| 1975-04-10 | vs PIT | 1 | L 4-8 | 0-1 | 6 | 19,239 | Bill Bonham | Dock Ellis | Dave Giusti | Ken Frailing | | 4 | 8 | -4 |
| 1975-04-11 | vs MON | 2 | W 2-1 | 1-1 | 3 | 2,109 | Ray Burris | Dennis Blair | Ray Burris | Dennis Blair | | 6 | 9 | -3 |
| 1975-04-12 | vs MON | 3 | W 6-3 | 2-1 | 3 | 11,415 | Burt Hooton | Dave McNally | Oscar Zamora | Dale Murray | | 12 | 12 | 0 |
| 1975-04-13 | vs MON | 4 | W 7-0 | 3-1 | 2 | 12,433 | Steve Stone | Steve Rogers | Steve Stone | Steve Rogers | | 19 | 12 | 7 |
| 1975-04-14 | @ PIT | 5 | W 4-2 | 4-1 | 1 | 4,780 | Rick Reuschel | Bob Moose | Rick Reuschel | Bob Moose | Darold Knowles | 23 | 14 | 9 |
| 1975-04-16 | @ PHI | 6 | W 9-3 | 5-1 | 1 | 8,294 | Bill Bonham | Steve Carlton | Bill Bonham | Steve Carlton | | 32 | 17 | 15 |
| 1975-04-17 | @ PHI | 7 | W 10-9 | 6-1 | 1 | 6,259 | Ray Burris | Wayne Twitchell | Ken Frailing | Wayne Twitchell | | 42 | 26 | 16 |
| 1975-04-19 | @ NYN | 8 | W 4-2 | 7-1 | 1 | 28,754 | Steve Stone | Tom Seaver | Steve Stone | Tom Seaver | Darold Knowles | 46 | 28 | 18 |
| 1975-04-20 | @ NYN | 9 | L 6-8 | 7-3 | 1 | 0 | Rick Reuschel | Jon Matlack | Jon Matlack | Rick Reuschel | Bob Apodaca | 52 | 36 | 16 |
| 1975-04-20 | @ NYN | 10 | L 3-4 | 7-3 | 1 | 26,693 | Burt Hooton | Randy Tate | Randy Tate | Burt Hooton | Rick Baldwin | 55 | 40 | 15 |
| 1975-04-22 | vs PHI | 11 | L 5-7 | 7-4 | 1 | 6,525 | Bill Bonham | Wayne Twitchell | Wayne Twitchell | Bill Bonham | | 60 | 47 | 13 |
| 1975-04-23 | vs PHI | 12 | W 9-3 | 8-4 | 1 | 3,228 | Ray Burris | Tom Underwood | Ray Burris | Tom Underwood | Oscar Zamora | 69 | 50 | 19 |
| 1975-04-24 | vs PHI | 13 | W 4-1 | 9-4 | 1 | 2,323 | Steve Stone | Jim Lonborg | Steve Stone | Jim Lonborg | | 73 | 51 | 22 |
| 1975-04-25 | vs SLN | 14 | W 4-3 | 10-4 | 1 | 7,466 | Rick Reuschel | Bob Forsch | Darold Knowles | Al Hrabosky | | 77 | 54 | 23 |
| 1975-04-26 | vs SLN | 15 | W 8-6 | 11-4 | 1 | 20,874 | Bill Bonham | John Denny | Ken Frailing | John Curtis | Oscar Zamora | 85 | 60 | 25 |
| 1975-04-29 | vs NYN | 16 | L 1-9 | 11-5 | 1 | 8,539 | Burt Hooton | Tom Seaver | Tom Seaver | Burt Hooton | | 86 | 69 | 17 |
| 1975-04-30 | vs NYN | 17 | W 7-4 | 12-5 | 1 | 4,802 | Ray Burris | Jon Matlack | Ray Burris | Jon Matlack | Oscar Zamora | 93 | 73 | 20 |
| 1975-05-01 | vs NYN | 18 | W 5-2 | 13-5 | 1 | 5,637 | Steve Stone | Randy Tate | Steve Stone | Randy Tate | Darold Knowles | 98 | 75 | 23 |
| 1975-05-02 | @ SLN | 19 | L 1-5 | 13-6 | 1 | 23,017 | Rick Reuschel | Bob Forsch | Bob Forsch | Rick Reuschel | | 99 | 80 | 19 |
| 1975-05-03 | @ SLN | 20 | W 7-3 | 14-6 | 1 | 24,224 | Bill Bonham | John Denny | Bill Bonham | Mike Garman | Darold Knowles | 106 | 83 | 23 |
| 1975-05-04 | @ SLN | 21 | W 8-6 | 15-6 | 1 | 22,980 | Geoff Zahn | Lynn McGlothen | Oscar Zamora | Lynn McGlothen | Darold Knowles | 114 | 89 | 25 |
| 1975-05-05 | @ MON | 22 | L 2-3 | 15-7 | 1 | 7,463 | Ray Burris | Dennis Blair | Dennis Blair | Ray Burris | Chuck Taylor | 116 | 92 | 24 |
| 1975-05-06 | @ MON | 23 | L 4-9 | 15-8 | 1 | 5,164 | Rick Reuschel | Steve Rogers | Steve Rogers | Rick Reuschel | Chuck Taylor | 120 | 101 | 19 |
| 1975-05-07 | @ MON | 24 | W 7-0 | 16-8 | 1 | 6,430 | Bill Bonham | Dave McNally | Bill Bonham | Dave McNally | | 127 | 101 | 26 |
| 1975-05-09 | vs SDN | 25 | W 5-2 | 17-8 | 1 | 6,885 | Ray Burris | Joe McIntosh | Ray Burris | Joe McIntosh | Darold Knowles | 132 | 103 | 29 |
| 1975-05-10 | vs SDN | 26 | W 5-1 | 18-8 | 1 | 20,209 | Rick Reuschel | Sonny Siebert | Rick Reuschel | Sonny Siebert | Geoff Zahn | 137 | 104 | 33 |
| 1975-05-11 | vs SDN | 27 | L 1-2 | 18-9 | 1 | 19,145 | Bill Bonham | Dave Freisleben | Dave Freisleben | Bill Bonham | | 138 | 106 | 32 |
| 1975-05-13 | vs HOU | 28 | W 2-1 | 19-9 | 1 | 9,164 | Steve Stone | Doug Konieczny | Steve Stone | Doug Konieczny | Oscar Zamora | 140 | 107 | 33 |
| 1975-05-14 | vs HOU | 29 | L 7-11 | 19-10 | 1 | 8,087 | Ray Burris | Tom Griffin | Tom Griffin | Ray Burris | Joe Niekro | 147 | 118 | 29 |
| 1975-05-15 | vs HOU | 30 | W 4-2 | 20-10 | 1 | 6,406 | Rick Reuschel | J.R. Richard | Rick Reuschel | J.R. Richard | | 151 | 120 | 31 |
| 1975-05-16 | @ SDN | 31 | L 2-8 | 20-11 | 1 | 11,484 | Bill Bonham | Joe McIntosh | Joe McIntosh | Bill Bonham | | 153 | 128 | 25 |
| 1975-05-17 | @ SDN | 32 | L 1-4 | 20-12 | 1 | 49,599 | Steve Stone | Dave Freisleben | Dave Freisleben | Darold Knowles | | 154 | 132 | 22 |
| 1975-05-18 | @ SDN | 33 | W 3-2 | 21-12 | 1 | 16,051 | Ray Burris | Dan Spillner | Ray Burris | Dan Spillner | Oscar Zamora | 157 | 134 | 23 |
| 1975-05-19 | @ LAN | 34 | L 2-3 | 21-13 | 1 | 21,790 | Rick Reuschel | Doug Rau | Jim Brewer | Darold Knowles | | 159 | 137 | 22 |
| 1975-05-20 | @ LAN | 35 | W 2-1 | 22-13 | 1 | 24,526 | Bill Bonham | Don Sutton | Bill Bonham | Don Sutton | | 161 | 138 | 23 |
| 1975-05-21 | @ LAN | 36 | L 0-10 | 22-14 | 1 | 32,315 | Geoff Zahn | Andy Messersmith | Andy Messersmith | Geoff Zahn | | 161 | 148 | 13 |
| 1975-05-22 | @ LAN | 37 | L 3-8 | 22-15 | 1 | 23,579 | Ray Burris | Burt Hooton | Burt Hooton | Ray Burris | | 164 | 156 | 8 |
| 1975-05-23 | @ SFN | 38 | L 2-3 | 22-16 | 1 | 2,675 | Rick Reuschel | Pete Falcone | Pete Falcone | Rick Reuschel | Gary Lavelle | 166 | 159 | 7 |
| 1975-05-24 | @ SFN | 39 | L 3-10 | 22-17 | 1 | 6,655 | Bill Bonham | Jim Barr | Jim Barr | Bill Bonham | | 169 | 169 | 0 |
| 1975-05-25 | @ SFN | 40 | L 7-9 | 22-18 | 1 | 12,341 | Geoff Zahn | Mike Caldwell | Charlie Williams | Ken Frailing | Gary Lavelle | 176 | 178 | -2 |
| 1975-05-26 | vs ATL | 41 | W 6-0 | 23-18 | 1 | 18,993 | Ray Burris | Roric Harrison | Ray Burris | Roric Harrison | | 182 | 178 | 4 |
| 1975-05-27 | vs ATL | 42 | L 2-7 | 23-19 | 1 | 10,731 | Rick Reuschel | Phil Niekro | Phil Niekro | Rick Reuschel | | 184 | 185 | -1 |
| 1975-05-28 | vs ATL | 43 | W 5-4 | 24-19 | 1 | 10,085 | Bill Bonham | Carl Morton | Oscar Zamora | Carl Morton | | 189 | 189 | 0 |
| 1975-05-30 | vs LAN | 44 | L 1-3 | 24-20 | 2 | 21,197 | Ray Burris | Don Sutton | Don Sutton | Ray Burris | Andy Messersmith | 190 | 192 | -2 |
| 1975-05-31 | vs LAN | 45 | W 2-1 | 25-20 | 2 | 21,344 | Rick Reuschel | Andy Messersmith | Rick Reuschel | Andy Messersmith | | 192 | 193 | -1 |
| 1975-06-01 | vs LAN | 46 | W 7-2 | 26-20 | 1 | 31,325 | Bill Bonham | Burt Hooton | Bill Bonham | Burt Hooton | Oscar Zamora | 199 | 195 | 4 |
| 1975-06-03 | vs SFN | 47 | W 6-5 | 27-20 | 1 | 11,082 | Ray Burris | Ed Halicki | Geoff Zahn | Randy Moffitt | | 205 | 200 | 5 |
| 1975-06-04 | vs SFN | 48 | L 8-10 | 27-21 | 1 | 9,126 | Rick Reuschel | John Montefusco | Charlie Williams | Oscar Zamora | Mike Caldwell | 213 | 210 | 3 |
| 1975-06-05 | vs SFN | 49 | W 8-4 | 28-21 | 1 | 13,211 | Steve Stone | Pete Falcone | Darold Knowles | Randy Moffitt | | 221 | 214 | 7 |
| 1975-06-06 | @ CIN | 50 | L 1-5 | 28-22 | 2 | 38,030 | Bill Bonham | Don Gullett | Don Gullett | Bill Bonham | | 222 | 219 | 3 |
| 1975-06-07 | @ CIN | 51 | L 1-8 | 28-23 | 2 | 47,340 | Ray Burris | Jack Billingham | Jack Billingham | Ray Burris | | 223 | 227 | -4 |
| 1975-06-08 | @ CIN | 52 | L 1-2 | 28-25 | 4 | 0 | Rick Reuschel | Gary Nolan | Gary Nolan | Rick Reuschel | | 224 | 229 | -5 |
| 1975-06-08 | @ CIN | 53 | L 5-8 | 28-25 | 4 | 50,311 | Geoff Zahn | Clay Kirby | Pedro Borbon | Geoff Zahn | Will McEnaney | 229 | 237 | -8 |
| 1975-06-09 | @ HOU | 54 | W 4-3 | 29-25 | 2 | 3,427 | Steve Stone | Tom Griffin | Oscar Zamora | Wayne Granger | Darold Knowles | 233 | 240 | -7 |
| 1975-06-10 | @ HOU | 55 | L 3-4 | 29-26 | 4 | 7,542 | Bill Bonham | Doug Konieczny | Doug Konieczny | Eddie Watt | | 236 | 244 | -8 |
| 1975-06-12 | @ ATL | 56 | L 4-5 | 29-28 | 4 | 0 | Ray Burris | Phil Niekro | Tom House | Ken Frailing | | 240 | 249 | -9 |
| 1975-06-12 | @ ATL | 57 | L 2-6 | 29-28 | 4 | 5,360 | Geoff Zahn | Carl Morton | Carl Morton | Geoff Zahn | | 242 | 255 | -13 |
| 1975-06-13 | vs CIN | 58 | L 11-18 | 29-29 | 4 | 17,488 | Rick Reuschel | Jack Billingham | Pedro Borbon | Oscar Zamora | | 253 | 273 | -20 |
| 1975-06-14 | vs CIN | 59 | L 3-11 | 29-30 | 4 | 28,134 | Steve Stone | Clay Kirby | Clay Kirby | Steve Stone | | 256 | 284 | -28 |
| 1975-06-15 | vs CIN | 60 | W 4-3 | 30-30 | 4 | 18,575 | Bill Bonham | Pat Darcy | Bill Bonham | Pat Darcy | Oscar Zamora | 260 | 287 | -27 |
| 1975-06-16 | vs PHI | 61 | W 9-7 | 31-30 | 4 | 9,353 | Ray Burris | Steve Carlton | Geoff Zahn | Gene Garber | Ken Frailing | 269 | 294 | -25 |
| 1975-06-17 | vs PHI | 62 | W 9-5 | 32-30 | 4 | 6,834 | Rick Reuschel | Jim Lonborg | Tom Dettore | Jim Lonborg | | 278 | 299 | -21 |
| 1975-06-18 | vs PHI | 63 | L 7-9 | 32-31 | 4 | 20,807 | Steve Stone | Wayne Twitchell | Gene Garber | Bob Locker | | 285 | 308 | -23 |
| 1975-06-19 | vs PHI | 64 | L 3-6 | 32-32 | 4 | 15,170 | Bill Bonham | Larry Christenson | Tug McGraw | Darold Knowles | | 288 | 314 | -26 |
| 1975-06-20 | @ SLN | 65 | L 3-8 | 32-33 | 4 | 25,841 | Geoff Zahn | Bob Forsch | Bob Forsch | Geoff Zahn | | 291 | 322 | -31 |
| 1975-06-21 | @ SLN | 66 | W 6-1 | 33-33 | 4 | 42,914 | Rick Reuschel | Bob Gibson | Rick Reuschel | Bob Gibson | | 297 | 323 | -26 |
| 1975-06-22 | @ SLN | 67 | L 2-7 | 33-34 | 4 | 35,102 | Steve Stone | Lynn McGlothen | Lynn McGlothen | Steve Stone | | 299 | 330 | -31 |
| 1975-06-23 | @ MON | 68 | W 6-0 | 34-34 | 3 | 12,281 | Ray Burris | Fred Scherman | Ray Burris | Fred Scherman | | 305 | 330 | -25 |
| 1975-06-24 | @ MON | 69 | W 13-6 | 35-34 | 4 | 17,021 | Bill Bonham | Dan Warthen | Bill Bonham | Dan Warthen | | 318 | 336 | -18 |
| 1975-06-25 | @ MON | 70 | L 6-12 | 35-35 | 4 | 9,680 | Rick Reuschel | Dennis Blair | Dennis Blair | Rick Reuschel | | 324 | 348 | -24 |
| 1975-06-26 | @ PIT | 71 | L 2-5 | 35-36 | 4 | 10,394 | Steve Stone | John Candelaria | John Candelaria | Ken Frailing | | 326 | 353 | -27 |
| 1975-06-27 | @ PIT | 72 | L 1-5 | 35-38 | 5 | 0 | Geoff Zahn | Dock Ellis | Dock Ellis | Geoff Zahn | | 327 | 358 | -31 |
| 1975-06-27 | @ PIT | 73 | L 3-5 | 35-38 | 5 | 34,972 | Ray Burris | Ken Brett | Ramon Hernandez | Darold Knowles | Dave Giusti | 330 | 363 | -33 |
| 1975-06-28 | @ PIT | 74 | W 1-0 | 36-38 | 5 | 16,477 | Bill Bonham | Jim Rooker | Bill Bonham | Jim Rooker | | 331 | 363 | -32 |
| 1975-06-29 | @ PIT | 75 | L 3-4 | 36-40 | 5 | 0 | Rick Reuschel | Bruce Kison | Dave Giusti | Rick Reuschel | | 334 | 367 | -33 |
| 1975-06-29 | @ PIT | 76 | L 0-7 | 36-40 | 5 | 37,145 | Tom Dettore | Jerry Reuss | Jerry Reuss | Tom Dettore | | 334 | 374 | -40 |
| 1975-06-30 | @ NYN | 77 | L 1-5 | 36-41 | 5 | 14,742 | Steve Stone | George Stone | George Stone | Steve Stone | | 335 | 379 | -44 |
| 1975-07-01 | @ NYN | 78 | W 5-4 | 37-41 | 5 | 16,822 | Ray Burris | Hank Webb | Tom Dettore | Rick Baldwin | | 340 | 383 | -43 |
| 1975-07-02 | @ NYN | 79 | L 2-7 | 37-42 | 5 | 16,055 | Bill Bonham | Jon Matlack | Jon Matlack | Bill Bonham | | 342 | 390 | -48 |
| 1975-07-03 | @ NYN | 80 | L 0-4 | 37-43 | 5 | 17,299 | Rick Reuschel | Jerry Koosman | Jerry Koosman | Rick Reuschel | | 342 | 394 | -52 |
| 1975-07-04 | vs PIT | 81 | W 6-1 | 39-43 | 5 | 0 | Steve Stone | Bruce Kison | Steve Stone | Bruce Kison | | 348 | 395 | -47 |
| 1975-07-04 | vs PIT | 82 | W 2-1 | 39-43 | 5 | 30,355 | Geoff Zahn | Jerry Reuss | Darold Knowles | Jerry Reuss | | 350 | 396 | -46 |
| 1975-07-05 | vs PIT | 83 | L 4-5 | 39-44 | 5 | 22,393 | Ray Burris | Jim Rooker | Jim Rooker | Ray Burris | Ramon Hernandez | 354 | 401 | -47 |
| 1975-07-06 | vs PIT | 84 | L 12-18 | 39-45 | 5 | 28,023 | Bill Bonham | Larry Demery | Ramon Hernandez | Ken Frailing | | 366 | 419 | -53 |
| 1975-07-07 | vs PIT | 85 | L 0-5 | 39-46 | 5 | 16,540 | Rick Reuschel | Ken Brett | Ken Brett | Rick Reuschel | Dave Giusti | 366 | 424 | -58 |
| 1975-07-08 | vs SDN | 86 | L 6-8 | 39-47 | 5 | 12,240 | Steve Stone | Randy Jones | Joe McIntosh | Tom Dettore | | 372 | 432 | -60 |
| 1975-07-09 | vs SDN | 87 | L 2-3 | 39-48 | 5 | 14,301 | Geoff Zahn | Brent Strom | Brent Strom | Geoff Zahn | Bill Greif | 374 | 435 | -61 |
| 1975-07-10 | vs SDN | 88 | W 3-1 | 40-48 | 5 | 10,724 | Ray Burris | Dave Freisleben | Ray Burris | Dave Freisleben | | 377 | 436 | -59 |
| 1975-07-11 | vs SFN | 89 | W 8-6 | 41-48 | 5 | 13,415 | Bill Bonham | Ed Halicki | Tom Dettore | Randy Moffitt | Darold Knowles | 385 | 442 | -57 |
| 1975-07-12 | vs SFN | 90 | W 6-4 | 42-48 | 5 | 17,155 | Steve Stone | Mike Caldwell | Steve Stone | Mike Caldwell | | 391 | 446 | -55 |
| 1975-07-13 | vs SFN | 91 | L 1-4 | 42-49 | 5 | 22,868 | Geoff Zahn | John Montefusco | John Montefusco | Geoff Zahn | Charlie Williams | 392 | 450 | -58 |
| 1975-07-17 | @ SDN | 92 | W 6-5 | 43-49 | 5 | 10,647 | Rick Reuschel | Brent Strom | Rick Reuschel | Brent Strom | Darold Knowles | 398 | 455 | -57 |
| 1975-07-18 | @ SDN | 93 | L 2-4 | 43-50 | 5 | 14,151 | Ray Burris | Randy Jones | Bill Greif | Milt Wilcox | Danny Frisella | 400 | 459 | -59 |
| 1975-07-19 | @ SDN | 94 | L 1-2 | 43-51 | 5 | 20,251 | Steve Stone | Dave Freisleben | Dave Freisleben | Steve Stone | | 401 | 461 | -60 |
| 1975-07-20 | @ LAN | 95 | L 3-5 | 43-52 | 5 | 42,800 | Bill Bonham | Burt Hooton | Mike Marshall | Tom Dettore | | 404 | 466 | -62 |
| 1975-07-21 | @ LAN | 96 | W 1-0 | 44-52 | 5 | 24,147 | Rick Reuschel | Andy Messersmith | Rick Reuschel | Andy Messersmith | Oscar Zamora | 405 | 466 | -61 |
| 1975-07-22 | @ SFN | 97 | L 5-9 | 44-53 | 5 | 3,639 | Ray Burris | Pete Falcone | Charlie Williams | Ray Burris | Randy Moffitt | 410 | 475 | -65 |
| 1975-07-23 | @ SFN | 98 | L 2-10 | 44-54 | 5 | 6,526 | Steve Stone | John Montefusco | John Montefusco | Steve Stone | | 412 | 485 | -73 |
| 1975-07-24 | @ SFN | 99 | W 4-3 | 45-54 | 5 | 5,501 | Bill Bonham | Ed Halicki | Bill Bonham | Ed Halicki | Oscar Zamora | 416 | 488 | -72 |
| 1975-07-25 | vs NYN | 100 | L 3-6 | 45-55 | 5 | 15,040 | Rick Reuschel | Randy Tate | Randy Tate | Rick Reuschel | Ken Sanders | 419 | 494 | -75 |
| 1975-07-26 | vs NYN | 101 | L 8-9 | 45-56 | 5 | 20,474 | Ray Burris | George Stone | Tom Hall | Darold Knowles | Rick Baldwin | 427 | 503 | -76 |
| 1975-07-27 | vs NYN | 102 | W 4-2 | 46-57 | 5 | 0 | Steve Stone | Jerry Koosman | Steve Stone | Jerry Koosman | | 431 | 505 | -74 |
| 1975-07-27 | vs NYN | 103 | L 1-4 | 46-57 | 5 | 29,774 | Tom Dettore | Hank Webb | Hank Webb | Paul Reuschel | Ken Sanders | 432 | 509 | -77 |
| 1975-07-28 | vs MON | 104 | W 4-2 | 47-57 | 5 | 7,310 | Bill Bonham | Dennis Blair | Bill Bonham | Dennis Blair | | 436 | 511 | -75 |
| 1975-07-29 | vs MON | 105 | W 4-3 | 48-57 | 5 | 13,209 | Rick Reuschel | Steve Renko | Darold Knowles | Dale Murray | Oscar Zamora | 440 | 514 | -74 |
| 1975-07-30 | vs MON | 106 | L 1-6 | 48-58 | 5 | 11,117 | Ray Burris | Steve Rogers | Steve Rogers | Ray Burris | | 441 | 520 | -79 |
| 1975-07-31 | vs SLN | 107 | W 5-3 | 49-58 | 5 | 19,058 | Steve Stone | Eric Rasmussen | Paul Reuschel | Ken Reynolds | | 446 | 523 | -77 |
| 1975-08-01 | vs SLN | 108 | L 4-9 | 49-59 | 5 | 18,038 | Bill Bonham | John Denny | John Denny | Bill Bonham | Bob Gibson | 450 | 532 | -82 |
| 1975-08-02 | vs SLN | 109 | L 0-4 | 49-60 | 5 | 17,524 | Rick Reuschel | Bob Forsch | Bob Forsch | Rick Reuschel | | 450 | 536 | -86 |
| 1975-08-03 | vs SLN | 110 | W 6-3 | 50-61 | 5 | 0 | Tom Dettore | Lynn McGlothen | Tom Dettore | Al Hrabosky | Darold Knowles | 456 | 539 | -83 |
| 1975-08-03 | vs SLN | 111 | L 4-7 | 50-61 | 5 | 32,691 | Ray Burris | Ron Reed | Ron Reed | Ray Burris | | 460 | 546 | -86 |
| 1975-08-04 | @ PHI | 112 | W 3-2 | 51-61 | 5 | 16,285 | Steve Stone | Wayne Twitchell | Steve Stone | Tom Hilgendorf | Paul Reuschel | 463 | 548 | -85 |
| 1975-08-05 | @ PHI | 113 | L 5-13 | 51-62 | 5 | 19,611 | Bill Bonham | Dick Ruthven | Dick Ruthven | Bill Bonham | | 468 | 561 | -93 |
| 1975-08-07 | @ PHI | 114 | W 5-3 | 52-62 | 5 | 20,259 | Rick Reuschel | Larry Christenson | Rick Reuschel | Larry Christenson | | 473 | 564 | -91 |
| 1975-08-08 | @ ATL | 115 | L 0-1 | 53-63 | 5 | 0 | Tom Dettore | Carl Morton | Carl Morton | Tom Dettore | | 473 | 565 | -92 |
| 1975-08-08 | @ ATL | 116 | W 3-1 | 53-63 | 5 | 8,368 | Ray Burris | Bruce Dal Canton | Ray Burris | Bruce Dal Canton | Darold Knowles | 476 | 566 | -90 |
| 1975-08-09 | @ ATL | 117 | W 8-2 | 54-63 | 5 | 22,605 | Steve Stone | Phil Niekro | Steve Stone | Phil Niekro | | 484 | 568 | -84 |
| 1975-08-10 | @ ATL | 118 | W 9-1 | 55-63 | 5 | 4,251 | Bill Bonham | Blue Moon Odom | Bill Bonham | Blue Moon Odom | | 493 | 569 | -76 |
| 1975-08-11 | @ CIN | 119 | L 3-9 | 55-64 | 5 | 27,725 | Rick Reuschel | Jack Billingham | Jack Billingham | Rick Reuschel | | 496 | 578 | -82 |
| 1975-08-12 | @ CIN | 120 | L 8-12 | 55-65 | 5 | 31,550 | Tom Dettore | Pat Darcy | Rawly Eastwick | Darold Knowles | | 504 | 590 | -86 |
| 1975-08-14 | @ HOU | 121 | W 5-3 | 56-65 | 5 | 7,555 | Steve Stone | J.R. Richard | Steve Stone | J.R. Richard | | 509 | 593 | -84 |
| 1975-08-15 | @ HOU | 122 | L 1-4 | 56-66 | 5 | 10,496 | Bill Bonham | Larry Dierker | Larry Dierker | Bill Bonham | | 510 | 597 | -87 |
| 1975-08-16 | @ HOU | 123 | W 3-2 | 57-66 | 5 | 7,039 | Rick Reuschel | Dave Roberts | Rick Reuschel | Dave Roberts | | 513 | 599 | -86 |
| 1975-08-17 | @ HOU | 124 | W 11-7 | 58-66 | 5 | 8,769 | Ray Burris | Jim Crawford | Ray Burris | Jim Crawford | | 524 | 606 | -82 |
| 1975-08-18 | vs LAN | 125 | L 1-3 | 58-67 | 5 | 14,383 | Steve Stone | Burt Hooton | Burt Hooton | Steve Stone | Mike Marshall | 525 | 609 | -84 |
| 1975-08-19 | vs LAN | 126 | L 1-2 | 58-68 | 5 | 17,594 | Bill Bonham | Don Sutton | Mike Marshall | Bill Bonham | | 526 | 611 | -85 |
| 1975-08-21 | vs LAN | 127 | W 7-0 | 59-68 | 5 | 8,377 | Rick Reuschel | Andy Messersmith | Rick Reuschel | Andy Messersmith | | 533 | 611 | -78 |
| 1975-08-22 | vs HOU | 128 | W 6-5 | 60-68 | 5 | 9,602 | Steve Stone | J.R. Richard | Darold Knowles | Jim Crawford | | 539 | 616 | -77 |
| 1975-08-23 | vs HOU | 129 | L 12-14 | 60-69 | 5 | 17,391 | Bill Bonham | Jim York | Jim York | Bill Bonham | Mike Cosgrove | 551 | 630 | -79 |
| 1975-08-24 | vs HOU | 130 | L 4-8 | 60-70 | 5 | 19,795 | Ray Burris | Larry Dierker | Larry Dierker | Ray Burris | | 555 | 638 | -83 |
| 1975-08-25 | vs CIN | 131 | L 4-11 | 60-71 | 5 | 12,267 | Rick Reuschel | Fred Norman | Fred Norman | Rick Reuschel | Clay Carroll | 559 | 649 | -90 |
| 1975-08-26 | vs CIN | 132 | L 5-6 | 60-72 | 5 | 19,045 | Steve Stone | Jack Billingham | Rawly Eastwick | Steve Stone | Will McEnaney | 564 | 655 | -91 |
| 1975-08-27 | vs CIN | 133 | L 5-6 | 60-73 | 5 | 17,744 | Bill Bonham | Pat Darcy | Pedro Borbon | Bill Bonham | Rawly Eastwick | 569 | 661 | -92 |
| 1975-08-29 | vs ATL | 134 | W 8-3 | 61-73 | 5 | 4,151 | Ray Burris | Carl Morton | Ray Burris | Carl Morton | | 577 | 664 | -87 |
| 1975-08-31 | vs ATL | 135 | L 1-3 | 62-74 | 5 | 0 | Rick Reuschel | Phil Niekro | Phil Niekro | Rick Reuschel | | 578 | 667 | -89 |
| 1975-08-31 | vs ATL | 136 | W 9-8 | 62-74 | 5 | 12,346 | Steve Stone | Mike Thompson | Tom Dettore | Ray Sadecki | | 587 | 675 | -88 |
| 1975-09-01 | @ SLN | 137 | L 3-6 | 62-75 | 5 | 48,435 | Bill Bonham | Bob Forsch | Bob Forsch | Bill Bonham | Al Hrabosky | 590 | 681 | -91 |
| 1975-09-02 | @ SLN | 138 | W 5-3 | 63-75 | 5 | 13,049 | Ray Burris | Lynn McGlothen | Ray Burris | Lynn McGlothen | Paul Reuschel | 595 | 684 | -89 |
| 1975-09-03 | @ SLN | 139 | W 11-6 | 64-75 | 5 | 14,119 | Willie Prall | Ron Reed | Buddy Schultz | Bob Gibson | Paul Reuschel | 606 | 690 | -84 |
| 1975-09-05 | @ PHI | 140 | W 4-3 | 65-76 | 5 | 0 | Bill Bonham | Steve Carlton | Bill Bonham | Steve Carlton | Paul Reuschel | 610 | 693 | -83 |
| 1975-09-05 | @ PHI | 141 | L 3-6 | 65-76 | 5 | 32,041 | Rick Reuschel | Wayne Simpson | Tug McGraw | Paul Reuschel | | 613 | 699 | -86 |
| 1975-09-06 | @ PHI | 142 | W 7-6 | 66-76 | 5 | 26,554 | Steve Stone | Larry Christenson | Steve Stone | Gene Garber | Darold Knowles | 620 | 705 | -85 |
| 1975-09-07 | @ PHI | 143 | W 6-4 | 67-76 | 5 | 30,071 | Ray Burris | Wayne Twitchell | Ray Burris | Wayne Twitchell | Rick Reuschel | 626 | 709 | -83 |
| 1975-09-08 | @ PIT | 144 | L 1-4 | 67-77 | 5 | 6,756 | Willie Prall | Dock Ellis | Dock Ellis | Willie Prall | Ramon Hernandez | 627 | 713 | -86 |
| 1975-09-09 | @ PIT | 145 | W 6-5 | 68-77 | 5 | 7,346 | Bill Bonham | Bruce Kison | Bill Bonham | Larry Demery | Paul Reuschel | 633 | 718 | -85 |
| 1975-09-10 | vs SLN | 146 | W 7-5 | 69-77 | 5 | 5,031 | Steve Stone | Eric Rasmussen | Buddy Schultz | Eric Rasmussen | Darold Knowles | 640 | 723 | -83 |
| 1975-09-11 | vs SLN | 147 | W 12-6 | 70-77 | 5 | 3,635 | Rick Reuschel | Bob Forsch | Oscar Zamora | Bob Forsch | Darold Knowles | 652 | 729 | -77 |
| 1975-09-13 | vs PHI | 148 | W 4-1 | 71-77 | 5 | 13,283 | Ray Burris | Tom Underwood | Ray Burris | Tom Underwood | | 656 | 730 | -74 |
| 1975-09-14 | vs PHI | 149 | L 7-13 | 71-78 | 5 | 16,294 | Steve Stone | Steve Carlton | Steve Carlton | Steve Stone | | 663 | 743 | -80 |
| 1975-09-15 | vs PIT | 150 | W 6-5 | 72-79 | 5 | 0 | Bill Bonham | Jerry Reuss | Darold Knowles | Dave Giusti | | 669 | 748 | -79 |
| 1975-09-15 | vs PIT | 151 | L 1-9 | 72-79 | 5 | 5,432 | Willie Prall | Jim Rooker | Jim Rooker | Willie Prall | | 670 | 757 | -87 |
| 1975-09-16 | vs PIT | 152 | L 0-22 | 72-80 | 5 | 4,932 | Rick Reuschel | John Candelaria | John Candelaria | Rick Reuschel | | 670 | 779 | -109 |
| 1975-09-17 | @ NYN | 153 | W 5-2 | 73-80 | 5 | 7,568 | Ray Burris | Craig Swan | Ray Burris | Craig Swan | | 675 | 781 | -106 |
| 1975-09-18 | @ NYN | 154 | L 5-7 | 73-81 | 5 | 6,336 | Donnie Moore | Hank Webb | Ken Sanders | Darold Knowles | | 680 | 788 | -108 |
| 1975-09-19 | @ MON | 155 | L 6-9 | 73-82 | 5 | 5,201 | Bill Bonham | Steve Rogers | Dale Murray | Bill Bonham | | 686 | 797 | -111 |
| 1975-09-20 | @ MON | 156 | L 1-3 | 73-83 | 5 | 8,595 | Rick Reuschel | Don Carrithers | Don Carrithers | Rick Reuschel | | 687 | 800 | -113 |
| 1975-09-21 | @ MON | 157 | L 4-5 | 73-84 | 5 | 20,790 | Steve Stone | Dennis Blair | Dale Murray | Paul Reuschel | | 691 | 805 | -114 |
| 1975-09-23 | vs NYN | 158 | L 6-8 | 73-85 | 5 | 2,443 | Ray Burris | Craig Swan | Bob Apodaca | Darold Knowles | Ken Sanders | 697 | 813 | -116 |
| 1975-09-24 | vs NYN | 159 | W 1-0 | 74-85 | 5 | 2,113 | Rick Reuschel | Tom Seaver | Ken Crosby | Skip Lockwood | | 698 | 813 | -115 |
| 1975-09-26 | vs MON | 160 | L 2-3 | 74-86 | 5 | 1,427 | Steve Stone | Dan Warthen | Dale Murray | Darold Knowles | Woodie Fryman | 700 | 816 | -116 |
| 1975-09-27 | vs MON | 161 | L 3-5 | 74-87 | 6 | 7,580 | Ray Burris | Steve Rogers | Woodie Fryman | Bill Bonham | | 703 | 821 | -118 |
| 1975-09-28 | vs MON | 162 | W 9-6 | 75-87 | 5 | 9,764 | Rick Reuschel | Don Carrithers | Rick Reuschel | Don DeMola | Darold Knowles | 712 | 827 | -115 |