| 1975-04-07 | vs LAN | 1 | W 2-1 | 1-0 | 1 | 52,526 | Don Gullett | Don Sutton | Pat Darcy | Charlie Hough | | 2 | 1 | 1 |
| 1975-04-09 | vs LAN | 2 | W 4-3 | 2-0 | 1 | 15,554 | Jack Billingham | Andy Messersmith | Pedro Borbon | Mike Marshall | | 6 | 4 | 2 |
| 1975-04-10 | vs LAN | 3 | W 7-6 | 3-0 | 1 | 20,550 | Clay Kirby | Doug Rau | Clay Carroll | Charlie Hough | | 13 | 10 | 3 |
| 1975-04-11 | @ SDN | 4 | L 2-5 | 3-1 | 1 | 13,818 | Fred Norman | Dan Spillner | Dan Spillner | Fred Norman | | 15 | 15 | 0 |
| 1975-04-12 | @ SDN | 5 | L 2-3 | 3-2 | 3 | 17,881 | Gary Nolan | Joe McIntosh | Joe McIntosh | Gary Nolan | Bill Greif | 17 | 18 | -1 |
| 1975-04-13 | @ SDN | 6 | W 10-0 | 4-2 | 1 | 17,622 | Don Gullett | Dave Freisleben | Don Gullett | Dave Freisleben | | 27 | 18 | 9 |
| 1975-04-14 | @ LAN | 7 | L 2-5 | 4-3 | 2 | 45,502 | Jack Billingham | Doug Rau | Doug Rau | Jack Billingham | Mike Marshall | 29 | 23 | 6 |
| 1975-04-15 | @ LAN | 8 | L 1-3 | 4-4 | 3 | 31,663 | Clay Kirby | Don Sutton | Don Sutton | Clay Kirby | | 30 | 26 | 4 |
| 1975-04-16 | @ LAN | 9 | L 6-7 | 4-5 | 5 | 36,578 | Fred Norman | Juan Marichal | Mike Marshall | Clay Carroll | | 36 | 33 | 3 |
| 1975-04-17 | @ LAN | 10 | L 4-5 | 4-6 | 5 | 27,835 | Gary Nolan | Andy Messersmith | Mike Marshall | Clay Carroll | | 40 | 38 | 2 |
| 1975-04-18 | vs HOU | 11 | W 5-2 | 5-6 | 5 | 36,485 | Don Gullett | Tom Griffin | Don Gullett | Tom Griffin | | 45 | 40 | 5 |
| 1975-04-19 | vs HOU | 12 | W 9-8 | 6-6 | 4 | 17,178 | Jack Billingham | Doug Konieczny | Clay Carroll | Ken Forsch | | 54 | 48 | 6 |
| 1975-04-20 | vs HOU | 13 | W 5-3 | 7-7 | 5 | 0 | Pat Darcy | Larry Dierker | Clay Carroll | Fred Scherman | | 59 | 51 | 8 |
| 1975-04-20 | vs HOU | 14 | L 6-7 | 7-7 | 5 | 35,150 | Clay Kirby | J.R. Richard | J.R. Richard | Clay Kirby | Wayne Granger | 65 | 58 | 7 |
| 1975-04-21 | vs SFN | 15 | L 3-4 | 7-8 | 5 | 12,397 | Fred Norman | Mike Caldwell | Gary Lavelle | Pedro Borbon | | 68 | 62 | 6 |
| 1975-04-22 | vs SFN | 16 | W 5-4 | 8-8 | 5 | 14,235 | Gary Nolan | John D'Acquisto | Clay Kirby | Charlie Williams | | 73 | 66 | 7 |
| 1975-04-23 | @ ATL | 17 | L 4-5 | 8-9 | 5 | 7,234 | Don Gullett | Ron Reed | Ron Reed | Don Gullett | | 77 | 71 | 6 |
| 1975-04-24 | @ ATL | 18 | W 11-3 | 9-9 | 5 | 8,266 | Jack Billingham | Phil Niekro | Jack Billingham | Phil Niekro | | 88 | 74 | 14 |
| 1975-04-25 | @ HOU | 19 | L 4-6 | 9-10 | 5 | 11,162 | Pat Darcy | Larry Dierker | Larry Dierker | Pat Darcy | Ken Forsch | 92 | 80 | 12 |
| 1975-04-26 | @ HOU | 20 | W 9-3 | 10-10 | 4 | 14,889 | Fred Norman | Tom Griffin | Fred Norman | Tom Griffin | | 101 | 83 | 18 |
| 1975-04-27 | @ HOU | 21 | W 6-2 | 11-10 | 4 | 11,140 | Gary Nolan | Doug Konieczny | Pedro Borbon | Doug Konieczny | | 107 | 85 | 22 |
| 1975-04-29 | @ SFN | 22 | L 3-4 | 11-11 | 3 | 4,609 | Don Gullett | Pete Falcone | Randy Moffitt | Clay Carroll | | 110 | 89 | 21 |
| 1975-04-30 | @ SFN | 23 | W 4-1 | 12-11 | 3 | 4,340 | Jack Billingham | Jim Barr | Jack Billingham | Jim Barr | Will McEnaney | 114 | 90 | 24 |
| 1975-05-02 | vs ATL | 24 | L 5-6 | 12-12 | 3 | 21,061 | Fred Norman | Ron Reed | Gary Gentry | Clay Kirby | Tom House | 119 | 96 | 23 |
| 1975-05-03 | vs ATL | 25 | W 6-1 | 13-12 | 2 | 27,091 | Gary Nolan | Roric Harrison | Gary Nolan | Roric Harrison | | 125 | 97 | 28 |
| 1975-05-04 | vs ATL | 26 | W 3-2 | 14-12 | 2 | 51,030 | Don Gullett | Phil Niekro | Don Gullett | Phil Niekro | Pedro Borbon | 128 | 99 | 29 |
| 1975-05-06 | vs SDN | 27 | W 7-3 | 15-12 | 2 | 11,933 | Jack Billingham | Sonny Siebert | Jack Billingham | Sonny Siebert | | 135 | 102 | 33 |
| 1975-05-07 | vs SDN | 28 | W 10-2 | 16-12 | 2 | 16,931 | Fred Norman | Dan Spillner | Fred Norman | Dan Spillner | Clay Carroll | 145 | 104 | 41 |
| 1975-05-08 | vs SDN | 29 | L 0-3 | 16-13 | 2 | 14,192 | Gary Nolan | Randy Jones | Randy Jones | Gary Nolan | | 145 | 107 | 38 |
| 1975-05-09 | @ NYN | 30 | W 4-3 | 17-13 | 2 | 21,731 | Don Gullett | Randy Tate | Don Gullett | Randy Tate | Clay Carroll | 149 | 110 | 39 |
| 1975-05-10 | @ NYN | 31 | W 7-1 | 18-13 | 2 | 21,405 | Clay Kirby | Hank Webb | Clay Kirby | Hank Webb | Will McEnaney | 156 | 111 | 45 |
| 1975-05-11 | @ NYN | 32 | L 2-3 | 18-14 | 2 | 26,237 | Jack Billingham | Tom Seaver | Tom Seaver | Jack Billingham | | 158 | 114 | 44 |
| 1975-05-13 | @ PHI | 33 | L 0-4 | 18-15 | 2 | 11,634 | Gary Nolan | Tom Underwood | Tom Underwood | Gary Nolan | | 158 | 118 | 40 |
| 1975-05-14 | @ PHI | 34 | L 0-4 | 18-16 | 2 | 30,908 | Pat Darcy | Steve Carlton | Steve Carlton | Pat Darcy | | 158 | 122 | 36 |
| 1975-05-15 | @ PHI | 35 | L 3-6 | 18-18 | 3 | 0 | Don Gullett | Jim Lonborg | Tug McGraw | Don Gullett | | 161 | 128 | 33 |
| 1975-05-15 | @ PHI | 36 | L 3-5 | 18-18 | 3 | 24,038 | Clay Kirby | Wayne Twitchell | Gene Garber | Clay Carroll | Tug McGraw | 164 | 133 | 31 |
| 1975-05-16 | @ MON | 37 | L 2-4 | 18-19 | 3 | 11,136 | Jack Billingham | Dennis Blair | Dennis Blair | Jack Billingham | Chuck Taylor | 166 | 137 | 29 |
| 1975-05-17 | @ MON | 38 | W 5-3 | 19-19 | 2 | 18,142 | Fred Norman | Steve Rogers | Will McEnaney | John Montague | | 171 | 140 | 31 |
| 1975-05-18 | @ MON | 39 | W 6-1 | 20-19 | 2 | 16,130 | Gary Nolan | Dave McNally | Gary Nolan | Dave McNally | | 177 | 141 | 36 |
| 1975-05-20 | vs NYN | 40 | L 2-6 | 20-20 | 2 | 16,845 | Don Gullett | Jerry Koosman | Jerry Koosman | Don Gullett | Bob Apodaca | 179 | 147 | 32 |
| 1975-05-21 | vs NYN | 41 | W 11-4 | 21-20 | 3 | 16,072 | Jack Billingham | Tom Seaver | Jack Billingham | Tom Seaver | | 190 | 151 | 39 |
| 1975-05-23 | vs PHI | 42 | W 5-2 | 22-20 | 2 | 36,197 | Gary Nolan | Larry Christenson | Gary Nolan | Larry Christenson | Clay Carroll | 195 | 153 | 42 |
| 1975-05-24 | vs PHI | 43 | W 3-2 | 23-20 | 2 | 36,165 | Pat Darcy | Steve Carlton | Clay Carroll | Tug McGraw | | 198 | 155 | 43 |
| 1975-05-25 | vs PHI | 44 | W 4-3 | 24-20 | 2 | 25,726 | Clay Kirby | Jim Lonborg | Clay Kirby | Jim Lonborg | Rawly Eastwick | 202 | 158 | 44 |
| 1975-05-26 | vs MON | 45 | W 4-3 | 26-20 | 2 | 0 | Jack Billingham | Woodie Fryman | Clay Carroll | Woodie Fryman | Will McEnaney | 206 | 161 | 45 |
| 1975-05-26 | vs MON | 46 | W 5-4 | 26-20 | 2 | 25,034 | Don Gullett | Steve Renko | Don Gullett | Steve Renko | Rawly Eastwick | 211 | 165 | 46 |
| 1975-05-28 | vs MON | 47 | W 6-0 | 27-20 | 2 | 16,480 | Gary Nolan | Dennis Blair | Gary Nolan | Dennis Blair | | 217 | 165 | 52 |
| 1975-05-30 | @ SLN | 48 | L 4-5 | 27-21 | 2 | 21,930 | Clay Kirby | John Curtis | Al Hrabosky | Rawly Eastwick | | 221 | 170 | 51 |
| 1975-05-31 | @ SLN | 49 | W 6-0 | 28-21 | 2 | 28,475 | Don Gullett | Bob Gibson | Don Gullett | Bob Gibson | | 227 | 170 | 57 |
| 1975-06-01 | @ SLN | 50 | W 5-1 | 29-21 | 2 | 25,231 | Jack Billingham | Bob Forsch | Jack Billingham | Bob Forsch | | 232 | 171 | 61 |
| 1975-06-03 | @ PIT | 51 | W 8-4 | 30-21 | 1 | 9,438 | Gary Nolan | Bob Moose | Gary Nolan | Bob Moose | | 240 | 175 | 65 |
| 1975-06-04 | @ PIT | 52 | L 1-2 | 30-22 | 2 | 13,754 | Fred Norman | Jerry Reuss | Jerry Reuss | Fred Norman | Ramon Hernandez | 241 | 177 | 64 |
| 1975-06-06 | vs CHN | 53 | W 5-1 | 31-22 | 2 | 38,030 | Don Gullett | Bill Bonham | Don Gullett | Bill Bonham | | 246 | 178 | 68 |
| 1975-06-07 | vs CHN | 54 | W 8-1 | 32-22 | 1 | 47,340 | Jack Billingham | Ray Burris | Jack Billingham | Ray Burris | | 254 | 179 | 75 |
| 1975-06-08 | vs CHN | 55 | W 2-1 | 34-22 | 1 | 0 | Gary Nolan | Rick Reuschel | Gary Nolan | Rick Reuschel | | 256 | 180 | 76 |
| 1975-06-08 | vs CHN | 56 | W 8-5 | 34-22 | 1 | 50,311 | Clay Kirby | Geoff Zahn | Pedro Borbon | Geoff Zahn | Will McEnaney | 264 | 185 | 79 |
| 1975-06-09 | vs PIT | 57 | L 2-9 | 34-23 | 1 | 22,555 | Fred Norman | Jerry Reuss | Jerry Reuss | Fred Norman | | 266 | 194 | 72 |
| 1975-06-10 | vs PIT | 58 | L 5-9 | 34-24 | 1 | 19,107 | Pat Darcy | Sam McDowell | Sam McDowell | Pat Darcy | Ramon Hernandez | 271 | 203 | 68 |
| 1975-06-11 | vs SLN | 59 | W 3-1 | 35-24 | 1 | 22,103 | Don Gullett | Bob Forsch | Don Gullett | Bob Forsch | | 274 | 204 | 70 |
| 1975-06-12 | vs SLN | 60 | W 10-1 | 36-24 | 1 | 24,512 | Gary Nolan | Lynn McGlothen | Gary Nolan | Lynn McGlothen | | 284 | 205 | 79 |
| 1975-06-13 | @ CHN | 61 | W 18-11 | 37-24 | 1 | 17,488 | Jack Billingham | Rick Reuschel | Pedro Borbon | Oscar Zamora | | 302 | 216 | 86 |
| 1975-06-14 | @ CHN | 62 | W 11-3 | 38-24 | 1 | 28,134 | Clay Kirby | Steve Stone | Clay Kirby | Steve Stone | | 313 | 219 | 94 |
| 1975-06-15 | @ CHN | 63 | L 3-4 | 38-25 | 1 | 18,575 | Pat Darcy | Bill Bonham | Bill Bonham | Pat Darcy | Oscar Zamora | 316 | 223 | 93 |
| 1975-06-16 | vs ATL | 64 | W 9-2 | 39-25 | 1 | 20,642 | Don Gullett | Phil Niekro | Don Gullett | Phil Niekro | | 325 | 225 | 100 |
| 1975-06-17 | vs ATL | 65 | L 1-5 | 39-26 | 1 | 22,133 | Gary Nolan | Carl Morton | Carl Morton | Gary Nolan | | 326 | 230 | 96 |
| 1975-06-18 | vs ATL | 66 | W 6-1 | 40-26 | 1 | 30,333 | Jack Billingham | Blue Moon Odom | Jack Billingham | Blue Moon Odom | Will McEnaney | 332 | 231 | 101 |
| 1975-06-20 | @ HOU | 67 | W 7-3 | 41-26 | 1 | 19,357 | Tom Carroll | Doug Konieczny | Tom Carroll | Doug Konieczny | | 339 | 234 | 105 |
| 1975-06-21 | @ HOU | 68 | W 7-6 | 42-26 | 1 | 24,317 | Clay Carroll | J.R. Richard | Fred Norman | Joe Niekro | | 346 | 240 | 106 |
| 1975-06-22 | @ HOU | 69 | L 4-8 | 42-27 | 1 | 18,871 | Gary Nolan | Larry Dierker | Larry Dierker | Gary Nolan | | 350 | 248 | 102 |
| 1975-06-23 | @ ATL | 70 | W 8-4 | 43-27 | 1 | 8,537 | Jack Billingham | Jamie Easterly | Jack Billingham | Jamie Easterly | | 358 | 252 | 106 |
| 1975-06-24 | @ ATL | 71 | W 3-0 | 44-27 | 1 | 9,148 | Pat Darcy | Phil Niekro | Pat Darcy | Phil Niekro | Pedro Borbon | 361 | 252 | 109 |
| 1975-06-25 | @ ATL | 72 | W 2-0 | 45-27 | 1 | 8,117 | Tom Carroll | Carl Morton | Tom Carroll | Carl Morton | Will McEnaney | 363 | 252 | 111 |
| 1975-06-27 | vs SDN | 73 | W 5-2 | 46-27 | 1 | 31,076 | Clay Carroll | Dave Freisleben | Will McEnaney | Danny Frisella | | 368 | 254 | 114 |
| 1975-06-28 | vs SDN | 74 | W 6-4 | 47-27 | 1 | 48,747 | Gary Nolan | Joe McIntosh | Will McEnaney | Dave Tomlin | | 374 | 258 | 116 |
| 1975-06-29 | vs SDN | 75 | W 4-1 | 48-28 | 1 | 0 | Jack Billingham | Randy Jones | Jack Billingham | Randy Jones | Will McEnaney | 378 | 259 | 119 |
| 1975-06-29 | vs SDN | 76 | L 3-4 | 48-28 | 1 | 46,060 | Pat Darcy | Brent Strom | Brent Strom | Pat Darcy | | 381 | 263 | 118 |
| 1975-06-30 | vs HOU | 77 | W 9-6 | 49-28 | 1 | 22,708 | Tom Carroll | Doug Konieczny | Clay Kirby | Joe Niekro | | 390 | 269 | 121 |
| 1975-07-01 | vs HOU | 78 | W 8-7 | 50-28 | 1 | 22,707 | Fred Norman | J.R. Richard | Pat Darcy | Joe Niekro | | 398 | 276 | 122 |
| 1975-07-02 | vs HOU | 79 | W 4-3 | 51-28 | 1 | 23,080 | Tom Carroll | Larry Dierker | Rawly Eastwick | Larry Dierker | | 402 | 279 | 123 |
| 1975-07-03 | @ SDN | 80 | L 1-2 | 51-29 | 1 | 15,145 | Gary Nolan | Randy Jones | Randy Jones | Will McEnaney | | 403 | 281 | 122 |
| 1975-07-04 | @ SDN | 81 | W 7-6 | 52-29 | 1 | 47,076 | Jack Billingham | Rich Folkers | Jack Billingham | Rich Folkers | Will McEnaney | 410 | 287 | 123 |
| 1975-07-05 | @ SDN | 82 | W 6-3 | 53-29 | 1 | 49,618 | Fred Norman | Brent Strom | Fred Norman | Brent Strom | Rawly Eastwick | 416 | 290 | 126 |
| 1975-07-06 | @ SDN | 83 | W 13-2 | 54-29 | 1 | 16,932 | Clay Kirby | Joe McIntosh | Clay Kirby | Joe McIntosh | Pedro Borbon | 429 | 292 | 137 |
| 1975-07-07 | vs PHI | 84 | W 7-3 | 55-29 | 1 | 25,096 | Pat Darcy | Steve Carlton | Pat Darcy | Steve Carlton | | 436 | 295 | 141 |
| 1975-07-08 | vs PHI | 85 | W 2-1 | 56-29 | 1 | 28,479 | Gary Nolan | Tom Underwood | Gary Nolan | Tom Underwood | Rawly Eastwick | 438 | 296 | 142 |
| 1975-07-09 | vs PHI | 86 | W 9-7 | 57-29 | 1 | 28,789 | Jack Billingham | Jim Lonborg | Pedro Borbon | Gene Garber | | 447 | 303 | 144 |
| 1975-07-11 | vs NYN | 87 | W 4-3 | 59-29 | 1 | 0 | Fred Norman | Jon Matlack | Fred Norman | Jon Matlack | Will McEnaney | 451 | 306 | 145 |
| 1975-07-11 | vs NYN | 88 | W 4-1 | 59-29 | 1 | 48,213 | Clay Kirby | Randy Tate | Clay Kirby | Randy Tate | Will McEnaney | 455 | 307 | 148 |
| 1975-07-12 | vs NYN | 89 | W 3-2 | 60-29 | 1 | 47,183 | Pat Darcy | Jerry Koosman | Tom Carroll | Jerry Koosman | Rawly Eastwick | 458 | 309 | 149 |
| 1975-07-13 | vs NYN | 90 | W 5-3 | 61-29 | 1 | 42,180 | Gary Nolan | Tom Seaver | Will McEnaney | Tom Seaver | Rawly Eastwick | 463 | 312 | 151 |
| 1975-07-17 | @ MON | 91 | L 0-3 | 61-30 | 1 | 20,024 | Jack Billingham | Steve Rogers | Steve Rogers | Jack Billingham | Dale Murray | 463 | 315 | 148 |
| 1975-07-18 | @ MON | 92 | W 10-3 | 62-30 | 1 | 17,158 | Gary Nolan | Dennis Blair | Gary Nolan | Dennis Blair | Rawly Eastwick | 473 | 318 | 155 |
| 1975-07-19 | @ MON | 93 | L 2-4 | 62-31 | 1 | 15,188 | Fred Norman | Steve Renko | Dale Murray | Pedro Borbon | | 475 | 322 | 153 |
| 1975-07-20 | @ PHI | 94 | L 4-11 | 62-32 | 1 | 44,134 | Clay Kirby | Tom Underwood | Tom Underwood | Clay Kirby | Gene Garber | 479 | 333 | 146 |
| 1975-07-21 | @ PHI | 95 | W 10-4 | 63-32 | 1 | 43,698 | Pat Darcy | Ron Schueler | Pat Darcy | Ron Schueler | | 489 | 337 | 152 |
| 1975-07-22 | @ NYN | 96 | L 1-3 | 63-33 | 1 | 32,759 | Jack Billingham | Jerry Koosman | Jerry Koosman | Jack Billingham | | 490 | 340 | 150 |
| 1975-07-23 | @ NYN | 97 | L 2-5 | 63-34 | 1 | 34,649 | Gary Nolan | Jon Matlack | Jon Matlack | Gary Nolan | | 492 | 345 | 147 |
| 1975-07-24 | @ NYN | 98 | W 2-1 | 64-34 | 1 | 41,423 | Fred Norman | Tom Seaver | Fred Norman | Tom Seaver | Rawly Eastwick | 494 | 346 | 148 |
| 1975-07-25 | vs LAN | 99 | L 3-4 | 65-35 | 1 | 0 | Clay Kirby | Andy Messersmith | Andy Messersmith | Clay Carroll | Mike Marshall | 497 | 350 | 147 |
| 1975-07-25 | vs LAN | 100 | W 6-3 | 65-35 | 1 | 51,087 | Pat Darcy | Al Downing | Pat Darcy | Mike Marshall | Pedro Borbon | 503 | 353 | 150 |
| 1975-07-26 | vs LAN | 101 | W 5-3 | 66-35 | 1 | 50,236 | Jack Billingham | Doug Rau | Jack Billingham | Doug Rau | Rawly Eastwick | 508 | 356 | 152 |
| 1975-07-27 | vs LAN | 102 | L 3-5 | 66-36 | 1 | 50,609 | Tom Carroll | Don Sutton | Don Sutton | Tom Carroll | Mike Marshall | 511 | 361 | 150 |
| 1975-07-28 | vs SFN | 103 | W 8-4 | 67-36 | 1 | 28,044 | Gary Nolan | Ed Halicki | Pedro Borbon | Ed Halicki | | 519 | 365 | 154 |
| 1975-07-29 | vs SFN | 104 | L 2-4 | 67-37 | 1 | 28,637 | Fred Norman | Jim Barr | Jim Barr | Rawly Eastwick | | 521 | 369 | 152 |
| 1975-07-30 | vs SFN | 105 | W 6-1 | 68-37 | 1 | 28,658 | Pat Darcy | Pete Falcone | Pat Darcy | Pete Falcone | | 527 | 370 | 157 |
| 1975-07-31 | vs SFN | 106 | W 11-6 | 69-37 | 1 | 31,620 | Clay Kirby | John Montefusco | Clay Kirby | John Montefusco | Clay Carroll | 538 | 376 | 162 |
| 1975-08-01 | @ LAN | 107 | L 3-5 | 69-38 | 1 | 50,331 | Jack Billingham | Don Sutton | Charlie Hough | Pedro Borbon | | 541 | 381 | 160 |
| 1975-08-02 | @ LAN | 108 | W 1-0 | 70-38 | 1 | 52,015 | Tom Carroll | Andy Messersmith | Tom Carroll | Andy Messersmith | Clay Carroll | 542 | 381 | 161 |
| 1975-08-03 | @ LAN | 109 | W 3-1 | 71-38 | 1 | 51,667 | Pat Darcy | Doug Rau | Pat Darcy | Doug Rau | Rawly Eastwick | 545 | 382 | 163 |
| 1975-08-04 | @ SFN | 110 | W 7-5 | 72-38 | 1 | 13,561 | Fred Norman | John Montefusco | Clay Carroll | Mike Caldwell | Rawly Eastwick | 552 | 387 | 165 |
| 1975-08-05 | @ SFN | 111 | W 6-3 | 73-38 | 1 | 8,812 | Clay Kirby | Ed Halicki | Pedro Borbon | Ed Halicki | Will McEnaney | 558 | 390 | 168 |
| 1975-08-06 | @ SFN | 112 | W 12-5 | 74-38 | 1 | 14,389 | Jack Billingham | Jim Barr | Jack Billingham | Jim Barr | | 570 | 395 | 175 |
| 1975-08-08 | vs MON | 113 | L 7-8 | 74-39 | 1 | 44,030 | Tom Carroll | Dan Warthen | Woodie Fryman | Pedro Borbon | | 577 | 403 | 174 |
| 1975-08-09 | vs MON | 114 | W 9-1 | 75-39 | 1 | 40,295 | Gary Nolan | Dennis Blair | Gary Nolan | Dennis Blair | Clay Carroll | 586 | 404 | 182 |
| 1975-08-10 | vs MON | 115 | W 11-3 | 76-39 | 1 | 30,660 | Fred Norman | Don Carrithers | Fred Norman | Don Carrithers | Rawly Eastwick | 597 | 407 | 190 |
| 1975-08-11 | vs CHN | 116 | W 9-3 | 77-39 | 1 | 27,725 | Jack Billingham | Rick Reuschel | Jack Billingham | Rick Reuschel | | 606 | 410 | 196 |
| 1975-08-12 | vs CHN | 117 | W 12-8 | 78-39 | 1 | 31,550 | Pat Darcy | Tom Dettore | Rawly Eastwick | Darold Knowles | | 618 | 418 | 200 |
| 1975-08-14 | vs PIT | 118 | W 6-1 | 79-39 | 1 | 40,062 | Gary Nolan | Jerry Reuss | Gary Nolan | Jerry Reuss | | 624 | 419 | 205 |
| 1975-08-15 | vs PIT | 119 | W 8-3 | 80-39 | 1 | 45,003 | Fred Norman | Jim Rooker | Fred Norman | Jim Rooker | | 632 | 422 | 210 |
| 1975-08-16 | vs PIT | 120 | W 5-3 | 81-39 | 1 | 51,286 | Jack Billingham | John Candelaria | Jack Billingham | John Candelaria | Rawly Eastwick | 637 | 425 | 212 |
| 1975-08-17 | vs PIT | 121 | W 3-1 | 82-39 | 1 | 50,121 | Pat Darcy | Bruce Kison | Pat Darcy | Bruce Kison | Rawly Eastwick | 640 | 426 | 214 |
| 1975-08-18 | @ SLN | 122 | W 3-2 | 83-39 | 1 | 35,937 | Don Gullett | Bob Forsch | Don Gullett | Bob Forsch | Rawly Eastwick | 643 | 428 | 215 |
| 1975-08-19 | @ SLN | 123 | L 1-2 | 83-40 | 1 | 34,977 | Gary Nolan | Lynn McGlothen | Lynn McGlothen | Gary Nolan | | 644 | 430 | 214 |
| 1975-08-20 | @ SLN | 124 | L 0-4 | 83-41 | 1 | 37,164 | Fred Norman | Ron Reed | Ron Reed | Fred Norman | | 644 | 434 | 210 |
| 1975-08-22 | @ PIT | 125 | L 2-7 | 83-43 | 1 | 0 | Jack Billingham | Larry Demery | Larry Demery | Jack Billingham | | 646 | 441 | 205 |
| 1975-08-22 | @ PIT | 126 | L 2-4 | 83-43 | 1 | 46,576 | Pat Darcy | John Candelaria | John Candelaria | Will McEnaney | Dave Giusti | 648 | 445 | 203 |
| 1975-08-23 | @ PIT | 127 | W 12-7 | 84-43 | 1 | 32,068 | Don Gullett | Bruce Kison | Clay Kirby | Bruce Kison | Rawly Eastwick | 660 | 452 | 208 |
| 1975-08-24 | @ PIT | 128 | L 1-5 | 84-44 | 1 | 35,598 | Gary Nolan | Jerry Reuss | Jerry Reuss | Gary Nolan | | 661 | 457 | 204 |
| 1975-08-25 | @ CHN | 129 | W 11-4 | 85-44 | 1 | 12,267 | Fred Norman | Rick Reuschel | Fred Norman | Rick Reuschel | Clay Carroll | 672 | 461 | 211 |
| 1975-08-26 | @ CHN | 130 | W 6-5 | 86-44 | 1 | 19,045 | Jack Billingham | Steve Stone | Rawly Eastwick | Steve Stone | Will McEnaney | 678 | 466 | 212 |
| 1975-08-27 | @ CHN | 131 | W 6-5 | 87-44 | 1 | 17,744 | Pat Darcy | Bill Bonham | Pedro Borbon | Bill Bonham | Rawly Eastwick | 684 | 471 | 213 |
| 1975-08-28 | vs SLN | 132 | W 4-0 | 88-44 | 1 | 30,345 | Don Gullett | Bob Forsch | Don Gullett | Mike Garman | | 688 | 471 | 217 |
| 1975-08-29 | vs SLN | 133 | W 6-2 | 89-44 | 1 | 33,290 | Gary Nolan | Lynn McGlothen | Gary Nolan | Lynn McGlothen | Will McEnaney | 694 | 473 | 221 |
| 1975-08-30 | vs SLN | 134 | W 3-2 | 90-44 | 1 | 45,064 | Fred Norman | Ron Reed | Rawly Eastwick | Mike Garman | | 697 | 475 | 222 |
| 1975-08-31 | vs SLN | 135 | L 3-5 | 90-45 | 1 | 43,470 | Jack Billingham | Eric Rasmussen | Eric Rasmussen | Jack Billingham | John Curtis | 700 | 480 | 220 |
| 1975-09-01 | vs SDN | 136 | L 1-2 | 90-46 | 1 | 17,022 | Pat Darcy | Randy Jones | Randy Jones | Pedro Borbon | | 701 | 482 | 219 |
| 1975-09-02 | vs SDN | 137 | W 10-4 | 91-46 | 1 | 14,240 | Don Gullett | Dan Spillner | Don Gullett | Dan Spillner | | 711 | 486 | 225 |
| 1975-09-03 | vs LAN | 138 | W 13-2 | 92-46 | 1 | 27,881 | Gary Nolan | Andy Messersmith | Gary Nolan | Andy Messersmith | | 724 | 488 | 236 |
| 1975-09-04 | vs LAN | 139 | L 2-3 | 92-47 | 1 | 29,512 | Clay Kirby | Doug Rau | Doug Rau | Clay Kirby | | 726 | 491 | 235 |
| 1975-09-05 | vs SFN | 140 | W 4-3 | 93-47 | 1 | 24,022 | Fred Norman | Jim Barr | Rawly Eastwick | Dave Heaverlo | | 730 | 494 | 236 |
| 1975-09-06 | vs SFN | 141 | W 3-2 | 94-47 | 1 | 37,015 | Jack Billingham | Ed Halicki | Jack Billingham | Ed Halicki | Will McEnaney | 733 | 496 | 237 |
| 1975-09-07 | vs SFN | 142 | W 8-4 | 95-47 | 1 | 34,415 | Don Gullett | Pete Falcone | Don Gullett | Pete Falcone | | 741 | 500 | 241 |
| 1975-09-08 | @ SDN | 143 | W 3-2 | 96-47 | 1 | 27,267 | Gary Nolan | Joe McIntosh | Clay Carroll | Bill Greif | Rawly Eastwick | 744 | 502 | 242 |
| 1975-09-09 | @ SDN | 144 | L 2-11 | 96-48 | 1 | 12,444 | Clay Kirby | Rich Folkers | Rich Folkers | Clay Kirby | | 746 | 513 | 233 |
| 1975-09-10 | @ LAN | 145 | L 2-3 | 96-49 | 1 | 27,432 | Pat Darcy | Burt Hooton | Burt Hooton | Rawly Eastwick | | 748 | 516 | 232 |
| 1975-09-11 | @ LAN | 146 | L 2-5 | 96-50 | 1 | 27,640 | Jack Billingham | Rick Rhoden | Rick Rhoden | Jack Billingham | | 750 | 521 | 229 |
| 1975-09-12 | @ SFN | 147 | W 6-3 | 97-50 | 1 | 5,614 | Fred Norman | John Montefusco | Fred Norman | John Montefusco | Rawly Eastwick | 756 | 524 | 232 |
| 1975-09-13 | @ SFN | 148 | L 2-9 | 97-51 | 1 | 5,453 | Don Gullett | Jim Barr | Jim Barr | Don Gullett | | 758 | 533 | 225 |
| 1975-09-14 | @ SFN | 149 | L 2-4 | 98-52 | 1 | 0 | Gary Nolan | Rob Dressler | Dave Heaverlo | Gary Nolan | | 760 | 537 | 223 |
| 1975-09-14 | @ SFN | 150 | W 8-3 | 98-52 | 1 | 16,997 | Pat Darcy | Greg Minton | Pat Darcy | Greg Minton | | 768 | 540 | 228 |
| 1975-09-16 | vs HOU | 151 | L 1-5 | 98-53 | 1 | 16,025 | Jack Billingham | Larry Dierker | Larry Dierker | Jack Billingham | | 769 | 545 | 224 |
| 1975-09-17 | vs HOU | 152 | W 10-1 | 99-53 | 1 | 13,508 | Fred Norman | Mike Stanton | Fred Norman | Mike Stanton | | 779 | 546 | 233 |
| 1975-09-18 | @ ATL | 153 | W 4-3 | 100-53 | 1 | 3,123 | Clay Kirby | Carl Morton | Pedro Borbon | Pablo Torrealba | | 783 | 549 | 234 |
| 1975-09-19 | @ ATL | 154 | W 7-6 | 101-53 | 1 | 4,290 | Pat Darcy | Frank LaCorte | Pat Darcy | Frank LaCorte | Will McEnaney | 790 | 555 | 235 |
| 1975-09-20 | @ ATL | 155 | W 9-2 | 102-53 | 1 | 7,094 | Gary Nolan | Jamie Easterly | Gary Nolan | Jamie Easterly | | 799 | 557 | 242 |
| 1975-09-21 | @ ATL | 156 | W 3-0 | 103-53 | 1 | 6,858 | Don Gullett | Phil Niekro | Don Gullett | Phil Niekro | Rawly Eastwick | 802 | 557 | 245 |
| 1975-09-22 | @ HOU | 157 | L 1-5 | 103-54 | 1 | 6,422 | Jack Billingham | Joe Niekro | Joe Niekro | Jack Billingham | Paul Siebert | 803 | 562 | 241 |
| 1975-09-23 | @ HOU | 158 | W 5-3 | 104-54 | 1 | 7,712 | Fred Norman | Mike Cosgrove | Fred Norman | Mike Cosgrove | Rawly Eastwick | 808 | 565 | 243 |
| 1975-09-24 | @ HOU | 159 | W 6-4 | 105-54 | 1 | 10,237 | Clay Kirby | Larry Dierker | Clay Kirby | Larry Dierker | Rawly Eastwick | 814 | 569 | 245 |
| 1975-09-26 | vs ATL | 160 | W 12-5 | 106-54 | 1 | 18,720 | Gary Nolan | Phil Niekro | Gary Nolan | Phil Niekro | Pedro Borbon | 826 | 574 | 252 |
| 1975-09-27 | vs ATL | 161 | W 7-6 | 107-54 | 1 | 27,105 | Don Gullett | Blue Moon Odom | Don Gullett | Blue Moon Odom | Pat Darcy | 833 | 580 | 253 |
| 1975-09-28 | vs ATL | 162 | W 7-6 | 108-54 | 1 | 44,130 | Fred Norman | Carl Morton | Will McEnaney | Bruce Dal Canton | | 840 | 586 | 254 |