| 1975-04-10 | vs SFN | 1 | L 0-2 | 0-1 | 6 | 17,670 | Randy Jones | Jim Barr | Jim Barr | Rich Folkers | | 0 | 2 | -2 |
| 1975-04-11 | vs CIN | 2 | W 5-2 | 1-1 | 4 | 13,818 | Dan Spillner | Fred Norman | Dan Spillner | Fred Norman | | 5 | 4 | 1 |
| 1975-04-12 | vs CIN | 3 | W 3-2 | 2-1 | 1 | 17,881 | Joe McIntosh | Gary Nolan | Joe McIntosh | Gary Nolan | Bill Greif | 8 | 6 | 2 |
| 1975-04-13 | vs CIN | 4 | L 0-10 | 2-2 | 4 | 17,622 | Dave Freisleben | Don Gullett | Don Gullett | Dave Freisleben | | 8 | 16 | -8 |
| 1975-04-14 | @ SFN | 5 | W 3-1 | 3-2 | 1 | 987 | Sonny Siebert | Jim Barr | Sonny Siebert | Jim Barr | Bill Greif | 11 | 17 | -6 |
| 1975-04-15 | @ SFN | 6 | W 2-1 | 4-2 | 1 | 1,965 | Randy Jones | Mike Caldwell | Randy Jones | Mike Caldwell | Danny Frisella | 13 | 18 | -5 |
| 1975-04-16 | @ SFN | 7 | L 1-7 | 4-3 | 1 | 1,343 | Dan Spillner | John D'Acquisto | John D'Acquisto | Dan Spillner | | 14 | 25 | -11 |
| 1975-04-18 | @ ATL | 8 | W 3-1 | 5-3 | 1 | 5,954 | Joe McIntosh | Ron Reed | Joe McIntosh | Ron Reed | Dave Tomlin | 17 | 26 | -9 |
| 1975-04-19 | @ ATL | 9 | W 8-2 | 6-3 | 1 | 4,714 | Dave Freisleben | Gary Gentry | Dave Freisleben | Gary Gentry | | 25 | 28 | -3 |
| 1975-04-20 | @ ATL | 10 | L 3-4 | 6-4 | 1 | 7,204 | Sonny Siebert | Phil Niekro | Tom House | Rich Folkers | | 28 | 32 | -4 |
| 1975-04-21 | @ HOU | 11 | W 4-0 | 7-4 | 1 | 6,523 | Randy Jones | Jim Crawford | Randy Jones | Jim Crawford | | 32 | 32 | 0 |
| 1975-04-22 | @ HOU | 12 | W 2-1 | 8-4 | 1 | 5,300 | Dan Spillner | Tom Griffin | Dan Spillner | Tom Griffin | | 34 | 33 | 1 |
| 1975-04-23 | vs LAN | 13 | W 7-1 | 9-4 | 1 | 43,478 | Joe McIntosh | Don Sutton | Joe McIntosh | Don Sutton | | 41 | 34 | 7 |
| 1975-04-24 | vs LAN | 14 | L 6-11 | 9-5 | 1 | 21,789 | Dave Freisleben | Rick Rhoden | Rick Rhoden | Dave Freisleben | Al Downing | 47 | 45 | 2 |
| 1975-04-25 | vs ATL | 15 | W 5-3 | 10-5 | 1 | 11,033 | Sonny Siebert | Buzz Capra | Sonny Siebert | Buzz Capra | Bill Greif | 52 | 48 | 4 |
| 1975-04-26 | vs ATL | 16 | L 4-6 | 10-6 | 1 | 38,189 | Randy Jones | Carl Morton | Carl Morton | Randy Jones | Tom House | 56 | 54 | 2 |
| 1975-04-27 | vs ATL | 17 | L 8-12 | 10-8 | 3 | 0 | Dan Spillner | Ron Reed | Ron Reed | Rich Folkers | | 64 | 66 | -2 |
| 1975-04-27 | vs ATL | 18 | L 1-4 | 10-8 | 3 | 25,996 | Alan Foster | Roric Harrison | Roric Harrison | Alan Foster | | 65 | 70 | -5 |
| 1975-04-28 | vs HOU | 19 | L 1-4 | 10-9 | 3 | 19,080 | Joe McIntosh | Dave Roberts | Dave Roberts | Joe McIntosh | | 66 | 74 | -8 |
| 1975-04-29 | vs HOU | 20 | L 2-8 | 10-10 | 4 | 7,840 | Dave Freisleben | J.R. Richard | J.R. Richard | Dave Freisleben | | 68 | 82 | -14 |
| 1975-04-30 | vs HOU | 21 | W 4-2 | 11-10 | 2 | 8,077 | Sonny Siebert | Larry Dierker | Sonny Siebert | Larry Dierker | Bill Greif | 72 | 84 | -12 |
| 1975-05-01 | vs HOU | 22 | L 3-6 | 11-11 | 4 | 11,885 | Randy Jones | Ken Forsch | Ken Forsch | Randy Jones | Jim Crawford | 75 | 90 | -15 |
| 1975-05-02 | @ LAN | 23 | L 0-3 | 11-12 | 5 | 53,701 | Dan Spillner | Don Sutton | Don Sutton | Dan Spillner | | 75 | 93 | -18 |
| 1975-05-03 | @ LAN | 24 | W 3-1 | 12-12 | 4 | 48,830 | Joe McIntosh | Andy Messersmith | Alan Foster | Jim Brewer | | 78 | 94 | -16 |
| 1975-05-04 | @ LAN | 25 | W 10-7 | 13-12 | 3 | 42,100 | Dave Freisleben | Rick Rhoden | Randy Jones | Burt Hooton | | 88 | 101 | -13 |
| 1975-05-06 | @ CIN | 26 | L 3-7 | 13-13 | 4 | 11,933 | Sonny Siebert | Jack Billingham | Jack Billingham | Sonny Siebert | | 91 | 108 | -17 |
| 1975-05-07 | @ CIN | 27 | L 2-10 | 13-14 | 4 | 16,931 | Dan Spillner | Fred Norman | Fred Norman | Dan Spillner | Clay Carroll | 93 | 118 | -25 |
| 1975-05-08 | @ CIN | 28 | W 3-0 | 14-14 | 4 | 14,192 | Randy Jones | Gary Nolan | Randy Jones | Gary Nolan | | 96 | 118 | -22 |
| 1975-05-09 | @ CHN | 29 | L 2-5 | 14-15 | 5 | 6,885 | Joe McIntosh | Ray Burris | Ray Burris | Joe McIntosh | Darold Knowles | 98 | 123 | -25 |
| 1975-05-10 | @ CHN | 30 | L 1-5 | 14-16 | 5 | 20,209 | Sonny Siebert | Rick Reuschel | Rick Reuschel | Sonny Siebert | Geoff Zahn | 99 | 128 | -29 |
| 1975-05-11 | @ CHN | 31 | W 2-1 | 15-16 | 4 | 19,145 | Dave Freisleben | Bill Bonham | Dave Freisleben | Bill Bonham | | 101 | 129 | -28 |
| 1975-05-13 | @ PIT | 32 | L 0-2 | 15-17 | 4 | 5,482 | Dan Spillner | Jerry Reuss | Jerry Reuss | Dan Spillner | | 101 | 131 | -30 |
| 1975-05-14 | @ PIT | 33 | L 4-5 | 15-18 | 4 | 8,334 | Randy Jones | Dock Ellis | Sam McDowell | Bill Greif | | 105 | 136 | -31 |
| 1975-05-16 | vs CHN | 34 | W 8-2 | 16-18 | 4 | 11,484 | Joe McIntosh | Bill Bonham | Joe McIntosh | Bill Bonham | | 113 | 138 | -25 |
| 1975-05-17 | vs CHN | 35 | W 4-1 | 17-18 | 4 | 49,599 | Dave Freisleben | Steve Stone | Dave Freisleben | Darold Knowles | | 117 | 139 | -22 |
| 1975-05-18 | vs CHN | 36 | L 2-3 | 17-19 | 4 | 16,051 | Dan Spillner | Ray Burris | Ray Burris | Dan Spillner | Oscar Zamora | 119 | 142 | -23 |
| 1975-05-19 | vs SLN | 37 | W 1-0 | 18-19 | 3 | 10,111 | Randy Jones | John Curtis | Randy Jones | John Curtis | | 120 | 142 | -22 |
| 1975-05-20 | vs SLN | 38 | W 5-2 | 19-19 | 3 | 7,318 | Alan Foster | Elias Sosa | Alan Foster | Elias Sosa | | 125 | 144 | -19 |
| 1975-05-21 | vs SLN | 39 | W 1-0 | 20-19 | 2 | 13,163 | Joe McIntosh | Bob Gibson | Joe McIntosh | Bob Gibson | | 126 | 144 | -18 |
| 1975-05-22 | vs PIT | 40 | L 2-4 | 20-20 | 4 | 9,148 | Dave Freisleben | Jim Rooker | Jim Rooker | Dave Freisleben | Dave Giusti | 128 | 148 | -20 |
| 1975-05-23 | vs PIT | 41 | W 4-3 | 21-20 | 4 | 14,858 | Dan Spillner | Ken Brett | Danny Frisella | Dave Giusti | | 132 | 151 | -19 |
| 1975-05-24 | vs PIT | 42 | W 5-0 | 22-20 | 4 | 22,758 | Randy Jones | Jerry Reuss | Randy Jones | Jerry Reuss | | 137 | 151 | -14 |
| 1975-05-25 | vs PIT | 43 | L 5-6 | 22-21 | 4 | 28,778 | Alan Foster | Bob Moose | Ramon Hernandez | Danny Frisella | Larry Demery | 142 | 157 | -15 |
| 1975-05-26 | @ SLN | 44 | W 9-6 | 23-21 | 4 | 12,430 | Joe McIntosh | Bob Gibson | Bill Greif | Al Hrabosky | Danny Frisella | 151 | 163 | -12 |
| 1975-05-27 | @ SLN | 45 | L 1-7 | 23-22 | 4 | 10,060 | Dave Freisleben | Bob Forsch | Bob Forsch | Dave Freisleben | | 152 | 170 | -18 |
| 1975-05-28 | @ SLN | 46 | L 5-6 | 23-23 | 4 | 11,690 | Dan Spillner | Lynn McGlothen | Mike Garman | Bill Greif | | 157 | 176 | -19 |
| 1975-05-30 | @ NYN | 47 | W 6-2 | 24-23 | 4 | 12,208 | Randy Jones | Jerry Koosman | Randy Jones | Jerry Koosman | | 163 | 178 | -15 |
| 1975-05-31 | @ NYN | 48 | L 2-7 | 24-24 | 4 | 21,049 | Joe McIntosh | Tom Seaver | Tom Seaver | Joe McIntosh | | 165 | 185 | -20 |
| 1975-06-01 | @ NYN | 49 | W 4-0 | 25-24 | 4 | 12,072 | Alan Foster | Randy Tate | Alan Foster | Randy Tate | Danny Frisella | 169 | 185 | -16 |
| 1975-06-02 | @ PHI | 50 | L 1-5 | 25-25 | 4 | 9,348 | Dave Freisleben | Steve Carlton | Steve Carlton | Dave Freisleben | | 170 | 190 | -20 |
| 1975-06-03 | @ PHI | 51 | L 1-12 | 25-26 | 4 | 10,047 | Dan Spillner | Jim Lonborg | Jim Lonborg | Dan Spillner | | 171 | 202 | -31 |
| 1975-06-04 | @ PHI | 52 | L 2-7 | 25-27 | 4 | 12,443 | Randy Jones | Wayne Twitchell | Wayne Twitchell | Randy Jones | Tug McGraw | 173 | 209 | -36 |
| 1975-06-08 | @ MON | 53 | W 5-2 | 26-28 | 4 | 0 | Joe McIntosh | Dave McNally | Joe McIntosh | Dave McNally | | 178 | 211 | -33 |
| 1975-06-08 | @ MON | 54 | L 1-3 | 26-28 | 4 | 11,882 | Dave Freisleben | Steve Rogers | Steve Rogers | Dave Freisleben | | 179 | 214 | -35 |
| 1975-06-09 | vs PHI | 55 | W 8-3 | 27-28 | 4 | 30,948 | Randy Jones | Wayne Twitchell | Randy Jones | Wayne Twitchell | | 187 | 217 | -30 |
| 1975-06-10 | vs PHI | 56 | L 0-7 | 27-29 | 4 | 15,909 | Dan Spillner | Larry Christenson | Larry Christenson | Dan Spillner | | 187 | 224 | -37 |
| 1975-06-11 | vs MON | 57 | W 3-1 | 28-29 | 4 | 8,752 | Rich Folkers | Dennis Blair | Rich Folkers | Dennis Blair | Danny Frisella | 190 | 225 | -35 |
| 1975-06-12 | vs MON | 58 | L 2-3 | 28-30 | 4 | 9,927 | Dave Freisleben | Steve Rogers | Don DeMola | Danny Frisella | Steve Renko | 192 | 228 | -36 |
| 1975-06-13 | vs NYN | 59 | L 2-7 | 28-31 | 4 | 16,099 | Joe McIntosh | George Stone | George Stone | Joe McIntosh | | 194 | 235 | -41 |
| 1975-06-14 | vs NYN | 60 | W 7-1 | 29-31 | 4 | 16,049 | Randy Jones | Jerry Koosman | Randy Jones | Jerry Koosman | | 201 | 236 | -35 |
| 1975-06-15 | vs NYN | 61 | L 0-6 | 29-32 | 3 | 24,199 | Brent Strom | Tom Seaver | Tom Seaver | Brent Strom | | 201 | 242 | -41 |
| 1975-06-16 | @ SFN | 62 | W 7-1 | 30-32 | 3 | 1,851 | Rich Folkers | Ed Halicki | Rich Folkers | Ed Halicki | | 208 | 243 | -35 |
| 1975-06-17 | @ SFN | 63 | L 1-3 | 30-33 | 3 | 2,482 | Dave Freisleben | Pete Falcone | Pete Falcone | Dave Freisleben | | 209 | 246 | -37 |
| 1975-06-18 | @ SFN | 64 | L 1-8 | 30-34 | 4 | 3,114 | Joe McIntosh | John Montefusco | John Montefusco | Joe McIntosh | | 210 | 254 | -44 |
| 1975-06-19 | vs LAN | 65 | L 1-4 | 30-35 | 4 | 21,533 | Randy Jones | Doug Rau | Doug Rau | Randy Jones | Mike Marshall | 211 | 258 | -47 |
| 1975-06-20 | vs LAN | 66 | W 2-1 | 31-35 | 4 | 22,822 | Brent Strom | Don Sutton | Brent Strom | Don Sutton | | 213 | 259 | -46 |
| 1975-06-21 | vs LAN | 67 | L 3-4 | 31-36 | 4 | 29,988 | Rich Folkers | Andy Messersmith | Andy Messersmith | Rich Folkers | | 216 | 263 | -47 |
| 1975-06-22 | vs LAN | 68 | L 2-3 | 31-37 | 4 | 32,176 | Dave Freisleben | Al Downing | Mike Marshall | Danny Frisella | | 218 | 266 | -48 |
| 1975-06-23 | vs SFN | 69 | W 7-6 | 32-37 | 4 | 6,999 | Joe McIntosh | John Montefusco | Dave Tomlin | Gary Lavelle | Bill Greif | 225 | 272 | -47 |
| 1975-06-24 | vs SFN | 70 | W 2-1 | 34-37 | 3 | 0 | Randy Jones | Jim Barr | Randy Jones | Gary Lavelle | | 227 | 273 | -46 |
| 1975-06-24 | vs SFN | 71 | W 3-0 | 34-37 | 3 | 19,817 | Brent Strom | Tom Bradley | Brent Strom | Tom Bradley | | 230 | 273 | -43 |
| 1975-06-25 | vs SFN | 72 | W 6-2 | 35-37 | 3 | 11,734 | Rich Folkers | Mike Caldwell | Rich Folkers | Mike Caldwell | | 236 | 275 | -39 |
| 1975-06-27 | @ CIN | 73 | L 2-5 | 35-38 | 3 | 31,076 | Dave Freisleben | Clay Carroll | Will McEnaney | Danny Frisella | | 238 | 280 | -42 |
| 1975-06-28 | @ CIN | 74 | L 4-6 | 35-39 | 4 | 48,747 | Joe McIntosh | Gary Nolan | Will McEnaney | Dave Tomlin | | 242 | 286 | -44 |
| 1975-06-29 | @ CIN | 75 | L 1-4 | 36-40 | 4 | 0 | Randy Jones | Jack Billingham | Jack Billingham | Randy Jones | Will McEnaney | 243 | 290 | -47 |
| 1975-06-29 | @ CIN | 76 | W 4-3 | 36-40 | 4 | 46,060 | Brent Strom | Pat Darcy | Brent Strom | Pat Darcy | | 247 | 293 | -46 |
| 1975-06-30 | @ LAN | 77 | L 1-4 | 36-41 | 4 | 29,678 | Rich Folkers | Andy Messersmith | Andy Messersmith | Rich Folkers | | 248 | 297 | -49 |
| 1975-07-01 | @ LAN | 78 | W 10-1 | 37-41 | 4 | 21,542 | Dan Spillner | Burt Hooton | Dan Spillner | Burt Hooton | | 258 | 298 | -40 |
| 1975-07-02 | @ LAN | 79 | L 5-6 | 37-42 | 4 | 21,483 | Dave Freisleben | Doug Rau | Al Downing | Joe McIntosh | | 263 | 304 | -41 |
| 1975-07-03 | vs CIN | 80 | W 2-1 | 38-42 | 4 | 15,145 | Randy Jones | Gary Nolan | Randy Jones | Will McEnaney | | 265 | 305 | -40 |
| 1975-07-04 | vs CIN | 81 | L 6-7 | 38-43 | 4 | 47,076 | Rich Folkers | Jack Billingham | Jack Billingham | Rich Folkers | Will McEnaney | 271 | 312 | -41 |
| 1975-07-05 | vs CIN | 82 | L 3-6 | 38-44 | 5 | 49,618 | Brent Strom | Fred Norman | Fred Norman | Brent Strom | Rawly Eastwick | 274 | 318 | -44 |
| 1975-07-06 | vs CIN | 83 | L 2-13 | 38-45 | 5 | 16,932 | Joe McIntosh | Clay Kirby | Clay Kirby | Joe McIntosh | Pedro Borbon | 276 | 331 | -55 |
| 1975-07-08 | @ CHN | 84 | W 8-6 | 39-45 | 4 | 12,240 | Randy Jones | Steve Stone | Joe McIntosh | Tom Dettore | | 284 | 337 | -53 |
| 1975-07-09 | @ CHN | 85 | W 3-2 | 40-45 | 3 | 14,301 | Brent Strom | Geoff Zahn | Brent Strom | Geoff Zahn | Bill Greif | 287 | 339 | -52 |
| 1975-07-10 | @ CHN | 86 | L 1-3 | 40-46 | 4 | 10,724 | Dave Freisleben | Ray Burris | Ray Burris | Dave Freisleben | | 288 | 342 | -54 |
| 1975-07-11 | @ PIT | 87 | L 2-6 | 40-48 | 4 | 0 | Rich Folkers | Jim Rooker | Jim Rooker | Rich Folkers | Dave Giusti | 290 | 348 | -58 |
| 1975-07-11 | @ PIT | 88 | L 0-5 | 40-48 | 4 | 31,435 | Joe McIntosh | John Candelaria | John Candelaria | Joe McIntosh | | 290 | 353 | -63 |
| 1975-07-12 | @ PIT | 89 | L 4-6 | 40-49 | 5 | 21,877 | Randy Jones | Ken Brett | Ramon Hernandez | Randy Jones | Larry Demery | 294 | 359 | -65 |
| 1975-07-13 | @ PIT | 90 | W 7-5 | 41-49 | 5 | 20,113 | Brent Strom | Dock Ellis | Brent Strom | Dock Ellis | Dan Spillner | 301 | 364 | -63 |
| 1975-07-17 | vs CHN | 91 | L 5-6 | 41-50 | 5 | 10,647 | Brent Strom | Rick Reuschel | Rick Reuschel | Brent Strom | Darold Knowles | 306 | 370 | -64 |
| 1975-07-18 | vs CHN | 92 | W 4-2 | 42-50 | 5 | 14,151 | Randy Jones | Ray Burris | Bill Greif | Milt Wilcox | Danny Frisella | 310 | 372 | -62 |
| 1975-07-19 | vs CHN | 93 | W 2-1 | 43-50 | 4 | 20,251 | Dave Freisleben | Steve Stone | Dave Freisleben | Steve Stone | | 312 | 373 | -61 |
| 1975-07-20 | vs SLN | 94 | L 1-3 | 43-52 | 4 | 0 | Joe McIntosh | Ron Reed | Al Hrabosky | Bill Greif | | 313 | 376 | -63 |
| 1975-07-20 | vs SLN | 95 | L 2-10 | 43-52 | 4 | 24,031 | Rich Folkers | John Curtis | John Curtis | Rich Folkers | | 315 | 386 | -71 |
| 1975-07-21 | vs SLN | 96 | L 0-4 | 43-53 | 5 | 7,493 | Brent Strom | Eric Rasmussen | Eric Rasmussen | Brent Strom | | 315 | 390 | -75 |
| 1975-07-22 | vs PIT | 97 | W 1-0 | 44-53 | 4 | 14,437 | Randy Jones | Bruce Kison | Randy Jones | Bruce Kison | | 316 | 390 | -74 |
| 1975-07-23 | vs PIT | 98 | L 1-8 | 44-54 | 4 | 14,547 | Dave Freisleben | Dock Ellis | Dock Ellis | Dave Freisleben | | 317 | 398 | -81 |
| 1975-07-25 | @ ATL | 99 | W 7-3 | 46-54 | 4 | 0 | Joe McIntosh | Ray Sadecki | Joe McIntosh | Ray Sadecki | Bill Greif | 324 | 401 | -77 |
| 1975-07-25 | @ ATL | 100 | W 8-1 | 46-54 | 4 | 9,860 | Dan Spillner | Mike Thompson | Dan Spillner | Mike Thompson | | 332 | 402 | -70 |
| 1975-07-26 | @ ATL | 101 | W 4-2 | 47-54 | 4 | 12,225 | Jerry Johnson | Carl Morton | Jerry Johnson | Carl Morton | Danny Frisella | 336 | 404 | -68 |
| 1975-07-27 | @ ATL | 102 | W 3-1 | 48-54 | 4 | 4,496 | Randy Jones | Bruce Dal Canton | Randy Jones | Bruce Dal Canton | | 339 | 405 | -66 |
| 1975-07-28 | @ HOU | 103 | W 2-0 | 49-54 | 4 | 6,826 | Dave Freisleben | Larry Dierker | Dave Freisleben | Larry Dierker | | 341 | 405 | -64 |
| 1975-07-29 | @ HOU | 104 | L 2-6 | 49-55 | 4 | 7,156 | Dan Spillner | Dave Roberts | Dave Roberts | Dan Spillner | | 343 | 411 | -68 |
| 1975-07-30 | @ HOU | 105 | L 4-8 | 49-56 | 4 | 7,547 | Joe McIntosh | Doug Konieczny | Doug Konieczny | Joe McIntosh | Jose Sosa | 347 | 419 | -72 |
| 1975-07-31 | @ HOU | 106 | W 5-3 | 50-56 | 4 | 7,475 | Jerry Johnson | Ken Forsch | Dave Tomlin | Wayne Granger | Bill Greif | 352 | 422 | -70 |
| 1975-08-01 | vs ATL | 107 | W 4-0 | 51-56 | 4 | 11,348 | Randy Jones | Phil Niekro | Randy Jones | Phil Niekro | | 356 | 422 | -66 |
| 1975-08-02 | vs ATL | 108 | L 6-8 | 51-57 | 4 | 26,892 | Dave Freisleben | Blue Moon Odom | Mike Beard | Joe McIntosh | | 362 | 430 | -68 |
| 1975-08-03 | vs ATL | 109 | L 1-5 | 51-58 | 4 | 8,850 | Dan Spillner | Carl Morton | Carl Morton | Dan Spillner | | 363 | 435 | -72 |
| 1975-08-04 | vs HOU | 110 | L 3-5 | 51-59 | 4 | 15,000 | Dave Freisleben | Joe Niekro | Joe Niekro | Dave Freisleben | Mike Cosgrove | 366 | 440 | -74 |
| 1975-08-05 | vs HOU | 111 | W 6-5 | 52-59 | 4 | 6,874 | Jerry Johnson | J.R. Richard | Bill Greif | Wayne Granger | | 372 | 445 | -73 |
| 1975-08-06 | vs HOU | 112 | W 6-1 | 53-59 | 4 | 16,661 | Randy Jones | Larry Dierker | Randy Jones | Larry Dierker | | 378 | 446 | -68 |
| 1975-08-08 | @ SLN | 113 | L 6-10 | 53-60 | 4 | 23,534 | Dan Spillner | Bob Forsch | Bob Forsch | Dan Spillner | | 384 | 456 | -72 |
| 1975-08-09 | @ SLN | 114 | L 1-6 | 53-61 | 4 | 25,031 | Dave Freisleben | Lynn McGlothen | Lynn McGlothen | Dave Freisleben | | 385 | 462 | -77 |
| 1975-08-10 | @ SLN | 115 | L 2-3 | 53-62 | 4 | 26,474 | Joe McIntosh | Ron Reed | Al Hrabosky | Bill Greif | | 387 | 465 | -78 |
| 1975-08-11 | @ NYN | 116 | L 4-8 | 53-63 | 4 | 14,382 | Randy Jones | George Stone | Skip Lockwood | Randy Jones | | 391 | 473 | -82 |
| 1975-08-12 | @ NYN | 117 | L 4-9 | 53-64 | 4 | 20,259 | Jerry Johnson | Tom Seaver | Tom Seaver | Jerry Johnson | | 395 | 482 | -87 |
| 1975-08-13 | @ NYN | 118 | W 8-5 | 54-64 | 4 | 16,027 | Dan Spillner | Randy Tate | Rich Folkers | Randy Tate | | 403 | 487 | -84 |
| 1975-08-15 | @ PHI | 119 | L 3-4 | 54-65 | 4 | 30,601 | Joe McIntosh | Dick Ruthven | Tom Hilgendorf | Joe McIntosh | Tug McGraw | 406 | 491 | -85 |
| 1975-08-16 | @ PHI | 120 | W 5-1 | 55-65 | 4 | 40,127 | Randy Jones | Larry Christenson | Randy Jones | Tug McGraw | | 411 | 492 | -81 |
| 1975-08-17 | @ PHI | 121 | L 4-10 | 55-66 | 4 | 29,317 | Dave Freisleben | Tom Underwood | Tom Underwood | Dave Freisleben | Gene Garber | 415 | 502 | -87 |
| 1975-08-18 | @ MON | 122 | L 1-4 | 56-67 | 4 | 0 | Dan Spillner | Dan Warthen | Dan Warthen | Dave Tomlin | Dale Murray | 416 | 506 | -90 |
| 1975-08-18 | @ MON | 123 | W 5-2 | 56-67 | 4 | 15,232 | Rich Folkers | Woodie Fryman | Rich Folkers | Woodie Fryman | | 421 | 508 | -87 |
| 1975-08-19 | @ MON | 124 | L 0-5 | 56-68 | 4 | 12,114 | Joe McIntosh | Steve Rogers | Steve Rogers | Joe McIntosh | | 421 | 513 | -92 |
| 1975-08-20 | @ MON | 125 | W 8-6 | 57-68 | 4 | 12,470 | Randy Jones | Don Carrithers | Jerry Johnson | Woodie Fryman | Danny Frisella | 429 | 519 | -90 |
| 1975-08-22 | vs PHI | 126 | L 5-6 | 57-69 | 4 | 13,426 | Dave Freisleben | Tom Underwood | Tom Hilgendorf | Bill Greif | Gene Garber | 434 | 525 | -91 |
| 1975-08-23 | vs PHI | 127 | W 8-3 | 58-69 | 4 | 9,578 | Dan Spillner | Steve Carlton | Dan Spillner | Steve Carlton | Danny Frisella | 442 | 528 | -86 |
| 1975-08-24 | vs PHI | 128 | W 7-2 | 60-69 | 4 | 0 | Randy Jones | Dick Ruthven | Randy Jones | Dick Ruthven | | 449 | 530 | -81 |
| 1975-08-24 | vs PHI | 129 | W 7-6 | 60-69 | 4 | 17,870 | Joe McIntosh | Jim Lonborg | Bill Greif | Ron Schueler | | 456 | 536 | -80 |
| 1975-08-25 | vs NYN | 130 | L 0-4 | 60-70 | 4 | 6,358 | Brent Strom | Hank Webb | Hank Webb | Brent Strom | | 456 | 540 | -84 |
| 1975-08-26 | vs NYN | 131 | L 2-7 | 60-71 | 4 | 14,779 | Dave Freisleben | Randy Tate | Randy Tate | Dave Freisleben | | 458 | 547 | -89 |
| 1975-08-27 | vs NYN | 132 | L 0-7 | 60-72 | 4 | 8,524 | Dan Spillner | Tom Seaver | Tom Seaver | Dan Spillner | | 458 | 554 | -96 |
| 1975-08-28 | vs MON | 133 | L 8-10 | 60-73 | 4 | 6,059 | Randy Jones | Steve Rogers | Fred Scherman | Randy Jones | Dale Murray | 466 | 564 | -98 |
| 1975-08-29 | vs MON | 134 | L 0-4 | 60-74 | 4 | 4,976 | Joe McIntosh | Don Carrithers | Don Carrithers | Joe McIntosh | | 466 | 568 | -102 |
| 1975-08-30 | vs MON | 135 | L 1-5 | 60-75 | 4 | 5,268 | Rich Folkers | Steve Renko | Steve Renko | Rich Folkers | | 467 | 573 | -106 |
| 1975-08-31 | vs MON | 136 | W 6-0 | 61-75 | 4 | 9,876 | Brent Strom | Dan Warthen | Brent Strom | Dan Warthen | | 473 | 573 | -100 |
| 1975-09-01 | @ CIN | 137 | W 2-1 | 62-75 | 4 | 17,022 | Randy Jones | Pat Darcy | Randy Jones | Pedro Borbon | | 475 | 574 | -99 |
| 1975-09-02 | @ CIN | 138 | L 4-10 | 62-76 | 4 | 14,240 | Dan Spillner | Don Gullett | Don Gullett | Dan Spillner | | 479 | 584 | -105 |
| 1975-09-03 | @ ATL | 139 | W 10-9 | 63-76 | 4 | 1,119 | Joe McIntosh | Adrian Devine | Jerry Johnson | Tom House | Bill Greif | 489 | 593 | -104 |
| 1975-09-04 | @ ATL | 140 | L 1-2 | 63-77 | 4 | 1,062 | Rich Folkers | Phil Niekro | Bruce Dal Canton | Danny Frisella | | 490 | 595 | -105 |
| 1975-09-05 | @ HOU | 141 | L 1-2 | 63-78 | 4 | 7,088 | Randy Jones | Mike Cosgrove | J.R. Richard | Randy Jones | | 491 | 597 | -106 |
| 1975-09-06 | @ HOU | 142 | W 2-1 | 64-78 | 4 | 5,838 | Brent Strom | Doug Konieczny | Brent Strom | Doug Konieczny | | 493 | 598 | -105 |
| 1975-09-07 | @ HOU | 143 | L 2-3 | 64-79 | 4 | 5,830 | Dan Spillner | Dave Roberts | Jim York | Danny Frisella | | 495 | 601 | -106 |
| 1975-09-08 | vs CIN | 144 | L 2-3 | 64-80 | 4 | 27,267 | Joe McIntosh | Gary Nolan | Clay Carroll | Bill Greif | Rawly Eastwick | 497 | 604 | -107 |
| 1975-09-09 | vs CIN | 145 | W 11-2 | 65-80 | 4 | 12,444 | Rich Folkers | Clay Kirby | Rich Folkers | Clay Kirby | | 508 | 606 | -98 |
| 1975-09-10 | vs ATL | 146 | W 2-1 | 66-80 | 4 | 6,648 | Randy Jones | Carl Morton | Randy Jones | Bruce Dal Canton | | 510 | 607 | -97 |
| 1975-09-11 | vs ATL | 147 | W 4-3 | 67-80 | 4 | 3,712 | Brent Strom | Mike Beard | Brent Strom | Tom House | | 514 | 610 | -96 |
| 1975-09-12 | vs HOU | 148 | W 1-0 | 68-80 | 4 | 8,184 | Dan Spillner | Paul Siebert | Dave Tomlin | Jim York | | 515 | 610 | -95 |
| 1975-09-14 | vs HOU | 149 | L 2-4 | 68-81 | 4 | 19,442 | Randy Jones | J.R. Richard | J.R. Richard | Randy Jones | Joe Niekro | 517 | 614 | -97 |
| 1975-09-15 | @ LAN | 150 | L 4-5 | 68-82 | 4 | 12,233 | Rich Folkers | Burt Hooton | Burt Hooton | Joe McIntosh | | 521 | 619 | -98 |
| 1975-09-16 | @ LAN | 151 | L 2-5 | 68-83 | 4 | 12,032 | Brent Strom | Rick Rhoden | Rick Rhoden | Brent Strom | Charlie Hough | 523 | 624 | -101 |
| 1975-09-17 | @ LAN | 152 | L 1-7 | 68-84 | 4 | 13,465 | Dan Spillner | Andy Messersmith | Andy Messersmith | Dan Spillner | | 524 | 631 | -107 |
| 1975-09-19 | @ SFN | 153 | L 1-3 | 68-85 | 4 | 1,718 | Randy Jones | Mike Caldwell | Mike Caldwell | Randy Jones | | 525 | 634 | -109 |
| 1975-09-20 | @ SFN | 154 | L 2-4 | 68-86 | 4 | 2,305 | Rich Folkers | Pete Falcone | Pete Falcone | Rich Folkers | Randy Moffitt | 527 | 638 | -111 |
| 1975-09-21 | @ SFN | 155 | L 1-2 | 68-87 | 4 | 15,447 | Brent Strom | John Montefusco | John Montefusco | Brent Strom | | 528 | 640 | -112 |
| 1975-09-22 | vs LAN | 156 | W 6-5 | 69-87 | 4 | 5,880 | Dave Freisleben | Andy Messersmith | Butch Metzger | Dave Sells | | 534 | 645 | -111 |
| 1975-09-23 | vs LAN | 157 | W 6-4 | 70-87 | 4 | 13,565 | Randy Jones | Al Downing | Randy Jones | Stan Wall | | 540 | 649 | -109 |
| 1975-09-24 | vs LAN | 158 | L 0-14 | 70-88 | 4 | 9,262 | Rich Folkers | Doug Rau | Doug Rau | Rich Folkers | | 540 | 663 | -123 |
| 1975-09-25 | vs SFN | 159 | W 8-6 | 71-88 | 4 | 3,886 | Bill Greif | Mike Caldwell | Dave Tomlin | Mike Caldwell | Danny Frisella | 548 | 669 | -121 |
| 1975-09-26 | vs SFN | 160 | L 0-5 | 71-89 | 4 | 7,488 | Brent Strom | John Montefusco | John Montefusco | Brent Strom | | 548 | 674 | -126 |
| 1975-09-27 | vs SFN | 161 | L 1-4 | 71-90 | 4 | 27,655 | Joe McIntosh | Rob Dressler | Rob Dressler | Joe McIntosh | | 549 | 678 | -129 |
| 1975-09-28 | vs SFN | 162 | L 3-5 | 71-91 | 4 | 15,069 | Randy Jones | Greg Minton | Greg Minton | Randy Jones | Gary Lavelle | 552 | 683 | -131 |