| 1975-04-08 | vs CHA | 1 | W 3-2 | 1-0 | 2 | 17,477 | Vida Blue | Wilbur Wood | Vida Blue | Wilbur Wood | Rollie Fingers | 3 | 2 | 1 |
| 1975-04-09 | vs CHA | 2 | L 5-7 | 1-1 | 4 | 4,543 | Ken Holtzman | Jim Kaat | Jim Kaat | Rollie Fingers | | 8 | 9 | -1 |
| 1975-04-10 | vs CHA | 3 | W 9-0 | 2-1 | 2 | 4,730 | Mike Norris | Stan Bahnsen | Mike Norris | Stan Bahnsen | | 17 | 9 | 8 |
| 1975-04-11 | @ TEX | 4 | W 7-5 | 3-1 | 1 | 14,979 | Glenn Abbott | Bill Hands | Paul Lindblad | Bill Hands | | 24 | 14 | 10 |
| 1975-04-12 | @ TEX | 5 | W 5-4 | 4-1 | 1 | 20,598 | Vida Blue | Fergie Jenkins | Vida Blue | Fergie Jenkins | Rollie Fingers | 29 | 18 | 11 |
| 1975-04-14 | @ KCA | 6 | W 3-2 | 5-1 | 1 | 8,219 | Ken Holtzman | Paul Splittorff | Ken Holtzman | Paul Splittorff | Rollie Fingers | 32 | 20 | 12 |
| 1975-04-15 | @ KCA | 7 | L 3-4 | 5-2 | 2 | 11,621 | Mike Norris | Al Fitzmorris | Al Fitzmorris | Rollie Fingers | | 35 | 24 | 11 |
| 1975-04-16 | @ KCA | 8 | L 2-6 | 5-3 | 2 | 13,080 | Vida Blue | Nelson Briles | Nelson Briles | Vida Blue | | 37 | 30 | 7 |
| 1975-04-18 | vs MIN | 9 | L 4-5 | 5-4 | 2 | 5,714 | Ken Holtzman | Vic Albury | Vic Albury | Ken Holtzman | Tom Burgmeier | 41 | 35 | 6 |
| 1975-04-19 | vs MIN | 10 | W 4-1 | 6-4 | 2 | 4,970 | Vida Blue | Ray Corbin | Vida Blue | Ray Corbin | Rollie Fingers | 45 | 36 | 9 |
| 1975-04-20 | vs MIN | 11 | W 4-1 | 8-4 | 2 | 0 | Glenn Abbott | Bert Blyleven | Glenn Abbott | Bert Blyleven | | 49 | 37 | 12 |
| 1975-04-20 | vs MIN | 12 | W 5-1 | 8-4 | 2 | 19,737 | Mike Norris | Jim Hughes | Dave Hamilton | Jim Hughes | Jim Todd | 54 | 38 | 16 |
| 1975-04-21 | vs TEX | 13 | W 11-6 | 9-4 | 2 | 25,865 | Blue Moon Odom | Jim Bibby | Paul Lindblad | Jim Bibby | | 65 | 44 | 21 |
| 1975-04-22 | vs TEX | 14 | L 1-2 | 9-5 | 2 | 2,607 | Ken Holtzman | Fergie Jenkins | Fergie Jenkins | Ken Holtzman | | 66 | 46 | 20 |
| 1975-04-23 | vs KCA | 15 | W 3-2 | 10-5 | 2 | 2,754 | Vida Blue | Steve Busby | Vida Blue | Steve Busby | Jim Todd | 69 | 48 | 21 |
| 1975-04-24 | vs KCA | 16 | W 3-2 | 11-5 | 1 | 3,112 | Glenn Abbott | Paul Splittorff | Glenn Abbott | Paul Splittorff | | 72 | 50 | 22 |
| 1975-04-25 | @ CAL | 17 | L 0-2 | 11-6 | 1 | 20,013 | Dave Hamilton | Andy Hassler | Andy Hassler | Dave Hamilton | | 72 | 52 | 20 |
| 1975-04-26 | @ CAL | 18 | L 0-1 | 11-7 | 2 | 26,188 | Ken Holtzman | Frank Tanana | Frank Tanana | Ken Holtzman | Don Kirkwood | 72 | 53 | 19 |
| 1975-04-27 | @ CAL | 19 | W 7-1 | 12-8 | 1 | 0 | Vida Blue | Bill Singer | Vida Blue | Bill Singer | | 79 | 54 | 25 |
| 1975-04-27 | @ CAL | 20 | L 1-9 | 12-8 | 1 | 26,584 | Blue Moon Odom | Ed Figueroa | Ed Figueroa | Blue Moon Odom | | 80 | 63 | 17 |
| 1975-05-02 | @ CHA | 21 | W 4-3 | 13-8 | 1 | 12,113 | Vida Blue | Wilbur Wood | Rollie Fingers | Terry Forster | Paul Lindblad | 84 | 66 | 18 |
| 1975-05-03 | @ CHA | 22 | L 3-4 | 13-9 | 1 | 17,874 | Ken Holtzman | Claude Osteen | Rich Gossage | Jim Todd | | 87 | 70 | 17 |
| 1975-05-04 | @ CHA | 23 | L 2-5 | 13-10 | 1 | 12,931 | Glenn Abbott | Jim Kaat | Jim Kaat | Glenn Abbott | Terry Forster | 89 | 75 | 14 |
| 1975-05-06 | vs CAL | 24 | W 5-3 | 14-10 | 1 | 5,210 | Ken Holtzman | Ed Figueroa | Paul Lindblad | Don Kirkwood | | 94 | 78 | 16 |
| 1975-05-07 | vs CAL | 25 | W 9-1 | 15-10 | 1 | 3,237 | Vida Blue | Bill Singer | Vida Blue | Bill Singer | | 103 | 79 | 24 |
| 1975-05-08 | vs CAL | 26 | L 0-5 | 15-11 | 1 | 3,598 | Dave Hamilton | Nolan Ryan | Nolan Ryan | Dave Hamilton | | 103 | 84 | 19 |
| 1975-05-09 | vs NYA | 27 | W 4-3 | 16-11 | 1 | 9,116 | Glenn Abbott | Pat Dobson | Rollie Fingers | Pat Dobson | | 107 | 87 | 20 |
| 1975-05-10 | vs NYA | 28 | L 0-3 | 16-12 | 1 | 23,942 | Ken Holtzman | Catfish Hunter | Catfish Hunter | Ken Holtzman | | 107 | 90 | 17 |
| 1975-05-11 | vs NYA | 29 | W 7-5 | 17-12 | 1 | 12,253 | Vida Blue | Rudy May | Vida Blue | Rudy May | Jim Todd | 114 | 95 | 19 |
| 1975-05-12 | vs BOS | 30 | W 5-3 | 18-12 | 1 | 28,984 | Dave Hamilton | Reggie Cleveland | Rollie Fingers | Diego Segui | Paul Lindblad | 119 | 98 | 21 |
| 1975-05-13 | vs BOS | 31 | W 9-5 | 19-12 | 1 | 4,239 | Glenn Abbott | Rick Wise | Ken Holtzman | Rick Wise | Jim Todd | 128 | 103 | 25 |
| 1975-05-16 | @ NYA | 32 | W 4-2 | 20-12 | 1 | 24,539 | Vida Blue | Pat Dobson | Vida Blue | Pat Dobson | | 132 | 105 | 27 |
| 1975-05-17 | @ NYA | 33 | W 6-1 | 21-12 | 1 | 23,063 | Ken Holtzman | Doc Medich | Ken Holtzman | Doc Medich | | 138 | 106 | 32 |
| 1975-05-18 | @ NYA | 34 | L 1-9 | 21-13 | 1 | 53,248 | Glenn Abbott | Catfish Hunter | Catfish Hunter | Glenn Abbott | | 139 | 115 | 24 |
| 1975-05-19 | @ BOS | 35 | L 5-10 | 21-14 | 1 | 14,700 | Dave Hamilton | Luis Tiant | Luis Tiant | Blue Moon Odom | | 144 | 125 | 19 |
| 1975-05-20 | @ BOS | 36 | L 0-7 | 21-15 | 1 | 17,201 | Vida Blue | Bill Lee | Bill Lee | Vida Blue | | 144 | 132 | 12 |
| 1975-05-21 | @ BOS | 37 | L 3-7 | 21-16 | 1 | 14,665 | Ken Holtzman | Reggie Cleveland | Reggie Cleveland | Ken Holtzman | | 147 | 139 | 8 |
| 1975-05-23 | @ CLE | 38 | W 3-0 | 22-16 | 1 | 15,608 | Sonny Siebert | Gaylord Perry | Sonny Siebert | Gaylord Perry | Jim Todd | 150 | 139 | 11 |
| 1975-05-24 | @ CLE | 39 | W 10-5 | 23-16 | 1 | 25,801 | Vida Blue | Eric Raich | Rollie Fingers | Don Hood | | 160 | 144 | 16 |
| 1975-05-25 | @ CLE | 40 | L 0-6 | 24-17 | 1 | 0 | Jim Perry | Dennis Eckersley | Dennis Eckersley | Jim Perry | | 160 | 150 | 10 |
| 1975-05-25 | @ CLE | 41 | W 6-3 | 24-17 | 1 | 48,978 | Dick Bosman | Jim Kern | Dick Bosman | Jim Kern | Jim Todd | 166 | 153 | 13 |
| 1975-05-26 | vs BAL | 42 | W 6-5 | 25-17 | 1 | 42,358 | Ken Holtzman | Mike Cuellar | Rollie Fingers | Doyle Alexander | | 172 | 158 | 14 |
| 1975-05-27 | vs BAL | 43 | W 4-2 | 26-17 | 1 | 4,234 | Sonny Siebert | Ross Grimsley | Jim Todd | Ross Grimsley | | 176 | 160 | 16 |
| 1975-05-28 | vs BAL | 44 | W 5-0 | 27-17 | 1 | 4,094 | Vida Blue | Mike Torrez | Vida Blue | Mike Torrez | | 181 | 160 | 21 |
| 1975-05-30 | vs CLE | 45 | W 6-2 | 28-17 | 1 | 7,554 | Dick Bosman | Jim Kern | Dick Bosman | Jim Kern | | 187 | 162 | 25 |
| 1975-05-31 | vs CLE | 46 | L 1-4 | 28-18 | 1 | 7,754 | Ken Holtzman | Dennis Eckersley | Dennis Eckersley | Ken Holtzman | | 188 | 166 | 22 |
| 1975-06-01 | vs CLE | 47 | W 6-3 | 29-18 | 1 | 7,644 | Sonny Siebert | Gaylord Perry | Sonny Siebert | Gaylord Perry | Rollie Fingers | 194 | 169 | 25 |
| 1975-06-02 | vs MIL | 48 | L 3-6 | 29-19 | 1 | 28,235 | Vida Blue | Ed Sprague | Bill Castro | Vida Blue | | 197 | 175 | 22 |
| 1975-06-03 | vs MIL | 49 | L 4-5 | 29-20 | 2 | 4,129 | Jim Perry | Bill Travers | Bill Champion | Jim Todd | Tom Murphy | 201 | 180 | 21 |
| 1975-06-04 | vs MIL | 50 | W 11-3 | 30-20 | 1 | 3,344 | Ken Holtzman | Pete Broberg | Ken Holtzman | Pete Broberg | | 212 | 183 | 29 |
| 1975-06-06 | vs DET | 51 | L 2-11 | 30-21 | 1 | 6,536 | Dick Bosman | Mickey Lolich | Mickey Lolich | Dick Bosman | John Hiller | 214 | 194 | 20 |
| 1975-06-07 | vs DET | 52 | L 0-3 | 30-22 | 1 | 34,953 | Vida Blue | Lerrin LaGrow | Lerrin LaGrow | Vida Blue | | 214 | 197 | 17 |
| 1975-06-08 | vs DET | 53 | W 4-0 | 31-22 | 1 | 9,780 | Ken Holtzman | Joe Coleman | Ken Holtzman | Joe Coleman | | 218 | 197 | 21 |
| 1975-06-09 | @ BAL | 54 | W 4-3 | 32-22 | 1 | 13,211 | Sonny Siebert | Mike Cuellar | Paul Lindblad | Dyar Miller | Vida Blue | 222 | 200 | 22 |
| 1975-06-10 | @ BAL | 55 | W 3-0 | 33-22 | 1 | 12,985 | Jim Perry | Ross Grimsley | Jim Perry | Ross Grimsley | | 225 | 200 | 25 |
| 1975-06-11 | @ MIL | 56 | W 5-3 | 34-22 | 1 | 15,382 | Dick Bosman | Jim Slaton | Dick Bosman | Jim Slaton | Rollie Fingers | 230 | 203 | 27 |
| 1975-06-12 | @ MIL | 57 | L 7-9 | 34-23 | 1 | 14,243 | Vida Blue | Bill Castro | Bill Castro | Vida Blue | | 237 | 212 | 25 |
| 1975-06-13 | @ DET | 58 | W 7-5 | 35-23 | 1 | 29,567 | Ken Holtzman | Joe Coleman | Paul Lindblad | Joe Coleman | Rollie Fingers | 244 | 217 | 27 |
| 1975-06-14 | @ DET | 59 | L 2-3 | 35-24 | 1 | 21,121 | Sonny Siebert | Tom Walker | Tom Walker | Sonny Siebert | John Hiller | 246 | 220 | 26 |
| 1975-06-16 | @ MIN | 60 | L 6-7 | 35-25 | 1 | 11,058 | Dick Bosman | Bill Campbell | Tom Burgmeier | Rollie Fingers | | 252 | 227 | 25 |
| 1975-06-17 | @ MIN | 61 | W 4-2 | 37-25 | 1 | 0 | Vida Blue | Dave Goltz | Vida Blue | Dave Goltz | | 256 | 229 | 27 |
| 1975-06-17 | @ MIN | 62 | W 8-7 | 37-25 | 1 | 16,752 | Ken Holtzman | Bill Butler | Ken Holtzman | Bill Butler | Jim Todd | 264 | 236 | 28 |
| 1975-06-18 | @ MIN | 63 | W 7-6 | 38-25 | 1 | 14,706 | Jim Perry | Vic Albury | Jim Todd | Vic Albury | Rollie Fingers | 271 | 242 | 29 |
| 1975-06-19 | @ MIN | 64 | W 5-2 | 39-25 | 1 | 12,206 | Sonny Siebert | Jim Hughes | Glenn Abbott | Jim Hughes | Paul Lindblad | 276 | 244 | 32 |
| 1975-06-20 | vs KCA | 65 | W 3-1 | 40-25 | 1 | 14,379 | Stan Bahnsen | Dennis Leonard | Stan Bahnsen | Dennis Leonard | Rollie Fingers | 279 | 245 | 34 |
| 1975-06-21 | vs KCA | 66 | L 1-4 | 40-26 | 1 | 11,505 | Ken Holtzman | Steve Busby | Steve Busby | Ken Holtzman | | 280 | 249 | 31 |
| 1975-06-22 | vs KCA | 67 | W 7-6 | 42-26 | 1 | 0 | Vida Blue | Al Fitzmorris | Jim Todd | Steve Mingori | | 287 | 255 | 32 |
| 1975-06-22 | vs KCA | 68 | W 8-1 | 42-26 | 1 | 29,698 | Dick Bosman | Marty Pattin | Dick Bosman | Marty Pattin | | 295 | 256 | 39 |
| 1975-06-23 | vs MIN | 69 | W 5-2 | 43-26 | 1 | 29,410 | Jim Perry | Jim Hughes | Paul Lindblad | Jim Hughes | | 300 | 258 | 42 |
| 1975-06-24 | vs MIN | 70 | W 6-4 | 44-26 | 1 | 4,826 | Stan Bahnsen | Joe Decker | Jim Todd | Joe Decker | | 306 | 262 | 44 |
| 1975-06-25 | vs MIN | 71 | W 7-1 | 45-26 | 1 | 4,723 | Ken Holtzman | Ray Corbin | Ken Holtzman | Ray Corbin | | 313 | 263 | 50 |
| 1975-06-27 | @ CAL | 72 | W 12-4 | 46-26 | 1 | 17,473 | Vida Blue | Andy Hassler | Vida Blue | Andy Hassler | | 325 | 267 | 58 |
| 1975-06-28 | @ CAL | 73 | W 10-4 | 47-26 | 1 | 26,465 | Dick Bosman | Bill Singer | Dick Bosman | Bill Singer | Paul Lindblad | 335 | 271 | 64 |
| 1975-06-29 | @ CAL | 74 | W 7-1 | 48-26 | 1 | 16,954 | Ken Holtzman | Nolan Ryan | Ken Holtzman | Nolan Ryan | Rollie Fingers | 342 | 272 | 70 |
| 1975-06-30 | @ CHA | 75 | L 1-6 | 48-27 | 1 | 21,536 | Stan Bahnsen | Wilbur Wood | Wilbur Wood | Stan Bahnsen | | 343 | 278 | 65 |
| 1975-07-01 | @ CHA | 76 | W 10-1 | 49-27 | 1 | 19,458 | Vida Blue | Jesse Jefferson | Vida Blue | Jesse Jefferson | | 353 | 279 | 74 |
| 1975-07-02 | @ CHA | 77 | L 4-5 | 49-28 | 1 | 16,750 | Jim Perry | Claude Osteen | Rich Gossage | Rollie Fingers | | 357 | 284 | 73 |
| 1975-07-03 | @ CHA | 78 | L 2-3 | 49-29 | 1 | 13,359 | Dick Bosman | Jim Kaat | Jim Kaat | Jim Todd | Rich Gossage | 359 | 287 | 72 |
| 1975-07-04 | vs CAL | 79 | W 6-0 | 50-29 | 1 | 40,879 | Ken Holtzman | Frank Tanana | Ken Holtzman | Frank Tanana | | 365 | 287 | 78 |
| 1975-07-05 | vs CAL | 80 | L 0-2 | 50-30 | 1 | 30,442 | Stan Bahnsen | Ed Figueroa | Ed Figueroa | Stan Bahnsen | | 365 | 289 | 76 |
| 1975-07-06 | vs CAL | 81 | L 0-2 | 50-31 | 1 | 9,234 | Vida Blue | Dick Lange | Dick Lange | Vida Blue | Don Kirkwood | 365 | 291 | 74 |
| 1975-07-07 | vs CLE | 82 | W 7-3 | 51-31 | 1 | 27,702 | Jim Perry | Dennis Eckersley | Jim Perry | Dennis Eckersley | | 372 | 294 | 78 |
| 1975-07-08 | vs CLE | 83 | W 15-5 | 52-31 | 1 | 4,041 | Ken Holtzman | Don Hood | Ken Holtzman | Don Hood | | 387 | 299 | 88 |
| 1975-07-09 | vs CLE | 84 | W 3-1 | 53-31 | 1 | 7,673 | Dick Bosman | Eric Raich | Dick Bosman | Eric Raich | Rollie Fingers | 390 | 300 | 90 |
| 1975-07-11 | vs BAL | 85 | L 0-4 | 53-32 | 1 | 11,718 | Vida Blue | Mike Torrez | Mike Torrez | Vida Blue | | 390 | 304 | 86 |
| 1975-07-12 | vs BAL | 86 | W 7-1 | 54-32 | 1 | 33,454 | Jim Perry | Jim Palmer | Jim Perry | Jim Palmer | | 397 | 305 | 92 |
| 1975-07-13 | vs BAL | 87 | W 4-3 | 55-32 | 1 | 11,550 | Ken Holtzman | Ross Grimsley | Ken Holtzman | Ross Grimsley | Rollie Fingers | 401 | 308 | 93 |
| 1975-07-17 | @ CLE | 88 | W 6-3 | 56-32 | 1 | 15,085 | Ken Holtzman | Eric Raich | Ken Holtzman | Eric Raich | Paul Lindblad | 407 | 311 | 96 |
| 1975-07-18 | @ CLE | 89 | W 7-6 | 57-32 | 1 | 33,251 | Stan Bahnsen | Jim Bibby | Glenn Abbott | Jim Bibby | Rollie Fingers | 414 | 317 | 97 |
| 1975-07-19 | @ BAL | 90 | L 2-3 | 57-34 | 1 | 0 | Vida Blue | Paul Mitchell | Paul Mitchell | Vida Blue | | 416 | 320 | 96 |
| 1975-07-19 | @ BAL | 91 | L 1-5 | 57-34 | 1 | 35,567 | Jim Perry | Ross Grimsley | Ross Grimsley | Jim Perry | Jim Palmer | 417 | 325 | 92 |
| 1975-07-20 | @ BAL | 92 | W 5-2 | 58-34 | 1 | 16,028 | Dick Bosman | Doyle Alexander | Rollie Fingers | Doyle Alexander | | 422 | 327 | 95 |
| 1975-07-21 | @ BAL | 93 | L 2-6 | 58-35 | 1 | 16,992 | Ken Holtzman | Mike Torrez | Mike Torrez | Ken Holtzman | Wayne Garland | 424 | 333 | 91 |
| 1975-07-22 | @ DET | 94 | W 11-0 | 60-35 | 1 | 0 | Glenn Abbott | Tom Walker | Glenn Abbott | Tom Walker | | 435 | 333 | 102 |
| 1975-07-22 | @ DET | 95 | W 16-4 | 60-35 | 1 | 29,089 | Stan Bahnsen | Lerrin LaGrow | Stan Bahnsen | Lerrin LaGrow | | 451 | 337 | 114 |
| 1975-07-23 | @ DET | 96 | W 3-0 | 61-35 | 1 | 20,251 | Vida Blue | Vern Ruhle | Vida Blue | Vern Ruhle | | 454 | 337 | 117 |
| 1975-07-24 | @ DET | 97 | L 2-5 | 61-36 | 1 | 14,255 | Jim Perry | Joe Coleman | Joe Coleman | Jim Perry | John Hiller | 456 | 342 | 114 |
| 1975-07-25 | vs CHA | 98 | W 8-6 | 62-36 | 1 | 10,500 | Ken Holtzman | Claude Osteen | Paul Lindblad | Cecil Upshaw | | 464 | 348 | 116 |
| 1975-07-26 | vs CHA | 99 | L 2-5 | 62-37 | 1 | 11,168 | Dick Bosman | Jim Kaat | Jim Kaat | Rollie Fingers | | 466 | 353 | 113 |
| 1975-07-27 | vs CHA | 100 | W 10-1 | 64-37 | 1 | 0 | Vida Blue | Jesse Jefferson | Vida Blue | Jesse Jefferson | | 476 | 354 | 122 |
| 1975-07-27 | vs CHA | 101 | W 7-1 | 64-37 | 1 | 21,254 | Stan Bahnsen | Lloyd Allen | Stan Bahnsen | Lloyd Allen | | 483 | 355 | 128 |
| 1975-07-28 | vs TEX | 102 | W 12-6 | 65-37 | 1 | 39,061 | Glenn Abbott | Bill Hands | Paul Lindblad | Tommy Moore | | 495 | 361 | 134 |
| 1975-07-29 | vs TEX | 103 | L 1-6 | 65-38 | 1 | 6,522 | Jim Perry | Steve Hargan | Steve Hargan | Jim Perry | | 496 | 367 | 129 |
| 1975-07-30 | vs TEX | 104 | W 1-0 | 66-38 | 1 | 6,631 | Ken Holtzman | Fergie Jenkins | Ken Holtzman | Fergie Jenkins | Paul Lindblad | 497 | 367 | 130 |
| 1975-08-01 | @ KCA | 105 | L 0-6 | 66-39 | 1 | 32,958 | Stan Bahnsen | Steve Busby | Steve Busby | Stan Bahnsen | | 497 | 373 | 124 |
| 1975-08-02 | @ KCA | 106 | W 6-5 | 67-39 | 1 | 39,333 | Vida Blue | Marty Pattin | Rollie Fingers | Steve Mingori | | 503 | 378 | 125 |
| 1975-08-03 | @ KCA | 107 | L 0-5 | 67-40 | 1 | 26,833 | Glenn Abbott | Paul Splittorff | Paul Splittorff | Glenn Abbott | | 503 | 383 | 120 |
| 1975-08-04 | @ TEX | 108 | L 0-12 | 67-41 | 1 | 14,668 | Ken Holtzman | Fergie Jenkins | Fergie Jenkins | Ken Holtzman | | 503 | 395 | 108 |
| 1975-08-05 | @ TEX | 109 | W 3-2 | 68-42 | 1 | 0 | Dick Bosman | Stan Perzanowski | Dick Bosman | Stan Perzanowski | Rollie Fingers | 506 | 397 | 109 |
| 1975-08-05 | @ TEX | 110 | L 2-15 | 68-42 | 1 | 22,380 | Sonny Siebert | Clyde Wright | Clyde Wright | Sonny Siebert | | 508 | 412 | 96 |
| 1975-08-06 | @ TEX | 111 | L 2-5 | 68-43 | 1 | 17,909 | Stan Bahnsen | Gaylord Perry | Gaylord Perry | Stan Bahnsen | | 510 | 417 | 93 |
| 1975-08-07 | @ TEX | 112 | W 10-1 | 69-43 | 1 | 20,373 | Vida Blue | Jim Umbarger | Vida Blue | Jim Umbarger | | 520 | 418 | 102 |
| 1975-08-08 | vs BOS | 113 | W 3-2 | 70-43 | 1 | 20,575 | Ken Holtzman | Reggie Cleveland | Ken Holtzman | Reggie Cleveland | Rollie Fingers | 523 | 420 | 103 |
| 1975-08-09 | vs BOS | 114 | L 2-7 | 70-44 | 1 | 16,828 | Sonny Siebert | Bill Lee | Bill Lee | Sonny Siebert | | 525 | 427 | 98 |
| 1975-08-10 | vs BOS | 115 | L 3-5 | 70-45 | 1 | 18,806 | Dick Bosman | Luis Tiant | Luis Tiant | Dick Bosman | Jim Willoughby | 528 | 432 | 96 |
| 1975-08-11 | vs BOS | 116 | W 4-3 | 71-45 | 1 | 46,376 | Vida Blue | Roger Moret | Vida Blue | Roger Moret | Jim Todd | 532 | 435 | 97 |
| 1975-08-12 | vs NYA | 117 | L 2-7 | 71-46 | 1 | 10,244 | Ken Holtzman | Doc Medich | Doc Medich | Ken Holtzman | | 534 | 442 | 92 |
| 1975-08-13 | vs NYA | 118 | L 1-3 | 71-47 | 1 | 17,326 | Stan Bahnsen | Catfish Hunter | Catfish Hunter | Stan Bahnsen | | 535 | 445 | 90 |
| 1975-08-14 | vs NYA | 119 | W 5-1 | 72-47 | 1 | 14,140 | Dick Bosman | Rudy May | Dick Bosman | Rudy May | | 540 | 446 | 94 |
| 1975-08-15 | vs MIL | 120 | L 4-8 | 72-48 | 1 | 7,279 | Vida Blue | Jim Colborn | Jim Colborn | Vida Blue | | 544 | 454 | 90 |
| 1975-08-16 | vs MIL | 121 | W 2-1 | 73-48 | 1 | 11,104 | Ken Holtzman | Jim Slaton | Rollie Fingers | Jim Slaton | | 546 | 455 | 91 |
| 1975-08-17 | vs MIL | 122 | W 3-1 | 74-48 | 1 | 9,436 | Stan Bahnsen | Pete Broberg | Stan Bahnsen | Pete Broberg | Rollie Fingers | 549 | 456 | 93 |
| 1975-08-18 | vs DET | 123 | L 3-5 | 74-49 | 1 | 24,488 | Vida Blue | Joe Coleman | Joe Coleman | Vida Blue | | 552 | 461 | 91 |
| 1975-08-19 | vs DET | 124 | L 1-3 | 74-50 | 1 | 5,016 | Dick Bosman | Mickey Lolich | Mickey Lolich | Dick Bosman | | 553 | 464 | 89 |
| 1975-08-20 | vs DET | 125 | W 2-1 | 75-50 | 1 | 6,255 | Sonny Siebert | Ray Bare | Sonny Siebert | Ray Bare | Jim Todd | 555 | 465 | 90 |
| 1975-08-21 | @ MIL | 126 | W 5-2 | 76-50 | 1 | 13,346 | Ken Holtzman | Pete Broberg | Ken Holtzman | Pete Broberg | | 560 | 467 | 93 |
| 1975-08-23 | @ MIL | 127 | W 6-3 | 78-50 | 1 | 0 | Glenn Abbott | Bill Travers | Jim Todd | Tom Murphy | Rollie Fingers | 566 | 470 | 96 |
| 1975-08-23 | @ MIL | 128 | W 9-3 | 78-50 | 1 | 21,036 | Stan Bahnsen | Tom Hausman | Stan Bahnsen | Tom Hausman | Jim Todd | 575 | 473 | 102 |
| 1975-08-24 | @ MIL | 129 | L 6-7 | 78-51 | 1 | 17,231 | Dick Bosman | Jim Colborn | Eduardo Rodriguez | Rollie Fingers | Tom Murphy | 581 | 480 | 101 |
| 1975-08-26 | @ NYA | 130 | L 1-7 | 78-52 | 1 | 20,927 | Sonny Siebert | Catfish Hunter | Catfish Hunter | Sonny Siebert | | 582 | 487 | 95 |
| 1975-08-27 | @ NYA | 131 | W 3-2 | 79-52 | 1 | 20,471 | Vida Blue | Doc Medich | Vida Blue | Doc Medich | Rollie Fingers | 585 | 489 | 96 |
| 1975-08-28 | @ NYA | 132 | L 2-3 | 79-53 | 1 | 16,477 | Ken Holtzman | Pat Dobson | Pat Dobson | Ken Holtzman | Tippy Martinez | 587 | 492 | 95 |
| 1975-08-29 | @ BOS | 133 | L 1-6 | 79-54 | 1 | 34,341 | Stan Bahnsen | Rick Wise | Rick Wise | Stan Bahnsen | | 588 | 498 | 90 |
| 1975-08-30 | @ BOS | 134 | W 7-6 | 80-54 | 1 | 28,171 | Glenn Abbott | Luis Tiant | Rollie Fingers | Dick Drago | | 595 | 504 | 91 |
| 1975-08-31 | @ BOS | 135 | W 8-6 | 81-54 | 1 | 32,753 | Sonny Siebert | Bill Lee | Rollie Fingers | Diego Segui | | 603 | 510 | 93 |
| 1975-09-01 | @ CAL | 136 | W 6-3 | 82-54 | 1 | 22,920 | Vida Blue | Ed Figueroa | Vida Blue | Ed Figueroa | | 609 | 513 | 96 |
| 1975-09-02 | @ CAL | 137 | L 1-4 | 82-55 | 1 | 10,952 | Ken Holtzman | Frank Tanana | Frank Tanana | Ken Holtzman | | 610 | 517 | 93 |
| 1975-09-05 | vs TEX | 138 | L 2-4 | 82-56 | 1 | 10,958 | Vida Blue | Gaylord Perry | Gaylord Perry | Vida Blue | | 612 | 521 | 91 |
| 1975-09-06 | vs TEX | 139 | W 2-1 | 83-56 | 1 | 7,624 | Stan Bahnsen | Fergie Jenkins | Paul Lindblad | Fergie Jenkins | Rollie Fingers | 614 | 522 | 92 |
| 1975-09-07 | vs TEX | 140 | W 4-1 | 85-56 | 1 | 0 | Dick Bosman | Clyde Wright | Dick Bosman | Clyde Wright | Jim Todd | 618 | 523 | 95 |
| 1975-09-07 | vs TEX | 141 | W 7-3 | 85-56 | 1 | 15,705 | Sonny Siebert | Steve Hargan | Sonny Siebert | Steve Hargan | Rollie Fingers | 625 | 526 | 99 |
| 1975-09-08 | vs KCA | 142 | W 8-2 | 86-56 | 1 | 38,735 | Ken Holtzman | Dennis Leonard | Ken Holtzman | Dennis Leonard | | 633 | 528 | 105 |
| 1975-09-09 | vs KCA | 143 | W 2-1 | 87-56 | 1 | 11,124 | Glenn Abbott | Paul Splittorff | Jim Todd | Marty Pattin | | 635 | 529 | 106 |
| 1975-09-10 | vs KCA | 144 | W 9-1 | 88-56 | 1 | 11,172 | Vida Blue | Steve Busby | Vida Blue | Steve Busby | | 644 | 530 | 114 |
| 1975-09-12 | @ MIN | 145 | W 11-4 | 89-57 | 1 | 0 | Dick Bosman | Jim Hughes | Dick Bosman | Jim Hughes | Jim Todd | 655 | 534 | 121 |
| 1975-09-12 | @ MIN | 146 | L 6-7 | 89-57 | 1 | 6,837 | Sonny Siebert | Eddie Bane | Eddie Bane | Paul Lindblad | Tom Burgmeier | 661 | 541 | 120 |
| 1975-09-13 | @ MIN | 147 | W 8-5 | 90-57 | 1 | 9,360 | Ken Holtzman | Dave Goltz | Ken Holtzman | Dave Goltz | Rollie Fingers | 669 | 546 | 123 |
| 1975-09-14 | @ MIN | 148 | L 8-10 | 90-58 | 1 | 22,772 | Glenn Abbott | Bill Butler | Bill Butler | Glenn Abbott | Tom Burgmeier | 677 | 556 | 121 |
| 1975-09-16 | @ TEX | 149 | W 11-5 | 92-58 | 1 | 0 | Vida Blue | Gaylord Perry | Jim Todd | Gaylord Perry | | 688 | 561 | 127 |
| 1975-09-16 | @ TEX | 150 | W 6-4 | 92-58 | 1 | 12,684 | Stan Bahnsen | Fergie Jenkins | Stan Bahnsen | Fergie Jenkins | Rollie Fingers | 694 | 565 | 129 |
| 1975-09-17 | @ CHA | 151 | L 2-3 | 92-59 | 1 | 4,761 | Ken Holtzman | Wilbur Wood | Wilbur Wood | Ken Holtzman | Dave Hamilton | 696 | 568 | 128 |
| 1975-09-18 | @ CHA | 152 | W 7-6 | 93-59 | 1 | 5,781 | Dick Bosman | Jim Kaat | Jim Todd | Jim Kaat | Rollie Fingers | 703 | 574 | 129 |
| 1975-09-19 | @ KCA | 153 | L 4-5 | 93-60 | 1 | 19,393 | Glenn Abbott | Steve Busby | Steve Busby | Glenn Abbott | Marty Pattin | 707 | 579 | 128 |
| 1975-09-20 | @ KCA | 154 | W 16-4 | 94-60 | 1 | 26,951 | Vida Blue | Paul Splittorff | Vida Blue | Paul Splittorff | | 723 | 583 | 140 |
| 1975-09-21 | @ KCA | 155 | L 1-2 | 94-61 | 1 | 21,023 | Dick Bosman | Dennis Leonard | Dennis Leonard | Dick Bosman | Marty Pattin | 724 | 585 | 139 |
| 1975-09-22 | vs MIN | 156 | L 1-2 | 94-62 | 1 | 20,497 | Ken Holtzman | Eddie Bane | Eddie Bane | Ken Holtzman | Tom Burgmeier | 725 | 587 | 138 |
| 1975-09-23 | vs MIN | 157 | L 3-4 | 94-63 | 1 | 3,979 | Stan Bahnsen | Bert Blyleven | Bert Blyleven | Stan Bahnsen | | 728 | 591 | 137 |
| 1975-09-24 | vs CHA | 158 | W 13-2 | 95-63 | 1 | 7,412 | Vida Blue | Jesse Jefferson | Vida Blue | Jesse Jefferson | | 741 | 593 | 148 |
| 1975-09-25 | vs CHA | 159 | L 2-8 | 95-64 | 1 | 2,663 | Craig Mitchell | Wilbur Wood | Wilbur Wood | Craig Mitchell | | 743 | 601 | 142 |
| 1975-09-26 | vs CAL | 160 | W 4-2 | 96-64 | 1 | 3,474 | Dick Bosman | Ed Figueroa | Dick Bosman | Ed Figueroa | Rollie Fingers | 747 | 603 | 144 |
| 1975-09-27 | vs CAL | 161 | W 6-3 | 97-64 | 1 | 5,177 | Ken Holtzman | Frank Tanana | Ken Holtzman | Frank Tanana | Paul Lindblad | 753 | 606 | 147 |
| 1975-09-28 | vs CAL | 162 | W 5-0 | 98-64 | 1 | 22,131 | Vida Blue | Gary Ross | Vida Blue | Gary Ross | | 758 | 606 | 152 |