| 1975-04-10 | @ SDN | 1 | W 2-0 | 1-0 | 2 | 17,670 | Jim Barr | Randy Jones | Jim Barr | Rich Folkers | | 2 | 0 | 2 |
| 1975-04-11 | vs ATL | 2 | L 2-4 | 1-1 | 5 | 17,649 | Mike Caldwell | Buzz Capra | Buzz Capra | Mike Caldwell | | 4 | 4 | 0 |
| 1975-04-12 | vs ATL | 3 | L 4-7 | 1-2 | 5 | 4,863 | John D'Acquisto | Carl Morton | Carl Morton | John D'Acquisto | | 8 | 11 | -3 |
| 1975-04-13 | vs ATL | 4 | W 5-0 | 3-2 | 2 | 0 | John Montefusco | Ron Reed | John Montefusco | Ron Reed | | 13 | 11 | 2 |
| 1975-04-13 | vs ATL | 5 | W 4-2 | 3-2 | 2 | 10,527 | Pete Falcone | Gary Gentry | Pete Falcone | Tom House | Randy Moffitt | 17 | 13 | 4 |
| 1975-04-14 | vs SDN | 6 | L 1-3 | 3-3 | 4 | 987 | Jim Barr | Sonny Siebert | Sonny Siebert | Jim Barr | Bill Greif | 18 | 16 | 2 |
| 1975-04-15 | vs SDN | 7 | L 1-2 | 3-4 | 6 | 1,965 | Mike Caldwell | Randy Jones | Randy Jones | Mike Caldwell | Danny Frisella | 19 | 18 | 1 |
| 1975-04-16 | vs SDN | 8 | W 7-1 | 4-4 | 4 | 1,343 | John D'Acquisto | Dan Spillner | John D'Acquisto | Dan Spillner | | 26 | 19 | 7 |
| 1975-04-18 | @ LAN | 9 | W 3-1 | 5-4 | 2 | 53,060 | John Montefusco | Doug Rau | John Montefusco | Doug Rau | | 29 | 20 | 9 |
| 1975-04-19 | @ LAN | 10 | L 2-3 | 5-5 | 5 | 47,053 | Pete Falcone | Don Sutton | Don Sutton | Pete Falcone | Charlie Hough | 31 | 23 | 8 |
| 1975-04-20 | @ LAN | 11 | W 6-3 | 6-5 | 2 | 47,595 | Jim Barr | Rick Rhoden | Randy Moffitt | Geoff Zahn | | 37 | 26 | 11 |
| 1975-04-21 | @ CIN | 12 | W 4-3 | 7-5 | 2 | 12,397 | Mike Caldwell | Fred Norman | Gary Lavelle | Pedro Borbon | | 41 | 29 | 12 |
| 1975-04-22 | @ CIN | 13 | L 4-5 | 7-6 | 2 | 14,235 | John D'Acquisto | Gary Nolan | Clay Kirby | Charlie Williams | | 45 | 34 | 11 |
| 1975-04-23 | @ HOU | 14 | L 2-3 | 8-7 | 3 | 0 | John Montefusco | Doug Konieczny | Doug Konieczny | John Montefusco | Ken Forsch | 47 | 37 | 10 |
| 1975-04-23 | @ HOU | 15 | W 3-0 | 8-7 | 3 | 9,413 | Pete Falcone | Dave Roberts | Pete Falcone | Dave Roberts | | 50 | 37 | 13 |
| 1975-04-24 | @ HOU | 16 | W 6-5 | 9-7 | 2 | 5,960 | Jim Barr | J.R. Richard | Gary Lavelle | Ken Forsch | Dave Heaverlo | 56 | 42 | 14 |
| 1975-04-25 | vs LAN | 17 | L 5-6 | 9-8 | 3 | 14,153 | Mike Caldwell | Andy Messersmith | Andy Messersmith | Mike Caldwell | Jim Brewer | 61 | 48 | 13 |
| 1975-04-26 | vs LAN | 18 | L 3-13 | 9-9 | 5 | 11,304 | John D'Acquisto | Doug Rau | Doug Rau | John D'Acquisto | | 64 | 61 | 3 |
| 1975-04-27 | vs LAN | 19 | L 3-7 | 9-10 | 5 | 35,517 | John Montefusco | Don Sutton | Don Sutton | John Montefusco | | 67 | 68 | -1 |
| 1975-04-29 | vs CIN | 20 | W 4-3 | 10-10 | 5 | 4,609 | Pete Falcone | Don Gullett | Randy Moffitt | Clay Carroll | | 71 | 71 | 0 |
| 1975-04-30 | vs CIN | 21 | L 1-4 | 10-11 | 5 | 4,340 | Jim Barr | Jack Billingham | Jack Billingham | Jim Barr | Will McEnaney | 72 | 75 | -3 |
| 1975-05-02 | vs HOU | 22 | W 5-4 | 11-11 | 4 | 4,110 | Mike Caldwell | Doug Konieczny | Randy Moffitt | Jim York | | 77 | 79 | -2 |
| 1975-05-04 | vs HOU | 23 | W 8-6 | 12-12 | 4 | 0 | John Montefusco | Dave Roberts | Jim Barr | Jim York | | 85 | 85 | 0 |
| 1975-05-04 | vs HOU | 24 | L 8-12 | 12-12 | 4 | 9,451 | John D'Acquisto | J.R. Richard | J.R. Richard | John D'Acquisto | Wayne Granger | 93 | 97 | -4 |
| 1975-05-06 | @ ATL | 25 | W 7-1 | 13-12 | 3 | 5,102 | Pete Falcone | Buzz Capra | Pete Falcone | Buzz Capra | | 100 | 98 | 2 |
| 1975-05-07 | @ ATL | 26 | W 6-2 | 14-12 | 3 | 2,687 | Jim Barr | Carl Morton | Jim Barr | Carl Morton | | 106 | 100 | 6 |
| 1975-05-08 | @ ATL | 27 | L 2-3 | 14-13 | 3 | 3,656 | Mike Caldwell | Ron Reed | Ron Reed | Mike Caldwell | Tom House | 108 | 103 | 5 |
| 1975-05-09 | @ SLN | 28 | L 4-6 | 14-14 | 3 | 21,410 | John D'Acquisto | Lynn McGlothen | Lynn McGlothen | John D'Acquisto | Al Hrabosky | 112 | 109 | 3 |
| 1975-05-10 | @ SLN | 29 | L 2-9 | 14-15 | 4 | 18,919 | Charlie Williams | John Curtis | John Curtis | Charlie Williams | | 114 | 118 | -4 |
| 1975-05-11 | @ SLN | 30 | L 3-4 | 14-16 | 5 | 10,692 | Pete Falcone | Bob Forsch | Bob Forsch | Pete Falcone | Al Hrabosky | 117 | 122 | -5 |
| 1975-05-12 | @ NYN | 31 | L 2-3 | 14-17 | 5 | 10,836 | Jim Barr | Jon Matlack | Jon Matlack | Jim Barr | Tom Hall | 119 | 125 | -6 |
| 1975-05-14 | @ NYN | 32 | L 1-5 | 14-18 | 5 | 13,586 | Mike Caldwell | Jerry Koosman | Jerry Koosman | Mike Caldwell | | 120 | 130 | -10 |
| 1975-05-16 | vs SLN | 33 | W 4-3 | 15-18 | 5 | 5,764 | John Montefusco | Bob Gibson | Gary Lavelle | Elias Sosa | | 124 | 133 | -9 |
| 1975-05-17 | vs SLN | 34 | L 2-17 | 15-19 | 5 | 6,891 | Pete Falcone | Bob Forsch | Bob Forsch | Pete Falcone | | 126 | 150 | -24 |
| 1975-05-18 | vs SLN | 35 | W 2-0 | 16-19 | 5 | 11,332 | Jim Barr | Lynn McGlothen | Jim Barr | Lynn McGlothen | | 128 | 150 | -22 |
| 1975-05-19 | vs PIT | 36 | W 6-4 | 17-19 | 5 | 1,795 | Mike Caldwell | Jerry Reuss | Mike Caldwell | Jerry Reuss | | 134 | 154 | -20 |
| 1975-05-20 | vs PIT | 37 | W 12-4 | 18-19 | 5 | 1,759 | Ed Halicki | Dock Ellis | Ed Halicki | Dock Ellis | | 146 | 158 | -12 |
| 1975-05-21 | vs PIT | 38 | W 2-1 | 19-19 | 5 | 3,513 | John Montefusco | Bruce Kison | Jim Barr | Dave Giusti | | 148 | 159 | -11 |
| 1975-05-23 | vs CHN | 39 | W 3-2 | 20-19 | 3 | 2,675 | Pete Falcone | Rick Reuschel | Pete Falcone | Rick Reuschel | Gary Lavelle | 151 | 161 | -10 |
| 1975-05-24 | vs CHN | 40 | W 10-3 | 21-19 | 3 | 6,655 | Jim Barr | Bill Bonham | Jim Barr | Bill Bonham | | 161 | 164 | -3 |
| 1975-05-25 | vs CHN | 41 | W 9-7 | 22-19 | 3 | 12,341 | Mike Caldwell | Geoff Zahn | Charlie Williams | Ken Frailing | Gary Lavelle | 170 | 171 | -1 |
| 1975-05-26 | @ PHI | 42 | L 0-1 | 22-20 | 3 | 15,693 | Ed Halicki | Wayne Twitchell | Tug McGraw | Ed Halicki | | 170 | 172 | -2 |
| 1975-05-27 | @ PHI | 43 | W 1-0 | 23-20 | 3 | 18,735 | John Montefusco | Tom Underwood | John Montefusco | Gene Garber | | 171 | 172 | -1 |
| 1975-05-28 | @ PHI | 44 | L 6-8 | 23-21 | 3 | 15,706 | Pete Falcone | Steve Carlton | Steve Carlton | Pete Falcone | Tug McGraw | 177 | 180 | -3 |
| 1975-05-31 | @ MON | 45 | L 2-3 | 23-22 | 3 | 11,492 | Jim Barr | Steve Rogers | Dan Warthen | Gary Lavelle | | 179 | 183 | -4 |
| 1975-06-01 | @ MON | 46 | W 13-5 | 24-22 | 3 | 12,710 | Mike Caldwell | Dave McNally | Mike Caldwell | Dan Warthen | Randy Moffitt | 192 | 188 | 4 |
| 1975-06-03 | @ CHN | 47 | L 5-6 | 24-23 | 3 | 11,082 | Ed Halicki | Ray Burris | Geoff Zahn | Randy Moffitt | | 197 | 194 | 3 |
| 1975-06-04 | @ CHN | 48 | W 10-8 | 25-23 | 3 | 9,126 | John Montefusco | Rick Reuschel | Charlie Williams | Oscar Zamora | Mike Caldwell | 207 | 202 | 5 |
| 1975-06-05 | @ CHN | 49 | L 4-8 | 25-24 | 3 | 13,211 | Pete Falcone | Steve Stone | Darold Knowles | Randy Moffitt | | 211 | 210 | 1 |
| 1975-06-06 | @ PIT | 50 | L 2-7 | 25-25 | 3 | 11,923 | Jim Barr | Bruce Kison | Bruce Kison | Jim Barr | | 213 | 217 | -4 |
| 1975-06-07 | @ PIT | 51 | L 6-7 | 25-26 | 3 | 8,668 | Mike Caldwell | Jim Rooker | Ramon Hernandez | Tommy Toms | Dave Giusti | 219 | 224 | -5 |
| 1975-06-08 | @ PIT | 52 | W 3-1 | 27-26 | 3 | 0 | Ed Halicki | John Candelaria | Ed Halicki | John Candelaria | | 222 | 225 | -3 |
| 1975-06-08 | @ PIT | 53 | W 4-2 | 27-26 | 3 | 24,128 | Charlie Williams | Larry Demery | Gary Lavelle | Larry Demery | Randy Moffitt | 226 | 227 | -1 |
| 1975-06-09 | vs NYN | 54 | W 5-4 | 28-26 | 3 | 4,644 | John Montefusco | Jerry Koosman | Dave Heaverlo | Jerry Koosman | | 231 | 231 | 0 |
| 1975-06-10 | vs NYN | 55 | L 0-5 | 28-27 | 3 | 6,151 | Jim Barr | Tom Seaver | Tom Seaver | Jim Barr | | 231 | 236 | -5 |
| 1975-06-11 | vs PHI | 56 | W 8-3 | 29-27 | 3 | 3,472 | Mike Caldwell | Tom Underwood | Mike Caldwell | Tom Underwood | | 239 | 239 | 0 |
| 1975-06-12 | vs PHI | 57 | L 1-4 | 29-28 | 3 | 3,869 | Ed Halicki | Steve Carlton | Steve Carlton | Ed Halicki | | 240 | 243 | -3 |
| 1975-06-13 | vs MON | 58 | L 2-4 | 29-29 | 3 | 3,230 | Pete Falcone | Fred Scherman | Dan Warthen | Pete Falcone | | 242 | 247 | -5 |
| 1975-06-14 | vs MON | 59 | L 1-3 | 29-30 | 3 | 4,890 | John Montefusco | Woodie Fryman | Woodie Fryman | John Montefusco | | 243 | 250 | -7 |
| 1975-06-15 | vs MON | 60 | L 1-2 | 29-32 | 4 | 0 | Jim Barr | Steve Renko | Steve Renko | Jim Barr | Dan Warthen | 244 | 252 | -8 |
| 1975-06-15 | vs MON | 61 | L 2-5 | 29-32 | 4 | 12,131 | Mike Caldwell | Dennis Blair | Dennis Blair | Mike Caldwell | Don DeMola | 246 | 257 | -11 |
| 1975-06-16 | vs SDN | 62 | L 1-7 | 29-33 | 4 | 1,851 | Ed Halicki | Rich Folkers | Rich Folkers | Ed Halicki | | 247 | 264 | -17 |
| 1975-06-17 | vs SDN | 63 | W 3-1 | 30-33 | 4 | 2,482 | Pete Falcone | Dave Freisleben | Pete Falcone | Dave Freisleben | | 250 | 265 | -15 |
| 1975-06-18 | vs SDN | 64 | W 8-1 | 31-33 | 3 | 3,114 | John Montefusco | Joe McIntosh | John Montefusco | Joe McIntosh | | 258 | 266 | -8 |
| 1975-06-20 | @ ATL | 65 | L 2-4 | 31-34 | 3 | 4,373 | Jim Barr | Phil Niekro | Phil Niekro | Jim Barr | Tom House | 260 | 270 | -10 |
| 1975-06-21 | @ ATL | 66 | W 4-3 | 32-34 | 3 | 10,084 | Mike Caldwell | Carl Morton | Mike Caldwell | Carl Morton | Randy Moffitt | 264 | 273 | -9 |
| 1975-06-22 | @ ATL | 67 | L 2-8 | 33-35 | 3 | 0 | Ed Halicki | Mike Thompson | Mike Beard | Ed Halicki | | 266 | 281 | -15 |
| 1975-06-22 | @ ATL | 68 | W 5-2 | 33-35 | 3 | 12,410 | Pete Falcone | Blue Moon Odom | Pete Falcone | Blue Moon Odom | Gary Lavelle | 271 | 283 | -12 |
| 1975-06-23 | @ SDN | 69 | L 6-7 | 33-36 | 3 | 6,999 | John Montefusco | Joe McIntosh | Dave Tomlin | Gary Lavelle | Bill Greif | 277 | 290 | -13 |
| 1975-06-24 | @ SDN | 70 | L 1-2 | 33-38 | 4 | 0 | Jim Barr | Randy Jones | Randy Jones | Gary Lavelle | | 278 | 292 | -14 |
| 1975-06-24 | @ SDN | 71 | L 0-3 | 33-38 | 4 | 19,817 | Tom Bradley | Brent Strom | Brent Strom | Tom Bradley | | 278 | 295 | -17 |
| 1975-06-25 | @ SDN | 72 | L 2-6 | 33-39 | 4 | 11,734 | Mike Caldwell | Rich Folkers | Rich Folkers | Mike Caldwell | | 280 | 301 | -21 |
| 1975-06-26 | vs LAN | 73 | W 2-0 | 34-39 | 4 | 6,989 | Ed Halicki | Andy Messersmith | Ed Halicki | Andy Messersmith | | 282 | 301 | -19 |
| 1975-06-27 | vs LAN | 74 | W 10-5 | 35-39 | 4 | 12,387 | Pete Falcone | Burt Hooton | Charlie Williams | Burt Hooton | Randy Moffitt | 292 | 306 | -14 |
| 1975-06-28 | vs LAN | 75 | W 2-1 | 36-39 | 3 | 13,022 | John Montefusco | Doug Rau | John Montefusco | Doug Rau | Randy Moffitt | 294 | 307 | -13 |
| 1975-06-29 | vs LAN | 76 | W 5-2 | 37-39 | 3 | 25,929 | Tom Bradley | Don Sutton | Tom Bradley | Don Sutton | Randy Moffitt | 299 | 309 | -10 |
| 1975-07-01 | vs ATL | 77 | W 9-1 | 38-39 | 3 | 2,796 | Mike Caldwell | Jamie Easterly | Mike Caldwell | Jamie Easterly | | 308 | 310 | -2 |
| 1975-07-02 | vs ATL | 78 | L 0-6 | 38-40 | 3 | 5,253 | Ed Halicki | Phil Niekro | Phil Niekro | Ed Halicki | | 308 | 316 | -8 |
| 1975-07-03 | @ LAN | 79 | L 1-7 | 38-41 | 3 | 35,929 | Pete Falcone | Don Sutton | Don Sutton | Pete Falcone | | 309 | 323 | -14 |
| 1975-07-04 | @ LAN | 80 | W 1-0 | 39-41 | 3 | 52,621 | John Montefusco | Andy Messersmith | John Montefusco | Andy Messersmith | | 310 | 323 | -13 |
| 1975-07-05 | @ LAN | 81 | L 4-5 | 39-42 | 3 | 36,200 | Jim Barr | Burt Hooton | Al Downing | Ed Halicki | Mike Marshall | 314 | 328 | -14 |
| 1975-07-06 | @ LAN | 82 | L 1-5 | 39-43 | 3 | 33,235 | Tom Bradley | Doug Rau | Doug Rau | Tom Bradley | | 315 | 333 | -18 |
| 1975-07-07 | @ SLN | 83 | L 6-8 | 39-44 | 3 | 15,498 | Mike Caldwell | Ron Reed | Ron Reed | Mike Caldwell | Al Hrabosky | 321 | 341 | -20 |
| 1975-07-08 | @ SLN | 84 | W 6-4 | 40-44 | 3 | 15,926 | Pete Falcone | Bob Gibson | Pete Falcone | Bob Gibson | Gary Lavelle | 327 | 345 | -18 |
| 1975-07-09 | @ SLN | 85 | L 0-9 | 40-45 | 4 | 14,762 | John Montefusco | John Denny | John Denny | John Montefusco | | 327 | 354 | -27 |
| 1975-07-11 | @ CHN | 86 | L 6-8 | 40-46 | 3 | 13,415 | Ed Halicki | Bill Bonham | Tom Dettore | Randy Moffitt | Darold Knowles | 333 | 362 | -29 |
| 1975-07-12 | @ CHN | 87 | L 4-6 | 40-47 | 3 | 17,155 | Mike Caldwell | Steve Stone | Steve Stone | Mike Caldwell | | 337 | 368 | -31 |
| 1975-07-13 | @ CHN | 88 | W 4-1 | 41-47 | 3 | 22,868 | John Montefusco | Geoff Zahn | John Montefusco | Geoff Zahn | Charlie Williams | 341 | 369 | -28 |
| 1975-07-17 | vs SLN | 89 | L 0-1 | 41-48 | 3 | 3,085 | Jim Barr | John Denny | Al Hrabosky | Jim Barr | | 341 | 370 | -29 |
| 1975-07-18 | vs SLN | 90 | W 2-1 | 42-48 | 3 | 3,291 | Pete Falcone | Bob Forsch | Gary Lavelle | Greg Terlecky | | 343 | 371 | -28 |
| 1975-07-19 | vs SLN | 91 | W 5-2 | 43-48 | 3 | 7,136 | John Montefusco | Lynn McGlothen | John Montefusco | Lynn McGlothen | | 348 | 373 | -25 |
| 1975-07-20 | vs PIT | 92 | W 2-1 | 44-49 | 3 | 0 | Ed Halicki | Jim Rooker | Ed Halicki | Jim Rooker | | 350 | 374 | -24 |
| 1975-07-20 | vs PIT | 93 | L 1-7 | 44-49 | 3 | 14,723 | Mike Caldwell | Ken Brett | Ken Brett | Mike Caldwell | | 351 | 381 | -30 |
| 1975-07-21 | vs PIT | 94 | W 7-2 | 45-49 | 3 | 3,417 | Jim Barr | John Candelaria | Jim Barr | John Candelaria | | 358 | 383 | -25 |
| 1975-07-22 | vs CHN | 95 | W 9-5 | 46-49 | 3 | 3,639 | Pete Falcone | Ray Burris | Charlie Williams | Ray Burris | Randy Moffitt | 367 | 388 | -21 |
| 1975-07-23 | vs CHN | 96 | W 10-2 | 47-49 | 3 | 6,526 | John Montefusco | Steve Stone | John Montefusco | Steve Stone | | 377 | 390 | -13 |
| 1975-07-24 | vs CHN | 97 | L 3-4 | 47-50 | 3 | 5,501 | Ed Halicki | Bill Bonham | Bill Bonham | Ed Halicki | Oscar Zamora | 380 | 394 | -14 |
| 1975-07-25 | @ HOU | 98 | W 8-1 | 48-50 | 3 | 14,452 | Jim Barr | Dave Roberts | Jim Barr | Dave Roberts | | 388 | 395 | -7 |
| 1975-07-26 | @ HOU | 99 | W 3-2 | 50-50 | 3 | 0 | Pete Falcone | Ken Forsch | Randy Moffitt | Ken Forsch | Gary Lavelle | 391 | 397 | -6 |
| 1975-07-26 | @ HOU | 100 | W 9-3 | 50-50 | 3 | 24,736 | Tom Bradley | Doug Konieczny | Tom Bradley | Doug Konieczny | Charlie Williams | 400 | 400 | 0 |
| 1975-07-27 | @ HOU | 101 | W 3-1 | 51-50 | 3 | 10,117 | John Montefusco | J.R. Richard | John Montefusco | J.R. Richard | Gary Lavelle | 403 | 401 | 2 |
| 1975-07-28 | @ CIN | 102 | L 4-8 | 51-51 | 3 | 28,044 | Ed Halicki | Gary Nolan | Pedro Borbon | Ed Halicki | | 407 | 409 | -2 |
| 1975-07-29 | @ CIN | 103 | W 4-2 | 52-51 | 3 | 28,637 | Jim Barr | Fred Norman | Jim Barr | Rawly Eastwick | | 411 | 411 | 0 |
| 1975-07-30 | @ CIN | 104 | L 1-6 | 52-52 | 3 | 28,658 | Pete Falcone | Pat Darcy | Pat Darcy | Pete Falcone | | 412 | 417 | -5 |
| 1975-07-31 | @ CIN | 105 | L 6-11 | 52-53 | 3 | 31,620 | John Montefusco | Clay Kirby | Clay Kirby | John Montefusco | Clay Carroll | 418 | 428 | -10 |
| 1975-08-01 | vs HOU | 106 | W 3-2 | 53-53 | 3 | 2,653 | Ed Halicki | J.R. Richard | Ed Halicki | J.R. Richard | | 421 | 430 | -9 |
| 1975-08-02 | vs HOU | 107 | W 8-7 | 54-53 | 3 | 5,339 | Jim Barr | Larry Dierker | Dave Heaverlo | Jim Crawford | | 429 | 437 | -8 |
| 1975-08-03 | vs HOU | 108 | W 5-4 | 55-54 | 3 | 0 | Pete Falcone | Dave Roberts | Pete Falcone | Dave Roberts | Randy Moffitt | 434 | 441 | -7 |
| 1975-08-03 | vs HOU | 109 | L 9-10 | 55-54 | 3 | 12,450 | Tom Bradley | Doug Konieczny | Jim Crawford | Mike Caldwell | Mike Cosgrove | 443 | 451 | -8 |
| 1975-08-04 | vs CIN | 110 | L 5-7 | 55-55 | 3 | 13,561 | John Montefusco | Fred Norman | Clay Carroll | Mike Caldwell | Rawly Eastwick | 448 | 458 | -10 |
| 1975-08-05 | vs CIN | 111 | L 3-6 | 55-56 | 3 | 8,812 | Ed Halicki | Clay Kirby | Pedro Borbon | Ed Halicki | Will McEnaney | 451 | 464 | -13 |
| 1975-08-06 | vs CIN | 112 | L 5-12 | 55-57 | 3 | 14,389 | Jim Barr | Jack Billingham | Jack Billingham | Jim Barr | | 456 | 476 | -20 |
| 1975-08-08 | @ PHI | 113 | L 4-5 | 55-58 | 3 | 31,026 | Pete Falcone | Tom Underwood | Gene Garber | Randy Moffitt | | 460 | 481 | -21 |
| 1975-08-09 | @ PHI | 114 | L 4-11 | 55-59 | 3 | 43,504 | John Montefusco | Steve Carlton | Steve Carlton | John Montefusco | | 464 | 492 | -28 |
| 1975-08-10 | @ PHI | 115 | W 8-1 | 56-59 | 3 | 35,405 | Jim Barr | Dick Ruthven | Jim Barr | Dick Ruthven | | 472 | 493 | -21 |
| 1975-08-11 | @ MON | 116 | W 9-2 | 57-59 | 3 | 14,614 | Ed Halicki | Steve Rogers | Ed Halicki | Steve Rogers | | 481 | 495 | -14 |
| 1975-08-12 | @ MON | 117 | W 5-2 | 58-59 | 3 | 16,254 | Pete Falcone | Steve Renko | Mike Caldwell | Dale Murray | | 486 | 497 | -11 |
| 1975-08-13 | @ MON | 118 | W 4-3 | 59-59 | 3 | 14,148 | John Montefusco | Dan Warthen | Charlie Williams | Woodie Fryman | | 490 | 500 | -10 |
| 1975-08-14 | @ MON | 119 | W 9-2 | 60-59 | 3 | 8,184 | Jim Barr | Dennis Blair | Jim Barr | Dennis Blair | | 499 | 502 | -3 |
| 1975-08-15 | @ NYN | 120 | W 6-2 | 61-60 | 3 | 0 | Ed Halicki | Jerry Koosman | Ed Halicki | Jerry Koosman | Gary Lavelle | 505 | 504 | 1 |
| 1975-08-15 | @ NYN | 121 | L 4-9 | 61-60 | 3 | 43,395 | Tom Bradley | Hank Webb | Hank Webb | Tom Bradley | | 509 | 513 | -4 |
| 1975-08-16 | @ NYN | 122 | L 2-4 | 61-61 | 3 | 20,751 | Pete Falcone | Craig Swan | Craig Swan | Pete Falcone | Bob Apodaca | 511 | 517 | -6 |
| 1975-08-17 | @ NYN | 123 | L 0-3 | 61-62 | 3 | 30,953 | John Montefusco | Tom Seaver | Tom Seaver | John Montefusco | Jerry Koosman | 511 | 520 | -9 |
| 1975-08-19 | @ PIT | 124 | L 0-4 | 61-63 | 3 | 22,609 | Jim Barr | Jerry Reuss | Jerry Reuss | Jim Barr | | 511 | 524 | -13 |
| 1975-08-20 | @ PIT | 125 | L 1-3 | 61-64 | 3 | 14,033 | Ed Halicki | Jim Rooker | Jim Rooker | Ed Halicki | Dave Giusti | 512 | 527 | -15 |
| 1975-08-22 | vs NYN | 126 | L 4-6 | 61-65 | 3 | 4,428 | Pete Falcone | Tom Seaver | Tom Seaver | Pete Falcone | Bob Apodaca | 516 | 533 | -17 |
| 1975-08-23 | vs NYN | 127 | W 2-1 | 62-65 | 3 | 8,060 | John Montefusco | Jerry Koosman | Gary Lavelle | Skip Lockwood | | 518 | 534 | -16 |
| 1975-08-24 | vs NYN | 128 | L 5-9 | 63-66 | 3 | 0 | Jim Barr | Jon Matlack | Jon Matlack | Jim Barr | Bob Apodaca | 523 | 543 | -20 |
| 1975-08-24 | vs NYN | 129 | W 6-0 | 63-66 | 3 | 24,132 | Ed Halicki | Craig Swan | Ed Halicki | Craig Swan | | 529 | 543 | -14 |
| 1975-08-26 | vs MON | 130 | W 4-3 | 64-66 | 3 | 1,795 | Pete Falcone | Dan Warthen | Pete Falcone | Dan Warthen | | 533 | 546 | -13 |
| 1975-08-27 | vs MON | 131 | W 9-1 | 65-66 | 3 | 2,594 | John Montefusco | Woodie Fryman | John Montefusco | Woodie Fryman | | 542 | 547 | -5 |
| 1975-08-28 | vs PHI | 132 | L 5-8 | 65-67 | 3 | 4,190 | Jim Barr | Jim Lonborg | Tom Hilgendorf | Jim Barr | | 547 | 555 | -8 |
| 1975-08-29 | vs PHI | 133 | L 1-3 | 65-68 | 3 | 5,007 | Ed Halicki | Larry Christenson | Larry Christenson | Ed Halicki | Tug McGraw | 548 | 558 | -10 |
| 1975-08-30 | vs PHI | 134 | W 4-1 | 66-68 | 3 | 5,663 | Pete Falcone | Tom Underwood | Pete Falcone | Tom Underwood | | 552 | 559 | -7 |
| 1975-08-31 | vs PHI | 135 | W 5-4 | 67-68 | 3 | 8,884 | John Montefusco | Steve Carlton | John Montefusco | Steve Carlton | Charlie Williams | 557 | 563 | -6 |
| 1975-09-01 | vs LAN | 136 | L 1-3 | 67-69 | 3 | 9,996 | Jim Barr | Burt Hooton | Burt Hooton | Charlie Williams | | 558 | 566 | -8 |
| 1975-09-02 | vs LAN | 137 | W 7-3 | 68-69 | 3 | 5,098 | Ed Halicki | Don Sutton | Ed Halicki | Don Sutton | | 565 | 569 | -4 |
| 1975-09-03 | @ HOU | 138 | W 9-4 | 69-69 | 3 | 4,437 | Pete Falcone | J.R. Richard | Pete Falcone | J.R. Richard | | 574 | 573 | 1 |
| 1975-09-04 | @ HOU | 139 | W 2-1 | 70-69 | 3 | 4,323 | John Montefusco | Larry Dierker | John Montefusco | Larry Dierker | Randy Moffitt | 576 | 574 | 2 |
| 1975-09-05 | @ CIN | 140 | L 3-4 | 70-70 | 3 | 24,022 | Jim Barr | Fred Norman | Rawly Eastwick | Dave Heaverlo | | 579 | 578 | 1 |
| 1975-09-06 | @ CIN | 141 | L 2-3 | 70-71 | 3 | 37,015 | Ed Halicki | Jack Billingham | Jack Billingham | Ed Halicki | Will McEnaney | 581 | 581 | 0 |
| 1975-09-07 | @ CIN | 142 | L 4-8 | 70-72 | 3 | 34,415 | Pete Falcone | Don Gullett | Don Gullett | Pete Falcone | | 585 | 589 | -4 |
| 1975-09-08 | @ LAN | 143 | L 0-4 | 70-73 | 3 | 17,239 | John Montefusco | Andy Messersmith | Andy Messersmith | John Montefusco | | 585 | 593 | -8 |
| 1975-09-09 | @ LAN | 144 | L 3-8 | 70-74 | 3 | 14,344 | Jim Barr | Doug Rau | Charlie Hough | Jim Barr | | 588 | 601 | -13 |
| 1975-09-10 | vs HOU | 145 | L 3-6 | 70-75 | 3 | 1,016 | Ed Halicki | Mike Cosgrove | Mike Cosgrove | Ed Halicki | | 591 | 607 | -16 |
| 1975-09-11 | vs HOU | 146 | L 3-4 | 70-76 | 3 | 1,149 | Pete Falcone | Jose Sosa | Joe Niekro | Randy Moffitt | Jim Crawford | 594 | 611 | -17 |
| 1975-09-12 | vs CIN | 147 | L 3-6 | 70-77 | 3 | 5,614 | John Montefusco | Fred Norman | Fred Norman | John Montefusco | Rawly Eastwick | 597 | 617 | -20 |
| 1975-09-13 | vs CIN | 148 | W 9-2 | 71-77 | 3 | 5,453 | Jim Barr | Don Gullett | Jim Barr | Don Gullett | | 606 | 619 | -13 |
| 1975-09-14 | vs CIN | 149 | W 4-2 | 72-78 | 3 | 0 | Rob Dressler | Gary Nolan | Dave Heaverlo | Gary Nolan | | 610 | 621 | -11 |
| 1975-09-14 | vs CIN | 150 | L 3-8 | 72-78 | 3 | 16,997 | Greg Minton | Pat Darcy | Pat Darcy | Greg Minton | | 613 | 629 | -16 |
| 1975-09-15 | vs ATL | 151 | L 0-12 | 72-79 | 3 | 851 | Pete Falcone | Jamie Easterly | Jamie Easterly | Pete Falcone | | 613 | 641 | -28 |
| 1975-09-16 | vs ATL | 152 | W 7-6 | 73-79 | 3 | 1,089 | John Montefusco | Mike Beard | John D'Acquisto | Tom House | | 620 | 647 | -27 |
| 1975-09-17 | vs ATL | 153 | W 4-1 | 74-79 | 3 | 1,141 | Jim Barr | Phil Niekro | Jim Barr | Phil Niekro | | 624 | 648 | -24 |
| 1975-09-19 | vs SDN | 154 | W 3-1 | 75-79 | 3 | 1,718 | Mike Caldwell | Randy Jones | Mike Caldwell | Randy Jones | | 627 | 649 | -22 |
| 1975-09-20 | vs SDN | 155 | W 4-2 | 76-79 | 3 | 2,305 | Pete Falcone | Rich Folkers | Pete Falcone | Rich Folkers | Randy Moffitt | 631 | 651 | -20 |
| 1975-09-21 | vs SDN | 156 | W 2-1 | 77-79 | 3 | 15,447 | John Montefusco | Brent Strom | John Montefusco | Brent Strom | | 633 | 652 | -19 |
| 1975-09-24 | @ ATL | 157 | L 6-7 | 77-80 | 3 | 1,045 | Jim Barr | Carl Morton | Elias Sosa | Jim Barr | | 639 | 659 | -20 |
| 1975-09-25 | @ SDN | 158 | L 6-8 | 77-81 | 3 | 3,886 | Mike Caldwell | Bill Greif | Dave Tomlin | Mike Caldwell | Danny Frisella | 645 | 667 | -22 |
| 1975-09-26 | @ SDN | 159 | W 5-0 | 78-81 | 3 | 7,488 | John Montefusco | Brent Strom | John Montefusco | Brent Strom | | 650 | 667 | -17 |
| 1975-09-27 | @ SDN | 160 | W 4-1 | 79-81 | 3 | 27,655 | Rob Dressler | Joe McIntosh | Rob Dressler | Joe McIntosh | | 654 | 668 | -14 |
| 1975-09-28 | @ SDN | 161 | W 5-3 | 80-81 | 3 | 15,069 | Greg Minton | Randy Jones | Greg Minton | Randy Jones | Gary Lavelle | 659 | 671 | -12 |