| 1976-04-10 | @ CLE | 1 | W 3-1 | 1-0 | 2 | 58,478 | Joe Coleman | Dennis Eckersley | Joe Coleman | Dennis Eckersley | John Hiller | 3 | 1 | 2 |
| 1976-04-13 | vs MIL | 2 | L 0-1 | 1-1 | 4 | 48,612 | Ray Bare | Jim Slaton | Jim Slaton | John Hiller | | 3 | 2 | 1 |
| 1976-04-16 | @ CAL | 3 | L 5-6 | 1-2 | 5 | 9,873 | Joe Coleman | Don Kirkwood | Jim Brewer | Steve Grilli | | 8 | 8 | 0 |
| 1976-04-17 | @ CAL | 4 | W 2-0 | 2-2 | 4 | 18,464 | Dave Roberts | Gary Ross | Dave Roberts | Gary Ross | | 10 | 8 | 2 |
| 1976-04-18 | @ CAL | 5 | W 6-2 | 3-2 | 3 | 8,938 | Ray Bare | Andy Hassler | Ray Bare | Andy Hassler | John Hiller | 16 | 10 | 6 |
| 1976-04-19 | @ OAK | 6 | L 5-6 | 3-3 | 3 | 18,753 | Vern Ruhle | Stan Bahnsen | Jim Todd | John Hiller | | 21 | 16 | 5 |
| 1976-04-20 | @ OAK | 7 | L 5-6 | 3-4 | 5 | 3,080 | Joe Coleman | Paul Mitchell | Paul Lindblad | Jim Crawford | | 26 | 22 | 4 |
| 1976-04-21 | @ OAK | 8 | W 7-3 | 4-4 | 4 | 2,408 | Dave Roberts | Mike Torrez | Dave Roberts | Mike Torrez | | 33 | 25 | 8 |
| 1976-04-23 | vs TEX | 9 | W 7-6 | 5-4 | 3 | 10,754 | Ray Bare | Jim Umbarger | John Hiller | Steve Barr | | 40 | 31 | 9 |
| 1976-04-24 | vs TEX | 10 | L 4-5 | 5-5 | 4 | 8,862 | Vern Ruhle | Bill Singer | Steve Foucault | John Hiller | | 44 | 36 | 8 |
| 1976-04-27 | vs OAK | 11 | W 10-2 | 6-5 | 4 | 4,612 | Joe Coleman | Vida Blue | Joe Coleman | Vida Blue | Bill Laxton | 54 | 38 | 16 |
| 1976-04-28 | vs OAK | 12 | W 8-1 | 7-5 | 3 | 7,088 | Dave Roberts | Mike Norris | Dave Roberts | Mike Norris | | 62 | 39 | 23 |
| 1976-04-30 | @ CHA | 13 | L 4-8 | 7-6 | 4 | 9,009 | Ray Bare | Terry Forster | Terry Forster | Ray Bare | | 66 | 47 | 19 |
| 1976-05-01 | @ CHA | 14 | W 10-1 | 8-6 | 3 | 17,402 | Vern Ruhle | Bart Johnson | Vern Ruhle | Bart Johnson | | 76 | 48 | 28 |
| 1976-05-04 | vs MIN | 15 | L 4-5 | 8-7 | 3 | 8,818 | Joe Coleman | Dave Goltz | Vic Albury | Bill Laxton | Steve Luebber | 80 | 53 | 27 |
| 1976-05-05 | vs MIN | 16 | L 2-8 | 8-8 | 4 | 8,317 | Dave Roberts | Bert Blyleven | Bert Blyleven | Dave Roberts | | 82 | 61 | 21 |
| 1976-05-07 | vs CHA | 17 | W 5-0 | 9-8 | 3 | 10,059 | Ray Bare | Terry Forster | Ray Bare | Terry Forster | | 87 | 61 | 26 |
| 1976-05-08 | vs CHA | 18 | W 7-1 | 10-8 | 3 | 11,802 | Vern Ruhle | Bart Johnson | Vern Ruhle | Bart Johnson | Bill Laxton | 94 | 62 | 32 |
| 1976-05-09 | vs CHA | 19 | L 2-4 | 10-9 | 3 | 12,250 | Joe Coleman | Wilbur Wood | Wilbur Wood | Joe Coleman | Clay Carroll | 96 | 66 | 30 |
| 1976-05-11 | @ NYA | 20 | W 4-3 | 11-9 | 3 | 12,123 | Dave Roberts | Ed Figueroa | Steve Grilli | Ed Figueroa | | 100 | 69 | 31 |
| 1976-05-12 | @ NYA | 21 | L 6-7 | 11-10 | 3 | 14,575 | Ray Bare | Dock Ellis | Dock Ellis | Ray Bare | Sparky Lyle | 106 | 76 | 30 |
| 1976-05-13 | @ NYA | 22 | W 3-2 | 12-10 | 2 | 14,920 | Vern Ruhle | Rudy May | Vern Ruhle | Rudy May | John Hiller | 109 | 78 | 31 |
| 1976-05-14 | vs CLE | 23 | L 3-6 | 12-11 | 2 | 14,092 | Joe Coleman | Fritz Peterson | Tom Buskey | Joe Coleman | | 112 | 84 | 28 |
| 1976-05-15 | vs CLE | 24 | W 2-1 | 13-11 | 2 | 14,583 | Mark Fidrych | Pat Dobson | Mark Fidrych | Pat Dobson | | 114 | 85 | 29 |
| 1976-05-16 | vs CLE | 25 | L 0-4 | 13-12 | 2 | 51,650 | Ray Bare | Jackie Brown | Jackie Brown | Ray Bare | | 114 | 89 | 25 |
| 1976-05-17 | vs BOS | 26 | L 0-7 | 13-13 | 3 | 11,757 | Joe Coleman | Luis Tiant | Luis Tiant | Joe Coleman | | 114 | 96 | 18 |
| 1976-05-18 | vs BOS | 27 | L 3-5 | 13-14 | 3 | 10,642 | Vern Ruhle | Dick Pole | Jim Willoughby | Jim Crawford | Tom House | 117 | 101 | 16 |
| 1976-05-19 | vs BOS | 28 | L 2-9 | 13-15 | 3 | 13,252 | Dave Roberts | Fergie Jenkins | Fergie Jenkins | Dave Roberts | | 119 | 110 | 9 |
| 1976-05-21 | @ BAL | 29 | L 5-8 | 13-16 | 5 | 12,184 | Ray Bare | Jim Palmer | Doyle Alexander | Ray Bare | | 124 | 118 | 6 |
| 1976-05-22 | @ BAL | 30 | L 4-8 | 13-17 | 5 | 16,337 | Joe Coleman | Ross Grimsley | Wayne Garland | Jim Crawford | | 128 | 126 | 2 |
| 1976-05-23 | @ BAL | 31 | W 10-6 | 14-17 | 4 | 13,628 | Vern Ruhle | Ken Holtzman | John Hiller | Dyar Miller | | 138 | 132 | 6 |
| 1976-05-24 | @ BOS | 32 | L 0-3 | 14-18 | 5 | 20,590 | Dave Roberts | Rick Wise | Rick Wise | Dave Roberts | | 138 | 135 | 3 |
| 1976-05-25 | @ BOS | 33 | L 0-2 | 14-19 | 6 | 21,033 | Mark Fidrych | Luis Tiant | Luis Tiant | Mark Fidrych | | 138 | 137 | 1 |
| 1976-05-26 | vs BAL | 34 | L 0-6 | 15-20 | 6 | 0 | Bill Laxton | Doyle Alexander | Doyle Alexander | Bill Laxton | | 138 | 143 | -5 |
| 1976-05-26 | vs BAL | 35 | W 6-2 | 15-20 | 6 | 24,856 | Ray Bare | Ross Grimsley | Ray Bare | Ross Grimsley | John Hiller | 144 | 145 | -1 |
| 1976-05-27 | vs BAL | 36 | L 3-4 | 15-21 | 6 | 9,397 | Joe Coleman | Ken Holtzman | Ken Holtzman | Joe Coleman | Dyar Miller | 147 | 149 | -2 |
| 1976-05-28 | vs NYA | 37 | L 5-9 | 15-22 | 6 | 19,909 | Vern Ruhle | Ed Figueroa | Ed Figueroa | Vern Ruhle | Tippy Martinez | 152 | 158 | -6 |
| 1976-05-29 | vs NYA | 38 | W 4-1 | 16-22 | 6 | 14,923 | Dave Roberts | Dock Ellis | Dave Roberts | Dock Ellis | | 156 | 159 | -3 |
| 1976-05-30 | vs NYA | 39 | L 0-4 | 16-23 | 6 | 16,038 | Bill Laxton | Rudy May | Rudy May | Bill Laxton | | 156 | 163 | -7 |
| 1976-05-31 | vs MIL | 40 | W 5-4 | 17-23 | 6 | 17,894 | Mark Fidrych | Jim Slaton | Mark Fidrych | Ed Sprague | | 161 | 167 | -6 |
| 1976-06-01 | vs MIL | 41 | W 8-7 | 19-23 | 5 | 0 | Ray Bare | Pete Broberg | John Hiller | Eduardo Rodriguez | | 169 | 174 | -5 |
| 1976-06-01 | vs MIL | 42 | W 6-5 | 19-23 | 5 | 12,503 | Joe Coleman | Bill Champion | John Hiller | Eduardo Rodriguez | | 175 | 179 | -4 |
| 1976-06-02 | vs MIL | 43 | W 6-4 | 20-23 | 4 | 9,283 | Vern Ruhle | Jim Colborn | Vern Ruhle | Jim Colborn | Jim Crawford | 181 | 183 | -2 |
| 1976-06-03 | vs MIL | 44 | L 2-6 | 20-24 | 5 | 10,866 | Dave Roberts | Bill Travers | Bill Travers | Dave Roberts | | 183 | 189 | -6 |
| 1976-06-04 | @ TEX | 45 | L 3-14 | 20-25 | 5 | 24,978 | Bill Laxton | Gaylord Perry | Gaylord Perry | Bill Laxton | | 186 | 203 | -17 |
| 1976-06-05 | @ TEX | 46 | W 3-2 | 21-25 | 5 | 32,678 | Mark Fidrych | Bert Blyleven | Mark Fidrych | Bert Blyleven | | 189 | 205 | -16 |
| 1976-06-06 | @ TEX | 47 | L 6-16 | 21-26 | 5 | 18,171 | Joe Coleman | Nelson Briles | Nelson Briles | Joe Coleman | | 195 | 221 | -26 |
| 1976-06-07 | @ KCA | 48 | L 0-10 | 21-27 | 5 | 18,392 | Vern Ruhle | Steve Busby | Steve Busby | Vern Ruhle | Mark Littell | 195 | 231 | -36 |
| 1976-06-08 | @ KCA | 49 | W 3-1 | 22-27 | 5 | 13,869 | Dave Roberts | Dennis Leonard | Dave Roberts | Dennis Leonard | | 198 | 232 | -34 |
| 1976-06-09 | @ KCA | 50 | L 3-6 | 22-28 | 5 | 12,529 | Ray Bare | Al Fitzmorris | Al Fitzmorris | Ray Bare | Steve Mingori | 201 | 238 | -37 |
| 1976-06-11 | vs CAL | 51 | W 4-3 | 23-28 | 5 | 36,377 | Mark Fidrych | Nolan Ryan | Mark Fidrych | Paul Hartzell | | 205 | 241 | -36 |
| 1976-06-12 | vs CAL | 52 | W 10-4 | 24-28 | 4 | 24,038 | Vern Ruhle | Gary Ross | Vern Ruhle | Gary Ross | John Hiller | 215 | 245 | -30 |
| 1976-06-13 | vs CAL | 53 | L 7-10 | 24-29 | 4 | 24,824 | Dave Roberts | Don Kirkwood | Don Kirkwood | Dave Roberts | Dick Drago | 222 | 255 | -33 |
| 1976-06-14 | vs KCA | 54 | L 2-5 | 24-30 | 4 | 16,095 | Frank MacCormack | Al Fitzmorris | Al Fitzmorris | Frank MacCormack | Tom Hall | 224 | 260 | -36 |
| 1976-06-15 | vs KCA | 55 | L 7-21 | 24-31 | 5 | 13,834 | Dave Lemanczyk | Paul Splittorff | Paul Splittorff | Dave Lemanczyk | | 231 | 281 | -50 |
| 1976-06-16 | vs KCA | 56 | W 4-3 | 25-31 | 5 | 21,659 | Mark Fidrych | Doug Bird | Mark Fidrych | Marty Pattin | | 235 | 284 | -49 |
| 1976-06-17 | @ MIN | 57 | L 0-4 | 25-32 | 5 | 5,361 | Vern Ruhle | Dave Goltz | Dave Goltz | Vern Ruhle | | 235 | 288 | -53 |
| 1976-06-18 | @ MIN | 58 | W 4-2 | 26-32 | 5 | 6,215 | Dave Roberts | Jim Hughes | Dave Roberts | Jim Hughes | | 239 | 290 | -51 |
| 1976-06-19 | @ MIN | 59 | L 4-6 | 26-33 | 5 | 6,835 | Frank MacCormack | Pete Redfern | Pete Redfern | Frank MacCormack | Bill Campbell | 243 | 296 | -53 |
| 1976-06-20 | @ MIN | 60 | W 7-3 | 27-33 | 5 | 11,916 | Mark Fidrych | Bill Singer | Mark Fidrych | Bill Singer | John Hiller | 250 | 299 | -49 |
| 1976-06-21 | @ MIL | 61 | W 3-2 | 28-33 | 5 | 10,642 | Vern Ruhle | Jim Slaton | John Hiller | Jim Slaton | | 253 | 301 | -48 |
| 1976-06-22 | @ MIL | 62 | W 10-4 | 29-33 | 5 | 13,061 | Dave Roberts | Jerry Augustine | Dave Roberts | Jerry Augustine | Steve Grilli | 263 | 305 | -42 |
| 1976-06-23 | @ MIL | 63 | L 5-9 | 29-34 | 5 | 9,807 | Frank MacCormack | Jim Colborn | Jim Colborn | Frank MacCormack | | 268 | 314 | -46 |
| 1976-06-24 | @ BOS | 64 | W 6-3 | 30-34 | 5 | 26,293 | Mark Fidrych | Rick Wise | Mark Fidrych | Rick Wise | | 274 | 317 | -43 |
| 1976-06-25 | @ BOS | 65 | W 6-2 | 31-34 | 4 | 27,942 | Vern Ruhle | Fergie Jenkins | John Hiller | Fergie Jenkins | | 280 | 319 | -39 |
| 1976-06-26 | @ BOS | 66 | L 1-2 | 31-35 | 5 | 28,520 | Dave Roberts | Luis Tiant | Luis Tiant | Dave Roberts | | 281 | 321 | -40 |
| 1976-06-27 | @ BOS | 67 | W 4-2 | 32-35 | 4 | 29,809 | Frank MacCormack | Dick Pole | Steve Grilli | Tom Murphy | | 285 | 323 | -38 |
| 1976-06-28 | vs NYA | 68 | W 5-1 | 33-35 | 4 | 47,855 | Mark Fidrych | Ken Holtzman | Mark Fidrych | Ken Holtzman | | 290 | 324 | -34 |
| 1976-06-29 | vs NYA | 69 | W 7-5 | 34-35 | 3 | 21,350 | Jim Crawford | Doyle Alexander | Dave Lemanczyk | Sparky Lyle | John Hiller | 297 | 329 | -32 |
| 1976-07-01 | @ BAL | 70 | W 2-0 | 35-35 | 3 | 8,746 | Dave Roberts | Rudy May | Dave Roberts | Rudy May | | 299 | 329 | -30 |
| 1976-07-02 | @ BAL | 71 | L 1-2 | 35-36 | 4 | 32,338 | Vern Ruhle | Jim Palmer | Jim Palmer | Vern Ruhle | | 300 | 331 | -31 |
| 1976-07-03 | vs BAL | 72 | W 4-0 | 36-36 | 3 | 51,032 | Mark Fidrych | Mike Cuellar | Mark Fidrych | Mike Cuellar | | 304 | 331 | -27 |
| 1976-07-04 | vs BAL | 73 | L 4-7 | 36-37 | 4 | 14,454 | Frank MacCormack | Wayne Garland | Wayne Garland | John Hiller | | 308 | 338 | -30 |
| 1976-07-05 | @ TEX | 74 | L 6-8 | 36-38 | 4 | 33,847 | Dave Roberts | Gaylord Perry | Jeff Terpko | Dave Roberts | | 314 | 346 | -32 |
| 1976-07-06 | @ TEX | 75 | L 2-3 | 36-39 | 4 | 15,873 | Vern Ruhle | Steve Barr | Steve Barr | Vern Ruhle | | 316 | 349 | -33 |
| 1976-07-07 | @ TEX | 76 | W 2-1 | 37-39 | 4 | 20,052 | Dave Lemanczyk | Bert Blyleven | John Hiller | Bert Blyleven | Steve Grilli | 318 | 350 | -32 |
| 1976-07-09 | vs KCA | 77 | L 0-1 | 37-40 | 4 | 51,041 | Mark Fidrych | Dennis Leonard | Dennis Leonard | Mark Fidrych | | 318 | 351 | -33 |
| 1976-07-10 | vs KCA | 78 | L 1-7 | 37-41 | 5 | 27,630 | Dave Roberts | Al Fitzmorris | Al Fitzmorris | Dave Roberts | Mark Littell | 319 | 358 | -39 |
| 1976-07-11 | vs KCA | 79 | W 6-5 | 38-41 | 5 | 21,764 | Vern Ruhle | Paul Splittorff | John Hiller | Steve Mingori | | 325 | 363 | -38 |
| 1976-07-15 | vs OAK | 80 | W 3-2 | 39-41 | 4 | 14,835 | Dave Roberts | Vida Blue | Dave Roberts | Vida Blue | | 328 | 365 | -37 |
| 1976-07-16 | vs OAK | 81 | W 1-0 | 40-41 | 3 | 45,905 | Mark Fidrych | Mike Torrez | Mark Fidrych | Rollie Fingers | | 329 | 365 | -36 |
| 1976-07-17 | vs OAK | 82 | L 0-3 | 40-42 | 4 | 30,110 | Vern Ruhle | Mike Norris | Mike Norris | Vern Ruhle | Rollie Fingers | 329 | 368 | -39 |
| 1976-07-18 | vs OAK | 83 | L 1-10 | 40-43 | 4 | 23,841 | Frank MacCormack | Paul Mitchell | Paul Mitchell | Frank MacCormack | | 330 | 378 | -48 |
| 1976-07-19 | @ MIN | 84 | L 5-6 | 40-44 | 4 | 5,005 | Dave Roberts | Eddie Bane | Bill Campbell | Dave Roberts | | 335 | 384 | -49 |
| 1976-07-20 | @ MIN | 85 | W 8-3 | 41-44 | 4 | 30,425 | Mark Fidrych | Bill Singer | Mark Fidrych | Bill Singer | | 343 | 387 | -44 |
| 1976-07-21 | @ CHA | 86 | L 1-4 | 41-46 | 5 | 0 | Vern Ruhle | Chris Knapp | Chris Knapp | Vern Ruhle | | 344 | 391 | -47 |
| 1976-07-21 | @ CHA | 87 | L 0-3 | 41-46 | 5 | 10,765 | Dave Lemanczyk | Bart Johnson | Bart Johnson | Dave Lemanczyk | | 344 | 394 | -50 |
| 1976-07-22 | @ CHA | 88 | L 3-9 | 42-47 | 4 | 0 | Frank MacCormack | Blue Moon Odom | Blue Moon Odom | Frank MacCormack | | 347 | 403 | -56 |
| 1976-07-22 | @ CHA | 89 | W 5-1 | 42-47 | 4 | 9,077 | Ray Bare | Rich Gossage | Ray Bare | Rich Gossage | John Hiller | 352 | 404 | -52 |
| 1976-07-23 | @ CLE | 90 | L 4-9 | 42-48 | 4 | 13,273 | Dave Roberts | Jim Bibby | Jim Bibby | Dave Roberts | Tom Buskey | 356 | 413 | -57 |
| 1976-07-24 | @ CLE | 91 | W 5-4 | 43-48 | 4 | 37,405 | Mark Fidrych | Jackie Brown | John Hiller | Jim Kern | | 361 | 417 | -56 |
| 1976-07-25 | @ CLE | 92 | W 9-1 | 45-48 | 4 | 0 | Vern Ruhle | Pat Dobson | Vern Ruhle | Pat Dobson | | 370 | 418 | -48 |
| 1976-07-25 | @ CLE | 93 | W 5-4 | 45-48 | 4 | 34,604 | Dave Lemanczyk | Rick Waits | Dave Lemanczyk | Rick Waits | John Hiller | 375 | 422 | -47 |
| 1976-07-26 | @ MIL | 94 | W 4-3 | 46-48 | 4 | 9,729 | Frank MacCormack | Jim Colborn | John Hiller | Danny Frisella | | 379 | 425 | -46 |
| 1976-07-27 | @ MIL | 95 | L 4-6 | 46-49 | 4 | 14,020 | Ray Bare | Jim Slaton | Jim Slaton | Ray Bare | Bill Castro | 383 | 431 | -48 |
| 1976-07-28 | @ MIL | 96 | W 1-0 | 47-49 | 4 | 13,865 | Dave Roberts | Jerry Augustine | Dave Roberts | Jerry Augustine | | 384 | 431 | -47 |
| 1976-07-29 | vs BAL | 97 | L 0-1 | 47-50 | 4 | 44,068 | Mark Fidrych | Rudy May | Rudy May | Mark Fidrych | | 384 | 432 | -48 |
| 1976-07-30 | vs BAL | 98 | L 3-7 | 47-51 | 4 | 22,553 | Vern Ruhle | Ross Grimsley | Ross Grimsley | Vern Ruhle | | 387 | 439 | -52 |
| 1976-07-31 | @ BAL | 99 | W 5-4 | 48-51 | 4 | 31,425 | Dave Lemanczyk | Jim Palmer | Dave Lemanczyk | Jim Palmer | John Hiller | 392 | 443 | -51 |
| 1976-08-01 | @ BAL | 100 | L 3-4 | 48-52 | 4 | 9,953 | Ray Bare | Wayne Garland | Fred Holdsworth | John Hiller | | 395 | 447 | -52 |
| 1976-08-02 | @ NYA | 101 | L 0-1 | 48-53 | 4 | 22,245 | Dave Roberts | Doyle Alexander | Doyle Alexander | Dave Roberts | | 395 | 448 | -53 |
| 1976-08-03 | @ NYA | 102 | L 3-4 | 48-54 | 4 | 44,909 | Mark Fidrych | Ed Figueroa | Grant Jackson | Mark Fidrych | | 398 | 452 | -54 |
| 1976-08-04 | vs BOS | 103 | L 1-4 | 48-55 | 5 | 14,924 | Vern Ruhle | Fergie Jenkins | Fergie Jenkins | Vern Ruhle | | 399 | 456 | -57 |
| 1976-08-05 | vs BOS | 104 | L 4-5 | 48-56 | 5 | 14,419 | Dave Lemanczyk | Rick Jones | Reggie Cleveland | Dave Lemanczyk | Bill Lee | 403 | 461 | -58 |
| 1976-08-06 | vs CLE | 105 | W 3-1 | 49-56 | 5 | 19,079 | Dave Roberts | Jackie Brown | Dave Roberts | Jackie Brown | | 406 | 462 | -56 |
| 1976-08-07 | vs CLE | 106 | W 6-1 | 50-56 | 5 | 35,395 | Mark Fidrych | Pat Dobson | Mark Fidrych | Pat Dobson | | 412 | 463 | -51 |
| 1976-08-08 | vs CLE | 107 | W 2-1 | 52-56 | 5 | 0 | Vern Ruhle | Dennis Eckersley | John Hiller | Dennis Eckersley | | 414 | 464 | -50 |
| 1976-08-08 | vs CLE | 108 | W 15-5 | 52-56 | 5 | 26,447 | Ray Bare | Rick Waits | Steve Grilli | Jim Kern | | 429 | 469 | -40 |
| 1976-08-09 | vs TEX | 109 | L 1-8 | 52-57 | 5 | 14,963 | Dave Lemanczyk | Nelson Briles | Nelson Briles | Dave Lemanczyk | | 430 | 477 | -47 |
| 1976-08-10 | vs TEX | 110 | W 7-5 | 53-58 | 5 | 0 | Dave Roberts | Bert Blyleven | Dave Lemanczyk | Jeff Terpko | | 437 | 482 | -45 |
| 1976-08-10 | vs TEX | 111 | L 0-3 | 53-58 | 5 | 15,028 | Jim Crawford | Steve Hargan | Steve Hargan | Jim Crawford | | 437 | 485 | -48 |
| 1976-08-11 | vs TEX | 112 | W 4-3 | 54-58 | 4 | 36,523 | Mark Fidrych | Gaylord Perry | Mark Fidrych | Gaylord Perry | | 441 | 488 | -47 |
| 1976-08-13 | @ KCA | 113 | W 3-2 | 55-58 | 4 | 25,215 | Vern Ruhle | Al Fitzmorris | Vern Ruhle | Al Fitzmorris | John Hiller | 444 | 490 | -46 |
| 1976-08-14 | @ KCA | 114 | L 3-15 | 55-59 | 4 | 27,333 | Dave Lemanczyk | Dennis Leonard | Dennis Leonard | Dave Lemanczyk | | 447 | 505 | -58 |
| 1976-08-15 | @ KCA | 115 | L 3-7 | 55-60 | 4 | 30,720 | Dave Roberts | Andy Hassler | Andy Hassler | Dave Roberts | | 450 | 512 | -62 |
| 1976-08-17 | vs CAL | 116 | W 3-2 | 56-60 | 4 | 51,822 | Mark Fidrych | Frank Tanana | Mark Fidrych | Frank Tanana | | 453 | 514 | -61 |
| 1976-08-18 | vs CAL | 117 | L 4-5 | 56-61 | 4 | 10,104 | Vern Ruhle | Nolan Ryan | Nolan Ryan | John Hiller | John Verhoeven | 457 | 519 | -62 |
| 1976-08-19 | vs CAL | 118 | W 4-3 | 57-61 | 4 | 8,141 | Ray Bare | Paul Hartzell | Ray Bare | Paul Hartzell | Jim Crawford | 461 | 522 | -61 |
| 1976-08-20 | vs MIN | 119 | W 3-2 | 58-62 | 4 | 0 | Dave Roberts | Eddie Bane | Dave Roberts | Eddie Bane | | 464 | 524 | -60 |
| 1976-08-20 | vs MIN | 120 | L 5-8 | 58-62 | 4 | 17,385 | Dave Lemanczyk | Steve Luebber | Tom Burgmeier | Bill Laxton | Bill Campbell | 469 | 532 | -63 |
| 1976-08-21 | vs MIN | 121 | L 3-7 | 58-63 | 4 | 34,760 | Mark Fidrych | Pete Redfern | Jim Hughes | Mark Fidrych | | 472 | 539 | -67 |
| 1976-08-22 | vs MIN | 122 | L 4-6 | 58-64 | 4 | 14,979 | Vern Ruhle | Dave Goltz | Bill Campbell | John Hiller | | 476 | 545 | -69 |
| 1976-08-23 | vs CHA | 123 | W 5-4 | 59-64 | 4 | 13,426 | Ray Bare | Rich Gossage | Ray Bare | Rich Gossage | | 481 | 549 | -68 |
| 1976-08-24 | vs CHA | 124 | L 7-12 | 59-65 | 4 | 9,503 | Dave Roberts | Ken Brett | Dave Hamilton | Jim Crawford | | 488 | 561 | -73 |
| 1976-08-25 | vs CHA | 125 | W 3-1 | 60-65 | 4 | 39,884 | Mark Fidrych | Bart Johnson | Mark Fidrych | Bart Johnson | | 491 | 562 | -71 |
| 1976-08-27 | @ OAK | 126 | W 8-1 | 61-65 | 4 | 5,884 | Vern Ruhle | Glenn Abbott | Vern Ruhle | Glenn Abbott | | 499 | 563 | -64 |
| 1976-08-28 | @ OAK | 127 | L 2-5 | 61-66 | 4 | 9,252 | Dave Roberts | Vida Blue | Vida Blue | Dave Roberts | | 501 | 568 | -67 |
| 1976-08-29 | @ OAK | 128 | L 1-2 | 61-67 | 5 | 25,659 | Mark Fidrych | Mike Torrez | Rollie Fingers | Mark Fidrych | | 502 | 570 | -68 |
| 1976-08-30 | @ CAL | 129 | L 1-2 | 61-68 | 5 | 16,924 | Ray Bare | Paul Hartzell | Paul Hartzell | Jim Crawford | | 503 | 572 | -69 |
| 1976-08-31 | @ CAL | 130 | L 3-6 | 61-69 | 5 | 8,542 | Vern Ruhle | Nolan Ryan | Nolan Ryan | Vern Ruhle | | 506 | 578 | -72 |
| 1976-09-01 | @ CAL | 131 | L 1-4 | 61-70 | 5 | 10,720 | Dave Roberts | Frank Tanana | Frank Tanana | Dave Roberts | | 507 | 582 | -75 |
| 1976-09-03 | vs MIL | 132 | L 2-11 | 61-71 | 5 | 32,951 | Mark Fidrych | Jerry Augustine | Jerry Augustine | Mark Fidrych | | 509 | 593 | -84 |
| 1976-09-04 | vs MIL | 133 | W 4-0 | 62-71 | 5 | 10,303 | Vern Ruhle | Bill Travers | Vern Ruhle | Bill Travers | | 513 | 593 | -80 |
| 1976-09-05 | vs MIL | 134 | L 6-8 | 62-72 | 5 | 9,896 | Ray Bare | Jim Slaton | Ray Sadecki | Ray Bare | Danny Frisella | 519 | 601 | -82 |
| 1976-09-06 | vs BAL | 135 | W 5-4 | 63-72 | 5 | 8,204 | Dave Roberts | Mike Flanagan | Dave Roberts | Dyar Miller | | 524 | 605 | -81 |
| 1976-09-07 | vs BAL | 136 | L 3-5 | 63-73 | 5 | 16,410 | Mark Fidrych | Wayne Garland | Wayne Garland | Mark Fidrych | | 527 | 610 | -83 |
| 1976-09-08 | @ BOS | 137 | L 3-4 | 63-74 | 5 | 13,966 | Dave Lemanczyk | Bill Lee | Bill Lee | Dave Lemanczyk | Jim Willoughby | 530 | 614 | -84 |
| 1976-09-09 | @ BOS | 138 | L 0-5 | 63-75 | 5 | 13,643 | Vern Ruhle | Rick Wise | Rick Wise | Vern Ruhle | | 530 | 619 | -89 |
| 1976-09-10 | @ BOS | 139 | W 1-0 | 64-75 | 5 | 19,192 | Ray Bare | Reggie Cleveland | Ray Bare | Reggie Cleveland | | 531 | 619 | -88 |
| 1976-09-11 | @ NYA | 140 | W 6-5 | 65-75 | 5 | 31,122 | Dave Roberts | Doyle Alexander | Dave Roberts | Doyle Alexander | John Hiller | 537 | 624 | -87 |
| 1976-09-12 | @ NYA | 141 | W 6-0 | 66-76 | 5 | 0 | Mark Fidrych | Dock Ellis | Mark Fidrych | Dock Ellis | | 543 | 624 | -81 |
| 1976-09-12 | @ NYA | 142 | L 1-3 | 66-76 | 5 | 52,707 | Ed Glynn | Ed Figueroa | Ed Figueroa | Ed Glynn | | 544 | 627 | -83 |
| 1976-09-13 | @ NYA | 143 | W 3-1 | 67-76 | 5 | 11,723 | Jim Crawford | Ken Holtzman | Jim Crawford | Ken Holtzman | John Hiller | 547 | 628 | -81 |
| 1976-09-14 | @ BAL | 144 | L 7-9 | 67-77 | 5 | 4,516 | Vern Ruhle | Ross Grimsley | Dennis Martinez | John Hiller | | 554 | 637 | -83 |
| 1976-09-15 | @ BAL | 145 | L 0-1 | 67-78 | 5 | 2,721 | Dave Roberts | Wayne Garland | Wayne Garland | Dave Roberts | | 554 | 638 | -84 |
| 1976-09-17 | vs BOS | 146 | L 3-8 | 67-79 | 5 | 20,371 | Mark Fidrych | Luis Tiant | Luis Tiant | Mark Fidrych | | 557 | 646 | -89 |
| 1976-09-18 | vs BOS | 147 | L 4-5 | 67-80 | 5 | 12,156 | Vern Ruhle | Bill Lee | Bill Lee | Vern Ruhle | Tom Murphy | 561 | 651 | -90 |
| 1976-09-19 | vs BOS | 148 | L 1-6 | 67-81 | 5 | 8,949 | Dave Roberts | Rick Wise | Rick Wise | Dave Roberts | | 562 | 657 | -95 |
| 1976-09-20 | vs BOS | 149 | L 6-12 | 67-82 | 5 | 5,328 | Ed Glynn | Reggie Cleveland | Rick Jones | Ed Glynn | | 568 | 669 | -101 |
| 1976-09-21 | vs CLE | 150 | W 5-3 | 68-82 | 5 | 7,147 | Mark Fidrych | Rick Waits | Mark Fidrych | Rick Waits | | 573 | 672 | -99 |
| 1976-09-22 | vs CLE | 151 | L 0-3 | 68-83 | 5 | 3,616 | Ray Bare | Jim Bibby | Jim Bibby | Ray Bare | | 573 | 675 | -102 |
| 1976-09-24 | vs NYA | 152 | W 3-0 | 69-84 | 5 | 0 | Dave Roberts | Ken Holtzman | Dave Roberts | Ken Holtzman | | 576 | 675 | -99 |
| 1976-09-24 | vs NYA | 153 | L 0-8 | 69-84 | 5 | 10,522 | Jim Crawford | Grant Jackson | Grant Jackson | Jim Crawford | | 576 | 683 | -107 |
| 1976-09-25 | vs NYA | 154 | L 6-10 | 69-85 | 5 | 12,814 | Ed Glynn | Doyle Alexander | Doyle Alexander | Ed Glynn | Dick Tidrow | 582 | 693 | -111 |
| 1976-09-28 | @ CLE | 155 | W 4-0 | 70-86 | 5 | 0 | Mark Fidrych | Jim Bibby | Mark Fidrych | Jim Bibby | | 586 | 693 | -107 |
| 1976-09-28 | @ CLE | 156 | L 1-6 | 70-86 | 5 | 3,394 | Dave Roberts | Dennis Eckersley | Dennis Eckersley | Dave Roberts | | 587 | 699 | -112 |
| 1976-09-29 | @ CLE | 157 | L 2-3 | 70-87 | 5 | 2,867 | Jim Crawford | Pat Dobson | Jackie Brown | Jim Crawford | Dave LaRoche | 589 | 702 | -113 |
| 1976-09-30 | @ CLE | 158 | W 6-4 | 71-87 | 5 | 4,083 | Ed Glynn | Rick Waits | Ed Glynn | Rick Waits | Steve Grilli | 595 | 706 | -111 |
| 1976-10-01 | @ MIL | 159 | W 5-0 | 72-87 | 5 | 6,065 | John Hiller | Bill Travers | John Hiller | Bill Travers | | 600 | 706 | -106 |
| 1976-10-02 | @ MIL | 160 | W 4-1 | 73-87 | 5 | 9,044 | Mark Fidrych | Jim Slaton | Mark Fidrych | Jim Slaton | | 604 | 707 | -103 |
| 1976-10-03 | @ MIL | 161 | W 5-2 | 74-87 | 5 | 6,858 | Dave Roberts | Gary Beare | Dave Roberts | Gary Beare | | 609 | 709 | -100 |