1976-08-11 | vs ATL | 111 | W 4-1 | 73-38 | 1 | 30,247 | Tom Underwood | Carl Morton | Tom Underwood | Carl Morton | Ron Reed | 548 | 382 | 166 |
| 1976-08-12 | vs ATL | 112 | L 3-4 | 73-39 | 1 | 30,415 | Jim Lonborg | Frank LaCorte | Frank LaCorte | Jim Lonborg | Adrian Devine | 551 | 386 | 165 |
| 1976-08-13 | vs SFN | 113 | L 0-3 | 73-40 | 1 | 32,642 | Jim Kaat | John Montefusco | John Montefusco | Jim Kaat | | 551 | 389 | 162 |
| 1976-08-14 | vs SFN | 114 | W 13-2 | 74-40 | 1 | 38,368 | Steve Carlton | Jim Barr | Steve Carlton | Jim Barr | | 564 | 391 | 173 |
| 1976-08-15 | vs SFN | 115 | L 5-9 | 74-41 | 1 | 28,316 | Larry Christenson | Rob Dressler | Randy Moffitt | Gene Garber | | 569 | 400 | 169 |
| 1976-08-17 | vs MON | 116 | W 11-3 | 75-41 | 1 | 27,188 | Tom Underwood | Steve Rogers | Tom Underwood | Steve Rogers | | 580 | 403 | 177 |
| 1976-08-18 | vs MON | 117 | W 5-4 | 76-41 | 1 | 28,483 | Jim Lonborg | Don Stanhouse | Jim Lonborg | Don Stanhouse | Ron Reed | 585 | 407 | 178 |
| 1976-08-19 | vs HOU | 118 | W 7-1 | 77-41 | 1 | 35,605 | Steve Carlton | Joaquin Andujar | Steve Carlton | Joaquin Andujar | | 592 | 408 | 184 |
| 1976-08-20 | vs HOU | 119 | L 3-8 | 77-42 | 1 | 36,049 | Wayne Twitchell | Dan Larson | Dan Larson | Wayne Twitchell | | 595 | 416 | 179 |
| 1976-08-21 | vs HOU | 120 | W 7-4 | 78-42 | 1 | 37,756 | Jim Kaat | J.R. Richard | Jim Kaat | J.R. Richard | Ron Reed | 602 | 420 | 182 |
| 1976-08-22 | vs HOU | 121 | W 5-1 | 79-42 | 1 | 43,513 | Tom Underwood | Larry Dierker | Tom Underwood | Larry Dierker | | 607 | 421 | 186 |
| 1976-08-23 | @ ATL | 122 | W 4-2 | 80-42 | 1 | 11,600 | Jim Lonborg | Dick Ruthven | Jim Lonborg | Dick Ruthven | Tug McGraw | 611 | 423 | 188 |
| 1976-08-24 | @ ATL | 123 | W 14-3 | 81-42 | 1 | 25,156 | Steve Carlton | Andy Messersmith | Steve Carlton | Andy Messersmith | | 625 | 426 | 199 |
| 1976-08-25 | @ ATL | 124 | L 1-5 | 81-43 | 1 | 7,514 | Larry Christenson | Phil Niekro | Phil Niekro | Larry Christenson | | 626 | 431 | 195 |
| 1976-08-26 | @ CIN | 125 | W 5-4 | 82-43 | 1 | 38,094 | Jim Kaat | Gary Nolan | Tug McGraw | Rawly Eastwick | | 631 | 435 | 196 |
| 1976-08-27 | @ CIN | 126 | L 1-4 | 82-44 | 1 | 49,821 | Tom Underwood | Fred Norman | Fred Norman | Tom Underwood | Pedro Borbon | 632 | 439 | 193 |
| 1976-08-28 | @ CIN | 127 | L 7-8 | 82-45 | 1 | 51,091 | Jim Lonborg | Jack Billingham | Rawly Eastwick | Tug McGraw | | 639 | 447 | 192 |
| 1976-08-29 | @ CIN | 128 | L 5-6 | 82-46 | 1 | 51,376 | Steve Carlton | Pat Zachry | Santo Alcala | Jim Kaat | | 644 | 453 | 191 |
| 1976-08-30 | @ HOU | 129 | L 1-3 | 82-47 | 1 | 5,437 | Larry Christenson | Dan Larson | Dan Larson | Larry Christenson | | 645 | 456 | 189 |
| 1976-08-31 | @ HOU | 130 | L 2-3 | 82-48 | 1 | 6,881 | Tom Underwood | J.R. Richard | J.R. Richard | Tug McGraw | | 647 | 459 | 188 |
| 1976-09-01 | @ HOU | 131 | L 0-1 | 82-49 | 1 | 6,395 | Jim Kaat | Bo McLaughlin | Bo McLaughlin | Jim Kaat | | 647 | 460 | 187 |
| 1976-09-03 | @ NYN | 132 | L 0-1 | 82-50 | 1 | 21,174 | Steve Carlton | Tom Seaver | Tom Seaver | Steve Carlton | | 647 | 461 | 186 |
| 1976-09-04 | @ NYN | 133 | L 3-7 | 82-51 | 1 | 16,022 | Jim Lonborg | Craig Swan | Nino Espinosa | Jim Lonborg | Skip Lockwood | 650 | 468 | 182 |
| 1976-09-05 | @ NYN | 134 | W 3-1 | 83-51 | 1 | 20,701 | Larry Christenson | Mickey Lolich | Larry Christenson | Mickey Lolich | Ron Reed | 653 | 469 | 184 |
| 1976-09-06 | @ PIT | 135 | L 2-6 | 83-53 | 1 | 0 | Jim Kaat | Bruce Kison | Bruce Kison | Jim Kaat | | 655 | 475 | 180 |
| 1976-09-06 | @ PIT | 136 | L 1-5 | 83-53 | 1 | 41,703 | Tom Underwood | Larry Demery | Larry Demery | Tom Underwood | | 656 | 480 | 176 |
| 1976-09-08 | @ PIT | 137 | L 1-6 | 83-54 | 1 | 30,976 | Steve Carlton | Jim Rooker | Jim Rooker | Steve Carlton | | 657 | 486 | 171 |
| 1976-09-09 | vs CHN | 138 | W 4-2 | 84-54 | 1 | 27,194 | Jim Lonborg | Bill Bonham | Jim Lonborg | Bill Bonham | | 661 | 488 | 173 |
| 1976-09-10 | vs CHN | 139 | L 2-3 | 84-55 | 1 | 30,121 | Jim Kaat | Rick Reuschel | Rick Reuschel | Jim Kaat | | 663 | 491 | 172 |
| 1976-09-11 | vs CHN | 140 | L 1-4 | 84-56 | 1 | 37,668 | Tom Underwood | Ray Burris | Bruce Sutter | Ron Reed | Joe Coleman | 664 | 495 | 169 |
| 1976-09-12 | vs CHN | 141 | W 8-0 | 85-56 | 1 | 34,469 | Larry Christenson | Steve Renko | Larry Christenson | Steve Renko | Tug McGraw | 672 | 495 | 177 |
| 1976-09-13 | vs MON | 142 | W 7-2 | 86-56 | 1 | 20,114 | Steve Carlton | Dennis Blair | Steve Carlton | Dennis Blair | Gene Garber | 679 | 497 | 182 |
| 1976-09-14 | vs MON | 143 | W 3-2 | 87-56 | 1 | 23,812 | Jim Lonborg | Woodie Fryman | Jim Lonborg | Woodie Fryman | Ron Reed | 682 | 499 | 183 |
| 1976-09-15 | vs PIT | 144 | L 2-7 | 87-57 | 1 | 45,010 | Jim Kaat | John Candelaria | John Candelaria | Jim Kaat | | 684 | 506 | 178 |
| 1976-09-16 | vs PIT | 145 | L 6-7 | 87-58 | 1 | 35,806 | Tom Underwood | Jerry Reuss | Kent Tekulve | Ron Reed | | 690 | 513 | 177 |
| 1976-09-17 | @ CHN | 146 | L 3-4 | 87-59 | 1 | 3,631 | Larry Christenson | Bill Bonham | Bruce Sutter | Ron Reed | | 693 | 517 | 176 |
| 1976-09-18 | @ CHN | 147 | W 4-1 | 88-59 | 1 | 15,938 | Steve Carlton | Rick Reuschel | Steve Carlton | Rick Reuschel | | 697 | 518 | 179 |
| 1976-09-19 | @ CHN | 148 | L 0-1 | 88-60 | 1 | 17,764 | Jim Lonborg | Ray Burris | Ray Burris | Jim Lonborg | | 697 | 519 | 178 |
| 1976-09-21 | vs SLN | 149 | W 5-1 | 89-60 | 1 | 20,261 | Tom Underwood | John Denny | Tom Underwood | John Denny | Tug McGraw | 702 | 520 | 182 |
| 1976-09-22 | vs SLN | 150 | W 9-4 | 90-60 | 1 | 27,423 | Jim Kaat | Pete Falcone | Gene Garber | Tom Walker | | 711 | 524 | 187 |
| 1976-09-23 | vs SLN | 151 | W 7-3 | 91-60 | 1 | 29,018 | Steve Carlton | Eric Rasmussen | Steve Carlton | Eric Rasmussen | | 718 | 527 | 191 |
| 1976-09-24 | @ MON | 152 | W 9-3 | 92-61 | 1 | 0 | Larry Christenson | Steve Rogers | Larry Christenson | Steve Rogers | Gene Garber | 727 | 530 | 197 |
| 1976-09-24 | @ MON | 153 | L 2-3 | 92-61 | 1 | 4,510 | Jim Kaat | Don Stanhouse | Don Stanhouse | Jim Kaat | | 729 | 533 | 196 |
| 1976-09-25 | @ MON | 154 | W 6-5 | 93-61 | 1 | 5,096 | Tom Underwood | Woodie Fryman | Wayne Twitchell | Woodie Fryman | Gene Garber | 735 | 538 | 197 |
| 1976-09-26 | @ MON | 155 | W 4-1 | 95-61 | 1 | 0 | Jim Lonborg | Dan Warthen | Jim Lonborg | Dan Warthen | | 739 | 539 | 200 |
| 1976-09-26 | @ MON | 156 | W 2-1 | 95-61 | 1 | 14,166 | Ron Reed | Dennis Blair | Ron Schueler | Dennis Blair | | 741 | 540 | 201 |
| 1976-09-27 | @ SLN | 157 | W 9-1 | 96-61 | 1 | 6,199 | Jim Kaat | Pete Falcone | Jim Kaat | Pete Falcone | Randy Lerch | 750 | 541 | 209 |
| 1976-09-28 | @ SLN | 158 | L 3-5 | 96-62 | 1 | 5,793 | Steve Carlton | Eric Rasmussen | Eric Rasmussen | Steve Carlton | | 753 | 546 | 207 |
| 1976-09-29 | @ SLN | 159 | W 6-5 | 97-62 | 1 | 5,992 | Larry Christenson | Bob Forsch | Tug McGraw | John Curtis | Wayne Twitchell | 759 | 551 | 208 |
| 1976-10-01 | vs NYN | 160 | W 2-1 | 98-62 | 1 | 23,084 | Tom Underwood | Jerry Koosman | Gene Garber | Jerry Koosman | | 761 | 552 | 209 |
| 1976-10-02 | vs NYN | 161 | W 7-4 | 99-62 | 1 | 47,095 | Jim Lonborg | Jon Matlack | Jim Lonborg | Jon Matlack | Tug McGraw | 768 | 556 | 212 |
| 1976-10-03 | vs NYN | 162 | W 2-1 | 100-62 | 1 | 25,632 | Steve Carlton | Craig Swan | Steve Carlton | Craig Swan | | 770 | 557 | 213 |