| 1975-04-08 | vs MIL | 1 | W 5-2 | 1-0 | 1 | 34,055 | Luis Tiant | Jim Slaton | Luis Tiant | Jim Slaton | | 5 | 2 | 3 |
| 1975-04-09 | vs MIL | 2 | L 4-7 | 1-1 | 2 | 7,643 | Bill Lee | Pete Broberg | Pete Broberg | Bill Lee | Tom Murphy | 9 | 9 | 0 |
| 1975-04-11 | @ BAL | 3 | W 6-5 | 2-1 | 1 | 38,655 | Rick Wise | Mike Cuellar | Diego Segui | Doyle Alexander | | 15 | 14 | 1 |
| 1975-04-12 | @ BAL | 4 | W 3-2 | 3-1 | 1 | 8,752 | Reggie Cleveland | Ross Grimsley | Reggie Cleveland | Jesse Jefferson | Dick Drago | 18 | 16 | 2 |
| 1975-04-13 | @ BAL | 5 | L 3-11 | 3-2 | 1 | 14,528 | Luis Tiant | Mike Torrez | Mike Torrez | Luis Tiant | | 21 | 27 | -6 |
| 1975-04-15 | @ NYA | 6 | W 5-3 | 4-2 | 1 | 7,773 | Bill Lee | Catfish Hunter | Bill Lee | Catfish Hunter | | 26 | 30 | -4 |
| 1975-04-16 | @ NYA | 7 | W 4-2 | 5-2 | 1 | 8,854 | Rick Wise | Pat Dobson | Rick Wise | Pat Dobson | | 30 | 32 | -2 |
| 1975-04-18 | vs BAL | 8 | L 7-9 | 5-3 | 1 | 8,219 | Reggie Cleveland | Ross Grimsley | Doyle Alexander | Reggie Cleveland | | 37 | 41 | -4 |
| 1975-04-20 | vs BAL | 9 | W 10-2 | 6-3 | 1 | 17,765 | Luis Tiant | Mike Torrez | Luis Tiant | Mike Torrez | | 47 | 43 | 4 |
| 1975-04-21 | vs NYA | 10 | L 1-12 | 6-4 | 1 | 28,381 | Bill Lee | Pat Dobson | Pat Dobson | Bill Lee | | 48 | 55 | -7 |
| 1975-04-22 | vs NYA | 11 | L 0-5 | 6-5 | 3 | 16,922 | Rick Wise | Doc Medich | Doc Medich | Rick Wise | | 48 | 60 | -12 |
| 1975-04-23 | vs NYA | 12 | W 11-7 | 7-5 | 1 | 22,243 | Reggie Cleveland | Catfish Hunter | Roger Moret | Sparky Lyle | Diego Segui | 59 | 67 | -8 |
| 1975-04-25 | @ DET | 13 | L 0-1 | 7-6 | 3 | 10,109 | Luis Tiant | Mickey Lolich | Mickey Lolich | Luis Tiant | | 59 | 68 | -9 |
| 1975-04-26 | @ DET | 14 | L 2-3 | 7-7 | 4 | 9,594 | Bill Lee | Vern Ruhle | John Hiller | Bill Lee | | 61 | 71 | -10 |
| 1975-04-27 | @ DET | 15 | L 4-5 | 7-8 | 4 | 17,414 | Rick Wise | Lerrin LaGrow | Lerrin LaGrow | Rick Wise | John Hiller | 65 | 76 | -11 |
| 1975-04-30 | vs CLE | 16 | L 1-8 | 7-9 | 6 | 9,307 | Luis Tiant | Gaylord Perry | Gaylord Perry | Luis Tiant | | 66 | 84 | -18 |
| 1975-05-01 | vs CLE | 17 | W 7-6 | 8-9 | 4 | 6,016 | Bill Lee | Jim Perry | Bill Lee | Jim Perry | Diego Segui | 73 | 90 | -17 |
| 1975-05-03 | vs DET | 18 | W 12-2 | 9-9 | 3 | 13,153 | Rick Wise | Lerrin LaGrow | Rick Wise | Lerrin LaGrow | | 85 | 92 | -7 |
| 1975-05-05 | @ CLE | 19 | W 7-5 | 10-9 | 3 | 7,462 | Luis Tiant | Jim Perry | Luis Tiant | Jim Perry | Dick Drago | 92 | 97 | -5 |
| 1975-05-06 | @ CLE | 20 | W 4-1 | 11-9 | 3 | 3,880 | Bill Lee | Dick Bosman | Bill Lee | Dick Bosman | | 96 | 98 | -2 |
| 1975-05-07 | @ CLE | 21 | W 4-2 | 12-9 | 2 | 4,857 | Reggie Cleveland | Fritz Peterson | Reggie Cleveland | Fritz Peterson | Diego Segui | 100 | 100 | 0 |
| 1975-05-09 | @ CAL | 22 | W 4-1 | 13-9 | 2 | 12,411 | Rick Wise | Andy Hassler | Rick Wise | Andy Hassler | | 104 | 101 | 3 |
| 1975-05-10 | @ CAL | 23 | L 0-2 | 13-10 | 2 | 43,112 | Luis Tiant | Frank Tanana | Frank Tanana | Luis Tiant | | 104 | 103 | 1 |
| 1975-05-11 | @ CAL | 24 | W 5-2 | 14-10 | 2 | 10,826 | Bill Lee | Bill Singer | Bill Lee | Bill Singer | | 109 | 105 | 4 |
| 1975-05-12 | @ OAK | 25 | L 3-5 | 14-11 | 2 | 28,984 | Reggie Cleveland | Dave Hamilton | Rollie Fingers | Diego Segui | Paul Lindblad | 112 | 110 | 2 |
| 1975-05-13 | @ OAK | 26 | L 5-9 | 14-12 | 2 | 4,239 | Rick Wise | Glenn Abbott | Ken Holtzman | Rick Wise | Jim Todd | 117 | 119 | -2 |
| 1975-05-15 | vs KCA | 27 | L 0-3 | 14-13 | 2 | 10,300 | Luis Tiant | Steve Busby | Steve Busby | Luis Tiant | | 117 | 122 | -5 |
| 1975-05-16 | vs KCA | 28 | L 2-5 | 14-14 | 2 | 12,213 | Bill Lee | Dennis Leonard | Dennis Leonard | Bill Lee | | 119 | 127 | -8 |
| 1975-05-17 | vs KCA | 29 | L 3-5 | 14-15 | 2 | 10,907 | Reggie Cleveland | Al Fitzmorris | Al Fitzmorris | Reggie Cleveland | Doug Bird | 122 | 132 | -10 |
| 1975-05-18 | vs KCA | 30 | W 4-2 | 15-15 | 2 | 16,657 | Rick Wise | Nelson Briles | Rick Wise | Nelson Briles | | 126 | 134 | -8 |
| 1975-05-19 | vs OAK | 31 | W 10-5 | 16-15 | 2 | 14,700 | Luis Tiant | Dave Hamilton | Luis Tiant | Blue Moon Odom | | 136 | 139 | -3 |
| 1975-05-20 | vs OAK | 32 | W 7-0 | 17-15 | 2 | 17,201 | Bill Lee | Vida Blue | Bill Lee | Vida Blue | | 143 | 139 | 4 |
| 1975-05-21 | vs OAK | 33 | W 7-3 | 18-15 | 2 | 14,665 | Reggie Cleveland | Ken Holtzman | Reggie Cleveland | Ken Holtzman | | 150 | 142 | 8 |
| 1975-05-22 | vs CAL | 34 | L 3-6 | 18-16 | 2 | 9,155 | Rick Wise | Bill Singer | Bill Singer | Rick Wise | | 153 | 148 | 5 |
| 1975-05-23 | vs CAL | 35 | W 6-1 | 19-16 | 2 | 20,587 | Luis Tiant | Nolan Ryan | Luis Tiant | Nolan Ryan | | 159 | 149 | 10 |
| 1975-05-24 | vs CAL | 36 | W 6-0 | 20-16 | 1 | 11,805 | Bill Lee | Andy Hassler | Bill Lee | Andy Hassler | | 165 | 149 | 16 |
| 1975-05-25 | vs CAL | 37 | L 1-6 | 20-17 | 1 | 16,401 | Reggie Cleveland | Ed Figueroa | Ed Figueroa | Reggie Cleveland | | 166 | 155 | 11 |
| 1975-05-26 | @ TEX | 38 | W 7-5 | 21-17 | 1 | 15,478 | Rick Wise | Steve Hargan | Rick Wise | Steve Foucault | Dick Drago | 173 | 160 | 13 |
| 1975-05-28 | @ TEX | 39 | W 4-1 | 22-17 | 1 | 8,091 | Bill Lee | Fergie Jenkins | Bill Lee | Fergie Jenkins | | 177 | 161 | 16 |
| 1975-05-30 | @ MIN | 40 | L 3-4 | 22-18 | 1 | 11,666 | Dick Pole | Dave Goltz | Dave Goltz | Diego Segui | Tom Burgmeier | 180 | 165 | 15 |
| 1975-05-31 | @ MIN | 41 | W 12-8 | 23-18 | 1 | 10,873 | Rick Wise | Bert Blyleven | Roger Moret | Tom Burgmeier | | 192 | 173 | 19 |
| 1975-06-01 | @ MIN | 42 | W 11-9 | 24-18 | 1 | 25,493 | Luis Tiant | Jim Hughes | Luis Tiant | Jim Hughes | Dick Drago | 203 | 182 | 21 |
| 1975-06-02 | vs CHA | 43 | L 2-9 | 24-19 | 1 | 15,681 | Bill Lee | Stan Bahnsen | Stan Bahnsen | Bill Lee | | 205 | 191 | 14 |
| 1975-06-03 | vs CHA | 44 | W 4-0 | 25-19 | 1 | 10,625 | Dick Pole | Lloyd Allen | Dick Pole | Lloyd Allen | | 209 | 191 | 18 |
| 1975-06-04 | vs CHA | 45 | W 7-6 | 26-19 | 1 | 12,366 | Rick Wise | Jim Kaat | Roger Moret | Rich Gossage | | 216 | 197 | 19 |
| 1975-06-06 | vs MIN | 46 | W 13-10 | 27-19 | 1 | 18,120 | Luis Tiant | Joe Decker | Luis Tiant | Mike Pazik | Dick Drago | 229 | 207 | 22 |
| 1975-06-07 | vs MIN | 47 | W 3-1 | 28-19 | 1 | 18,649 | Bill Lee | Ray Corbin | Bill Lee | Ray Corbin | | 232 | 208 | 24 |
| 1975-06-08 | vs MIN | 48 | L 5-7 | 28-20 | 1 | 18,301 | Dick Pole | Dave Goltz | Dave Goltz | Dick Pole | Tom Burgmeier | 237 | 215 | 22 |
| 1975-06-09 | vs TEX | 49 | L 4-12 | 28-21 | 1 | 13,597 | Rick Wise | Bill Hands | Jackie Brown | Rick Wise | | 241 | 227 | 14 |
| 1975-06-10 | vs TEX | 50 | L 3-8 | 28-22 | 1 | 20,919 | Luis Tiant | Fergie Jenkins | Fergie Jenkins | Luis Tiant | | 244 | 235 | 9 |
| 1975-06-11 | @ CHA | 51 | W 9-7 | 29-22 | 1 | 5,228 | Bill Lee | Stan Bahnsen | Roger Moret | Rich Gossage | Diego Segui | 253 | 242 | 11 |
| 1975-06-12 | @ CHA | 52 | L 2-9 | 29-23 | 1 | 5,944 | Jim Burton | Jim Kaat | Jim Kaat | Jim Burton | | 255 | 251 | 4 |
| 1975-06-13 | @ KCA | 53 | W 10-4 | 30-24 | 1 | 0 | Rick Wise | Al Fitzmorris | Rick Wise | Al Fitzmorris | | 265 | 255 | 10 |
| 1975-06-13 | @ KCA | 54 | L 5-6 | 30-24 | 1 | 25,311 | Dick Pole | Paul Splittorff | Doug Bird | Dick Pole | | 270 | 261 | 9 |
| 1975-06-14 | @ KCA | 55 | W 4-3 | 31-24 | 1 | 19,352 | Luis Tiant | Marty Pattin | Luis Tiant | Marty Pattin | | 274 | 264 | 10 |
| 1975-06-15 | @ KCA | 56 | W 8-7 | 32-24 | 1 | 17,583 | Bill Lee | Dennis Leonard | Bill Lee | Lindy McDaniel | Roger Moret | 282 | 271 | 11 |
| 1975-06-16 | @ DET | 57 | W 6-2 | 33-24 | 1 | 17,074 | Jim Burton | Mickey Lolich | Reggie Cleveland | Tom Walker | | 288 | 273 | 15 |
| 1975-06-17 | @ DET | 58 | W 7-6 | 34-24 | 1 | 9,803 | Rick Wise | Lerrin LaGrow | Rick Wise | Lerrin LaGrow | Dick Drago | 295 | 279 | 16 |
| 1975-06-18 | @ DET | 59 | W 15-1 | 35-24 | 1 | 13,029 | Luis Tiant | Joe Coleman | Luis Tiant | Joe Coleman | | 310 | 280 | 30 |
| 1975-06-20 | @ BAL | 60 | W 4-3 | 36-24 | 1 | 20,130 | Bill Lee | Mike Torrez | Dick Drago | Dyar Miller | | 314 | 283 | 31 |
| 1975-06-21 | @ BAL | 61 | L 0-3 | 36-25 | 1 | 12,210 | Dick Pole | Jim Palmer | Jim Palmer | Dick Pole | | 314 | 286 | 28 |
| 1975-06-22 | @ BAL | 62 | L 0-3 | 37-26 | 1 | 0 | Rick Wise | Mike Cuellar | Mike Cuellar | Rick Wise | | 314 | 289 | 25 |
| 1975-06-22 | @ BAL | 63 | W 5-1 | 37-26 | 1 | 29,242 | Luis Tiant | Doyle Alexander | Luis Tiant | Doyle Alexander | | 319 | 290 | 29 |
| 1975-06-23 | vs CLE | 64 | L 3-11 | 37-27 | 1 | 19,591 | Jim Burton | Eric Raich | Eric Raich | Jim Burton | | 322 | 301 | 21 |
| 1975-06-24 | vs CLE | 65 | L 6-8 | 37-28 | 2 | 15,411 | Bill Lee | Jim Kern | Tom Buskey | Dick Drago | | 328 | 309 | 19 |
| 1975-06-25 | vs CLE | 66 | L 5-8 | 37-29 | 2 | 20,847 | Dick Pole | Roric Harrison | Roric Harrison | Dick Pole | Tom Buskey | 333 | 317 | 16 |
| 1975-06-26 | vs NYA | 67 | W 6-1 | 38-29 | 2 | 34,293 | Luis Tiant | Pat Dobson | Luis Tiant | Pat Dobson | | 339 | 318 | 21 |
| 1975-06-27 | vs NYA | 68 | W 9-1 | 39-29 | 1 | 35,489 | Rick Wise | Larry Gura | Rick Wise | Larry Gura | | 348 | 319 | 29 |
| 1975-06-28 | vs NYA | 69 | L 6-8 | 39-30 | 2 | 32,631 | Bill Lee | Doc Medich | Dick Tidrow | Reggie Cleveland | | 354 | 327 | 27 |
| 1975-06-29 | vs NYA | 70 | W 3-2 | 40-30 | 1 | 33,752 | Roger Moret | Catfish Hunter | Roger Moret | Catfish Hunter | | 357 | 329 | 28 |
| 1975-06-30 | vs BAL | 71 | W 5-2 | 41-31 | 1 | 0 | Dick Pole | Jim Palmer | Dick Pole | Jim Palmer | Diego Segui | 362 | 331 | 31 |
| 1975-06-30 | vs BAL | 72 | L 2-8 | 41-31 | 1 | 32,817 | Luis Tiant | Doyle Alexander | Doyle Alexander | Luis Tiant | Grant Jackson | 364 | 339 | 25 |
| 1975-07-01 | vs BAL | 73 | L 6-10 | 41-32 | 1 | 22,239 | Dick Drago | Paul Mitchell | Grant Jackson | Reggie Cleveland | | 370 | 349 | 21 |
| 1975-07-02 | @ MIL | 74 | W 6-3 | 42-33 | 1 | 0 | Rick Wise | Bill Castro | Rick Wise | Bill Castro | | 376 | 352 | 24 |
| 1975-07-02 | @ MIL | 75 | L 3-4 | 42-33 | 1 | 34,455 | Bill Lee | Tom Hausman | Pete Broberg | Bill Lee | | 379 | 356 | 23 |
| 1975-07-03 | @ MIL | 76 | L 2-3 | 42-34 | 1 | 16,225 | Roger Moret | Jim Slaton | Rick Austin | Diego Segui | | 381 | 359 | 22 |
| 1975-07-04 | @ CLE | 77 | L 2-3 | 42-35 | 1 | 36,124 | Luis Tiant | Eric Raich | Eric Raich | Luis Tiant | Dave LaRoche | 383 | 362 | 21 |
| 1975-07-05 | @ CLE | 78 | L 2-12 | 42-36 | 1 | 22,361 | Steve Barr | Roric Harrison | Roric Harrison | Steve Barr | | 385 | 374 | 11 |
| 1975-07-06 | @ CLE | 79 | W 5-3 | 43-37 | 1 | 0 | Bill Lee | Jim Bibby | Bill Lee | Jim Bibby | Dick Drago | 390 | 377 | 13 |
| 1975-07-06 | @ CLE | 80 | L 10-11 | 43-37 | 1 | 59,161 | Reggie Cleveland | Jackie Brown | Fred Beene | Reggie Cleveland | Dave LaRoche | 400 | 388 | 12 |
| 1975-07-07 | vs MIN | 81 | W 6-3 | 44-37 | 1 | 21,885 | Rick Wise | Jim Hughes | Rick Wise | Jim Hughes | Jim Willoughby | 406 | 391 | 15 |
| 1975-07-08 | vs MIN | 82 | W 6-5 | 45-37 | 1 | 17,519 | Luis Tiant | Bill Campbell | Reggie Cleveland | Tom Johnson | | 412 | 396 | 16 |
| 1975-07-09 | vs MIN | 83 | W 9-8 | 46-37 | 1 | 21,103 | Roger Moret | Dave Goltz | Diego Segui | Tom Burgmeier | | 421 | 404 | 17 |
| 1975-07-10 | vs TEX | 84 | W 8-7 | 47-37 | 1 | 17,365 | Steve Barr | Gaylord Perry | Reggie Cleveland | Gaylord Perry | | 429 | 411 | 18 |
| 1975-07-11 | vs TEX | 85 | W 11-8 | 48-37 | 1 | 27,178 | Dick Drago | Bill Hands | Jim Burton | Stan Thomas | Diego Segui | 440 | 419 | 21 |
| 1975-07-12 | vs TEX | 86 | W 10-4 | 49-37 | 1 | 20,694 | Luis Tiant | Fergie Jenkins | Luis Tiant | Fergie Jenkins | | 450 | 423 | 27 |
| 1975-07-13 | vs TEX | 87 | W 7-5 | 50-37 | 1 | 26,170 | Rick Wise | Steve Hargan | Rick Wise | Steve Hargan | Jim Willoughby | 457 | 428 | 29 |
| 1975-07-17 | vs KCA | 88 | W 8-3 | 51-37 | 1 | 28,794 | Luis Tiant | Al Fitzmorris | Luis Tiant | Al Fitzmorris | | 465 | 431 | 34 |
| 1975-07-18 | vs KCA | 89 | W 9-3 | 52-37 | 1 | 30,226 | Bill Lee | Steve Busby | Bill Lee | Steve Busby | | 474 | 434 | 40 |
| 1975-07-19 | @ TEX | 90 | W 8-0 | 53-37 | 1 | 30,076 | Rick Wise | Bill Hands | Rick Wise | Bill Hands | | 482 | 434 | 48 |
| 1975-07-20 | @ TEX | 91 | L 5-10 | 54-38 | 1 | 0 | Roger Moret | Clyde Wright | Clyde Wright | Roger Moret | Jim Umbarger | 487 | 444 | 43 |
| 1975-07-20 | @ TEX | 92 | W 3-2 | 54-38 | 1 | 13,775 | Reggie Cleveland | Steve Hargan | Reggie Cleveland | Steve Hargan | Jim Willoughby | 490 | 446 | 44 |
| 1975-07-21 | @ TEX | 93 | L 0-6 | 54-39 | 1 | 11,147 | Luis Tiant | Fergie Jenkins | Fergie Jenkins | Luis Tiant | | 490 | 452 | 38 |
| 1975-07-22 | @ MIN | 94 | W 5-4 | 55-39 | 1 | 9,531 | Bill Lee | Dave Goltz | Bill Lee | Dave Goltz | | 495 | 456 | 39 |
| 1975-07-23 | @ MIN | 95 | W 4-2 | 56-39 | 1 | 9,452 | Roger Moret | Jim Hughes | Roger Moret | Jim Hughes | Jim Willoughby | 499 | 458 | 41 |
| 1975-07-24 | @ MIN | 96 | W 6-2 | 57-39 | 1 | 14,880 | Rick Wise | Joe Decker | Rick Wise | Joe Decker | | 505 | 460 | 45 |
| 1975-07-25 | @ NYA | 97 | L 6-8 | 57-40 | 1 | 40,165 | Luis Tiant | Rudy May | Rudy May | Luis Tiant | Tippy Martinez | 511 | 468 | 43 |
| 1975-07-26 | @ NYA | 98 | W 4-2 | 58-40 | 1 | 37,387 | Reggie Cleveland | Pat Dobson | Reggie Cleveland | Pat Dobson | Jim Willoughby | 515 | 470 | 45 |
| 1975-07-27 | @ NYA | 99 | W 1-0 | 60-40 | 1 | 0 | Bill Lee | Catfish Hunter | Bill Lee | Catfish Hunter | | 516 | 470 | 46 |
| 1975-07-27 | @ NYA | 100 | W 6-0 | 60-40 | 1 | 53,631 | Roger Moret | Tippy Martinez | Roger Moret | Tippy Martinez | | 522 | 470 | 52 |
| 1975-07-28 | vs MIL | 101 | W 7-6 | 61-40 | 1 | 33,606 | Rick Wise | Pete Broberg | Jim Willoughby | Tom Murphy | | 529 | 476 | 53 |
| 1975-07-29 | vs MIL | 102 | L 0-4 | 61-41 | 1 | 33,506 | Diego Segui | Jim Colborn | Jim Colborn | Diego Segui | | 529 | 480 | 49 |
| 1975-07-30 | vs MIL | 103 | L 2-6 | 61-42 | 1 | 33,763 | Reggie Cleveland | Jim Slaton | Jim Slaton | Reggie Cleveland | | 531 | 486 | 45 |
| 1975-07-31 | vs DET | 104 | W 3-2 | 63-42 | 1 | 0 | Bill Lee | Ray Bare | Bill Lee | Bob Reynolds | | 534 | 488 | 46 |
| 1975-07-31 | vs DET | 105 | W 6-1 | 63-42 | 1 | 31,317 | Roger Moret | Dave Lemanczyk | Roger Moret | Dave Lemanczyk | | 540 | 489 | 51 |
| 1975-08-01 | vs DET | 106 | W 8-7 | 64-42 | 1 | 26,537 | Luis Tiant | Lerrin LaGrow | Jim Willoughby | Gene Pentz | | 548 | 496 | 52 |
| 1975-08-02 | vs DET | 107 | W 7-2 | 65-42 | 1 | 27,188 | Rick Wise | Vern Ruhle | Rick Wise | Vern Ruhle | | 555 | 498 | 57 |
| 1975-08-03 | vs DET | 108 | W 6-4 | 66-42 | 1 | 23,575 | Reggie Cleveland | Joe Coleman | Reggie Cleveland | Tom Walker | Jim Willoughby | 561 | 502 | 59 |
| 1975-08-04 | vs BAL | 109 | L 8-12 | 66-43 | 1 | 35,866 | Bill Lee | Paul Mitchell | Doyle Alexander | Jim Willoughby | Dyar Miller | 569 | 514 | 55 |
| 1975-08-05 | vs BAL | 110 | L 0-3 | 66-44 | 1 | 35,662 | Luis Tiant | Jim Palmer | Jim Palmer | Luis Tiant | | 569 | 517 | 52 |
| 1975-08-06 | @ MIL | 111 | W 5-2 | 67-44 | 1 | 16,556 | Jim Burton | Jim Colborn | Jim Willoughby | Tom Murphy | | 574 | 519 | 55 |
| 1975-08-07 | @ MIL | 112 | W 4-2 | 68-44 | 1 | 24,817 | Rick Wise | Jim Slaton | Rick Wise | Jim Slaton | | 578 | 521 | 57 |
| 1975-08-08 | @ OAK | 113 | L 2-3 | 68-45 | 1 | 20,575 | Reggie Cleveland | Ken Holtzman | Ken Holtzman | Reggie Cleveland | Rollie Fingers | 580 | 524 | 56 |
| 1975-08-09 | @ OAK | 114 | W 7-2 | 69-45 | 1 | 16,828 | Bill Lee | Sonny Siebert | Bill Lee | Sonny Siebert | | 587 | 526 | 61 |
| 1975-08-10 | @ OAK | 115 | W 5-3 | 70-45 | 1 | 18,806 | Luis Tiant | Dick Bosman | Luis Tiant | Dick Bosman | Jim Willoughby | 592 | 529 | 63 |
| 1975-08-11 | @ OAK | 116 | L 3-4 | 70-46 | 1 | 46,376 | Roger Moret | Vida Blue | Vida Blue | Roger Moret | Jim Todd | 595 | 533 | 62 |
| 1975-08-12 | @ CAL | 117 | W 8-2 | 71-46 | 1 | 12,365 | Rick Wise | Chuck Hockenbery | Rick Wise | Chuck Hockenbery | | 603 | 535 | 68 |
| 1975-08-13 | @ CAL | 118 | L 3-8 | 71-47 | 1 | 13,750 | Reggie Cleveland | Ed Figueroa | Ed Figueroa | Reggie Cleveland | | 606 | 543 | 63 |
| 1975-08-14 | @ CAL | 119 | L 3-5 | 71-48 | 1 | 11,984 | Bill Lee | Bill Singer | Bill Singer | Bill Lee | Don Kirkwood | 609 | 548 | 61 |
| 1975-08-15 | @ CHA | 120 | W 3-2 | 72-48 | 1 | 17,281 | Luis Tiant | Jesse Jefferson | Luis Tiant | Jesse Jefferson | | 612 | 550 | 62 |
| 1975-08-16 | @ CHA | 121 | W 5-0 | 73-48 | 1 | 15,352 | Roger Moret | Wilbur Wood | Roger Moret | Wilbur Wood | Jim Willoughby | 617 | 550 | 67 |
| 1975-08-17 | @ CHA | 122 | L 2-6 | 74-49 | 1 | 0 | Rick Wise | Terry Forster | Dave Hamilton | Rick Wise | Rich Gossage | 619 | 556 | 63 |
| 1975-08-17 | @ CHA | 123 | W 4-3 | 74-49 | 1 | 21,995 | Reggie Cleveland | Jim Kaat | Jim Willoughby | Rich Gossage | | 623 | 559 | 64 |
| 1975-08-19 | @ KCA | 124 | W 5-0 | 75-49 | 1 | 19,505 | Bill Lee | Al Fitzmorris | Bill Lee | Al Fitzmorris | | 628 | 559 | 69 |
| 1975-08-20 | @ KCA | 125 | L 1-3 | 75-50 | 1 | 18,037 | Luis Tiant | Dennis Leonard | Dennis Leonard | Luis Tiant | | 629 | 562 | 67 |
| 1975-08-22 | vs CHA | 126 | W 2-1 | 76-50 | 1 | 32,458 | Roger Moret | Claude Osteen | Roger Moret | Claude Osteen | | 631 | 563 | 68 |
| 1975-08-23 | vs CHA | 127 | L 4-6 | 76-51 | 1 | 27,730 | Rick Wise | Jesse Jefferson | Jesse Jefferson | Rick Wise | Rich Gossage | 635 | 569 | 66 |
| 1975-08-24 | vs CHA | 128 | W 6-1 | 77-51 | 1 | 22,024 | Bill Lee | Wilbur Wood | Bill Lee | Wilbur Wood | | 641 | 570 | 71 |
| 1975-08-26 | vs CAL | 129 | L 2-8 | 77-52 | 1 | 32,086 | Luis Tiant | Ed Figueroa | Ed Figueroa | Luis Tiant | | 643 | 578 | 65 |
| 1975-08-27 | vs CAL | 130 | W 6-2 | 78-52 | 1 | 34,227 | Roger Moret | Bill Singer | Roger Moret | Bill Singer | Dick Drago | 649 | 580 | 69 |
| 1975-08-29 | vs OAK | 131 | W 6-1 | 79-52 | 1 | 34,341 | Rick Wise | Stan Bahnsen | Rick Wise | Stan Bahnsen | | 655 | 581 | 74 |
| 1975-08-30 | vs OAK | 132 | L 6-7 | 79-53 | 1 | 28,171 | Luis Tiant | Glenn Abbott | Rollie Fingers | Dick Drago | | 661 | 588 | 73 |
| 1975-08-31 | vs OAK | 133 | L 6-8 | 79-54 | 1 | 32,753 | Bill Lee | Sonny Siebert | Rollie Fingers | Diego Segui | | 667 | 596 | 71 |
| 1975-09-01 | vs NYA | 134 | L 2-4 | 79-55 | 1 | 30,218 | Roger Moret | Doc Medich | Doc Medich | Roger Moret | Tippy Martinez | 669 | 600 | 69 |
| 1975-09-02 | vs NYA | 135 | W 7-4 | 80-55 | 1 | 28,598 | Reggie Cleveland | Pat Dobson | Reggie Cleveland | Pat Dobson | Dick Drago | 676 | 604 | 72 |
| 1975-09-03 | @ BAL | 136 | W 3-2 | 81-55 | 1 | 30,968 | Rick Wise | Jim Palmer | Rick Wise | Jim Palmer | | 679 | 606 | 73 |
| 1975-09-04 | @ BAL | 137 | W 3-1 | 82-55 | 1 | 25,334 | Dick Pole | Mike Torrez | Dick Pole | Mike Torrez | Dick Drago | 682 | 607 | 75 |
| 1975-09-05 | @ MIL | 138 | L 2-4 | 82-56 | 1 | 11,864 | Bill Lee | Pete Broberg | Pete Broberg | Bill Lee | | 684 | 611 | 73 |
| 1975-09-06 | @ MIL | 139 | W 20-6 | 83-56 | 1 | 11,992 | Roger Moret | Bill Travers | Roger Moret | Bill Travers | | 704 | 617 | 87 |
| 1975-09-07 | @ MIL | 140 | W 6-3 | 84-57 | 1 | 0 | Reggie Cleveland | Jim Colborn | Reggie Cleveland | Jim Colborn | Dick Drago | 710 | 620 | 90 |
| 1975-09-07 | @ MIL | 141 | L 3-7 | 84-57 | 1 | 11,904 | Dick Pole | Bill Travers | Bill Travers | Dick Pole | | 713 | 627 | 86 |
| 1975-09-08 | @ CLE | 142 | L 1-4 | 84-58 | 1 | 7,438 | Rick Wise | Don Hood | Don Hood | Rick Wise | | 714 | 631 | 83 |
| 1975-09-09 | @ CLE | 143 | L 2-3 | 84-59 | 1 | 7,762 | Bill Lee | Rick Waits | Rick Waits | Bill Lee | | 716 | 634 | 82 |
| 1975-09-10 | vs DET | 144 | W 7-4 | 85-60 | 1 | 0 | Roger Moret | Vern Ruhle | Roger Moret | Vern Ruhle | Dick Drago | 723 | 638 | 85 |
| 1975-09-10 | vs DET | 145 | L 3-5 | 85-60 | 1 | 20,189 | Dick Pole | Fernando Arroyo | Fernando Arroyo | Jim Willoughby | | 726 | 643 | 83 |
| 1975-09-11 | vs DET | 146 | W 3-1 | 86-60 | 1 | 9,508 | Luis Tiant | Dave Lemanczyk | Luis Tiant | Dave Lemanczyk | | 729 | 644 | 85 |
| 1975-09-13 | vs MIL | 147 | L 6-9 | 87-61 | 1 | 28,515 | Rick Wise | Pete Broberg | Pete Broberg | Rick Wise | Tom Murphy | 735 | 653 | 82 |
| 1975-09-13 | vs MIL | 148 | W 6-3 | 87-61 | 1 | 20,974 | Reggie Cleveland | Bill Travers | Reggie Cleveland | Bill Travers | Jim Burton | 741 | 656 | 85 |
| 1975-09-14 | vs MIL | 149 | W 8-6 | 88-61 | 1 | 28,187 | Bill Lee | Jim Slaton | Jim Willoughby | Tom Murphy | Dick Drago | 749 | 662 | 87 |
| 1975-09-15 | vs MIL | 150 | W 9-7 | 89-61 | 1 | 16,302 | Roger Moret | Jim Colborn | Roger Moret | Jim Colborn | | 758 | 669 | 89 |
| 1975-09-16 | vs BAL | 151 | W 2-0 | 90-61 | 1 | 34,724 | Luis Tiant | Jim Palmer | Luis Tiant | Jim Palmer | | 760 | 669 | 91 |
| 1975-09-17 | vs BAL | 152 | L 2-5 | 90-62 | 1 | 31,806 | Rick Wise | Mike Torrez | Mike Torrez | Rick Wise | Dyar Miller | 762 | 674 | 88 |
| 1975-09-19 | @ DET | 153 | W 7-5 | 91-62 | 1 | 7,780 | Bill Lee | Ray Bare | Dick Pole | Ed Glynn | Dick Drago | 769 | 679 | 90 |
| 1975-09-20 | @ DET | 154 | L 1-5 | 91-63 | 1 | 10,186 | Luis Tiant | Mickey Lolich | Mickey Lolich | Luis Tiant | | 770 | 684 | 86 |
| 1975-09-21 | @ DET | 155 | W 6-5 | 92-63 | 1 | 9,059 | Roger Moret | Vern Ruhle | Dick Drago | Gene Pentz | | 776 | 689 | 87 |
| 1975-09-22 | @ NYA | 156 | W 6-4 | 93-63 | 1 | 10,622 | Rick Wise | Ron Guidry | Rick Wise | Ron Guidry | Dick Drago | 782 | 693 | 89 |
| 1975-09-26 | vs CLE | 157 | W 4-0 | 95-63 | 1 | 0 | Luis Tiant | Dennis Eckersley | Luis Tiant | Dennis Eckersley | | 786 | 693 | 93 |
| 1975-09-26 | vs CLE | 158 | W 4-0 | 95-63 | 1 | 22,067 | Reggie Cleveland | Don Hood | Reggie Cleveland | Don Hood | | 790 | 693 | 97 |
| 1975-09-27 | vs CLE | 159 | L 2-5 | 95-64 | 1 | 22,072 | Rick Wise | Rick Waits | Rick Waits | Rick Wise | | 792 | 698 | 94 |
| 1975-09-28 | vs CLE | 160 | L 4-11 | 95-65 | 1 | 25,991 | Dick Pole | Fred Beene | Eric Raich | Dick Pole | Jim Strickland | 796 | 709 | 87 |