| 1976-04-09 | @ CAL | 1 | W 5-2 | 1-0 | 2 | 30,194 | Mike Torrez | Frank Tanana | Mike Torrez | Frank Tanana | Rollie Fingers | 5 | 2 | 3 |
| 1976-04-10 | @ CAL | 2 | W 6-2 | 2-0 | 2 | 10,143 | Vida Blue | Nolan Ryan | Vida Blue | Nolan Ryan | Rollie Fingers | 11 | 4 | 7 |
| 1976-04-11 | @ CAL | 3 | W 10-7 | 3-0 | 2 | 16,106 | Stan Bahnsen | Don Kirkwood | Stan Bahnsen | Don Kirkwood | Jim Todd | 21 | 11 | 10 |
| 1976-04-12 | @ TEX | 4 | L 1-5 | 3-1 | 2 | 6,219 | Paul Mitchell | Nelson Briles | Nelson Briles | Paul Mitchell | | 22 | 16 | 6 |
| 1976-04-13 | @ TEX | 5 | L 1-3 | 3-2 | 3 | 9,321 | Mike Torrez | Steve Barr | Steve Barr | Mike Torrez | | 23 | 19 | 4 |
| 1976-04-14 | @ TEX | 6 | L 2-4 | 3-3 | 3 | 22,920 | Vida Blue | Gaylord Perry | Gaylord Perry | Vida Blue | | 25 | 23 | 2 |
| 1976-04-17 | vs BAL | 7 | L 1-6 | 3-4 | 4 | 28,017 | Mike Torrez | Jim Palmer | Jim Palmer | Mike Torrez | | 26 | 29 | -3 |
| 1976-04-18 | vs BAL | 8 | W 2-1 | 4-4 | 3 | 7,680 | Vida Blue | Ken Holtzman | Rollie Fingers | Dyar Miller | | 28 | 30 | -2 |
| 1976-04-19 | vs DET | 9 | W 6-5 | 5-4 | 3 | 18,753 | Stan Bahnsen | Vern Ruhle | Jim Todd | John Hiller | | 34 | 35 | -1 |
| 1976-04-20 | vs DET | 10 | W 6-5 | 6-4 | 1 | 3,080 | Paul Mitchell | Joe Coleman | Paul Lindblad | Jim Crawford | | 40 | 40 | 0 |
| 1976-04-21 | vs DET | 11 | L 3-7 | 6-5 | 2 | 2,408 | Mike Torrez | Dave Roberts | Dave Roberts | Mike Torrez | | 43 | 47 | -4 |
| 1976-04-23 | @ CLE | 12 | L 0-3 | 6-6 | 3 | 9,581 | Vida Blue | Dennis Eckersley | Dennis Eckersley | Vida Blue | | 43 | 50 | -7 |
| 1976-04-24 | @ CLE | 13 | W 8-7 | 7-6 | 2 | 17,509 | Mike Norris | Fritz Peterson | Rollie Fingers | Tom Buskey | Jim Todd | 51 | 57 | -6 |
| 1976-04-25 | @ CLE | 14 | W 9-1 | 8-6 | 2 | 5,138 | Mike Torrez | Pat Dobson | Mike Torrez | Pat Dobson | | 60 | 58 | 2 |
| 1976-04-27 | @ DET | 15 | L 2-10 | 8-7 | 2 | 4,612 | Vida Blue | Joe Coleman | Joe Coleman | Vida Blue | Bill Laxton | 62 | 68 | -6 |
| 1976-04-28 | @ DET | 16 | L 1-8 | 8-8 | 2 | 7,088 | Mike Norris | Dave Roberts | Dave Roberts | Mike Norris | | 63 | 76 | -13 |
| 1976-04-30 | @ BAL | 17 | W 11-1 | 9-8 | 2 | 12,501 | Mike Torrez | Jim Palmer | Mike Torrez | Jim Palmer | | 74 | 77 | -3 |
| 1976-05-02 | @ BAL | 18 | W 6-2 | 10-9 | 2 | 0 | Vida Blue | Ross Grimsley | Vida Blue | Ross Grimsley | | 80 | 79 | 1 |
| 1976-05-02 | @ BAL | 19 | L 3-4 | 10-9 | 2 | 24,819 | Mike Norris | Mike Cuellar | Wayne Garland | Glenn Abbott | | 83 | 83 | 0 |
| 1976-05-03 | vs CLE | 20 | L 4-5 | 10-10 | 3 | 19,765 | Dick Bosman | Dennis Eckersley | Tom Buskey | Rollie Fingers | Dave LaRoche | 87 | 88 | -1 |
| 1976-05-04 | vs CLE | 21 | W 8-4 | 11-10 | 3 | 2,628 | Mike Torrez | Fritz Peterson | Mike Torrez | Fritz Peterson | Rollie Fingers | 95 | 92 | 3 |
| 1976-05-05 | vs CLE | 22 | L 1-3 | 11-11 | 3 | 2,100 | Stan Bahnsen | Pat Dobson | Pat Dobson | Rollie Fingers | | 96 | 95 | 1 |
| 1976-05-07 | vs NYA | 23 | L 4-14 | 11-12 | 3 | 6,810 | Vida Blue | Rudy May | Rudy May | Vida Blue | Dick Tidrow | 100 | 109 | -9 |
| 1976-05-08 | vs NYA | 24 | L 4-8 | 11-13 | 4 | 8,687 | Glenn Abbott | Dock Ellis | Dick Tidrow | Jim Todd | | 104 | 117 | -13 |
| 1976-05-09 | vs NYA | 25 | W 4-3 | 12-13 | 4 | 11,144 | Mike Torrez | Catfish Hunter | Paul Lindblad | Catfish Hunter | | 108 | 120 | -12 |
| 1976-05-10 | vs CAL | 26 | W 6-3 | 13-13 | 4 | 15,238 | Paul Mitchell | Nolan Ryan | Paul Mitchell | Nolan Ryan | | 114 | 123 | -9 |
| 1976-05-11 | vs CAL | 27 | W 6-4 | 14-13 | 3 | 2,951 | Vida Blue | Gary Ross | Jim Todd | Dick Drago | | 120 | 127 | -7 |
| 1976-05-14 | vs TEX | 28 | L 3-4 | 14-14 | 4 | 5,196 | Mike Torrez | Gaylord Perry | Gaylord Perry | Rollie Fingers | | 123 | 131 | -8 |
| 1976-05-15 | vs TEX | 29 | L 4-6 | 14-15 | 4 | 5,039 | Paul Mitchell | Nelson Briles | Steve Foucault | Jim Todd | | 127 | 137 | -10 |
| 1976-05-16 | vs TEX | 30 | W 3-2 | 15-15 | 4 | 4,940 | Vida Blue | Steve Barr | Vida Blue | Steve Barr | | 130 | 139 | -9 |
| 1976-05-17 | @ MIN | 31 | L 4-5 | 15-16 | 4 | 8,034 | Mike Norris | Joe Decker | Bill Campbell | Jim Todd | | 134 | 144 | -10 |
| 1976-05-18 | @ MIN | 32 | L 3-4 | 15-17 | 4 | 6,600 | Stan Bahnsen | Dave Goltz | Dave Goltz | Jim Todd | | 137 | 148 | -11 |
| 1976-05-19 | @ KCA | 33 | L 2-5 | 15-18 | 4 | 22,483 | Mike Torrez | Paul Splittorff | Paul Splittorff | Mike Torrez | Marty Pattin | 139 | 153 | -14 |
| 1976-05-20 | @ KCA | 34 | L 4-8 | 15-19 | 4 | 25,682 | Paul Mitchell | Doug Bird | Doug Bird | Paul Mitchell | Mark Littell | 143 | 161 | -18 |
| 1976-05-21 | @ CHA | 35 | L 0-6 | 15-20 | 5 | 22,420 | Vida Blue | Ken Brett | Ken Brett | Vida Blue | Clay Carroll | 143 | 167 | -24 |
| 1976-05-22 | @ CHA | 36 | L 2-7 | 15-21 | 5 | 16,797 | Mike Norris | Jesse Jefferson | Jesse Jefferson | Mike Norris | | 145 | 174 | -29 |
| 1976-05-23 | @ CHA | 37 | L 1-3 | 15-23 | 5 | 0 | Mike Torrez | Terry Forster | Clay Carroll | Mike Torrez | | 146 | 177 | -31 |
| 1976-05-23 | @ CHA | 38 | L 3-4 | 15-23 | 5 | 21,539 | Stan Bahnsen | Bart Johnson | Bart Johnson | Stan Bahnsen | Clay Carroll | 149 | 181 | -32 |
| 1976-05-24 | vs MIN | 39 | W 12-7 | 16-23 | 5 | 13,624 | Dick Bosman | Steve Luebber | Jim Todd | Bill Campbell | | 161 | 188 | -27 |
| 1976-05-25 | vs MIN | 40 | W 6-1 | 17-23 | 5 | 1,960 | Vida Blue | Jim Hughes | Vida Blue | Jim Hughes | | 167 | 189 | -22 |
| 1976-05-26 | vs MIN | 41 | L 1-6 | 17-24 | 5 | 2,740 | Paul Mitchell | Dave Goltz | Dave Goltz | Paul Mitchell | | 168 | 195 | -27 |
| 1976-05-27 | vs MIN | 42 | W 5-3 | 18-24 | 5 | 3,720 | Mike Torrez | Bert Blyleven | Mike Torrez | Bert Blyleven | Rollie Fingers | 173 | 198 | -25 |
| 1976-05-28 | vs CHA | 43 | W 11-0 | 19-24 | 5 | 3,688 | Stan Bahnsen | Bart Johnson | Stan Bahnsen | Bart Johnson | | 184 | 198 | -14 |
| 1976-05-29 | vs CHA | 44 | W 2-0 | 20-24 | 5 | 4,988 | Vida Blue | Terry Forster | Vida Blue | Terry Forster | | 186 | 198 | -12 |
| 1976-05-30 | vs CHA | 45 | L 3-4 | 20-25 | 5 | 6,056 | Dick Bosman | Rich Gossage | Clay Carroll | Rollie Fingers | Dave Hamilton | 189 | 202 | -13 |
| 1976-05-31 | vs KCA | 46 | W 10-1 | 21-25 | 5 | 31,842 | Mike Torrez | Paul Splittorff | Mike Torrez | Paul Splittorff | | 199 | 203 | -4 |
| 1976-06-01 | vs KCA | 47 | L 2-5 | 21-26 | 5 | 3,860 | Stan Bahnsen | Doug Bird | Doug Bird | Stan Bahnsen | Marty Pattin | 201 | 208 | -7 |
| 1976-06-02 | vs KCA | 48 | L 3-4 | 21-27 | 5 | 2,628 | Vida Blue | Steve Busby | Mark Littell | Rollie Fingers | Steve Mingori | 204 | 212 | -8 |
| 1976-06-04 | @ NYA | 49 | W 6-4 | 22-27 | 5 | 44,944 | Paul Mitchell | Catfish Hunter | Jim Todd | Sparky Lyle | | 210 | 216 | -6 |
| 1976-06-05 | @ NYA | 50 | W 7-6 | 23-27 | 5 | 26,756 | Mike Torrez | Rudy May | Rollie Fingers | Sparky Lyle | | 217 | 222 | -5 |
| 1976-06-06 | @ NYA | 51 | W 3-2 | 24-28 | 5 | 0 | Vida Blue | Ed Figueroa | Vida Blue | Ed Figueroa | Rollie Fingers | 220 | 224 | -4 |
| 1976-06-06 | @ NYA | 52 | L 2-5 | 24-28 | 5 | 47,431 | Stan Bahnsen | Dave Pagan | Dave Pagan | Paul Lindblad | | 222 | 229 | -7 |
| 1976-06-08 | @ BOS | 53 | W 6-5 | 25-28 | 5 | 26,704 | Paul Mitchell | Luis Tiant | Jim Todd | Reggie Cleveland | Rollie Fingers | 228 | 234 | -6 |
| 1976-06-09 | @ BOS | 54 | L 4-6 | 25-29 | 5 | 24,191 | Mike Torrez | Rick Wise | Rick Wise | Mike Torrez | Tom House | 232 | 240 | -8 |
| 1976-06-10 | @ BOS | 55 | W 8-5 | 26-29 | 5 | 27,364 | Stan Bahnsen | Fergie Jenkins | Jim Todd | Tom Murphy | Rollie Fingers | 240 | 245 | -5 |
| 1976-06-11 | @ MIL | 56 | L 2-4 | 26-30 | 5 | 19,059 | Vida Blue | Jim Colborn | Jim Colborn | Vida Blue | | 242 | 249 | -7 |
| 1976-06-12 | @ MIL | 57 | W 2-1 | 27-30 | 5 | 29,025 | Paul Mitchell | Bill Travers | Paul Mitchell | Bill Travers | Rollie Fingers | 244 | 250 | -6 |
| 1976-06-13 | @ MIL | 58 | L 4-5 | 27-31 | 5 | 31,457 | Mike Torrez | Jim Slaton | Jim Slaton | Mike Torrez | Bill Castro | 248 | 255 | -7 |
| 1976-06-15 | vs BOS | 59 | W 3-2 | 28-31 | 5 | 11,306 | Glenn Abbott | Fergie Jenkins | Paul Lindblad | Fergie Jenkins | | 251 | 257 | -6 |
| 1976-06-16 | vs BOS | 60 | W 4-1 | 29-31 | 4 | 5,925 | Paul Mitchell | Luis Tiant | Paul Mitchell | Luis Tiant | | 255 | 258 | -3 |
| 1976-06-17 | vs BOS | 61 | L 3-8 | 29-32 | 5 | 8,163 | Mike Torrez | Dick Pole | Dick Pole | Mike Torrez | | 258 | 266 | -8 |
| 1976-06-18 | vs MIL | 62 | L 2-3 | 29-33 | 5 | 4,108 | Dick Bosman | Jerry Augustine | Bill Castro | Jim Todd | | 260 | 269 | -9 |
| 1976-06-19 | vs MIL | 63 | W 7-4 | 30-33 | 4 | 23,408 | Glenn Abbott | Jim Colborn | Glenn Abbott | Jim Colborn | Paul Lindblad | 267 | 273 | -6 |
| 1976-06-20 | vs MIL | 64 | W 7-5 | 31-33 | 3 | 7,462 | Mike Torrez | Bill Travers | Stan Bahnsen | Bill Travers | Jim Todd | 274 | 278 | -4 |
| 1976-06-21 | vs TEX | 65 | L 0-1 | 31-34 | 3 | 21,800 | Paul Mitchell | Bert Blyleven | Bert Blyleven | Paul Mitchell | | 274 | 279 | -5 |
| 1976-06-22 | vs TEX | 66 | W 5-2 | 32-34 | 3 | 4,811 | Dick Bosman | Nelson Briles | Dick Bosman | Nelson Briles | Paul Lindblad | 279 | 281 | -2 |
| 1976-06-23 | @ CAL | 67 | W 8-2 | 33-34 | 3 | 14,289 | Mike Norris | Andy Hassler | Mike Norris | Andy Hassler | | 287 | 283 | 4 |
| 1976-06-24 | @ CAL | 68 | L 1-2 | 33-35 | 3 | 11,052 | Glenn Abbott | Sid Monge | Sid Monge | Glenn Abbott | Dick Drago | 288 | 285 | 3 |
| 1976-06-25 | vs MIN | 69 | W 5-2 | 34-35 | 3 | 5,100 | Mike Torrez | Dave Goltz | Paul Lindblad | Dave Goltz | | 293 | 287 | 6 |
| 1976-06-26 | vs MIN | 70 | L 3-11 | 34-36 | 3 | 4,729 | Paul Mitchell | Jim Hughes | Jim Hughes | Paul Mitchell | | 296 | 298 | -2 |
| 1976-06-27 | vs MIN | 71 | W 5-3 | 35-36 | 3 | 4,798 | Dick Bosman | Pete Redfern | Dick Bosman | Pete Redfern | Rollie Fingers | 301 | 301 | 0 |
| 1976-06-28 | @ TEX | 72 | L 2-3 | 35-37 | 3 | 13,679 | Mike Norris | Jim Umbarger | Steve Foucault | Jim Todd | | 303 | 304 | -1 |
| 1976-06-29 | @ TEX | 73 | W 8-3 | 36-37 | 3 | 13,964 | Glenn Abbott | Steve Barr | Stan Bahnsen | Steve Barr | Rollie Fingers | 311 | 307 | 4 |
| 1976-06-30 | @ TEX | 74 | L 2-3 | 36-38 | 3 | 14,936 | Mike Torrez | Gaylord Perry | Gaylord Perry | Mike Torrez | Steve Foucault | 313 | 310 | 3 |
| 1976-07-01 | @ KCA | 75 | W 5-2 | 37-38 | 3 | 23,175 | Paul Mitchell | Doug Bird | Rollie Fingers | Marty Pattin | | 318 | 312 | 6 |
| 1976-07-02 | @ KCA | 76 | L 5-8 | 37-39 | 3 | 25,723 | Vida Blue | Steve Busby | Mark Littell | Vida Blue | | 323 | 320 | 3 |
| 1976-07-03 | @ KCA | 77 | L 5-7 | 37-40 | 3 | 33,586 | Dick Bosman | Dennis Leonard | Dennis Leonard | Jim Todd | Steve Mingori | 328 | 327 | 1 |
| 1976-07-04 | @ KCA | 78 | W 6-0 | 38-40 | 3 | 24,647 | Mike Norris | Al Fitzmorris | Mike Norris | Al Fitzmorris | | 334 | 327 | 7 |
| 1976-07-05 | vs BAL | 79 | W 4-1 | 39-40 | 3 | 40,502 | Mike Torrez | Rudy May | Mike Torrez | Rudy May | Rollie Fingers | 338 | 328 | 10 |
| 1976-07-06 | vs BAL | 80 | W 2-0 | 40-40 | 3 | 6,024 | Vida Blue | Jim Palmer | Vida Blue | Jim Palmer | | 340 | 328 | 12 |
| 1976-07-07 | vs BAL | 81 | W 5-3 | 41-40 | 3 | 4,681 | Paul Mitchell | Mike Cuellar | Paul Mitchell | Mike Cuellar | Rollie Fingers | 345 | 331 | 14 |
| 1976-07-08 | vs BAL | 82 | L 6-9 | 41-41 | 3 | 3,798 | Mike Norris | Wayne Garland | Wayne Garland | Paul Lindblad | Dyar Miller | 351 | 340 | 11 |
| 1976-07-09 | vs CLE | 83 | W 2-1 | 42-41 | 3 | 4,480 | Mike Torrez | Jackie Brown | Mike Torrez | Jackie Brown | | 353 | 341 | 12 |
| 1976-07-10 | vs CLE | 84 | W 7-3 | 43-41 | 3 | 22,149 | Vida Blue | Pat Dobson | Rollie Fingers | Pat Dobson | | 360 | 344 | 16 |
| 1976-07-11 | vs CLE | 85 | W 9-3 | 44-41 | 3 | 7,156 | Paul Mitchell | Dennis Eckersley | Paul Mitchell | Dennis Eckersley | Paul Lindblad | 369 | 347 | 22 |
| 1976-07-15 | @ DET | 86 | L 2-3 | 44-42 | 3 | 14,835 | Vida Blue | Dave Roberts | Dave Roberts | Vida Blue | | 371 | 350 | 21 |
| 1976-07-16 | @ DET | 87 | L 0-1 | 44-43 | 3 | 45,905 | Mike Torrez | Mark Fidrych | Mark Fidrych | Rollie Fingers | | 371 | 351 | 20 |
| 1976-07-17 | @ DET | 88 | W 3-0 | 45-43 | 3 | 30,110 | Mike Norris | Vern Ruhle | Mike Norris | Vern Ruhle | Rollie Fingers | 374 | 351 | 23 |
| 1976-07-18 | @ DET | 89 | W 10-1 | 46-43 | 3 | 23,841 | Paul Mitchell | Frank MacCormack | Paul Mitchell | Frank MacCormack | | 384 | 352 | 32 |
| 1976-07-19 | @ CLE | 90 | L 2-3 | 47-44 | 3 | 0 | Vida Blue | Jim Bibby | Jim Bibby | Vida Blue | Jim Kern | 386 | 355 | 31 |
| 1976-07-19 | @ CLE | 91 | W 10-3 | 47-44 | 3 | 24,682 | Dick Bosman | Jackie Brown | Dick Bosman | Jackie Brown | | 396 | 358 | 38 |
| 1976-07-20 | @ CLE | 92 | W 7-4 | 48-44 | 2 | 11,315 | Glenn Abbott | Pat Dobson | Rollie Fingers | Dave LaRoche | | 403 | 362 | 41 |
| 1976-07-21 | @ NYA | 93 | L 1-10 | 48-45 | 2 | 26,451 | Mike Norris | Catfish Hunter | Catfish Hunter | Mike Norris | | 404 | 372 | 32 |
| 1976-07-22 | @ NYA | 94 | W 6-5 | 49-45 | 2 | 32,843 | Paul Mitchell | Dock Ellis | Rollie Fingers | Dick Tidrow | | 410 | 377 | 33 |
| 1976-07-23 | vs KCA | 95 | W 2-0 | 50-45 | 2 | 9,173 | Vida Blue | Marty Pattin | Vida Blue | Marty Pattin | | 412 | 377 | 35 |
| 1976-07-24 | vs KCA | 96 | L 5-6 | 50-46 | 2 | 42,592 | Dick Bosman | Dennis Leonard | Dennis Leonard | Jim Todd | Steve Mingori | 417 | 383 | 34 |
| 1976-07-25 | vs KCA | 97 | W 9-2 | 51-46 | 2 | 10,237 | Mike Norris | Doug Bird | Glenn Abbott | Doug Bird | | 426 | 385 | 41 |
| 1976-07-26 | vs CHA | 98 | W 3-1 | 52-46 | 2 | 23,182 | Paul Mitchell | Bart Johnson | Paul Mitchell | Bart Johnson | Rollie Fingers | 429 | 386 | 43 |
| 1976-07-27 | vs CHA | 99 | W 1-0 | 53-46 | 2 | 3,442 | Vida Blue | Rich Gossage | Vida Blue | Rich Gossage | | 430 | 386 | 44 |
| 1976-07-28 | vs CHA | 100 | L 1-2 | 53-47 | 2 | 3,367 | Mike Torrez | Blue Moon Odom | Blue Moon Odom | Paul Lindblad | Francisco Barrios | 431 | 388 | 43 |
| 1976-07-30 | @ MIN | 101 | L 7-8 | 53-48 | 2 | 12,342 | Dick Bosman | Bill Singer | Tom Burgmeier | Rollie Fingers | | 438 | 396 | 42 |
| 1976-07-31 | @ MIN | 102 | L 5-6 | 53-49 | 2 | 13,515 | Paul Mitchell | Dave Goltz | Dave Goltz | Stan Bahnsen | Bill Campbell | 443 | 402 | 41 |
| 1976-08-01 | @ MIN | 103 | L 7-8 | 53-51 | 3 | 0 | Vida Blue | Pete Redfern | Bill Campbell | Paul Lindblad | | 450 | 410 | 40 |
| 1976-08-01 | @ MIN | 104 | L 2-6 | 53-51 | 3 | 22,921 | Glenn Abbott | Jim Hughes | Tom Johnson | Glenn Abbott | | 452 | 416 | 36 |
| 1976-08-02 | @ MIN | 105 | L 0-3 | 53-52 | 3 | 14,833 | Mike Torrez | Steve Luebber | Steve Luebber | Mike Torrez | | 452 | 419 | 33 |
| 1976-08-03 | @ CHA | 106 | W 7-3 | 54-52 | 3 | 10,063 | Dick Bosman | Blue Moon Odom | Dick Bosman | Blue Moon Odom | Rollie Fingers | 459 | 422 | 37 |
| 1976-08-04 | @ CHA | 107 | W 5-0 | 55-52 | 2 | 8,892 | Paul Mitchell | Ken Brett | Paul Mitchell | Ken Brett | | 464 | 422 | 42 |
| 1976-08-06 | vs CAL | 108 | L 1-2 | 55-53 | 2 | 5,777 | Vida Blue | Frank Tanana | Frank Tanana | Vida Blue | | 465 | 424 | 41 |
| 1976-08-07 | vs CAL | 109 | W 9-1 | 56-53 | 2 | 5,520 | Mike Torrez | Don Kirkwood | Mike Torrez | Don Kirkwood | | 474 | 425 | 49 |
| 1976-08-08 | vs CAL | 110 | W 9-3 | 58-53 | 2 | 0 | Paul Mitchell | Sid Monge | Stan Bahnsen | Sid Monge | Rollie Fingers | 483 | 428 | 55 |
| 1976-08-08 | vs CAL | 111 | W 13-8 | 58-53 | 2 | 11,778 | Mike Norris | Nolan Ryan | Paul Lindblad | Nolan Ryan | Rollie Fingers | 496 | 436 | 60 |
| 1976-08-10 | vs MIL | 112 | W 2-1 | 59-53 | 2 | 4,463 | Vida Blue | Jim Slaton | Vida Blue | Jim Slaton | | 498 | 437 | 61 |
| 1976-08-11 | vs MIL | 113 | W 8-5 | 60-53 | 2 | 3,395 | Mike Torrez | Bill Travers | Mike Torrez | Bill Travers | | 506 | 442 | 64 |
| 1976-08-12 | vs MIL | 114 | W 4-3 | 61-53 | 2 | 3,730 | Paul Mitchell | Eduardo Rodriguez | Rollie Fingers | Bill Castro | | 510 | 445 | 65 |
| 1976-08-13 | vs BOS | 115 | W 2-0 | 62-53 | 2 | 6,156 | Mike Norris | Reggie Cleveland | Mike Norris | Reggie Cleveland | Rollie Fingers | 512 | 445 | 67 |
| 1976-08-14 | vs BOS | 116 | W 7-3 | 63-53 | 2 | 7,066 | Vida Blue | Fergie Jenkins | Vida Blue | Fergie Jenkins | | 519 | 448 | 71 |
| 1976-08-15 | vs BOS | 117 | W 8-7 | 64-53 | 2 | 9,087 | Mike Torrez | Rick Wise | Stan Bahnsen | Jim Willoughby | | 527 | 455 | 72 |
| 1976-08-16 | @ MIL | 118 | L 3-4 | 64-54 | 2 | 9,019 | Dick Bosman | Jim Colborn | Danny Frisella | Rollie Fingers | | 530 | 459 | 71 |
| 1976-08-17 | @ MIL | 119 | W 5-4 | 65-54 | 2 | 14,736 | Mike Norris | Eduardo Rodriguez | Paul Lindblad | Eduardo Rodriguez | Rollie Fingers | 535 | 463 | 72 |
| 1976-08-18 | @ MIL | 120 | L 1-3 | 65-55 | 2 | 13,013 | Vida Blue | Jim Slaton | Jim Slaton | Vida Blue | Ray Sadecki | 536 | 466 | 70 |
| 1976-08-20 | @ BOS | 121 | L 1-2 | 65-56 | 2 | 30,132 | Mike Torrez | Luis Tiant | Luis Tiant | Rollie Fingers | | 537 | 468 | 69 |
| 1976-08-21 | @ BOS | 122 | L 2-5 | 65-57 | 2 | 27,299 | Dick Bosman | Reggie Cleveland | Reggie Cleveland | Dick Bosman | Tom Murphy | 539 | 473 | 66 |
| 1976-08-22 | @ BOS | 123 | W 7-6 | 66-57 | 2 | 27,526 | Mike Norris | Fergie Jenkins | Rollie Fingers | Jim Willoughby | | 546 | 479 | 67 |
| 1976-08-23 | @ BAL | 124 | W 3-0 | 67-57 | 2 | 13,618 | Vida Blue | Mike Flanagan | Vida Blue | Mike Flanagan | | 549 | 479 | 70 |
| 1976-08-24 | @ BAL | 125 | W 5-4 | 68-57 | 2 | 9,482 | Mike Torrez | Wayne Garland | Stan Bahnsen | Wayne Garland | Paul Lindblad | 554 | 483 | 71 |
| 1976-08-25 | @ BAL | 126 | L 4-9 | 68-58 | 2 | 6,942 | Paul Mitchell | Rudy May | Rudy May | Paul Mitchell | | 558 | 492 | 66 |
| 1976-08-27 | vs DET | 127 | L 1-8 | 68-59 | 2 | 5,884 | Glenn Abbott | Vern Ruhle | Vern Ruhle | Glenn Abbott | | 559 | 500 | 59 |
| 1976-08-28 | vs DET | 128 | W 5-2 | 69-59 | 2 | 9,252 | Vida Blue | Dave Roberts | Vida Blue | Dave Roberts | | 564 | 502 | 62 |
| 1976-08-29 | vs DET | 129 | W 2-1 | 70-59 | 2 | 25,659 | Mike Torrez | Mark Fidrych | Rollie Fingers | Mark Fidrych | | 566 | 503 | 63 |
| 1976-08-30 | vs NYA | 130 | L 2-5 | 70-60 | 2 | 32,458 | Mike Norris | Ed Figueroa | Ed Figueroa | Mike Norris | | 568 | 508 | 60 |
| 1976-08-31 | vs NYA | 131 | L 1-2 | 70-61 | 2 | 6,408 | Stan Bahnsen | Doyle Alexander | Doyle Alexander | Stan Bahnsen | | 569 | 510 | 59 |
| 1976-09-01 | vs NYA | 132 | W 5-0 | 71-61 | 2 | 8,881 | Vida Blue | Catfish Hunter | Vida Blue | Catfish Hunter | | 574 | 510 | 64 |
| 1976-09-03 | @ CAL | 133 | W 3-0 | 72-61 | 2 | 7,772 | Mike Torrez | Gary Ross | Mike Torrez | Gary Ross | | 577 | 510 | 67 |
| 1976-09-04 | @ CAL | 134 | L 1-5 | 72-62 | 2 | 14,827 | Mike Norris | Paul Hartzell | Paul Hartzell | Mike Norris | | 578 | 515 | 63 |
| 1976-09-05 | @ CAL | 135 | L 2-3 | 72-63 | 2 | 7,604 | Stan Bahnsen | Nolan Ryan | Nolan Ryan | Stan Bahnsen | | 580 | 518 | 62 |
| 1976-09-06 | @ CAL | 136 | W 2-1 | 73-63 | 2 | 16,377 | Vida Blue | Frank Tanana | Rollie Fingers | John Verhoeven | | 582 | 519 | 63 |
| 1976-09-07 | vs CHA | 137 | W 4-0 | 74-63 | 2 | 3,461 | Mike Torrez | Terry Forster | Mike Torrez | Terry Forster | | 586 | 519 | 67 |
| 1976-09-08 | vs CHA | 138 | L 5-6 | 74-64 | 2 | 5,328 | Dick Bosman | Rich Gossage | Chris Knapp | Rollie Fingers | | 591 | 525 | 66 |
| 1976-09-09 | vs CHA | 139 | W 2-1 | 75-64 | 2 | 6,617 | Mike Norris | Ken Brett | Jim Todd | Ken Brett | Rollie Fingers | 593 | 526 | 67 |
| 1976-09-10 | @ TEX | 140 | L 4-5 | 75-65 | 2 | 7,297 | Vida Blue | Bert Blyleven | Mike Bacsik | Vida Blue | | 597 | 531 | 66 |
| 1976-09-11 | @ TEX | 141 | W 1-0 | 76-65 | 2 | 9,554 | Mike Torrez | Nelson Briles | Mike Torrez | Nelson Briles | | 598 | 531 | 67 |
| 1976-09-12 | @ TEX | 142 | W 9-6 | 77-65 | 2 | 5,070 | Stan Bahnsen | Gaylord Perry | Stan Bahnsen | Gaylord Perry | Jim Todd | 607 | 537 | 70 |
| 1976-09-14 | @ MIN | 143 | W 4-2 | 78-66 | 2 | 0 | Vida Blue | Steve Luebber | Vida Blue | Steve Luebber | | 611 | 539 | 72 |
| 1976-09-14 | @ MIN | 144 | L 3-4 | 78-66 | 2 | 2,923 | Dick Bosman | Dave Goltz | Dave Goltz | Paul Lindblad | | 614 | 543 | 71 |
| 1976-09-15 | vs MIN | 145 | W 5-2 | 79-66 | 2 | 3,774 | Mike Torrez | Jim Hughes | Mike Torrez | Jim Hughes | | 619 | 545 | 74 |
| 1976-09-16 | vs MIN | 146 | L 0-4 | 79-67 | 2 | 4,587 | Stan Bahnsen | Bill Singer | Bill Singer | Stan Bahnsen | | 619 | 549 | 70 |
| 1976-09-17 | vs TEX | 147 | L 3-4 | 79-68 | 2 | 9,073 | Glenn Abbott | Gaylord Perry | Gaylord Perry | Dick Bosman | | 622 | 553 | 69 |
| 1976-09-18 | vs TEX | 148 | W 3-2 | 80-68 | 2 | 6,014 | Vida Blue | Tommy Boggs | Vida Blue | Tommy Boggs | Paul Lindblad | 625 | 555 | 70 |
| 1976-09-19 | vs TEX | 149 | L 1-9 | 81-69 | 2 | 0 | Mike Torrez | Jim Umbarger | Jim Umbarger | Mike Torrez | | 626 | 564 | 62 |
| 1976-09-19 | vs TEX | 150 | W 13-3 | 81-69 | 2 | 11,421 | Paul Mitchell | Steve Hargan | Paul Mitchell | Steve Hargan | | 639 | 567 | 72 |
| 1976-09-21 | @ KCA | 151 | L 1-3 | 81-70 | 2 | 28,869 | Stan Bahnsen | Doug Bird | Doug Bird | Stan Bahnsen | Larry Gura | 640 | 570 | 70 |
| 1976-09-22 | @ KCA | 152 | W 11-1 | 82-70 | 2 | 36,064 | Vida Blue | Marty Pattin | Vida Blue | Marty Pattin | | 651 | 571 | 80 |
| 1976-09-23 | @ KCA | 153 | W 8-1 | 83-70 | 2 | 34,077 | Mike Torrez | Dennis Leonard | Mike Torrez | Dennis Leonard | | 659 | 572 | 87 |
| 1976-09-24 | @ CHA | 154 | L 2-4 | 83-71 | 2 | 12,672 | Paul Mitchell | Francisco Barrios | Francisco Barrios | Rollie Fingers | | 661 | 576 | 85 |
| 1976-09-25 | @ CHA | 155 | W 7-4 | 84-71 | 2 | 17,298 | Glenn Abbott | Rich Gossage | Rollie Fingers | Rich Gossage | | 668 | 580 | 88 |
| 1976-09-27 | vs KCA | 156 | W 8-3 | 85-71 | 2 | 37,914 | Vida Blue | Dennis Leonard | Vida Blue | Dennis Leonard | | 676 | 583 | 93 |
| 1976-09-28 | vs KCA | 157 | W 1-0 | 86-71 | 2 | 9,464 | Mike Torrez | Marty Pattin | Mike Torrez | Marty Pattin | | 677 | 583 | 94 |
| 1976-09-29 | vs KCA | 158 | L 0-4 | 86-72 | 2 | 19,631 | Paul Mitchell | Larry Gura | Larry Gura | Paul Mitchell | | 677 | 587 | 90 |
| 1976-10-01 | vs CAL | 159 | L 0-2 | 86-73 | 2 | 3,918 | Vida Blue | Frank Tanana | Frank Tanana | Vida Blue | Dick Drago | 677 | 589 | 88 |
| 1976-10-02 | vs CAL | 160 | W 9-8 | 87-73 | 2 | 3,139 | Chris Batton | Paul Hartzell | Rollie Fingers | John Verhoeven | | 686 | 597 | 89 |
| 1976-10-03 | vs CAL | 161 | L 0-1 | 87-74 | 2 | 9,155 | Mike Torrez | Nolan Ryan | Nolan Ryan | Mike Torrez | | 686 | 598 | 88 |