| 1976-04-09 | @ NYN | 1 | L 2-3 | 0-1 | 4 | 17,013 | Steve Rogers | Tom Seaver | Tom Seaver | Steve Rogers | Skip Lockwood | 2 | 3 | -1 |
| 1976-04-10 | @ NYN | 2 | L 0-1 | 0-2 | 5 | 12,035 | Woodie Fryman | Jon Matlack | Jon Matlack | Woodie Fryman | | 2 | 4 | -2 |
| 1976-04-11 | @ NYN | 3 | W 7-6 | 1-2 | 4 | 12,273 | Dan Warthen | Mickey Lolich | Fred Scherman | Mickey Lolich | Dale Murray | 9 | 10 | -1 |
| 1976-04-14 | vs PHI | 4 | L 2-8 | 1-3 | 5 | 21,199 | Steve Rogers | Jim Lonborg | Jim Lonborg | Steve Rogers | | 11 | 18 | -7 |
| 1976-04-15 | vs PHI | 5 | W 8-5 | 2-3 | 4 | 6,375 | Woodie Fryman | Jim Kaat | Woodie Fryman | Jim Kaat | Wayne Granger | 19 | 23 | -4 |
| 1976-04-17 | @ SLN | 6 | L 3-4 | 2-4 | 5 | 10,568 | Clay Kirby | Bob Forsch | Eric Rasmussen | Fred Scherman | | 22 | 27 | -5 |
| 1976-04-18 | @ SLN | 7 | L 1-2 | 2-5 | 6 | 7,121 | Dan Warthen | John Denny | John Denny | Dan Warthen | Mike Wallace | 23 | 29 | -6 |
| 1976-04-19 | @ CHN | 8 | W 4-3 | 3-5 | 5 | 10,210 | Steve Rogers | Bill Bonham | Steve Rogers | Bill Bonham | Wayne Granger | 27 | 32 | -5 |
| 1976-04-21 | @ CHN | 9 | W 12-6 | 4-5 | 4 | 7,277 | Woodie Fryman | Geoff Zahn | Woodie Fryman | Geoff Zahn | | 39 | 38 | 1 |
| 1976-04-22 | @ CHN | 10 | L 4-5 | 4-6 | 5 | 11,355 | Clay Kirby | Rick Reuschel | Oscar Zamora | Dale Murray | | 43 | 43 | 0 |
| 1976-04-23 | vs CIN | 11 | W 5-4 | 5-6 | 5 | 5,306 | Dan Warthen | Gary Nolan | Don Stanhouse | Jack Billingham | | 48 | 47 | 1 |
| 1976-04-24 | vs CIN | 12 | L 4-6 | 5-7 | 5 | 11,190 | Steve Rogers | Pat Zachry | Rawly Eastwick | Don Carrithers | | 52 | 53 | -1 |
| 1976-04-25 | vs CIN | 13 | L 0-7 | 5-8 | 5 | 8,095 | Steve Renko | Don Gullett | Don Gullett | Steve Renko | Pat Darcy | 52 | 60 | -8 |
| 1976-04-28 | vs HOU | 14 | L 4-6 | 6-9 | 6 | 0 | Woodie Fryman | J.R. Richard | J.R. Richard | Woodie Fryman | | 56 | 66 | -10 |
| 1976-04-28 | vs HOU | 15 | W 8-7 | 6-9 | 6 | 5,330 | Clay Kirby | Mike Cosgrove | Don Carrithers | Mike Barlow | | 64 | 73 | -9 |
| 1976-04-29 | vs HOU | 16 | L 1-3 | 6-10 | 6 | 5,873 | Steve Rogers | Larry Dierker | Larry Dierker | Dale Murray | Larry Hardy | 65 | 76 | -11 |
| 1976-04-30 | @ CIN | 17 | L 2-7 | 6-11 | 6 | 20,166 | Dan Warthen | Gary Nolan | Gary Nolan | Dan Warthen | | 67 | 83 | -16 |
| 1976-05-01 | @ CIN | 18 | L 1-6 | 6-12 | 6 | 28,138 | Don Carrithers | Don Gullett | Don Gullett | Don Carrithers | | 68 | 89 | -21 |
| 1976-05-02 | @ CIN | 19 | W 8-4 | 7-12 | 6 | 49,285 | Woodie Fryman | Jack Billingham | Don Stanhouse | Pat Darcy | | 76 | 93 | -17 |
| 1976-05-05 | vs SDN | 20 | L 4-6 | 7-13 | 6 | 6,085 | Steve Rogers | Brent Strom | Brent Strom | Steve Rogers | Butch Metzger | 80 | 99 | -19 |
| 1976-05-06 | vs SDN | 21 | L 1-4 | 7-14 | 6 | 3,606 | Clay Kirby | Dan Spillner | Dan Spillner | Clay Kirby | Butch Metzger | 81 | 103 | -22 |
| 1976-05-08 | vs SFN | 22 | W 7-5 | 8-14 | 6 | 10,112 | Woodie Fryman | John D'Acquisto | Woodie Fryman | John D'Acquisto | Dale Murray | 88 | 108 | -20 |
| 1976-05-09 | vs SFN | 23 | L 2-4 | 9-15 | 6 | 0 | Dan Warthen | John Montefusco | John Montefusco | Dan Warthen | Gary Lavelle | 90 | 112 | -22 |
| 1976-05-09 | vs SFN | 24 | W 8-0 | 9-15 | 6 | 10,496 | Steve Rogers | Greg Minton | Steve Rogers | Greg Minton | | 98 | 112 | -14 |
| 1976-05-11 | @ HOU | 25 | L 3-5 | 9-16 | 6 | 8,706 | Clay Kirby | Joe Niekro | Tom Griffin | Clay Kirby | Ken Forsch | 101 | 117 | -16 |
| 1976-05-12 | @ HOU | 26 | W 7-2 | 10-16 | 6 | 8,665 | Woodie Fryman | J.R. Richard | Woodie Fryman | J.R. Richard | | 108 | 119 | -11 |
| 1976-05-15 | @ ATL | 27 | L 1-3 | 11-17 | 6 | 0 | Steve Rogers | Dick Ruthven | Dick Ruthven | Steve Rogers | | 109 | 122 | -13 |
| 1976-05-15 | @ ATL | 28 | W 6-1 | 11-17 | 6 | 10,306 | Dan Warthen | Phil Niekro | Dan Warthen | Phil Niekro | | 115 | 123 | -8 |
| 1976-05-16 | @ ATL | 29 | W 5-4 | 12-17 | 6 | 6,622 | Clay Kirby | Carl Morton | Fred Scherman | Elias Sosa | Don Stanhouse | 120 | 127 | -7 |
| 1976-05-20 | vs CHN | 30 | W 3-0 | 13-17 | 4 | 5,610 | Woodie Fryman | Ray Burris | Woodie Fryman | Ray Burris | Dale Murray | 123 | 127 | -4 |
| 1976-05-21 | vs NYN | 31 | L 3-4 | 13-18 | 5 | 8,543 | Steve Rogers | Jon Matlack | Skip Lockwood | Dale Murray | Ken Sanders | 126 | 131 | -5 |
| 1976-05-22 | vs NYN | 32 | L 1-4 | 13-19 | 6 | 7,575 | Don Stanhouse | Jerry Koosman | Jerry Koosman | Fred Scherman | Skip Lockwood | 127 | 135 | -8 |
| 1976-05-23 | vs NYN | 33 | W 5-4 | 14-19 | 5 | 22,861 | Don Carrithers | Craig Swan | Chip Lang | Craig Swan | | 132 | 139 | -7 |
| 1976-05-24 | @ PIT | 34 | W 4-2 | 15-19 | 4 | 5,420 | Woodie Fryman | John Candelaria | Woodie Fryman | John Candelaria | Fred Scherman | 136 | 141 | -5 |
| 1976-05-25 | @ PIT | 35 | W 6-3 | 16-19 | 4 | 4,805 | Steve Rogers | Doc Medich | Wayne Granger | Bob Moose | | 142 | 144 | -2 |
| 1976-05-26 | @ PIT | 36 | L 3-6 | 16-20 | 4 | 6,581 | Dan Warthen | Larry Demery | Larry Demery | Dan Warthen | John Candelaria | 145 | 150 | -5 |
| 1976-05-28 | @ PHI | 37 | L 3-10 | 16-21 | 5 | 23,011 | Don Stanhouse | Tom Underwood | Ron Reed | Don Stanhouse | | 148 | 160 | -12 |
| 1976-05-29 | @ PHI | 38 | L 1-6 | 16-22 | 6 | 18,063 | Don Carrithers | Larry Christenson | Larry Christenson | Don Carrithers | Gene Garber | 149 | 166 | -17 |
| 1976-05-30 | @ PHI | 39 | L 1-7 | 16-23 | 6 | 27,090 | Clay Kirby | Jim Lonborg | Jim Lonborg | Clay Kirby | | 150 | 173 | -23 |
| 1976-06-01 | vs SLN | 40 | L 2-6 | 16-24 | 6 | 12,323 | Dan Warthen | Pete Falcone | Pete Falcone | Dan Warthen | | 152 | 179 | -27 |
| 1976-06-02 | vs PIT | 41 | L 2-4 | 16-25 | 6 | 11,337 | Woodie Fryman | Bruce Kison | Bruce Kison | Woodie Fryman | Dave Giusti | 154 | 183 | -29 |
| 1976-06-03 | vs PIT | 42 | W 7-1 | 17-25 | 6 | 7,951 | Don Stanhouse | Jim Rooker | Don Stanhouse | Jim Rooker | | 161 | 184 | -23 |
| 1976-06-04 | vs ATL | 43 | L 0-2 | 17-26 | 6 | 11,085 | Don Carrithers | Andy Messersmith | Andy Messersmith | Don Carrithers | | 161 | 186 | -25 |
| 1976-06-05 | vs ATL | 44 | L 0-8 | 17-27 | 6 | 18,230 | Clay Kirby | Dick Ruthven | Dick Ruthven | Clay Kirby | | 161 | 194 | -33 |
| 1976-06-06 | vs ATL | 45 | L 8-14 | 17-28 | 6 | 12,063 | Dan Warthen | Roger Moret | Adrian Devine | Steve Dunning | | 169 | 208 | -39 |
| 1976-06-08 | @ SFN | 46 | W 9-4 | 18-28 | 6 | 2,424 | Woodie Fryman | Rob Dressler | Woodie Fryman | Rob Dressler | | 178 | 212 | -34 |
| 1976-06-09 | @ SFN | 47 | L 2-6 | 18-29 | 6 | 2,209 | Don Stanhouse | Jim Barr | Jim Barr | Don Stanhouse | Randy Moffitt | 180 | 218 | -38 |
| 1976-06-10 | @ SFN | 48 | W 6-5 | 19-29 | 6 | 2,321 | Don Carrithers | Ed Halicki | Don Carrithers | Ed Halicki | Dale Murray | 186 | 223 | -37 |
| 1976-06-11 | @ LAN | 49 | L 4-7 | 19-30 | 6 | 17,278 | Clay Kirby | Don Sutton | Don Sutton | Clay Kirby | Charlie Hough | 190 | 230 | -40 |
| 1976-06-12 | @ LAN | 50 | L 3-4 | 19-31 | 6 | 22,794 | Dan Warthen | Rick Rhoden | Rick Rhoden | Dan Warthen | | 193 | 234 | -41 |
| 1976-06-13 | @ LAN | 51 | L 3-6 | 19-32 | 6 | 36,497 | Woodie Fryman | Tommy John | Tommy John | Woodie Fryman | | 196 | 240 | -44 |
| 1976-06-14 | @ SDN | 52 | W 3-0 | 20-32 | 6 | 21,774 | Don Stanhouse | Brent Strom | Don Stanhouse | Brent Strom | | 199 | 240 | -41 |
| 1976-06-15 | @ SDN | 53 | L 1-2 | 20-33 | 6 | 9,447 | Don Carrithers | Alan Foster | Alan Foster | Don Carrithers | | 200 | 242 | -42 |
| 1976-06-16 | @ SDN | 54 | L 2-6 | 20-34 | 6 | 13,306 | Dan Warthen | Dave Freisleben | Dave Freisleben | Dan Warthen | | 202 | 248 | -46 |
| 1976-06-18 | vs LAN | 55 | L 5-6 | 20-35 | 6 | 14,623 | Woodie Fryman | Rick Rhoden | Mike Marshall | Dale Murray | Charlie Hough | 207 | 254 | -47 |
| 1976-06-19 | vs LAN | 56 | W 2-1 | 21-35 | 6 | 12,870 | Don Stanhouse | Tommy John | Don Stanhouse | Charlie Hough | | 209 | 255 | -46 |
| 1976-06-20 | vs LAN | 57 | W 5-4 | 22-35 | 6 | 10,194 | Don Carrithers | Burt Hooton | Don Carrithers | Burt Hooton | Dale Murray | 214 | 259 | -45 |
| 1976-06-21 | @ PHI | 58 | L 3-8 | 22-36 | 6 | 26,148 | Dan Warthen | Tom Underwood | Tom Underwood | Dan Warthen | | 217 | 267 | -50 |
| 1976-06-22 | @ PHI | 59 | W 8-3 | 23-36 | 6 | 32,138 | Clay Kirby | Jim Lonborg | Clay Kirby | Jim Lonborg | Dale Murray | 225 | 270 | -45 |
| 1976-06-23 | @ ATL | 60 | L 2-5 | 23-38 | 6 | 0 | Steve Dunning | Andy Messersmith | Andy Messersmith | Steve Dunning | | 227 | 275 | -48 |
| 1976-06-23 | @ ATL | 61 | L 0-3 | 23-38 | 6 | 12,124 | Woodie Fryman | Phil Niekro | Phil Niekro | Woodie Fryman | | 227 | 278 | -51 |
| 1976-06-24 | @ ATL | 62 | L 1-2 | 23-39 | 6 | 7,730 | Don Stanhouse | Dick Ruthven | Dick Ruthven | Don Stanhouse | | 228 | 280 | -52 |
| 1976-06-25 | vs PIT | 63 | L 2-9 | 23-40 | 6 | 6,581 | Don Carrithers | Bruce Kison | Bruce Kison | Don Carrithers | | 230 | 289 | -59 |
| 1976-06-26 | vs PIT | 64 | L 6-7 | 23-41 | 6 | 10,445 | Dan Warthen | Jerry Reuss | Larry Demery | Dale Murray | | 236 | 296 | -60 |
| 1976-06-27 | vs PIT | 65 | W 4-3 | 24-41 | 6 | 12,824 | Woodie Fryman | Doc Medich | Woodie Fryman | Doc Medich | Dale Murray | 240 | 299 | -59 |
| 1976-06-28 | vs PHI | 66 | L 2-6 | 24-42 | 6 | 14,177 | Steve Rogers | Steve Carlton | Steve Carlton | Steve Rogers | | 242 | 305 | -63 |
| 1976-06-29 | vs PHI | 67 | L 1-2 | 24-43 | 6 | 10,939 | Don Stanhouse | Jim Kaat | Gene Garber | Dale Murray | Ron Reed | 243 | 307 | -64 |
| 1976-07-02 | @ SLN | 68 | L 0-3 | 24-44 | 6 | 8,923 | Woodie Fryman | Lynn McGlothen | Lynn McGlothen | Woodie Fryman | | 243 | 310 | -67 |
| 1976-07-03 | @ SLN | 69 | L 0-9 | 24-45 | 6 | 12,659 | Steve Rogers | John Denny | John Denny | Steve Rogers | | 243 | 319 | -76 |
| 1976-07-04 | @ SLN | 70 | W 4-3 | 25-45 | 6 | 13,789 | Don Stanhouse | Pete Falcone | Don Stanhouse | Pete Falcone | Dale Murray | 247 | 322 | -75 |
| 1976-07-05 | vs CIN | 71 | L 2-11 | 25-46 | 6 | 14,331 | Chip Lang | Jack Billingham | Jack Billingham | Chip Lang | | 249 | 333 | -84 |
| 1976-07-06 | vs CIN | 72 | L 7-10 | 25-47 | 6 | 14,026 | Clay Kirby | Pedro Borbon | Rawly Eastwick | Clay Kirby | Don Gullett | 256 | 343 | -87 |
| 1976-07-07 | vs CIN | 73 | L 3-4 | 25-48 | 6 | 7,105 | Steve Rogers | Pat Zachry | Rich Hinton | Steve Rogers | Will McEnaney | 259 | 347 | -88 |
| 1976-07-08 | @ HOU | 74 | L 6-7 | 25-49 | 6 | 6,598 | Woodie Fryman | Mike Cosgrove | Ken Forsch | Steve Dunning | | 265 | 354 | -89 |
| 1976-07-09 | @ HOU | 75 | L 0-6 | 25-50 | 6 | 12,511 | Don Stanhouse | Larry Dierker | Larry Dierker | Don Stanhouse | | 265 | 360 | -95 |
| 1976-07-10 | @ HOU | 76 | L 2-4 | 25-51 | 6 | 14,035 | Clay Kirby | J.R. Richard | J.R. Richard | Clay Kirby | Ken Forsch | 267 | 364 | -97 |
| 1976-07-11 | @ HOU | 77 | L 0-1 | 25-52 | 6 | 11,722 | Steve Rogers | Joaquin Andujar | Joaquin Andujar | Steve Rogers | | 267 | 365 | -98 |
| 1976-07-15 | @ CIN | 78 | W 4-3 | 26-52 | 6 | 25,047 | Steve Rogers | Gary Nolan | Steve Rogers | Will McEnaney | Dale Murray | 271 | 368 | -97 |
| 1976-07-16 | @ CIN | 79 | L 3-4 | 26-53 | 6 | 42,501 | Don Stanhouse | Fred Norman | Rawly Eastwick | Dale Murray | | 274 | 372 | -98 |
| 1976-07-17 | @ CIN | 80 | L 1-4 | 26-54 | 6 | 51,049 | Woodie Fryman | Santo Alcala | Santo Alcala | Woodie Fryman | | 275 | 376 | -101 |
| 1976-07-18 | vs HOU | 81 | L 6-7 | 26-56 | 6 | 0 | Clay Kirby | Joe Niekro | Ken Forsch | Dale Murray | | 281 | 383 | -102 |
| 1976-07-18 | vs HOU | 82 | L 1-14 | 26-56 | 6 | 11,641 | Steve Dunning | Dan Larson | Dan Larson | Steve Dunning | | 282 | 397 | -115 |
| 1976-07-19 | vs HOU | 83 | L 1-3 | 26-57 | 6 | 7,563 | Steve Rogers | J.R. Richard | J.R. Richard | Steve Rogers | | 283 | 400 | -117 |
| 1976-07-20 | vs ATL | 84 | W 4-3 | 27-57 | 6 | 10,423 | Don Carrithers | Andy Messersmith | Don Carrithers | Andy Messersmith | | 287 | 403 | -116 |
| 1976-07-21 | vs ATL | 85 | W 4-3 | 28-57 | 6 | 10,171 | Don Stanhouse | Dick Ruthven | Dale Murray | Bruce Dal Canton | | 291 | 406 | -115 |
| 1976-07-22 | vs ATL | 86 | L 1-7 | 28-58 | 6 | 11,040 | Woodie Fryman | Carl Morton | Carl Morton | Woodie Fryman | Bruce Dal Canton | 292 | 413 | -121 |
| 1976-07-23 | vs NYN | 87 | W 3-2 | 29-58 | 6 | 11,134 | Steve Rogers | Tom Seaver | Dale Murray | Skip Lockwood | | 295 | 415 | -120 |
| 1976-07-24 | vs NYN | 88 | L 4-10 | 29-59 | 6 | 14,198 | Clay Kirby | Mickey Lolich | Mickey Lolich | Clay Kirby | Bob Apodaca | 299 | 425 | -126 |
| 1976-07-25 | vs NYN | 89 | W 2-1 | 30-59 | 6 | 13,102 | Don Carrithers | Jerry Koosman | Don Carrithers | Jerry Koosman | | 301 | 426 | -125 |
| 1976-07-26 | @ CHN | 90 | W 2-1 | 32-59 | 6 | 0 | Don Stanhouse | Steve Stone | Don Stanhouse | Steve Stone | | 303 | 427 | -124 |
| 1976-07-26 | @ CHN | 91 | W 3-1 | 32-59 | 6 | 12,172 | Steve Dunning | Steve Renko | Steve Dunning | Steve Renko | Dale Murray | 306 | 428 | -122 |
| 1976-07-27 | @ CHN | 92 | L 0-5 | 32-60 | 6 | 11,919 | Steve Rogers | Ray Burris | Ray Burris | Steve Rogers | | 306 | 433 | -127 |
| 1976-07-28 | @ SLN | 93 | W 3-0 | 33-60 | 6 | 16,139 | Woodie Fryman | Eric Rasmussen | Woodie Fryman | Eric Rasmussen | Dale Murray | 309 | 433 | -124 |
| 1976-07-30 | @ PIT | 94 | L 3-4 | 33-61 | 6 | 12,774 | Don Carrithers | John Candelaria | Kent Tekulve | Joe Kerrigan | | 312 | 437 | -125 |
| 1976-07-31 | @ PIT | 95 | W 7-6 | 34-61 | 6 | 10,981 | Don Stanhouse | Jerry Reuss | Dale Murray | Bob Moose | | 319 | 443 | -124 |
| 1976-08-01 | @ PIT | 96 | W 2-0 | 35-61 | 6 | 17,150 | Steve Rogers | Bruce Kison | Steve Rogers | Bruce Kison | | 321 | 443 | -122 |
| 1976-08-02 | @ NYN | 97 | W 5-4 | 36-61 | 6 | 53,523 | Woodie Fryman | Tom Seaver | Chuck Taylor | Skip Lockwood | Joe Kerrigan | 326 | 447 | -121 |
| 1976-08-03 | @ NYN | 98 | L 8-9 | 36-62 | 6 | 12,245 | Clay Kirby | Mickey Lolich | Bob Apodaca | Joe Kerrigan | | 334 | 456 | -122 |
| 1976-08-04 | @ NYN | 99 | L 0-4 | 36-63 | 6 | 15,016 | Don Carrithers | Jerry Koosman | Jerry Koosman | Don Carrithers | | 334 | 460 | -126 |
| 1976-08-05 | vs CHN | 100 | L 3-4 | 36-64 | 6 | 10,333 | Don Stanhouse | Ray Burris | Ray Burris | Don Stanhouse | Bruce Sutter | 337 | 464 | -127 |
| 1976-08-06 | vs CHN | 101 | L 5-6 | 36-66 | 6 | 0 | Don Carrithers | Bill Bonham | Paul Reuschel | Chuck Taylor | | 342 | 470 | -128 |
| 1976-08-06 | vs CHN | 102 | L 0-1 | 36-66 | 6 | 13,145 | Woodie Fryman | Steve Stone | Steve Stone | Joe Kerrigan | | 342 | 471 | -129 |
| 1976-08-07 | vs CHN | 103 | L 3-4 | 37-67 | 6 | 0 | Steve Rogers | Rick Reuschel | Darold Knowles | Joe Kerrigan | | 345 | 475 | -130 |
| 1976-08-07 | vs CHN | 104 | W 7-2 | 37-67 | 6 | 10,106 | Steve Dunning | Oscar Zamora | Steve Dunning | Oscar Zamora | | 352 | 477 | -125 |
| 1976-08-08 | vs CHN | 105 | L 1-7 | 37-68 | 6 | 12,598 | Chip Lang | Steve Renko | Steve Renko | Chip Lang | | 353 | 484 | -131 |
| 1976-08-09 | vs SFN | 106 | W 2-1 | 38-68 | 6 | 7,103 | Don Stanhouse | Jim Barr | Don Stanhouse | Jim Barr | | 355 | 485 | -130 |
| 1976-08-10 | vs SFN | 107 | W 3-2 | 39-68 | 6 | 10,775 | Don Carrithers | Rob Dressler | Don Carrithers | Dave Heaverlo | Steve Rogers | 358 | 487 | -129 |
| 1976-08-11 | vs SFN | 108 | W 9-3 | 40-68 | 6 | 16,490 | Woodie Fryman | John D'Acquisto | Woodie Fryman | John D'Acquisto | | 367 | 490 | -123 |
| 1976-08-13 | vs SDN | 109 | W 6-0 | 41-69 | 6 | 0 | Steve Rogers | Dave Freisleben | Steve Rogers | Dave Freisleben | | 373 | 490 | -117 |
| 1976-08-13 | vs SDN | 110 | L 3-4 | 41-69 | 6 | 11,069 | Steve Dunning | Brent Strom | Brent Strom | Steve Dunning | Butch Metzger | 376 | 494 | -118 |
| 1976-08-14 | vs SDN | 111 | L 2-7 | 41-70 | 6 | 14,889 | Don Stanhouse | Randy Jones | Randy Jones | Don Stanhouse | | 378 | 501 | -123 |
| 1976-08-15 | vs SDN | 112 | L 1-6 | 41-71 | 6 | 10,242 | Don Carrithers | Tom Griffin | Tom Griffin | Don Carrithers | | 379 | 507 | -128 |
| 1976-08-17 | @ PHI | 113 | L 3-11 | 41-72 | 6 | 27,188 | Steve Rogers | Tom Underwood | Tom Underwood | Steve Rogers | | 382 | 518 | -136 |
| 1976-08-18 | @ PHI | 114 | L 4-5 | 41-73 | 6 | 28,483 | Don Stanhouse | Jim Lonborg | Jim Lonborg | Don Stanhouse | Ron Reed | 386 | 523 | -137 |
| 1976-08-20 | @ SFN | 115 | L 3-6 | 41-74 | 6 | 2,319 | Don Carrithers | Ed Halicki | Ed Halicki | Don Carrithers | Randy Moffitt | 389 | 529 | -140 |
| 1976-08-21 | @ SFN | 116 | L 4-5 | 41-75 | 6 | 3,647 | Steve Rogers | John D'Acquisto | Rob Dressler | Chip Lang | | 393 | 534 | -141 |
| 1976-08-22 | @ SFN | 117 | L 3-4 | 41-76 | 6 | 5,126 | Woodie Fryman | John Montefusco | Gary Lavelle | Chuck Taylor | | 396 | 538 | -142 |
| 1976-08-23 | @ LAN | 118 | L 3-6 | 41-77 | 6 | 16,508 | Don Stanhouse | Tommy John | Tommy John | Don Stanhouse | | 399 | 544 | -145 |
| 1976-08-24 | @ LAN | 119 | L 0-6 | 41-78 | 6 | 18,846 | Don Carrithers | Burt Hooton | Burt Hooton | Don Carrithers | | 399 | 550 | -151 |
| 1976-08-25 | @ LAN | 120 | L 1-3 | 41-79 | 6 | 18,738 | Steve Rogers | Doug Rau | Doug Rau | Steve Rogers | | 400 | 553 | -153 |
| 1976-08-27 | @ SDN | 121 | L 0-2 | 41-80 | 6 | 21,301 | Woodie Fryman | Randy Jones | Randy Jones | Woodie Fryman | | 400 | 555 | -155 |
| 1976-08-28 | @ SDN | 122 | W 7-4 | 42-80 | 6 | 10,545 | Don Stanhouse | Tom Griffin | Dale Murray | Butch Metzger | | 407 | 559 | -152 |
| 1976-08-29 | @ SDN | 123 | W 3-0 | 43-80 | 6 | 7,563 | Steve Rogers | Rick Sawyer | Steve Rogers | Rick Sawyer | | 410 | 559 | -149 |
| 1976-08-31 | vs LAN | 124 | L 1-5 | 43-81 | 6 | 9,369 | Woodie Fryman | Doug Rau | Doug Rau | Woodie Fryman | Charlie Hough | 411 | 564 | -153 |
| 1976-09-02 | vs LAN | 125 | L 1-2 | 43-83 | 6 | 0 | Steve Rogers | Don Sutton | Don Sutton | Steve Rogers | Charlie Hough | 412 | 566 | -154 |
| 1976-09-02 | vs LAN | 126 | L 3-5 | 43-83 | 6 | 7,181 | Steve Dunning | Rick Rhoden | Elias Sosa | Steve Dunning | Charlie Hough | 415 | 571 | -156 |
| 1976-09-03 | vs PIT | 127 | L 7-9 | 43-85 | 6 | 0 | Don Stanhouse | Jim Rooker | Jim Rooker | Don Stanhouse | Kent Tekulve | 422 | 580 | -158 |
| 1976-09-03 | vs PIT | 128 | L 2-7 | 43-85 | 6 | 6,342 | Don Carrithers | John Candelaria | John Candelaria | Don Carrithers | | 424 | 587 | -163 |
| 1976-09-04 | vs PIT | 129 | L 3-5 | 43-86 | 6 | 3,290 | Dennis Blair | Doc Medich | Dave Giusti | Dale Murray | Kent Tekulve | 427 | 592 | -165 |
| 1976-09-05 | vs PIT | 130 | W 1-0 | 44-86 | 6 | 6,180 | Woodie Fryman | Jerry Reuss | Woodie Fryman | Jerry Reuss | | 428 | 592 | -164 |
| 1976-09-06 | vs SLN | 131 | L 1-3 | 45-87 | 6 | 0 | Steve Rogers | Pete Falcone | Pete Falcone | Steve Rogers | | 429 | 595 | -166 |
| 1976-09-06 | vs SLN | 132 | W 3-2 | 45-87 | 6 | 6,509 | Steve Dunning | Lerrin LaGrow | Chuck Taylor | John Curtis | | 432 | 597 | -165 |
| 1976-09-07 | vs SLN | 133 | L 4-7 | 45-88 | 6 | 2,107 | Don Stanhouse | Eric Rasmussen | Mike Wallace | Chuck Taylor | Bill Greif | 436 | 604 | -168 |
| 1976-09-08 | @ SLN | 134 | W 7-5 | 47-88 | 6 | 0 | Dennis Blair | Bob Forsch | Joe Kerrigan | John Curtis | Dale Murray | 443 | 609 | -166 |
| 1976-09-08 | @ SLN | 135 | W 8-7 | 47-88 | 6 | 6,945 | Gerry Hannahs | Eddie Solomon | Joe Kerrigan | Tom Walker | Woodie Fryman | 451 | 616 | -165 |
| 1976-09-09 | @ SLN | 136 | L 1-6 | 47-89 | 6 | 4,595 | Don Carrithers | Lynn McGlothen | Lynn McGlothen | Don Carrithers | | 452 | 622 | -170 |
| 1976-09-10 | @ PIT | 137 | W 4-2 | 48-89 | 6 | 12,032 | Woodie Fryman | John Candelaria | Woodie Fryman | John Candelaria | | 456 | 624 | -168 |
| 1976-09-11 | @ PIT | 138 | L 3-4 | 48-90 | 6 | 7,509 | Steve Rogers | Jerry Reuss | Jerry Reuss | Steve Rogers | Kent Tekulve | 459 | 628 | -169 |
| 1976-09-12 | @ PIT | 139 | L 1-6 | 48-91 | 6 | 12,765 | Don Stanhouse | Bruce Kison | Bruce Kison | Don Stanhouse | Kent Tekulve | 460 | 634 | -174 |
| 1976-09-13 | @ PHI | 140 | L 2-7 | 48-92 | 6 | 20,114 | Dennis Blair | Steve Carlton | Steve Carlton | Dennis Blair | Gene Garber | 462 | 641 | -179 |
| 1976-09-14 | @ PHI | 141 | L 2-3 | 48-93 | 6 | 23,812 | Woodie Fryman | Jim Lonborg | Jim Lonborg | Woodie Fryman | Ron Reed | 464 | 644 | -180 |
| 1976-09-15 | vs CHN | 142 | L 0-2 | 48-94 | 6 | 2,782 | Steve Rogers | Ray Burris | Ray Burris | Steve Rogers | | 464 | 646 | -182 |
| 1976-09-16 | vs CHN | 143 | W 4-3 | 49-94 | 6 | 2,877 | Larry Landreth | Steve Renko | Larry Landreth | Steve Renko | Dale Murray | 468 | 649 | -181 |
| 1976-09-17 | vs SLN | 144 | W 9-5 | 50-94 | 6 | 2,323 | Gerry Hannahs | Eric Rasmussen | Gerry Hannahs | Eric Rasmussen | | 477 | 654 | -177 |
| 1976-09-18 | vs SLN | 145 | L 1-4 | 50-96 | 6 | 0 | Don Stanhouse | Bob Forsch | Bob Forsch | Don Stanhouse | Tom Walker | 478 | 658 | -180 |
| 1976-09-18 | vs SLN | 146 | L 4-7 | 50-96 | 6 | 6,759 | Joe Keener | Eddie Solomon | Eddie Solomon | Joe Keener | Tom Walker | 482 | 665 | -183 |
| 1976-09-19 | vs SLN | 147 | L 7-9 | 51-97 | 6 | 0 | Steve Rogers | Lynn McGlothen | Tom Walker | Joe Kerrigan | Bill Greif | 489 | 674 | -185 |
| 1976-09-19 | vs SLN | 148 | W 1-0 | 51-97 | 6 | 14,687 | Woodie Fryman | Lerrin LaGrow | Woodie Fryman | Lerrin LaGrow | | 490 | 674 | -184 |
| 1976-09-21 | vs NYN | 149 | W 4-0 | 52-97 | 6 | 3,909 | Dan Warthen | Jerry Koosman | Dan Warthen | Jerry Koosman | | 494 | 674 | -180 |
| 1976-09-22 | vs NYN | 150 | L 2-4 | 52-98 | 6 | 3,229 | Larry Landreth | Jon Matlack | Jon Matlack | Larry Landreth | Skip Lockwood | 496 | 678 | -182 |
| 1976-09-24 | vs PHI | 151 | L 3-9 | 53-99 | 6 | 0 | Steve Rogers | Larry Christenson | Larry Christenson | Steve Rogers | Gene Garber | 499 | 687 | -188 |
| 1976-09-24 | vs PHI | 152 | W 3-2 | 53-99 | 6 | 4,510 | Don Stanhouse | Jim Kaat | Don Stanhouse | Jim Kaat | | 502 | 689 | -187 |
| 1976-09-25 | vs PHI | 153 | L 5-6 | 53-100 | 6 | 5,096 | Woodie Fryman | Tom Underwood | Wayne Twitchell | Woodie Fryman | Gene Garber | 507 | 695 | -188 |
| 1976-09-26 | vs PHI | 154 | L 1-4 | 53-102 | 6 | 0 | Dan Warthen | Jim Lonborg | Jim Lonborg | Dan Warthen | | 508 | 699 | -191 |
| 1976-09-26 | vs PHI | 155 | L 1-2 | 53-102 | 6 | 14,166 | Dennis Blair | Ron Reed | Ron Schueler | Dennis Blair | | 509 | 701 | -192 |
| 1976-09-27 | @ NYN | 156 | L 3-10 | 53-103 | 6 | 2,929 | Larry Landreth | Jon Matlack | Jon Matlack | Larry Landreth | | 512 | 711 | -199 |
| 1976-09-28 | @ NYN | 157 | L 4-5 | 54-104 | 6 | 0 | Joe Keener | Nino Espinosa | Skip Lockwood | Joe Kerrigan | | 516 | 716 | -200 |
| 1976-09-28 | @ NYN | 158 | W 4-2 | 54-104 | 6 | 6,372 | Gerry Hannahs | Bob Myrick | Gerry Hannahs | Bob Myrick | Woodie Fryman | 520 | 718 | -198 |
| 1976-09-29 | @ NYN | 159 | W 7-2 | 55-104 | 6 | 27,903 | Steve Rogers | Tom Seaver | Steve Rogers | Tom Seaver | | 527 | 720 | -193 |
| 1976-10-01 | @ CHN | 160 | L 1-3 | 55-105 | 6 | 2,005 | Don Stanhouse | Bill Bonham | Bill Bonham | Don Stanhouse | Bruce Sutter | 528 | 723 | -195 |
| 1976-10-02 | @ CHN | 161 | L 1-3 | 55-106 | 6 | 6,532 | Dan Warthen | Ray Burris | Ray Burris | Dan Warthen | | 529 | 726 | -197 |
| 1976-10-03 | @ CHN | 162 | L 2-8 | 55-107 | 6 | 9,486 | Woodie Fryman | Rick Reuschel | Rick Reuschel | Woodie Fryman | | 531 | 734 | -203 |