| 1975-04-07 | @ CIN | 1 | L 1-2 | 0-1 | 4 | 52,526 | Don Sutton | Don Gullett | Pat Darcy | Charlie Hough | | 1 | 2 | -1 |
| 1975-04-09 | @ CIN | 2 | L 3-4 | 0-2 | 4 | 15,554 | Andy Messersmith | Jack Billingham | Pedro Borbon | Mike Marshall | | 4 | 6 | -2 |
| 1975-04-10 | @ CIN | 3 | L 6-7 | 0-3 | 5 | 20,550 | Doug Rau | Clay Kirby | Clay Carroll | Charlie Hough | | 10 | 13 | -3 |
| 1975-04-11 | @ HOU | 4 | W 7-0 | 1-3 | 6 | 17,851 | Don Sutton | Tom Griffin | Don Sutton | Tom Griffin | | 17 | 13 | 4 |
| 1975-04-12 | @ HOU | 5 | L 5-7 | 1-4 | 6 | 25,024 | Juan Marichal | Larry Dierker | Larry Dierker | Juan Marichal | Wayne Granger | 22 | 20 | 2 |
| 1975-04-13 | @ HOU | 6 | W 7-4 | 2-4 | 6 | 17,310 | Andy Messersmith | Doug Konieczny | Andy Messersmith | Doug Konieczny | | 29 | 24 | 5 |
| 1975-04-14 | vs CIN | 7 | W 5-2 | 3-4 | 6 | 45,502 | Doug Rau | Jack Billingham | Doug Rau | Jack Billingham | Mike Marshall | 34 | 26 | 8 |
| 1975-04-15 | vs CIN | 8 | W 3-1 | 4-4 | 4 | 31,663 | Don Sutton | Clay Kirby | Don Sutton | Clay Kirby | | 37 | 27 | 10 |
| 1975-04-16 | vs CIN | 9 | W 7-6 | 5-4 | 3 | 36,578 | Juan Marichal | Fred Norman | Mike Marshall | Clay Carroll | | 44 | 33 | 11 |
| 1975-04-17 | vs CIN | 10 | W 5-4 | 6-4 | 2 | 27,835 | Andy Messersmith | Gary Nolan | Mike Marshall | Clay Carroll | | 49 | 37 | 12 |
| 1975-04-18 | vs SFN | 11 | L 1-3 | 6-5 | 4 | 53,060 | Doug Rau | John Montefusco | John Montefusco | Doug Rau | | 50 | 40 | 10 |
| 1975-04-19 | vs SFN | 12 | W 3-2 | 7-5 | 2 | 47,053 | Don Sutton | Pete Falcone | Don Sutton | Pete Falcone | Charlie Hough | 53 | 42 | 11 |
| 1975-04-20 | vs SFN | 13 | L 3-6 | 7-6 | 4 | 47,595 | Rick Rhoden | Jim Barr | Randy Moffitt | Geoff Zahn | | 56 | 48 | 8 |
| 1975-04-21 | @ ATL | 14 | W 2-1 | 8-6 | 3 | 9,256 | Andy Messersmith | Buzz Capra | Andy Messersmith | Buzz Capra | | 58 | 49 | 9 |
| 1975-04-22 | @ ATL | 15 | L 2-3 | 8-7 | 4 | 5,049 | Doug Rau | Carl Morton | Carl Morton | Charlie Hough | Roric Harrison | 60 | 52 | 8 |
| 1975-04-23 | @ SDN | 16 | L 1-7 | 8-8 | 4 | 43,478 | Don Sutton | Joe McIntosh | Joe McIntosh | Don Sutton | | 61 | 59 | 2 |
| 1975-04-24 | @ SDN | 17 | W 11-6 | 9-8 | 4 | 21,789 | Rick Rhoden | Dave Freisleben | Rick Rhoden | Dave Freisleben | Al Downing | 72 | 65 | 7 |
| 1975-04-25 | @ SFN | 18 | W 6-5 | 10-8 | 2 | 14,153 | Andy Messersmith | Mike Caldwell | Andy Messersmith | Mike Caldwell | Jim Brewer | 78 | 70 | 8 |
| 1975-04-26 | @ SFN | 19 | W 13-3 | 11-8 | 2 | 11,304 | Doug Rau | John D'Acquisto | Doug Rau | John D'Acquisto | | 91 | 73 | 18 |
| 1975-04-27 | @ SFN | 20 | W 7-3 | 12-8 | 1 | 35,517 | Don Sutton | John Montefusco | Don Sutton | John Montefusco | | 98 | 76 | 22 |
| 1975-04-28 | vs ATL | 21 | W 4-3 | 13-8 | 1 | 32,097 | Rick Rhoden | Phil Niekro | Jim Brewer | Tom House | | 102 | 79 | 23 |
| 1975-04-29 | vs ATL | 22 | W 8-0 | 14-8 | 1 | 31,638 | Andy Messersmith | Buzz Capra | Andy Messersmith | Buzz Capra | | 110 | 79 | 31 |
| 1975-04-30 | vs ATL | 23 | W 5-2 | 15-8 | 1 | 29,640 | Doug Rau | Carl Morton | Doug Rau | Carl Morton | | 115 | 81 | 34 |
| 1975-05-02 | vs SDN | 24 | W 3-0 | 16-8 | 1 | 53,701 | Don Sutton | Dan Spillner | Don Sutton | Dan Spillner | | 118 | 81 | 37 |
| 1975-05-03 | vs SDN | 25 | L 1-3 | 16-9 | 1 | 48,830 | Andy Messersmith | Joe McIntosh | Alan Foster | Jim Brewer | | 119 | 84 | 35 |
| 1975-05-04 | vs SDN | 26 | L 7-10 | 16-10 | 1 | 42,100 | Rick Rhoden | Dave Freisleben | Randy Jones | Burt Hooton | | 126 | 94 | 32 |
| 1975-05-05 | vs HOU | 27 | W 2-0 | 17-10 | 1 | 22,236 | Doug Rau | Larry Dierker | Doug Rau | Larry Dierker | | 128 | 94 | 34 |
| 1975-05-06 | vs HOU | 28 | W 3-1 | 18-10 | 1 | 23,788 | Don Sutton | Doug Konieczny | Don Sutton | Doug Konieczny | | 131 | 95 | 36 |
| 1975-05-07 | vs HOU | 29 | W 5-1 | 19-10 | 1 | 31,222 | Andy Messersmith | Tom Griffin | Andy Messersmith | Tom Griffin | | 136 | 96 | 40 |
| 1975-05-09 | @ PIT | 30 | L 3-11 | 19-11 | 1 | 16,378 | Burt Hooton | Dock Ellis | Dock Ellis | Mike Marshall | Dave Giusti | 139 | 107 | 32 |
| 1975-05-10 | @ PIT | 31 | W 6-2 | 20-11 | 1 | 24,870 | Doug Rau | Jim Rooker | Doug Rau | Jim Rooker | | 145 | 109 | 36 |
| 1975-05-11 | @ PIT | 32 | W 7-0 | 21-11 | 1 | 15,175 | Don Sutton | Ken Brett | Don Sutton | Ken Brett | | 152 | 109 | 43 |
| 1975-05-12 | @ SLN | 33 | W 6-4 | 22-11 | 1 | 13,342 | Andy Messersmith | John Denny | Jim Brewer | Mike Garman | | 158 | 113 | 45 |
| 1975-05-13 | @ SLN | 34 | W 5-0 | 23-11 | 1 | 18,519 | Burt Hooton | Lynn McGlothen | Burt Hooton | Lynn McGlothen | | 163 | 113 | 50 |
| 1975-05-14 | @ SLN | 35 | L 4-7 | 23-12 | 1 | 14,388 | Doug Rau | John Curtis | John Curtis | Doug Rau | Al Hrabosky | 167 | 120 | 47 |
| 1975-05-16 | vs PIT | 36 | L 2-3 | 23-13 | 1 | 44,111 | Don Sutton | Bruce Kison | Dave Giusti | Don Sutton | | 169 | 123 | 46 |
| 1975-05-17 | vs PIT | 37 | W 4-3 | 24-13 | 1 | 46,790 | Andy Messersmith | Jim Rooker | Andy Messersmith | Ramon Hernandez | | 173 | 126 | 47 |
| 1975-05-18 | vs PIT | 38 | L 2-7 | 24-14 | 1 | 42,013 | Burt Hooton | Ken Brett | Ken Brett | Burt Hooton | | 175 | 133 | 42 |
| 1975-05-19 | vs CHN | 39 | W 3-2 | 25-14 | 1 | 21,790 | Doug Rau | Rick Reuschel | Jim Brewer | Darold Knowles | | 178 | 135 | 43 |
| 1975-05-20 | vs CHN | 40 | L 1-2 | 25-15 | 1 | 24,526 | Don Sutton | Bill Bonham | Bill Bonham | Don Sutton | | 179 | 137 | 42 |
| 1975-05-21 | vs CHN | 41 | W 10-0 | 26-15 | 1 | 32,315 | Andy Messersmith | Geoff Zahn | Andy Messersmith | Geoff Zahn | | 189 | 137 | 52 |
| 1975-05-22 | vs CHN | 42 | W 8-3 | 27-15 | 1 | 23,579 | Burt Hooton | Ray Burris | Burt Hooton | Ray Burris | | 197 | 140 | 57 |
| 1975-05-23 | vs SLN | 43 | L 3-4 | 27-16 | 1 | 53,033 | Al Downing | Bob Forsch | Al Hrabosky | Charlie Hough | Mike Garman | 200 | 144 | 56 |
| 1975-05-24 | vs SLN | 44 | L 2-6 | 27-17 | 1 | 45,196 | Doug Rau | Lynn McGlothen | Lynn McGlothen | Doug Rau | Al Hrabosky | 202 | 150 | 52 |
| 1975-05-25 | vs SLN | 45 | W 7-3 | 28-17 | 1 | 43,958 | Don Sutton | John Curtis | Don Sutton | John Curtis | | 209 | 153 | 56 |
| 1975-05-26 | @ NYN | 46 | L 3-6 | 28-18 | 1 | 34,502 | Andy Messersmith | Tom Seaver | Tom Seaver | Andy Messersmith | | 212 | 159 | 53 |
| 1975-05-27 | @ NYN | 47 | W 10-4 | 29-18 | 1 | 20,538 | Burt Hooton | Harry Parker | Burt Hooton | Harry Parker | | 222 | 163 | 59 |
| 1975-05-28 | @ NYN | 48 | L 3-4 | 29-19 | 1 | 24,464 | Doug Rau | Jon Matlack | Jon Matlack | Doug Rau | Bob Apodaca | 225 | 167 | 58 |
| 1975-05-30 | @ CHN | 49 | W 3-1 | 30-19 | 1 | 21,197 | Don Sutton | Ray Burris | Don Sutton | Ray Burris | Andy Messersmith | 228 | 168 | 60 |
| 1975-05-31 | @ CHN | 50 | L 1-2 | 30-20 | 1 | 21,344 | Andy Messersmith | Rick Reuschel | Rick Reuschel | Andy Messersmith | | 229 | 170 | 59 |
| 1975-06-01 | @ CHN | 51 | L 2-7 | 30-21 | 1 | 31,325 | Burt Hooton | Bill Bonham | Bill Bonham | Burt Hooton | Oscar Zamora | 231 | 177 | 54 |
| 1975-06-02 | @ MON | 52 | L 3-5 | 30-22 | 2 | 11,427 | Doug Rau | Woodie Fryman | Woodie Fryman | Doug Rau | | 234 | 182 | 52 |
| 1975-06-03 | @ MON | 53 | W 6-5 | 31-22 | 2 | 10,498 | Don Sutton | Steve Renko | Don Sutton | Steve Renko | Jim Brewer | 240 | 187 | 53 |
| 1975-06-04 | @ MON | 54 | W 3-0 | 32-22 | 1 | 13,958 | Andy Messersmith | Dennis Blair | Andy Messersmith | Dennis Blair | | 243 | 187 | 56 |
| 1975-06-06 | @ PHI | 55 | W 3-2 | 33-22 | 1 | 38,357 | Burt Hooton | Tom Underwood | Burt Hooton | Tom Underwood | Mike Marshall | 246 | 189 | 57 |
| 1975-06-07 | @ PHI | 56 | L 0-4 | 33-23 | 2 | 41,094 | Doug Rau | Steve Carlton | Steve Carlton | Doug Rau | | 246 | 193 | 53 |
| 1975-06-08 | @ PHI | 57 | L 2-4 | 33-24 | 2 | 41,334 | Don Sutton | Jim Lonborg | Jim Lonborg | Don Sutton | | 248 | 197 | 51 |
| 1975-06-09 | vs MON | 58 | W 4-0 | 34-24 | 2 | 22,701 | Andy Messersmith | Woodie Fryman | Andy Messersmith | Woodie Fryman | | 252 | 197 | 55 |
| 1975-06-10 | vs MON | 59 | L 4-5 | 34-25 | 2 | 22,065 | Burt Hooton | Steve Renko | Steve Renko | Mike Marshall | Chuck Taylor | 256 | 202 | 54 |
| 1975-06-11 | vs NYN | 60 | L 1-2 | 34-26 | 2 | 40,095 | Doug Rau | Randy Tate | Bob Apodaca | Mike Marshall | | 257 | 204 | 53 |
| 1975-06-12 | vs NYN | 61 | L 0-2 | 34-27 | 2 | 27,240 | Don Sutton | Jon Matlack | Jon Matlack | Don Sutton | | 257 | 206 | 51 |
| 1975-06-13 | vs PHI | 62 | L 1-5 | 34-28 | 2 | 33,970 | Andy Messersmith | Jim Lonborg | Jim Lonborg | Andy Messersmith | | 258 | 211 | 47 |
| 1975-06-14 | vs PHI | 63 | W 4-3 | 35-28 | 2 | 52,299 | Burt Hooton | Larry Christenson | Burt Hooton | Tug McGraw | Mike Marshall | 262 | 214 | 48 |
| 1975-06-15 | vs PHI | 64 | L 3-4 | 35-29 | 2 | 40,959 | Doug Rau | Tom Underwood | Gene Garber | Mike Marshall | | 265 | 218 | 47 |
| 1975-06-16 | vs HOU | 65 | W 4-2 | 36-29 | 2 | 24,460 | Don Sutton | Larry Dierker | Don Sutton | Larry Dierker | | 269 | 220 | 49 |
| 1975-06-17 | vs HOU | 66 | W 6-1 | 37-29 | 2 | 25,586 | Andy Messersmith | Dave Roberts | Andy Messersmith | Dave Roberts | | 275 | 221 | 54 |
| 1975-06-18 | vs HOU | 67 | W 4-0 | 38-29 | 2 | 47,416 | Burt Hooton | Tom Griffin | Burt Hooton | Tom Griffin | | 279 | 221 | 58 |
| 1975-06-19 | @ SDN | 68 | W 4-1 | 39-29 | 2 | 21,533 | Doug Rau | Randy Jones | Doug Rau | Randy Jones | Mike Marshall | 283 | 222 | 61 |
| 1975-06-20 | @ SDN | 69 | L 1-2 | 39-30 | 2 | 22,822 | Don Sutton | Brent Strom | Brent Strom | Don Sutton | | 284 | 224 | 60 |
| 1975-06-21 | @ SDN | 70 | W 4-3 | 40-30 | 2 | 29,988 | Andy Messersmith | Rich Folkers | Andy Messersmith | Rich Folkers | | 288 | 227 | 61 |
| 1975-06-22 | @ SDN | 71 | W 3-2 | 41-30 | 2 | 32,176 | Al Downing | Dave Freisleben | Mike Marshall | Danny Frisella | | 291 | 229 | 62 |
| 1975-06-23 | @ HOU | 72 | L 5-6 | 41-31 | 2 | 12,472 | Burt Hooton | Dave Roberts | Dave Roberts | Burt Hooton | Wayne Granger | 296 | 235 | 61 |
| 1975-06-24 | @ HOU | 73 | W 8-3 | 42-31 | 2 | 14,285 | Doug Rau | Tom Griffin | Doug Rau | Tom Griffin | | 304 | 238 | 66 |
| 1975-06-25 | @ HOU | 74 | L 4-5 | 42-32 | 2 | 12,969 | Don Sutton | Doug Konieczny | Wayne Granger | Don Sutton | | 308 | 243 | 65 |
| 1975-06-26 | @ SFN | 75 | L 0-2 | 42-33 | 2 | 6,989 | Andy Messersmith | Ed Halicki | Ed Halicki | Andy Messersmith | | 308 | 245 | 63 |
| 1975-06-27 | @ SFN | 76 | L 5-10 | 42-34 | 2 | 12,387 | Burt Hooton | Pete Falcone | Charlie Williams | Burt Hooton | Randy Moffitt | 313 | 255 | 58 |
| 1975-06-28 | @ SFN | 77 | L 1-2 | 42-35 | 2 | 13,022 | Doug Rau | John Montefusco | John Montefusco | Doug Rau | Randy Moffitt | 314 | 257 | 57 |
| 1975-06-29 | @ SFN | 78 | L 2-5 | 42-36 | 2 | 25,929 | Don Sutton | Tom Bradley | Tom Bradley | Don Sutton | Randy Moffitt | 316 | 262 | 54 |
| 1975-06-30 | vs SDN | 79 | W 4-1 | 43-36 | 2 | 29,678 | Andy Messersmith | Rich Folkers | Andy Messersmith | Rich Folkers | | 320 | 263 | 57 |
| 1975-07-01 | vs SDN | 80 | L 1-10 | 43-37 | 2 | 21,542 | Burt Hooton | Dan Spillner | Dan Spillner | Burt Hooton | | 321 | 273 | 48 |
| 1975-07-02 | vs SDN | 81 | W 6-5 | 44-37 | 2 | 21,483 | Doug Rau | Dave Freisleben | Al Downing | Joe McIntosh | | 327 | 278 | 49 |
| 1975-07-03 | vs SFN | 82 | W 7-1 | 45-37 | 2 | 35,929 | Don Sutton | Pete Falcone | Don Sutton | Pete Falcone | | 334 | 279 | 55 |
| 1975-07-04 | vs SFN | 83 | L 0-1 | 45-38 | 2 | 52,621 | Andy Messersmith | John Montefusco | John Montefusco | Andy Messersmith | | 334 | 280 | 54 |
| 1975-07-05 | vs SFN | 84 | W 5-4 | 46-38 | 2 | 36,200 | Burt Hooton | Jim Barr | Al Downing | Ed Halicki | Mike Marshall | 339 | 284 | 55 |
| 1975-07-06 | vs SFN | 85 | W 5-1 | 47-38 | 2 | 33,235 | Doug Rau | Tom Bradley | Doug Rau | Tom Bradley | | 344 | 285 | 59 |
| 1975-07-08 | @ PIT | 86 | W 3-0 | 48-38 | 2 | 29,376 | Don Sutton | Dock Ellis | Don Sutton | Dock Ellis | Mike Marshall | 347 | 285 | 62 |
| 1975-07-09 | @ PIT | 87 | L 2-3 | 48-39 | 2 | 22,163 | Andy Messersmith | Bruce Kison | Bruce Kison | Andy Messersmith | Dave Giusti | 349 | 288 | 61 |
| 1975-07-10 | @ PIT | 88 | L 1-4 | 48-40 | 2 | 18,521 | Burt Hooton | Jerry Reuss | Jerry Reuss | Burt Hooton | Dave Giusti | 350 | 292 | 58 |
| 1975-07-11 | @ SLN | 89 | W 6-5 | 49-40 | 2 | 32,007 | Doug Rau | Bob Forsch | Mike Marshall | Mike Garman | | 356 | 297 | 59 |
| 1975-07-12 | @ SLN | 90 | L 1-2 | 49-41 | 2 | 31,606 | Al Downing | Lynn McGlothen | Al Hrabosky | Rick Rhoden | | 357 | 299 | 58 |
| 1975-07-13 | @ SLN | 91 | L 1-2 | 49-42 | 2 | 32,567 | Andy Messersmith | Ron Reed | Al Hrabosky | Mike Marshall | | 358 | 301 | 57 |
| 1975-07-17 | vs PIT | 92 | L 2-5 | 49-43 | 2 | 32,806 | Andy Messersmith | Bruce Kison | Bruce Kison | Andy Messersmith | Dave Giusti | 360 | 306 | 54 |
| 1975-07-18 | vs PIT | 93 | W 4-3 | 50-43 | 2 | 52,506 | Doug Rau | Dock Ellis | Mike Marshall | Larry Demery | | 364 | 309 | 55 |
| 1975-07-19 | vs PIT | 94 | L 3-5 | 50-44 | 2 | 51,591 | Don Sutton | Jerry Reuss | Dave Giusti | Mike Marshall | | 367 | 314 | 53 |
| 1975-07-20 | vs CHN | 95 | W 5-3 | 51-44 | 2 | 42,800 | Burt Hooton | Bill Bonham | Mike Marshall | Tom Dettore | | 372 | 317 | 55 |
| 1975-07-21 | vs CHN | 96 | L 0-1 | 51-45 | 2 | 24,147 | Andy Messersmith | Rick Reuschel | Rick Reuschel | Andy Messersmith | Oscar Zamora | 372 | 318 | 54 |
| 1975-07-22 | vs SLN | 97 | L 3-4 | 51-46 | 2 | 25,958 | Doug Rau | John Denny | Al Hrabosky | Mike Marshall | | 375 | 322 | 53 |
| 1975-07-23 | vs SLN | 98 | L 4-5 | 51-47 | 2 | 27,772 | Don Sutton | Bob Forsch | Bob Forsch | Don Sutton | Mike Garman | 379 | 327 | 52 |
| 1975-07-24 | vs SLN | 99 | W 8-2 | 52-47 | 2 | 26,982 | Burt Hooton | Lynn McGlothen | Burt Hooton | Lynn McGlothen | | 387 | 329 | 58 |
| 1975-07-25 | @ CIN | 100 | W 4-3 | 53-48 | 2 | 0 | Andy Messersmith | Clay Kirby | Andy Messersmith | Clay Carroll | Mike Marshall | 391 | 332 | 59 |
| 1975-07-25 | @ CIN | 101 | L 3-6 | 53-48 | 2 | 51,087 | Al Downing | Pat Darcy | Pat Darcy | Mike Marshall | Pedro Borbon | 394 | 338 | 56 |
| 1975-07-26 | @ CIN | 102 | L 3-5 | 53-49 | 2 | 50,236 | Doug Rau | Jack Billingham | Jack Billingham | Doug Rau | Rawly Eastwick | 397 | 343 | 54 |
| 1975-07-27 | @ CIN | 103 | W 5-3 | 54-49 | 2 | 50,609 | Don Sutton | Tom Carroll | Don Sutton | Tom Carroll | Mike Marshall | 402 | 346 | 56 |
| 1975-07-28 | @ ATL | 104 | L 3-5 | 54-50 | 2 | 6,328 | Burt Hooton | Phil Niekro | Phil Niekro | Mike Marshall | | 405 | 351 | 54 |
| 1975-07-29 | @ ATL | 105 | L 2-4 | 54-51 | 2 | 4,906 | Andy Messersmith | Blue Moon Odom | Blue Moon Odom | Andy Messersmith | Tom House | 407 | 355 | 52 |
| 1975-07-30 | @ ATL | 106 | W 8-2 | 55-51 | 2 | 3,954 | Doug Rau | Carl Morton | Doug Rau | Carl Morton | Mike Marshall | 415 | 357 | 58 |
| 1975-07-31 | @ ATL | 107 | L 10-11 | 55-52 | 2 | 3,934 | Al Downing | Bruce Dal Canton | Tom House | Mike Marshall | | 425 | 368 | 57 |
| 1975-08-01 | vs CIN | 108 | W 5-3 | 56-52 | 2 | 50,331 | Don Sutton | Jack Billingham | Charlie Hough | Pedro Borbon | | 430 | 371 | 59 |
| 1975-08-02 | vs CIN | 109 | L 0-1 | 56-53 | 2 | 52,015 | Andy Messersmith | Tom Carroll | Tom Carroll | Andy Messersmith | Clay Carroll | 430 | 372 | 58 |
| 1975-08-03 | vs CIN | 110 | L 1-3 | 56-54 | 2 | 51,667 | Doug Rau | Pat Darcy | Pat Darcy | Doug Rau | Rawly Eastwick | 431 | 375 | 56 |
| 1975-08-04 | vs ATL | 111 | W 9-1 | 57-54 | 2 | 25,036 | Burt Hooton | Bruce Dal Canton | Burt Hooton | Bruce Dal Canton | | 440 | 376 | 64 |
| 1975-08-05 | vs ATL | 112 | W 5-0 | 58-54 | 2 | 24,452 | Don Sutton | Phil Niekro | Don Sutton | Phil Niekro | | 445 | 376 | 69 |
| 1975-08-06 | vs ATL | 113 | L 4-5 | 58-55 | 2 | 23,779 | Andy Messersmith | Blue Moon Odom | Tom House | Andy Messersmith | Max Leon | 449 | 381 | 68 |
| 1975-08-08 | @ NYN | 114 | W 4-3 | 59-55 | 2 | 42,049 | Doug Rau | Randy Tate | Mike Marshall | Ken Sanders | | 453 | 384 | 69 |
| 1975-08-09 | @ NYN | 115 | W 2-0 | 60-55 | 2 | 36,421 | Burt Hooton | Jerry Koosman | Burt Hooton | Jerry Koosman | | 455 | 384 | 71 |
| 1975-08-10 | @ NYN | 116 | W 2-1 | 61-55 | 2 | 39,915 | Don Sutton | Hank Webb | Don Sutton | Hank Webb | | 457 | 385 | 72 |
| 1975-08-11 | @ PHI | 117 | W 7-1 | 62-55 | 2 | 33,175 | Andy Messersmith | Larry Christenson | Andy Messersmith | Larry Christenson | | 464 | 386 | 78 |
| 1975-08-12 | @ PHI | 118 | W 7-6 | 63-55 | 2 | 36,512 | Doug Rau | Tom Underwood | Mike Marshall | Gene Garber | | 471 | 392 | 79 |
| 1975-08-13 | @ PHI | 119 | W 5-4 | 64-55 | 2 | 34,919 | Burt Hooton | Steve Carlton | Burt Hooton | Steve Carlton | Mike Marshall | 476 | 396 | 80 |
| 1975-08-15 | @ MON | 120 | L 4-8 | 64-56 | 2 | 16,574 | Don Sutton | Steve Rogers | Steve Rogers | Don Sutton | | 480 | 404 | 76 |
| 1975-08-16 | @ MON | 121 | L 2-3 | 64-57 | 2 | 21,682 | Andy Messersmith | Don Carrithers | Dale Murray | Mike Marshall | | 482 | 407 | 75 |
| 1975-08-17 | @ MON | 122 | W 5-3 | 65-57 | 2 | 19,125 | Doug Rau | Steve Renko | Doug Rau | Steve Renko | Mike Marshall | 487 | 410 | 77 |
| 1975-08-18 | @ CHN | 123 | W 3-1 | 66-57 | 2 | 14,383 | Burt Hooton | Steve Stone | Burt Hooton | Steve Stone | Mike Marshall | 490 | 411 | 79 |
| 1975-08-19 | @ CHN | 124 | W 2-1 | 67-57 | 2 | 17,594 | Don Sutton | Bill Bonham | Mike Marshall | Bill Bonham | | 492 | 412 | 80 |
| 1975-08-21 | @ CHN | 125 | L 0-7 | 67-58 | 2 | 8,377 | Andy Messersmith | Rick Reuschel | Rick Reuschel | Andy Messersmith | | 492 | 419 | 73 |
| 1975-08-22 | vs MON | 126 | L 1-3 | 67-59 | 2 | 22,046 | Doug Rau | Dan Warthen | Dale Murray | Al Downing | | 493 | 422 | 71 |
| 1975-08-23 | vs MON | 127 | W 3-1 | 68-60 | 2 | 0 | Burt Hooton | Steve Rogers | Burt Hooton | Steve Rogers | Mike Marshall | 496 | 423 | 73 |
| 1975-08-23 | vs MON | 128 | L 2-5 | 68-60 | 2 | 35,050 | Rick Rhoden | Steve Renko | Dale Murray | Mike Marshall | | 498 | 428 | 70 |
| 1975-08-24 | vs MON | 129 | L 3-5 | 68-61 | 2 | 35,305 | Don Sutton | Don Carrithers | Dale Murray | Mike Marshall | Chuck Taylor | 501 | 433 | 68 |
| 1975-08-25 | vs PHI | 130 | L 2-4 | 68-62 | 2 | 20,048 | Andy Messersmith | Larry Christenson | Larry Christenson | Andy Messersmith | Gene Garber | 503 | 437 | 66 |
| 1975-08-26 | vs PHI | 131 | W 8-1 | 69-62 | 2 | 20,273 | Doug Rau | Tom Underwood | Doug Rau | Tom Underwood | | 511 | 438 | 73 |
| 1975-08-27 | vs PHI | 132 | W 10-0 | 70-62 | 2 | 20,753 | Burt Hooton | Steve Carlton | Burt Hooton | Steve Carlton | | 521 | 438 | 83 |
| 1975-08-28 | vs NYN | 133 | L 1-4 | 70-63 | 2 | 20,970 | Rick Rhoden | Jerry Koosman | Jerry Koosman | Rick Rhoden | | 522 | 442 | 80 |
| 1975-08-29 | vs NYN | 134 | L 1-6 | 70-64 | 2 | 27,401 | Don Sutton | Jon Matlack | Jon Matlack | Don Sutton | | 523 | 448 | 75 |
| 1975-08-30 | vs NYN | 135 | W 7-0 | 71-64 | 2 | 21,584 | Andy Messersmith | Hank Webb | Andy Messersmith | Hank Webb | | 530 | 448 | 82 |
| 1975-08-31 | vs NYN | 136 | W 5-2 | 72-64 | 2 | 24,798 | Doug Rau | Craig Swan | Doug Rau | Craig Swan | Charlie Hough | 535 | 450 | 85 |
| 1975-09-01 | @ SFN | 137 | W 3-1 | 73-64 | 2 | 9,996 | Burt Hooton | Jim Barr | Burt Hooton | Charlie Williams | | 538 | 451 | 87 |
| 1975-09-02 | @ SFN | 138 | L 3-7 | 73-65 | 2 | 5,098 | Don Sutton | Ed Halicki | Ed Halicki | Don Sutton | | 541 | 458 | 83 |
| 1975-09-03 | @ CIN | 139 | L 2-13 | 73-66 | 2 | 27,881 | Andy Messersmith | Gary Nolan | Gary Nolan | Andy Messersmith | | 543 | 471 | 72 |
| 1975-09-04 | @ CIN | 140 | W 3-2 | 74-66 | 2 | 29,512 | Doug Rau | Clay Kirby | Doug Rau | Clay Kirby | | 546 | 473 | 73 |
| 1975-09-05 | @ ATL | 141 | W 5-2 | 75-66 | 2 | 2,725 | Burt Hooton | Mike Thompson | Burt Hooton | Mike Thompson | | 551 | 475 | 76 |
| 1975-09-06 | @ ATL | 142 | L 2-3 | 75-67 | 2 | 7,357 | Rick Rhoden | Carl Morton | Carl Morton | Charlie Hough | Bruce Dal Canton | 553 | 478 | 75 |
| 1975-09-07 | @ ATL | 143 | L 4-5 | 75-68 | 2 | 3,439 | Don Sutton | Jamie Easterly | Bruce Dal Canton | Charlie Hough | | 557 | 483 | 74 |
| 1975-09-08 | vs SFN | 144 | W 4-0 | 76-68 | 2 | 17,239 | Andy Messersmith | John Montefusco | Andy Messersmith | John Montefusco | | 561 | 483 | 78 |
| 1975-09-09 | vs SFN | 145 | W 8-3 | 77-68 | 2 | 14,344 | Doug Rau | Jim Barr | Charlie Hough | Jim Barr | | 569 | 486 | 83 |
| 1975-09-10 | vs CIN | 146 | W 3-2 | 78-68 | 2 | 27,432 | Burt Hooton | Pat Darcy | Burt Hooton | Rawly Eastwick | | 572 | 488 | 84 |
| 1975-09-11 | vs CIN | 147 | W 5-2 | 79-68 | 2 | 27,640 | Rick Rhoden | Jack Billingham | Rick Rhoden | Jack Billingham | | 577 | 490 | 87 |
| 1975-09-12 | vs ATL | 148 | L 1-2 | 79-69 | 2 | 18,067 | Don Sutton | Phil Niekro | Phil Niekro | Don Sutton | | 578 | 492 | 86 |
| 1975-09-13 | vs ATL | 149 | W 6-0 | 80-69 | 2 | 17,929 | Andy Messersmith | Frank LaCorte | Andy Messersmith | Frank LaCorte | | 584 | 492 | 92 |
| 1975-09-14 | vs ATL | 150 | W 3-2 | 81-69 | 2 | 14,833 | Doug Rau | Carl Morton | Doug Rau | Carl Morton | Charlie Hough | 587 | 494 | 93 |
| 1975-09-15 | vs SDN | 151 | W 5-4 | 82-69 | 2 | 12,233 | Burt Hooton | Rich Folkers | Burt Hooton | Joe McIntosh | | 592 | 498 | 94 |
| 1975-09-16 | vs SDN | 152 | W 5-2 | 83-69 | 2 | 12,032 | Rick Rhoden | Brent Strom | Rick Rhoden | Brent Strom | Charlie Hough | 597 | 500 | 97 |
| 1975-09-17 | vs SDN | 153 | W 7-1 | 84-69 | 2 | 13,465 | Andy Messersmith | Dan Spillner | Andy Messersmith | Dan Spillner | | 604 | 501 | 103 |
| 1975-09-19 | @ HOU | 154 | L 5-6 | 84-70 | 2 | 11,160 | Doug Rau | Doug Konieczny | Dave Roberts | Dave Sells | | 609 | 507 | 102 |
| 1975-09-20 | @ HOU | 155 | W 5-4 | 85-70 | 2 | 12,703 | Burt Hooton | Jose Sosa | Charlie Hough | Paul Siebert | | 614 | 511 | 103 |
| 1975-09-21 | @ HOU | 156 | L 1-4 | 85-71 | 2 | 8,909 | Rick Rhoden | J.R. Richard | J.R. Richard | Rick Rhoden | | 615 | 515 | 100 |
| 1975-09-22 | @ SDN | 157 | L 5-6 | 85-72 | 2 | 5,880 | Andy Messersmith | Dave Freisleben | Butch Metzger | Dave Sells | | 620 | 521 | 99 |
| 1975-09-23 | @ SDN | 158 | L 4-6 | 85-73 | 2 | 13,565 | Al Downing | Randy Jones | Randy Jones | Stan Wall | | 624 | 527 | 97 |
| 1975-09-24 | @ SDN | 159 | W 14-0 | 86-73 | 2 | 9,262 | Doug Rau | Rich Folkers | Doug Rau | Rich Folkers | | 638 | 527 | 111 |
| 1975-09-26 | vs HOU | 160 | W 3-2 | 87-73 | 2 | 17,455 | Burt Hooton | J.R. Richard | Burt Hooton | J.R. Richard | | 641 | 529 | 112 |
| 1975-09-27 | vs HOU | 161 | W 5-1 | 88-73 | 2 | 13,529 | Andy Messersmith | Mike Stanton | Andy Messersmith | Mike Stanton | | 646 | 530 | 116 |
| 1975-09-28 | vs HOU | 162 | L 2-4 | 88-74 | 2 | 36,507 | Rick Rhoden | Jim York | Jim York | Charlie Hough | Paul Siebert | 648 | 534 | 114 |