| 1976-04-09 | @ TEX | 1 | L 1-2 | 0-1 | 5 | 28,947 | Bert Blyleven | Gaylord Perry | Gaylord Perry | Bill Campbell | | 1 | 2 | -1 |
| 1976-04-10 | @ TEX | 2 | L 1-4 | 0-2 | 5 | 13,005 | Joe Decker | Jim Umbarger | Jim Umbarger | Joe Decker | | 2 | 6 | -4 |
| 1976-04-11 | @ TEX | 3 | W 4-3 | 1-2 | 4 | 11,781 | Dave Goltz | Bill Singer | Bill Campbell | Jeff Terpko | | 6 | 9 | -3 |
| 1976-04-13 | vs CHA | 4 | L 1-4 | 1-3 | 5 | 20,732 | Bert Blyleven | Rich Gossage | Rich Gossage | Bert Blyleven | | 7 | 13 | -6 |
| 1976-04-14 | vs CHA | 5 | W 6-2 | 2-3 | 4 | 4,046 | Joe Decker | Wilbur Wood | Joe Decker | Wilbur Wood | Bill Campbell | 13 | 15 | -2 |
| 1976-04-15 | @ NYA | 6 | L 4-11 | 2-4 | 4 | 52,613 | Dave Goltz | Rudy May | Dick Tidrow | Vic Albury | Sparky Lyle | 17 | 26 | -9 |
| 1976-04-17 | @ NYA | 7 | L 0-10 | 2-5 | 6 | 26,881 | Jim Hughes | Ed Figueroa | Ed Figueroa | Jim Hughes | | 17 | 36 | -19 |
| 1976-04-18 | @ NYA | 8 | W 5-4 | 3-5 | 5 | 25,330 | Bert Blyleven | Catfish Hunter | Bert Blyleven | Catfish Hunter | Bill Campbell | 22 | 40 | -18 |
| 1976-04-19 | @ BOS | 9 | L 0-2 | 3-6 | 6 | 34,158 | Joe Decker | Fergie Jenkins | Fergie Jenkins | Joe Decker | | 22 | 42 | -20 |
| 1976-04-20 | @ BOS | 10 | L 3-12 | 3-7 | 6 | 22,147 | Dave Goltz | Rick Wise | Rick Wise | Dave Goltz | | 25 | 54 | -29 |
| 1976-04-24 | vs BAL | 11 | W 2-1 | 4-7 | 6 | 4,222 | Bert Blyleven | Ken Holtzman | Bill Campbell | Grant Jackson | | 27 | 55 | -28 |
| 1976-04-25 | vs BAL | 12 | W 7-2 | 5-7 | 5 | 5,657 | Joe Decker | Jim Palmer | Tom Burgmeier | Jim Palmer | | 34 | 57 | -23 |
| 1976-04-27 | vs CLE | 13 | L 5-7 | 5-8 | 5 | 3,424 | Dave Goltz | Jim Bibby | Jackie Brown | Dave Goltz | Dave LaRoche | 39 | 64 | -25 |
| 1976-04-28 | vs CLE | 14 | L 0-9 | 5-9 | 5 | 3,094 | Bert Blyleven | Dennis Eckersley | Dennis Eckersley | Bert Blyleven | Don Hood | 39 | 73 | -34 |
| 1976-05-01 | vs MIL | 15 | W 9-5 | 6-9 | 4 | 6,874 | Joe Decker | Pete Broberg | Bill Campbell | Pete Broberg | | 48 | 78 | -30 |
| 1976-05-04 | @ DET | 16 | W 5-4 | 7-9 | 4 | 8,818 | Dave Goltz | Joe Coleman | Vic Albury | Bill Laxton | Steve Luebber | 53 | 82 | -29 |
| 1976-05-05 | @ DET | 17 | W 8-2 | 8-9 | 4 | 8,317 | Bert Blyleven | Dave Roberts | Bert Blyleven | Dave Roberts | | 61 | 84 | -23 |
| 1976-05-07 | @ MIL | 18 | L 3-4 | 8-10 | 4 | 6,114 | Jim Hughes | Jim Slaton | Jim Slaton | Jim Hughes | Eduardo Rodriguez | 64 | 88 | -24 |
| 1976-05-08 | @ MIL | 19 | W 13-2 | 9-10 | 3 | 21,619 | Joe Decker | Bill Travers | Joe Decker | Bill Travers | | 77 | 90 | -13 |
| 1976-05-09 | @ MIL | 20 | W 6-4 | 10-10 | 3 | 17,604 | Dave Goltz | Pete Broberg | Bill Campbell | Eduardo Rodriguez | | 83 | 94 | -11 |
| 1976-05-10 | @ KCA | 21 | W 5-4 | 11-10 | 3 | 12,526 | Bert Blyleven | Paul Splittorff | Tom Burgmeier | Marty Pattin | Steve Luebber | 88 | 98 | -10 |
| 1976-05-11 | @ KCA | 22 | L 3-6 | 11-11 | 4 | 9,652 | Jim Hughes | Doug Bird | Doug Bird | Steve Luebber | Mark Littell | 91 | 104 | -13 |
| 1976-05-12 | @ KCA | 23 | L 5-17 | 11-12 | 4 | 9,601 | Joe Decker | Steve Busby | Marty Pattin | Joe Decker | | 96 | 121 | -25 |
| 1976-05-14 | @ CAL | 24 | W 6-4 | 12-12 | 3 | 11,522 | Dave Goltz | Nolan Ryan | Dave Goltz | Paul Hartzell | | 102 | 125 | -23 |
| 1976-05-15 | @ CAL | 25 | W 5-2 | 14-12 | 3 | 0 | Bert Blyleven | Gary Ross | Bert Blyleven | Gary Ross | | 107 | 127 | -20 |
| 1976-05-15 | @ CAL | 26 | W 15-5 | 14-12 | 3 | 31,535 | Pete Redfern | Sid Monge | Pete Redfern | Sid Monge | Bill Campbell | 122 | 132 | -10 |
| 1976-05-16 | @ CAL | 27 | L 1-5 | 14-13 | 3 | 9,522 | Jim Hughes | Don Kirkwood | Don Kirkwood | Jim Hughes | | 123 | 137 | -14 |
| 1976-05-17 | vs OAK | 28 | W 5-4 | 15-13 | 3 | 8,034 | Joe Decker | Mike Norris | Bill Campbell | Jim Todd | | 128 | 141 | -13 |
| 1976-05-18 | vs OAK | 29 | W 4-3 | 16-13 | 3 | 6,600 | Dave Goltz | Stan Bahnsen | Dave Goltz | Jim Todd | | 132 | 144 | -12 |
| 1976-05-19 | @ CHA | 30 | L 1-4 | 16-14 | 3 | 7,136 | Bert Blyleven | Pete Vuckovich | Pete Vuckovich | Bert Blyleven | Dave Hamilton | 133 | 148 | -15 |
| 1976-05-20 | @ CHA | 31 | L 2-3 | 16-15 | 3 | 6,999 | Pete Redfern | Rich Gossage | Rich Gossage | Pete Redfern | | 135 | 151 | -16 |
| 1976-05-21 | vs KCA | 32 | L 1-5 | 16-16 | 3 | 8,619 | Jim Hughes | Dennis Leonard | Dennis Leonard | Jim Hughes | | 136 | 156 | -20 |
| 1976-05-22 | vs KCA | 33 | W 5-3 | 17-16 | 3 | 6,812 | Dave Goltz | Al Fitzmorris | Dave Goltz | Al Fitzmorris | | 141 | 159 | -18 |
| 1976-05-23 | vs KCA | 34 | W 3-1 | 18-16 | 3 | 24,716 | Bert Blyleven | Paul Splittorff | Bert Blyleven | Paul Splittorff | Bill Campbell | 144 | 160 | -16 |
| 1976-05-24 | @ OAK | 35 | L 7-12 | 18-17 | 4 | 13,624 | Steve Luebber | Dick Bosman | Jim Todd | Bill Campbell | | 151 | 172 | -21 |
| 1976-05-25 | @ OAK | 36 | L 1-6 | 18-18 | 4 | 1,960 | Jim Hughes | Vida Blue | Vida Blue | Jim Hughes | | 152 | 178 | -26 |
| 1976-05-26 | @ OAK | 37 | W 6-1 | 19-18 | 4 | 2,740 | Dave Goltz | Paul Mitchell | Dave Goltz | Paul Mitchell | | 158 | 179 | -21 |
| 1976-05-27 | @ OAK | 38 | L 3-5 | 19-19 | 4 | 3,720 | Bert Blyleven | Mike Torrez | Mike Torrez | Bert Blyleven | Rollie Fingers | 161 | 184 | -23 |
| 1976-05-28 | vs TEX | 39 | L 0-4 | 19-20 | 4 | 4,241 | Steve Luebber | Jim Umbarger | Jim Umbarger | Steve Luebber | | 161 | 188 | -27 |
| 1976-05-29 | vs TEX | 40 | W 5-1 | 20-20 | 4 | 6,112 | Jim Hughes | Steve Hargan | Jim Hughes | Steve Hargan | | 166 | 189 | -23 |
| 1976-05-30 | vs TEX | 41 | W 4-3 | 21-20 | 4 | 8,998 | Dave Goltz | Gaylord Perry | Dave Goltz | Steve Foucault | | 170 | 192 | -22 |
| 1976-05-31 | vs CAL | 42 | L 2-3 | 21-21 | 4 | 8,379 | Bert Blyleven | Frank Tanana | Frank Tanana | Bert Blyleven | | 172 | 195 | -23 |
| 1976-06-01 | vs CAL | 43 | L 4-6 | 21-22 | 4 | 4,907 | Pete Redfern | Nolan Ryan | Nolan Ryan | Pete Redfern | | 176 | 201 | -25 |
| 1976-06-02 | vs CAL | 44 | L 2-5 | 21-23 | 4 | 5,586 | Jim Hughes | Gary Ross | Gary Ross | Jim Hughes | Mickey Scott | 178 | 206 | -28 |
| 1976-06-04 | @ BAL | 45 | W 8-6 | 22-23 | 4 | 35,111 | Dave Goltz | Doyle Alexander | Bill Campbell | Mike Flanagan | | 186 | 212 | -26 |
| 1976-06-05 | @ BAL | 46 | L 1-5 | 22-24 | 4 | 7,673 | Joe Decker | Ken Holtzman | Ken Holtzman | Joe Decker | | 187 | 217 | -30 |
| 1976-06-06 | @ BAL | 47 | W 3-2 | 24-24 | 4 | 0 | Bill Singer | Jim Palmer | Bill Singer | Jim Palmer | | 190 | 219 | -29 |
| 1976-06-06 | @ BAL | 48 | W 11-6 | 24-24 | 4 | 19,046 | Jim Hughes | Mike Cuellar | Jim Hughes | Mike Cuellar | Bill Campbell | 201 | 225 | -24 |
| 1976-06-07 | @ CLE | 49 | W 7-2 | 25-24 | 4 | 5,919 | Dave Goltz | Rick Waits | Dave Goltz | Rick Waits | | 208 | 227 | -19 |
| 1976-06-08 | @ CLE | 50 | W 3-1 | 26-24 | 4 | 6,581 | Pete Redfern | Dennis Eckersley | Bill Campbell | Dennis Eckersley | | 211 | 228 | -17 |
| 1976-06-09 | @ CLE | 51 | L 1-4 | 26-25 | 4 | 5,361 | Joe Decker | Pat Dobson | Pat Dobson | Joe Decker | | 212 | 232 | -20 |
| 1976-06-11 | vs BOS | 52 | W 10-4 | 27-25 | 4 | 15,766 | Bill Singer | Dick Pole | Tom Burgmeier | Dick Pole | | 222 | 236 | -14 |
| 1976-06-12 | vs BOS | 53 | L 2-5 | 27-26 | 4 | 10,812 | Dave Goltz | Luis Tiant | Luis Tiant | Dave Goltz | | 224 | 241 | -17 |
| 1976-06-13 | vs BOS | 54 | L 2-10 | 27-27 | 4 | 22,146 | Jim Hughes | Rick Jones | Rick Jones | Jim Hughes | | 226 | 251 | -25 |
| 1976-06-14 | vs BOS | 55 | L 0-5 | 27-28 | 4 | 6,820 | Joe Decker | Rick Wise | Rick Wise | Joe Decker | | 226 | 256 | -30 |
| 1976-06-15 | vs NYA | 56 | L 2-4 | 27-29 | 4 | 9,772 | Pete Redfern | Dock Ellis | Dock Ellis | Pete Redfern | Sparky Lyle | 228 | 260 | -32 |
| 1976-06-16 | vs NYA | 57 | L 4-9 | 27-30 | 5 | 8,801 | Bill Singer | Ed Figueroa | Ed Figueroa | Bill Singer | | 232 | 269 | -37 |
| 1976-06-17 | vs DET | 58 | W 4-0 | 28-30 | 3 | 5,361 | Dave Goltz | Vern Ruhle | Dave Goltz | Vern Ruhle | | 236 | 269 | -33 |
| 1976-06-18 | vs DET | 59 | L 2-4 | 28-31 | 3 | 6,215 | Jim Hughes | Dave Roberts | Dave Roberts | Jim Hughes | | 238 | 273 | -35 |
| 1976-06-19 | vs DET | 60 | W 6-4 | 29-31 | 3 | 6,835 | Pete Redfern | Frank MacCormack | Pete Redfern | Frank MacCormack | Bill Campbell | 244 | 277 | -33 |
| 1976-06-20 | vs DET | 61 | L 3-7 | 29-32 | 4 | 11,916 | Bill Singer | Mark Fidrych | Mark Fidrych | Bill Singer | John Hiller | 247 | 284 | -37 |
| 1976-06-21 | @ CAL | 62 | L 1-2 | 29-33 | 4 | 19,498 | Dave Goltz | Gary Ross | Gary Ross | Dave Goltz | | 248 | 286 | -38 |
| 1976-06-22 | @ CAL | 63 | W 10-6 | 30-33 | 4 | 6,846 | Jim Hughes | Don Kirkwood | Jim Hughes | Don Kirkwood | | 258 | 292 | -34 |
| 1976-06-23 | vs CHA | 64 | L 3-4 | 30-35 | 5 | 0 | Joe Decker | Bart Johnson | Bart Johnson | Joe Decker | Terry Forster | 261 | 296 | -35 |
| 1976-06-23 | vs CHA | 65 | L 5-9 | 30-35 | 5 | 9,540 | Pete Redfern | Chris Knapp | Pete Vuckovich | Pete Redfern | Ken Brett | 266 | 305 | -39 |
| 1976-06-24 | vs CHA | 66 | W 4-2 | 31-35 | 5 | 12,790 | Bill Singer | Rich Gossage | Bill Singer | Rich Gossage | | 270 | 307 | -37 |
| 1976-06-25 | @ OAK | 67 | L 2-5 | 31-36 | 5 | 5,100 | Dave Goltz | Mike Torrez | Paul Lindblad | Dave Goltz | | 272 | 312 | -40 |
| 1976-06-26 | @ OAK | 68 | W 11-3 | 32-36 | 5 | 4,729 | Jim Hughes | Paul Mitchell | Jim Hughes | Paul Mitchell | | 283 | 315 | -32 |
| 1976-06-27 | @ OAK | 69 | L 3-5 | 32-37 | 5 | 4,798 | Pete Redfern | Dick Bosman | Dick Bosman | Pete Redfern | Rollie Fingers | 286 | 320 | -34 |
| 1976-06-28 | vs KCA | 70 | W 4-3 | 33-37 | 5 | 6,170 | Bill Singer | Dennis Leonard | Bill Campbell | Mark Littell | | 290 | 323 | -33 |
| 1976-06-29 | vs KCA | 71 | L 0-1 | 33-38 | 5 | 6,201 | Dave Goltz | Al Fitzmorris | Al Fitzmorris | Dave Goltz | | 290 | 324 | -34 |
| 1976-06-30 | vs KCA | 72 | L 2-4 | 33-39 | 5 | 7,471 | Eddie Bane | Paul Splittorff | Paul Splittorff | Eddie Bane | | 292 | 328 | -36 |
| 1976-07-02 | vs CAL | 73 | W 6-5 | 34-39 | 5 | 6,235 | Jim Hughes | Don Kirkwood | Vic Albury | Andy Hassler | | 298 | 333 | -35 |
| 1976-07-03 | vs CAL | 74 | W 2-0 | 35-39 | 4 | 6,506 | Bill Singer | Nolan Ryan | Bill Singer | Nolan Ryan | | 300 | 333 | -33 |
| 1976-07-04 | vs CAL | 75 | L 3-5 | 36-40 | 4 | 0 | Dave Goltz | Frank Tanana | Frank Tanana | Dave Goltz | | 303 | 338 | -35 |
| 1976-07-04 | vs CAL | 76 | W 9-5 | 36-40 | 4 | 21,565 | Pete Redfern | Paul Hartzell | Bill Campbell | Dick Drago | | 312 | 343 | -31 |
| 1976-07-05 | @ MIL | 77 | L 2-3 | 36-41 | 4 | 8,074 | Eddie Bane | Bill Travers | Bill Travers | Eddie Bane | | 314 | 346 | -32 |
| 1976-07-06 | @ MIL | 78 | L 2-6 | 36-42 | 4 | 7,383 | Jim Hughes | Jim Slaton | Jim Slaton | Jim Hughes | Danny Frisella | 316 | 352 | -36 |
| 1976-07-07 | @ MIL | 79 | W 8-2 | 37-42 | 4 | 8,160 | Bill Singer | Jerry Augustine | Bill Singer | Jerry Augustine | | 324 | 354 | -30 |
| 1976-07-08 | @ BOS | 80 | L 4-8 | 37-43 | 4 | 25,970 | Dave Goltz | Rick Jones | Rick Jones | Dave Goltz | Reggie Cleveland | 328 | 362 | -34 |
| 1976-07-09 | @ BOS | 81 | W 8-6 | 38-43 | 4 | 29,917 | Pete Redfern | Rick Wise | Bill Campbell | Rick Wise | | 336 | 368 | -32 |
| 1976-07-10 | @ BOS | 82 | W 4-2 | 39-43 | 4 | 28,347 | Eddie Bane | Luis Tiant | Eddie Bane | Luis Tiant | Bill Campbell | 340 | 370 | -30 |
| 1976-07-11 | @ BOS | 83 | L 4-6 | 39-44 | 4 | 26,580 | Bill Singer | Fergie Jenkins | Fergie Jenkins | Bill Singer | Jim Willoughby | 344 | 376 | -32 |
| 1976-07-15 | vs CLE | 84 | W 5-2 | 40-44 | 4 | 7,791 | Eddie Bane | Jackie Brown | Eddie Bane | Jackie Brown | Bill Campbell | 349 | 378 | -29 |
| 1976-07-16 | vs CLE | 85 | L 6-7 | 40-45 | 4 | 8,962 | Bill Singer | Pat Dobson | Pat Dobson | Bill Singer | Dennis Eckersley | 355 | 385 | -30 |
| 1976-07-17 | vs CLE | 86 | L 0-4 | 40-46 | 4 | 22,290 | Pete Redfern | Rick Waits | Rick Waits | Pete Redfern | | 355 | 389 | -34 |
| 1976-07-18 | vs CLE | 87 | L 1-6 | 40-47 | 5 | 13,329 | Jim Hughes | Stan Thomas | Stan Thomas | Jim Hughes | | 356 | 395 | -39 |
| 1976-07-19 | vs DET | 88 | W 6-5 | 41-47 | 4 | 5,005 | Eddie Bane | Dave Roberts | Bill Campbell | Dave Roberts | | 362 | 400 | -38 |
| 1976-07-20 | vs DET | 89 | L 3-8 | 41-48 | 4 | 30,425 | Bill Singer | Mark Fidrych | Mark Fidrych | Bill Singer | | 365 | 408 | -43 |
| 1976-07-21 | vs BOS | 90 | W 5-1 | 42-48 | 5 | 7,698 | Dave Goltz | Rick Wise | Dave Goltz | Rick Wise | | 370 | 409 | -39 |
| 1976-07-22 | vs BOS | 91 | W 5-1 | 43-48 | 4 | 7,972 | Pete Redfern | Luis Tiant | Pete Redfern | Luis Tiant | | 375 | 410 | -35 |
| 1976-07-23 | @ CHA | 92 | W 6-2 | 44-48 | 4 | 10,126 | Jim Hughes | Francisco Barrios | Tom Burgmeier | Francisco Barrios | | 381 | 412 | -31 |
| 1976-07-24 | @ CHA | 93 | W 17-2 | 45-48 | 4 | 14,997 | Eddie Bane | Jesse Jefferson | Eddie Bane | Jesse Jefferson | | 398 | 414 | -16 |
| 1976-07-25 | @ CHA | 94 | W 13-8 | 46-49 | 4 | 0 | Steve Luebber | Terry Forster | Vic Albury | Terry Forster | | 411 | 422 | -11 |
| 1976-07-25 | @ CHA | 95 | L 4-7 | 46-49 | 4 | 12,651 | Bill Singer | Ken Brett | Ken Brett | Bill Singer | | 415 | 429 | -14 |
| 1976-07-26 | vs TEX | 96 | L 0-3 | 46-50 | 4 | 9,184 | Dave Goltz | Bert Blyleven | Bert Blyleven | Dave Goltz | | 415 | 432 | -17 |
| 1976-07-28 | vs TEX | 97 | W 8-5 | 48-50 | 3 | 0 | Jim Hughes | Steve Hargan | Jim Hughes | Steve Hargan | Bill Campbell | 423 | 437 | -14 |
| 1976-07-28 | vs TEX | 98 | W 8-0 | 48-50 | 3 | 5,983 | Steve Luebber | Steve Barr | Steve Luebber | Steve Barr | | 431 | 437 | -6 |
| 1976-07-29 | vs TEX | 99 | W 2-1 | 49-50 | 3 | 14,203 | Eddie Bane | Jim Umbarger | Eddie Bane | Jim Umbarger | Bill Campbell | 433 | 438 | -5 |
| 1976-07-30 | vs OAK | 100 | W 8-7 | 50-50 | 3 | 12,342 | Bill Singer | Dick Bosman | Tom Burgmeier | Rollie Fingers | | 441 | 445 | -4 |
| 1976-07-31 | vs OAK | 101 | W 6-5 | 51-50 | 3 | 13,515 | Dave Goltz | Paul Mitchell | Dave Goltz | Stan Bahnsen | Bill Campbell | 447 | 450 | -3 |
| 1976-08-01 | vs OAK | 102 | W 8-7 | 53-50 | 2 | 0 | Pete Redfern | Vida Blue | Bill Campbell | Paul Lindblad | | 455 | 457 | -2 |
| 1976-08-01 | vs OAK | 103 | W 6-2 | 53-50 | 2 | 22,921 | Jim Hughes | Glenn Abbott | Tom Johnson | Glenn Abbott | | 461 | 459 | 2 |
| 1976-08-02 | vs OAK | 104 | W 3-0 | 54-50 | 2 | 14,833 | Steve Luebber | Mike Torrez | Steve Luebber | Mike Torrez | | 464 | 459 | 5 |
| 1976-08-03 | @ KCA | 105 | L 1-7 | 54-51 | 2 | 16,939 | Eddie Bane | Marty Pattin | Marty Pattin | Eddie Bane | | 465 | 466 | -1 |
| 1976-08-04 | @ KCA | 106 | L 2-4 | 54-52 | 3 | 15,932 | Dave Goltz | Al Fitzmorris | Al Fitzmorris | Dave Goltz | Mark Littell | 467 | 470 | -3 |
| 1976-08-05 | @ KCA | 107 | L 4-6 | 54-53 | 3 | 14,544 | Bill Singer | Dennis Leonard | Dennis Leonard | Bill Singer | Steve Mingori | 471 | 476 | -5 |
| 1976-08-06 | @ TEX | 108 | L 0-6 | 54-54 | 3 | 23,078 | Pete Redfern | Gaylord Perry | Gaylord Perry | Pete Redfern | | 471 | 482 | -11 |
| 1976-08-07 | @ TEX | 109 | W 3-1 | 55-54 | 3 | 11,954 | Steve Luebber | Tommy Boggs | Steve Luebber | Tommy Boggs | Bill Campbell | 474 | 483 | -9 |
| 1976-08-08 | @ TEX | 110 | L 4-5 | 55-55 | 3 | 7,855 | Eddie Bane | Jim Umbarger | Jeff Terpko | Bill Campbell | | 478 | 488 | -10 |
| 1976-08-10 | @ BAL | 111 | L 0-2 | 55-56 | 3 | 11,796 | Dave Goltz | Jim Palmer | Jim Palmer | Dave Goltz | | 478 | 490 | -12 |
| 1976-08-11 | @ BAL | 112 | W 2-0 | 56-56 | 3 | 12,228 | Bill Singer | Wayne Garland | Bill Singer | Wayne Garland | | 480 | 490 | -10 |
| 1976-08-12 | vs NYA | 113 | L 5-12 | 56-57 | 3 | 20,597 | Steve Luebber | Catfish Hunter | Catfish Hunter | Steve Luebber | | 485 | 502 | -17 |
| 1976-08-13 | vs NYA | 114 | L 3-9 | 56-58 | 3 | 20,746 | Eddie Bane | Ed Figueroa | Ed Figueroa | Eddie Bane | | 488 | 511 | -23 |
| 1976-08-14 | vs NYA | 115 | L 4-5 | 56-59 | 4 | 19,005 | Dave Goltz | Ken Holtzman | Ken Holtzman | Dave Goltz | | 492 | 516 | -24 |
| 1976-08-15 | vs NYA | 116 | W 9-8 | 57-59 | 3 | 22,535 | Bill Singer | Dock Ellis | Jim Hughes | Sparky Lyle | Bill Campbell | 501 | 524 | -23 |
| 1976-08-16 | vs BAL | 117 | L 4-8 | 57-60 | 3 | 5,817 | Steve Luebber | Ross Grimsley | Ross Grimsley | Steve Luebber | | 505 | 532 | -27 |
| 1976-08-17 | vs BAL | 118 | L 3-10 | 57-61 | 3 | 7,850 | Tom Johnson | Rudy May | Rudy May | Tom Johnson | | 508 | 542 | -34 |
| 1976-08-18 | vs BAL | 119 | W 5-1 | 58-61 | 3 | 7,482 | Dave Goltz | Jim Palmer | Dave Goltz | Jim Palmer | Bill Campbell | 513 | 543 | -30 |
| 1976-08-19 | vs BAL | 120 | W 5-4 | 59-61 | 3 | 7,415 | Bill Singer | Mike Flanagan | Bill Singer | Dave Pagan | Bill Campbell | 518 | 547 | -29 |
| 1976-08-20 | @ DET | 121 | L 2-3 | 60-62 | 3 | 0 | Eddie Bane | Dave Roberts | Dave Roberts | Eddie Bane | | 520 | 550 | -30 |
| 1976-08-20 | @ DET | 122 | W 8-5 | 60-62 | 3 | 17,385 | Steve Luebber | Dave Lemanczyk | Tom Burgmeier | Bill Laxton | Bill Campbell | 528 | 555 | -27 |
| 1976-08-21 | @ DET | 123 | W 7-3 | 61-62 | 3 | 34,760 | Pete Redfern | Mark Fidrych | Jim Hughes | Mark Fidrych | | 535 | 558 | -23 |
| 1976-08-22 | @ DET | 124 | W 6-4 | 62-62 | 3 | 14,979 | Dave Goltz | Vern Ruhle | Bill Campbell | John Hiller | | 541 | 562 | -21 |
| 1976-08-23 | @ NYA | 125 | L 4-9 | 62-63 | 3 | 17,558 | Bill Singer | Ken Holtzman | Ken Holtzman | Bill Singer | | 545 | 571 | -26 |
| 1976-08-24 | @ NYA | 126 | L 4-5 | 62-64 | 3 | 18,600 | Eddie Bane | Doyle Alexander | Doyle Alexander | Eddie Bane | Grant Jackson | 549 | 576 | -27 |
| 1976-08-25 | @ NYA | 127 | L 4-5 | 62-65 | 3 | 24,351 | Pete Redfern | Ed Figueroa | Grant Jackson | Tom Burgmeier | | 553 | 581 | -28 |
| 1976-08-27 | @ CLE | 128 | L 3-7 | 62-66 | 3 | 7,439 | Dave Goltz | Jackie Brown | Jackie Brown | Dave Goltz | Stan Thomas | 556 | 588 | -32 |
| 1976-08-28 | @ CLE | 129 | L 3-4 | 62-67 | 3 | 6,071 | Bill Singer | Pat Dobson | Tom Buskey | Jim Hughes | | 559 | 592 | -33 |
| 1976-08-29 | @ CLE | 130 | L 4-7 | 62-68 | 3 | 10,415 | Eddie Bane | Dennis Eckersley | Dennis Eckersley | Eddie Bane | Stan Thomas | 563 | 599 | -36 |
| 1976-08-30 | vs MIL | 131 | W 10-3 | 63-68 | 3 | 5,219 | Pete Redfern | Jerry Augustine | Tom Burgmeier | Jerry Augustine | | 573 | 602 | -29 |
| 1976-08-31 | vs MIL | 132 | W 4-0 | 64-69 | 3 | 0 | Dave Goltz | Bill Travers | Dave Goltz | Bill Travers | | 577 | 602 | -25 |
| 1976-08-31 | vs MIL | 133 | L 3-6 | 64-69 | 3 | 6,987 | Jim Hughes | Jim Slaton | Jim Slaton | Bill Campbell | | 580 | 608 | -28 |
| 1976-09-01 | vs MIL | 134 | W 3-2 | 65-69 | 3 | 4,135 | Bill Singer | Jim Colborn | Bill Campbell | Bill Castro | | 583 | 610 | -27 |
| 1976-09-02 | vs MIL | 135 | W 8-4 | 66-69 | 3 | 3,386 | Eddie Bane | Eduardo Rodriguez | Tom Johnson | Bill Castro | | 591 | 614 | -23 |
| 1976-09-03 | vs CHA | 136 | W 11-1 | 67-69 | 3 | 4,622 | Pete Redfern | Rich Gossage | Pete Redfern | Rich Gossage | Tom Burgmeier | 602 | 615 | -13 |
| 1976-09-04 | vs CHA | 137 | L 0-4 | 67-70 | 3 | 5,933 | Jim Hughes | Ken Brett | Ken Brett | Jim Hughes | | 602 | 619 | -17 |
| 1976-09-05 | vs CHA | 138 | W 18-1 | 68-70 | 3 | 6,602 | Eddie Bane | Bart Johnson | Tom Johnson | Bart Johnson | | 620 | 620 | 0 |
| 1976-09-06 | vs CHA | 139 | W 3-2 | 69-70 | 3 | 6,587 | Bill Singer | Ken Kravec | Bill Campbell | Francisco Barrios | | 623 | 622 | 1 |
| 1976-09-07 | @ TEX | 140 | W 1-0 | 70-70 | 3 | 4,640 | Pete Redfern | Gaylord Perry | Pete Redfern | Gaylord Perry | Bill Campbell | 624 | 622 | 2 |
| 1976-09-08 | @ TEX | 141 | W 3-1 | 71-70 | 3 | 3,777 | Steve Luebber | Tommy Boggs | Steve Luebber | Tommy Boggs | | 627 | 623 | 4 |
| 1976-09-09 | @ TEX | 142 | W 6-0 | 72-70 | 3 | 3,603 | Dave Goltz | Jim Umbarger | Dave Goltz | Jim Umbarger | | 633 | 623 | 10 |
| 1976-09-10 | vs KCA | 143 | W 18-3 | 73-70 | 3 | 8,912 | Jim Hughes | Andy Hassler | Jim Hughes | Andy Hassler | | 651 | 626 | 25 |
| 1976-09-11 | vs KCA | 144 | L 6-8 | 73-71 | 3 | 8,955 | Bill Singer | Doug Bird | Mark Littell | Bill Campbell | | 657 | 634 | 23 |
| 1976-09-12 | vs KCA | 145 | L 6-16 | 73-72 | 3 | 8,101 | Pete Redfern | Marty Pattin | Marty Pattin | Pete Redfern | | 663 | 650 | 13 |
| 1976-09-14 | vs OAK | 146 | L 2-4 | 74-73 | 3 | 0 | Steve Luebber | Vida Blue | Vida Blue | Steve Luebber | | 665 | 654 | 11 |
| 1976-09-14 | vs OAK | 147 | W 4-3 | 74-73 | 3 | 2,923 | Dave Goltz | Dick Bosman | Dave Goltz | Paul Lindblad | | 669 | 657 | 12 |
| 1976-09-15 | @ OAK | 148 | L 2-5 | 74-74 | 3 | 3,774 | Jim Hughes | Mike Torrez | Mike Torrez | Jim Hughes | | 671 | 662 | 9 |
| 1976-09-16 | @ OAK | 149 | W 4-0 | 75-74 | 3 | 4,587 | Bill Singer | Stan Bahnsen | Bill Singer | Stan Bahnsen | | 675 | 662 | 13 |
| 1976-09-17 | @ CAL | 150 | W 11-2 | 76-74 | 3 | 6,248 | Pete Redfern | Don Kirkwood | Pete Redfern | Don Kirkwood | Bill Campbell | 686 | 664 | 22 |
| 1976-09-18 | @ CAL | 151 | L 0-6 | 76-75 | 3 | 20,843 | Dave Goltz | Gary Ross | Gary Ross | Dave Goltz | | 686 | 670 | 16 |
| 1976-09-19 | @ CAL | 152 | W 7-5 | 77-75 | 3 | 7,895 | Steve Luebber | Paul Hartzell | Bill Campbell | Sid Monge | | 693 | 675 | 18 |
| 1976-09-21 | @ CHA | 153 | W 13-6 | 78-75 | 3 | 3,026 | Jim Hughes | Ken Kravec | Tom Burgmeier | Ken Kravec | | 706 | 681 | 25 |
| 1976-09-22 | @ CHA | 154 | W 6-3 | 79-75 | 3 | 3,458 | Bill Singer | Bart Johnson | Bill Singer | Bart Johnson | Bill Campbell | 712 | 684 | 28 |
| 1976-09-23 | @ CHA | 155 | W 3-0 | 80-75 | 3 | 3,278 | Pete Redfern | Ken Brett | Pete Redfern | Ken Brett | | 715 | 684 | 31 |
| 1976-09-25 | vs CAL | 156 | W 6-0 | 81-75 | 3 | 4,942 | Dave Goltz | Nolan Ryan | Dave Goltz | Nolan Ryan | | 721 | 684 | 37 |
| 1976-09-26 | vs CAL | 157 | L 1-4 | 81-76 | 3 | 3,649 | Jim Hughes | Frank Tanana | Frank Tanana | Jim Hughes | | 722 | 688 | 34 |
| 1976-09-28 | vs TEX | 158 | L 0-7 | 81-77 | 3 | 2,122 | Bill Singer | Gaylord Perry | Gaylord Perry | Bill Singer | | 722 | 695 | 27 |
| 1976-09-29 | vs TEX | 159 | W 9-1 | 82-77 | 3 | 2,444 | Pete Redfern | Tommy Boggs | Pete Redfern | Tommy Boggs | | 731 | 696 | 35 |
| 1976-10-01 | @ KCA | 160 | W 4-3 | 83-77 | 3 | 38,482 | Dave Goltz | Doug Bird | Bill Campbell | Mark Littell | | 735 | 699 | 36 |
| 1976-10-02 | @ KCA | 161 | W 3-2 | 84-77 | 3 | 14,087 | Bill Singer | Dennis Leonard | Bill Singer | Andy Hassler | Bill Campbell | 738 | 701 | 37 |
| 1976-10-03 | @ KCA | 162 | W 5-3 | 85-77 | 3 | 15,665 | Jim Hughes | Paul Splittorff | Jim Hughes | Paul Splittorff | | 743 | 704 | 39 |