| 1975-04-10 | @ CHN | 1 | W 8-4 | 1-0 | 1 | 19,239 | Dock Ellis | Bill Bonham | Dave Giusti | Ken Frailing | | 8 | 4 | 4 |
| 1975-04-11 | vs NYN | 2 | W 4-3 | 2-0 | 1 | 43,880 | Jerry Reuss | Jerry Koosman | Larry Demery | Rick Baldwin | | 12 | 7 | 5 |
| 1975-04-13 | vs NYN | 3 | W 5-3 | 3-0 | 1 | 14,841 | Bruce Kison | Tom Seaver | Bruce Kison | Tom Seaver | | 17 | 10 | 7 |
| 1975-04-14 | vs CHN | 4 | L 2-4 | 3-1 | 2 | 4,780 | Bob Moose | Rick Reuschel | Rick Reuschel | Bob Moose | Darold Knowles | 19 | 14 | 5 |
| 1975-04-16 | vs MON | 5 | L 0-5 | 3-2 | 3 | 4,807 | Dock Ellis | Woodie Fryman | Woodie Fryman | Dock Ellis | | 19 | 19 | 0 |
| 1975-04-17 | vs MON | 6 | L 4-7 | 3-3 | 3 | 5,667 | Jerry Reuss | Dave McNally | Dave McNally | Jerry Reuss | | 23 | 26 | -3 |
| 1975-04-18 | @ SLN | 7 | L 4-5 | 3-4 | 4 | 19,975 | Bruce Kison | Bob Gibson | Ray Sadecki | Sam McDowell | | 27 | 31 | -4 |
| 1975-04-19 | @ SLN | 8 | W 7-1 | 4-4 | 4 | 19,775 | Jim Rooker | Bob Forsch | Jim Rooker | Bob Forsch | | 34 | 32 | 2 |
| 1975-04-20 | @ SLN | 9 | W 5-0 | 5-4 | 2 | 20,935 | Ken Brett | John Denny | Ken Brett | John Denny | Dave Giusti | 39 | 32 | 7 |
| 1975-04-22 | @ MON | 10 | L 3-4 | 5-5 | 3 | 5,239 | Dock Ellis | Dave McNally | Dave McNally | Dock Ellis | Dale Murray | 42 | 36 | 6 |
| 1975-04-23 | @ MON | 11 | L 0-5 | 5-6 | 5 | 8,177 | Jerry Reuss | Woodie Fryman | Woodie Fryman | Jerry Reuss | | 42 | 41 | 1 |
| 1975-04-25 | vs PHI | 12 | W 3-2 | 6-6 | 3 | 5,726 | Bruce Kison | Steve Carlton | Bruce Kison | Steve Carlton | Dave Giusti | 45 | 43 | 2 |
| 1975-04-26 | vs PHI | 13 | W 7-3 | 7-6 | 3 | 13,120 | Jim Rooker | Wayne Twitchell | Jim Rooker | Wayne Twitchell | | 52 | 46 | 6 |
| 1975-04-27 | vs PHI | 14 | W 2-0 | 8-6 | 3 | 14,074 | Dock Ellis | Tom Underwood | Dock Ellis | Tom Underwood | | 54 | 46 | 8 |
| 1975-04-29 | vs SLN | 15 | L 0-3 | 8-7 | 3 | 6,319 | Ken Brett | Lynn McGlothen | Lynn McGlothen | Ken Brett | | 54 | 49 | 5 |
| 1975-04-30 | vs SLN | 16 | W 5-0 | 9-7 | 3 | 5,584 | Jerry Reuss | Bob Gibson | Jerry Reuss | Bob Gibson | | 59 | 49 | 10 |
| 1975-05-02 | @ PHI | 17 | L 5-9 | 9-8 | 3 | 20,257 | Bruce Kison | Wayne Twitchell | Wayne Twitchell | Bruce Kison | Tug McGraw | 64 | 58 | 6 |
| 1975-05-03 | @ PHI | 18 | L 2-6 | 9-10 | 4 | 0 | Jim Rooker | Tom Underwood | Tom Underwood | Jim Rooker | Gene Garber | 66 | 64 | 2 |
| 1975-05-03 | @ PHI | 19 | L 3-4 | 9-10 | 4 | 44,501 | Dock Ellis | Jim Lonborg | Tug McGraw | Ramon Hernandez | | 69 | 68 | 1 |
| 1975-05-06 | @ NYN | 20 | W 2-1 | 10-10 | 4 | 8,257 | Ken Brett | Tom Seaver | Ken Brett | Tom Seaver | | 71 | 69 | 2 |
| 1975-05-07 | @ NYN | 21 | W 6-1 | 11-10 | 2 | 12,216 | Jerry Reuss | Jon Matlack | Jerry Reuss | Jon Matlack | | 77 | 70 | 7 |
| 1975-05-08 | @ NYN | 22 | W 4-2 | 12-10 | 2 | 14,053 | Bruce Kison | Jerry Koosman | Bruce Kison | Jerry Koosman | | 81 | 72 | 9 |
| 1975-05-09 | vs LAN | 23 | W 11-3 | 13-10 | 2 | 16,378 | Dock Ellis | Burt Hooton | Dock Ellis | Mike Marshall | Dave Giusti | 92 | 75 | 17 |
| 1975-05-10 | vs LAN | 24 | L 2-6 | 13-11 | 2 | 24,870 | Jim Rooker | Doug Rau | Doug Rau | Jim Rooker | | 94 | 81 | 13 |
| 1975-05-11 | vs LAN | 25 | L 0-7 | 13-12 | 2 | 15,175 | Ken Brett | Don Sutton | Don Sutton | Ken Brett | | 94 | 88 | 6 |
| 1975-05-13 | vs SDN | 26 | W 2-0 | 14-12 | 2 | 5,482 | Jerry Reuss | Dan Spillner | Jerry Reuss | Dan Spillner | | 96 | 88 | 8 |
| 1975-05-14 | vs SDN | 27 | W 5-4 | 15-12 | 2 | 8,334 | Dock Ellis | Randy Jones | Sam McDowell | Bill Greif | | 101 | 92 | 9 |
| 1975-05-16 | @ LAN | 28 | W 3-2 | 16-12 | 2 | 44,111 | Bruce Kison | Don Sutton | Dave Giusti | Don Sutton | | 104 | 94 | 10 |
| 1975-05-17 | @ LAN | 29 | L 3-4 | 16-13 | 3 | 46,790 | Jim Rooker | Andy Messersmith | Andy Messersmith | Ramon Hernandez | | 107 | 98 | 9 |
| 1975-05-18 | @ LAN | 30 | W 7-2 | 17-13 | 3 | 42,013 | Ken Brett | Burt Hooton | Ken Brett | Burt Hooton | | 114 | 100 | 14 |
| 1975-05-19 | @ SFN | 31 | L 4-6 | 17-14 | 3 | 1,795 | Jerry Reuss | Mike Caldwell | Mike Caldwell | Jerry Reuss | | 118 | 106 | 12 |
| 1975-05-20 | @ SFN | 32 | L 4-12 | 17-15 | 3 | 1,759 | Dock Ellis | Ed Halicki | Ed Halicki | Dock Ellis | | 122 | 118 | 4 |
| 1975-05-21 | @ SFN | 33 | L 1-2 | 17-16 | 3 | 3,513 | Bruce Kison | John Montefusco | Jim Barr | Dave Giusti | | 123 | 120 | 3 |
| 1975-05-22 | @ SDN | 34 | W 4-2 | 18-16 | 3 | 9,148 | Jim Rooker | Dave Freisleben | Jim Rooker | Dave Freisleben | Dave Giusti | 127 | 122 | 5 |
| 1975-05-23 | @ SDN | 35 | L 3-4 | 18-17 | 4 | 14,858 | Ken Brett | Dan Spillner | Danny Frisella | Dave Giusti | | 130 | 126 | 4 |
| 1975-05-24 | @ SDN | 36 | L 0-5 | 18-18 | 4 | 22,758 | Jerry Reuss | Randy Jones | Randy Jones | Jerry Reuss | | 130 | 131 | -1 |
| 1975-05-25 | @ SDN | 37 | W 6-5 | 19-18 | 3 | 28,778 | Bob Moose | Alan Foster | Ramon Hernandez | Danny Frisella | Larry Demery | 136 | 136 | 0 |
| 1975-05-26 | vs HOU | 38 | W 10-2 | 20-18 | 3 | 11,126 | Bruce Kison | J.R. Richard | Bruce Kison | J.R. Richard | | 146 | 138 | 8 |
| 1975-05-27 | vs HOU | 39 | W 6-5 | 21-18 | 2 | 7,003 | Jim Rooker | Larry Dierker | Larry Demery | Joe Niekro | | 152 | 143 | 9 |
| 1975-05-28 | vs HOU | 40 | W 3-0 | 22-18 | 2 | 7,601 | Ken Brett | Dave Roberts | Ken Brett | Dave Roberts | | 155 | 143 | 12 |
| 1975-05-30 | vs ATL | 41 | W 2-1 | 23-18 | 1 | 11,565 | Jerry Reuss | Buzz Capra | Jerry Reuss | Buzz Capra | | 157 | 144 | 13 |
| 1975-05-31 | vs ATL | 42 | W 11-4 | 24-18 | 1 | 13,423 | Bruce Kison | Roric Harrison | Bruce Kison | Roric Harrison | | 168 | 148 | 20 |
| 1975-06-01 | vs ATL | 43 | L 2-5 | 24-19 | 2 | 37,373 | Jim Rooker | Phil Niekro | Phil Niekro | Jim Rooker | | 170 | 153 | 17 |
| 1975-06-03 | vs CIN | 44 | L 4-8 | 24-20 | 2 | 9,438 | Bob Moose | Gary Nolan | Gary Nolan | Bob Moose | | 174 | 161 | 13 |
| 1975-06-04 | vs CIN | 45 | W 2-1 | 25-20 | 2 | 13,754 | Jerry Reuss | Fred Norman | Jerry Reuss | Fred Norman | Ramon Hernandez | 176 | 162 | 14 |
| 1975-06-06 | vs SFN | 46 | W 7-2 | 26-20 | 1 | 11,923 | Bruce Kison | Jim Barr | Bruce Kison | Jim Barr | | 183 | 164 | 19 |
| 1975-06-07 | vs SFN | 47 | W 7-6 | 27-20 | 1 | 8,668 | Jim Rooker | Mike Caldwell | Ramon Hernandez | Tommy Toms | Dave Giusti | 190 | 170 | 20 |
| 1975-06-08 | vs SFN | 48 | L 1-3 | 27-22 | 1 | 0 | John Candelaria | Ed Halicki | Ed Halicki | John Candelaria | | 191 | 173 | 18 |
| 1975-06-08 | vs SFN | 49 | L 2-4 | 27-22 | 1 | 24,128 | Larry Demery | Charlie Williams | Gary Lavelle | Larry Demery | Randy Moffitt | 193 | 177 | 16 |
| 1975-06-09 | @ CIN | 50 | W 9-2 | 28-22 | 1 | 22,555 | Jerry Reuss | Fred Norman | Jerry Reuss | Fred Norman | | 202 | 179 | 23 |
| 1975-06-10 | @ CIN | 51 | W 9-5 | 29-22 | 1 | 19,107 | Sam McDowell | Pat Darcy | Sam McDowell | Pat Darcy | Ramon Hernandez | 211 | 184 | 27 |
| 1975-06-11 | @ HOU | 52 | L 1-5 | 29-23 | 1 | 10,125 | Bruce Kison | Larry Dierker | Larry Dierker | Bruce Kison | | 212 | 189 | 23 |
| 1975-06-12 | @ HOU | 53 | W 4-2 | 30-23 | 1 | 10,802 | Dock Ellis | Dave Roberts | Dock Ellis | Dave Roberts | Larry Demery | 216 | 191 | 25 |
| 1975-06-13 | @ ATL | 54 | W 8-3 | 31-23 | 1 | 8,998 | Jim Rooker | Blue Moon Odom | Jim Rooker | Blue Moon Odom | | 224 | 194 | 30 |
| 1975-06-14 | @ ATL | 55 | W 2-1 | 32-23 | 1 | 29,308 | Jerry Reuss | Mike Thompson | Jerry Reuss | Mike Thompson | Dave Giusti | 226 | 195 | 31 |
| 1975-06-15 | @ ATL | 56 | W 8-6 | 33-23 | 1 | 8,352 | John Candelaria | Ray Sadecki | Larry Demery | Elias Sosa | | 234 | 201 | 33 |
| 1975-06-16 | vs SLN | 57 | W 10-4 | 34-23 | 1 | 13,003 | Bruce Kison | Ron Bryant | Bruce Kison | Ron Bryant | | 244 | 205 | 39 |
| 1975-06-17 | vs SLN | 58 | L 4-7 | 34-24 | 1 | 15,898 | Dock Ellis | Lynn McGlothen | Lynn McGlothen | Dock Ellis | Mike Garman | 248 | 212 | 36 |
| 1975-06-18 | vs SLN | 59 | W 9-3 | 35-24 | 1 | 22,345 | Jim Rooker | Ron Reed | Jim Rooker | Ron Reed | | 257 | 215 | 42 |
| 1975-06-19 | vs SLN | 60 | W 5-0 | 36-24 | 1 | 8,198 | Jerry Reuss | John Curtis | Jerry Reuss | John Curtis | | 262 | 215 | 47 |
| 1975-06-20 | @ NYN | 61 | W 5-1 | 37-24 | 1 | 47,867 | John Candelaria | Tom Seaver | John Candelaria | Tom Hall | | 267 | 216 | 51 |
| 1975-06-21 | @ NYN | 62 | W 7-3 | 38-24 | 1 | 31,610 | Bruce Kison | Jon Matlack | Ramon Hernandez | Harry Parker | | 274 | 219 | 55 |
| 1975-06-22 | @ NYN | 63 | W 2-0 | 39-24 | 1 | 34,287 | Dock Ellis | Randy Tate | Dock Ellis | Randy Tate | | 276 | 219 | 57 |
| 1975-06-23 | @ PHI | 64 | L 5-6 | 39-25 | 1 | 34,759 | Jim Rooker | Steve Carlton | Tom Hilgendorf | Larry Demery | Gene Garber | 281 | 225 | 56 |
| 1975-06-24 | @ PHI | 65 | L 3-6 | 39-27 | 1 | 0 | Jerry Reuss | Larry Christenson | Larry Christenson | Jerry Reuss | Tug McGraw | 284 | 231 | 53 |
| 1975-06-24 | @ PHI | 66 | L 1-8 | 39-27 | 1 | 50,463 | Bruce Kison | Tom Underwood | Tom Underwood | Bruce Kison | | 285 | 239 | 46 |
| 1975-06-25 | @ PHI | 67 | L 6-7 | 39-28 | 1 | 34,171 | Bob Moose | Jim Lonborg | Ron Schueler | Dave Giusti | | 291 | 246 | 45 |
| 1975-06-26 | vs CHN | 68 | W 5-2 | 40-28 | 1 | 10,394 | John Candelaria | Steve Stone | John Candelaria | Ken Frailing | | 296 | 248 | 48 |
| 1975-06-27 | vs CHN | 69 | W 5-1 | 42-28 | 1 | 0 | Dock Ellis | Geoff Zahn | Dock Ellis | Geoff Zahn | | 301 | 249 | 52 |
| 1975-06-27 | vs CHN | 70 | W 5-3 | 42-28 | 1 | 34,972 | Ken Brett | Ray Burris | Ramon Hernandez | Darold Knowles | Dave Giusti | 306 | 252 | 54 |
| 1975-06-28 | vs CHN | 71 | L 0-1 | 42-29 | 1 | 16,477 | Jim Rooker | Bill Bonham | Bill Bonham | Jim Rooker | | 306 | 253 | 53 |
| 1975-06-29 | vs CHN | 72 | W 4-3 | 44-29 | 1 | 0 | Bruce Kison | Rick Reuschel | Dave Giusti | Rick Reuschel | | 310 | 256 | 54 |
| 1975-06-29 | vs CHN | 73 | W 7-0 | 44-29 | 1 | 37,145 | Jerry Reuss | Tom Dettore | Jerry Reuss | Tom Dettore | | 317 | 256 | 61 |
| 1975-06-30 | @ MON | 74 | W 5-3 | 45-29 | 1 | 13,134 | Larry Demery | Dennis Blair | Larry Demery | Dennis Blair | Kent Tekulve | 322 | 259 | 63 |
| 1975-07-01 | @ MON | 75 | W 10-4 | 46-29 | 1 | 15,132 | John Candelaria | Woodie Fryman | John Candelaria | Woodie Fryman | | 332 | 263 | 69 |
| 1975-07-03 | @ MON | 76 | W 5-1 | 47-29 | 1 | 10,116 | Dock Ellis | Steve Rogers | Dock Ellis | Steve Rogers | | 337 | 264 | 73 |
| 1975-07-04 | @ CHN | 77 | L 1-6 | 47-31 | 1 | 0 | Bruce Kison | Steve Stone | Steve Stone | Bruce Kison | | 338 | 270 | 68 |
| 1975-07-04 | @ CHN | 78 | L 1-2 | 47-31 | 1 | 30,355 | Jerry Reuss | Geoff Zahn | Darold Knowles | Jerry Reuss | | 339 | 272 | 67 |
| 1975-07-05 | @ CHN | 79 | W 5-4 | 48-31 | 1 | 22,393 | Jim Rooker | Ray Burris | Jim Rooker | Ray Burris | Ramon Hernandez | 344 | 276 | 68 |
| 1975-07-06 | @ CHN | 80 | W 18-12 | 49-31 | 1 | 28,023 | Larry Demery | Bill Bonham | Ramon Hernandez | Ken Frailing | | 362 | 288 | 74 |
| 1975-07-07 | @ CHN | 81 | W 5-0 | 50-31 | 1 | 16,540 | Ken Brett | Rick Reuschel | Ken Brett | Rick Reuschel | Dave Giusti | 367 | 288 | 79 |
| 1975-07-08 | vs LAN | 82 | L 0-3 | 50-32 | 1 | 29,376 | Dock Ellis | Don Sutton | Don Sutton | Dock Ellis | Mike Marshall | 367 | 291 | 76 |
| 1975-07-09 | vs LAN | 83 | W 3-2 | 51-32 | 1 | 22,163 | Bruce Kison | Andy Messersmith | Bruce Kison | Andy Messersmith | Dave Giusti | 370 | 293 | 77 |
| 1975-07-10 | vs LAN | 84 | W 4-1 | 52-32 | 1 | 18,521 | Jerry Reuss | Burt Hooton | Jerry Reuss | Burt Hooton | Dave Giusti | 374 | 294 | 80 |
| 1975-07-11 | vs SDN | 85 | W 6-2 | 54-32 | 1 | 0 | Jim Rooker | Rich Folkers | Jim Rooker | Rich Folkers | Dave Giusti | 380 | 296 | 84 |
| 1975-07-11 | vs SDN | 86 | W 5-0 | 54-32 | 1 | 31,435 | John Candelaria | Joe McIntosh | John Candelaria | Joe McIntosh | | 385 | 296 | 89 |
| 1975-07-12 | vs SDN | 87 | W 6-4 | 55-32 | 1 | 21,877 | Ken Brett | Randy Jones | Ramon Hernandez | Randy Jones | Larry Demery | 391 | 300 | 91 |
| 1975-07-13 | vs SDN | 88 | L 5-7 | 55-33 | 1 | 20,113 | Dock Ellis | Brent Strom | Brent Strom | Dock Ellis | Dan Spillner | 396 | 307 | 89 |
| 1975-07-17 | @ LAN | 89 | W 5-2 | 56-33 | 1 | 32,806 | Bruce Kison | Andy Messersmith | Bruce Kison | Andy Messersmith | Dave Giusti | 401 | 309 | 92 |
| 1975-07-18 | @ LAN | 90 | L 3-4 | 56-34 | 1 | 52,506 | Dock Ellis | Doug Rau | Mike Marshall | Larry Demery | | 404 | 313 | 91 |
| 1975-07-19 | @ LAN | 91 | W 5-3 | 57-34 | 1 | 51,591 | Jerry Reuss | Don Sutton | Dave Giusti | Mike Marshall | | 409 | 316 | 93 |
| 1975-07-20 | @ SFN | 92 | L 1-2 | 58-35 | 1 | 0 | Jim Rooker | Ed Halicki | Ed Halicki | Jim Rooker | | 410 | 318 | 92 |
| 1975-07-20 | @ SFN | 93 | W 7-1 | 58-35 | 1 | 14,723 | Ken Brett | Mike Caldwell | Ken Brett | Mike Caldwell | | 417 | 319 | 98 |
| 1975-07-21 | @ SFN | 94 | L 2-7 | 58-36 | 1 | 3,417 | John Candelaria | Jim Barr | Jim Barr | John Candelaria | | 419 | 326 | 93 |
| 1975-07-22 | @ SDN | 95 | L 0-1 | 58-37 | 1 | 14,437 | Bruce Kison | Randy Jones | Randy Jones | Bruce Kison | | 419 | 327 | 92 |
| 1975-07-23 | @ SDN | 96 | W 8-1 | 59-37 | 1 | 14,547 | Dock Ellis | Dave Freisleben | Dock Ellis | Dave Freisleben | | 427 | 328 | 99 |
| 1975-07-25 | vs MON | 97 | W 6-1 | 60-37 | 1 | 20,124 | Jerry Reuss | Woodie Fryman | Jerry Reuss | Don DeMola | | 433 | 329 | 104 |
| 1975-07-26 | vs MON | 98 | L 2-5 | 60-38 | 1 | 4,394 | Jim Rooker | Steve Rogers | Steve Rogers | Jim Rooker | | 435 | 334 | 101 |
| 1975-07-27 | vs MON | 99 | W 4-1 | 62-38 | 1 | 0 | Ken Brett | Fred Scherman | Ken Brett | Fred Scherman | Larry Demery | 439 | 335 | 104 |
| 1975-07-27 | vs MON | 100 | W 5-3 | 62-38 | 1 | 27,961 | John Candelaria | Dan Warthen | Dave Giusti | Dan Warthen | | 444 | 338 | 106 |
| 1975-07-28 | vs PHI | 101 | L 2-5 | 62-39 | 1 | 30,221 | Bruce Kison | Larry Christenson | Larry Christenson | Bruce Kison | | 446 | 343 | 103 |
| 1975-07-29 | vs PHI | 102 | L 1-5 | 62-40 | 1 | 33,340 | Dock Ellis | Tom Underwood | Tom Underwood | Dock Ellis | | 447 | 348 | 99 |
| 1975-07-30 | vs PHI | 103 | W 8-1 | 63-40 | 1 | 43,260 | Jerry Reuss | Steve Carlton | Jerry Reuss | Steve Carlton | | 455 | 349 | 106 |
| 1975-07-31 | vs NYN | 104 | L 2-6 | 63-41 | 1 | 13,235 | Jim Rooker | Jerry Koosman | Jerry Koosman | Jim Rooker | | 457 | 355 | 102 |
| 1975-08-01 | vs NYN | 105 | L 2-4 | 63-42 | 1 | 18,082 | Ken Brett | George Stone | George Stone | Ken Brett | Bob Apodaca | 459 | 359 | 100 |
| 1975-08-02 | vs NYN | 106 | L 0-6 | 63-43 | 1 | 14,306 | Bruce Kison | Jon Matlack | Jon Matlack | Bruce Kison | | 459 | 365 | 94 |
| 1975-08-03 | vs NYN | 107 | W 5-4 | 65-43 | 1 | 0 | Dock Ellis | Tom Seaver | Larry Demery | Bob Apodaca | | 464 | 369 | 95 |
| 1975-08-03 | vs NYN | 108 | W 4-3 | 65-43 | 1 | 30,070 | John Candelaria | Hank Webb | John Candelaria | Hank Webb | | 468 | 372 | 96 |
| 1975-08-04 | @ SLN | 109 | L 4-5 | 65-44 | 1 | 28,097 | Jerry Reuss | John Curtis | John Curtis | Jerry Reuss | Al Hrabosky | 472 | 377 | 95 |
| 1975-08-05 | @ SLN | 110 | W 6-1 | 66-44 | 1 | 25,489 | Jim Rooker | Eric Rasmussen | Jim Rooker | Eric Rasmussen | | 478 | 378 | 100 |
| 1975-08-06 | @ SLN | 111 | L 2-4 | 66-45 | 1 | 23,985 | Ken Brett | John Denny | John Denny | Ken Brett | Al Hrabosky | 480 | 382 | 98 |
| 1975-08-07 | @ HOU | 112 | L 1-6 | 66-46 | 1 | 15,255 | Bruce Kison | Dave Roberts | Dave Roberts | Bruce Kison | | 481 | 388 | 93 |
| 1975-08-08 | @ HOU | 113 | L 3-5 | 66-47 | 1 | 14,889 | Dock Ellis | Doug Konieczny | Jim Crawford | Kent Tekulve | | 484 | 393 | 91 |
| 1975-08-09 | @ HOU | 114 | L 0-5 | 66-48 | 1 | 13,531 | Jerry Reuss | Joe Niekro | Joe Niekro | Jerry Reuss | | 484 | 398 | 86 |
| 1975-08-10 | @ HOU | 115 | L 3-5 | 66-49 | 1 | 12,243 | Jim Rooker | J.R. Richard | J.R. Richard | Jim Rooker | Mike Cosgrove | 487 | 403 | 84 |
| 1975-08-11 | @ ATL | 116 | W 8-1 | 67-49 | 1 | 4,701 | John Candelaria | Jamie Easterly | John Candelaria | Jamie Easterly | Kent Tekulve | 495 | 404 | 91 |
| 1975-08-12 | @ ATL | 117 | L 2-3 | 67-50 | 1 | 4,506 | Bruce Kison | Carl Morton | Carl Morton | Bruce Kison | Tom House | 497 | 407 | 90 |
| 1975-08-13 | @ ATL | 118 | L 3-4 | 67-51 | 1 | 4,163 | Dock Ellis | Bruce Dal Canton | Tom House | Ken Brett | | 500 | 411 | 89 |
| 1975-08-14 | @ CIN | 119 | L 1-6 | 67-52 | 1 | 40,062 | Jerry Reuss | Gary Nolan | Gary Nolan | Jerry Reuss | | 501 | 417 | 84 |
| 1975-08-15 | @ CIN | 120 | L 3-8 | 67-53 | 1 | 45,003 | Jim Rooker | Fred Norman | Fred Norman | Jim Rooker | | 504 | 425 | 79 |
| 1975-08-16 | @ CIN | 121 | L 3-5 | 67-54 | 1 | 51,286 | John Candelaria | Jack Billingham | Jack Billingham | John Candelaria | Rawly Eastwick | 507 | 430 | 77 |
| 1975-08-17 | @ CIN | 122 | L 1-3 | 67-55 | 1 | 50,121 | Bruce Kison | Pat Darcy | Pat Darcy | Bruce Kison | Rawly Eastwick | 508 | 433 | 75 |
| 1975-08-19 | vs SFN | 123 | W 4-0 | 68-55 | 1 | 22,609 | Jerry Reuss | Jim Barr | Jerry Reuss | Jim Barr | | 512 | 433 | 79 |
| 1975-08-20 | vs SFN | 124 | W 3-1 | 69-55 | 1 | 14,033 | Jim Rooker | Ed Halicki | Jim Rooker | Ed Halicki | Dave Giusti | 515 | 434 | 81 |
| 1975-08-22 | vs CIN | 125 | W 7-2 | 71-55 | 1 | 0 | Larry Demery | Jack Billingham | Larry Demery | Jack Billingham | | 522 | 436 | 86 |
| 1975-08-22 | vs CIN | 126 | W 4-2 | 71-55 | 1 | 46,576 | John Candelaria | Pat Darcy | John Candelaria | Will McEnaney | Dave Giusti | 526 | 438 | 88 |
| 1975-08-23 | vs CIN | 127 | L 7-12 | 71-56 | 1 | 32,068 | Bruce Kison | Don Gullett | Clay Kirby | Bruce Kison | Rawly Eastwick | 533 | 450 | 83 |
| 1975-08-24 | vs CIN | 128 | W 5-1 | 72-56 | 1 | 35,598 | Jerry Reuss | Gary Nolan | Jerry Reuss | Gary Nolan | | 538 | 451 | 87 |
| 1975-08-25 | vs ATL | 129 | W 4-0 | 73-56 | 1 | 11,146 | Jim Rooker | Mike Thompson | Jim Rooker | Mike Thompson | | 542 | 451 | 91 |
| 1975-08-26 | vs ATL | 130 | W 8-2 | 74-56 | 1 | 12,213 | Larry Demery | Jamie Easterly | Larry Demery | Jamie Easterly | | 550 | 453 | 97 |
| 1975-08-27 | vs ATL | 131 | L 2-6 | 74-57 | 1 | 21,209 | John Candelaria | Phil Niekro | Phil Niekro | John Candelaria | | 552 | 459 | 93 |
| 1975-08-30 | vs HOU | 132 | L 4-7 | 74-58 | 1 | 13,473 | Jerry Reuss | Larry Dierker | Larry Dierker | Jerry Reuss | | 556 | 466 | 90 |
| 1975-08-31 | vs HOU | 133 | W 9-6 | 75-58 | 1 | 14,507 | Larry Demery | Dave Roberts | Bruce Kison | Jose Sosa | Dave Giusti | 565 | 472 | 93 |
| 1975-09-01 | @ NYN | 134 | L 0-3 | 75-59 | 1 | 45,991 | John Candelaria | Tom Seaver | Tom Seaver | John Candelaria | | 565 | 475 | 90 |
| 1975-09-02 | @ NYN | 135 | W 8-4 | 76-59 | 1 | 26,486 | Ken Brett | Jerry Koosman | Kent Tekulve | Jerry Koosman | Dave Giusti | 573 | 479 | 94 |
| 1975-09-03 | @ NYN | 136 | W 3-1 | 77-59 | 1 | 27,599 | Jerry Reuss | Jon Matlack | Jerry Reuss | Jon Matlack | | 576 | 480 | 96 |
| 1975-09-05 | @ MON | 137 | L 3-4 | 78-60 | 1 | 0 | Bruce Kison | Dan Warthen | Chuck Taylor | Kent Tekulve | | 579 | 484 | 95 |
| 1975-09-05 | @ MON | 138 | W 5-2 | 78-60 | 1 | 15,130 | Jim Rooker | Steve Renko | Jim Rooker | Steve Renko | Ramon Hernandez | 584 | 486 | 98 |
| 1975-09-06 | @ MON | 139 | W 12-5 | 79-60 | 1 | 10,206 | John Candelaria | Steve Rogers | Ken Brett | Dale Murray | | 596 | 491 | 105 |
| 1975-09-07 | @ MON | 140 | W 6-0 | 80-60 | 1 | 14,041 | Jerry Reuss | Dennis Blair | Jerry Reuss | Dennis Blair | | 602 | 491 | 111 |
| 1975-09-08 | vs CHN | 141 | W 4-1 | 81-60 | 1 | 6,756 | Dock Ellis | Willie Prall | Dock Ellis | Willie Prall | Ramon Hernandez | 606 | 492 | 114 |
| 1975-09-09 | vs CHN | 142 | L 5-6 | 81-61 | 1 | 7,346 | Bruce Kison | Bill Bonham | Bill Bonham | Larry Demery | Paul Reuschel | 611 | 498 | 113 |
| 1975-09-10 | vs NYN | 143 | W 8-4 | 82-61 | 1 | 11,988 | Jim Rooker | Tom Seaver | Jim Rooker | Tom Seaver | | 619 | 502 | 117 |
| 1975-09-11 | vs NYN | 144 | L 0-7 | 82-62 | 1 | 4,762 | Jerry Reuss | Jerry Koosman | Jerry Koosman | Jerry Reuss | | 619 | 509 | 110 |
| 1975-09-12 | vs MON | 145 | W 6-3 | 83-62 | 1 | 9,449 | John Candelaria | Don Carrithers | Bob Moose | Don Carrithers | | 625 | 512 | 113 |
| 1975-09-13 | vs MON | 146 | L 2-5 | 83-63 | 1 | 17,310 | Dock Ellis | Dan Warthen | Dan Warthen | Dock Ellis | Woodie Fryman | 627 | 517 | 110 |
| 1975-09-14 | vs MON | 147 | W 4-3 | 84-63 | 1 | 12,335 | Larry Demery | Dennis Blair | Ramon Hernandez | Woodie Fryman | Dave Giusti | 631 | 520 | 111 |
| 1975-09-15 | @ CHN | 148 | L 5-6 | 85-64 | 1 | 0 | Jerry Reuss | Bill Bonham | Darold Knowles | Dave Giusti | | 636 | 526 | 110 |
| 1975-09-15 | @ CHN | 149 | W 9-1 | 85-64 | 1 | 5,432 | Jim Rooker | Willie Prall | Jim Rooker | Willie Prall | | 645 | 527 | 118 |
| 1975-09-16 | @ CHN | 150 | W 22-0 | 86-64 | 1 | 4,932 | John Candelaria | Rick Reuschel | John Candelaria | Rick Reuschel | | 667 | 527 | 140 |
| 1975-09-17 | @ PHI | 151 | W 9-1 | 87-64 | 1 | 38,085 | Bruce Kison | Tom Underwood | Bruce Kison | Tom Underwood | | 676 | 528 | 148 |
| 1975-09-18 | @ PHI | 152 | L 1-4 | 87-65 | 1 | 27,093 | Dock Ellis | Steve Carlton | Steve Carlton | Dock Ellis | | 677 | 532 | 145 |
| 1975-09-19 | vs SLN | 153 | W 7-1 | 88-65 | 1 | 19,671 | Ken Brett | John Denny | Ken Brett | John Denny | | 684 | 533 | 151 |
| 1975-09-20 | vs SLN | 154 | L 2-8 | 88-66 | 1 | 13,493 | Jim Rooker | Eric Rasmussen | Eric Rasmussen | Jim Rooker | Al Hrabosky | 686 | 541 | 145 |
| 1975-09-21 | vs SLN | 155 | W 5-3 | 89-66 | 1 | 35,648 | Jerry Reuss | Bob Forsch | Jerry Reuss | Mike Garman | Kent Tekulve | 691 | 544 | 147 |
| 1975-09-22 | vs PHI | 156 | W 11-3 | 90-66 | 1 | 13,176 | Bruce Kison | Tom Underwood | Bruce Kison | Tom Underwood | Kent Tekulve | 702 | 547 | 155 |
| 1975-09-23 | vs PHI | 157 | W 3-1 | 91-66 | 1 | 6,445 | Bob Moose | Steve Carlton | Bob Moose | Steve Carlton | | 705 | 548 | 157 |
| 1975-09-24 | vs PHI | 158 | L 1-8 | 91-67 | 1 | 6,253 | Larry Demery | Larry Christenson | Larry Christenson | Larry Demery | | 706 | 556 | 150 |
| 1975-09-26 | @ SLN | 159 | L 0-1 | 91-68 | 1 | 23,496 | Jim Rooker | Bob Forsch | Bob Forsch | Jim Rooker | | 706 | 557 | 149 |
| 1975-09-27 | @ SLN | 160 | W 4-2 | 92-68 | 1 | 19,180 | Jerry Reuss | Lynn McGlothen | Jerry Reuss | Lynn McGlothen | Kent Tekulve | 710 | 559 | 151 |
| 1975-09-28 | @ SLN | 161 | L 2-6 | 92-69 | 1 | 20,909 | John Candelaria | Ron Reed | Ron Reed | John Candelaria | | 712 | 565 | 147 |