| 1975-04-08 | @ OAK | 1 | L 2-3 | 0-1 | 4 | 17,477 | Wilbur Wood | Vida Blue | Vida Blue | Wilbur Wood | Rollie Fingers | 2 | 3 | -1 |
| 1975-04-09 | @ OAK | 2 | W 7-5 | 1-1 | 2 | 4,543 | Jim Kaat | Ken Holtzman | Jim Kaat | Rollie Fingers | | 9 | 8 | 1 |
| 1975-04-10 | @ OAK | 3 | L 0-9 | 1-2 | 5 | 4,730 | Stan Bahnsen | Mike Norris | Mike Norris | Stan Bahnsen | | 9 | 17 | -8 |
| 1975-04-11 | @ CAL | 4 | L 0-5 | 1-3 | 5 | 20,028 | Claude Osteen | Nolan Ryan | Nolan Ryan | Claude Osteen | | 9 | 22 | -13 |
| 1975-04-12 | @ CAL | 5 | L 3-4 | 1-4 | 5 | 6,517 | Wilbur Wood | Andy Hassler | Andy Hassler | Wilbur Wood | | 12 | 26 | -14 |
| 1975-04-13 | @ CAL | 6 | W 7-5 | 3-4 | 4 | 0 | Jim Kaat | Chuck Dobson | Terry Forster | Don Kirkwood | Rich Gossage | 19 | 31 | -12 |
| 1975-04-13 | @ CAL | 7 | W 5-4 | 3-4 | 4 | 14,626 | Stan Bahnsen | Bill Singer | Cecil Upshaw | Bill Singer | Rich Gossage | 24 | 35 | -11 |
| 1975-04-15 | vs TEX | 8 | L 5-6 | 3-5 | 4 | 20,202 | Claude Osteen | Clyde Wright | Steve Hargan | Rich Gossage | | 29 | 41 | -12 |
| 1975-04-16 | vs TEX | 9 | L 4-14 | 3-6 | 6 | 2,159 | Wilbur Wood | Jim Bibby | Jim Umbarger | Wilbur Wood | | 33 | 55 | -22 |
| 1975-04-17 | vs TEX | 10 | L 3-7 | 3-7 | 6 | 1,295 | Stan Bahnsen | Fergie Jenkins | Fergie Jenkins | Stan Bahnsen | | 36 | 62 | -26 |
| 1975-04-19 | vs CAL | 11 | L 5-6 | 3-8 | 6 | 4,591 | Wilbur Wood | Bill Singer | Bill Singer | Wilbur Wood | Don Kirkwood | 41 | 68 | -27 |
| 1975-04-20 | vs CAL | 12 | L 4-8 | 3-9 | 6 | 4,801 | Claude Osteen | Nolan Ryan | Nolan Ryan | Claude Osteen | | 45 | 76 | -31 |
| 1975-04-22 | vs KCA | 13 | W 7-3 | 4-9 | 6 | 4,859 | Jim Kaat | Bruce Dal Canton | Jim Kaat | Bruce Dal Canton | Terry Forster | 52 | 79 | -27 |
| 1975-04-24 | @ MIN | 14 | W 4-3 | 5-9 | 6 | 2,516 | Wilbur Wood | Bert Blyleven | Wilbur Wood | Tom Burgmeier | Terry Forster | 56 | 82 | -26 |
| 1975-04-25 | @ KCA | 15 | W 5-2 | 6-9 | 4 | 10,903 | Claude Osteen | Al Fitzmorris | Claude Osteen | Al Fitzmorris | Rich Gossage | 61 | 84 | -23 |
| 1975-04-26 | @ KCA | 16 | L 6-8 | 6-10 | 5 | 8,749 | Stan Bahnsen | Nelson Briles | Nelson Briles | Stan Bahnsen | Doug Bird | 67 | 92 | -25 |
| 1975-04-27 | @ KCA | 17 | W 8-6 | 7-10 | 5 | 9,803 | Jim Kaat | Bruce Dal Canton | Jim Kaat | Bruce Dal Canton | Rich Gossage | 75 | 98 | -23 |
| 1975-04-28 | @ KCA | 18 | L 5-7 | 7-11 | 5 | 8,352 | Wilbur Wood | Steve Busby | Steve Busby | Wilbur Wood | | 80 | 105 | -25 |
| 1975-04-29 | @ TEX | 19 | L 2-3 | 7-12 | 6 | 7,107 | Claude Osteen | Fergie Jenkins | Fergie Jenkins | Claude Osteen | | 82 | 108 | -26 |
| 1975-04-30 | @ TEX | 20 | L 2-8 | 7-13 | 6 | 8,105 | Stan Bahnsen | Jim Bibby | Jim Bibby | Stan Bahnsen | | 84 | 116 | -32 |
| 1975-05-01 | @ TEX | 21 | L 1-2 | 7-14 | 6 | 6,481 | Jim Kaat | Clyde Wright | Steve Foucault | Rich Gossage | | 85 | 118 | -33 |
| 1975-05-02 | vs OAK | 22 | L 3-4 | 7-15 | 6 | 12,113 | Wilbur Wood | Vida Blue | Rollie Fingers | Terry Forster | Paul Lindblad | 88 | 122 | -34 |
| 1975-05-03 | vs OAK | 23 | W 4-3 | 8-15 | 6 | 17,874 | Claude Osteen | Ken Holtzman | Rich Gossage | Jim Todd | | 92 | 125 | -33 |
| 1975-05-04 | vs OAK | 24 | W 5-2 | 9-15 | 6 | 12,931 | Jim Kaat | Glenn Abbott | Jim Kaat | Glenn Abbott | Terry Forster | 97 | 127 | -30 |
| 1975-05-06 | vs MIN | 25 | L 1-4 | 9-16 | 6 | 3,458 | Wilbur Wood | Dave Goltz | Dave Goltz | Wilbur Wood | Bill Campbell | 98 | 131 | -33 |
| 1975-05-07 | vs MIN | 26 | W 3-2 | 10-16 | 6 | 3,255 | Claude Osteen | Bert Blyleven | Terry Forster | Bill Campbell | | 101 | 133 | -32 |
| 1975-05-09 | @ CLE | 27 | W 2-0 | 11-16 | 6 | 10,422 | Jim Kaat | Gaylord Perry | Jim Kaat | Gaylord Perry | Terry Forster | 103 | 133 | -30 |
| 1975-05-10 | @ CLE | 28 | W 8-3 | 12-16 | 6 | 10,165 | Wilbur Wood | Don Hood | Wilbur Wood | Don Hood | Rich Gossage | 111 | 136 | -25 |
| 1975-05-11 | @ CLE | 29 | L 3-4 | 12-17 | 6 | 19,490 | Claude Osteen | Jim Kern | Tom Buskey | Terry Forster | | 114 | 140 | -26 |
| 1975-05-13 | @ BAL | 30 | L 2-3 | 12-18 | 6 | 4,574 | Jim Kaat | Ross Grimsley | Ross Grimsley | Jim Kaat | | 116 | 143 | -27 |
| 1975-05-14 | @ BAL | 31 | L 2-3 | 12-19 | 6 | 6,828 | Wilbur Wood | Mike Torrez | Mike Torrez | Terry Forster | | 118 | 146 | -28 |
| 1975-05-16 | vs CLE | 32 | W 3-2 | 13-19 | 6 | 5,794 | Claude Osteen | Jim Kern | Rich Gossage | Tom Buskey | | 121 | 148 | -27 |
| 1975-05-17 | vs CLE | 33 | W 10-1 | 14-19 | 6 | 8,070 | Jim Kaat | Fritz Peterson | Jim Kaat | Fritz Peterson | | 131 | 149 | -18 |
| 1975-05-18 | vs CLE | 34 | L 6-7 | 14-20 | 6 | 10,033 | Wilbur Wood | Gaylord Perry | Gaylord Perry | Wilbur Wood | Dennis Eckersley | 137 | 156 | -19 |
| 1975-05-19 | vs BAL | 35 | W 2-1 | 15-20 | 6 | 6,308 | Stan Bahnsen | Doyle Alexander | Stan Bahnsen | Doyle Alexander | Rich Gossage | 139 | 157 | -18 |
| 1975-05-21 | vs BAL | 36 | L 2-6 | 15-21 | 6 | 4,250 | Claude Osteen | Jim Palmer | Jim Palmer | Claude Osteen | | 141 | 163 | -22 |
| 1975-05-22 | vs BAL | 37 | W 2-1 | 16-21 | 6 | 2,467 | Jim Kaat | Mike Cuellar | Jim Kaat | Mike Cuellar | Rich Gossage | 143 | 164 | -21 |
| 1975-05-23 | vs DET | 38 | W 6-1 | 17-21 | 6 | 8,789 | Wilbur Wood | Lerrin LaGrow | Terry Forster | Lerrin LaGrow | | 149 | 165 | -16 |
| 1975-05-24 | vs DET | 39 | W 10-8 | 18-21 | 6 | 29,683 | Stan Bahnsen | Joe Coleman | Stan Bahnsen | Joe Coleman | Bill Gogolewski | 159 | 173 | -14 |
| 1975-05-25 | vs DET | 40 | L 1-4 | 18-22 | 6 | 30,947 | Claude Osteen | Mickey Lolich | Mickey Lolich | Claude Osteen | | 160 | 177 | -17 |
| 1975-05-26 | @ MIL | 41 | W 4-2 | 19-22 | 6 | 16,343 | Jim Kaat | Jim Colborn | Jim Kaat | Jim Colborn | Rich Gossage | 164 | 179 | -15 |
| 1975-05-27 | @ MIL | 42 | L 8-9 | 19-23 | 6 | 12,066 | Wilbur Wood | Ed Sprague | Tom Hausman | Wilbur Wood | Tom Murphy | 172 | 188 | -16 |
| 1975-05-28 | @ MIL | 43 | W 9-3 | 20-23 | 6 | 9,971 | Stan Bahnsen | Jim Slaton | Stan Bahnsen | Jim Slaton | | 181 | 191 | -10 |
| 1975-05-31 | @ DET | 44 | L 0-2 | 20-24 | 6 | 13,152 | Jim Kaat | Vern Ruhle | Vern Ruhle | Jim Kaat | | 181 | 193 | -12 |
| 1975-06-01 | @ DET | 45 | L 1-5 | 21-25 | 6 | 0 | Wilbur Wood | Mickey Lolich | Mickey Lolich | Wilbur Wood | | 182 | 198 | -16 |
| 1975-06-01 | @ DET | 46 | W 3-2 | 21-25 | 6 | 26,749 | Claude Osteen | Lerrin LaGrow | Rich Gossage | Tom Walker | | 185 | 200 | -15 |
| 1975-06-02 | @ BOS | 47 | W 9-2 | 22-25 | 6 | 15,681 | Stan Bahnsen | Bill Lee | Stan Bahnsen | Bill Lee | | 194 | 202 | -8 |
| 1975-06-03 | @ BOS | 48 | L 0-4 | 22-26 | 6 | 10,625 | Lloyd Allen | Dick Pole | Dick Pole | Lloyd Allen | | 194 | 206 | -12 |
| 1975-06-04 | @ BOS | 49 | L 6-7 | 22-27 | 6 | 12,366 | Jim Kaat | Rick Wise | Roger Moret | Rich Gossage | | 200 | 213 | -13 |
| 1975-06-06 | vs NYA | 50 | L 1-5 | 22-28 | 6 | 17,159 | Wilbur Wood | Rudy May | Rudy May | Wilbur Wood | | 201 | 218 | -17 |
| 1975-06-07 | vs NYA | 51 | L 3-6 | 22-29 | 6 | 22,242 | Stan Bahnsen | Pat Dobson | Pat Dobson | Stan Bahnsen | | 204 | 224 | -20 |
| 1975-06-08 | vs NYA | 52 | L 1-4 | 22-30 | 6 | 13,423 | Jim Kaat | Doc Medich | Doc Medich | Jim Kaat | Sparky Lyle | 205 | 228 | -23 |
| 1975-06-09 | vs MIL | 53 | L 0-1 | 22-31 | 6 | 4,949 | Claude Osteen | Bill Travers | Eduardo Rodriguez | Rich Gossage | Tom Murphy | 205 | 229 | -24 |
| 1975-06-10 | vs MIL | 54 | W 9-2 | 23-31 | 6 | 5,541 | Wilbur Wood | Pete Broberg | Wilbur Wood | Pete Broberg | | 214 | 231 | -17 |
| 1975-06-11 | vs BOS | 55 | L 7-9 | 23-32 | 6 | 5,228 | Stan Bahnsen | Bill Lee | Roger Moret | Rich Gossage | Diego Segui | 221 | 240 | -19 |
| 1975-06-12 | vs BOS | 56 | W 9-2 | 24-32 | 6 | 5,944 | Jim Kaat | Jim Burton | Jim Kaat | Jim Burton | | 230 | 242 | -12 |
| 1975-06-13 | @ NYA | 57 | L 1-2 | 24-33 | 6 | 26,485 | Claude Osteen | Pat Dobson | Pat Dobson | Claude Osteen | | 231 | 244 | -13 |
| 1975-06-14 | @ NYA | 58 | W 7-2 | 25-33 | 6 | 31,120 | Wilbur Wood | Doc Medich | Wilbur Wood | Doc Medich | | 238 | 246 | -8 |
| 1975-06-15 | @ NYA | 59 | L 0-3 | 25-34 | 6 | 53,562 | Stan Bahnsen | Catfish Hunter | Catfish Hunter | Stan Bahnsen | | 238 | 249 | -11 |
| 1975-06-17 | @ TEX | 60 | W 13-3 | 26-34 | 6 | 11,973 | Jim Kaat | Jim Umbarger | Jim Kaat | Jim Umbarger | Rich Gossage | 251 | 252 | -1 |
| 1975-06-18 | @ TEX | 61 | L 3-10 | 26-35 | 6 | 11,076 | Wilbur Wood | Fergie Jenkins | Fergie Jenkins | Wilbur Wood | | 254 | 262 | -8 |
| 1975-06-19 | @ TEX | 62 | L 3-5 | 26-36 | 6 | 11,709 | Claude Osteen | Steve Hargan | Stan Thomas | Rich Gossage | | 257 | 267 | -10 |
| 1975-06-20 | vs MIN | 63 | L 3-5 | 26-37 | 6 | 9,208 | Dave Hamilton | Ray Corbin | Ray Corbin | Dave Hamilton | | 260 | 272 | -12 |
| 1975-06-21 | vs MIN | 64 | L 3-8 | 26-38 | 6 | 15,079 | Jim Kaat | Bill Campbell | Bill Campbell | Jim Kaat | | 263 | 280 | -17 |
| 1975-06-22 | vs MIN | 65 | W 6-5 | 28-38 | 6 | 0 | Wilbur Wood | Dave Goltz | Ozzie Osborn | Tom Burgmeier | | 269 | 285 | -16 |
| 1975-06-22 | vs MIN | 66 | W 9-2 | 28-38 | 6 | 23,299 | Jesse Jefferson | Vic Albury | Jesse Jefferson | Vic Albury | Cecil Upshaw | 278 | 287 | -9 |
| 1975-06-24 | vs TEX | 67 | W 7-5 | 29-38 | 6 | 6,318 | Claude Osteen | Gaylord Perry | Claude Osteen | Gaylord Perry | Rich Gossage | 285 | 292 | -7 |
| 1975-06-25 | vs TEX | 68 | W 5-2 | 30-38 | 6 | 6,590 | Jim Kaat | Mike Bacsik | Jim Kaat | Mike Bacsik | Dave Hamilton | 290 | 294 | -4 |
| 1975-06-26 | vs TEX | 69 | W 8-3 | 31-38 | 6 | 7,681 | Wilbur Wood | Fergie Jenkins | Wilbur Wood | Fergie Jenkins | Rich Gossage | 298 | 297 | 1 |
| 1975-06-27 | vs KCA | 70 | W 4-3 | 32-38 | 5 | 12,191 | Jesse Jefferson | Al Fitzmorris | Dave Hamilton | Doug Bird | | 302 | 300 | 2 |
| 1975-06-28 | vs KCA | 71 | W 5-3 | 33-38 | 5 | 14,361 | Claude Osteen | Dennis Leonard | Claude Osteen | Dennis Leonard | | 307 | 303 | 4 |
| 1975-06-29 | vs KCA | 72 | W 3-1 | 34-38 | 4 | 9,271 | Jim Kaat | Paul Splittorff | Jim Kaat | Paul Splittorff | Dave Hamilton | 310 | 304 | 6 |
| 1975-06-30 | vs OAK | 73 | W 6-1 | 35-38 | 4 | 21,536 | Wilbur Wood | Stan Bahnsen | Wilbur Wood | Stan Bahnsen | | 316 | 305 | 11 |
| 1975-07-01 | vs OAK | 74 | L 1-10 | 35-39 | 4 | 19,458 | Jesse Jefferson | Vida Blue | Vida Blue | Jesse Jefferson | | 317 | 315 | 2 |
| 1975-07-02 | vs OAK | 75 | W 5-4 | 36-39 | 4 | 16,750 | Claude Osteen | Jim Perry | Rich Gossage | Rollie Fingers | | 322 | 319 | 3 |
| 1975-07-03 | vs OAK | 76 | W 3-2 | 37-39 | 3 | 13,359 | Jim Kaat | Dick Bosman | Jim Kaat | Jim Todd | Rich Gossage | 325 | 321 | 4 |
| 1975-07-04 | @ KCA | 77 | L 2-3 | 37-40 | 3 | 29,118 | Wilbur Wood | Nelson Briles | Dennis Leonard | Wilbur Wood | | 327 | 324 | 3 |
| 1975-07-05 | @ KCA | 78 | L 4-6 | 37-41 | 3 | 20,211 | Jesse Jefferson | Steve Busby | Paul Splittorff | Dave Hamilton | | 331 | 330 | 1 |
| 1975-07-06 | @ KCA | 79 | W 9-3 | 38-41 | 4 | 10,633 | Claude Osteen | Marty Pattin | Claude Osteen | Marty Pattin | | 340 | 333 | 7 |
| 1975-07-07 | @ DET | 80 | L 1-2 | 38-42 | 4 | 15,377 | Jim Kaat | Tom Walker | Tom Walker | Jim Kaat | | 341 | 335 | 6 |
| 1975-07-08 | @ DET | 81 | L 0-3 | 38-43 | 4 | 13,268 | Wilbur Wood | Joe Coleman | Joe Coleman | Wilbur Wood | John Hiller | 341 | 338 | 3 |
| 1975-07-09 | @ DET | 82 | L 2-6 | 38-44 | 4 | 16,155 | Jesse Jefferson | Ray Bare | Ray Bare | Jesse Jefferson | | 343 | 344 | -1 |
| 1975-07-11 | @ MIL | 83 | W 5-3 | 39-44 | 3 | 19,655 | Claude Osteen | Ed Sprague | Claude Osteen | Ed Sprague | Rich Gossage | 348 | 347 | 1 |
| 1975-07-12 | @ MIL | 84 | L 4-5 | 39-45 | 3 | 28,079 | Jim Kaat | Jim Slaton | Jim Slaton | Jim Kaat | Eduardo Rodriguez | 352 | 352 | 0 |
| 1975-07-13 | @ MIL | 85 | W 5-0 | 40-45 | 3 | 27,386 | Wilbur Wood | Bill Travers | Wilbur Wood | Bill Travers | | 357 | 352 | 5 |
| 1975-07-17 | vs DET | 86 | W 4-0 | 41-46 | 3 | 0 | Wilbur Wood | Mickey Lolich | Wilbur Wood | Mickey Lolich | | 361 | 352 | 9 |
| 1975-07-17 | vs DET | 87 | L 1-9 | 41-46 | 3 | 13,161 | Claude Osteen | Lerrin LaGrow | Lerrin LaGrow | Claude Osteen | | 362 | 361 | 1 |
| 1975-07-18 | vs DET | 88 | W 4-0 | 42-46 | 3 | 11,701 | Jim Kaat | Vern Ruhle | Jim Kaat | Vern Ruhle | | 366 | 361 | 5 |
| 1975-07-19 | vs MIL | 89 | W 4-2 | 43-46 | 3 | 20,516 | Jesse Jefferson | Bill Travers | Jesse Jefferson | Bill Travers | Rich Gossage | 370 | 363 | 7 |
| 1975-07-20 | vs MIL | 90 | W 9-2 | 45-46 | 3 | 0 | Wilbur Wood | Ed Sprague | Wilbur Wood | Ed Sprague | | 379 | 365 | 14 |
| 1975-07-20 | vs MIL | 91 | W 10-5 | 45-46 | 3 | 24,719 | Claude Osteen | Pete Broberg | Ozzie Osborn | Pete Broberg | Bill Gogolewski | 389 | 370 | 19 |
| 1975-07-21 | vs MIL | 92 | L 4-7 | 45-47 | 3 | 11,550 | Claude Osteen | Jim Colborn | Jim Colborn | Claude Osteen | Rick Austin | 393 | 377 | 16 |
| 1975-07-22 | vs NYA | 93 | L 6-11 | 45-48 | 3 | 17,395 | Jim Kaat | Catfish Hunter | Catfish Hunter | Jim Kaat | Tippy Martinez | 399 | 388 | 11 |
| 1975-07-24 | vs NYA | 94 | W 4-3 | 47-48 | 3 | 0 | Wilbur Wood | Doc Medich | Rich Gossage | Dick Tidrow | | 403 | 391 | 12 |
| 1975-07-24 | vs NYA | 95 | W 1-0 | 47-48 | 3 | 13,910 | Jesse Jefferson | Larry Gura | Dave Hamilton | Larry Gura | | 404 | 391 | 13 |
| 1975-07-25 | @ OAK | 96 | L 6-8 | 47-49 | 3 | 10,500 | Claude Osteen | Ken Holtzman | Paul Lindblad | Cecil Upshaw | | 410 | 399 | 11 |
| 1975-07-26 | @ OAK | 97 | W 5-2 | 48-49 | 3 | 11,168 | Jim Kaat | Dick Bosman | Jim Kaat | Rollie Fingers | | 415 | 401 | 14 |
| 1975-07-27 | @ OAK | 98 | L 1-10 | 48-51 | 3 | 0 | Jesse Jefferson | Vida Blue | Vida Blue | Jesse Jefferson | | 416 | 411 | 5 |
| 1975-07-27 | @ OAK | 99 | L 1-7 | 48-51 | 3 | 21,254 | Lloyd Allen | Stan Bahnsen | Stan Bahnsen | Lloyd Allen | | 417 | 418 | -1 |
| 1975-07-28 | @ CAL | 100 | W 3-2 | 49-51 | 3 | 20,973 | Wilbur Wood | Frank Tanana | Wilbur Wood | Frank Tanana | Rich Gossage | 420 | 420 | 0 |
| 1975-07-29 | @ CAL | 101 | W 7-4 | 50-51 | 3 | 7,968 | Claude Osteen | Andy Hassler | Claude Osteen | Andy Hassler | Dave Hamilton | 427 | 424 | 3 |
| 1975-07-30 | @ CAL | 102 | L 4-5 | 50-52 | 3 | 11,095 | Jim Kaat | Nolan Ryan | Nolan Ryan | Jim Kaat | | 431 | 429 | 2 |
| 1975-08-01 | @ MIN | 103 | W 5-1 | 51-52 | 3 | 12,239 | Wilbur Wood | Dave Goltz | Wilbur Wood | Dave Goltz | | 436 | 430 | 6 |
| 1975-08-02 | @ MIN | 104 | L 1-4 | 51-54 | 3 | 0 | Claude Osteen | Bert Blyleven | Bert Blyleven | Claude Osteen | | 437 | 434 | 3 |
| 1975-08-02 | @ MIN | 105 | L 3-8 | 51-54 | 3 | 17,194 | Jesse Jefferson | Bill Butler | Bill Butler | Jesse Jefferson | | 440 | 442 | -2 |
| 1975-08-03 | @ MIN | 106 | L 4-7 | 51-56 | 3 | 0 | Jim Kaat | Vic Albury | Vic Albury | Jim Kaat | Mark Wiley | 444 | 449 | -5 |
| 1975-08-03 | @ MIN | 107 | L 9-12 | 51-56 | 3 | 14,782 | Pete Vuckovich | Bill Campbell | Bill Campbell | Pete Vuckovich | Mark Wiley | 453 | 461 | -8 |
| 1975-08-04 | vs CAL | 108 | W 4-2 | 52-56 | 3 | 5,400 | Wilbur Wood | Chuck Hockenbery | Wilbur Wood | Chuck Hockenbery | Rich Gossage | 457 | 463 | -6 |
| 1975-08-05 | vs CAL | 109 | L 4-10 | 53-57 | 3 | 0 | Claude Osteen | Ed Figueroa | Ed Figueroa | Claude Osteen | | 461 | 473 | -12 |
| 1975-08-05 | vs CAL | 110 | W 4-1 | 53-57 | 3 | 7,265 | Jesse Jefferson | Bill Singer | Jesse Jefferson | Bill Singer | Rich Gossage | 465 | 474 | -9 |
| 1975-08-06 | vs CAL | 111 | W 11-1 | 54-57 | 3 | 9,178 | Jim Kaat | Dick Lange | Jim Kaat | Dick Lange | | 476 | 475 | 1 |
| 1975-08-07 | vs CAL | 112 | W 8-4 | 55-57 | 3 | 10,543 | Pete Vuckovich | Andy Hassler | Dave Hamilton | Andy Hassler | | 484 | 479 | 5 |
| 1975-08-08 | vs BAL | 113 | L 4-7 | 55-58 | 3 | 12,199 | Wilbur Wood | Doyle Alexander | Doyle Alexander | Wilbur Wood | Dyar Miller | 488 | 486 | 2 |
| 1975-08-09 | vs BAL | 114 | L 6-12 | 55-59 | 3 | 15,343 | Claude Osteen | Jim Palmer | Jim Palmer | Claude Osteen | | 494 | 498 | -4 |
| 1975-08-10 | vs BAL | 115 | W 3-2 | 56-59 | 3 | 12,431 | Jim Kaat | Mike Torrez | Rich Gossage | Grant Jackson | | 497 | 500 | -3 |
| 1975-08-12 | vs CLE | 116 | L 3-6 | 56-60 | 4 | 8,327 | Wilbur Wood | Fritz Peterson | Fritz Peterson | Wilbur Wood | Dave LaRoche | 500 | 506 | -6 |
| 1975-08-13 | vs CLE | 117 | W 4-3 | 57-60 | 4 | 5,551 | Claude Osteen | Don Hood | Rich Gossage | Jim Bibby | | 504 | 509 | -5 |
| 1975-08-14 | vs CLE | 118 | W 6-4 | 58-60 | 3 | 7,399 | Jim Kaat | Roric Harrison | Jim Kaat | Roric Harrison | Dave Hamilton | 510 | 513 | -3 |
| 1975-08-15 | vs BOS | 119 | L 2-3 | 58-61 | 4 | 17,281 | Jesse Jefferson | Luis Tiant | Luis Tiant | Jesse Jefferson | | 512 | 516 | -4 |
| 1975-08-16 | vs BOS | 120 | L 0-5 | 58-62 | 4 | 15,352 | Wilbur Wood | Roger Moret | Roger Moret | Wilbur Wood | Jim Willoughby | 512 | 521 | -9 |
| 1975-08-17 | vs BOS | 121 | W 6-2 | 59-63 | 4 | 0 | Terry Forster | Rick Wise | Dave Hamilton | Rick Wise | Rich Gossage | 518 | 523 | -5 |
| 1975-08-17 | vs BOS | 122 | L 3-4 | 59-63 | 4 | 21,995 | Jim Kaat | Reggie Cleveland | Jim Willoughby | Rich Gossage | | 521 | 527 | -6 |
| 1975-08-19 | @ NYA | 123 | W 7-6 | 60-63 | 3 | 12,738 | Jesse Jefferson | Larry Gura | Dave Hamilton | Sparky Lyle | | 528 | 533 | -5 |
| 1975-08-20 | @ NYA | 124 | W 5-3 | 61-63 | 3 | 12,304 | Wilbur Wood | Rudy May | Wilbur Wood | Rudy May | | 533 | 536 | -3 |
| 1975-08-21 | @ NYA | 125 | W 2-1 | 62-63 | 3 | 10,012 | Jim Kaat | Doc Medich | Jim Kaat | Doc Medich | Rich Gossage | 535 | 537 | -2 |
| 1975-08-22 | @ BOS | 126 | L 1-2 | 62-64 | 3 | 32,458 | Claude Osteen | Roger Moret | Roger Moret | Claude Osteen | | 536 | 539 | -3 |
| 1975-08-23 | @ BOS | 127 | W 6-4 | 63-64 | 3 | 27,730 | Jesse Jefferson | Rick Wise | Jesse Jefferson | Rick Wise | Rich Gossage | 542 | 543 | -1 |
| 1975-08-24 | @ BOS | 128 | L 1-6 | 63-65 | 3 | 22,024 | Wilbur Wood | Bill Lee | Bill Lee | Wilbur Wood | | 543 | 549 | -6 |
| 1975-08-25 | @ CLE | 129 | L 1-5 | 63-66 | 4 | 8,171 | Jim Kaat | Dennis Eckersley | Dennis Eckersley | Jim Kaat | | 544 | 554 | -10 |
| 1975-08-27 | @ CLE | 130 | W 2-0 | 64-67 | 4 | 0 | Claude Osteen | Jim Bibby | Claude Osteen | Jim Bibby | Rich Gossage | 546 | 554 | -8 |
| 1975-08-27 | @ CLE | 131 | L 0-5 | 64-67 | 4 | 9,297 | Jesse Jefferson | Fritz Peterson | Fritz Peterson | Jesse Jefferson | | 546 | 559 | -13 |
| 1975-08-28 | @ BAL | 132 | L 1-2 | 64-68 | 4 | 10,459 | Wilbur Wood | Mike Cuellar | Mike Cuellar | Wilbur Wood | | 547 | 561 | -14 |
| 1975-08-29 | @ BAL | 133 | W 4-2 | 65-68 | 4 | 10,307 | Jim Kaat | Ross Grimsley | Jim Kaat | Ross Grimsley | Rich Gossage | 551 | 563 | -12 |
| 1975-08-30 | @ BAL | 134 | L 2-4 | 65-69 | 4 | 12,498 | Jesse Jefferson | Jim Palmer | Jim Palmer | Jesse Jefferson | | 553 | 567 | -14 |
| 1975-09-01 | vs KCA | 135 | W 10-8 | 66-70 | 4 | 0 | Wilbur Wood | Steve Busby | Rich Gossage | Steve Busby | | 563 | 575 | -12 |
| 1975-09-01 | vs KCA | 136 | L 1-3 | 66-70 | 4 | 9,605 | Claude Osteen | Nelson Briles | Doug Bird | Claude Osteen | | 564 | 578 | -14 |
| 1975-09-02 | vs KCA | 137 | L 1-4 | 66-71 | 4 | 4,198 | Jim Kaat | Al Fitzmorris | Al Fitzmorris | Jim Kaat | Marty Pattin | 565 | 582 | -17 |
| 1975-09-03 | vs KCA | 138 | L 4-5 | 66-72 | 5 | 3,900 | Jesse Jefferson | Dennis Leonard | Dennis Leonard | Dave Hamilton | Marty Pattin | 569 | 587 | -18 |
| 1975-09-04 | vs KCA | 139 | L 0-7 | 66-73 | 5 | 1,569 | Ken Kravec | Paul Splittorff | Paul Splittorff | Ken Kravec | | 569 | 594 | -25 |
| 1975-09-05 | vs MIN | 140 | W 3-2 | 67-73 | 4 | 4,400 | Wilbur Wood | Dave Goltz | Wilbur Wood | Dave Goltz | Rich Gossage | 572 | 596 | -24 |
| 1975-09-06 | vs MIN | 141 | W 5-2 | 68-73 | 4 | 7,078 | Jim Kaat | Bert Blyleven | Jim Kaat | Bert Blyleven | Rich Gossage | 577 | 598 | -21 |
| 1975-09-07 | vs MIN | 142 | L 1-9 | 68-74 | 4 | 6,008 | Claude Osteen | Jim Hughes | Jim Hughes | Claude Osteen | | 578 | 607 | -29 |
| 1975-09-09 | vs CAL | 143 | L 4-5 | 68-75 | 4 | 2,958 | Wilbur Wood | Ed Figueroa | Ed Figueroa | Wilbur Wood | Jim Brewer | 582 | 612 | -30 |
| 1975-09-10 | vs CAL | 144 | L 2-4 | 68-76 | 4 | 3,233 | Jim Kaat | Frank Tanana | Frank Tanana | Jim Kaat | | 584 | 616 | -32 |
| 1975-09-12 | @ TEX | 145 | W 5-2 | 69-76 | 4 | 6,007 | Jesse Jefferson | Fergie Jenkins | Rich Hinton | Fergie Jenkins | Rich Gossage | 589 | 618 | -29 |
| 1975-09-13 | @ TEX | 146 | L 7-8 | 69-77 | 4 | 11,102 | Wilbur Wood | Jim Umbarger | Steve Foucault | Dave Hamilton | | 596 | 626 | -30 |
| 1975-09-14 | @ TEX | 147 | L 8-9 | 69-78 | 4 | 6,705 | Jim Kaat | Jim Gideon | Steve Foucault | Dave Hamilton | | 604 | 635 | -31 |
| 1975-09-15 | @ KCA | 148 | L 2-3 | 69-79 | 5 | 6,398 | Claude Osteen | Paul Splittorff | Paul Splittorff | Claude Osteen | | 606 | 638 | -32 |
| 1975-09-16 | @ KCA | 149 | W 6-5 | 70-79 | 5 | 6,824 | Jesse Jefferson | Dennis Leonard | Jesse Jefferson | Dennis Leonard | Rich Gossage | 612 | 643 | -31 |
| 1975-09-17 | vs OAK | 150 | W 3-2 | 71-79 | 5 | 4,761 | Wilbur Wood | Ken Holtzman | Wilbur Wood | Ken Holtzman | Dave Hamilton | 615 | 645 | -30 |
| 1975-09-18 | vs OAK | 151 | L 6-7 | 71-80 | 5 | 5,781 | Jim Kaat | Dick Bosman | Jim Todd | Jim Kaat | Rollie Fingers | 621 | 652 | -31 |
| 1975-09-19 | vs TEX | 152 | L 6-10 | 71-81 | 5 | 3,723 | Claude Osteen | Steve Hargan | Steve Hargan | Claude Osteen | Stan Thomas | 627 | 662 | -35 |
| 1975-09-20 | vs TEX | 153 | L 3-5 | 71-82 | 5 | 4,732 | Jesse Jefferson | Fergie Jenkins | Fergie Jenkins | Jesse Jefferson | | 630 | 667 | -37 |
| 1975-09-21 | vs TEX | 154 | L 2-8 | 71-83 | 5 | 4,174 | Wilbur Wood | Gaylord Perry | Gaylord Perry | Wilbur Wood | | 632 | 675 | -43 |
| 1975-09-22 | @ CAL | 155 | L 0-3 | 71-84 | 6 | 6,173 | Jim Kaat | Frank Tanana | Don Kirkwood | Rich Gossage | | 632 | 678 | -46 |
| 1975-09-23 | @ CAL | 156 | W 5-4 | 72-84 | 5 | 6,078 | Claude Osteen | Joe Pactwa | Ozzie Osborn | Dick Lange | Dave Hamilton | 637 | 682 | -45 |
| 1975-09-24 | @ OAK | 157 | L 2-13 | 72-85 | 5 | 7,412 | Jesse Jefferson | Vida Blue | Vida Blue | Jesse Jefferson | | 639 | 695 | -56 |
| 1975-09-25 | @ OAK | 158 | W 8-2 | 73-85 | 5 | 2,663 | Wilbur Wood | Craig Mitchell | Wilbur Wood | Craig Mitchell | | 647 | 697 | -50 |
| 1975-09-26 | @ MIN | 159 | L 1-2 | 73-86 | 5 | 2,769 | Jim Kaat | Eddie Bane | Eddie Bane | Jim Kaat | Bill Campbell | 648 | 699 | -51 |
| 1975-09-27 | @ MIN | 160 | W 1-0 | 74-86 | 5 | 4,463 | Claude Osteen | Bert Blyleven | Rich Gossage | Bert Blyleven | | 649 | 699 | -50 |
| 1975-09-28 | @ MIN | 161 | W 6-4 | 75-86 | 5 | 4,279 | Jesse Jefferson | Jim Hughes | Dave Hamilton | Tom Burgmeier | | 655 | 703 | -48 |