| 1975-04-10 | vs BAL | 1 | L 0-10 | 0-1 | 5 | 40,139 | Joe Coleman | Jim Palmer | Jim Palmer | Joe Coleman | | 0 | 10 | -10 |
| 1975-04-11 | @ NYA | 2 | W 5-3 | 1-1 | 5 | 26,212 | Mickey Lolich | Catfish Hunter | Mickey Lolich | Catfish Hunter | John Hiller | 5 | 13 | -8 |
| 1975-04-12 | @ NYA | 3 | W 7-2 | 2-1 | 3 | 12,215 | Vern Ruhle | Pat Dobson | Vern Ruhle | Pat Dobson | | 12 | 15 | -3 |
| 1975-04-13 | @ NYA | 4 | L 0-6 | 3-2 | 2 | 0 | Tom Walker | Doc Medich | Doc Medich | Tom Walker | | 12 | 21 | -9 |
| 1975-04-13 | @ NYA | 5 | W 5-2 | 3-2 | 2 | 28,051 | Lerrin LaGrow | Rudy May | Lerrin LaGrow | Rudy May | | 17 | 23 | -6 |
| 1975-04-18 | vs NYA | 6 | L 3-11 | 3-3 | 4 | 9,047 | Joe Coleman | Doc Medich | Doc Medich | Joe Coleman | | 20 | 34 | -14 |
| 1975-04-19 | vs NYA | 7 | W 8-3 | 4-3 | 4 | 8,396 | Mickey Lolich | Catfish Hunter | Mickey Lolich | Catfish Hunter | | 28 | 37 | -9 |
| 1975-04-20 | vs NYA | 8 | L 1-7 | 4-4 | 4 | 9,610 | Vern Ruhle | Rudy May | Rudy May | Vern Ruhle | | 29 | 44 | -15 |
| 1975-04-22 | vs CLE | 9 | W 6-2 | 5-4 | 2 | 5,692 | Lerrin LaGrow | Gaylord Perry | Lerrin LaGrow | Gaylord Perry | | 35 | 46 | -11 |
| 1975-04-23 | vs CLE | 10 | L 3-4 | 5-5 | 4 | 5,470 | Joe Coleman | Jim Perry | Jim Perry | Joe Coleman | Tom Buskey | 38 | 50 | -12 |
| 1975-04-25 | vs BOS | 11 | W 1-0 | 6-5 | 2 | 10,109 | Mickey Lolich | Luis Tiant | Mickey Lolich | Luis Tiant | | 39 | 50 | -11 |
| 1975-04-26 | vs BOS | 12 | W 3-2 | 7-5 | 1 | 9,594 | Vern Ruhle | Bill Lee | John Hiller | Bill Lee | | 42 | 52 | -10 |
| 1975-04-27 | vs BOS | 13 | W 5-4 | 8-5 | 1 | 17,414 | Lerrin LaGrow | Rick Wise | Lerrin LaGrow | Rick Wise | John Hiller | 47 | 56 | -9 |
| 1975-04-28 | @ BAL | 14 | W 5-3 | 9-5 | 1 | 3,784 | Joe Coleman | Mike Cuellar | Joe Coleman | Mike Cuellar | John Hiller | 52 | 59 | -7 |
| 1975-04-29 | @ BAL | 15 | W 4-2 | 10-5 | 1 | 4,668 | Mickey Lolich | Ross Grimsley | Tom Walker | Ross Grimsley | | 56 | 61 | -5 |
| 1975-04-30 | @ MIL | 16 | L 2-6 | 10-6 | 1 | 6,075 | Dave Lemanczyk | Jim Slaton | Jim Slaton | Dave Lemanczyk | Eduardo Rodriguez | 58 | 67 | -9 |
| 1975-05-01 | @ MIL | 17 | L 3-17 | 10-7 | 1 | 8,395 | Vern Ruhle | Pete Broberg | Pete Broberg | Ray Bare | Jim Colborn | 61 | 84 | -23 |
| 1975-05-03 | @ BOS | 18 | L 2-12 | 10-8 | 2 | 13,153 | Lerrin LaGrow | Rick Wise | Rick Wise | Lerrin LaGrow | | 63 | 96 | -33 |
| 1975-05-06 | vs MIL | 19 | W 4-2 | 11-8 | 2 | 11,035 | Joe Coleman | Pete Broberg | Joe Coleman | Pete Broberg | | 67 | 98 | -31 |
| 1975-05-07 | vs MIL | 20 | L 5-7 | 11-9 | 3 | 13,610 | Mickey Lolich | Bill Champion | Eduardo Rodriguez | Mickey Lolich | | 72 | 105 | -33 |
| 1975-05-08 | vs MIL | 21 | W 6-4 | 12-9 | 3 | 10,220 | Vern Ruhle | Jim Slaton | Ray Bare | Jim Colborn | John Hiller | 78 | 109 | -31 |
| 1975-05-09 | vs TEX | 22 | L 1-3 | 12-10 | 3 | 23,370 | Lerrin LaGrow | Jackie Brown | Jackie Brown | Lerrin LaGrow | | 79 | 112 | -33 |
| 1975-05-10 | vs TEX | 23 | L 2-5 | 12-11 | 3 | 15,283 | Joe Coleman | Bill Hands | Bill Hands | Joe Coleman | | 81 | 117 | -36 |
| 1975-05-11 | vs TEX | 24 | L 7-11 | 12-12 | 3 | 11,854 | Mickey Lolich | Fergie Jenkins | Fergie Jenkins | Mickey Lolich | Steve Foucault | 88 | 128 | -40 |
| 1975-05-12 | vs KCA | 25 | W 5-0 | 13-12 | 3 | 7,002 | Vern Ruhle | Dennis Leonard | Vern Ruhle | Dennis Leonard | | 93 | 128 | -35 |
| 1975-05-13 | vs KCA | 26 | L 7-8 | 13-13 | 3 | 8,370 | Lerrin LaGrow | Al Fitzmorris | Al Fitzmorris | Lerrin LaGrow | | 100 | 136 | -36 |
| 1975-05-14 | vs KCA | 27 | L 1-4 | 13-14 | 4 | 8,009 | Joe Coleman | Nelson Briles | Nelson Briles | Joe Coleman | | 101 | 140 | -39 |
| 1975-05-16 | @ TEX | 28 | L 3-10 | 13-15 | 4 | 15,755 | Mickey Lolich | Bill Hands | Bill Hands | Mickey Lolich | | 104 | 150 | -46 |
| 1975-05-17 | @ TEX | 29 | W 6-4 | 14-15 | 3 | 21,896 | Vern Ruhle | Jackie Brown | Vern Ruhle | Jackie Brown | John Hiller | 110 | 154 | -44 |
| 1975-05-18 | @ TEX | 30 | L 6-7 | 14-16 | 3 | 12,682 | Lerrin LaGrow | Fergie Jenkins | Stan Thomas | Dave Lemanczyk | | 116 | 161 | -45 |
| 1975-05-19 | @ MIN | 31 | W 6-3 | 15-16 | 3 | 3,399 | Joe Coleman | Mike Pazik | Joe Coleman | Mike Pazik | John Hiller | 122 | 164 | -42 |
| 1975-05-20 | @ MIN | 32 | W 5-3 | 16-16 | 3 | 4,144 | Mickey Lolich | Dave Goltz | Mickey Lolich | Dave Goltz | | 127 | 167 | -40 |
| 1975-05-21 | @ MIN | 33 | L 5-6 | 16-17 | 3 | 4,999 | Vern Ruhle | Vic Albury | Ray Corbin | John Hiller | | 132 | 173 | -41 |
| 1975-05-23 | @ CHA | 34 | L 1-6 | 16-18 | 3 | 8,789 | Lerrin LaGrow | Wilbur Wood | Terry Forster | Lerrin LaGrow | | 133 | 179 | -46 |
| 1975-05-24 | @ CHA | 35 | L 8-10 | 16-19 | 3 | 29,683 | Joe Coleman | Stan Bahnsen | Stan Bahnsen | Joe Coleman | Bill Gogolewski | 141 | 189 | -48 |
| 1975-05-25 | @ CHA | 36 | W 4-1 | 17-19 | 3 | 30,947 | Mickey Lolich | Claude Osteen | Mickey Lolich | Claude Osteen | | 145 | 190 | -45 |
| 1975-05-26 | vs MIN | 37 | W 6-2 | 18-19 | 3 | 15,361 | Vern Ruhle | Bill Campbell | Vern Ruhle | Bill Campbell | | 151 | 192 | -41 |
| 1975-05-27 | vs MIN | 38 | L 5-6 | 18-20 | 3 | 8,764 | Lerrin LaGrow | Bert Blyleven | Vic Albury | John Hiller | | 156 | 198 | -42 |
| 1975-05-28 | vs MIN | 39 | L 2-5 | 18-21 | 3 | 9,675 | Joe Coleman | Jim Hughes | Jim Hughes | Joe Coleman | | 158 | 203 | -45 |
| 1975-05-31 | vs CHA | 40 | W 2-0 | 19-21 | 3 | 13,152 | Vern Ruhle | Jim Kaat | Vern Ruhle | Jim Kaat | | 160 | 203 | -43 |
| 1975-06-01 | vs CHA | 41 | W 5-1 | 20-22 | 4 | 0 | Mickey Lolich | Wilbur Wood | Mickey Lolich | Wilbur Wood | | 165 | 204 | -39 |
| 1975-06-01 | vs CHA | 42 | L 2-3 | 20-22 | 4 | 26,749 | Lerrin LaGrow | Claude Osteen | Rich Gossage | Tom Walker | | 167 | 207 | -40 |
| 1975-06-03 | @ CAL | 43 | W 8-5 | 21-22 | 4 | 7,412 | Joe Coleman | Frank Tanana | John Hiller | Frank Tanana | | 175 | 212 | -37 |
| 1975-06-04 | @ CAL | 44 | L 1-2 | 21-23 | 4 | 8,411 | Ray Bare | Ed Figueroa | Ed Figueroa | Ray Bare | | 176 | 214 | -38 |
| 1975-06-05 | @ CAL | 45 | L 3-8 | 21-24 | 4 | 7,357 | Vern Ruhle | Bill Singer | Bill Singer | Vern Ruhle | | 179 | 222 | -43 |
| 1975-06-06 | @ OAK | 46 | W 11-2 | 22-24 | 4 | 6,536 | Mickey Lolich | Dick Bosman | Mickey Lolich | Dick Bosman | John Hiller | 190 | 224 | -34 |
| 1975-06-07 | @ OAK | 47 | W 3-0 | 23-24 | 3 | 34,953 | Lerrin LaGrow | Vida Blue | Lerrin LaGrow | Vida Blue | | 193 | 224 | -31 |
| 1975-06-08 | @ OAK | 48 | L 0-4 | 23-25 | 4 | 9,780 | Joe Coleman | Ken Holtzman | Ken Holtzman | Joe Coleman | | 193 | 228 | -35 |
| 1975-06-09 | @ KCA | 49 | L 2-5 | 23-26 | 4 | 10,026 | Tom Walker | Al Fitzmorris | Lindy McDaniel | Tom Walker | | 195 | 233 | -38 |
| 1975-06-10 | @ KCA | 50 | L 3-4 | 23-27 | 4 | 8,759 | Vern Ruhle | Marty Pattin | Marty Pattin | Vern Ruhle | Lindy McDaniel | 198 | 237 | -39 |
| 1975-06-11 | vs CAL | 51 | L 7-14 | 24-28 | 4 | 0 | Mickey Lolich | Frank Tanana | Frank Tanana | Mickey Lolich | | 205 | 251 | -46 |
| 1975-06-11 | vs CAL | 52 | W 5-3 | 24-28 | 4 | 22,835 | Ray Bare | Andy Hassler | Ray Bare | Andy Hassler | John Hiller | 210 | 254 | -44 |
| 1975-06-12 | vs CAL | 53 | L 1-7 | 24-29 | 4 | 14,490 | Lerrin LaGrow | Ed Figueroa | Ed Figueroa | Lerrin LaGrow | | 211 | 261 | -50 |
| 1975-06-13 | vs OAK | 54 | L 5-7 | 24-30 | 4 | 29,567 | Joe Coleman | Ken Holtzman | Paul Lindblad | Joe Coleman | Rollie Fingers | 216 | 268 | -52 |
| 1975-06-14 | vs OAK | 55 | W 3-2 | 25-30 | 4 | 21,121 | Tom Walker | Sonny Siebert | Tom Walker | Sonny Siebert | John Hiller | 219 | 270 | -51 |
| 1975-06-16 | vs BOS | 56 | L 2-6 | 25-31 | 5 | 17,074 | Mickey Lolich | Jim Burton | Reggie Cleveland | Tom Walker | | 221 | 276 | -55 |
| 1975-06-17 | vs BOS | 57 | L 6-7 | 25-32 | 5 | 9,803 | Lerrin LaGrow | Rick Wise | Rick Wise | Lerrin LaGrow | Dick Drago | 227 | 283 | -56 |
| 1975-06-18 | vs BOS | 58 | L 1-15 | 25-33 | 5 | 13,029 | Joe Coleman | Luis Tiant | Luis Tiant | Joe Coleman | | 228 | 298 | -70 |
| 1975-06-19 | vs NYA | 59 | L 2-9 | 25-34 | 5 | 14,271 | Ray Bare | Catfish Hunter | Catfish Hunter | Ray Bare | | 230 | 307 | -77 |
| 1975-06-20 | vs NYA | 60 | W 10-9 | 26-34 | 5 | 23,347 | Vern Ruhle | Rudy May | Vern Ruhle | Rudy May | | 240 | 316 | -76 |
| 1975-06-21 | vs NYA | 61 | L 1-4 | 26-35 | 5 | 19,780 | Mickey Lolich | Pat Dobson | Pat Dobson | Mickey Lolich | | 241 | 320 | -79 |
| 1975-06-22 | vs NYA | 62 | L 3-5 | 26-36 | 5 | 31,077 | Tom Walker | Larry Gura | Larry Gura | Tom Walker | Dick Tidrow | 244 | 325 | -81 |
| 1975-06-23 | @ MIL | 63 | L 4-8 | 26-37 | 5 | 10,945 | Joe Coleman | Bill Castro | Tom Hausman | Joe Coleman | | 248 | 333 | -85 |
| 1975-06-24 | @ MIL | 64 | L 0-5 | 26-39 | 6 | 0 | Ray Bare | Jim Slaton | Jim Slaton | Ray Bare | | 248 | 338 | -90 |
| 1975-06-24 | @ MIL | 65 | L 2-4 | 26-39 | 6 | 21,199 | Lerrin LaGrow | Bill Travers | Bill Travers | Lerrin LaGrow | | 250 | 342 | -92 |
| 1975-06-25 | @ MIL | 66 | L 6-7 | 26-40 | 6 | 12,681 | Vern Ruhle | Pete Broberg | Pete Broberg | Vern Ruhle | Ed Sprague | 256 | 349 | -93 |
| 1975-06-26 | @ BAL | 67 | W 6-5 | 27-40 | 6 | 7,053 | Mickey Lolich | Mike Cuellar | Mickey Lolich | Doyle Alexander | | 262 | 354 | -92 |
| 1975-06-27 | @ BAL | 68 | L 2-3 | 27-41 | 6 | 8,748 | Tom Walker | Ross Grimsley | Ross Grimsley | John Hiller | | 264 | 357 | -93 |
| 1975-06-28 | @ BAL | 69 | L 4-7 | 27-42 | 6 | 20,700 | Joe Coleman | Mike Torrez | Mike Torrez | Joe Coleman | Grant Jackson | 268 | 364 | -96 |
| 1975-06-29 | @ BAL | 70 | L 1-2 | 27-43 | 6 | 12,908 | Ray Bare | Mike Cuellar | Mike Cuellar | Ray Bare | | 269 | 366 | -97 |
| 1975-06-30 | @ CLE | 71 | L 1-4 | 27-45 | 6 | 0 | Vern Ruhle | Roric Harrison | Roric Harrison | Vern Ruhle | | 270 | 370 | -100 |
| 1975-06-30 | @ CLE | 72 | L 2-3 | 27-45 | 6 | 26,114 | Lerrin LaGrow | Eric Raich | Eric Raich | Lerrin LaGrow | | 272 | 373 | -101 |
| 1975-07-01 | @ CLE | 73 | W 6-2 | 28-45 | 6 | 7,539 | Mickey Lolich | Jim Bibby | Mickey Lolich | Jim Bibby | | 278 | 375 | -97 |
| 1975-07-02 | vs BAL | 74 | L 5-13 | 28-46 | 6 | 10,671 | Tom Walker | Mike Torrez | Mike Torrez | Tom Walker | | 283 | 388 | -105 |
| 1975-07-03 | vs BAL | 75 | W 9-5 | 29-46 | 6 | 10,940 | Joe Coleman | Mike Cuellar | Joe Coleman | Wayne Garland | | 292 | 393 | -101 |
| 1975-07-04 | vs MIL | 76 | W 8-2 | 30-46 | 6 | 14,259 | Ray Bare | Bill Travers | Ray Bare | Bill Travers | | 300 | 395 | -95 |
| 1975-07-05 | vs MIL | 77 | W 3-2 | 31-46 | 6 | 14,092 | Vern Ruhle | Jim Colborn | Vern Ruhle | Jim Colborn | | 303 | 397 | -94 |
| 1975-07-06 | vs MIL | 78 | W 7-5 | 33-46 | 6 | 0 | Mickey Lolich | Tom Hausman | Mickey Lolich | Tom Hausman | John Hiller | 310 | 402 | -92 |
| 1975-07-06 | vs MIL | 79 | W 11-2 | 33-46 | 6 | 24,019 | Lerrin LaGrow | Pete Broberg | Lerrin LaGrow | Pete Broberg | | 321 | 404 | -83 |
| 1975-07-07 | vs CHA | 80 | W 2-1 | 34-46 | 6 | 15,377 | Tom Walker | Jim Kaat | Tom Walker | Jim Kaat | | 323 | 405 | -82 |
| 1975-07-08 | vs CHA | 81 | W 3-0 | 35-46 | 6 | 13,268 | Joe Coleman | Wilbur Wood | Joe Coleman | Wilbur Wood | John Hiller | 326 | 405 | -79 |
| 1975-07-09 | vs CHA | 82 | W 6-2 | 36-46 | 6 | 16,155 | Ray Bare | Jesse Jefferson | Ray Bare | Jesse Jefferson | | 332 | 407 | -75 |
| 1975-07-10 | @ KCA | 83 | W 3-2 | 37-46 | 6 | 10,968 | Vern Ruhle | Steve Busby | Vern Ruhle | Steve Busby | Bob Reynolds | 335 | 409 | -74 |
| 1975-07-11 | @ KCA | 84 | L 2-5 | 37-47 | 6 | 14,391 | Mickey Lolich | Marty Pattin | Marty Pattin | Mickey Lolich | | 337 | 414 | -77 |
| 1975-07-12 | @ KCA | 85 | W 2-0 | 38-47 | 6 | 17,944 | Lerrin LaGrow | Al Fitzmorris | Lerrin LaGrow | Al Fitzmorris | | 339 | 414 | -75 |
| 1975-07-13 | @ KCA | 86 | W 8-4 | 39-47 | 6 | 19,856 | Joe Coleman | Dennis Leonard | Joe Coleman | Dennis Leonard | John Hiller | 347 | 418 | -71 |
| 1975-07-17 | @ CHA | 87 | L 0-4 | 40-48 | 6 | 0 | Mickey Lolich | Wilbur Wood | Wilbur Wood | Mickey Lolich | | 347 | 422 | -75 |
| 1975-07-17 | @ CHA | 88 | W 9-1 | 40-48 | 6 | 13,161 | Lerrin LaGrow | Claude Osteen | Lerrin LaGrow | Claude Osteen | | 356 | 423 | -67 |
| 1975-07-18 | @ CHA | 89 | L 0-4 | 40-49 | 6 | 11,701 | Vern Ruhle | Jim Kaat | Jim Kaat | Vern Ruhle | | 356 | 427 | -71 |
| 1975-07-19 | vs KCA | 90 | W 10-8 | 41-49 | 5 | 22,151 | Joe Coleman | Marty Pattin | Joe Coleman | Marty Pattin | John Hiller | 366 | 435 | -69 |
| 1975-07-20 | vs KCA | 91 | W 7-3 | 42-49 | 5 | 20,142 | Ray Bare | Nelson Briles | Ray Bare | Nelson Briles | | 373 | 438 | -65 |
| 1975-07-21 | vs KCA | 92 | L 2-3 | 42-50 | 6 | 19,090 | Mickey Lolich | Dennis Leonard | Dennis Leonard | Mickey Lolich | Steve Mingori | 375 | 441 | -66 |
| 1975-07-22 | vs OAK | 93 | L 0-11 | 42-52 | 6 | 0 | Tom Walker | Glenn Abbott | Glenn Abbott | Tom Walker | | 375 | 452 | -77 |
| 1975-07-22 | vs OAK | 94 | L 4-16 | 42-52 | 6 | 29,089 | Lerrin LaGrow | Stan Bahnsen | Stan Bahnsen | Lerrin LaGrow | | 379 | 468 | -89 |
| 1975-07-23 | vs OAK | 95 | L 0-3 | 42-53 | 6 | 20,251 | Vern Ruhle | Vida Blue | Vida Blue | Vern Ruhle | | 379 | 471 | -92 |
| 1975-07-24 | vs OAK | 96 | W 5-2 | 43-53 | 5 | 14,255 | Joe Coleman | Jim Perry | Joe Coleman | Jim Perry | John Hiller | 384 | 473 | -89 |
| 1975-07-25 | vs CLE | 97 | W 4-3 | 44-53 | 5 | 25,627 | Ray Bare | Don Hood | Ray Bare | Don Hood | Bob Reynolds | 388 | 476 | -88 |
| 1975-07-26 | vs CLE | 98 | L 0-6 | 44-54 | 5 | 0 | Mickey Lolich | Dennis Eckersley | Dennis Eckersley | Mickey Lolich | | 388 | 482 | -94 |
| 1975-07-27 | vs CLE | 99 | W 8-7 | 45-55 | 5 | 0 | Tom Walker | Eric Raich | Fernando Arroyo | Dave LaRoche | Bob Reynolds | 396 | 489 | -93 |
| 1975-07-27 | vs CLE | 100 | L 2-7 | 45-55 | 5 | 30,850 | Lerrin LaGrow | Fritz Peterson | Fritz Peterson | Lerrin LaGrow | | 398 | 496 | -98 |
| 1975-07-28 | @ NYA | 101 | W 3-0 | 46-55 | 5 | 11,244 | Vern Ruhle | Larry Gura | Vern Ruhle | Larry Gura | | 401 | 496 | -95 |
| 1975-07-29 | @ NYA | 102 | L 2-4 | 46-56 | 5 | 13,410 | Joe Coleman | Doc Medich | Doc Medich | Joe Coleman | Tippy Martinez | 403 | 500 | -97 |
| 1975-07-30 | @ NYA | 103 | L 1-2 | 46-57 | 6 | 12,591 | Mickey Lolich | Rudy May | Rudy May | Mickey Lolich | | 404 | 502 | -98 |
| 1975-07-31 | @ BOS | 104 | L 2-3 | 46-59 | 6 | 0 | Ray Bare | Bill Lee | Bill Lee | Bob Reynolds | | 406 | 505 | -99 |
| 1975-07-31 | @ BOS | 105 | L 1-6 | 46-59 | 6 | 31,317 | Dave Lemanczyk | Roger Moret | Roger Moret | Dave Lemanczyk | | 407 | 511 | -104 |
| 1975-08-01 | @ BOS | 106 | L 7-8 | 46-60 | 6 | 26,537 | Lerrin LaGrow | Luis Tiant | Jim Willoughby | Gene Pentz | | 414 | 519 | -105 |
| 1975-08-02 | @ BOS | 107 | L 2-7 | 46-61 | 6 | 27,188 | Vern Ruhle | Rick Wise | Rick Wise | Vern Ruhle | | 416 | 526 | -110 |
| 1975-08-03 | @ BOS | 108 | L 4-6 | 46-62 | 6 | 23,575 | Joe Coleman | Reggie Cleveland | Reggie Cleveland | Tom Walker | Jim Willoughby | 420 | 532 | -112 |
| 1975-08-04 | @ CLE | 109 | L 4-6 | 46-63 | 6 | 11,240 | Mickey Lolich | Dennis Eckersley | Dennis Eckersley | Mickey Lolich | Jackie Brown | 424 | 538 | -114 |
| 1975-08-05 | @ CLE | 110 | L 4-8 | 46-64 | 6 | 5,442 | Ray Bare | Eric Raich | Eric Raich | Ray Bare | Rick Waits | 428 | 546 | -118 |
| 1975-08-06 | vs BAL | 111 | L 2-4 | 46-66 | 6 | 0 | Lerrin LaGrow | Mike Torrez | Mike Torrez | Lerrin LaGrow | Wayne Garland | 430 | 550 | -120 |
| 1975-08-06 | vs BAL | 112 | L 2-8 | 46-66 | 6 | 15,500 | Dave Lemanczyk | Ross Grimsley | Ross Grimsley | Dave Lemanczyk | Dyar Miller | 432 | 558 | -126 |
| 1975-08-07 | vs BAL | 113 | L 6-7 | 46-67 | 6 | 11,321 | Vern Ruhle | Mike Cuellar | Dyar Miller | Bob Reynolds | | 438 | 565 | -127 |
| 1975-08-08 | vs MIN | 114 | L 1-3 | 46-68 | 6 | 18,259 | Joe Coleman | Jim Hughes | Jim Hughes | Joe Coleman | | 439 | 568 | -129 |
| 1975-08-09 | vs MIN | 115 | L 0-1 | 46-69 | 6 | 18,028 | Mickey Lolich | Dave Goltz | Dave Goltz | Mickey Lolich | | 439 | 569 | -130 |
| 1975-08-10 | vs MIN | 116 | L 0-4 | 46-70 | 6 | 11,851 | Ray Bare | Bert Blyleven | Bert Blyleven | Ray Bare | | 439 | 573 | -134 |
| 1975-08-11 | vs TEX | 117 | L 0-7 | 46-71 | 6 | 14,694 | Lerrin LaGrow | Gaylord Perry | Gaylord Perry | Lerrin LaGrow | | 439 | 580 | -141 |
| 1975-08-12 | vs TEX | 118 | L 3-4 | 46-72 | 6 | 10,563 | Vern Ruhle | Stan Perzanowski | Stan Perzanowski | Vern Ruhle | Steve Foucault | 442 | 584 | -142 |
| 1975-08-13 | vs TEX | 119 | L 5-6 | 46-73 | 6 | 10,263 | Joe Coleman | Fergie Jenkins | Steve Foucault | Gene Pentz | | 447 | 590 | -143 |
| 1975-08-15 | @ CAL | 120 | L 0-8 | 46-74 | 6 | 8,885 | Mickey Lolich | Frank Tanana | Frank Tanana | Mickey Lolich | | 447 | 598 | -151 |
| 1975-08-16 | @ CAL | 121 | W 8-0 | 47-74 | 6 | 31,569 | Ray Bare | Chuck Hockenbery | Ray Bare | Chuck Hockenbery | | 455 | 598 | -143 |
| 1975-08-17 | @ CAL | 122 | W 7-0 | 48-74 | 6 | 8,358 | Vern Ruhle | Ed Figueroa | Vern Ruhle | Ed Figueroa | | 462 | 598 | -136 |
| 1975-08-18 | @ OAK | 123 | W 5-3 | 49-74 | 6 | 24,488 | Joe Coleman | Vida Blue | Joe Coleman | Vida Blue | | 467 | 601 | -134 |
| 1975-08-19 | @ OAK | 124 | W 3-1 | 50-74 | 6 | 5,016 | Mickey Lolich | Dick Bosman | Mickey Lolich | Dick Bosman | | 470 | 602 | -132 |
| 1975-08-20 | @ OAK | 125 | L 1-2 | 50-75 | 6 | 6,255 | Ray Bare | Sonny Siebert | Sonny Siebert | Ray Bare | Jim Todd | 471 | 604 | -133 |
| 1975-08-22 | @ MIN | 126 | L 4-8 | 50-76 | 6 | 8,101 | Vern Ruhle | Dave Goltz | Dave Goltz | Vern Ruhle | Bill Campbell | 475 | 612 | -137 |
| 1975-08-23 | @ MIN | 127 | W 6-5 | 51-76 | 6 | 9,052 | Lerrin LaGrow | Bert Blyleven | Dave Lemanczyk | Tom Burgmeier | | 481 | 617 | -136 |
| 1975-08-24 | @ MIN | 128 | L 1-3 | 51-77 | 6 | 7,570 | Mickey Lolich | Jim Hughes | Jim Hughes | Mickey Lolich | | 482 | 620 | -138 |
| 1975-08-25 | @ TEX | 129 | L 0-1 | 51-78 | 6 | 5,458 | Ray Bare | Jim Umbarger | Jim Umbarger | Ray Bare | | 482 | 621 | -139 |
| 1975-08-26 | @ TEX | 130 | L 2-3 | 51-79 | 6 | 7,308 | Vern Ruhle | Gaylord Perry | Gaylord Perry | Gene Pentz | | 484 | 624 | -140 |
| 1975-08-27 | @ TEX | 131 | L 2-8 | 51-80 | 6 | 5,910 | Lerrin LaGrow | Fergie Jenkins | Fergie Jenkins | Lerrin LaGrow | | 486 | 632 | -146 |
| 1975-08-29 | vs CAL | 132 | L 1-8 | 51-81 | 6 | 10,451 | Mickey Lolich | Frank Tanana | Frank Tanana | Mickey Lolich | | 487 | 640 | -153 |
| 1975-08-30 | vs CAL | 133 | W 9-2 | 52-81 | 6 | 7,570 | Ray Bare | Chuck Hockenbery | Ray Bare | Chuck Hockenbery | | 496 | 642 | -146 |
| 1975-09-01 | vs MIL | 134 | W 5-4 | 53-81 | 6 | 7,584 | Vern Ruhle | Bill Travers | Dave Lemanczyk | Rick Austin | | 501 | 646 | -145 |
| 1975-09-02 | vs MIL | 135 | L 5-6 | 53-82 | 6 | 6,263 | Joe Coleman | Jim Colborn | Jim Colborn | Joe Coleman | Eduardo Rodriguez | 506 | 652 | -146 |
| 1975-09-03 | vs NYA | 136 | L 0-8 | 53-83 | 6 | 6,581 | Mickey Lolich | Catfish Hunter | Catfish Hunter | Mickey Lolich | | 506 | 660 | -154 |
| 1975-09-04 | vs NYA | 137 | L 1-8 | 53-84 | 6 | 6,341 | Ray Bare | Rudy May | Rudy May | Ray Bare | | 507 | 668 | -161 |
| 1975-09-05 | @ CLE | 138 | W 11-2 | 54-84 | 6 | 4,108 | Vern Ruhle | Rick Waits | Vern Ruhle | Rick Waits | | 518 | 670 | -152 |
| 1975-09-06 | @ CLE | 139 | L 2-4 | 54-85 | 6 | 7,851 | Dave Lemanczyk | Dennis Eckersley | Dennis Eckersley | Dave Lemanczyk | Dave LaRoche | 520 | 674 | -154 |
| 1975-09-07 | @ CLE | 140 | L 2-7 | 54-87 | 6 | 0 | Joe Coleman | Jim Bibby | Jim Bibby | Joe Coleman | Tom Buskey | 522 | 681 | -159 |
| 1975-09-07 | @ CLE | 141 | L 0-9 | 54-87 | 6 | 17,928 | Lerrin LaGrow | Fritz Peterson | Fritz Peterson | Lerrin LaGrow | | 522 | 690 | -168 |
| 1975-09-08 | @ NYA | 142 | L 0-3 | 54-88 | 6 | 6,944 | Mickey Lolich | Rudy May | Rudy May | Mickey Lolich | | 522 | 693 | -171 |
| 1975-09-09 | @ NYA | 143 | L 6-9 | 54-89 | 6 | 7,240 | Ray Bare | Doc Medich | Doc Medich | Ray Bare | Tippy Martinez | 528 | 702 | -174 |
| 1975-09-10 | @ BOS | 144 | L 4-7 | 55-90 | 6 | 0 | Vern Ruhle | Roger Moret | Roger Moret | Vern Ruhle | Dick Drago | 532 | 709 | -177 |
| 1975-09-10 | @ BOS | 145 | W 5-3 | 55-90 | 6 | 20,189 | Fernando Arroyo | Dick Pole | Fernando Arroyo | Jim Willoughby | | 537 | 712 | -175 |
| 1975-09-11 | @ BOS | 146 | L 1-3 | 55-91 | 6 | 9,508 | Dave Lemanczyk | Luis Tiant | Luis Tiant | Dave Lemanczyk | | 538 | 715 | -177 |
| 1975-09-12 | vs BAL | 147 | L 4-6 | 55-92 | 6 | 7,014 | Joe Coleman | Mike Torrez | Mike Torrez | Joe Coleman | Dyar Miller | 542 | 721 | -179 |
| 1975-09-13 | vs BAL | 148 | L 0-8 | 55-93 | 6 | 10,266 | Mickey Lolich | Doyle Alexander | Doyle Alexander | Mickey Lolich | | 542 | 729 | -187 |
| 1975-09-14 | vs BAL | 149 | L 3-9 | 55-94 | 6 | 11,151 | Ray Bare | Mike Cuellar | Paul Mitchell | Ray Bare | | 545 | 738 | -193 |
| 1975-09-16 | vs CLE | 150 | L 2-9 | 55-95 | 6 | 4,472 | Fernando Arroyo | Dennis Eckersley | Dennis Eckersley | Fernando Arroyo | | 547 | 747 | -200 |
| 1975-09-17 | vs CLE | 151 | W 4-0 | 56-95 | 6 | 4,609 | Joe Coleman | Roric Harrison | Joe Coleman | Roric Harrison | | 551 | 747 | -196 |
| 1975-09-18 | vs CLE | 152 | L 1-2 | 56-96 | 6 | 4,078 | Dave Lemanczyk | Jim Bibby | Jim Bibby | Dave Lemanczyk | Tom Buskey | 552 | 749 | -197 |
| 1975-09-19 | vs BOS | 153 | L 5-7 | 56-97 | 6 | 7,780 | Ray Bare | Bill Lee | Dick Pole | Ed Glynn | Dick Drago | 557 | 756 | -199 |
| 1975-09-20 | vs BOS | 154 | W 5-1 | 57-97 | 6 | 10,186 | Mickey Lolich | Luis Tiant | Mickey Lolich | Luis Tiant | | 562 | 757 | -195 |
| 1975-09-21 | vs BOS | 155 | L 5-6 | 57-98 | 6 | 9,059 | Vern Ruhle | Roger Moret | Dick Drago | Gene Pentz | | 567 | 763 | -196 |
| 1975-09-24 | @ BAL | 156 | L 1-8 | 57-99 | 6 | 4,626 | Joe Coleman | Jim Palmer | Jim Palmer | Joe Coleman | | 568 | 771 | -203 |
| 1975-09-26 | @ MIL | 157 | L 0-3 | 57-100 | 6 | 4,908 | Ray Bare | Pete Broberg | Pete Broberg | Ray Bare | | 568 | 774 | -206 |
| 1975-09-27 | @ MIL | 158 | L 2-5 | 57-101 | 6 | 7,567 | Vern Ruhle | Jerry Augustine | Jerry Augustine | Vern Ruhle | | 570 | 779 | -209 |
| 1975-09-28 | @ MIL | 159 | L 0-7 | 57-102 | 6 | 8,768 | Ed Glynn | Larry Anderson | Larry Anderson | Ed Glynn | | 570 | 786 | -216 |