| 1975-04-08 | @ TEX | 1 | W 11-4 | 1-0 | 1 | 28,787 | Bert Blyleven | Fergie Jenkins | Bert Blyleven | Fergie Jenkins | Bill Campbell | 11 | 4 | 7 |
| 1975-04-09 | @ TEX | 2 | W 3-2 | 2-0 | 1 | 6,149 | Joe Decker | Jim Bibby | Joe Decker | Jim Bibby | Tom Burgmeier | 14 | 6 | 8 |
| 1975-04-10 | @ TEX | 3 | L 4-5 | 2-1 | 1 | 5,066 | Dave Goltz | Jackie Brown | Steve Foucault | Dave Goltz | | 18 | 11 | 7 |
| 1975-04-11 | @ KCA | 4 | L 3-8 | 2-2 | 4 | 20,397 | Vic Albury | Al Fitzmorris | Al Fitzmorris | Bill Butler | | 21 | 19 | 2 |
| 1975-04-12 | @ KCA | 5 | L 1-2 | 2-3 | 4 | 8,369 | Bert Blyleven | Nelson Briles | Doug Bird | Bill Campbell | | 22 | 21 | 1 |
| 1975-04-13 | @ KCA | 6 | L 3-5 | 2-4 | 5 | 7,771 | Joe Decker | Steve Busby | Steve Busby | Joe Decker | Doug Bird | 25 | 26 | -1 |
| 1975-04-15 | vs CAL | 7 | L 3-7 | 2-5 | 6 | 11,909 | Dave Goltz | Nolan Ryan | Nolan Ryan | Dave Goltz | | 28 | 33 | -5 |
| 1975-04-16 | vs CAL | 8 | W 10-4 | 3-5 | 5 | 2,262 | Bert Blyleven | Andy Hassler | Bert Blyleven | Andy Hassler | | 38 | 37 | 1 |
| 1975-04-18 | @ OAK | 9 | W 5-4 | 4-5 | 4 | 5,714 | Vic Albury | Ken Holtzman | Vic Albury | Ken Holtzman | Tom Burgmeier | 43 | 41 | 2 |
| 1975-04-19 | @ OAK | 10 | L 1-4 | 4-6 | 4 | 4,970 | Ray Corbin | Vida Blue | Vida Blue | Ray Corbin | Rollie Fingers | 44 | 45 | -1 |
| 1975-04-20 | @ OAK | 11 | L 1-4 | 4-8 | 5 | 0 | Bert Blyleven | Glenn Abbott | Glenn Abbott | Bert Blyleven | | 45 | 49 | -4 |
| 1975-04-20 | @ OAK | 12 | L 1-5 | 4-8 | 5 | 19,737 | Jim Hughes | Mike Norris | Dave Hamilton | Jim Hughes | Jim Todd | 46 | 54 | -8 |
| 1975-04-21 | @ CAL | 13 | W 8-6 | 5-8 | 4 | 16,291 | Bill Butler | Andy Hassler | Tom Burgmeier | Orlando Pena | | 54 | 60 | -6 |
| 1975-04-22 | @ CAL | 14 | W 7-1 | 6-8 | 4 | 5,540 | Vic Albury | Chuck Dobson | Vic Albury | Chuck Dobson | | 61 | 61 | 0 |
| 1975-04-24 | vs CHA | 15 | L 3-4 | 6-9 | 4 | 2,516 | Bert Blyleven | Wilbur Wood | Wilbur Wood | Tom Burgmeier | Terry Forster | 64 | 65 | -1 |
| 1975-04-26 | vs TEX | 16 | L 2-7 | 6-10 | 6 | 4,698 | Vic Albury | Bill Hands | Bill Hands | Vic Albury | Steve Foucault | 66 | 72 | -6 |
| 1975-05-02 | vs KCA | 17 | W 4-1 | 7-10 | 5 | 2,946 | Dave Goltz | Steve Busby | Dave Goltz | Steve Busby | Tom Burgmeier | 70 | 73 | -3 |
| 1975-05-03 | vs KCA | 18 | W 14-5 | 8-10 | 5 | 18,931 | Bert Blyleven | Paul Splittorff | Bert Blyleven | Paul Splittorff | | 84 | 78 | 6 |
| 1975-05-04 | vs KCA | 19 | W 6-3 | 9-10 | 5 | 14,805 | Vic Albury | Al Fitzmorris | Jim Hughes | Al Fitzmorris | | 90 | 81 | 9 |
| 1975-05-06 | @ CHA | 20 | W 4-1 | 10-10 | 4 | 3,458 | Dave Goltz | Wilbur Wood | Dave Goltz | Wilbur Wood | Bill Campbell | 94 | 82 | 12 |
| 1975-05-07 | @ CHA | 21 | L 2-3 | 10-11 | 5 | 3,255 | Bert Blyleven | Claude Osteen | Terry Forster | Bill Campbell | | 96 | 85 | 11 |
| 1975-05-09 | @ BAL | 22 | W 5-2 | 11-11 | 4 | 7,595 | Jim Hughes | Ross Grimsley | Jim Hughes | Ross Grimsley | | 101 | 87 | 14 |
| 1975-05-10 | @ BAL | 23 | L 6-8 | 11-12 | 5 | 4,757 | Ray Corbin | Mike Torrez | Mike Torrez | Ray Corbin | | 107 | 95 | 12 |
| 1975-05-11 | @ BAL | 24 | W 6-4 | 12-13 | 5 | 0 | Bert Blyleven | Mike Cuellar | Bert Blyleven | Mike Cuellar | | 113 | 99 | 14 |
| 1975-05-11 | @ BAL | 25 | L 3-9 | 12-13 | 5 | 12,536 | Mike Pazik | Jim Palmer | Jim Palmer | Mike Pazik | | 116 | 108 | 8 |
| 1975-05-13 | vs CLE | 26 | L 2-3 | 12-14 | 5 | 4,097 | Vic Albury | Fritz Peterson | Fritz Peterson | Vic Albury | Dennis Eckersley | 118 | 111 | 7 |
| 1975-05-14 | vs CLE | 27 | W 3-0 | 13-14 | 5 | 3,176 | Jim Hughes | Gaylord Perry | Jim Hughes | Gaylord Perry | | 121 | 111 | 10 |
| 1975-05-15 | vs CLE | 28 | W 7-6 | 14-14 | 4 | 5,531 | Bert Blyleven | Don Hood | Tom Burgmeier | Jim Perry | | 128 | 117 | 11 |
| 1975-05-16 | vs MIL | 29 | L 1-3 | 14-15 | 5 | 10,026 | Dave Goltz | Bill Champion | Bill Champion | Dave Goltz | Bill Castro | 129 | 120 | 9 |
| 1975-05-17 | vs MIL | 30 | W 8-7 | 15-15 | 4 | 12,300 | Vic Albury | Jim Colborn | Ray Corbin | Tom Murphy | Bill Campbell | 137 | 127 | 10 |
| 1975-05-18 | vs MIL | 31 | W 6-0 | 16-15 | 4 | 12,608 | Jim Hughes | Ed Sprague | Jim Hughes | Ed Sprague | | 143 | 127 | 16 |
| 1975-05-19 | vs DET | 32 | L 3-6 | 16-16 | 5 | 3,399 | Mike Pazik | Joe Coleman | Joe Coleman | Mike Pazik | John Hiller | 146 | 133 | 13 |
| 1975-05-20 | vs DET | 33 | L 3-5 | 16-17 | 5 | 4,144 | Dave Goltz | Mickey Lolich | Mickey Lolich | Dave Goltz | | 149 | 138 | 11 |
| 1975-05-21 | vs DET | 34 | W 6-5 | 17-17 | 5 | 4,999 | Vic Albury | Vern Ruhle | Ray Corbin | John Hiller | | 155 | 143 | 12 |
| 1975-05-23 | @ MIL | 35 | W 2-1 | 18-17 | 4 | 13,841 | Bert Blyleven | Ed Sprague | Bert Blyleven | Ed Sprague | | 157 | 144 | 13 |
| 1975-05-24 | @ MIL | 36 | W 3-2 | 19-17 | 4 | 22,880 | Jim Hughes | Pete Broberg | Jim Hughes | Pete Broberg | | 160 | 146 | 14 |
| 1975-05-25 | @ MIL | 37 | W 7-2 | 20-17 | 3 | 46,782 | Dave Goltz | Bill Champion | Dave Goltz | Bill Champion | | 167 | 148 | 19 |
| 1975-05-26 | @ DET | 38 | L 2-6 | 20-18 | 3 | 15,361 | Bill Campbell | Vern Ruhle | Vern Ruhle | Bill Campbell | | 169 | 154 | 15 |
| 1975-05-27 | @ DET | 39 | W 6-5 | 21-18 | 3 | 8,764 | Bert Blyleven | Lerrin LaGrow | Vic Albury | John Hiller | | 175 | 159 | 16 |
| 1975-05-28 | @ DET | 40 | W 5-2 | 22-18 | 3 | 9,675 | Jim Hughes | Joe Coleman | Jim Hughes | Joe Coleman | | 180 | 161 | 19 |
| 1975-05-30 | vs BOS | 41 | W 4-3 | 23-18 | 3 | 11,666 | Dave Goltz | Dick Pole | Dave Goltz | Diego Segui | Tom Burgmeier | 184 | 164 | 20 |
| 1975-05-31 | vs BOS | 42 | L 8-12 | 23-19 | 3 | 10,873 | Bert Blyleven | Rick Wise | Roger Moret | Tom Burgmeier | | 192 | 176 | 16 |
| 1975-06-01 | vs BOS | 43 | L 9-11 | 23-20 | 3 | 25,493 | Jim Hughes | Luis Tiant | Luis Tiant | Jim Hughes | Dick Drago | 201 | 187 | 14 |
| 1975-06-03 | vs NYA | 44 | L 4-5 | 23-21 | 3 | 10,184 | Dave Goltz | Pat Dobson | Pat Dobson | Dave Goltz | Sparky Lyle | 205 | 192 | 13 |
| 1975-06-04 | vs NYA | 45 | L 3-6 | 23-22 | 3 | 9,161 | Bert Blyleven | Doc Medich | Doc Medich | Bert Blyleven | Dick Tidrow | 208 | 198 | 10 |
| 1975-06-05 | vs NYA | 46 | L 4-7 | 23-23 | 3 | 11,721 | Jim Hughes | Catfish Hunter | Catfish Hunter | Jim Hughes | | 212 | 205 | 7 |
| 1975-06-06 | @ BOS | 47 | L 10-13 | 23-24 | 4 | 18,120 | Joe Decker | Luis Tiant | Luis Tiant | Mike Pazik | Dick Drago | 222 | 218 | 4 |
| 1975-06-07 | @ BOS | 48 | L 1-3 | 23-25 | 5 | 18,649 | Ray Corbin | Bill Lee | Bill Lee | Ray Corbin | | 223 | 221 | 2 |
| 1975-06-08 | @ BOS | 49 | W 7-5 | 24-25 | 5 | 18,301 | Dave Goltz | Dick Pole | Dave Goltz | Dick Pole | Tom Burgmeier | 230 | 226 | 4 |
| 1975-06-09 | @ CLE | 50 | W 11-10 | 25-25 | 3 | 6,912 | Jim Hughes | Roric Harrison | Vic Albury | Tom Buskey | | 241 | 236 | 5 |
| 1975-06-10 | @ CLE | 51 | W 5-3 | 26-25 | 3 | 6,340 | Joe Decker | Dennis Eckersley | Tom Burgmeier | Dave LaRoche | | 246 | 239 | 7 |
| 1975-06-11 | @ NYA | 52 | L 1-5 | 26-26 | 3 | 13,659 | Mike Pazik | Rudy May | Rudy May | Mike Pazik | | 247 | 244 | 3 |
| 1975-06-13 | vs BAL | 53 | W 7-3 | 27-26 | 3 | 9,791 | Dave Goltz | Mike Cuellar | Dave Goltz | Mike Cuellar | | 254 | 247 | 7 |
| 1975-06-14 | vs BAL | 54 | L 0-7 | 27-27 | 4 | 9,718 | Jim Hughes | Ross Grimsley | Ross Grimsley | Jim Hughes | | 254 | 254 | 0 |
| 1975-06-15 | vs BAL | 55 | W 5-4 | 28-27 | 3 | 13,400 | Ray Corbin | Mike Torrez | Ray Corbin | Mike Torrez | | 259 | 258 | 1 |
| 1975-06-16 | vs OAK | 56 | W 7-6 | 29-27 | 3 | 11,058 | Bill Campbell | Dick Bosman | Tom Burgmeier | Rollie Fingers | | 266 | 264 | 2 |
| 1975-06-17 | vs OAK | 57 | L 2-4 | 29-29 | 3 | 0 | Dave Goltz | Vida Blue | Vida Blue | Dave Goltz | | 268 | 268 | 0 |
| 1975-06-17 | vs OAK | 58 | L 7-8 | 29-29 | 3 | 16,752 | Bill Butler | Ken Holtzman | Ken Holtzman | Bill Butler | Jim Todd | 275 | 276 | -1 |
| 1975-06-18 | vs OAK | 59 | L 6-7 | 29-30 | 4 | 14,706 | Vic Albury | Jim Perry | Jim Todd | Vic Albury | Rollie Fingers | 281 | 283 | -2 |
| 1975-06-19 | vs OAK | 60 | L 2-5 | 29-31 | 4 | 12,206 | Jim Hughes | Sonny Siebert | Glenn Abbott | Jim Hughes | Paul Lindblad | 283 | 288 | -5 |
| 1975-06-20 | @ CHA | 61 | W 5-3 | 30-31 | 4 | 9,208 | Ray Corbin | Dave Hamilton | Ray Corbin | Dave Hamilton | | 288 | 291 | -3 |
| 1975-06-21 | @ CHA | 62 | W 8-3 | 31-31 | 3 | 15,079 | Bill Campbell | Jim Kaat | Bill Campbell | Jim Kaat | | 296 | 294 | 2 |
| 1975-06-22 | @ CHA | 63 | L 5-6 | 31-33 | 5 | 0 | Dave Goltz | Wilbur Wood | Ozzie Osborn | Tom Burgmeier | | 301 | 300 | 1 |
| 1975-06-22 | @ CHA | 64 | L 2-9 | 31-33 | 5 | 23,299 | Vic Albury | Jesse Jefferson | Jesse Jefferson | Vic Albury | Cecil Upshaw | 303 | 309 | -6 |
| 1975-06-23 | @ OAK | 65 | L 2-5 | 31-34 | 5 | 29,410 | Jim Hughes | Jim Perry | Paul Lindblad | Jim Hughes | | 305 | 314 | -9 |
| 1975-06-24 | @ OAK | 66 | L 4-6 | 31-35 | 5 | 4,826 | Joe Decker | Stan Bahnsen | Jim Todd | Joe Decker | | 309 | 320 | -11 |
| 1975-06-25 | @ OAK | 67 | L 1-7 | 31-36 | 5 | 4,723 | Ray Corbin | Ken Holtzman | Ken Holtzman | Ray Corbin | | 310 | 327 | -17 |
| 1975-06-27 | @ TEX | 68 | L 0-2 | 32-37 | 4 | 0 | Bert Blyleven | Steve Hargan | Steve Hargan | Bert Blyleven | | 310 | 329 | -19 |
| 1975-06-27 | @ TEX | 69 | W 8-5 | 32-37 | 4 | 20,601 | Dave Goltz | Bill Hands | Vic Albury | Jim Umbarger | | 318 | 334 | -16 |
| 1975-06-28 | @ TEX | 70 | W 5-3 | 33-37 | 4 | 18,191 | Jim Hughes | Gaylord Perry | Jim Hughes | Gaylord Perry | | 323 | 337 | -14 |
| 1975-06-29 | @ TEX | 71 | L 7-9 | 33-38 | 5 | 9,052 | Bill Campbell | Mike Bacsik | Mike Bacsik | Bill Campbell | Mike Kekich | 330 | 346 | -16 |
| 1975-06-30 | vs CAL | 72 | L 3-10 | 33-39 | 5 | 7,033 | Ray Corbin | Frank Tanana | Frank Tanana | Ray Corbin | | 333 | 356 | -23 |
| 1975-07-01 | vs CAL | 73 | L 3-4 | 34-40 | 5 | 0 | Dave Goltz | Ed Figueroa | Dick Lange | Tom Burgmeier | | 336 | 360 | -24 |
| 1975-07-01 | vs CAL | 74 | W 12-3 | 34-40 | 5 | 7,109 | Mark Wiley | Andy Hassler | Mark Wiley | Andy Hassler | | 348 | 363 | -15 |
| 1975-07-02 | vs CAL | 75 | W 9-4 | 35-40 | 5 | 6,435 | Bert Blyleven | Charlie Hudson | Bert Blyleven | Charlie Hudson | Vic Albury | 357 | 367 | -10 |
| 1975-07-03 | vs CAL | 76 | L 6-7 | 35-41 | 5 | 6,071 | Jim Hughes | Nolan Ryan | Mickey Scott | Bill Butler | Don Kirkwood | 363 | 374 | -11 |
| 1975-07-04 | vs TEX | 77 | W 8-0 | 36-42 | 5 | 0 | Bill Campbell | Mike Bacsik | Bill Campbell | Mike Bacsik | | 371 | 374 | -3 |
| 1975-07-04 | vs TEX | 78 | L 2-4 | 36-42 | 5 | 25,714 | Ray Corbin | Steve Hargan | Steve Hargan | Ray Corbin | | 373 | 378 | -5 |
| 1975-07-05 | vs TEX | 79 | W 5-4 | 37-42 | 5 | 9,399 | Dave Goltz | Fergie Jenkins | Dave Goltz | Fergie Jenkins | | 378 | 382 | -4 |
| 1975-07-06 | vs TEX | 80 | L 2-4 | 37-44 | 6 | 0 | Bert Blyleven | Clyde Wright | Clyde Wright | Bert Blyleven | Jim Umbarger | 380 | 386 | -6 |
| 1975-07-06 | vs TEX | 81 | L 0-7 | 37-44 | 6 | 14,211 | Mark Wiley | Gaylord Perry | Gaylord Perry | Mark Wiley | | 380 | 393 | -13 |
| 1975-07-07 | @ BOS | 82 | L 3-6 | 37-45 | 6 | 21,885 | Jim Hughes | Rick Wise | Rick Wise | Jim Hughes | Jim Willoughby | 383 | 399 | -16 |
| 1975-07-08 | @ BOS | 83 | L 5-6 | 37-46 | 6 | 17,519 | Bill Campbell | Luis Tiant | Reggie Cleveland | Tom Johnson | | 388 | 405 | -17 |
| 1975-07-09 | @ BOS | 84 | L 8-9 | 37-47 | 6 | 21,103 | Dave Goltz | Roger Moret | Diego Segui | Tom Burgmeier | | 396 | 414 | -18 |
| 1975-07-10 | @ NYA | 85 | W 6-3 | 38-47 | 6 | 12,556 | Ray Corbin | Pat Dobson | Ray Corbin | Pat Dobson | Tom Johnson | 402 | 417 | -15 |
| 1975-07-11 | @ NYA | 86 | W 11-1 | 39-48 | 6 | 0 | Bert Blyleven | Doc Medich | Bert Blyleven | Doc Medich | | 413 | 418 | -5 |
| 1975-07-11 | @ NYA | 87 | L 3-4 | 39-48 | 6 | 21,355 | Mark Wiley | Larry Gura | Larry Gura | Mark Wiley | | 416 | 422 | -6 |
| 1975-07-12 | @ NYA | 88 | L 7-8 | 39-49 | 6 | 13,573 | Jim Hughes | Catfish Hunter | Tippy Martinez | Tom Burgmeier | | 423 | 430 | -7 |
| 1975-07-17 | @ BAL | 89 | L 3-6 | 39-50 | 6 | 10,809 | Bert Blyleven | Mike Torrez | Grant Jackson | Bill Campbell | | 426 | 436 | -10 |
| 1975-07-18 | @ BAL | 90 | L 6-9 | 39-51 | 6 | 13,698 | Dave Goltz | Mike Cuellar | Mike Cuellar | Dave Goltz | Dyar Miller | 432 | 445 | -13 |
| 1975-07-19 | vs NYA | 91 | W 2-1 | 40-51 | 6 | 37,602 | Jim Hughes | Doc Medich | Jim Hughes | Doc Medich | Tom Burgmeier | 434 | 446 | -12 |
| 1975-07-20 | vs NYA | 92 | L 2-14 | 40-53 | 6 | 0 | Ray Corbin | Rudy May | Rudy May | Ray Corbin | | 436 | 460 | -24 |
| 1975-07-20 | vs NYA | 93 | L 4-5 | 40-53 | 6 | 23,782 | Vic Albury | Larry Gura | Dick Tidrow | Bill Campbell | | 440 | 465 | -25 |
| 1975-07-21 | vs NYA | 94 | W 3-0 | 41-53 | 6 | 12,475 | Bert Blyleven | Pat Dobson | Bert Blyleven | Pat Dobson | | 443 | 465 | -22 |
| 1975-07-22 | vs BOS | 95 | L 4-5 | 41-54 | 6 | 9,531 | Dave Goltz | Bill Lee | Bill Lee | Dave Goltz | | 447 | 470 | -23 |
| 1975-07-23 | vs BOS | 96 | L 2-4 | 41-55 | 6 | 9,452 | Jim Hughes | Roger Moret | Roger Moret | Jim Hughes | Jim Willoughby | 449 | 474 | -25 |
| 1975-07-24 | vs BOS | 97 | L 2-6 | 41-56 | 6 | 14,880 | Joe Decker | Rick Wise | Rick Wise | Joe Decker | | 451 | 480 | -29 |
| 1975-07-25 | @ CAL | 98 | W 12-1 | 42-56 | 6 | 12,432 | Bert Blyleven | Bill Singer | Bert Blyleven | Bill Singer | | 463 | 481 | -18 |
| 1975-07-26 | @ CAL | 99 | W 9-4 | 43-57 | 6 | 0 | Dave Goltz | Ed Figueroa | Dave Goltz | Ed Figueroa | | 472 | 485 | -13 |
| 1975-07-26 | @ CAL | 100 | L 0-5 | 43-57 | 6 | 16,801 | Vic Albury | Nolan Ryan | Nolan Ryan | Vic Albury | Jim Brewer | 472 | 490 | -18 |
| 1975-07-27 | @ CAL | 101 | L 1-6 | 43-58 | 6 | 7,633 | Jim Hughes | Dick Lange | Dick Lange | Jim Hughes | | 473 | 496 | -23 |
| 1975-07-28 | vs KCA | 102 | W 9-8 | 44-58 | 6 | 6,829 | Ray Corbin | Marty Pattin | Tom Burgmeier | Doug Bird | | 482 | 504 | -22 |
| 1975-07-29 | vs KCA | 103 | L 2-5 | 44-59 | 6 | 8,558 | Bert Blyleven | Paul Splittorff | Paul Splittorff | Bert Blyleven | Steve Mingori | 484 | 509 | -25 |
| 1975-07-30 | vs KCA | 104 | L 4-6 | 44-60 | 6 | 6,906 | Vic Albury | Dennis Leonard | Dennis Leonard | Vic Albury | Doug Bird | 488 | 515 | -27 |
| 1975-07-31 | vs KCA | 105 | W 7-2 | 45-60 | 6 | 11,410 | Jim Hughes | Al Fitzmorris | Jim Hughes | Al Fitzmorris | | 495 | 517 | -22 |
| 1975-08-01 | vs CHA | 106 | L 1-5 | 45-61 | 6 | 12,239 | Dave Goltz | Wilbur Wood | Wilbur Wood | Dave Goltz | | 496 | 522 | -26 |
| 1975-08-02 | vs CHA | 107 | W 4-1 | 47-61 | 5 | 0 | Bert Blyleven | Claude Osteen | Bert Blyleven | Claude Osteen | | 500 | 523 | -23 |
| 1975-08-02 | vs CHA | 108 | W 8-3 | 47-61 | 5 | 17,194 | Bill Butler | Jesse Jefferson | Bill Butler | Jesse Jefferson | | 508 | 526 | -18 |
| 1975-08-03 | vs CHA | 109 | W 7-4 | 49-61 | 5 | 0 | Vic Albury | Jim Kaat | Vic Albury | Jim Kaat | Mark Wiley | 515 | 530 | -15 |
| 1975-08-03 | vs CHA | 110 | W 12-9 | 49-61 | 5 | 14,782 | Bill Campbell | Pete Vuckovich | Bill Campbell | Pete Vuckovich | Mark Wiley | 527 | 539 | -12 |
| 1975-08-04 | @ KCA | 111 | L 5-6 | 49-62 | 5 | 12,195 | Jim Hughes | Dennis Leonard | Doug Bird | Mark Wiley | | 532 | 545 | -13 |
| 1975-08-05 | @ KCA | 112 | L 1-6 | 49-63 | 5 | 14,275 | Dave Goltz | Al Fitzmorris | Al Fitzmorris | Dave Goltz | | 533 | 551 | -18 |
| 1975-08-06 | @ KCA | 113 | L 3-4 | 49-64 | 5 | 17,211 | Bert Blyleven | Steve Busby | Steve Busby | Bert Blyleven | | 536 | 555 | -19 |
| 1975-08-07 | @ KCA | 114 | L 2-10 | 49-65 | 5 | 15,596 | Vic Albury | Paul Splittorff | Paul Splittorff | Vic Albury | | 538 | 565 | -27 |
| 1975-08-08 | @ DET | 115 | W 3-1 | 50-65 | 5 | 18,259 | Jim Hughes | Joe Coleman | Jim Hughes | Joe Coleman | | 541 | 566 | -25 |
| 1975-08-09 | @ DET | 116 | W 1-0 | 51-65 | 5 | 18,028 | Dave Goltz | Mickey Lolich | Dave Goltz | Mickey Lolich | | 542 | 566 | -24 |
| 1975-08-10 | @ DET | 117 | W 4-0 | 52-65 | 5 | 11,851 | Bert Blyleven | Ray Bare | Bert Blyleven | Ray Bare | | 546 | 566 | -20 |
| 1975-08-11 | vs MIL | 118 | W 8-7 | 53-65 | 5 | 11,238 | Bill Butler | Jim Slaton | Tom Johnson | Jim Slaton | | 554 | 573 | -19 |
| 1975-08-12 | vs MIL | 119 | L 4-7 | 53-66 | 5 | 14,023 | Jim Hughes | Bill Travers | Bill Travers | Jim Hughes | Tom Murphy | 558 | 580 | -22 |
| 1975-08-13 | vs MIL | 120 | W 5-2 | 54-66 | 5 | 12,669 | Dave Goltz | Tom Hausman | Dave Goltz | Tom Hausman | | 563 | 582 | -19 |
| 1975-08-15 | vs CLE | 121 | W 8-4 | 55-66 | 5 | 11,277 | Bert Blyleven | Dennis Eckersley | Bert Blyleven | Dennis Eckersley | | 571 | 586 | -15 |
| 1975-08-16 | vs CLE | 122 | W 9-1 | 56-66 | 5 | 11,761 | Jim Hughes | Eric Raich | Jim Hughes | Eric Raich | | 580 | 587 | -7 |
| 1975-08-17 | vs CLE | 123 | L 5-14 | 56-67 | 5 | 7,914 | Bill Butler | Fritz Peterson | Fritz Peterson | Bill Butler | | 585 | 601 | -16 |
| 1975-08-18 | vs BAL | 124 | W 6-1 | 57-67 | 5 | 8,405 | Dave Goltz | Mike Torrez | Dave Goltz | Mike Torrez | | 591 | 602 | -11 |
| 1975-08-19 | vs BAL | 125 | W 5-2 | 58-67 | 5 | 9,928 | Bert Blyleven | Mike Cuellar | Bert Blyleven | Mike Cuellar | | 596 | 604 | -8 |
| 1975-08-20 | vs BAL | 126 | L 2-3 | 58-68 | 5 | 8,153 | Jim Hughes | Ross Grimsley | Ross Grimsley | Jim Hughes | | 598 | 607 | -9 |
| 1975-08-22 | vs DET | 127 | W 8-4 | 59-68 | 5 | 8,101 | Dave Goltz | Vern Ruhle | Dave Goltz | Vern Ruhle | Bill Campbell | 606 | 611 | -5 |
| 1975-08-23 | vs DET | 128 | L 5-6 | 59-69 | 5 | 9,052 | Bert Blyleven | Lerrin LaGrow | Dave Lemanczyk | Tom Burgmeier | | 611 | 617 | -6 |
| 1975-08-24 | vs DET | 129 | W 3-1 | 60-69 | 5 | 7,570 | Jim Hughes | Mickey Lolich | Jim Hughes | Mickey Lolich | | 614 | 618 | -4 |
| 1975-08-25 | @ MIL | 130 | W 6-3 | 61-69 | 5 | 7,779 | Joe Decker | Jim Slaton | Bill Butler | Jim Slaton | | 620 | 621 | -1 |
| 1975-08-26 | @ MIL | 131 | W 2-1 | 62-69 | 5 | 9,941 | Dave Goltz | Pete Broberg | Dave Goltz | Pete Broberg | | 622 | 622 | 0 |
| 1975-08-27 | @ MIL | 132 | W 1-0 | 63-69 | 5 | 6,261 | Bert Blyleven | Bill Travers | Bert Blyleven | Bill Travers | | 623 | 622 | 1 |
| 1975-08-29 | @ CLE | 133 | L 6-9 | 63-70 | 5 | 6,520 | Jim Hughes | Rick Waits | Don Hood | Jim Hughes | Bob Reynolds | 629 | 631 | -2 |
| 1975-09-01 | @ TEX | 134 | W 5-4 | 64-70 | 5 | 5,917 | Bert Blyleven | Fergie Jenkins | Bill Butler | Fergie Jenkins | Tom Johnson | 634 | 635 | -1 |
| 1975-09-02 | @ TEX | 135 | W 5-3 | 65-70 | 5 | 5,002 | Jim Hughes | Steve Hargan | Jim Hughes | Steve Hargan | Tom Burgmeier | 639 | 638 | 1 |
| 1975-09-05 | @ CHA | 136 | L 2-3 | 65-71 | 5 | 4,400 | Dave Goltz | Wilbur Wood | Wilbur Wood | Dave Goltz | Rich Gossage | 641 | 641 | 0 |
| 1975-09-06 | @ CHA | 137 | L 2-5 | 65-72 | 5 | 7,078 | Bert Blyleven | Jim Kaat | Jim Kaat | Bert Blyleven | Rich Gossage | 643 | 646 | -3 |
| 1975-09-07 | @ CHA | 138 | W 9-1 | 66-72 | 5 | 6,008 | Jim Hughes | Claude Osteen | Jim Hughes | Claude Osteen | | 652 | 647 | 5 |
| 1975-09-09 | vs TEX | 139 | L 0-3 | 66-74 | 5 | 0 | Dave Goltz | Jim Umbarger | Jim Umbarger | Dave Goltz | | 652 | 650 | 2 |
| 1975-09-09 | vs TEX | 140 | L 2-4 | 66-74 | 5 | 4,300 | Bill Butler | Stan Perzanowski | Stan Perzanowski | Tom Johnson | Steve Foucault | 654 | 654 | 0 |
| 1975-09-10 | vs TEX | 141 | L 4-9 | 66-75 | 5 | 3,339 | Bert Blyleven | Gaylord Perry | Gaylord Perry | Bert Blyleven | | 658 | 663 | -5 |
| 1975-09-12 | vs OAK | 142 | L 4-11 | 67-76 | 5 | 0 | Jim Hughes | Dick Bosman | Dick Bosman | Jim Hughes | Jim Todd | 662 | 674 | -12 |
| 1975-09-12 | vs OAK | 143 | W 7-6 | 67-76 | 5 | 6,837 | Eddie Bane | Sonny Siebert | Eddie Bane | Paul Lindblad | Tom Burgmeier | 669 | 680 | -11 |
| 1975-09-13 | vs OAK | 144 | L 5-8 | 67-77 | 5 | 9,360 | Dave Goltz | Ken Holtzman | Ken Holtzman | Dave Goltz | Rollie Fingers | 674 | 688 | -14 |
| 1975-09-14 | vs OAK | 145 | W 10-8 | 68-77 | 5 | 22,772 | Bill Butler | Glenn Abbott | Bill Butler | Glenn Abbott | Tom Burgmeier | 684 | 696 | -12 |
| 1975-09-15 | vs CAL | 146 | W 7-6 | 69-77 | 4 | 3,023 | Bert Blyleven | Joe Pactwa | Bill Campbell | Chuck Hockenbery | | 691 | 702 | -11 |
| 1975-09-16 | vs CAL | 147 | W 4-3 | 70-77 | 4 | 2,880 | Jim Hughes | Sid Monge | Jim Hughes | Sid Monge | | 695 | 705 | -10 |
| 1975-09-17 | vs KCA | 148 | W 2-1 | 71-77 | 4 | 3,154 | Dave Goltz | Al Fitzmorris | Dave Goltz | Al Fitzmorris | | 697 | 706 | -9 |
| 1975-09-18 | vs KCA | 149 | L 3-4 | 71-78 | 4 | 3,201 | Eddie Bane | Doug Bird | Ray Sadecki | Eddie Bane | George Throop | 700 | 710 | -10 |
| 1975-09-19 | @ CAL | 150 | L 0-1 | 71-79 | 4 | 8,059 | Bert Blyleven | Joe Pactwa | Joe Pactwa | Bert Blyleven | Jim Brewer | 700 | 711 | -11 |
| 1975-09-20 | @ CAL | 151 | W 3-2 | 72-79 | 4 | 9,767 | Jim Hughes | Sid Monge | Jim Hughes | Sid Monge | Tom Burgmeier | 703 | 713 | -10 |
| 1975-09-21 | @ CAL | 152 | L 2-5 | 72-80 | 4 | 8,401 | Dave Goltz | Ed Figueroa | Ed Figueroa | Dave Goltz | Jim Brewer | 705 | 718 | -13 |
| 1975-09-22 | @ OAK | 153 | W 2-1 | 73-80 | 4 | 20,497 | Eddie Bane | Ken Holtzman | Eddie Bane | Ken Holtzman | Tom Burgmeier | 707 | 719 | -12 |
| 1975-09-23 | @ OAK | 154 | W 4-3 | 74-80 | 4 | 3,979 | Bert Blyleven | Stan Bahnsen | Bert Blyleven | Stan Bahnsen | | 711 | 722 | -11 |
| 1975-09-24 | @ KCA | 155 | L 2-4 | 74-81 | 4 | 6,653 | Jim Hughes | Mark Littell | Marty Pattin | Jim Hughes | | 713 | 726 | -13 |
| 1975-09-25 | @ KCA | 156 | W 5-2 | 75-81 | 4 | 7,309 | Bill Butler | Paul Splittorff | Bill Butler | Paul Splittorff | Tom Johnson | 718 | 728 | -10 |
| 1975-09-26 | vs CHA | 157 | W 2-1 | 76-81 | 3 | 2,769 | Eddie Bane | Jim Kaat | Eddie Bane | Jim Kaat | Bill Campbell | 720 | 729 | -9 |
| 1975-09-27 | vs CHA | 158 | L 0-1 | 76-82 | 4 | 4,463 | Bert Blyleven | Claude Osteen | Rich Gossage | Bert Blyleven | | 720 | 730 | -10 |
| 1975-09-28 | vs CHA | 159 | L 4-6 | 76-83 | 4 | 4,279 | Jim Hughes | Jesse Jefferson | Dave Hamilton | Tom Burgmeier | | 724 | 736 | -12 |