| 1976-04-08 | vs NYA | 1 | W 5-0 | - | | 44,868 | Jim Slaton | Catfish Hunter | Jim Slaton | Catfish Hunter | | 5 | 0 | 5 |
| 1976-04-10 | vs NYA | 2 | L 7-9 | - | | 10,871 | Bill Travers | Ed Figueroa | Sparky Lyle | Tom Murphy | Ken Brett | 12 | 9 | 3 |
| 1976-04-13 | @ DET | 3 | W 1-0 | - | | 48,612 | Jim Slaton | Ray Bare | Jim Slaton | John Hiller | | 13 | 9 | 4 |
| 1976-04-16 | @ TEX | 4 | W 3-1 | - | | 22,205 | Jim Colborn | Jim Umbarger | Jim Colborn | Jim Umbarger | Eduardo Rodriguez | 16 | 10 | 6 |
| 1976-04-18 | @ TEX | 5 | L 4-7 | - | | 0 | Jim Slaton | Bill Singer | Bill Singer | Jim Slaton | Steve Foucault | 20 | 17 | 3 |
| 1976-04-18 | @ TEX | 6 | W 4-1 | - | | 13,944 | Bill Travers | Nelson Briles | Bill Travers | Nelson Briles | Eduardo Rodriguez | 24 | 18 | 6 |
| 1976-04-20 | vs KCA | 7 | W 5-4 | - | | 4,902 | Pete Broberg | Dennis Leonard | Pete Broberg | Dennis Leonard | Eduardo Rodriguez | 29 | 22 | 7 |
| 1976-04-22 | vs KCA | 8 | L 1-2 | - | | 5,196 | Jim Colborn | Al Fitzmorris | Doug Bird | Jim Colborn | | 30 | 24 | 6 |
| 1976-04-23 | vs CAL | 9 | W 4-2 | - | | 3,957 | Jim Slaton | Gary Ross | Jim Slaton | Gary Ross | Eduardo Rodriguez | 34 | 26 | 8 |
| 1976-04-26 | vs CAL | 10 | W 1-0 | - | | 3,841 | Jim Colborn | Frank Tanana | Jim Colborn | Frank Tanana | Eduardo Rodriguez | 35 | 26 | 9 |
| 1976-04-28 | @ CHA | 11 | W 4-1 | - | | 1,144 | Bill Travers | Wilbur Wood | Bill Travers | Wilbur Wood | Eduardo Rodriguez | 39 | 27 | 12 |
| 1976-04-29 | @ CHA | 12 | W 8-5 | - | | 1,709 | Jim Slaton | Rich Gossage | Eduardo Rodriguez | Clay Carroll | | 47 | 32 | 15 |
| 1976-05-01 | @ MIN | 13 | L 5-9 | - | | 6,874 | Pete Broberg | Joe Decker | Bill Campbell | Pete Broberg | | 52 | 41 | 11 |
| 1976-05-04 | vs TEX | 14 | L 4-7 | - | | 6,111 | Jim Colborn | Nelson Briles | Nelson Briles | Jim Colborn | Steve Foucault | 56 | 48 | 8 |
| 1976-05-07 | vs MIN | 15 | W 4-3 | - | | 6,114 | Jim Slaton | Jim Hughes | Jim Slaton | Jim Hughes | Eduardo Rodriguez | 60 | 51 | 9 |
| 1976-05-08 | vs MIN | 16 | L 2-13 | - | | 21,619 | Bill Travers | Joe Decker | Joe Decker | Bill Travers | | 62 | 64 | -2 |
| 1976-05-09 | vs MIN | 17 | L 4-6 | - | | 17,604 | Pete Broberg | Dave Goltz | Bill Campbell | Eduardo Rodriguez | | 66 | 70 | -4 |
| 1976-05-11 | vs BAL | 18 | L 2-5 | - | | 6,236 | Jim Colborn | Mike Cuellar | Mike Cuellar | Jim Colborn | Wayne Garland | 68 | 75 | -7 |
| 1976-05-12 | vs BAL | 19 | L 6-8 | - | | 5,657 | Jim Slaton | Ken Holtzman | Doyle Alexander | Jerry Augustine | | 74 | 83 | -9 |
| 1976-05-13 | vs BAL | 20 | L 3-5 | - | | 7,173 | Bill Travers | Jim Palmer | Jim Palmer | Bill Travers | | 77 | 88 | -11 |
| 1976-05-14 | @ BOS | 21 | L 1-2 | - | | 25,069 | Pete Broberg | Dick Pole | Dick Pole | Pete Broberg | Jim Willoughby | 78 | 90 | -12 |
| 1976-05-15 | @ BOS | 22 | L 4-9 | - | | 26,327 | Jim Colborn | Fergie Jenkins | Fergie Jenkins | Eduardo Rodriguez | | 82 | 99 | -17 |
| 1976-05-16 | @ BOS | 23 | W 11-5 | - | | 28,814 | Jim Slaton | Rick Wise | Jim Slaton | Rick Wise | | 93 | 104 | -11 |
| 1976-05-17 | @ BAL | 24 | L 3-4 | - | | 10,755 | Bill Travers | Jim Palmer | Dyar Miller | Eduardo Rodriguez | | 96 | 108 | -12 |
| 1976-05-19 | @ BAL | 25 | L 3-5 | - | | 4,839 | Jim Colborn | Mike Cuellar | Mike Cuellar | Jim Colborn | Grant Jackson | 99 | 113 | -14 |
| 1976-05-21 | @ CLE | 26 | W 4-3 | - | | 9,168 | Bill Travers | Pat Dobson | Bill Travers | Pat Dobson | | 103 | 116 | -13 |
| 1976-05-22 | @ CLE | 27 | W 6-5 | - | | 8,784 | Jim Slaton | Dennis Eckersley | Jim Slaton | Jim Bibby | Tom Murphy | 109 | 121 | -12 |
| 1976-05-23 | @ CLE | 28 | L 1-2 | - | | 0 | Pete Broberg | Jackie Brown | Jackie Brown | Pete Broberg | Jim Kern | 110 | 123 | -13 |
| 1976-05-23 | @ CLE | 29 | L 5-8 | - | | 27,751 | Bill Champion | Fritz Peterson | Jim Kern | Ed Sprague | | 115 | 131 | -16 |
| 1976-05-24 | @ NYA | 30 | L 2-5 | - | | 11,316 | Jim Colborn | Ed Figueroa | Ed Figueroa | Jim Colborn | | 117 | 136 | -19 |
| 1976-05-25 | @ NYA | 31 | W 1-0 | - | | 10,477 | Bill Travers | Dock Ellis | Bill Travers | Dock Ellis | | 118 | 136 | -18 |
| 1976-05-26 | vs BOS | 32 | W 6-2 | - | | 11,496 | Jim Slaton | Dick Pole | Jim Slaton | Dick Pole | | 124 | 138 | -14 |
| 1976-05-27 | vs BOS | 33 | L 1-2 | - | | 14,308 | Pete Broberg | Fergie Jenkins | Fergie Jenkins | Pete Broberg | | 125 | 140 | -15 |
| 1976-05-29 | vs CLE | 34 | L 0-6 | - | | 8,460 | Jim Colborn | Jackie Brown | Jackie Brown | Jim Colborn | | 125 | 146 | -21 |
| 1976-05-30 | vs CLE | 35 | W 5-4 | - | | 36,119 | Bill Travers | Dennis Eckersley | Bill Travers | Dennis Eckersley | Eduardo Rodriguez | 130 | 150 | -20 |
| 1976-05-31 | @ DET | 36 | L 4-5 | - | | 17,894 | Jim Slaton | Mark Fidrych | Mark Fidrych | Ed Sprague | | 134 | 155 | -21 |
| 1976-06-01 | @ DET | 37 | L 7-8 | - | | 0 | Pete Broberg | Ray Bare | John Hiller | Eduardo Rodriguez | | 141 | 163 | -22 |
| 1976-06-01 | @ DET | 38 | L 5-6 | - | | 12,503 | Bill Champion | Joe Coleman | John Hiller | Eduardo Rodriguez | | 146 | 169 | -23 |
| 1976-06-02 | @ DET | 39 | L 4-6 | - | | 9,283 | Jim Colborn | Vern Ruhle | Vern Ruhle | Jim Colborn | Jim Crawford | 150 | 175 | -25 |
| 1976-06-03 | @ DET | 40 | W 6-2 | - | | 10,866 | Bill Travers | Dave Roberts | Bill Travers | Dave Roberts | | 156 | 177 | -21 |
| 1976-06-04 | @ KCA | 41 | L 3-4 | - | | 16,899 | Jim Slaton | Dennis Leonard | Dennis Leonard | Jim Slaton | | 159 | 181 | -22 |
| 1976-06-05 | @ KCA | 42 | L 4-5 | - | | 0 | Pete Broberg | Al Fitzmorris | Al Fitzmorris | Pete Broberg | Mark Littell | 163 | 186 | -23 |
| 1976-06-05 | @ KCA | 43 | L 2-7 | - | | 35,817 | Bill Champion | Paul Splittorff | Paul Splittorff | Bill Champion | | 165 | 193 | -28 |
| 1976-06-06 | @ KCA | 44 | W 4-3 | - | | 15,508 | Jim Colborn | Doug Bird | Jerry Augustine | Marty Pattin | | 169 | 196 | -27 |
| 1976-06-08 | vs CHA | 45 | W 2-0 | - | | 17,973 | Bill Travers | Bart Johnson | Bill Travers | Bart Johnson | | 171 | 196 | -25 |
| 1976-06-09 | vs CHA | 46 | L 2-4 | - | | 16,290 | Jim Slaton | Rich Gossage | Rich Gossage | Jim Slaton | Clay Carroll | 173 | 200 | -27 |
| 1976-06-10 | vs CHA | 47 | L 5-12 | - | | 12,769 | Jerry Augustine | Francisco Barrios | Francisco Barrios | Jerry Augustine | | 178 | 212 | -34 |
| 1976-06-11 | vs OAK | 48 | W 4-2 | - | | 19,059 | Jim Colborn | Vida Blue | Jim Colborn | Vida Blue | | 182 | 214 | -32 |
| 1976-06-12 | vs OAK | 49 | L 1-2 | - | | 29,025 | Bill Travers | Paul Mitchell | Paul Mitchell | Bill Travers | Rollie Fingers | 183 | 216 | -33 |
| 1976-06-13 | vs OAK | 50 | W 5-4 | - | | 31,457 | Jim Slaton | Mike Torrez | Jim Slaton | Mike Torrez | Bill Castro | 188 | 220 | -32 |
| 1976-06-14 | vs CAL | 51 | W 8-2 | - | | 6,252 | Jerry Augustine | Frank Tanana | Jerry Augustine | Frank Tanana | Danny Frisella | 196 | 222 | -26 |
| 1976-06-15 | @ CAL | 52 | L 0-1 | - | | 11,332 | Jim Colborn | Nolan Ryan | Nolan Ryan | Jim Colborn | | 196 | 223 | -27 |
| 1976-06-16 | @ CAL | 53 | W 9-0 | - | | 8,653 | Bill Travers | Sid Monge | Bill Travers | Sid Monge | | 205 | 223 | -18 |
| 1976-06-17 | @ CAL | 54 | L 0-2 | - | | 7,701 | Jim Slaton | Gary Ross | Gary Ross | Jim Slaton | | 205 | 225 | -20 |
| 1976-06-18 | @ OAK | 55 | W 3-2 | - | | 4,108 | Jerry Augustine | Dick Bosman | Bill Castro | Jim Todd | | 208 | 227 | -19 |
| 1976-06-19 | @ OAK | 56 | L 4-7 | - | | 23,408 | Jim Colborn | Glenn Abbott | Glenn Abbott | Jim Colborn | Paul Lindblad | 212 | 234 | -22 |
| 1976-06-20 | @ OAK | 57 | L 5-7 | - | | 7,462 | Bill Travers | Mike Torrez | Stan Bahnsen | Bill Travers | Jim Todd | 217 | 241 | -24 |
| 1976-06-21 | vs DET | 58 | L 2-3 | - | | 10,642 | Jim Slaton | Vern Ruhle | John Hiller | Jim Slaton | | 219 | 244 | -25 |
| 1976-06-22 | vs DET | 59 | L 4-10 | - | | 13,061 | Jerry Augustine | Dave Roberts | Dave Roberts | Jerry Augustine | Steve Grilli | 223 | 254 | -31 |
| 1976-06-23 | vs DET | 60 | W 9-5 | - | | 9,807 | Jim Colborn | Frank MacCormack | Jim Colborn | Frank MacCormack | | 232 | 259 | -27 |
| 1976-06-25 | @ NYA | 61 | L 0-1 | - | | 21,389 | Bill Travers | Dock Ellis | Dock Ellis | Bill Travers | | 232 | 260 | -28 |
| 1976-06-26 | @ NYA | 62 | L 3-6 | - | | 29,395 | Jim Slaton | Ed Figueroa | Ed Figueroa | Jim Slaton | Sparky Lyle | 235 | 266 | -31 |
| 1976-06-27 | @ NYA | 63 | L 2-6 | - | | 0 | Jerry Augustine | Catfish Hunter | Catfish Hunter | Jerry Augustine | Sparky Lyle | 237 | 272 | -35 |
| 1976-06-27 | @ NYA | 64 | L 2-10 | - | | 41,249 | Pete Broberg | Dick Tidrow | Dick Tidrow | Pete Broberg | | 239 | 282 | -43 |
| 1976-06-28 | @ CLE | 65 | L 3-5 | - | | 8,289 | Jim Colborn | Don Hood | Jim Bibby | Jim Colborn | Dave LaRoche | 242 | 287 | -45 |
| 1976-06-29 | @ CLE | 66 | L 1-4 | - | | 18,932 | Bill Travers | Jackie Brown | Jackie Brown | Bill Travers | Jim Kern | 243 | 291 | -48 |
| 1976-07-01 | vs BOS | 67 | W 6-5 | - | | 16,182 | Jim Slaton | Fergie Jenkins | Danny Frisella | Reggie Cleveland | | 249 | 296 | -47 |
| 1976-07-02 | vs BOS | 68 | L 0-3 | - | | 13,744 | Jerry Augustine | Dick Pole | Dick Pole | Jerry Augustine | Jim Willoughby | 249 | 299 | -50 |
| 1976-07-03 | vs BOS | 69 | W 6-2 | - | | 21,331 | Jim Colborn | Rick Jones | Jim Colborn | Reggie Cleveland | | 255 | 301 | -46 |
| 1976-07-04 | vs BOS | 70 | L 1-3 | - | | 13,552 | Pete Broberg | Rick Wise | Rick Wise | Pete Broberg | | 256 | 304 | -48 |
| 1976-07-05 | vs MIN | 71 | W 3-2 | - | | 8,074 | Bill Travers | Eddie Bane | Bill Travers | Eddie Bane | | 259 | 306 | -47 |
| 1976-07-06 | vs MIN | 72 | W 6-2 | - | | 7,383 | Jim Slaton | Jim Hughes | Jim Slaton | Jim Hughes | Danny Frisella | 265 | 308 | -43 |
| 1976-07-07 | vs MIN | 73 | L 2-8 | - | | 8,160 | Jerry Augustine | Bill Singer | Bill Singer | Jerry Augustine | | 267 | 316 | -49 |
| 1976-07-08 | vs TEX | 74 | W 5-4 | - | | 5,181 | Jim Colborn | Nelson Briles | Danny Frisella | Joe Hoerner | | 272 | 320 | -48 |
| 1976-07-09 | vs TEX | 75 | W 7-2 | - | | 22,912 | Pete Broberg | Jim Umbarger | Eduardo Rodriguez | Jim Umbarger | | 279 | 322 | -43 |
| 1976-07-10 | vs TEX | 76 | W 3-1 | - | | 25,170 | Bill Travers | Gaylord Perry | Bill Travers | Gaylord Perry | Danny Frisella | 282 | 323 | -41 |
| 1976-07-11 | vs TEX | 77 | W 6-3 | - | | 0 | Jim Slaton | Bert Blyleven | Jim Slaton | Bert Blyleven | | 288 | 326 | -38 |
| 1976-07-11 | vs TEX | 78 | W 5-4 | - | | 28,149 | Jerry Augustine | Steve Barr | Bill Castro | Steve Foucault | | 293 | 330 | -37 |
| 1976-07-15 | @ CHA | 79 | L 3-5 | - | | 13,892 | Jim Slaton | Ken Brett | Ken Brett | Jim Slaton | | 296 | 335 | -39 |
| 1976-07-16 | @ CHA | 80 | L 2-5 | - | | 16,791 | Jerry Augustine | Bart Johnson | Bart Johnson | Jerry Augustine | Dave Hamilton | 298 | 340 | -42 |
| 1976-07-17 | @ CHA | 81 | W 9-2 | - | | 15,261 | Jim Colborn | Rich Gossage | Jim Colborn | Rich Gossage | | 307 | 342 | -35 |
| 1976-07-18 | @ CHA | 82 | L 3-13 | - | | 20,302 | Bill Travers | Francisco Barrios | Francisco Barrios | Bill Travers | | 310 | 355 | -45 |
| 1976-07-19 | vs CAL | 83 | L 2-4 | - | | 0 | Eduardo Rodriguez | Paul Hartzell | Paul Hartzell | Eduardo Rodriguez | John Verhoeven | 312 | 359 | -47 |
| 1976-07-19 | vs CAL | 84 | L 1-6 | - | | 11,196 | Jim Slaton | Don Kirkwood | Don Kirkwood | Jim Slaton | | 313 | 365 | -52 |
| 1976-07-20 | vs CAL | 85 | W 6-2 | - | | 10,134 | Jerry Augustine | Gary Ross | Jerry Augustine | Gary Ross | Danny Frisella | 319 | 367 | -48 |
| 1976-07-21 | @ KCA | 86 | W 5-0 | - | | 15,445 | Bill Travers | Al Fitzmorris | Bill Travers | Al Fitzmorris | Danny Frisella | 324 | 367 | -43 |
| 1976-07-22 | @ KCA | 87 | L 1-3 | - | | 16,133 | Jim Colborn | Paul Splittorff | Paul Splittorff | Jim Colborn | Mark Littell | 325 | 370 | -45 |
| 1976-07-23 | @ BAL | 88 | W 4-3 | - | | 12,451 | Jim Slaton | Jim Palmer | Jim Slaton | Tippy Martinez | Danny Frisella | 329 | 373 | -44 |
| 1976-07-24 | @ BAL | 89 | W 4-1 | - | | 0 | Eduardo Rodriguez | Mike Cuellar | Eduardo Rodriguez | Mike Cuellar | Bill Castro | 333 | 374 | -41 |
| 1976-07-24 | @ BAL | 90 | W 5-0 | - | | 17,934 | Jerry Augustine | Wayne Garland | Jerry Augustine | Wayne Garland | | 338 | 374 | -36 |
| 1976-07-25 | @ BAL | 91 | W 3-1 | - | | 9,414 | Bill Travers | Dave Pagan | Bill Travers | Dave Pagan | | 341 | 375 | -34 |
| 1976-07-26 | vs DET | 92 | L 3-4 | - | | 9,729 | Jim Colborn | Frank MacCormack | John Hiller | Danny Frisella | | 344 | 379 | -35 |
| 1976-07-27 | vs DET | 93 | W 6-4 | - | | 14,020 | Jim Slaton | Ray Bare | Jim Slaton | Ray Bare | Bill Castro | 350 | 383 | -33 |
| 1976-07-28 | vs DET | 94 | L 0-1 | - | | 13,865 | Jerry Augustine | Dave Roberts | Dave Roberts | Jerry Augustine | | 350 | 384 | -34 |
| 1976-07-30 | vs CLE | 95 | L 2-7 | - | | 27,165 | Eduardo Rodriguez | Dennis Eckersley | Dennis Eckersley | Eduardo Rodriguez | | 352 | 391 | -39 |
| 1976-07-31 | vs CLE | 96 | L 0-2 | - | | 0 | Bill Travers | Jim Bibby | Jim Bibby | Bill Travers | Jim Kern | 352 | 393 | -41 |
| 1976-07-31 | vs CLE | 97 | W 6-5 | - | | 18,175 | Jim Slaton | Rick Waits | Bill Castro | Jim Kern | | 358 | 398 | -40 |
| 1976-08-01 | vs CLE | 98 | L 3-4 | - | | 14,458 | Jerry Augustine | Jackie Brown | Don Hood | Bill Castro | Jim Kern | 361 | 402 | -41 |
| 1976-08-02 | vs BAL | 99 | W 7-1 | - | | 8,901 | Jim Colborn | Rudy May | Jim Colborn | Rudy May | | 368 | 403 | -35 |
| 1976-08-03 | vs BAL | 100 | W 4-2 | - | | 9,282 | Eduardo Rodriguez | Ross Grimsley | Eduardo Rodriguez | Ross Grimsley | | 372 | 405 | -33 |
| 1976-08-04 | vs NYA | 101 | W 4-3 | - | | 0 | Bill Travers | Catfish Hunter | Bill Travers | Catfish Hunter | | 376 | 408 | -32 |
| 1976-08-04 | vs NYA | 102 | L 2-7 | - | | 22,543 | Jim Slaton | Ken Holtzman | Ken Holtzman | Jim Slaton | | 378 | 415 | -37 |
| 1976-08-05 | vs NYA | 103 | W 9-3 | - | | 27,156 | Jerry Augustine | Dock Ellis | Danny Frisella | Dock Ellis | | 387 | 418 | -31 |
| 1976-08-06 | @ BOS | 104 | L 1-2 | - | | 25,544 | Jim Colborn | Rick Wise | Tom Murphy | Jim Colborn | | 388 | 420 | -32 |
| 1976-08-07 | @ BOS | 105 | L 0-3 | - | | 24,514 | Eduardo Rodriguez | Luis Tiant | Luis Tiant | Eduardo Rodriguez | Jim Willoughby | 388 | 423 | -35 |
| 1976-08-10 | @ OAK | 106 | L 1-2 | - | | 4,463 | Jim Slaton | Vida Blue | Vida Blue | Jim Slaton | | 389 | 425 | -36 |
| 1976-08-11 | @ OAK | 107 | L 5-8 | - | | 3,395 | Bill Travers | Mike Torrez | Mike Torrez | Bill Travers | | 394 | 433 | -39 |
| 1976-08-12 | @ OAK | 108 | L 3-4 | - | | 3,730 | Eduardo Rodriguez | Paul Mitchell | Rollie Fingers | Bill Castro | | 397 | 437 | -40 |
| 1976-08-13 | @ CAL | 109 | W 2-0 | - | | 8,244 | Jerry Augustine | Paul Hartzell | Jerry Augustine | Paul Hartzell | | 399 | 437 | -38 |
| 1976-08-14 | @ CAL | 110 | W 4-3 | - | | 15,452 | Jim Slaton | Don Kirkwood | Ray Sadecki | Mike Overy | Danny Frisella | 403 | 440 | -37 |
| 1976-08-15 | @ CAL | 111 | W 5-3 | - | | 7,405 | Bill Travers | Gary Ross | Bill Travers | Gary Ross | Bill Castro | 408 | 443 | -35 |
| 1976-08-16 | vs OAK | 112 | W 4-3 | - | | 9,019 | Jim Colborn | Dick Bosman | Danny Frisella | Rollie Fingers | | 412 | 446 | -34 |
| 1976-08-17 | vs OAK | 113 | L 4-5 | - | | 14,736 | Eduardo Rodriguez | Mike Norris | Paul Lindblad | Eduardo Rodriguez | Rollie Fingers | 416 | 451 | -35 |
| 1976-08-18 | vs OAK | 114 | W 3-1 | - | | 13,013 | Jim Slaton | Vida Blue | Jim Slaton | Vida Blue | Ray Sadecki | 419 | 452 | -33 |
| 1976-08-19 | vs KCA | 115 | W 6-4 | - | | 10,553 | Jerry Augustine | Dennis Leonard | Jerry Augustine | Dennis Leonard | Danny Frisella | 425 | 456 | -31 |
| 1976-08-20 | vs KCA | 116 | L 0-3 | - | | 15,043 | Bill Travers | Andy Hassler | Andy Hassler | Bill Travers | | 425 | 459 | -34 |
| 1976-08-21 | vs KCA | 117 | L 2-6 | - | | 17,725 | Jim Colborn | Marty Pattin | Marty Pattin | Jim Colborn | Mark Littell | 427 | 465 | -38 |
| 1976-08-22 | vs KCA | 118 | L 4-7 | - | | 16,596 | Jim Slaton | Doug Bird | Doug Bird | Danny Frisella | Mark Littell | 431 | 472 | -41 |
| 1976-08-23 | @ TEX | 119 | W 6-2 | - | | 5,283 | Eduardo Rodriguez | Jim Umbarger | Eduardo Rodriguez | Jim Umbarger | Bill Castro | 437 | 474 | -37 |
| 1976-08-24 | @ TEX | 120 | W 1-0 | - | | 6,370 | Jerry Augustine | Nelson Briles | Jerry Augustine | Steve Foucault | | 438 | 474 | -36 |
| 1976-08-25 | @ TEX | 121 | W 5-1 | - | | 6,121 | Bill Travers | Bert Blyleven | Bill Travers | Bert Blyleven | Bill Castro | 443 | 475 | -32 |
| 1976-08-27 | vs CHA | 122 | L 2-5 | - | | 14,950 | Jim Slaton | Ken Kravec | Ken Kravec | Jim Slaton | Dave Hamilton | 445 | 480 | -35 |
| 1976-08-28 | vs CHA | 123 | W 10-8 | - | | 15,934 | Jim Colborn | Rich Gossage | Jim Colborn | Rich Gossage | | 455 | 488 | -33 |
| 1976-08-29 | vs CHA | 124 | L 0-2 | - | | 22,225 | Eduardo Rodriguez | Ken Brett | Ken Brett | Eduardo Rodriguez | Dave Hamilton | 455 | 490 | -35 |
| 1976-08-30 | @ MIN | 125 | L 3-10 | - | | 5,219 | Jerry Augustine | Pete Redfern | Tom Burgmeier | Jerry Augustine | | 458 | 500 | -42 |
| 1976-08-31 | @ MIN | 126 | L 0-4 | - | | 0 | Bill Travers | Dave Goltz | Dave Goltz | Bill Travers | | 458 | 504 | -46 |
| 1976-08-31 | @ MIN | 127 | W 6-3 | - | | 6,987 | Jim Slaton | Jim Hughes | Jim Slaton | Bill Campbell | | 464 | 507 | -43 |
| 1976-09-01 | @ MIN | 128 | L 2-3 | - | | 4,135 | Jim Colborn | Bill Singer | Bill Campbell | Bill Castro | | 466 | 510 | -44 |
| 1976-09-02 | @ MIN | 129 | L 4-8 | - | | 3,386 | Eduardo Rodriguez | Eddie Bane | Tom Johnson | Bill Castro | | 470 | 518 | -48 |
| 1976-09-03 | @ DET | 130 | W 11-2 | - | | 32,951 | Jerry Augustine | Mark Fidrych | Jerry Augustine | Mark Fidrych | | 481 | 520 | -39 |
| 1976-09-04 | @ DET | 131 | L 0-4 | - | | 10,303 | Bill Travers | Vern Ruhle | Vern Ruhle | Bill Travers | | 481 | 524 | -43 |
| 1976-09-05 | @ DET | 132 | W 8-6 | - | | 9,896 | Jim Slaton | Ray Bare | Ray Sadecki | Ray Bare | Danny Frisella | 489 | 530 | -41 |
| 1976-09-06 | vs CLE | 133 | W 3-2 | - | | 0 | Jim Colborn | Stan Thomas | Bill Castro | Stan Thomas | | 492 | 532 | -40 |
| 1976-09-06 | vs CLE | 134 | L 2-3 | - | | 10,627 | Eduardo Rodriguez | Jim Bibby | Jim Bibby | Eduardo Rodriguez | Jim Kern | 494 | 535 | -41 |
| 1976-09-07 | vs CLE | 135 | W 17-4 | - | | 4,980 | Gary Beare | Jackie Brown | Gary Beare | Jackie Brown | | 511 | 539 | -28 |
| 1976-09-08 | @ NYA | 136 | L 0-8 | - | | 12,965 | Jerry Augustine | Ed Figueroa | Ed Figueroa | Jerry Augustine | | 511 | 547 | -36 |
| 1976-09-09 | @ NYA | 137 | L 2-4 | - | | 11,186 | Bill Travers | Ken Holtzman | Ken Holtzman | Bill Travers | | 513 | 551 | -38 |
| 1976-09-10 | @ NYA | 138 | L 4-6 | - | | 16,607 | Jim Slaton | Catfish Hunter | Catfish Hunter | Jim Slaton | | 517 | 557 | -40 |
| 1976-09-11 | vs BAL | 139 | L 1-5 | - | | 0 | Eduardo Rodriguez | Wayne Garland | Wayne Garland | Eduardo Rodriguez | | 518 | 562 | -44 |
| 1976-09-11 | vs BAL | 140 | L 2-3 | - | | 9,079 | Jim Colborn | Mike Flanagan | Mike Flanagan | Jim Colborn | | 520 | 565 | -45 |
| 1976-09-12 | vs BAL | 141 | L 1-3 | - | | 5,193 | Jerry Augustine | Jim Palmer | Jim Palmer | Jerry Augustine | | 521 | 568 | -47 |
| 1976-09-13 | vs BAL | 142 | L 3-5 | - | | 3,923 | Bill Travers | Rudy May | Fred Holdsworth | Bill Castro | | 524 | 573 | -49 |
| 1976-09-14 | vs BOS | 143 | W 3-2 | - | | 4,298 | Jim Slaton | Rick Wise | Danny Frisella | Jim Willoughby | | 527 | 575 | -48 |
| 1976-09-15 | vs BOS | 144 | L 1-2 | - | | 3,656 | Gary Beare | Reggie Cleveland | Reggie Cleveland | Gary Beare | Tom Murphy | 528 | 577 | -49 |
| 1976-09-16 | vs BOS | 145 | L 3-4 | - | | 3,545 | Jim Colborn | Rick Kreuger | Rick Kreuger | Bill Castro | Tom Murphy | 531 | 581 | -50 |
| 1976-09-17 | vs NYA | 146 | L 3-5 | - | | 40,383 | Jerry Augustine | Ed Figueroa | Ed Figueroa | Kevin Kobel | Dick Tidrow | 534 | 586 | -52 |
| 1976-09-18 | vs NYA | 147 | L 3-5 | - | | 6,283 | Bill Travers | Dock Ellis | Dock Ellis | Bill Travers | Sparky Lyle | 537 | 591 | -54 |
| 1976-09-19 | vs NYA | 148 | L 1-2 | - | | 6,887 | Jim Slaton | Catfish Hunter | Catfish Hunter | Jim Slaton | | 538 | 593 | -55 |
| 1976-09-20 | vs NYA | 149 | W 4-2 | - | | 3,455 | Gary Beare | Ken Holtzman | Gary Beare | Ken Holtzman | Bill Castro | 542 | 595 | -53 |
| 1976-09-21 | @ BOS | 150 | L 1-7 | - | | 0 | Moose Haas | Luis Tiant | Luis Tiant | Moose Haas | | 543 | 602 | -59 |
| 1976-09-21 | @ BOS | 151 | W 3-1 | - | | 17,840 | Jim Colborn | Rick Kreuger | Jim Colborn | Rick Kreuger | | 546 | 603 | -57 |
| 1976-09-22 | @ BOS | 152 | L 3-6 | - | | 11,796 | Jerry Augustine | Dick Pole | Dick Pole | Jerry Augustine | Jim Willoughby | 549 | 609 | -60 |
| 1976-09-23 | @ BOS | 153 | L 3-10 | - | | 6,154 | Bill Travers | Bill Lee | Bill Lee | Bill Travers | | 552 | 619 | -67 |
| 1976-09-24 | @ CLE | 154 | L 0-2 | - | | 3,707 | Jim Slaton | Dennis Eckersley | Dennis Eckersley | Jim Slaton | | 552 | 621 | -69 |
| 1976-09-25 | @ CLE | 155 | L 1-3 | - | | 4,614 | Gary Beare | Pat Dobson | Pat Dobson | Gary Beare | Jim Kern | 553 | 624 | -71 |
| 1976-09-28 | @ BAL | 156 | L 5-7 | - | | 0 | Moose Haas | Wayne Garland | Wayne Garland | Eduardo Rodriguez | | 558 | 631 | -73 |
| 1976-09-28 | @ BAL | 157 | L 3-7 | - | | 4,598 | Jim Colborn | Rudy May | Rudy May | Jim Colborn | | 561 | 638 | -77 |
| 1976-09-29 | @ BAL | 158 | W 6-3 | - | | 8,119 | Jerry Augustine | Scott McGregor | Jerry Augustine | Scott McGregor | Bill Castro | 567 | 641 | -74 |
| 1976-10-01 | vs DET | 159 | L 0-5 | - | | 6,065 | Bill Travers | John Hiller | John Hiller | Bill Travers | | 567 | 646 | -79 |
| 1976-10-02 | vs DET | 160 | L 1-4 | - | | 9,044 | Jim Slaton | Mark Fidrych | Mark Fidrych | Jim Slaton | | 568 | 650 | -82 |
| 1976-10-03 | vs DET | 161 | L 2-5 | - | | 6,858 | Gary Beare | Dave Roberts | Dave Roberts | Gary Beare | | 570 | 655 | -85 |