| 1975-04-07 | vs ATL | 1 | W 6-2 | - | | 14,959 | Larry Dierker | Phil Niekro | Larry Dierker | Phil Niekro | | 6 | 2 | 4 |
| 1975-04-08 | vs ATL | 2 | L 0-2 | - | | 7,937 | Doug Konieczny | Carl Morton | Carl Morton | Doug Konieczny | | 6 | 4 | 2 |
| 1975-04-09 | vs ATL | 3 | W 14-2 | - | | 13,257 | J.R. Richard | Ron Reed | Dave Roberts | Ron Reed | | 20 | 6 | 14 |
| 1975-04-11 | vs LAN | 4 | L 0-7 | - | | 17,851 | Tom Griffin | Don Sutton | Don Sutton | Tom Griffin | | 20 | 13 | 7 |
| 1975-04-12 | vs LAN | 5 | W 7-5 | - | | 25,024 | Larry Dierker | Juan Marichal | Larry Dierker | Juan Marichal | Wayne Granger | 27 | 18 | 9 |
| 1975-04-13 | vs LAN | 6 | L 4-7 | - | | 17,310 | Doug Konieczny | Andy Messersmith | Andy Messersmith | Doug Konieczny | | 31 | 25 | 6 |
| 1975-04-15 | @ ATL | 7 | L 1-6 | - | | 12,774 | J.R. Richard | Phil Niekro | Phil Niekro | J.R. Richard | | 32 | 31 | 1 |
| 1975-04-16 | @ ATL | 8 | L 2-5 | - | | 3,401 | Larry Dierker | Buzz Capra | Buzz Capra | Larry Dierker | | 34 | 36 | -2 |
| 1975-04-17 | @ ATL | 9 | L 1-2 | - | | 3,123 | Dave Roberts | Carl Morton | Carl Morton | Dave Roberts | | 35 | 38 | -3 |
| 1975-04-18 | @ CIN | 10 | L 2-5 | - | | 36,485 | Tom Griffin | Don Gullett | Don Gullett | Tom Griffin | | 37 | 43 | -6 |
| 1975-04-19 | @ CIN | 11 | L 8-9 | - | | 17,178 | Doug Konieczny | Jack Billingham | Clay Carroll | Ken Forsch | | 45 | 52 | -7 |
| 1975-04-20 | @ CIN | 12 | L 3-5 | - | | 0 | Larry Dierker | Pat Darcy | Clay Carroll | Fred Scherman | | 48 | 57 | -9 |
| 1975-04-20 | @ CIN | 13 | W 7-6 | - | | 35,150 | J.R. Richard | Clay Kirby | J.R. Richard | Clay Kirby | Wayne Granger | 55 | 63 | -8 |
| 1975-04-21 | vs SDN | 14 | L 0-4 | - | | 6,523 | Jim Crawford | Randy Jones | Randy Jones | Jim Crawford | | 55 | 67 | -12 |
| 1975-04-22 | vs SDN | 15 | L 1-2 | - | | 5,300 | Tom Griffin | Dan Spillner | Dan Spillner | Tom Griffin | | 56 | 69 | -13 |
| 1975-04-23 | vs SFN | 16 | W 3-2 | - | | 0 | Doug Konieczny | John Montefusco | Doug Konieczny | John Montefusco | Ken Forsch | 59 | 71 | -12 |
| 1975-04-23 | vs SFN | 17 | L 0-3 | - | | 9,413 | Dave Roberts | Pete Falcone | Pete Falcone | Dave Roberts | | 59 | 74 | -15 |
| 1975-04-24 | vs SFN | 18 | L 5-6 | - | | 5,960 | J.R. Richard | Jim Barr | Gary Lavelle | Ken Forsch | Dave Heaverlo | 64 | 80 | -16 |
| 1975-04-25 | vs CIN | 19 | W 6-4 | - | | 11,162 | Larry Dierker | Pat Darcy | Larry Dierker | Pat Darcy | Ken Forsch | 70 | 84 | -14 |
| 1975-04-26 | vs CIN | 20 | L 3-9 | - | | 14,889 | Tom Griffin | Fred Norman | Fred Norman | Tom Griffin | | 73 | 93 | -20 |
| 1975-04-27 | vs CIN | 21 | L 2-6 | - | | 11,140 | Doug Konieczny | Gary Nolan | Pedro Borbon | Doug Konieczny | | 75 | 99 | -24 |
| 1975-04-28 | @ SDN | 22 | W 4-1 | - | | 19,080 | Dave Roberts | Joe McIntosh | Dave Roberts | Joe McIntosh | | 79 | 100 | -21 |
| 1975-04-29 | @ SDN | 23 | W 8-2 | - | | 7,840 | J.R. Richard | Dave Freisleben | J.R. Richard | Dave Freisleben | | 87 | 102 | -15 |
| 1975-04-30 | @ SDN | 24 | L 2-4 | - | | 8,077 | Larry Dierker | Sonny Siebert | Sonny Siebert | Larry Dierker | Bill Greif | 89 | 106 | -17 |
| 1975-05-01 | @ SDN | 25 | W 6-3 | - | | 11,885 | Ken Forsch | Randy Jones | Ken Forsch | Randy Jones | Jim Crawford | 95 | 109 | -14 |
| 1975-05-02 | @ SFN | 26 | L 4-5 | - | | 4,110 | Doug Konieczny | Mike Caldwell | Randy Moffitt | Jim York | | 99 | 114 | -15 |
| 1975-05-04 | @ SFN | 27 | L 6-8 | - | | 0 | Dave Roberts | John Montefusco | Jim Barr | Jim York | | 105 | 122 | -17 |
| 1975-05-04 | @ SFN | 28 | W 12-8 | - | | 9,451 | J.R. Richard | John D'Acquisto | J.R. Richard | John D'Acquisto | Wayne Granger | 117 | 130 | -13 |
| 1975-05-05 | @ LAN | 29 | L 0-2 | - | | 22,236 | Larry Dierker | Doug Rau | Doug Rau | Larry Dierker | | 117 | 132 | -15 |
| 1975-05-06 | @ LAN | 30 | L 1-3 | - | | 23,788 | Doug Konieczny | Don Sutton | Don Sutton | Doug Konieczny | | 118 | 135 | -17 |
| 1975-05-07 | @ LAN | 31 | L 1-5 | - | | 31,222 | Tom Griffin | Andy Messersmith | Andy Messersmith | Tom Griffin | | 119 | 140 | -21 |
| 1975-05-09 | @ MON | 32 | L 4-5 | - | | 10,630 | Dave Roberts | Woodie Fryman | Don DeMola | Dave Roberts | Dale Murray | 123 | 145 | -22 |
| 1975-05-10 | @ MON | 33 | L 7-8 | - | | 16,040 | J.R. Richard | Steve Renko | Dale Murray | Jim Crawford | John Montague | 130 | 153 | -23 |
| 1975-05-11 | @ MON | 34 | W 6-0 | - | | 10,416 | Larry Dierker | Dennis Blair | Larry Dierker | Dennis Blair | | 136 | 153 | -17 |
| 1975-05-13 | @ CHN | 35 | L 1-2 | - | | 9,164 | Doug Konieczny | Steve Stone | Steve Stone | Doug Konieczny | Oscar Zamora | 137 | 155 | -18 |
| 1975-05-14 | @ CHN | 36 | W 11-7 | - | | 8,087 | Tom Griffin | Ray Burris | Tom Griffin | Ray Burris | Joe Niekro | 148 | 162 | -14 |
| 1975-05-15 | @ CHN | 37 | L 2-4 | - | | 6,406 | J.R. Richard | Rick Reuschel | Rick Reuschel | J.R. Richard | | 150 | 166 | -16 |
| 1975-05-16 | vs NYN | 38 | L 2-10 | - | | 10,672 | Larry Dierker | Tom Seaver | Tom Seaver | Larry Dierker | | 152 | 176 | -24 |
| 1975-05-17 | vs NYN | 39 | L 4-6 | - | | 15,296 | Dave Roberts | Jon Matlack | Jon Matlack | Dave Roberts | Harry Parker | 156 | 182 | -26 |
| 1975-05-18 | vs NYN | 40 | W 12-7 | - | | 10,252 | Doug Konieczny | Randy Tate | Doug Konieczny | Randy Tate | Jim Crawford | 168 | 189 | -21 |
| 1975-05-19 | vs PHI | 41 | W 4-2 | - | | 7,049 | Tom Griffin | Steve Carlton | Tom Griffin | Steve Carlton | Wayne Granger | 172 | 191 | -19 |
| 1975-05-20 | vs PHI | 42 | W 4-2 | - | | 7,211 | J.R. Richard | Jim Lonborg | Ken Forsch | Tug McGraw | Joe Niekro | 176 | 193 | -17 |
| 1975-05-21 | vs PHI | 43 | W 4-0 | - | | 8,135 | Larry Dierker | Wayne Twitchell | Larry Dierker | Wayne Twitchell | | 180 | 193 | -13 |
| 1975-05-23 | vs MON | 44 | W 4-2 | - | | 9,143 | Dave Roberts | Dennis Blair | Dave Roberts | Dennis Blair | | 184 | 195 | -11 |
| 1975-05-24 | vs MON | 45 | L 1-2 | - | | 15,208 | Doug Konieczny | Steve Rogers | Steve Rogers | Doug Konieczny | | 185 | 197 | -12 |
| 1975-05-25 | vs MON | 46 | W 8-7 | - | | 10,459 | Tom Griffin | Dave McNally | Joe Niekro | Don DeMola | | 193 | 204 | -11 |
| 1975-05-26 | @ PIT | 47 | L 2-10 | - | | 11,126 | J.R. Richard | Bruce Kison | Bruce Kison | J.R. Richard | | 195 | 214 | -19 |
| 1975-05-27 | @ PIT | 48 | L 5-6 | - | | 7,003 | Larry Dierker | Jim Rooker | Larry Demery | Joe Niekro | | 200 | 220 | -20 |
| 1975-05-28 | @ PIT | 49 | L 0-3 | - | | 7,601 | Dave Roberts | Ken Brett | Ken Brett | Dave Roberts | | 200 | 223 | -23 |
| 1975-05-30 | @ PHI | 50 | W 5-0 | - | | 12,566 | Doug Konieczny | Jim Lonborg | Doug Konieczny | Jim Lonborg | | 205 | 223 | -18 |
| 1975-05-31 | @ PHI | 51 | W 15-3 | - | | 18,094 | J.R. Richard | Wayne Twitchell | J.R. Richard | Wayne Twitchell | | 220 | 226 | -6 |
| 1975-06-01 | @ PHI | 52 | L 4-5 | - | | 22,278 | Larry Dierker | Tom Underwood | Tom Underwood | Larry Dierker | Larry Christenson | 224 | 231 | -7 |
| 1975-06-02 | @ NYN | 53 | L 0-2 | - | | 13,003 | Dave Roberts | Jon Matlack | Jon Matlack | Dave Roberts | | 224 | 233 | -9 |
| 1975-06-03 | @ NYN | 54 | L 3-4 | - | | 8,666 | Ken Forsch | Tom Hall | Tom Hall | Ken Forsch | Bob Apodaca | 227 | 237 | -10 |
| 1975-06-04 | @ NYN | 55 | L 0-1 | - | | 15,442 | Doug Konieczny | Jerry Koosman | Jerry Koosman | Doug Konieczny | | 227 | 238 | -11 |
| 1975-06-05 | @ NYN | 56 | L 1-2 | - | | 12,477 | Tom Griffin | Tom Seaver | Tom Seaver | Tom Griffin | | 228 | 240 | -12 |
| 1975-06-06 | vs SLN | 57 | L 0-6 | - | | 12,955 | Larry Dierker | Bob Forsch | Bob Forsch | Larry Dierker | | 228 | 246 | -18 |
| 1975-06-07 | vs SLN | 58 | L 1-5 | - | | 13,990 | Dave Roberts | Lynn McGlothen | Lynn McGlothen | Dave Roberts | | 229 | 251 | -22 |
| 1975-06-08 | vs SLN | 59 | L 1-5 | - | | 12,288 | Ken Forsch | Ron Reed | Ron Reed | Ken Forsch | Al Hrabosky | 230 | 256 | -26 |
| 1975-06-09 | vs CHN | 60 | L 3-4 | - | | 3,427 | Tom Griffin | Steve Stone | Oscar Zamora | Wayne Granger | Darold Knowles | 233 | 260 | -27 |
| 1975-06-10 | vs CHN | 61 | W 4-3 | - | | 7,542 | Doug Konieczny | Bill Bonham | Doug Konieczny | Eddie Watt | | 237 | 263 | -26 |
| 1975-06-11 | vs PIT | 62 | W 5-1 | - | | 10,125 | Larry Dierker | Bruce Kison | Larry Dierker | Bruce Kison | | 242 | 264 | -22 |
| 1975-06-12 | vs PIT | 63 | L 2-4 | - | | 10,802 | Dave Roberts | Dock Ellis | Dock Ellis | Dave Roberts | Larry Demery | 244 | 268 | -24 |
| 1975-06-13 | @ SLN | 64 | L 2-6 | - | | 20,557 | Paul Siebert | Ron Reed | Ron Reed | Paul Siebert | | 246 | 274 | -28 |
| 1975-06-14 | @ SLN | 65 | W 9-0 | - | | 25,122 | Tom Griffin | John Curtis | Tom Griffin | John Curtis | | 255 | 274 | -19 |
| 1975-06-15 | @ SLN | 66 | W 8-7 | - | | 33,201 | Doug Konieczny | Bob Forsch | Joe Niekro | Mike Garman | | 263 | 281 | -18 |
| 1975-06-16 | @ LAN | 67 | L 2-4 | - | | 24,460 | Larry Dierker | Don Sutton | Don Sutton | Larry Dierker | | 265 | 285 | -20 |
| 1975-06-17 | @ LAN | 68 | L 1-6 | - | | 25,586 | Dave Roberts | Andy Messersmith | Andy Messersmith | Dave Roberts | | 266 | 291 | -25 |
| 1975-06-18 | @ LAN | 69 | L 0-4 | - | | 47,416 | Tom Griffin | Burt Hooton | Burt Hooton | Tom Griffin | | 266 | 295 | -29 |
| 1975-06-20 | vs CIN | 70 | L 3-7 | - | | 19,357 | Doug Konieczny | Tom Carroll | Tom Carroll | Doug Konieczny | | 269 | 302 | -33 |
| 1975-06-21 | vs CIN | 71 | L 6-7 | - | | 24,317 | J.R. Richard | Clay Carroll | Fred Norman | Joe Niekro | | 275 | 309 | -34 |
| 1975-06-22 | vs CIN | 72 | W 8-4 | - | | 18,871 | Larry Dierker | Gary Nolan | Larry Dierker | Gary Nolan | | 283 | 313 | -30 |
| 1975-06-23 | vs LAN | 73 | W 6-5 | - | | 12,472 | Dave Roberts | Burt Hooton | Dave Roberts | Burt Hooton | Wayne Granger | 289 | 318 | -29 |
| 1975-06-24 | vs LAN | 74 | L 3-8 | - | | 14,285 | Tom Griffin | Doug Rau | Doug Rau | Tom Griffin | | 292 | 326 | -34 |
| 1975-06-25 | vs LAN | 75 | W 5-4 | - | | 12,969 | Doug Konieczny | Don Sutton | Wayne Granger | Don Sutton | | 297 | 330 | -33 |
| 1975-06-26 | vs ATL | 76 | W 8-4 | - | | 7,017 | J.R. Richard | Mike Thompson | J.R. Richard | Mike Thompson | | 305 | 334 | -29 |
| 1975-06-27 | vs ATL | 77 | L 4-7 | - | | 10,222 | Larry Dierker | Jamie Easterly | Jamie Easterly | Larry Dierker | Max Leon | 309 | 341 | -32 |
| 1975-06-28 | vs ATL | 78 | L 3-6 | - | | 10,999 | Dave Roberts | Phil Niekro | Mike Beard | Dave Roberts | Tom House | 312 | 347 | -35 |
| 1975-06-29 | vs ATL | 79 | L 1-3 | - | | 10,576 | Ken Forsch | Carl Morton | Carl Morton | Ken Forsch | Max Leon | 313 | 350 | -37 |
| 1975-06-30 | @ CIN | 80 | L 6-9 | - | | 22,708 | Doug Konieczny | Tom Carroll | Clay Kirby | Joe Niekro | | 319 | 359 | -40 |
| 1975-07-01 | @ CIN | 81 | L 7-8 | - | | 22,707 | J.R. Richard | Fred Norman | Pat Darcy | Joe Niekro | | 326 | 367 | -41 |
| 1975-07-02 | @ CIN | 82 | L 3-4 | - | | 23,080 | Larry Dierker | Tom Carroll | Rawly Eastwick | Larry Dierker | | 329 | 371 | -42 |
| 1975-07-04 | @ ATL | 83 | L 4-5 | - | | 29,487 | Dave Roberts | Carl Morton | Carl Morton | Wayne Granger | | 333 | 376 | -43 |
| 1975-07-05 | @ ATL | 84 | L 3-4 | - | | 0 | Ken Forsch | Ray Sadecki | Ray Sadecki | Ken Forsch | Elias Sosa | 336 | 380 | -44 |
| 1975-07-05 | @ ATL | 85 | L 4-8 | - | | 11,202 | Doug Konieczny | Max Leon | Max Leon | Doug Konieczny | Tom House | 340 | 388 | -48 |
| 1975-07-06 | @ ATL | 86 | W 6-2 | - | | 3,728 | J.R. Richard | Phil Niekro | J.R. Richard | Phil Niekro | Jim Crawford | 346 | 390 | -44 |
| 1975-07-07 | vs MON | 87 | W 5-1 | - | | 8,100 | Larry Dierker | Steve Rogers | Larry Dierker | Steve Rogers | | 351 | 391 | -40 |
| 1975-07-08 | vs MON | 88 | W 5-1 | - | | 9,542 | Dave Roberts | Steve Renko | Dave Roberts | Steve Renko | | 356 | 392 | -36 |
| 1975-07-09 | vs MON | 89 | W 4-3 | - | | 9,304 | Ken Forsch | Dennis Blair | Wayne Granger | Don DeMola | | 360 | 395 | -35 |
| 1975-07-11 | vs PHI | 90 | L 1-2 | - | | 16,394 | Doug Konieczny | Larry Christenson | Larry Christenson | Doug Konieczny | | 361 | 397 | -36 |
| 1975-07-12 | vs PHI | 91 | L 2-14 | - | | 14,520 | J.R. Richard | Steve Carlton | Steve Carlton | J.R. Richard | | 363 | 411 | -48 |
| 1975-07-13 | vs PHI | 92 | W 9-5 | - | | 12,870 | Larry Dierker | Tom Underwood | Ken Forsch | Tom Underwood | Dave Roberts | 372 | 416 | -44 |
| 1975-07-17 | @ PHI | 93 | L 5-6 | - | | 18,026 | Doug Konieczny | Steve Carlton | Tug McGraw | Ken Forsch | | 377 | 422 | -45 |
| 1975-07-18 | @ PHI | 94 | L 4-7 | - | | 24,072 | J.R. Richard | Jim Lonborg | Tom Hilgendorf | J.R. Richard | Gene Garber | 381 | 429 | -48 |
| 1975-07-19 | @ PHI | 95 | L 0-1 | - | | 30,983 | Larry Dierker | Larry Christenson | Larry Christenson | Larry Dierker | | 381 | 430 | -49 |
| 1975-07-20 | @ NYN | 96 | L 9-10 | - | | 20,242 | Dave Roberts | Randy Tate | Tom Hall | Wayne Granger | Harry Parker | 390 | 440 | -50 |
| 1975-07-21 | @ NYN | 97 | W 6-2 | - | | 13,414 | Ken Forsch | George Stone | Ken Forsch | George Stone | | 396 | 442 | -46 |
| 1975-07-22 | @ MON | 98 | L 1-2 | - | | 12,148 | Doug Konieczny | Steve Rogers | Dale Murray | Jose Sosa | | 397 | 444 | -47 |
| 1975-07-23 | @ MON | 99 | W 2-1 | - | | 16,804 | J.R. Richard | Dennis Blair | J.R. Richard | Dennis Blair | | 399 | 445 | -46 |
| 1975-07-24 | @ MON | 100 | W 6-5 | - | | 7,185 | Larry Dierker | Steve Renko | Larry Dierker | Steve Renko | Mike Cosgrove | 405 | 450 | -45 |
| 1975-07-25 | vs SFN | 101 | L 1-8 | - | | 14,452 | Dave Roberts | Jim Barr | Jim Barr | Dave Roberts | | 406 | 458 | -52 |
| 1975-07-26 | vs SFN | 102 | L 2-3 | - | | 0 | Ken Forsch | Pete Falcone | Randy Moffitt | Ken Forsch | Gary Lavelle | 408 | 461 | -53 |
| 1975-07-26 | vs SFN | 103 | L 3-9 | - | | 24,736 | Doug Konieczny | Tom Bradley | Tom Bradley | Doug Konieczny | Charlie Williams | 411 | 470 | -59 |
| 1975-07-27 | vs SFN | 104 | L 1-3 | - | | 10,117 | J.R. Richard | John Montefusco | John Montefusco | J.R. Richard | Gary Lavelle | 412 | 473 | -61 |
| 1975-07-28 | vs SDN | 105 | L 0-2 | - | | 6,826 | Larry Dierker | Dave Freisleben | Dave Freisleben | Larry Dierker | | 412 | 475 | -63 |
| 1975-07-29 | vs SDN | 106 | W 6-2 | - | | 7,156 | Dave Roberts | Dan Spillner | Dave Roberts | Dan Spillner | | 418 | 477 | -59 |
| 1975-07-30 | vs SDN | 107 | W 8-4 | - | | 7,547 | Doug Konieczny | Joe McIntosh | Doug Konieczny | Joe McIntosh | Jose Sosa | 426 | 481 | -55 |
| 1975-07-31 | vs SDN | 108 | L 3-5 | - | | 7,475 | Ken Forsch | Jerry Johnson | Dave Tomlin | Wayne Granger | Bill Greif | 429 | 486 | -57 |
| 1975-08-01 | @ SFN | 109 | L 2-3 | - | | 2,653 | J.R. Richard | Ed Halicki | Ed Halicki | J.R. Richard | | 431 | 489 | -58 |
| 1975-08-02 | @ SFN | 110 | L 7-8 | - | | 5,339 | Larry Dierker | Jim Barr | Dave Heaverlo | Jim Crawford | | 438 | 497 | -59 |
| 1975-08-03 | @ SFN | 111 | L 4-5 | - | | 0 | Dave Roberts | Pete Falcone | Pete Falcone | Dave Roberts | Randy Moffitt | 442 | 502 | -60 |
| 1975-08-03 | @ SFN | 112 | W 10-9 | - | | 12,450 | Doug Konieczny | Tom Bradley | Jim Crawford | Mike Caldwell | Mike Cosgrove | 452 | 511 | -59 |
| 1975-08-04 | @ SDN | 113 | W 5-3 | - | | 15,000 | Joe Niekro | Dave Freisleben | Joe Niekro | Dave Freisleben | Mike Cosgrove | 457 | 514 | -57 |
| 1975-08-05 | @ SDN | 114 | L 5-6 | - | | 6,874 | J.R. Richard | Jerry Johnson | Bill Greif | Wayne Granger | | 462 | 520 | -58 |
| 1975-08-06 | @ SDN | 115 | L 1-6 | - | | 16,661 | Larry Dierker | Randy Jones | Randy Jones | Larry Dierker | | 463 | 526 | -63 |
| 1975-08-07 | vs PIT | 116 | W 6-1 | - | | 15,255 | Dave Roberts | Bruce Kison | Dave Roberts | Bruce Kison | | 469 | 527 | -58 |
| 1975-08-08 | vs PIT | 117 | W 5-3 | - | | 14,889 | Doug Konieczny | Dock Ellis | Jim Crawford | Kent Tekulve | | 474 | 530 | -56 |
| 1975-08-09 | vs PIT | 118 | W 5-0 | - | | 13,531 | Joe Niekro | Jerry Reuss | Joe Niekro | Jerry Reuss | | 479 | 530 | -51 |
| 1975-08-10 | vs PIT | 119 | W 5-3 | - | | 12,243 | J.R. Richard | Jim Rooker | J.R. Richard | Jim Rooker | Mike Cosgrove | 484 | 533 | -49 |
| 1975-08-11 | vs SLN | 120 | W 7-2 | - | | 10,550 | Larry Dierker | John Curtis | Larry Dierker | John Curtis | | 491 | 535 | -44 |
| 1975-08-12 | vs SLN | 121 | L 4-5 | - | | 10,676 | Dave Roberts | John Denny | John Denny | Dave Roberts | Al Hrabosky | 495 | 540 | -45 |
| 1975-08-13 | vs SLN | 122 | L 3-4 | - | | 11,170 | Joe Niekro | Bob Forsch | Mike Garman | Mike Cosgrove | Bob Gibson | 498 | 544 | -46 |
| 1975-08-14 | vs CHN | 123 | L 3-5 | - | | 7,555 | J.R. Richard | Steve Stone | Steve Stone | J.R. Richard | | 501 | 549 | -48 |
| 1975-08-15 | vs CHN | 124 | W 4-1 | - | | 10,496 | Larry Dierker | Bill Bonham | Larry Dierker | Bill Bonham | | 505 | 550 | -45 |
| 1975-08-16 | vs CHN | 125 | L 2-3 | - | | 7,039 | Dave Roberts | Rick Reuschel | Rick Reuschel | Dave Roberts | | 507 | 553 | -46 |
| 1975-08-17 | vs CHN | 126 | L 7-11 | - | | 8,769 | Jim Crawford | Ray Burris | Ray Burris | Jim Crawford | | 514 | 564 | -50 |
| 1975-08-18 | vs NYN | 127 | W 4-0 | - | | 7,351 | J.R. Richard | Randy Tate | J.R. Richard | Randy Tate | | 518 | 564 | -46 |
| 1975-08-19 | vs NYN | 128 | L 3-6 | - | | 7,843 | Larry Dierker | Jon Matlack | Jon Matlack | Larry Dierker | Jerry Koosman | 521 | 570 | -49 |
| 1975-08-20 | vs NYN | 129 | W 5-4 | - | | 9,667 | Dave Roberts | Hank Webb | Jim Crawford | Rick Baldwin | | 526 | 574 | -48 |
| 1975-08-22 | @ CHN | 130 | L 5-6 | - | | 9,602 | J.R. Richard | Steve Stone | Darold Knowles | Jim Crawford | | 531 | 580 | -49 |
| 1975-08-23 | @ CHN | 131 | W 14-12 | - | | 17,391 | Jim York | Bill Bonham | Jim York | Bill Bonham | Mike Cosgrove | 545 | 592 | -47 |
| 1975-08-24 | @ CHN | 132 | W 8-4 | - | | 19,795 | Larry Dierker | Ray Burris | Larry Dierker | Ray Burris | | 553 | 596 | -43 |
| 1975-08-25 | @ SLN | 133 | L 3-3 | - | | 11,267 | Dave Roberts | Lynn McGlothen | | | | 556 | 599 | -43 |
| 1975-08-26 | @ SLN | 134 | L 9-10 | - | | 0 | J.R. Richard | Ron Reed | Al Hrabosky | Jose Sosa | | 565 | 609 | -44 |
| 1975-08-26 | @ SLN | 135 | L 1-2 | - | | 19,185 | Doug Konieczny | Eric Rasmussen | Eric Rasmussen | Doug Konieczny | | 566 | 611 | -45 |
| 1975-08-27 | @ SLN | 136 | W 5-1 | - | | 13,778 | Jim York | John Denny | Jim York | John Denny | | 571 | 612 | -41 |
| 1975-08-30 | @ PIT | 137 | W 7-4 | - | | 13,473 | Larry Dierker | Jerry Reuss | Larry Dierker | Jerry Reuss | | 578 | 616 | -38 |
| 1975-08-31 | @ PIT | 138 | L 6-9 | - | | 14,507 | Dave Roberts | Larry Demery | Bruce Kison | Jose Sosa | Dave Giusti | 584 | 625 | -41 |
| 1975-09-01 | vs ATL | 139 | W 5-3 | - | | 6,329 | Doug Konieczny | Jamie Easterly | Doug Konieczny | Jamie Easterly | Joe Niekro | 589 | 628 | -39 |
| 1975-09-02 | vs ATL | 140 | L 1-4 | - | | 4,019 | Jim York | Carl Morton | Carl Morton | Jim York | Bruce Dal Canton | 590 | 632 | -42 |
| 1975-09-03 | vs SFN | 141 | L 4-9 | - | | 4,437 | J.R. Richard | Pete Falcone | Pete Falcone | J.R. Richard | | 594 | 641 | -47 |
| 1975-09-04 | vs SFN | 142 | L 1-2 | - | | 4,323 | Larry Dierker | John Montefusco | John Montefusco | Larry Dierker | Randy Moffitt | 595 | 643 | -48 |
| 1975-09-05 | vs SDN | 143 | W 2-1 | - | | 7,088 | Mike Cosgrove | Randy Jones | J.R. Richard | Randy Jones | | 597 | 644 | -47 |
| 1975-09-06 | vs SDN | 144 | L 1-2 | - | | 5,838 | Doug Konieczny | Brent Strom | Brent Strom | Doug Konieczny | | 598 | 646 | -48 |
| 1975-09-07 | vs SDN | 145 | W 3-2 | - | | 5,830 | Dave Roberts | Dan Spillner | Jim York | Danny Frisella | | 601 | 648 | -47 |
| 1975-09-08 | @ ATL | 146 | W 9-6 | - | | 737 | J.R. Richard | Phil Niekro | Jose Sosa | Frank LaCorte | Mike Stanton | 610 | 654 | -44 |
| 1975-09-09 | @ ATL | 147 | L 1-4 | - | | 2,074 | Larry Dierker | Adrian Devine | Adrian Devine | Larry Dierker | Bruce Dal Canton | 611 | 658 | -47 |
| 1975-09-10 | @ SFN | 148 | W 6-3 | - | | 1,016 | Mike Cosgrove | Ed Halicki | Mike Cosgrove | Ed Halicki | | 617 | 661 | -44 |
| 1975-09-11 | @ SFN | 149 | W 4-3 | - | | 1,149 | Jose Sosa | Pete Falcone | Joe Niekro | Randy Moffitt | Jim Crawford | 621 | 664 | -43 |
| 1975-09-12 | @ SDN | 150 | L 0-1 | - | | 8,184 | Paul Siebert | Dan Spillner | Dave Tomlin | Jim York | | 621 | 665 | -44 |
| 1975-09-14 | @ SDN | 151 | W 4-2 | - | | 19,442 | J.R. Richard | Randy Jones | J.R. Richard | Randy Jones | Joe Niekro | 625 | 667 | -42 |
| 1975-09-16 | @ CIN | 152 | W 5-1 | - | | 16,025 | Larry Dierker | Jack Billingham | Larry Dierker | Jack Billingham | | 630 | 668 | -38 |
| 1975-09-17 | @ CIN | 153 | L 1-10 | - | | 13,508 | Mike Stanton | Fred Norman | Fred Norman | Mike Stanton | | 631 | 678 | -47 |
| 1975-09-19 | vs LAN | 154 | W 6-5 | - | | 11,160 | Doug Konieczny | Doug Rau | Dave Roberts | Dave Sells | | 637 | 683 | -46 |
| 1975-09-20 | vs LAN | 155 | L 4-5 | - | | 12,703 | Jose Sosa | Burt Hooton | Charlie Hough | Paul Siebert | | 641 | 688 | -47 |
| 1975-09-21 | vs LAN | 156 | W 4-1 | - | | 8,909 | J.R. Richard | Rick Rhoden | J.R. Richard | Rick Rhoden | | 645 | 689 | -44 |
| 1975-09-22 | vs CIN | 157 | W 5-1 | - | | 6,422 | Joe Niekro | Jack Billingham | Joe Niekro | Jack Billingham | Paul Siebert | 650 | 690 | -40 |
| 1975-09-23 | vs CIN | 158 | L 3-5 | - | | 7,712 | Mike Cosgrove | Fred Norman | Fred Norman | Mike Cosgrove | Rawly Eastwick | 653 | 695 | -42 |
| 1975-09-24 | vs CIN | 159 | L 4-6 | - | | 10,237 | Larry Dierker | Clay Kirby | Clay Kirby | Larry Dierker | Rawly Eastwick | 657 | 701 | -44 |
| 1975-09-26 | @ LAN | 160 | L 2-3 | - | | 17,455 | J.R. Richard | Burt Hooton | Burt Hooton | J.R. Richard | | 659 | 704 | -45 |
| 1975-09-27 | @ LAN | 161 | L 1-5 | - | | 13,529 | Mike Stanton | Andy Messersmith | Andy Messersmith | Mike Stanton | | 660 | 709 | -49 |
| 1975-09-28 | @ LAN | 162 | W 4-2 | - | | 36,507 | Jim York | Rick Rhoden | Jim York | Charlie Hough | Paul Siebert | 664 | 711 | -47 |