| 1975-04-07 | vs MON | 1 | L 4-8 | 0-1 | 6 | 31,769 | Bob Gibson | Dave McNally | Dave McNally | Bob Gibson | Dale Murray | 4 | 8 | -4 |
| 1975-04-09 | vs MON | 2 | W 4-0 | 1-1 | 3 | 7,469 | Bob Forsch | Steve Rogers | Bob Forsch | Steve Rogers | | 8 | 8 | 0 |
| 1975-04-10 | vs MON | 3 | W 7-2 | 2-1 | 2 | 11,086 | John Denny | Woodie Fryman | John Denny | Dale Murray | Al Hrabosky | 15 | 10 | 5 |
| 1975-04-11 | @ PHI | 4 | W 6-3 | 3-1 | 2 | 44,834 | Lynn McGlothen | Wayne Twitchell | Lynn McGlothen | Wayne Twitchell | Al Hrabosky | 21 | 13 | 8 |
| 1975-04-12 | @ PHI | 5 | W 7-5 | 4-1 | 2 | 11,101 | Bob Gibson | Steve Carlton | Mike Garman | Gene Garber | | 28 | 18 | 10 |
| 1975-04-13 | @ PHI | 6 | L 0-2 | 4-2 | 3 | 13,539 | Bob Forsch | Tom Underwood | Tom Underwood | Bob Forsch | | 28 | 20 | 8 |
| 1975-04-16 | vs NYN | 7 | W 3-2 | 5-2 | 2 | 11,691 | John Denny | Jon Matlack | John Denny | Jon Matlack | Mike Garman | 31 | 22 | 9 |
| 1975-04-17 | vs NYN | 8 | L 7-14 | 5-3 | 2 | 12,004 | Lynn McGlothen | Jerry Koosman | Rick Baldwin | Elias Sosa | | 38 | 36 | 2 |
| 1975-04-18 | vs PIT | 9 | W 5-4 | 6-3 | 2 | 19,975 | Bob Gibson | Bruce Kison | Ray Sadecki | Sam McDowell | | 43 | 40 | 3 |
| 1975-04-19 | vs PIT | 10 | L 1-7 | 6-4 | 2 | 19,775 | Bob Forsch | Jim Rooker | Jim Rooker | Bob Forsch | | 44 | 47 | -3 |
| 1975-04-20 | vs PIT | 11 | L 0-5 | 6-5 | 3 | 20,935 | John Denny | Ken Brett | Ken Brett | John Denny | Dave Giusti | 44 | 52 | -8 |
| 1975-04-22 | @ NYN | 12 | L 5-9 | 6-6 | 4 | 9,318 | Lynn McGlothen | Jerry Koosman | Jerry Koosman | Lynn McGlothen | | 49 | 61 | -12 |
| 1975-04-23 | @ NYN | 13 | L 1-7 | 6-7 | 4 | 14,120 | Bob Gibson | Tom Seaver | Tom Seaver | Bob Gibson | | 50 | 68 | -18 |
| 1975-04-25 | @ CHN | 14 | L 3-4 | 6-8 | 5 | 7,466 | Bob Forsch | Rick Reuschel | Darold Knowles | Al Hrabosky | | 53 | 72 | -19 |
| 1975-04-26 | @ CHN | 15 | L 6-8 | 6-9 | 5 | 20,874 | John Denny | Bill Bonham | Ken Frailing | John Curtis | Oscar Zamora | 59 | 80 | -21 |
| 1975-04-29 | @ PIT | 16 | W 3-0 | 7-9 | 4 | 6,319 | Lynn McGlothen | Ken Brett | Lynn McGlothen | Ken Brett | | 62 | 80 | -18 |
| 1975-04-30 | @ PIT | 17 | L 0-5 | 7-10 | 5 | 5,584 | Bob Gibson | Jerry Reuss | Jerry Reuss | Bob Gibson | | 62 | 85 | -23 |
| 1975-05-02 | vs CHN | 18 | W 5-1 | 8-10 | 5 | 23,017 | Bob Forsch | Rick Reuschel | Bob Forsch | Rick Reuschel | | 67 | 86 | -19 |
| 1975-05-03 | vs CHN | 19 | L 3-7 | 8-11 | 5 | 24,224 | John Denny | Bill Bonham | Bill Bonham | Mike Garman | Darold Knowles | 70 | 93 | -23 |
| 1975-05-04 | vs CHN | 20 | L 6-8 | 8-12 | 5 | 22,980 | Lynn McGlothen | Geoff Zahn | Oscar Zamora | Lynn McGlothen | Darold Knowles | 76 | 101 | -25 |
| 1975-05-05 | vs PHI | 21 | W 11-3 | 9-12 | 5 | 9,198 | Bob Gibson | Steve Carlton | Bob Gibson | Steve Carlton | | 87 | 104 | -17 |
| 1975-05-07 | vs PHI | 22 | L 1-4 | 9-13 | 5 | 9,735 | Bob Forsch | Wayne Twitchell | Wayne Twitchell | Bob Forsch | Tug McGraw | 88 | 108 | -20 |
| 1975-05-08 | vs PHI | 23 | L 2-6 | 9-14 | 5 | 10,293 | John Denny | Jim Lonborg | Jim Lonborg | John Denny | | 90 | 114 | -24 |
| 1975-05-09 | vs SFN | 24 | W 6-4 | 10-14 | 5 | 21,410 | Lynn McGlothen | John D'Acquisto | Lynn McGlothen | John D'Acquisto | Al Hrabosky | 96 | 118 | -22 |
| 1975-05-10 | vs SFN | 25 | W 9-2 | 11-14 | 4 | 18,919 | John Curtis | Charlie Williams | John Curtis | Charlie Williams | | 105 | 120 | -15 |
| 1975-05-11 | vs SFN | 26 | W 4-3 | 12-14 | 4 | 10,692 | Bob Forsch | Pete Falcone | Bob Forsch | Pete Falcone | Al Hrabosky | 109 | 123 | -14 |
| 1975-05-12 | vs LAN | 27 | L 4-6 | 12-15 | 5 | 13,342 | John Denny | Andy Messersmith | Jim Brewer | Mike Garman | | 113 | 129 | -16 |
| 1975-05-13 | vs LAN | 28 | L 0-5 | 12-16 | 5 | 18,519 | Lynn McGlothen | Burt Hooton | Burt Hooton | Lynn McGlothen | | 113 | 134 | -21 |
| 1975-05-14 | vs LAN | 29 | W 7-4 | 13-16 | 5 | 14,388 | John Curtis | Doug Rau | John Curtis | Doug Rau | Al Hrabosky | 120 | 138 | -18 |
| 1975-05-16 | @ SFN | 30 | L 3-4 | 13-17 | 6 | 5,764 | Bob Gibson | John Montefusco | Gary Lavelle | Elias Sosa | | 123 | 142 | -19 |
| 1975-05-17 | @ SFN | 31 | W 17-2 | 14-17 | 5 | 6,891 | Bob Forsch | Pete Falcone | Bob Forsch | Pete Falcone | | 140 | 144 | -4 |
| 1975-05-18 | @ SFN | 32 | L 0-2 | 14-18 | 5 | 11,332 | Lynn McGlothen | Jim Barr | Jim Barr | Lynn McGlothen | | 140 | 146 | -6 |
| 1975-05-19 | @ SDN | 33 | L 0-1 | 14-19 | 5 | 10,111 | John Curtis | Randy Jones | Randy Jones | John Curtis | | 140 | 147 | -7 |
| 1975-05-20 | @ SDN | 34 | L 2-5 | 14-20 | 5 | 7,318 | Elias Sosa | Alan Foster | Alan Foster | Elias Sosa | | 142 | 152 | -10 |
| 1975-05-21 | @ SDN | 35 | L 0-1 | 14-21 | 5 | 13,163 | Bob Gibson | Joe McIntosh | Joe McIntosh | Bob Gibson | | 142 | 153 | -11 |
| 1975-05-23 | @ LAN | 36 | W 4-3 | 15-21 | 5 | 53,033 | Bob Forsch | Al Downing | Al Hrabosky | Charlie Hough | Mike Garman | 146 | 156 | -10 |
| 1975-05-24 | @ LAN | 37 | W 6-2 | 16-21 | 5 | 45,196 | Lynn McGlothen | Doug Rau | Lynn McGlothen | Doug Rau | Al Hrabosky | 152 | 158 | -6 |
| 1975-05-25 | @ LAN | 38 | L 3-7 | 16-22 | 5 | 43,958 | John Curtis | Don Sutton | Don Sutton | John Curtis | | 155 | 165 | -10 |
| 1975-05-26 | vs SDN | 39 | L 6-9 | 16-23 | 5 | 12,430 | Bob Gibson | Joe McIntosh | Bill Greif | Al Hrabosky | Danny Frisella | 161 | 174 | -13 |
| 1975-05-27 | vs SDN | 40 | W 7-1 | 17-23 | 5 | 10,060 | Bob Forsch | Dave Freisleben | Bob Forsch | Dave Freisleben | | 168 | 175 | -7 |
| 1975-05-28 | vs SDN | 41 | W 6-5 | 18-23 | 5 | 11,690 | Lynn McGlothen | Dan Spillner | Mike Garman | Bill Greif | | 174 | 180 | -6 |
| 1975-05-30 | vs CIN | 42 | W 5-4 | 19-23 | 5 | 21,930 | John Curtis | Clay Kirby | Al Hrabosky | Rawly Eastwick | | 179 | 184 | -5 |
| 1975-05-31 | vs CIN | 43 | L 0-6 | 19-24 | 5 | 28,475 | Bob Gibson | Don Gullett | Don Gullett | Bob Gibson | | 179 | 190 | -11 |
| 1975-06-01 | vs CIN | 44 | L 1-5 | 19-25 | 5 | 25,231 | Bob Forsch | Jack Billingham | Jack Billingham | Bob Forsch | | 180 | 195 | -15 |
| 1975-06-02 | vs ATL | 45 | W 1-0 | 20-25 | 5 | 12,001 | Lynn McGlothen | Carl Morton | Lynn McGlothen | Carl Morton | | 181 | 195 | -14 |
| 1975-06-03 | vs ATL | 46 | W 4-2 | 21-25 | 5 | 13,356 | Ron Reed | Buzz Capra | Ron Reed | Buzz Capra | Al Hrabosky | 185 | 197 | -12 |
| 1975-06-04 | vs ATL | 47 | W 5-2 | 22-25 | 5 | 12,570 | John Curtis | Ray Sadecki | John Curtis | Ray Sadecki | Al Hrabosky | 190 | 199 | -9 |
| 1975-06-06 | @ HOU | 48 | W 6-0 | 23-25 | 5 | 12,955 | Bob Forsch | Larry Dierker | Bob Forsch | Larry Dierker | | 196 | 199 | -3 |
| 1975-06-07 | @ HOU | 49 | W 5-1 | 24-25 | 5 | 13,990 | Lynn McGlothen | Dave Roberts | Lynn McGlothen | Dave Roberts | | 201 | 200 | 1 |
| 1975-06-08 | @ HOU | 50 | W 5-1 | 25-25 | 5 | 12,288 | Ron Reed | Ken Forsch | Ron Reed | Ken Forsch | Al Hrabosky | 206 | 201 | 5 |
| 1975-06-09 | @ ATL | 51 | W 5-4 | 26-25 | 5 | 9,620 | John Curtis | Blue Moon Odom | John Curtis | Blue Moon Odom | Al Hrabosky | 211 | 205 | 6 |
| 1975-06-11 | @ CIN | 52 | L 1-3 | 26-26 | 5 | 22,103 | Bob Forsch | Don Gullett | Don Gullett | Bob Forsch | | 212 | 208 | 4 |
| 1975-06-12 | @ CIN | 53 | L 1-10 | 26-27 | 5 | 24,512 | Lynn McGlothen | Gary Nolan | Gary Nolan | Lynn McGlothen | | 213 | 218 | -5 |
| 1975-06-13 | vs HOU | 54 | W 6-2 | 27-27 | 5 | 20,557 | Ron Reed | Paul Siebert | Ron Reed | Paul Siebert | | 219 | 220 | -1 |
| 1975-06-14 | vs HOU | 55 | L 0-9 | 27-28 | 5 | 25,122 | John Curtis | Tom Griffin | Tom Griffin | John Curtis | | 219 | 229 | -10 |
| 1975-06-15 | vs HOU | 56 | L 7-8 | 27-29 | 5 | 33,201 | Bob Forsch | Doug Konieczny | Joe Niekro | Mike Garman | | 226 | 237 | -11 |
| 1975-06-16 | @ PIT | 57 | L 4-10 | 27-30 | 5 | 13,003 | Ron Bryant | Bruce Kison | Bruce Kison | Ron Bryant | | 230 | 247 | -17 |
| 1975-06-17 | @ PIT | 58 | W 7-4 | 28-30 | 5 | 15,898 | Lynn McGlothen | Dock Ellis | Lynn McGlothen | Dock Ellis | Mike Garman | 237 | 251 | -14 |
| 1975-06-18 | @ PIT | 59 | L 3-9 | 28-31 | 5 | 22,345 | Ron Reed | Jim Rooker | Jim Rooker | Ron Reed | | 240 | 260 | -20 |
| 1975-06-19 | @ PIT | 60 | L 0-5 | 28-32 | 5 | 8,198 | John Curtis | Jerry Reuss | Jerry Reuss | John Curtis | | 240 | 265 | -25 |
| 1975-06-20 | vs CHN | 61 | W 8-3 | 29-32 | 5 | 25,841 | Bob Forsch | Geoff Zahn | Bob Forsch | Geoff Zahn | | 248 | 268 | -20 |
| 1975-06-21 | vs CHN | 62 | L 1-6 | 29-33 | 5 | 42,914 | Bob Gibson | Rick Reuschel | Rick Reuschel | Bob Gibson | | 249 | 274 | -25 |
| 1975-06-22 | vs CHN | 63 | W 7-2 | 30-33 | 5 | 35,102 | Lynn McGlothen | Steve Stone | Lynn McGlothen | Steve Stone | | 256 | 276 | -20 |
| 1975-06-23 | @ NYN | 64 | W 1-0 | 32-33 | 5 | 0 | Ron Reed | Hank Webb | Ron Reed | Hank Webb | | 257 | 276 | -19 |
| 1975-06-23 | @ NYN | 65 | W 4-0 | 32-33 | 5 | 32,719 | John Denny | George Stone | John Denny | George Stone | | 261 | 276 | -15 |
| 1975-06-24 | @ NYN | 66 | L 1-5 | 32-34 | 5 | 19,240 | John Curtis | Jerry Koosman | Jerry Koosman | John Curtis | | 262 | 281 | -19 |
| 1975-06-25 | @ NYN | 67 | L 1-2 | 32-35 | 5 | 21,303 | Bob Forsch | Tom Seaver | Tom Seaver | Bob Forsch | Rick Baldwin | 263 | 283 | -20 |
| 1975-06-26 | @ MON | 68 | W 4-3 | 33-35 | 5 | 11,173 | Lynn McGlothen | Woodie Fryman | Lynn McGlothen | Woodie Fryman | Mike Garman | 267 | 286 | -19 |
| 1975-06-27 | @ MON | 69 | W 6-4 | 34-36 | 4 | 0 | Bob Gibson | Steve Rogers | Bob Gibson | Steve Rogers | Mike Garman | 273 | 290 | -17 |
| 1975-06-27 | @ MON | 70 | L 4-5 | 34-36 | 4 | 20,089 | Ron Reed | Don Stanhouse | Dan Warthen | Ron Reed | | 277 | 295 | -18 |
| 1975-06-28 | @ MON | 71 | W 3-2 | 35-36 | 4 | 18,640 | John Denny | Fred Scherman | Al Hrabosky | Don DeMola | Mike Garman | 280 | 297 | -17 |
| 1975-06-29 | @ MON | 72 | L 3-7 | 35-37 | 4 | 15,258 | John Curtis | Steve Renko | Steve Renko | John Curtis | | 283 | 304 | -21 |
| 1975-06-30 | @ PHI | 73 | W 4-2 | 36-37 | 4 | 28,264 | Bob Forsch | Jim Lonborg | Bob Forsch | Jim Lonborg | Al Hrabosky | 287 | 306 | -19 |
| 1975-07-01 | @ PHI | 74 | W 6-5 | 37-37 | 4 | 22,544 | Lynn McGlothen | Wayne Twitchell | Lynn McGlothen | Wayne Twitchell | Al Hrabosky | 293 | 311 | -18 |
| 1975-07-02 | @ PHI | 75 | L 3-5 | 37-38 | 4 | 21,843 | Ron Reed | Steve Carlton | Steve Carlton | Ron Reed | | 296 | 316 | -20 |
| 1975-07-03 | @ PHI | 76 | L 4-7 | 37-39 | 4 | 16,068 | Bob Gibson | Tom Underwood | Tom Underwood | Bob Gibson | | 300 | 323 | -23 |
| 1975-07-04 | vs MON | 77 | L 1-5 | 37-40 | 4 | 22,107 | John Denny | Steve Renko | Steve Renko | John Denny | Dan Warthen | 301 | 328 | -27 |
| 1975-07-05 | vs MON | 78 | L 0-3 | 38-41 | 4 | 0 | Bob Forsch | Dennis Blair | Dennis Blair | Bob Forsch | Dan Warthen | 301 | 331 | -30 |
| 1975-07-05 | vs MON | 79 | W 1-0 | 38-41 | 4 | 35,141 | John Curtis | Woodie Fryman | John Curtis | Woodie Fryman | Al Hrabosky | 302 | 331 | -29 |
| 1975-07-06 | vs MON | 80 | L 3-4 | 38-42 | 4 | 23,967 | Lynn McGlothen | Fred Scherman | Don DeMola | Lynn McGlothen | | 305 | 335 | -30 |
| 1975-07-07 | vs SFN | 81 | W 8-6 | 39-42 | 4 | 15,498 | Ron Reed | Mike Caldwell | Ron Reed | Mike Caldwell | Al Hrabosky | 313 | 341 | -28 |
| 1975-07-08 | vs SFN | 82 | L 4-6 | 39-43 | 4 | 15,926 | Bob Gibson | Pete Falcone | Pete Falcone | Bob Gibson | Gary Lavelle | 317 | 347 | -30 |
| 1975-07-09 | vs SFN | 83 | W 9-0 | 40-43 | 4 | 14,762 | John Denny | John Montefusco | John Denny | John Montefusco | | 326 | 347 | -21 |
| 1975-07-11 | vs LAN | 84 | L 5-6 | 40-44 | 4 | 32,007 | Bob Forsch | Doug Rau | Mike Marshall | Mike Garman | | 331 | 353 | -22 |
| 1975-07-12 | vs LAN | 85 | W 2-1 | 41-44 | 4 | 31,606 | Lynn McGlothen | Al Downing | Al Hrabosky | Rick Rhoden | | 333 | 354 | -21 |
| 1975-07-13 | vs LAN | 86 | W 2-1 | 42-44 | 4 | 32,567 | Ron Reed | Andy Messersmith | Al Hrabosky | Mike Marshall | | 335 | 355 | -20 |
| 1975-07-17 | @ SFN | 87 | W 1-0 | 43-44 | 4 | 3,085 | John Denny | Jim Barr | Al Hrabosky | Jim Barr | | 336 | 355 | -19 |
| 1975-07-18 | @ SFN | 88 | L 1-2 | 43-45 | 4 | 3,291 | Bob Forsch | Pete Falcone | Gary Lavelle | Greg Terlecky | | 337 | 357 | -20 |
| 1975-07-19 | @ SFN | 89 | L 2-5 | 43-46 | 4 | 7,136 | Lynn McGlothen | John Montefusco | John Montefusco | Lynn McGlothen | | 339 | 362 | -23 |
| 1975-07-20 | @ SDN | 90 | W 3-1 | 45-46 | 4 | 0 | Ron Reed | Joe McIntosh | Al Hrabosky | Bill Greif | | 342 | 363 | -21 |
| 1975-07-20 | @ SDN | 91 | W 10-2 | 45-46 | 4 | 24,031 | John Curtis | Rich Folkers | John Curtis | Rich Folkers | | 352 | 365 | -13 |
| 1975-07-21 | @ SDN | 92 | W 4-0 | 46-46 | 4 | 7,493 | Eric Rasmussen | Brent Strom | Eric Rasmussen | Brent Strom | | 356 | 365 | -9 |
| 1975-07-22 | @ LAN | 93 | W 4-3 | 47-46 | 4 | 25,958 | John Denny | Doug Rau | Al Hrabosky | Mike Marshall | | 360 | 368 | -8 |
| 1975-07-23 | @ LAN | 94 | W 5-4 | 48-46 | 4 | 27,772 | Bob Forsch | Don Sutton | Bob Forsch | Don Sutton | Mike Garman | 365 | 372 | -7 |
| 1975-07-24 | @ LAN | 95 | L 2-8 | 48-47 | 4 | 26,982 | Lynn McGlothen | Burt Hooton | Burt Hooton | Lynn McGlothen | | 367 | 380 | -13 |
| 1975-07-25 | vs PHI | 96 | W 4-3 | 49-48 | 4 | 0 | Ron Reed | Tom Underwood | Al Hrabosky | Gene Garber | | 371 | 383 | -12 |
| 1975-07-25 | vs PHI | 97 | L 2-5 | 49-48 | 4 | 36,127 | John Curtis | Ron Schueler | Ron Schueler | John Curtis | Tug McGraw | 373 | 388 | -15 |
| 1975-07-26 | vs PHI | 98 | L 4-9 | 49-49 | 4 | 36,350 | Eric Rasmussen | Steve Carlton | Steve Carlton | Eric Rasmussen | | 377 | 397 | -20 |
| 1975-07-27 | vs PHI | 99 | W 9-6 | 50-49 | 4 | 22,046 | John Denny | Jim Lonborg | Bob Gibson | Tom Hilgendorf | Mike Garman | 386 | 403 | -17 |
| 1975-07-28 | vs NYN | 100 | L 7-11 | 50-50 | 4 | 19,406 | Bob Forsch | Jon Matlack | Jon Matlack | Bob Forsch | Bob Apodaca | 393 | 414 | -21 |
| 1975-07-29 | vs NYN | 101 | W 5-3 | 51-51 | 4 | 0 | Lynn McGlothen | Tom Seaver | Lynn McGlothen | Tom Seaver | Mike Garman | 398 | 417 | -19 |
| 1975-07-29 | vs NYN | 102 | L 6-11 | 51-51 | 4 | 31,431 | Ron Reed | Tom Hall | Tom Hall | Ron Reed | Rick Baldwin | 404 | 428 | -24 |
| 1975-07-30 | vs NYN | 103 | W 5-2 | 52-51 | 4 | 14,226 | John Curtis | Randy Tate | John Curtis | Randy Tate | | 409 | 430 | -21 |
| 1975-07-31 | @ CHN | 104 | L 3-5 | 52-52 | 4 | 19,058 | Eric Rasmussen | Steve Stone | Paul Reuschel | Ken Reynolds | | 412 | 435 | -23 |
| 1975-08-01 | @ CHN | 105 | W 9-4 | 53-52 | 4 | 18,038 | John Denny | Bill Bonham | John Denny | Bill Bonham | Bob Gibson | 421 | 439 | -18 |
| 1975-08-02 | @ CHN | 106 | W 4-0 | 54-52 | 4 | 17,524 | Bob Forsch | Rick Reuschel | Bob Forsch | Rick Reuschel | | 425 | 439 | -14 |
| 1975-08-03 | @ CHN | 107 | L 3-6 | 55-53 | 4 | 0 | Lynn McGlothen | Tom Dettore | Tom Dettore | Al Hrabosky | Darold Knowles | 428 | 445 | -17 |
| 1975-08-03 | @ CHN | 108 | W 7-4 | 55-53 | 4 | 32,691 | Ron Reed | Ray Burris | Ron Reed | Ray Burris | | 435 | 449 | -14 |
| 1975-08-04 | vs PIT | 109 | W 5-4 | 56-53 | 4 | 28,097 | John Curtis | Jerry Reuss | John Curtis | Jerry Reuss | Al Hrabosky | 440 | 453 | -13 |
| 1975-08-05 | vs PIT | 110 | L 1-6 | 56-54 | 4 | 25,489 | Eric Rasmussen | Jim Rooker | Jim Rooker | Eric Rasmussen | | 441 | 459 | -18 |
| 1975-08-06 | vs PIT | 111 | W 4-2 | 57-54 | 4 | 23,985 | John Denny | Ken Brett | John Denny | Ken Brett | Al Hrabosky | 445 | 461 | -16 |
| 1975-08-08 | vs SDN | 112 | W 10-6 | 58-54 | 4 | 23,534 | Bob Forsch | Dan Spillner | Bob Forsch | Dan Spillner | | 455 | 467 | -12 |
| 1975-08-09 | vs SDN | 113 | W 6-1 | 59-54 | 3 | 25,031 | Lynn McGlothen | Dave Freisleben | Lynn McGlothen | Dave Freisleben | | 461 | 468 | -7 |
| 1975-08-10 | vs SDN | 114 | W 3-2 | 60-54 | 3 | 26,474 | Ron Reed | Joe McIntosh | Al Hrabosky | Bill Greif | | 464 | 470 | -6 |
| 1975-08-11 | @ HOU | 115 | L 2-7 | 60-55 | 3 | 10,550 | John Curtis | Larry Dierker | Larry Dierker | John Curtis | | 466 | 477 | -11 |
| 1975-08-12 | @ HOU | 116 | W 5-4 | 61-55 | 3 | 10,676 | John Denny | Dave Roberts | John Denny | Dave Roberts | Al Hrabosky | 471 | 481 | -10 |
| 1975-08-13 | @ HOU | 117 | W 4-3 | 62-55 | 3 | 11,170 | Bob Forsch | Joe Niekro | Mike Garman | Mike Cosgrove | Bob Gibson | 475 | 484 | -9 |
| 1975-08-14 | @ ATL | 118 | L 4-6 | 62-56 | 3 | 4,188 | Lynn McGlothen | Phil Niekro | Phil Niekro | Lynn McGlothen | Ray Sadecki | 479 | 490 | -11 |
| 1975-08-15 | @ ATL | 119 | W 4-1 | 64-56 | 3 | 0 | Ron Reed | Jamie Easterly | Ron Reed | Jamie Easterly | | 483 | 491 | -8 |
| 1975-08-15 | @ ATL | 120 | W 2-1 | 64-56 | 3 | 8,771 | Eric Rasmussen | Mike Thompson | Eric Rasmussen | Mike Thompson | Al Hrabosky | 485 | 492 | -7 |
| 1975-08-16 | @ ATL | 121 | L 7-8 | 64-57 | 3 | 16,255 | John Curtis | Carl Morton | Tom House | Bob Gibson | | 492 | 500 | -8 |
| 1975-08-17 | @ ATL | 122 | W 8-1 | 65-57 | 3 | 8,907 | John Denny | Blue Moon Odom | John Denny | Blue Moon Odom | | 500 | 501 | -1 |
| 1975-08-18 | vs CIN | 123 | L 2-3 | 65-58 | 3 | 35,937 | Bob Forsch | Don Gullett | Don Gullett | Bob Forsch | Rawly Eastwick | 502 | 504 | -2 |
| 1975-08-19 | vs CIN | 124 | W 2-1 | 66-58 | 3 | 34,977 | Lynn McGlothen | Gary Nolan | Lynn McGlothen | Gary Nolan | | 504 | 505 | -1 |
| 1975-08-20 | vs CIN | 125 | W 4-0 | 67-58 | 3 | 37,164 | Ron Reed | Fred Norman | Ron Reed | Fred Norman | | 508 | 505 | 3 |
| 1975-08-22 | vs ATL | 126 | L 5-9 | 67-59 | 3 | 23,769 | Eric Rasmussen | Jamie Easterly | Elias Sosa | Harry Parker | Tom House | 513 | 514 | -1 |
| 1975-08-23 | vs ATL | 127 | W 7-2 | 68-59 | 3 | 30,930 | John Denny | Phil Niekro | John Denny | Phil Niekro | | 520 | 516 | 4 |
| 1975-08-24 | vs ATL | 128 | W 6-2 | 69-59 | 3 | 24,786 | Bob Forsch | Carl Morton | Bob Forsch | Carl Morton | Al Hrabosky | 526 | 518 | 8 |
| 1975-08-25 | vs HOU | 129 | W 3-3 | 70-59 | 3 | 11,267 | Lynn McGlothen | Dave Roberts | | | | 529 | 521 | 8 |
| 1975-08-26 | vs HOU | 130 | W 10-9 | 72-59 | 2 | 0 | Ron Reed | J.R. Richard | Al Hrabosky | Jose Sosa | | 539 | 530 | 9 |
| 1975-08-26 | vs HOU | 131 | W 2-1 | 72-59 | 2 | 19,185 | Eric Rasmussen | Doug Konieczny | Eric Rasmussen | Doug Konieczny | | 541 | 531 | 10 |
| 1975-08-27 | vs HOU | 132 | L 1-5 | 72-60 | 2 | 13,778 | John Denny | Jim York | Jim York | John Denny | | 542 | 536 | 6 |
| 1975-08-28 | @ CIN | 133 | L 0-4 | 72-61 | 2 | 30,345 | Bob Forsch | Don Gullett | Don Gullett | Mike Garman | | 542 | 540 | 2 |
| 1975-08-29 | @ CIN | 134 | L 2-6 | 72-62 | 3 | 33,290 | Lynn McGlothen | Gary Nolan | Gary Nolan | Lynn McGlothen | Will McEnaney | 544 | 546 | -2 |
| 1975-08-30 | @ CIN | 135 | L 2-3 | 72-63 | 3 | 45,064 | Ron Reed | Fred Norman | Rawly Eastwick | Mike Garman | | 546 | 549 | -3 |
| 1975-08-31 | @ CIN | 136 | W 5-3 | 73-63 | 2 | 43,470 | Eric Rasmussen | Jack Billingham | Eric Rasmussen | Jack Billingham | John Curtis | 551 | 552 | -1 |
| 1975-09-01 | vs CHN | 137 | W 6-3 | 74-63 | 2 | 48,435 | Bob Forsch | Bill Bonham | Bob Forsch | Bill Bonham | Al Hrabosky | 557 | 555 | 2 |
| 1975-09-02 | vs CHN | 138 | L 3-5 | 74-64 | 2 | 13,049 | Lynn McGlothen | Ray Burris | Ray Burris | Lynn McGlothen | Paul Reuschel | 560 | 560 | 0 |
| 1975-09-03 | vs CHN | 139 | L 6-11 | 74-65 | 2 | 14,119 | Ron Reed | Willie Prall | Buddy Schultz | Bob Gibson | Paul Reuschel | 566 | 571 | -5 |
| 1975-09-05 | @ NYN | 140 | L 2-5 | 74-66 | 3 | 27,093 | Eric Rasmussen | Tom Seaver | Tom Seaver | Eric Rasmussen | Bob Apodaca | 568 | 576 | -8 |
| 1975-09-06 | @ NYN | 141 | W 6-3 | 75-66 | 2 | 17,032 | Bob Forsch | Jerry Koosman | Bob Forsch | Jerry Koosman | Al Hrabosky | 574 | 579 | -5 |
| 1975-09-07 | @ NYN | 142 | W 12-4 | 76-66 | 2 | 25,810 | Lynn McGlothen | Jon Matlack | Lynn McGlothen | Jon Matlack | | 586 | 583 | 3 |
| 1975-09-08 | @ PHI | 143 | L 3-6 | 76-67 | 2 | 22,768 | Ron Reed | Tom Underwood | Tom Underwood | Ron Reed | Tug McGraw | 589 | 589 | 0 |
| 1975-09-09 | @ PHI | 144 | L 2-6 | 76-68 | 3 | 13,764 | John Denny | Steve Carlton | Steve Carlton | John Denny | | 591 | 595 | -4 |
| 1975-09-10 | @ CHN | 145 | L 5-7 | 76-69 | 3 | 5,031 | Eric Rasmussen | Steve Stone | Buddy Schultz | Eric Rasmussen | Darold Knowles | 596 | 602 | -6 |
| 1975-09-11 | @ CHN | 146 | L 6-12 | 76-70 | 3 | 3,635 | Bob Forsch | Rick Reuschel | Oscar Zamora | Bob Forsch | Darold Knowles | 602 | 614 | -12 |
| 1975-09-12 | vs NYN | 147 | W 5-1 | 77-70 | 3 | 14,731 | Lynn McGlothen | Jon Matlack | Lynn McGlothen | Jon Matlack | | 607 | 615 | -8 |
| 1975-09-13 | vs NYN | 148 | L 2-6 | 77-71 | 3 | 27,627 | Ron Reed | Hank Webb | Hank Webb | Ron Reed | | 609 | 621 | -12 |
| 1975-09-14 | vs NYN | 149 | W 6-2 | 78-71 | 3 | 50,548 | John Denny | Tom Seaver | John Denny | Tom Seaver | Mike Garman | 615 | 623 | -8 |
| 1975-09-15 | vs PHI | 150 | W 7-6 | 79-71 | 3 | 9,955 | Eric Rasmussen | Larry Christenson | Al Hrabosky | Gene Garber | Harry Parker | 622 | 629 | -7 |
| 1975-09-16 | vs PHI | 151 | L 3-4 | 79-72 | 3 | 11,239 | Bob Forsch | Wayne Simpson | Tom Hilgendorf | Mike Garman | Gene Garber | 625 | 633 | -8 |
| 1975-09-17 | vs MON | 152 | L 3-6 | 79-73 | 3 | 5,883 | Lynn McGlothen | Dan Warthen | Dan Warthen | Lynn McGlothen | | 628 | 639 | -11 |
| 1975-09-18 | vs MON | 153 | L 0-5 | 79-74 | 3 | 6,392 | Ron Reed | Steve Renko | Steve Renko | Ron Reed | | 628 | 644 | -16 |
| 1975-09-19 | @ PIT | 154 | L 1-7 | 79-75 | 3 | 19,671 | John Denny | Ken Brett | Ken Brett | John Denny | | 629 | 651 | -22 |
| 1975-09-20 | @ PIT | 155 | W 8-2 | 80-75 | 3 | 13,493 | Eric Rasmussen | Jim Rooker | Eric Rasmussen | Jim Rooker | Al Hrabosky | 637 | 653 | -16 |
| 1975-09-21 | @ PIT | 156 | L 3-5 | 80-76 | 3 | 35,648 | Bob Forsch | Jerry Reuss | Jerry Reuss | Mike Garman | Kent Tekulve | 640 | 658 | -18 |
| 1975-09-22 | @ MON | 157 | W 6-4 | 81-77 | 3 | 0 | Lynn McGlothen | Dan Warthen | Al Hrabosky | Woodie Fryman | | 646 | 662 | -16 |
| 1975-09-22 | @ MON | 158 | L 5-8 | 81-77 | 3 | 6,123 | Ron Reed | Steve Renko | Fred Scherman | Ron Reed | | 651 | 670 | -19 |
| 1975-09-23 | @ MON | 159 | L 0-7 | 81-78 | 4 | 5,520 | John Denny | Steve Rogers | Steve Rogers | John Denny | | 651 | 677 | -26 |
| 1975-09-24 | @ MON | 160 | L 2-6 | 81-79 | 4 | 9,356 | Eric Rasmussen | Don Carrithers | Don Carrithers | Eric Rasmussen | | 653 | 683 | -30 |
| 1975-09-26 | vs PIT | 161 | W 1-0 | 82-79 | 3 | 23,496 | Bob Forsch | Jim Rooker | Bob Forsch | Jim Rooker | | 654 | 683 | -29 |
| 1975-09-27 | vs PIT | 162 | L 2-4 | 82-80 | 3 | 19,180 | Lynn McGlothen | Jerry Reuss | Jerry Reuss | Lynn McGlothen | Kent Tekulve | 656 | 687 | -31 |
| 1975-09-28 | vs PIT | 163 | W 6-2 | 83-80 | 3 | 20,909 | Ron Reed | John Candelaria | Ron Reed | John Candelaria | | 662 | 689 | -27 |