| 1975-04-08 | vs MIN | 1 | L 4-11 | 0-1 | 6 | 28,787 | Fergie Jenkins | Bert Blyleven | Bert Blyleven | Fergie Jenkins | Bill Campbell | 4 | 11 | -7 |
| 1975-04-09 | vs MIN | 2 | L 2-3 | 0-2 | 6 | 6,149 | Jim Bibby | Joe Decker | Joe Decker | Jim Bibby | Tom Burgmeier | 6 | 14 | -8 |
| 1975-04-10 | vs MIN | 3 | W 5-4 | 1-2 | 6 | 5,066 | Jackie Brown | Dave Goltz | Steve Foucault | Dave Goltz | | 11 | 18 | -7 |
| 1975-04-11 | vs OAK | 4 | L 5-7 | 1-3 | 6 | 14,979 | Bill Hands | Glenn Abbott | Paul Lindblad | Bill Hands | | 16 | 25 | -9 |
| 1975-04-12 | vs OAK | 5 | L 4-5 | 1-4 | 6 | 20,598 | Fergie Jenkins | Vida Blue | Vida Blue | Fergie Jenkins | Rollie Fingers | 20 | 30 | -10 |
| 1975-04-15 | @ CHA | 6 | W 6-5 | 2-4 | 5 | 20,202 | Clyde Wright | Claude Osteen | Steve Hargan | Rich Gossage | | 26 | 35 | -9 |
| 1975-04-16 | @ CHA | 7 | W 14-4 | 3-4 | 4 | 2,159 | Jim Bibby | Wilbur Wood | Jim Umbarger | Wilbur Wood | | 40 | 39 | 1 |
| 1975-04-17 | @ CHA | 8 | W 7-3 | 4-4 | 3 | 1,295 | Fergie Jenkins | Stan Bahnsen | Fergie Jenkins | Stan Bahnsen | | 47 | 42 | 5 |
| 1975-04-18 | vs KCA | 9 | L 3-5 | 4-5 | 5 | 23,080 | Jackie Brown | Steve Busby | Steve Busby | Jackie Brown | | 50 | 47 | 3 |
| 1975-04-19 | vs KCA | 10 | L 2-5 | 4-6 | 5 | 18,363 | Bill Hands | Paul Splittorff | Paul Splittorff | Bill Hands | Doug Bird | 52 | 52 | 0 |
| 1975-04-20 | vs KCA | 11 | L 0-2 | 4-7 | 4 | 13,412 | Steve Hargan | Al Fitzmorris | Al Fitzmorris | Steve Hargan | | 52 | 54 | -2 |
| 1975-04-21 | @ OAK | 12 | L 6-11 | 4-8 | 5 | 25,865 | Jim Bibby | Blue Moon Odom | Paul Lindblad | Jim Bibby | | 58 | 65 | -7 |
| 1975-04-22 | @ OAK | 13 | W 2-1 | 5-8 | 5 | 2,607 | Fergie Jenkins | Ken Holtzman | Fergie Jenkins | Ken Holtzman | | 60 | 66 | -6 |
| 1975-04-23 | @ CAL | 14 | L 1-4 | 5-9 | 5 | 8,391 | Clyde Wright | Bill Singer | Bill Singer | Clyde Wright | | 61 | 70 | -9 |
| 1975-04-24 | @ CAL | 15 | W 5-0 | 6-9 | 5 | 10,002 | Jackie Brown | Nolan Ryan | Jackie Brown | Nolan Ryan | | 66 | 70 | -4 |
| 1975-04-26 | @ MIN | 16 | W 7-2 | 7-9 | 4 | 4,698 | Bill Hands | Vic Albury | Bill Hands | Vic Albury | Steve Foucault | 73 | 72 | 1 |
| 1975-04-29 | vs CHA | 17 | W 3-2 | 8-9 | 4 | 7,107 | Fergie Jenkins | Claude Osteen | Fergie Jenkins | Claude Osteen | | 76 | 74 | 2 |
| 1975-04-30 | vs CHA | 18 | W 8-2 | 9-9 | 4 | 8,105 | Jim Bibby | Stan Bahnsen | Jim Bibby | Stan Bahnsen | | 84 | 76 | 8 |
| 1975-05-01 | vs CHA | 19 | W 2-1 | 10-9 | 4 | 6,481 | Clyde Wright | Jim Kaat | Steve Foucault | Rich Gossage | | 86 | 77 | 9 |
| 1975-05-02 | vs CAL | 20 | W 4-3 | 11-9 | 2 | 10,513 | Steve Hargan | Bill Singer | Steve Hargan | Bill Singer | | 90 | 80 | 10 |
| 1975-05-03 | vs CAL | 21 | L 2-4 | 11-10 | 3 | 37,625 | Jackie Brown | Nolan Ryan | Nolan Ryan | Jackie Brown | Dick Lange | 92 | 84 | 8 |
| 1975-05-04 | vs CAL | 22 | W 1-0 | 12-10 | 2 | 10,435 | Bill Hands | Andy Hassler | Bill Hands | Andy Hassler | Steve Foucault | 93 | 84 | 9 |
| 1975-05-05 | vs CAL | 23 | W 4-3 | 13-10 | 2 | 10,300 | Fergie Jenkins | Frank Tanana | Fergie Jenkins | Dick Lange | | 97 | 87 | 10 |
| 1975-05-06 | @ KCA | 24 | L 2-6 | 13-11 | 2 | 7,535 | Jim Bibby | Nelson Briles | Nelson Briles | Jim Bibby | | 99 | 93 | 6 |
| 1975-05-07 | @ KCA | 25 | L 5-6 | 13-12 | 3 | 7,282 | Clyde Wright | Steve Busby | Steve Busby | Clyde Wright | Doug Bird | 104 | 99 | 5 |
| 1975-05-08 | @ KCA | 26 | W 5-3 | 14-12 | 2 | 8,403 | Steve Hargan | Dennis Leonard | Steve Hargan | Doug Bird | | 109 | 102 | 7 |
| 1975-05-09 | @ DET | 27 | W 3-1 | 15-12 | 2 | 23,370 | Jackie Brown | Lerrin LaGrow | Jackie Brown | Lerrin LaGrow | | 112 | 103 | 9 |
| 1975-05-10 | @ DET | 28 | W 5-2 | 16-12 | 2 | 15,283 | Bill Hands | Joe Coleman | Bill Hands | Joe Coleman | | 117 | 105 | 12 |
| 1975-05-11 | @ DET | 29 | W 11-7 | 17-12 | 2 | 11,854 | Fergie Jenkins | Mickey Lolich | Fergie Jenkins | Mickey Lolich | Steve Foucault | 128 | 112 | 16 |
| 1975-05-13 | vs MIL | 30 | W 5-0 | 18-12 | 2 | 18,696 | Jim Bibby | Jim Slaton | Jim Bibby | Jim Slaton | | 133 | 112 | 21 |
| 1975-05-14 | vs MIL | 31 | L 2-3 | 18-13 | 2 | 12,090 | Clyde Wright | Ed Sprague | Eduardo Rodriguez | Jackie Brown | Jim Colborn | 135 | 115 | 20 |
| 1975-05-15 | vs MIL | 32 | L 5-8 | 18-14 | 2 | 22,823 | Steve Hargan | Pete Broberg | Pete Broberg | Steve Hargan | Eduardo Rodriguez | 140 | 123 | 17 |
| 1975-05-16 | vs DET | 33 | W 10-3 | 19-14 | 2 | 15,755 | Bill Hands | Mickey Lolich | Bill Hands | Mickey Lolich | | 150 | 126 | 24 |
| 1975-05-17 | vs DET | 34 | L 4-6 | 19-15 | 2 | 21,896 | Jackie Brown | Vern Ruhle | Vern Ruhle | Jackie Brown | John Hiller | 154 | 132 | 22 |
| 1975-05-18 | vs DET | 35 | W 7-6 | 20-15 | 2 | 12,682 | Fergie Jenkins | Lerrin LaGrow | Stan Thomas | Dave Lemanczyk | | 161 | 138 | 23 |
| 1975-05-20 | @ MIL | 36 | L 6-7 | 20-16 | 2 | 13,971 | Jim Bibby | Pete Broberg | Eduardo Rodriguez | Jackie Brown | | 167 | 145 | 22 |
| 1975-05-21 | @ MIL | 37 | W 5-4 | 21-16 | 2 | 12,196 | Steve Hargan | Bill Champion | Steve Hargan | Bill Champion | Steve Foucault | 172 | 149 | 23 |
| 1975-05-22 | @ MIL | 38 | W 6-0 | 22-16 | 1 | 17,808 | Bill Hands | Jim Colborn | Bill Hands | Jim Colborn | | 178 | 149 | 29 |
| 1975-05-23 | @ NYA | 39 | L 7-11 | 22-17 | 2 | 19,210 | Fergie Jenkins | Catfish Hunter | Catfish Hunter | Fergie Jenkins | | 185 | 160 | 25 |
| 1975-05-24 | @ NYA | 40 | L 5-9 | 22-18 | 2 | 15,659 | Clyde Wright | Rudy May | Dick Tidrow | Clyde Wright | Sparky Lyle | 190 | 169 | 21 |
| 1975-05-25 | @ NYA | 41 | L 4-5 | 22-19 | 4 | 23,084 | Jim Bibby | Pat Dobson | Pat Dobson | Jim Bibby | Sparky Lyle | 194 | 174 | 20 |
| 1975-05-26 | vs BOS | 42 | L 5-7 | 22-20 | 4 | 15,478 | Steve Hargan | Rick Wise | Rick Wise | Steve Foucault | Dick Drago | 199 | 181 | 18 |
| 1975-05-28 | vs BOS | 43 | L 1-4 | 22-21 | 4 | 8,091 | Fergie Jenkins | Bill Lee | Bill Lee | Fergie Jenkins | | 200 | 185 | 15 |
| 1975-05-29 | vs NYA | 44 | L 5-7 | 22-22 | 4 | 12,827 | Clyde Wright | Pat Dobson | Dick Tidrow | Jim Umbarger | | 205 | 192 | 13 |
| 1975-05-30 | vs NYA | 45 | W 6-5 | 23-22 | 4 | 16,887 | Jim Bibby | Doc Medich | Jackie Brown | Sparky Lyle | | 211 | 197 | 14 |
| 1975-05-31 | vs NYA | 46 | L 0-6 | 23-23 | 4 | 38,714 | Bill Hands | Catfish Hunter | Catfish Hunter | Bill Hands | | 211 | 203 | 8 |
| 1975-06-01 | vs NYA | 47 | L 4-8 | 23-24 | 4 | 15,866 | Fergie Jenkins | Rudy May | Rudy May | Fergie Jenkins | | 215 | 211 | 4 |
| 1975-06-03 | @ BAL | 48 | L 3-6 | 23-25 | 4 | 12,100 | Steve Hargan | Mike Torrez | Mike Torrez | Steve Hargan | | 218 | 217 | 1 |
| 1975-06-04 | @ BAL | 49 | W 3-2 | 24-25 | 4 | 6,428 | Jim Bibby | Jim Palmer | Jackie Brown | Grant Jackson | | 221 | 219 | 2 |
| 1975-06-06 | @ CLE | 50 | L 5-7 | 24-26 | 5 | 12,308 | Fergie Jenkins | Dennis Eckersley | Dave LaRoche | Fergie Jenkins | | 226 | 226 | 0 |
| 1975-06-07 | @ CLE | 51 | W 5-4 | 25-26 | 4 | 18,800 | Steve Hargan | Gaylord Perry | Stan Thomas | Gaylord Perry | | 231 | 230 | 1 |
| 1975-06-08 | @ CLE | 52 | L 2-3 | 26-27 | 4 | 0 | Jim Bibby | Eric Raich | Eric Raich | Jim Bibby | Dave LaRoche | 233 | 233 | 0 |
| 1975-06-08 | @ CLE | 53 | W 7-6 | 26-27 | 4 | 15,146 | Jackie Brown | Fritz Peterson | Stan Thomas | Tom Buskey | | 240 | 239 | 1 |
| 1975-06-09 | @ BOS | 54 | W 12-4 | 27-27 | 4 | 13,597 | Bill Hands | Rick Wise | Jackie Brown | Rick Wise | | 252 | 243 | 9 |
| 1975-06-10 | @ BOS | 55 | W 8-3 | 28-27 | 4 | 20,919 | Fergie Jenkins | Luis Tiant | Fergie Jenkins | Luis Tiant | | 260 | 246 | 14 |
| 1975-06-11 | vs BAL | 56 | L 8-9 | 28-28 | 4 | 13,488 | Steve Hargan | Mike Torrez | Dyar Miller | Stan Thomas | | 268 | 255 | 13 |
| 1975-06-12 | vs BAL | 57 | L 1-7 | 28-29 | 5 | 13,865 | Jim Bibby | Jim Palmer | Jim Palmer | Jim Bibby | | 269 | 262 | 7 |
| 1975-06-13 | vs CLE | 58 | W 2-1 | 29-29 | 4 | 24,347 | Jim Umbarger | Fritz Peterson | Jim Umbarger | Fritz Peterson | Mike Kekich | 271 | 263 | 8 |
| 1975-06-14 | vs CLE | 59 | W 2-1 | 30-29 | 3 | 22,789 | Fergie Jenkins | Roric Harrison | Fergie Jenkins | Roric Harrison | | 273 | 264 | 9 |
| 1975-06-15 | vs CLE | 60 | L 1-5 | 30-30 | 4 | 27,171 | Gaylord Perry | Dennis Eckersley | Dennis Eckersley | Gaylord Perry | | 274 | 269 | 5 |
| 1975-06-17 | vs CHA | 61 | L 3-13 | 30-31 | 4 | 11,973 | Jim Umbarger | Jim Kaat | Jim Kaat | Jim Umbarger | Rich Gossage | 277 | 282 | -5 |
| 1975-06-18 | vs CHA | 62 | W 10-3 | 31-31 | 3 | 11,076 | Fergie Jenkins | Wilbur Wood | Fergie Jenkins | Wilbur Wood | | 287 | 285 | 2 |
| 1975-06-19 | vs CHA | 63 | W 5-3 | 32-31 | 3 | 11,709 | Steve Hargan | Claude Osteen | Stan Thomas | Rich Gossage | | 292 | 288 | 4 |
| 1975-06-20 | @ CAL | 64 | L 11-12 | 32-32 | 3 | 12,101 | Gaylord Perry | Bill Singer | Don Kirkwood | Steve Foucault | | 303 | 300 | 3 |
| 1975-06-21 | @ CAL | 65 | L 2-4 | 33-33 | 4 | 0 | Jim Umbarger | Frank Tanana | Frank Tanana | Jim Umbarger | | 305 | 304 | 1 |
| 1975-06-21 | @ CAL | 66 | W 6-5 | 33-33 | 4 | 19,424 | Clyde Wright | Andy Hassler | Jim Umbarger | Luis Quintana | | 311 | 309 | 2 |
| 1975-06-22 | @ CAL | 67 | L 0-1 | 33-34 | 3 | 8,958 | Fergie Jenkins | Ed Figueroa | Ed Figueroa | Fergie Jenkins | | 311 | 310 | 1 |
| 1975-06-23 | @ CAL | 68 | W 1-0 | 34-34 | 3 | 27,182 | Steve Hargan | Bill Singer | Jim Umbarger | Don Kirkwood | | 312 | 310 | 2 |
| 1975-06-24 | @ CHA | 69 | L 5-7 | 34-35 | 3 | 6,318 | Gaylord Perry | Claude Osteen | Claude Osteen | Gaylord Perry | Rich Gossage | 317 | 317 | 0 |
| 1975-06-25 | @ CHA | 70 | L 2-5 | 34-36 | 3 | 6,590 | Mike Bacsik | Jim Kaat | Jim Kaat | Mike Bacsik | Dave Hamilton | 319 | 322 | -3 |
| 1975-06-26 | @ CHA | 71 | L 3-8 | 34-37 | 3 | 7,681 | Fergie Jenkins | Wilbur Wood | Wilbur Wood | Fergie Jenkins | Rich Gossage | 322 | 330 | -8 |
| 1975-06-27 | vs MIN | 72 | W 2-0 | 35-38 | 3 | 0 | Steve Hargan | Bert Blyleven | Steve Hargan | Bert Blyleven | | 324 | 330 | -6 |
| 1975-06-27 | vs MIN | 73 | L 5-8 | 35-38 | 3 | 20,601 | Bill Hands | Dave Goltz | Vic Albury | Jim Umbarger | | 329 | 338 | -9 |
| 1975-06-28 | vs MIN | 74 | L 3-5 | 35-39 | 3 | 18,191 | Gaylord Perry | Jim Hughes | Jim Hughes | Gaylord Perry | | 332 | 343 | -11 |
| 1975-06-29 | vs MIN | 75 | W 9-7 | 36-39 | 3 | 9,052 | Mike Bacsik | Bill Campbell | Mike Bacsik | Bill Campbell | Mike Kekich | 341 | 350 | -9 |
| 1975-07-01 | vs KCA | 76 | W 5-4 | 37-39 | 3 | 12,714 | Fergie Jenkins | Steve Busby | Fergie Jenkins | Steve Busby | Stan Thomas | 346 | 354 | -8 |
| 1975-07-02 | vs KCA | 77 | L 5-7 | 37-40 | 3 | 11,563 | Gaylord Perry | Marty Pattin | Doug Bird | Gaylord Perry | | 351 | 361 | -10 |
| 1975-07-03 | vs KCA | 78 | L 5-10 | 37-41 | 4 | 10,358 | Bill Hands | Al Fitzmorris | Al Fitzmorris | Bill Hands | | 356 | 371 | -15 |
| 1975-07-04 | @ MIN | 79 | L 0-8 | 38-42 | 4 | 0 | Mike Bacsik | Bill Campbell | Bill Campbell | Mike Bacsik | | 356 | 379 | -23 |
| 1975-07-04 | @ MIN | 80 | W 4-2 | 38-42 | 4 | 25,714 | Steve Hargan | Ray Corbin | Steve Hargan | Ray Corbin | | 360 | 381 | -21 |
| 1975-07-05 | @ MIN | 81 | L 4-5 | 38-43 | 4 | 9,399 | Fergie Jenkins | Dave Goltz | Dave Goltz | Fergie Jenkins | | 364 | 386 | -22 |
| 1975-07-06 | @ MIN | 82 | W 4-2 | 40-43 | 3 | 0 | Clyde Wright | Bert Blyleven | Clyde Wright | Bert Blyleven | Jim Umbarger | 368 | 388 | -20 |
| 1975-07-06 | @ MIN | 83 | W 7-0 | 40-43 | 3 | 14,211 | Gaylord Perry | Mark Wiley | Gaylord Perry | Mark Wiley | | 375 | 388 | -13 |
| 1975-07-07 | @ NYA | 84 | L 2-5 | 40-44 | 3 | 10,625 | Bill Hands | Doc Medich | Doc Medich | Bill Hands | | 377 | 393 | -16 |
| 1975-07-08 | @ NYA | 85 | L 0-4 | 40-45 | 3 | 16,020 | Steve Hargan | Catfish Hunter | Catfish Hunter | Steve Hargan | | 377 | 397 | -20 |
| 1975-07-09 | @ NYA | 86 | W 4-0 | 41-45 | 3 | 10,779 | Fergie Jenkins | Rudy May | Fergie Jenkins | Rudy May | | 381 | 397 | -16 |
| 1975-07-10 | @ BOS | 87 | L 7-8 | 41-46 | 3 | 17,365 | Gaylord Perry | Steve Barr | Reggie Cleveland | Gaylord Perry | | 388 | 405 | -17 |
| 1975-07-11 | @ BOS | 88 | L 8-11 | 41-47 | 4 | 27,178 | Bill Hands | Dick Drago | Jim Burton | Stan Thomas | Diego Segui | 396 | 416 | -20 |
| 1975-07-12 | @ BOS | 89 | L 4-10 | 41-48 | 4 | 20,694 | Fergie Jenkins | Luis Tiant | Luis Tiant | Fergie Jenkins | | 400 | 426 | -26 |
| 1975-07-13 | @ BOS | 90 | L 5-7 | 41-49 | 4 | 26,170 | Steve Hargan | Rick Wise | Rick Wise | Steve Hargan | Jim Willoughby | 405 | 433 | -28 |
| 1975-07-17 | vs NYA | 91 | W 7-2 | 42-49 | 4 | 18,025 | Fergie Jenkins | Pat Dobson | Fergie Jenkins | Pat Dobson | | 412 | 435 | -23 |
| 1975-07-18 | vs NYA | 92 | W 1-0 | 43-49 | 4 | 24,576 | Gaylord Perry | Catfish Hunter | Gaylord Perry | Catfish Hunter | | 413 | 435 | -22 |
| 1975-07-19 | vs BOS | 93 | L 0-8 | 43-50 | 4 | 30,076 | Bill Hands | Rick Wise | Rick Wise | Bill Hands | | 413 | 443 | -30 |
| 1975-07-20 | vs BOS | 94 | W 10-5 | 44-51 | 4 | 0 | Clyde Wright | Roger Moret | Clyde Wright | Roger Moret | Jim Umbarger | 423 | 448 | -25 |
| 1975-07-20 | vs BOS | 95 | L 2-3 | 44-51 | 4 | 13,775 | Steve Hargan | Reggie Cleveland | Reggie Cleveland | Steve Hargan | Jim Willoughby | 425 | 451 | -26 |
| 1975-07-21 | vs BOS | 96 | W 6-0 | 45-51 | 4 | 11,147 | Fergie Jenkins | Luis Tiant | Fergie Jenkins | Luis Tiant | | 431 | 451 | -20 |
| 1975-07-22 | vs CLE | 97 | W 4-0 | 46-51 | 4 | 10,106 | Gaylord Perry | Eric Raich | Gaylord Perry | Eric Raich | | 435 | 451 | -16 |
| 1975-07-23 | vs CLE | 98 | W 9-8 | 47-51 | 4 | 15,016 | Bill Hands | Roric Harrison | Steve Foucault | Jackie Brown | | 444 | 459 | -15 |
| 1975-07-25 | @ KCA | 99 | L 3-6 | 47-53 | 4 | 0 | Clyde Wright | Nelson Briles | Nelson Briles | Clyde Wright | Doug Bird | 447 | 465 | -18 |
| 1975-07-25 | @ KCA | 100 | L 1-6 | 47-53 | 4 | 23,889 | Stan Thomas | Dennis Leonard | Dennis Leonard | Stan Thomas | | 448 | 471 | -23 |
| 1975-07-26 | @ KCA | 101 | L 0-7 | 47-54 | 4 | 27,089 | Fergie Jenkins | Al Fitzmorris | Al Fitzmorris | Fergie Jenkins | | 448 | 478 | -30 |
| 1975-07-27 | @ KCA | 102 | L 1-2 | 47-55 | 4 | 12,103 | Gaylord Perry | Steve Busby | Steve Busby | Gaylord Perry | Doug Bird | 449 | 480 | -31 |
| 1975-07-28 | @ OAK | 103 | L 6-12 | 47-56 | 4 | 39,061 | Bill Hands | Glenn Abbott | Paul Lindblad | Tommy Moore | | 455 | 492 | -37 |
| 1975-07-29 | @ OAK | 104 | W 6-1 | 48-56 | 4 | 6,522 | Steve Hargan | Jim Perry | Steve Hargan | Jim Perry | | 461 | 493 | -32 |
| 1975-07-30 | @ OAK | 105 | L 0-1 | 48-57 | 4 | 6,631 | Fergie Jenkins | Ken Holtzman | Ken Holtzman | Fergie Jenkins | Paul Lindblad | 461 | 494 | -33 |
| 1975-08-01 | vs CAL | 106 | W 2-1 | 49-57 | 4 | 30,038 | Gaylord Perry | Ed Figueroa | Gaylord Perry | Ed Figueroa | | 463 | 495 | -32 |
| 1975-08-02 | vs CAL | 107 | W 8-2 | 50-57 | 4 | 13,013 | Bill Hands | Dick Lange | Bill Hands | Dick Lange | Stan Thomas | 471 | 497 | -26 |
| 1975-08-03 | vs CAL | 108 | L 4-6 | 50-58 | 4 | 9,745 | Steve Hargan | Nolan Ryan | Don Kirkwood | Tommy Moore | | 475 | 503 | -28 |
| 1975-08-04 | vs OAK | 109 | W 12-0 | 51-58 | 4 | 14,668 | Fergie Jenkins | Ken Holtzman | Fergie Jenkins | Ken Holtzman | | 487 | 503 | -16 |
| 1975-08-05 | vs OAK | 110 | L 2-3 | 52-59 | 4 | 0 | Stan Perzanowski | Dick Bosman | Dick Bosman | Stan Perzanowski | Rollie Fingers | 489 | 506 | -17 |
| 1975-08-05 | vs OAK | 111 | W 15-2 | 52-59 | 4 | 22,380 | Clyde Wright | Sonny Siebert | Clyde Wright | Sonny Siebert | | 504 | 508 | -4 |
| 1975-08-06 | vs OAK | 112 | W 5-2 | 53-59 | 4 | 17,909 | Gaylord Perry | Stan Bahnsen | Gaylord Perry | Stan Bahnsen | | 509 | 510 | -1 |
| 1975-08-07 | vs OAK | 113 | L 1-10 | 53-60 | 4 | 20,373 | Jim Umbarger | Vida Blue | Vida Blue | Jim Umbarger | | 510 | 520 | -10 |
| 1975-08-08 | @ MIL | 114 | W 6-4 | 54-60 | 4 | 19,894 | Steve Hargan | Bill Travers | Steve Hargan | Bill Travers | Steve Foucault | 516 | 524 | -8 |
| 1975-08-09 | @ MIL | 115 | W 4-2 | 55-60 | 4 | 17,365 | Fergie Jenkins | Tom Hausman | Fergie Jenkins | Tom Hausman | | 520 | 526 | -6 |
| 1975-08-10 | @ MIL | 116 | L 4-7 | 55-61 | 4 | 13,893 | Bill Hands | Jim Colborn | Pete Broberg | Bill Hands | Tom Murphy | 524 | 533 | -9 |
| 1975-08-11 | @ DET | 117 | W 7-0 | 56-61 | 4 | 14,694 | Gaylord Perry | Lerrin LaGrow | Gaylord Perry | Lerrin LaGrow | | 531 | 533 | -2 |
| 1975-08-12 | @ DET | 118 | W 4-3 | 57-61 | 3 | 10,563 | Stan Perzanowski | Vern Ruhle | Stan Perzanowski | Vern Ruhle | Steve Foucault | 535 | 536 | -1 |
| 1975-08-13 | @ DET | 119 | W 6-5 | 58-61 | 3 | 10,263 | Fergie Jenkins | Joe Coleman | Steve Foucault | Gene Pentz | | 541 | 541 | 0 |
| 1975-08-15 | @ BAL | 120 | W 10-6 | 59-62 | 3 | 0 | Steve Hargan | Mike Torrez | Steve Foucault | Wayne Garland | | 551 | 547 | 4 |
| 1975-08-15 | @ BAL | 121 | L 1-13 | 59-62 | 3 | 18,636 | Clyde Wright | Mike Cuellar | Mike Cuellar | Clyde Wright | | 552 | 560 | -8 |
| 1975-08-16 | @ BAL | 122 | W 5-1 | 60-62 | 3 | 25,630 | Gaylord Perry | Ross Grimsley | Gaylord Perry | Ross Grimsley | | 557 | 561 | -4 |
| 1975-08-17 | @ BAL | 123 | L 0-4 | 60-63 | 3 | 11,123 | Stan Perzanowski | Jim Palmer | Jim Palmer | Stan Perzanowski | | 557 | 565 | -8 |
| 1975-08-18 | @ CLE | 124 | L 3-4 | 60-65 | 4 | 0 | Steve Hargan | Don Hood | Rick Waits | Steve Hargan | | 560 | 569 | -9 |
| 1975-08-18 | @ CLE | 125 | L 2-4 | 60-65 | 4 | 13,410 | Fergie Jenkins | Roric Harrison | Roric Harrison | Fergie Jenkins | Dave LaRoche | 562 | 573 | -11 |
| 1975-08-19 | @ CLE | 126 | W 2-1 | 61-65 | 4 | 8,894 | Jim Umbarger | Dennis Eckersley | Jim Umbarger | Dennis Eckersley | Steve Foucault | 564 | 574 | -10 |
| 1975-08-21 | vs BAL | 127 | L 2-4 | 61-66 | 4 | 16,575 | Gaylord Perry | Jim Palmer | Dyar Miller | Steve Foucault | | 566 | 578 | -12 |
| 1975-08-22 | vs BAL | 128 | L 5-8 | 61-67 | 4 | 36,825 | Stan Perzanowski | Mike Torrez | Mike Torrez | Stan Perzanowski | Grant Jackson | 571 | 586 | -15 |
| 1975-08-23 | vs BAL | 129 | W 1-0 | 62-67 | 4 | 14,637 | Fergie Jenkins | Mike Cuellar | Fergie Jenkins | Mike Cuellar | | 572 | 586 | -14 |
| 1975-08-24 | vs BAL | 130 | W 8-7 | 63-67 | 4 | 6,324 | Steve Hargan | Ross Grimsley | Steve Foucault | Wayne Garland | | 580 | 593 | -13 |
| 1975-08-25 | vs DET | 131 | W 1-0 | 64-67 | 3 | 5,458 | Jim Umbarger | Ray Bare | Jim Umbarger | Ray Bare | | 581 | 593 | -12 |
| 1975-08-26 | vs DET | 132 | W 3-2 | 65-67 | 3 | 7,308 | Gaylord Perry | Vern Ruhle | Gaylord Perry | Gene Pentz | | 584 | 595 | -11 |
| 1975-08-27 | vs DET | 133 | W 8-2 | 66-67 | 3 | 5,910 | Fergie Jenkins | Lerrin LaGrow | Fergie Jenkins | Lerrin LaGrow | | 592 | 597 | -5 |
| 1975-08-29 | vs MIL | 134 | L 1-13 | 66-68 | 3 | 13,496 | Steve Hargan | Jim Colborn | Jim Colborn | Steve Hargan | | 593 | 610 | -17 |
| 1975-08-30 | vs MIL | 135 | W 8-3 | 67-68 | 3 | 14,962 | Jim Umbarger | Jim Slaton | Jim Umbarger | Jim Slaton | | 601 | 613 | -12 |
| 1975-08-31 | vs MIL | 136 | L 1-4 | 67-69 | 3 | 15,037 | Gaylord Perry | Pete Broberg | Pete Broberg | Gaylord Perry | | 602 | 617 | -15 |
| 1975-09-01 | vs MIN | 137 | L 4-5 | 67-70 | 3 | 5,917 | Fergie Jenkins | Bert Blyleven | Bill Butler | Fergie Jenkins | Tom Johnson | 606 | 622 | -16 |
| 1975-09-02 | vs MIN | 138 | L 3-5 | 67-71 | 3 | 5,002 | Steve Hargan | Jim Hughes | Jim Hughes | Steve Hargan | Tom Burgmeier | 609 | 627 | -18 |
| 1975-09-03 | @ CAL | 139 | W 5-4 | 68-71 | 3 | 6,757 | Stan Perzanowski | Andy Hassler | Clyde Wright | Andy Hassler | Steve Foucault | 614 | 631 | -17 |
| 1975-09-04 | @ CAL | 140 | L 4-6 | 68-72 | 3 | 5,827 | Jim Umbarger | Don Kirkwood | Jim Brewer | Stan Thomas | | 618 | 637 | -19 |
| 1975-09-05 | @ OAK | 141 | W 4-2 | 69-72 | 3 | 10,958 | Gaylord Perry | Vida Blue | Gaylord Perry | Vida Blue | | 622 | 639 | -17 |
| 1975-09-06 | @ OAK | 142 | L 1-2 | 69-73 | 3 | 7,624 | Fergie Jenkins | Stan Bahnsen | Paul Lindblad | Fergie Jenkins | Rollie Fingers | 623 | 641 | -18 |
| 1975-09-07 | @ OAK | 143 | L 1-4 | 69-75 | 3 | 0 | Clyde Wright | Dick Bosman | Dick Bosman | Clyde Wright | Jim Todd | 624 | 645 | -21 |
| 1975-09-07 | @ OAK | 144 | L 3-7 | 69-75 | 3 | 15,705 | Steve Hargan | Sonny Siebert | Sonny Siebert | Steve Hargan | Rollie Fingers | 627 | 652 | -25 |
| 1975-09-09 | @ MIN | 145 | W 3-0 | 71-75 | 3 | 0 | Jim Umbarger | Dave Goltz | Jim Umbarger | Dave Goltz | | 630 | 652 | -22 |
| 1975-09-09 | @ MIN | 146 | W 4-2 | 71-75 | 3 | 4,300 | Stan Perzanowski | Bill Butler | Stan Perzanowski | Tom Johnson | Steve Foucault | 634 | 654 | -20 |
| 1975-09-10 | @ MIN | 147 | W 9-4 | 72-75 | 3 | 3,339 | Gaylord Perry | Bert Blyleven | Gaylord Perry | Bert Blyleven | | 643 | 658 | -15 |
| 1975-09-12 | vs CHA | 148 | L 2-5 | 72-76 | 3 | 6,007 | Fergie Jenkins | Jesse Jefferson | Rich Hinton | Fergie Jenkins | Rich Gossage | 645 | 663 | -18 |
| 1975-09-13 | vs CHA | 149 | W 8-7 | 73-76 | 3 | 11,102 | Jim Umbarger | Wilbur Wood | Steve Foucault | Dave Hamilton | | 653 | 670 | -17 |
| 1975-09-14 | vs CHA | 150 | W 9-8 | 74-76 | 3 | 6,705 | Jim Gideon | Jim Kaat | Steve Foucault | Dave Hamilton | | 662 | 678 | -16 |
| 1975-09-16 | vs OAK | 151 | L 5-11 | 74-78 | 3 | 0 | Gaylord Perry | Vida Blue | Jim Todd | Gaylord Perry | | 667 | 689 | -22 |
| 1975-09-16 | vs OAK | 152 | L 4-6 | 74-78 | 3 | 12,684 | Fergie Jenkins | Stan Bahnsen | Stan Bahnsen | Fergie Jenkins | Rollie Fingers | 671 | 695 | -24 |
| 1975-09-17 | vs CAL | 153 | L 2-3 | 74-79 | 3 | 4,942 | David Clyde | Ed Figueroa | Ed Figueroa | David Clyde | | 673 | 698 | -25 |
| 1975-09-18 | vs CAL | 154 | L 3-5 | 74-80 | 3 | 4,440 | Jim Umbarger | Frank Tanana | Frank Tanana | Jim Umbarger | | 676 | 703 | -27 |
| 1975-09-19 | @ CHA | 155 | W 10-6 | 75-80 | 3 | 3,723 | Steve Hargan | Claude Osteen | Steve Hargan | Claude Osteen | Stan Thomas | 686 | 709 | -23 |
| 1975-09-20 | @ CHA | 156 | W 5-3 | 76-80 | 3 | 4,732 | Fergie Jenkins | Jesse Jefferson | Fergie Jenkins | Jesse Jefferson | | 691 | 712 | -21 |
| 1975-09-21 | @ CHA | 157 | W 8-2 | 77-80 | 3 | 4,174 | Gaylord Perry | Wilbur Wood | Gaylord Perry | Wilbur Wood | | 699 | 714 | -15 |
| 1975-09-22 | @ KCA | 158 | L 1-2 | 77-81 | 3 | 6,180 | Stan Perzanowski | Al Fitzmorris | Al Fitzmorris | Steve Foucault | | 700 | 716 | -16 |
| 1975-09-23 | @ KCA | 159 | L 0-4 | 77-82 | 3 | 6,451 | Jim Umbarger | Doug Bird | Bob McClure | Jim Umbarger | | 700 | 720 | -20 |
| 1975-09-26 | vs KCA | 160 | L 6-8 | 77-83 | 4 | 7,310 | Fergie Jenkins | Dennis Leonard | Dennis Leonard | Fergie Jenkins | Marty Pattin | 706 | 728 | -22 |
| 1975-09-27 | vs KCA | 161 | W 5-4 | 78-83 | 3 | 18,003 | Gaylord Perry | Al Fitzmorris | Gaylord Perry | Al Fitzmorris | | 711 | 732 | -21 |
| 1975-09-28 | vs KCA | 162 | W 3-1 | 79-83 | 3 | 6,470 | Stan Perzanowski | Mark Littell | Stan Perzanowski | Mark Littell | Steve Foucault | 714 | 733 | -19 |