| 1975-04-08 | @ CLE | 1 | L 3-5 | 0-1 | 6 | 56,715 | Doc Medich | Gaylord Perry | Gaylord Perry | Doc Medich | | 3 | 5 | -2 |
| 1975-04-11 | vs DET | 2 | L 3-5 | 0-2 | 6 | 26,212 | Catfish Hunter | Mickey Lolich | Mickey Lolich | Catfish Hunter | John Hiller | 6 | 10 | -4 |
| 1975-04-12 | vs DET | 3 | L 2-7 | 0-3 | 6 | 12,215 | Pat Dobson | Vern Ruhle | Vern Ruhle | Pat Dobson | | 8 | 17 | -9 |
| 1975-04-13 | vs DET | 4 | W 6-0 | 1-4 | 6 | 0 | Doc Medich | Tom Walker | Doc Medich | Tom Walker | | 14 | 17 | -3 |
| 1975-04-13 | vs DET | 5 | L 2-5 | 1-4 | 6 | 28,051 | Rudy May | Lerrin LaGrow | Lerrin LaGrow | Rudy May | | 16 | 22 | -6 |
| 1975-04-15 | vs BOS | 6 | L 3-5 | 1-5 | 6 | 7,773 | Catfish Hunter | Bill Lee | Bill Lee | Catfish Hunter | | 19 | 27 | -8 |
| 1975-04-16 | vs BOS | 7 | L 2-4 | 1-6 | 6 | 8,854 | Pat Dobson | Rick Wise | Rick Wise | Pat Dobson | | 21 | 31 | -10 |
| 1975-04-18 | @ DET | 8 | W 11-3 | 2-6 | 6 | 9,047 | Doc Medich | Joe Coleman | Doc Medich | Joe Coleman | | 32 | 34 | -2 |
| 1975-04-19 | @ DET | 9 | L 3-8 | 2-7 | 6 | 8,396 | Catfish Hunter | Mickey Lolich | Mickey Lolich | Catfish Hunter | | 35 | 42 | -7 |
| 1975-04-20 | @ DET | 10 | W 7-1 | 3-7 | 6 | 9,610 | Rudy May | Vern Ruhle | Rudy May | Vern Ruhle | | 42 | 43 | -1 |
| 1975-04-21 | @ BOS | 11 | W 12-1 | 4-7 | 6 | 28,381 | Pat Dobson | Bill Lee | Pat Dobson | Bill Lee | | 54 | 44 | 10 |
| 1975-04-22 | @ BOS | 12 | W 5-0 | 5-7 | 5 | 16,922 | Doc Medich | Rick Wise | Doc Medich | Rick Wise | | 59 | 44 | 15 |
| 1975-04-23 | @ BOS | 13 | L 7-11 | 5-8 | 6 | 22,243 | Catfish Hunter | Reggie Cleveland | Roger Moret | Sparky Lyle | Diego Segui | 66 | 55 | 11 |
| 1975-04-26 | vs MIL | 14 | W 10-1 | 6-8 | 6 | 11,767 | Pat Dobson | Jim Slaton | Pat Dobson | Jim Slaton | | 76 | 56 | 20 |
| 1975-04-27 | vs MIL | 15 | L 0-7 | 7-9 | 5 | 0 | Doc Medich | Pete Broberg | Pete Broberg | Doc Medich | | 76 | 63 | 13 |
| 1975-04-27 | vs MIL | 16 | W 10-1 | 7-9 | 5 | 41,493 | Catfish Hunter | Bill Champion | Catfish Hunter | Bill Champion | | 86 | 64 | 22 |
| 1975-04-28 | vs CLE | 17 | W 6-1 | 8-9 | 4 | 9,716 | Rudy May | Fritz Peterson | Rudy May | Fritz Peterson | | 92 | 65 | 27 |
| 1975-04-29 | vs CLE | 18 | L 1-3 | 8-10 | 5 | 6,320 | Larry Gura | Don Hood | Don Hood | Larry Gura | | 93 | 68 | 25 |
| 1975-04-30 | vs BAL | 19 | W 6-4 | 9-10 | 3 | 10,982 | Pat Dobson | Mike Torrez | Sparky Lyle | Grant Jackson | | 99 | 72 | 27 |
| 1975-05-01 | vs BAL | 20 | W 5-0 | 10-10 | 3 | 9,294 | Catfish Hunter | Jim Palmer | Catfish Hunter | Jim Palmer | | 104 | 72 | 32 |
| 1975-05-02 | @ MIL | 21 | L 2-4 | 10-11 | 3 | 14,838 | Doc Medich | Bill Champion | Bill Champion | Doc Medich | | 106 | 76 | 30 |
| 1975-05-03 | @ MIL | 22 | L 3-4 | 10-12 | 5 | 9,454 | Rudy May | Ed Sprague | Tom Murphy | Sparky Lyle | | 109 | 80 | 29 |
| 1975-05-04 | @ MIL | 23 | L 4-11 | 10-13 | 5 | 34,608 | Pat Dobson | Jim Slaton | Jim Slaton | Pat Dobson | | 113 | 91 | 22 |
| 1975-05-05 | @ BAL | 24 | L 1-3 | 10-14 | 5 | 13,591 | Catfish Hunter | Jim Palmer | Jim Palmer | Catfish Hunter | | 114 | 94 | 20 |
| 1975-05-07 | @ BAL | 25 | L 3-4 | 10-15 | 6 | 7,149 | Doc Medich | Mike Cuellar | Mike Cuellar | Doc Medich | | 117 | 98 | 19 |
| 1975-05-09 | @ OAK | 26 | L 3-4 | 10-16 | 6 | 9,116 | Pat Dobson | Glenn Abbott | Rollie Fingers | Pat Dobson | | 120 | 102 | 18 |
| 1975-05-10 | @ OAK | 27 | W 3-0 | 11-16 | 5 | 23,942 | Catfish Hunter | Ken Holtzman | Catfish Hunter | Ken Holtzman | | 123 | 102 | 21 |
| 1975-05-11 | @ OAK | 28 | L 5-7 | 11-17 | 6 | 12,253 | Rudy May | Vida Blue | Vida Blue | Rudy May | Jim Todd | 128 | 109 | 19 |
| 1975-05-13 | @ CAL | 29 | L 0-5 | 11-18 | 6 | 17,598 | Doc Medich | Nolan Ryan | Nolan Ryan | Doc Medich | | 128 | 114 | 14 |
| 1975-05-14 | @ CAL | 30 | W 4-3 | 12-18 | 6 | 16,921 | Catfish Hunter | Andy Hassler | Catfish Hunter | Andy Hassler | | 132 | 117 | 15 |
| 1975-05-16 | vs OAK | 31 | L 2-4 | 12-19 | 6 | 24,539 | Pat Dobson | Vida Blue | Vida Blue | Pat Dobson | | 134 | 121 | 13 |
| 1975-05-17 | vs OAK | 32 | L 1-6 | 12-20 | 6 | 23,063 | Doc Medich | Ken Holtzman | Ken Holtzman | Doc Medich | | 135 | 127 | 8 |
| 1975-05-18 | vs OAK | 33 | W 9-1 | 13-20 | 6 | 53,248 | Catfish Hunter | Glenn Abbott | Catfish Hunter | Glenn Abbott | | 144 | 128 | 16 |
| 1975-05-19 | vs KCA | 34 | W 5-1 | 14-20 | 5 | 8,654 | Rudy May | Steve Busby | Rudy May | Steve Busby | Dick Tidrow | 149 | 129 | 20 |
| 1975-05-20 | vs KCA | 35 | W 6-0 | 15-20 | 5 | 9,813 | Pat Dobson | Paul Splittorff | Pat Dobson | Paul Splittorff | | 155 | 129 | 26 |
| 1975-05-21 | vs KCA | 36 | L 1-4 | 15-21 | 5 | 11,101 | Doc Medich | Dennis Leonard | Doug Bird | Doc Medich | | 156 | 133 | 23 |
| 1975-05-23 | vs TEX | 37 | W 11-7 | 16-21 | 5 | 19,210 | Catfish Hunter | Fergie Jenkins | Catfish Hunter | Fergie Jenkins | | 167 | 140 | 27 |
| 1975-05-24 | vs TEX | 38 | W 9-5 | 17-21 | 4 | 15,659 | Rudy May | Clyde Wright | Dick Tidrow | Clyde Wright | Sparky Lyle | 176 | 145 | 31 |
| 1975-05-25 | vs TEX | 39 | W 5-4 | 18-21 | 4 | 23,084 | Pat Dobson | Jim Bibby | Pat Dobson | Jim Bibby | Sparky Lyle | 181 | 149 | 32 |
| 1975-05-26 | @ KCA | 40 | L 5-6 | 18-22 | 4 | 13,156 | Doc Medich | Dennis Leonard | Marty Pattin | Sparky Lyle | | 186 | 155 | 31 |
| 1975-05-27 | @ KCA | 41 | L 0-3 | 18-23 | 4 | 20,592 | Catfish Hunter | Al Fitzmorris | Al Fitzmorris | Catfish Hunter | | 186 | 158 | 28 |
| 1975-05-28 | @ KCA | 42 | W 6-2 | 19-23 | 4 | 10,108 | Rudy May | Nelson Briles | Rudy May | Nelson Briles | | 192 | 160 | 32 |
| 1975-05-29 | @ TEX | 43 | W 7-5 | 20-23 | 3 | 12,827 | Pat Dobson | Clyde Wright | Dick Tidrow | Jim Umbarger | | 199 | 165 | 34 |
| 1975-05-30 | @ TEX | 44 | L 5-6 | 20-24 | 4 | 16,887 | Doc Medich | Jim Bibby | Jackie Brown | Sparky Lyle | | 204 | 171 | 33 |
| 1975-05-31 | @ TEX | 45 | W 6-0 | 21-24 | 4 | 38,714 | Catfish Hunter | Bill Hands | Catfish Hunter | Bill Hands | | 210 | 171 | 39 |
| 1975-06-01 | @ TEX | 46 | W 8-4 | 22-24 | 2 | 15,866 | Rudy May | Fergie Jenkins | Rudy May | Fergie Jenkins | | 218 | 175 | 43 |
| 1975-06-03 | @ MIN | 47 | W 5-4 | 23-24 | 3 | 10,184 | Pat Dobson | Dave Goltz | Pat Dobson | Dave Goltz | Sparky Lyle | 223 | 179 | 44 |
| 1975-06-04 | @ MIN | 48 | W 6-3 | 24-24 | 2 | 9,161 | Doc Medich | Bert Blyleven | Doc Medich | Bert Blyleven | Dick Tidrow | 229 | 182 | 47 |
| 1975-06-05 | @ MIN | 49 | W 7-4 | 25-24 | 2 | 11,721 | Catfish Hunter | Jim Hughes | Catfish Hunter | Jim Hughes | | 236 | 186 | 50 |
| 1975-06-06 | @ CHA | 50 | W 5-1 | 26-24 | 2 | 17,159 | Rudy May | Wilbur Wood | Rudy May | Wilbur Wood | | 241 | 187 | 54 |
| 1975-06-07 | @ CHA | 51 | W 6-3 | 27-24 | 2 | 22,242 | Pat Dobson | Stan Bahnsen | Pat Dobson | Stan Bahnsen | | 247 | 190 | 57 |
| 1975-06-08 | @ CHA | 52 | W 4-1 | 28-24 | 2 | 13,423 | Doc Medich | Jim Kaat | Doc Medich | Jim Kaat | Sparky Lyle | 251 | 191 | 60 |
| 1975-06-09 | vs CAL | 53 | L 3-5 | 28-25 | 2 | 22,905 | Catfish Hunter | Bill Singer | Bill Singer | Catfish Hunter | | 254 | 196 | 58 |
| 1975-06-10 | vs CAL | 54 | W 6-4 | 29-25 | 2 | 31,809 | Larry Gura | Nolan Ryan | Larry Gura | Nolan Ryan | Dick Tidrow | 260 | 200 | 60 |
| 1975-06-11 | vs MIN | 55 | W 5-1 | 30-25 | 2 | 13,659 | Rudy May | Mike Pazik | Rudy May | Mike Pazik | | 265 | 201 | 64 |
| 1975-06-13 | vs CHA | 56 | W 2-1 | 31-25 | 2 | 26,485 | Pat Dobson | Claude Osteen | Pat Dobson | Claude Osteen | | 267 | 202 | 65 |
| 1975-06-14 | vs CHA | 57 | L 2-7 | 31-26 | 2 | 31,120 | Doc Medich | Wilbur Wood | Wilbur Wood | Doc Medich | | 269 | 209 | 60 |
| 1975-06-15 | vs CHA | 58 | W 3-0 | 32-26 | 2 | 53,562 | Catfish Hunter | Stan Bahnsen | Catfish Hunter | Stan Bahnsen | | 272 | 209 | 63 |
| 1975-06-16 | vs MIL | 59 | W 10-7 | 33-26 | 2 | 10,901 | Rudy May | Pete Broberg | Dick Tidrow | Ed Sprague | Sparky Lyle | 282 | 216 | 66 |
| 1975-06-17 | vs MIL | 60 | L 3-4 | 34-27 | 2 | 0 | Pat Dobson | Bill Castro | Bill Castro | Sparky Lyle | Tom Murphy | 285 | 220 | 65 |
| 1975-06-17 | vs MIL | 61 | W 4-2 | 34-27 | 2 | 19,724 | Larry Gura | Jim Colborn | Dick Tidrow | Jim Colborn | | 289 | 222 | 67 |
| 1975-06-18 | vs MIL | 62 | L 3-5 | 34-28 | 2 | 15,273 | Doc Medich | Bill Travers | Bill Travers | Doc Medich | Eduardo Rodriguez | 292 | 227 | 65 |
| 1975-06-19 | @ DET | 63 | W 9-2 | 35-28 | 2 | 14,271 | Catfish Hunter | Ray Bare | Catfish Hunter | Ray Bare | | 301 | 229 | 72 |
| 1975-06-20 | @ DET | 64 | L 9-10 | 35-29 | 2 | 23,347 | Rudy May | Vern Ruhle | Vern Ruhle | Rudy May | | 310 | 239 | 71 |
| 1975-06-21 | @ DET | 65 | W 4-1 | 36-29 | 2 | 19,780 | Pat Dobson | Mickey Lolich | Pat Dobson | Mickey Lolich | | 314 | 240 | 74 |
| 1975-06-22 | @ DET | 66 | W 5-3 | 37-29 | 2 | 31,077 | Larry Gura | Tom Walker | Larry Gura | Tom Walker | Dick Tidrow | 319 | 243 | 76 |
| 1975-06-23 | @ BAL | 67 | W 6-1 | 38-29 | 2 | 15,237 | Doc Medich | Ross Grimsley | Doc Medich | Ross Grimsley | | 325 | 244 | 81 |
| 1975-06-24 | @ BAL | 68 | W 3-1 | 39-29 | 1 | 19,175 | Catfish Hunter | Mike Torrez | Catfish Hunter | Mike Torrez | | 328 | 245 | 83 |
| 1975-06-25 | @ BAL | 69 | W 2-1 | 40-29 | 1 | 18,601 | Rudy May | Jim Palmer | Sparky Lyle | Jim Palmer | | 330 | 246 | 84 |
| 1975-06-26 | @ BOS | 70 | L 1-6 | 40-30 | 1 | 34,293 | Pat Dobson | Luis Tiant | Luis Tiant | Pat Dobson | | 331 | 252 | 79 |
| 1975-06-27 | @ BOS | 71 | L 1-9 | 40-31 | 2 | 35,489 | Larry Gura | Rick Wise | Rick Wise | Larry Gura | | 332 | 261 | 71 |
| 1975-06-28 | @ BOS | 72 | W 8-6 | 41-31 | 1 | 32,631 | Doc Medich | Bill Lee | Dick Tidrow | Reggie Cleveland | | 340 | 267 | 73 |
| 1975-06-29 | @ BOS | 73 | L 2-3 | 41-32 | 2 | 33,752 | Catfish Hunter | Roger Moret | Roger Moret | Catfish Hunter | | 342 | 270 | 72 |
| 1975-06-30 | @ MIL | 74 | L 4-5 | 41-33 | 2 | 16,156 | Rudy May | Bill Travers | Bill Travers | Rudy May | | 346 | 275 | 71 |
| 1975-07-01 | @ MIL | 75 | L 3-6 | 41-34 | 3 | 20,938 | Pat Dobson | Jim Colborn | Jim Colborn | Pat Dobson | Rick Austin | 349 | 281 | 68 |
| 1975-07-02 | @ CLE | 76 | L 2-3 | 41-35 | 3 | 15,100 | Larry Gura | Dennis Eckersley | Dave LaRoche | Dick Tidrow | | 351 | 284 | 67 |
| 1975-07-03 | @ CLE | 77 | L 2-3 | 41-36 | 3 | 14,189 | Doc Medich | Don Hood | Don Hood | Doc Medich | Dave LaRoche | 353 | 287 | 66 |
| 1975-07-04 | vs BAL | 78 | L 4-5 | 41-37 | 3 | 19,865 | Catfish Hunter | Jim Palmer | Jim Palmer | Catfish Hunter | Grant Jackson | 357 | 292 | 65 |
| 1975-07-05 | vs BAL | 79 | L 2-5 | 41-38 | 3 | 26,351 | Rudy May | Ross Grimsley | Ross Grimsley | Rudy May | | 359 | 297 | 62 |
| 1975-07-06 | vs BAL | 80 | W 6-1 | 42-38 | 2 | 35,284 | Pat Dobson | Mike Cuellar | Pat Dobson | Mike Cuellar | | 365 | 298 | 67 |
| 1975-07-07 | vs TEX | 81 | W 5-2 | 43-38 | 2 | 10,625 | Doc Medich | Bill Hands | Doc Medich | Bill Hands | | 370 | 300 | 70 |
| 1975-07-08 | vs TEX | 82 | W 4-0 | 44-38 | 2 | 16,020 | Catfish Hunter | Steve Hargan | Catfish Hunter | Steve Hargan | | 374 | 300 | 74 |
| 1975-07-09 | vs TEX | 83 | L 0-4 | 44-39 | 2 | 10,779 | Rudy May | Fergie Jenkins | Fergie Jenkins | Rudy May | | 374 | 304 | 70 |
| 1975-07-10 | vs MIN | 84 | L 3-6 | 44-40 | 3 | 12,556 | Pat Dobson | Ray Corbin | Ray Corbin | Pat Dobson | Tom Johnson | 377 | 310 | 67 |
| 1975-07-11 | vs MIN | 85 | L 1-11 | 45-41 | 3 | 0 | Doc Medich | Bert Blyleven | Bert Blyleven | Doc Medich | | 378 | 321 | 57 |
| 1975-07-11 | vs MIN | 86 | W 4-3 | 45-41 | 3 | 21,355 | Larry Gura | Mark Wiley | Larry Gura | Mark Wiley | | 382 | 324 | 58 |
| 1975-07-12 | vs MIN | 87 | W 8-7 | 46-41 | 3 | 13,573 | Catfish Hunter | Jim Hughes | Tippy Martinez | Tom Burgmeier | | 390 | 331 | 59 |
| 1975-07-17 | @ TEX | 88 | L 2-7 | 46-42 | 2 | 18,025 | Pat Dobson | Fergie Jenkins | Fergie Jenkins | Pat Dobson | | 392 | 338 | 54 |
| 1975-07-18 | @ TEX | 89 | L 0-1 | 46-43 | 3 | 24,576 | Catfish Hunter | Gaylord Perry | Gaylord Perry | Catfish Hunter | | 392 | 339 | 53 |
| 1975-07-19 | @ MIN | 90 | L 1-2 | 46-44 | 3 | 37,602 | Doc Medich | Jim Hughes | Jim Hughes | Doc Medich | Tom Burgmeier | 393 | 341 | 52 |
| 1975-07-20 | @ MIN | 91 | W 14-2 | 48-44 | 2 | 0 | Rudy May | Ray Corbin | Rudy May | Ray Corbin | | 407 | 343 | 64 |
| 1975-07-20 | @ MIN | 92 | W 5-4 | 48-44 | 2 | 23,782 | Larry Gura | Vic Albury | Dick Tidrow | Bill Campbell | | 412 | 347 | 65 |
| 1975-07-21 | @ MIN | 93 | L 0-3 | 48-45 | 2 | 12,475 | Pat Dobson | Bert Blyleven | Bert Blyleven | Pat Dobson | | 412 | 350 | 62 |
| 1975-07-22 | @ CHA | 94 | W 11-6 | 49-45 | 2 | 17,395 | Catfish Hunter | Jim Kaat | Catfish Hunter | Jim Kaat | Tippy Martinez | 423 | 356 | 67 |
| 1975-07-24 | @ CHA | 95 | L 3-4 | 49-47 | 3 | 0 | Doc Medich | Wilbur Wood | Rich Gossage | Dick Tidrow | | 426 | 360 | 66 |
| 1975-07-24 | @ CHA | 96 | L 0-1 | 49-47 | 3 | 13,910 | Larry Gura | Jesse Jefferson | Dave Hamilton | Larry Gura | | 426 | 361 | 65 |
| 1975-07-25 | vs BOS | 97 | W 8-6 | 50-47 | 2 | 40,165 | Rudy May | Luis Tiant | Rudy May | Luis Tiant | Tippy Martinez | 434 | 367 | 67 |
| 1975-07-26 | vs BOS | 98 | L 2-4 | 50-48 | 3 | 37,387 | Pat Dobson | Reggie Cleveland | Reggie Cleveland | Pat Dobson | Jim Willoughby | 436 | 371 | 65 |
| 1975-07-27 | vs BOS | 99 | L 0-1 | 50-50 | 3 | 0 | Catfish Hunter | Bill Lee | Bill Lee | Catfish Hunter | | 436 | 372 | 64 |
| 1975-07-27 | vs BOS | 100 | L 0-6 | 50-50 | 3 | 53,631 | Tippy Martinez | Roger Moret | Roger Moret | Tippy Martinez | | 436 | 378 | 58 |
| 1975-07-28 | vs DET | 101 | L 0-3 | 50-51 | 3 | 11,244 | Larry Gura | Vern Ruhle | Vern Ruhle | Larry Gura | | 436 | 381 | 55 |
| 1975-07-29 | vs DET | 102 | W 4-2 | 51-51 | 3 | 13,410 | Doc Medich | Joe Coleman | Doc Medich | Joe Coleman | Tippy Martinez | 440 | 383 | 57 |
| 1975-07-30 | vs DET | 103 | W 2-1 | 52-51 | 3 | 12,591 | Rudy May | Mickey Lolich | Rudy May | Mickey Lolich | | 442 | 384 | 58 |
| 1975-08-01 | vs CLE | 104 | W 5-4 | 53-51 | 3 | 15,841 | Catfish Hunter | Eric Raich | Catfish Hunter | Eric Raich | Dick Tidrow | 447 | 388 | 59 |
| 1975-08-02 | vs CLE | 105 | W 5-3 | 54-51 | 3 | 43,968 | Pat Dobson | Fritz Peterson | Sparky Lyle | Jim Bibby | | 452 | 391 | 61 |
| 1975-08-03 | vs CLE | 106 | W 12-1 | 55-52 | 3 | 0 | Doc Medich | Roric Harrison | Doc Medich | Roric Harrison | | 464 | 392 | 72 |
| 1975-08-03 | vs CLE | 107 | L 2-3 | 55-52 | 3 | 21,083 | Larry Gura | Don Hood | Don Hood | Dick Tidrow | Dave LaRoche | 466 | 395 | 71 |
| 1975-08-04 | @ MIL | 108 | W 2-1 | 56-52 | 3 | 13,544 | Rudy May | Bill Travers | Rudy May | Bill Travers | | 468 | 396 | 72 |
| 1975-08-05 | @ MIL | 109 | W 4-3 | 57-52 | 3 | 18,898 | Catfish Hunter | Tom Hausman | Catfish Hunter | Tom Murphy | | 472 | 399 | 73 |
| 1975-08-06 | @ CLE | 110 | L 3-5 | 57-53 | 3 | 12,343 | Pat Dobson | Fritz Peterson | Fritz Peterson | Pat Dobson | Dave LaRoche | 475 | 404 | 71 |
| 1975-08-07 | @ CLE | 111 | W 6-3 | 58-53 | 3 | 11,124 | Doc Medich | Don Hood | Doc Medich | Don Hood | Sparky Lyle | 481 | 407 | 74 |
| 1975-08-08 | @ CAL | 112 | W 4-3 | 59-53 | 3 | 12,176 | Larry Gura | Nolan Ryan | Larry Gura | Nolan Ryan | | 485 | 410 | 75 |
| 1975-08-09 | @ CAL | 113 | L 1-8 | 59-54 | 3 | 15,779 | Catfish Hunter | Ed Figueroa | Ed Figueroa | Catfish Hunter | | 486 | 418 | 68 |
| 1975-08-10 | @ CAL | 114 | L 0-1 | 59-55 | 3 | 11,682 | Rudy May | Bill Singer | Mickey Scott | Rudy May | | 486 | 419 | 67 |
| 1975-08-11 | @ CAL | 115 | L 1-8 | 59-56 | 3 | 9,491 | Pat Dobson | Frank Tanana | Frank Tanana | Pat Dobson | | 487 | 427 | 60 |
| 1975-08-12 | @ OAK | 116 | W 7-2 | 60-56 | 3 | 10,244 | Doc Medich | Ken Holtzman | Doc Medich | Ken Holtzman | | 494 | 429 | 65 |
| 1975-08-13 | @ OAK | 117 | W 3-1 | 61-56 | 3 | 17,326 | Catfish Hunter | Stan Bahnsen | Catfish Hunter | Stan Bahnsen | | 497 | 430 | 67 |
| 1975-08-14 | @ OAK | 118 | L 1-5 | 61-57 | 3 | 14,140 | Rudy May | Dick Bosman | Dick Bosman | Rudy May | | 498 | 435 | 63 |
| 1975-08-15 | @ KCA | 119 | W 5-4 | 62-57 | 3 | 27,099 | Pat Dobson | Dennis Leonard | Pat Dobson | Doug Bird | Tippy Martinez | 503 | 439 | 64 |
| 1975-08-16 | @ KCA | 120 | L 3-4 | 62-58 | 3 | 32,913 | Doc Medich | Steve Busby | Nelson Briles | Doc Medich | Bob McClure | 506 | 443 | 63 |
| 1975-08-17 | @ KCA | 121 | L 3-5 | 62-59 | 3 | 31,260 | Catfish Hunter | Paul Splittorff | Paul Splittorff | Catfish Hunter | | 509 | 448 | 61 |
| 1975-08-19 | vs CHA | 122 | L 6-7 | 62-60 | 3 | 12,738 | Larry Gura | Jesse Jefferson | Dave Hamilton | Sparky Lyle | | 515 | 455 | 60 |
| 1975-08-20 | vs CHA | 123 | L 3-5 | 62-61 | 3 | 12,304 | Rudy May | Wilbur Wood | Wilbur Wood | Rudy May | | 518 | 460 | 58 |
| 1975-08-21 | vs CHA | 124 | L 1-2 | 62-62 | 3 | 10,012 | Doc Medich | Jim Kaat | Jim Kaat | Doc Medich | Rich Gossage | 519 | 462 | 57 |
| 1975-08-22 | vs CAL | 125 | W 5-2 | 63-62 | 3 | 15,300 | Catfish Hunter | Ed Figueroa | Catfish Hunter | Ed Figueroa | | 524 | 464 | 60 |
| 1975-08-23 | vs CAL | 126 | W 12-4 | 64-62 | 3 | 15,509 | Larry Gura | Bill Singer | Larry Gura | Bill Singer | | 536 | 468 | 68 |
| 1975-08-24 | vs CAL | 127 | L 0-9 | 64-64 | 3 | 0 | Rudy May | Frank Tanana | Frank Tanana | Rudy May | | 536 | 477 | 59 |
| 1975-08-24 | vs CAL | 128 | L 3-4 | 64-64 | 3 | 30,656 | Tippy Martinez | Nolan Ryan | Nolan Ryan | Tippy Martinez | Jim Brewer | 539 | 481 | 58 |
| 1975-08-26 | vs OAK | 129 | W 7-1 | 65-64 | 3 | 20,927 | Catfish Hunter | Sonny Siebert | Catfish Hunter | Sonny Siebert | | 546 | 482 | 64 |
| 1975-08-27 | vs OAK | 130 | L 2-3 | 65-65 | 3 | 20,471 | Doc Medich | Vida Blue | Vida Blue | Doc Medich | Rollie Fingers | 548 | 485 | 63 |
| 1975-08-28 | vs OAK | 131 | W 3-2 | 66-65 | 3 | 16,477 | Pat Dobson | Ken Holtzman | Pat Dobson | Ken Holtzman | Tippy Martinez | 551 | 487 | 64 |
| 1975-08-29 | vs KCA | 132 | W 6-5 | 67-65 | 3 | 11,345 | Rudy May | Al Fitzmorris | Sparky Lyle | Marty Pattin | | 557 | 492 | 65 |
| 1975-08-30 | vs KCA | 133 | L 2-5 | 67-66 | 3 | 9,926 | Catfish Hunter | Dennis Leonard | Dennis Leonard | Catfish Hunter | | 559 | 497 | 62 |
| 1975-08-31 | vs KCA | 134 | L 0-7 | 67-67 | 3 | 15,563 | Larry Gura | Paul Splittorff | Paul Splittorff | Larry Gura | | 559 | 504 | 55 |
| 1975-09-01 | @ BOS | 135 | W 4-2 | 68-67 | 3 | 30,218 | Doc Medich | Roger Moret | Doc Medich | Roger Moret | Tippy Martinez | 563 | 506 | 57 |
| 1975-09-02 | @ BOS | 136 | L 4-7 | 68-68 | 3 | 28,598 | Pat Dobson | Reggie Cleveland | Reggie Cleveland | Pat Dobson | Dick Drago | 567 | 513 | 54 |
| 1975-09-03 | @ DET | 137 | W 8-0 | 69-68 | 3 | 6,581 | Catfish Hunter | Mickey Lolich | Catfish Hunter | Mickey Lolich | | 575 | 513 | 62 |
| 1975-09-04 | @ DET | 138 | W 8-1 | 70-68 | 3 | 6,341 | Rudy May | Ray Bare | Rudy May | Ray Bare | | 583 | 514 | 69 |
| 1975-09-05 | @ BAL | 139 | L 4-5 | 70-70 | 3 | 0 | Doc Medich | Wayne Garland | Paul Mitchell | Doc Medich | | 587 | 519 | 68 |
| 1975-09-05 | @ BAL | 140 | L 1-2 | 70-70 | 3 | 15,159 | Larry Gura | Ross Grimsley | Ross Grimsley | Larry Gura | | 588 | 521 | 67 |
| 1975-09-06 | @ BAL | 141 | L 6-7 | 70-71 | 3 | 19,236 | Pat Dobson | Mike Cuellar | Grant Jackson | Sparky Lyle | | 594 | 528 | 66 |
| 1975-09-07 | @ BAL | 142 | W 2-0 | 71-71 | 3 | 28,308 | Catfish Hunter | Jim Palmer | Catfish Hunter | Jim Palmer | | 596 | 528 | 68 |
| 1975-09-08 | vs DET | 143 | W 3-0 | 72-71 | 3 | 6,944 | Rudy May | Mickey Lolich | Rudy May | Mickey Lolich | | 599 | 528 | 71 |
| 1975-09-09 | vs DET | 144 | W 9-6 | 73-71 | 3 | 7,240 | Doc Medich | Ray Bare | Doc Medich | Ray Bare | Tippy Martinez | 608 | 534 | 74 |
| 1975-09-10 | vs MIL | 145 | W 8-2 | 74-71 | 3 | 6,944 | Larry Gura | Pat Osburn | Larry Gura | Pat Osburn | | 616 | 536 | 80 |
| 1975-09-11 | vs MIL | 146 | W 10-2 | 75-71 | 3 | 7,352 | Catfish Hunter | Jim Colborn | Catfish Hunter | Jim Colborn | | 626 | 538 | 88 |
| 1975-09-13 | vs CLE | 147 | L 1-7 | 76-72 | 3 | 0 | Rudy May | Fritz Peterson | Fritz Peterson | Rudy May | | 627 | 545 | 82 |
| 1975-09-13 | vs CLE | 148 | W 4-3 | 76-72 | 3 | 8,324 | Doc Medich | Jim Bibby | Doc Medich | Jim Bibby | Tippy Martinez | 631 | 548 | 83 |
| 1975-09-14 | vs CLE | 149 | W 6-2 | 77-72 | 3 | 15,125 | Catfish Hunter | Rick Waits | Catfish Hunter | Rick Waits | | 637 | 550 | 87 |
| 1975-09-16 | @ MIL | 150 | L 2-5 | 77-73 | 3 | 4,882 | Larry Gura | Jerry Augustine | Jerry Augustine | Larry Gura | Tom Murphy | 639 | 555 | 84 |
| 1975-09-17 | @ MIL | 151 | W 6-5 | 78-73 | 3 | 4,447 | Doc Medich | Pete Broberg | Sparky Lyle | Pete Broberg | | 645 | 560 | 85 |
| 1975-09-19 | @ CLE | 152 | L 2-3 | 78-74 | 3 | 9,388 | Catfish Hunter | Fritz Peterson | Fritz Peterson | Catfish Hunter | Dave LaRoche | 647 | 563 | 84 |
| 1975-09-20 | @ CLE | 153 | W 4-1 | 79-74 | 3 | 10,359 | Rudy May | Don Hood | Rudy May | Don Hood | Dave Pagan | 651 | 564 | 87 |
| 1975-09-21 | @ CLE | 154 | L 2-3 | 80-75 | 3 | 0 | Larry Gura | Rick Waits | Rick Waits | Larry Gura | Dave LaRoche | 653 | 567 | 86 |
| 1975-09-21 | @ CLE | 155 | W 11-5 | 80-75 | 3 | 21,149 | Doc Medich | Dennis Eckersley | Doc Medich | Dennis Eckersley | | 664 | 572 | 92 |
| 1975-09-22 | vs BOS | 156 | L 4-6 | 80-76 | 3 | 10,622 | Ron Guidry | Rick Wise | Rick Wise | Ron Guidry | Dick Drago | 668 | 578 | 90 |
| 1975-09-27 | vs BAL | 157 | W 3-2 | 82-76 | 3 | 0 | Catfish Hunter | Mike Torrez | Catfish Hunter | Mike Torrez | | 671 | 580 | 91 |
| 1975-09-27 | vs BAL | 158 | W 7-3 | 82-76 | 3 | 11,654 | Doc Medich | Mike Cuellar | Doc Medich | Mike Cuellar | | 678 | 583 | 95 |
| 1975-09-28 | vs BAL | 159 | L 0-3 | 83-77 | 3 | 0 | Rudy May | Jim Palmer | Jim Palmer | Rudy May | | 678 | 586 | 92 |
| 1975-09-28 | vs BAL | 160 | W 3-2 | 83-77 | 3 | 20,399 | Larry Gura | Mike Flanagan | Larry Gura | Mike Flanagan | | 681 | 588 | 93 |