| 1974-04-04 | vs ATL | 1 | W 7-6 | 1-0 | 1 | 52,154 | Jack Billingham | Carl Morton | Clay Carroll | Buzz Capra | | 7 | 6 | 1 |
| 1974-04-06 | vs ATL | 2 | W 7-5 | 2-0 | 1 | 17,703 | Don Gullett | Roric Harrison | Pedro Borbon | Roric Harrison | | 14 | 11 | 3 |
| 1974-04-07 | vs ATL | 3 | L 3-5 | 2-1 | 3 | 35,588 | Clay Kirby | Phil Niekro | Phil Niekro | Clay Kirby | | 17 | 16 | 1 |
| 1974-04-08 | @ SFN | 4 | L 3-4 | 2-2 | 4 | 4,729 | Roger Nelson | John D'Acquisto | John D'Acquisto | Roger Nelson | Randy Moffitt | 20 | 20 | 0 |
| 1974-04-09 | @ SFN | 5 | W 6-3 | 3-2 | 3 | 8,426 | Jack Billingham | Tom Bradley | Jack Billingham | Tom Bradley | Pedro Borbon | 26 | 23 | 3 |
| 1974-04-10 | @ SFN | 6 | L 3-4 | 3-3 | 3 | 8,456 | Don Gullett | Mike Caldwell | Mike Caldwell | Don Gullett | | 29 | 27 | 2 |
| 1974-04-12 | @ ATL | 7 | W 14-2 | 4-3 | 3 | 8,112 | Clay Kirby | Ron Reed | Clay Kirby | Ron Reed | Roger Nelson | 43 | 29 | 14 |
| 1974-04-13 | @ ATL | 8 | L 3-10 | 4-4 | 3 | 11,238 | Jack Billingham | Carl Morton | Carl Morton | Jack Billingham | | 46 | 39 | 7 |
| 1974-04-16 | vs LAN | 9 | L 3-5 | 4-5 | 5 | 12,625 | Clay Kirby | Andy Messersmith | Jim Brewer | Fred Norman | | 49 | 44 | 5 |
| 1974-04-17 | vs LAN | 10 | L 1-14 | 4-6 | 5 | 12,497 | Roger Nelson | Doug Rau | Doug Rau | Roger Nelson | | 50 | 58 | -8 |
| 1974-04-19 | vs SDN | 11 | W 8-4 | 5-6 | 5 | 33,069 | Jack Billingham | Randy Jones | Jack Billingham | Randy Jones | | 58 | 62 | -4 |
| 1974-04-20 | vs SDN | 12 | W 11-0 | 6-6 | 5 | 12,471 | Don Gullett | Steve Arlin | Don Gullett | Steve Arlin | | 69 | 62 | 7 |
| 1974-04-21 | vs SDN | 13 | W 10-1 | 7-7 | 5 | 0 | Fred Norman | Jim McAndrew | Fred Norman | Jim McAndrew | | 79 | 63 | 16 |
| 1974-04-21 | vs SDN | 14 | L 2-7 | 7-7 | 5 | 25,727 | Clay Kirby | Bill Greif | Bill Greif | Clay Kirby | | 81 | 70 | 11 |
| 1974-04-23 | vs CHN | 15 | W 5-3 | 8-7 | 3 | 9,663 | Roger Nelson | Ken Frailing | Roger Nelson | Ken Frailing | Pedro Borbon | 86 | 73 | 13 |
| 1974-04-24 | vs CHN | 16 | W 1-0 | 9-7 | 3 | 11,529 | Jack Billingham | Bill Bonham | Jack Billingham | Bill Bonham | | 87 | 73 | 14 |
| 1974-04-26 | @ SLN | 17 | W 4-3 | 10-7 | 2 | 28,608 | Don Gullett | John Curtis | Don Gullett | John Curtis | Pedro Borbon | 91 | 76 | 15 |
| 1974-04-27 | @ SLN | 18 | L 3-4 | 10-8 | 3 | 17,417 | Fred Norman | Alan Foster | Orlando Pena | Pedro Borbon | | 94 | 80 | 14 |
| 1974-04-28 | @ SLN | 19 | L 2-9 | 10-9 | 3 | 21,146 | Clay Kirby | Bob Gibson | Bob Gibson | Clay Kirby | | 96 | 89 | 7 |
| 1974-05-01 | @ PIT | 20 | W 5-3 | 11-9 | 3 | 8,195 | Don Gullett | Dock Ellis | Clay Carroll | John Morlan | Pedro Borbon | 101 | 92 | 9 |
| 1974-05-03 | @ CHN | 21 | L 5-6 | 11-10 | 3 | 4,157 | Clay Kirby | Burt Hooton | Horacio Pina | Don Gullett | | 106 | 98 | 8 |
| 1974-05-04 | @ CHN | 22 | L 2-3 | 11-11 | 3 | 17,924 | Roger Nelson | Ken Frailing | Rick Reuschel | Fred Norman | | 108 | 101 | 7 |
| 1974-05-05 | @ CHN | 23 | W 5-2 | 12-11 | 3 | 18,183 | Jack Billingham | Bill Bonham | Jack Billingham | Bill Bonham | Pedro Borbon | 113 | 103 | 10 |
| 1974-05-07 | vs SLN | 24 | L 0-1 | 12-12 | 4 | 10,455 | Fred Norman | Lynn McGlothen | Lynn McGlothen | Fred Norman | | 113 | 104 | 9 |
| 1974-05-08 | vs SLN | 25 | L 0-2 | 12-13 | 4 | 9,864 | Don Gullett | John Curtis | John Curtis | Don Gullett | | 113 | 106 | 7 |
| 1974-05-10 | vs HOU | 26 | W 2-1 | 13-13 | 4 | 31,463 | Jack Billingham | Larry Dierker | Jack Billingham | Larry Dierker | | 115 | 107 | 8 |
| 1974-05-11 | vs HOU | 27 | L 2-4 | 13-14 | 4 | 27,754 | Roger Nelson | Tom Griffin | Tom Griffin | Roger Nelson | | 117 | 111 | 6 |
| 1974-05-12 | vs HOU | 28 | W 5-0 | 15-14 | 4 | 0 | Fred Norman | Claude Osteen | Fred Norman | Claude Osteen | | 122 | 111 | 11 |
| 1974-05-12 | vs HOU | 29 | W 4-2 | 15-14 | 4 | 33,392 | Clay Kirby | Don Wilson | Clay Kirby | Don Wilson | | 126 | 113 | 13 |
| 1974-05-13 | vs SFN | 30 | W 4-1 | 16-14 | 4 | 12,586 | Don Gullett | John D'Acquisto | Don Gullett | John D'Acquisto | Pedro Borbon | 130 | 114 | 16 |
| 1974-05-14 | vs SFN | 31 | L 0-4 | 16-15 | 4 | 16,331 | Jack Billingham | Mike Caldwell | Mike Caldwell | Jack Billingham | | 130 | 118 | 12 |
| 1974-05-15 | vs SFN | 32 | W 4-3 | 17-15 | 3 | 14,227 | Roger Nelson | Tom Bradley | Roger Nelson | Tom Bradley | Pedro Borbon | 134 | 121 | 13 |
| 1974-05-17 | @ HOU | 33 | W 4-2 | 18-15 | 2 | 16,652 | Fred Norman | Claude Osteen | Fred Norman | Claude Osteen | Clay Carroll | 138 | 123 | 15 |
| 1974-05-18 | @ HOU | 34 | W 7-6 | 19-15 | 2 | 19,390 | Clay Kirby | Don Wilson | Pedro Borbon | Fred Scherman | | 145 | 129 | 16 |
| 1974-05-19 | @ HOU | 35 | W 7-1 | 20-15 | 2 | 15,508 | Don Gullett | Dave Roberts | Don Gullett | Dave Roberts | | 152 | 130 | 22 |
| 1974-05-20 | @ LAN | 36 | L 3-5 | 20-16 | 2 | 37,339 | Jack Billingham | Tommy John | Tommy John | Jack Billingham | Mike Marshall | 155 | 135 | 20 |
| 1974-05-21 | @ LAN | 37 | L 2-3 | 20-17 | 2 | 28,767 | Roger Nelson | Doug Rau | Mike Marshall | Pedro Borbon | | 157 | 138 | 19 |
| 1974-05-22 | @ LAN | 38 | L 3-6 | 20-18 | 2 | 32,187 | Fred Norman | Al Downing | Al Downing | Fred Norman | Mike Marshall | 160 | 144 | 16 |
| 1974-05-23 | @ SDN | 39 | L 4-5 | 20-19 | 3 | 8,167 | Clay Kirby | Steve Arlin | Dan Spillner | Fred Norman | | 164 | 149 | 15 |
| 1974-05-24 | @ SDN | 40 | W 6-3 | 21-19 | 3 | 15,987 | Don Gullett | Bill Greif | Don Gullett | Bill Greif | | 170 | 152 | 18 |
| 1974-05-25 | @ SDN | 41 | W 12-4 | 22-19 | 2 | 44,504 | Jack Billingham | Steve Arlin | Jack Billingham | Steve Arlin | | 182 | 156 | 26 |
| 1974-05-26 | @ SDN | 42 | W 4-1 | 23-19 | 2 | 13,501 | Roger Nelson | Dave Freisleben | Roger Nelson | Dave Freisleben | | 186 | 157 | 29 |
| 1974-05-27 | vs NYN | 43 | W 4-2 | 24-19 | 2 | 20,057 | Fred Norman | Tom Seaver | Fred Norman | Tom Seaver | | 190 | 159 | 31 |
| 1974-05-28 | vs NYN | 44 | W 7-2 | 25-19 | 2 | 14,017 | Clay Kirby | George Stone | Clay Kirby | George Stone | | 197 | 161 | 36 |
| 1974-05-29 | vs NYN | 45 | W 3-2 | 26-19 | 2 | 16,339 | Don Gullett | Jon Matlack | Clay Carroll | Harry Parker | | 200 | 163 | 37 |
| 1974-05-31 | vs PIT | 46 | W 7-5 | 27-19 | 2 | 40,205 | Jack Billingham | Jim Rooker | Pedro Borbon | Jim Rooker | | 207 | 168 | 39 |
| 1974-06-01 | vs PIT | 47 | L 1-14 | 27-20 | 2 | 36,999 | Roger Nelson | Ken Brett | Ken Brett | Roger Nelson | | 208 | 182 | 26 |
| 1974-06-02 | vs PIT | 48 | W 5-1 | 28-20 | 2 | 38,354 | Fred Norman | Bruce Kison | Fred Norman | Bruce Kison | | 213 | 183 | 30 |
| 1974-06-03 | @ NYN | 49 | W 5-2 | 29-20 | 2 | 23,065 | Clay Kirby | Jon Matlack | Clay Kirby | Jon Matlack | | 218 | 185 | 33 |
| 1974-06-04 | @ NYN | 50 | W 6-3 | 30-20 | 2 | 23,333 | Don Gullett | Jerry Koosman | Pedro Borbon | Ray Sadecki | | 224 | 188 | 36 |
| 1974-06-06 | @ NYN | 51 | L 3-4 | 30-21 | 2 | 19,502 | Roger Nelson | Tom Seaver | Ray Sadecki | Pedro Borbon | | 227 | 192 | 35 |
| 1974-06-07 | @ PHI | 52 | W 7-4 | 31-21 | 2 | 22,408 | Dick Baney | Dick Ruthven | Pedro Borbon | Mac Scarce | | 234 | 196 | 38 |
| 1974-06-08 | @ PHI | 53 | L 5-6 | 31-22 | 2 | 0 | Clay Kirby | Steve Carlton | Steve Carlton | Clay Carroll | | 239 | 202 | 37 |
| 1974-06-09 | @ PHI | 54 | W 14-7 | 32-22 | 2 | 33,163 | Don Gullett | Ron Schueler | Don Gullett | Wayne Twitchell | | 253 | 209 | 44 |
| 1974-06-10 | @ MON | 55 | L 1-3 | 32-23 | 2 | 14,192 | Jack Billingham | Steve Renko | Steve Renko | Jack Billingham | Chuck Taylor | 254 | 212 | 42 |
| 1974-06-11 | @ MON | 56 | L 6-16 | 32-24 | 2 | 12,450 | Roger Nelson | Dennis Blair | Tom Walker | Tom Hall | | 260 | 228 | 32 |
| 1974-06-12 | @ MON | 57 | W 3-1 | 33-24 | 2 | 11,531 | Clay Kirby | Steve Rogers | Clay Kirby | Steve Rogers | | 263 | 229 | 34 |
| 1974-06-14 | vs PHI | 58 | W 7-4 | 34-24 | 2 | 25,238 | Don Gullett | Ron Schueler | Don Gullett | Ron Schueler | | 270 | 233 | 37 |
| 1974-06-15 | vs PHI | 59 | L 2-5 | 34-25 | 2 | 35,732 | Jack Billingham | Jim Lonborg | Jim Lonborg | Jack Billingham | | 272 | 238 | 34 |
| 1974-06-16 | vs PHI | 60 | W 5-0 | 35-25 | 2 | 30,006 | Clay Carroll | Dick Ruthven | Clay Carroll | Dick Ruthven | | 277 | 238 | 39 |
| 1974-06-17 | vs MON | 61 | W 12-3 | 36-25 | 2 | 18,001 | Fred Norman | Steve Rogers | Fred Norman | Steve Rogers | | 289 | 241 | 48 |
| 1974-06-18 | vs MON | 62 | L 1-2 | 36-26 | 2 | 21,656 | Clay Kirby | Ernie McAnally | Ernie McAnally | Clay Kirby | | 290 | 243 | 47 |
| 1974-06-19 | vs MON | 63 | L 2-4 | 36-27 | 3 | 22,344 | Don Gullett | Mike Torrez | Mike Torrez | Don Gullett | John Montague | 292 | 247 | 45 |
| 1974-06-21 | vs ATL | 64 | L 0-1 | 36-28 | 3 | 31,128 | Jack Billingham | Carl Morton | Carl Morton | Jack Billingham | Tom House | 292 | 248 | 44 |
| 1974-06-22 | vs ATL | 65 | W 3-2 | 37-28 | 3 | 38,081 | Fred Norman | Phil Niekro | Fred Norman | Phil Niekro | | 295 | 250 | 45 |
| 1974-06-23 | vs ATL | 66 | W 4-2 | 39-28 | 2 | 0 | Roger Nelson | Roric Harrison | Roger Nelson | Roric Harrison | | 299 | 252 | 47 |
| 1974-06-23 | vs ATL | 67 | W 2-1 | 39-28 | 2 | 52,147 | Clay Kirby | Lew Krausse | Pedro Borbon | Joe Niekro | | 301 | 253 | 48 |
| 1974-06-24 | @ HOU | 68 | L 1-6 | 39-29 | 2 | 16,428 | Don Gullett | Tom Griffin | Tom Griffin | Don Gullett | | 302 | 259 | 43 |
| 1974-06-25 | @ HOU | 69 | W 3-2 | 40-29 | 2 | 21,449 | Jack Billingham | Larry Dierker | Jack Billingham | Larry Dierker | Clay Carroll | 305 | 261 | 44 |
| 1974-06-26 | @ HOU | 70 | W 9-1 | 41-29 | 2 | 17,647 | Fred Norman | Don Wilson | Fred Norman | Don Wilson | | 314 | 262 | 52 |
| 1974-06-27 | @ ATL | 71 | W 6-3 | 42-29 | 2 | 14,384 | Clay Kirby | Phil Niekro | Clay Kirby | Phil Niekro | Pedro Borbon | 320 | 265 | 55 |
| 1974-06-28 | @ ATL | 72 | W 6-5 | 43-30 | 2 | 0 | Clay Carroll | Roric Harrison | Clay Carroll | Roric Harrison | Pedro Borbon | 326 | 270 | 56 |
| 1974-06-28 | @ ATL | 73 | L 0-1 | 43-30 | 2 | 33,728 | Don Gullett | Buzz Capra | Buzz Capra | Don Gullett | | 326 | 271 | 55 |
| 1974-06-29 | @ ATL | 74 | W 2-1 | 44-30 | 2 | 41,427 | Jack Billingham | Ron Reed | Jack Billingham | Ron Reed | | 328 | 272 | 56 |
| 1974-06-30 | @ ATL | 75 | L 3-7 | 44-31 | 2 | 25,546 | Fred Norman | Carl Morton | Carl Morton | Fred Norman | | 331 | 279 | 52 |
| 1974-07-02 | vs LAN | 76 | L 2-3 | 44-32 | 2 | 33,210 | Clay Kirby | Don Sutton | Mike Marshall | Pedro Borbon | | 333 | 282 | 51 |
| 1974-07-03 | vs LAN | 77 | L 1-4 | 45-33 | 2 | 0 | Clay Carroll | Tommy John | Tommy John | Clay Carroll | Mike Marshall | 334 | 286 | 48 |
| 1974-07-03 | vs LAN | 78 | W 6-0 | 45-33 | 2 | 51,909 | Don Gullett | Doug Rau | Don Gullett | Doug Rau | | 340 | 286 | 54 |
| 1974-07-04 | vs LAN | 79 | L 2-3 | 45-34 | 2 | 30,170 | Jack Billingham | Andy Messersmith | Mike Marshall | Pedro Borbon | | 342 | 289 | 53 |
| 1974-07-05 | vs SLN | 80 | L 2-3 | 45-35 | 2 | 26,066 | Fred Norman | Alan Foster | Rich Folkers | Fred Norman | Mike Garman | 344 | 292 | 52 |
| 1974-07-06 | vs SLN | 81 | L 1-3 | 45-36 | 2 | 33,989 | Clay Kirby | Bob Gibson | Bob Gibson | Clay Kirby | | 345 | 295 | 50 |
| 1974-07-07 | vs SLN | 82 | W 2-1 | 47-36 | 2 | 0 | Tom Carroll | Bob Forsch | Tom Carroll | Bob Forsch | Will McEnaney | 347 | 296 | 51 |
| 1974-07-07 | vs SLN | 83 | W 11-2 | 47-36 | 2 | 46,016 | Don Gullett | Mike Thompson | Don Gullett | Mike Thompson | | 358 | 298 | 60 |
| 1974-07-09 | @ CHN | 84 | W 8-5 | 48-36 | 2 | 19,015 | Jack Billingham | Steve Stone | Jack Billingham | Steve Stone | Pedro Borbon | 366 | 303 | 63 |
| 1974-07-10 | @ CHN | 85 | L 3-11 | 48-37 | 2 | 16,450 | Fred Norman | Bill Bonham | Bill Bonham | Fred Norman | Oscar Zamora | 369 | 314 | 55 |
| 1974-07-11 | @ CHN | 86 | W 4-3 | 49-37 | 2 | 17,200 | Clay Kirby | Dave LaRoche | Pedro Borbon | Burt Hooton | | 373 | 317 | 56 |
| 1974-07-12 | @ PIT | 87 | W 7-0 | 51-37 | 2 | 0 | Don Gullett | Jim Rooker | Don Gullett | Jim Rooker | | 380 | 317 | 63 |
| 1974-07-12 | @ PIT | 88 | W 4-3 | 51-37 | 2 | 30,507 | Tom Carroll | Larry Demery | Tom Carroll | Larry Demery | Clay Carroll | 384 | 320 | 64 |
| 1974-07-13 | @ PIT | 89 | W 9-4 | 52-37 | 2 | 15,386 | Tom Hall | Jerry Reuss | Tom Hall | Jerry Reuss | Pedro Borbon | 393 | 324 | 69 |
| 1974-07-14 | @ PIT | 90 | W 3-2 | 53-38 | 2 | 0 | Fred Norman | Ken Brett | Fred Norman | Ken Brett | Clay Carroll | 396 | 326 | 70 |
| 1974-07-14 | @ PIT | 91 | L 1-2 | 53-38 | 2 | 27,151 | Jack Billingham | Bruce Kison | Bruce Kison | Jack Billingham | Dave Giusti | 397 | 328 | 69 |
| 1974-07-15 | @ SLN | 92 | W 3-0 | 54-38 | 2 | 21,316 | Clay Kirby | Alan Foster | Clay Kirby | Alan Foster | | 400 | 328 | 72 |
| 1974-07-16 | @ SLN | 93 | W 12-7 | 55-38 | 2 | 18,588 | Don Gullett | Bob Forsch | Don Gullett | Bob Forsch | | 412 | 335 | 77 |
| 1974-07-17 | @ SLN | 94 | W 6-4 | 56-38 | 2 | 28,743 | Tom Carroll | Bob Gibson | Will McEnaney | Rich Folkers | Pedro Borbon | 418 | 339 | 79 |
| 1974-07-18 | vs CHN | 95 | L 2-3 | 56-39 | 2 | 28,459 | Fred Norman | Bill Bonham | Bill Bonham | Fred Norman | Oscar Zamora | 420 | 342 | 78 |
| 1974-07-19 | vs CHN | 96 | W 4-1 | 57-39 | 2 | 42,430 | Jack Billingham | Dave LaRoche | Jack Billingham | Dave LaRoche | Pedro Borbon | 424 | 343 | 81 |
| 1974-07-20 | vs CHN | 97 | L 6-11 | 57-40 | 2 | 45,017 | Clay Kirby | Rick Reuschel | Oscar Zamora | Clay Carroll | | 430 | 354 | 76 |
| 1974-07-21 | vs CHN | 98 | W 8-2 | 58-40 | 2 | 34,031 | Don Gullett | Burt Hooton | Don Gullett | Burt Hooton | | 438 | 356 | 82 |
| 1974-07-25 | vs SFN | 99 | W 14-13 | 60-40 | 2 | 0 | Clay Kirby | Mike Caldwell | Jack Billingham | Randy Moffitt | | 452 | 369 | 83 |
| 1974-07-25 | vs SFN | 100 | W 5-0 | 60-40 | 2 | 40,025 | Fred Norman | Ed Halicki | Fred Norman | Ed Halicki | | 457 | 369 | 88 |
| 1974-07-26 | vs SFN | 101 | L 4-5 | 60-41 | 2 | 30,094 | Don Gullett | Jim Barr | Jim Barr | Don Gullett | Elias Sosa | 461 | 374 | 87 |
| 1974-07-27 | vs SDN | 102 | W 5-1 | 61-41 | 2 | 42,350 | Tom Carroll | Dave Freisleben | Tom Carroll | Dave Freisleben | | 466 | 375 | 91 |
| 1974-07-28 | vs SDN | 103 | W 14-1 | 62-41 | 2 | 30,975 | Jack Billingham | Dan Spillner | Jack Billingham | Dan Spillner | | 480 | 376 | 104 |
| 1974-07-29 | vs SDN | 104 | L 2-3 | 62-42 | 2 | 20,082 | Clay Kirby | Bill Greif | Bill Greif | Clay Kirby | | 482 | 379 | 103 |
| 1974-07-30 | vs HOU | 105 | L 4-8 | 62-43 | 2 | 27,057 | Fred Norman | Don Wilson | Don Wilson | Fred Norman | | 486 | 387 | 99 |
| 1974-07-31 | vs HOU | 106 | W 4-0 | 63-43 | 2 | 26,253 | Don Gullett | Tom Griffin | Don Gullett | Tom Griffin | | 490 | 387 | 103 |
| 1974-08-01 | @ SFN | 107 | W 9-7 | 64-43 | 2 | 3,818 | Tom Carroll | Charlie Williams | Clay Carroll | Ron Bryant | | 499 | 394 | 105 |
| 1974-08-02 | @ SFN | 108 | W 9-4 | 65-43 | 2 | 6,737 | Jack Billingham | Ed Halicki | Jack Billingham | Ed Halicki | | 508 | 398 | 110 |
| 1974-08-04 | @ SDN | 109 | W 7-2 | 66-44 | 2 | 0 | Fred Norman | Randy Jones | Dick Baney | Randy Jones | | 515 | 400 | 115 |
| 1974-08-04 | @ SDN | 110 | L 0-1 | 66-44 | 2 | 19,883 | Clay Kirby | Dave Freisleben | Rusty Gerhardt | Pedro Borbon | | 515 | 401 | 114 |
| 1974-08-05 | @ LAN | 111 | L 3-6 | 66-45 | 2 | 45,577 | Don Gullett | Doug Rau | Doug Rau | Don Gullett | | 518 | 407 | 111 |
| 1974-08-06 | @ LAN | 112 | W 6-3 | 67-45 | 2 | 53,472 | Tom Carroll | Don Sutton | Pedro Borbon | Mike Marshall | | 524 | 410 | 114 |
| 1974-08-07 | @ LAN | 113 | W 2-0 | 68-45 | 2 | 54,038 | Jack Billingham | Andy Messersmith | Jack Billingham | Andy Messersmith | | 526 | 410 | 116 |
| 1974-08-09 | @ NYN | 114 | L 1-4 | 68-46 | 2 | 27,391 | Fred Norman | Bob Apodaca | Bob Apodaca | Fred Norman | | 527 | 414 | 113 |
| 1974-08-10 | @ NYN | 115 | W 5-3 | 69-46 | 2 | 40,359 | Don Gullett | Tom Seaver | Clay Carroll | Ray Sadecki | | 532 | 417 | 115 |
| 1974-08-11 | @ NYN | 116 | W 10-4 | 70-46 | 2 | 40,588 | Tom Carroll | Jerry Koosman | Tom Carroll | Jerry Koosman | Tom Hall | 542 | 421 | 121 |
| 1974-08-12 | vs PIT | 117 | L 4-7 | 70-47 | 2 | 30,327 | Clay Kirby | Jerry Reuss | Jerry Reuss | Clay Kirby | Dave Giusti | 546 | 428 | 118 |
| 1974-08-13 | vs PIT | 118 | L 3-14 | 70-48 | 2 | 32,280 | Jack Billingham | Larry Demery | Larry Demery | Jack Billingham | | 549 | 442 | 107 |
| 1974-08-14 | vs PIT | 119 | W 3-2 | 71-48 | 2 | 30,018 | Don Gullett | Jim Rooker | Clay Carroll | Bruce Kison | | 552 | 444 | 108 |
| 1974-08-16 | vs NYN | 120 | L 1-2 | 71-49 | 2 | 36,480 | Tom Carroll | Jerry Koosman | Tug McGraw | Will McEnaney | | 553 | 446 | 107 |
| 1974-08-17 | vs NYN | 121 | W 6-2 | 72-49 | 2 | 47,274 | Jack Billingham | Harry Parker | Jack Billingham | Harry Parker | | 559 | 448 | 111 |
| 1974-08-18 | vs NYN | 122 | W 6-5 | 73-49 | 2 | 45,025 | Fred Norman | Jon Matlack | Clay Carroll | Jon Matlack | Will McEnaney | 565 | 453 | 112 |
| 1974-08-19 | vs PHI | 123 | W 15-2 | 74-49 | 2 | 21,806 | Don Gullett | Wayne Twitchell | Don Gullett | Wayne Twitchell | | 580 | 455 | 125 |
| 1974-08-20 | vs PHI | 124 | W 7-1 | 75-49 | 2 | 30,448 | Clay Kirby | Ron Schueler | Clay Kirby | Ron Schueler | | 587 | 456 | 131 |
| 1974-08-21 | vs PHI | 125 | L 3-10 | 75-50 | 2 | 31,887 | Tom Carroll | Jim Lonborg | Jim Lonborg | Tom Carroll | | 590 | 466 | 124 |
| 1974-08-23 | @ MON | 126 | W 10-7 | 76-50 | 2 | 20,468 | Jack Billingham | Tom Walker | Clay Carroll | Tom Walker | | 600 | 473 | 127 |
| 1974-08-24 | @ MON | 127 | W 6-4 | 77-50 | 2 | 18,466 | Don Gullett | Steve Rogers | Don Gullett | Steve Rogers | | 606 | 477 | 129 |
| 1974-08-25 | @ MON | 128 | W 3-1 | 78-50 | 2 | 21,161 | Clay Kirby | Dennis Blair | Clay Kirby | Dennis Blair | | 609 | 478 | 131 |
| 1974-08-26 | @ PHI | 129 | L 6-7 | 78-51 | 2 | 27,197 | Tom Carroll | Jim Lonborg | Ron Schueler | Clay Carroll | | 615 | 485 | 130 |
| 1974-08-27 | @ PHI | 130 | W 3-0 | 79-51 | 2 | 32,106 | Jack Billingham | Dick Ruthven | Jack Billingham | Dick Ruthven | | 618 | 485 | 133 |
| 1974-08-28 | @ PHI | 131 | W 4-3 | 80-51 | 2 | 0 | Don Gullett | Steve Carlton | Will McEnaney | Ron Schueler | Dick Baney | 622 | 488 | 134 |
| 1974-08-30 | vs MON | 132 | L 3-11 | 80-52 | 2 | 26,714 | Clay Kirby | Dennis Blair | Dennis Blair | Clay Kirby | | 625 | 499 | 126 |
| 1974-08-31 | vs MON | 133 | W 10-3 | 81-52 | 2 | 34,101 | Jack Billingham | Steve Renko | Jack Billingham | Steve Renko | | 635 | 502 | 133 |
| 1974-09-01 | vs MON | 134 | L 1-2 | 81-53 | 2 | 30,037 | Don Gullett | Mike Torrez | Mike Torrez | Don Gullett | | 636 | 504 | 132 |
| 1974-09-02 | @ HOU | 135 | L 3-4 | 81-54 | 2 | 8,750 | Tom Carroll | Larry Dierker | Larry Dierker | Tom Carroll | Ken Forsch | 639 | 508 | 131 |
| 1974-09-03 | @ HOU | 136 | W 7-5 | 82-54 | 2 | 6,894 | Clay Kirby | Dave Roberts | Pedro Borbon | Ken Forsch | | 646 | 513 | 133 |
| 1974-09-04 | @ HOU | 137 | W 2-1 | 83-54 | 2 | 8,024 | Jack Billingham | Don Wilson | Jack Billingham | Don Wilson | | 648 | 514 | 134 |
| 1974-09-06 | vs LAN | 138 | L 1-3 | 83-55 | 2 | 51,083 | Don Gullett | Don Sutton | Don Sutton | Don Gullett | Mike Marshall | 649 | 517 | 132 |
| 1974-09-07 | vs LAN | 139 | W 7-5 | 84-55 | 2 | 50,014 | Clay Kirby | Andy Messersmith | Clay Carroll | Mike Marshall | | 656 | 522 | 134 |
| 1974-09-08 | vs LAN | 140 | L 4-7 | 84-56 | 2 | 51,465 | Jack Billingham | Doug Rau | Doug Rau | Jack Billingham | | 660 | 529 | 131 |
| 1974-09-09 | vs SDN | 141 | W 8-3 | 85-56 | 2 | 11,023 | Fred Norman | Dave Freisleben | Fred Norman | Dave Freisleben | Pedro Borbon | 668 | 532 | 136 |
| 1974-09-10 | vs SDN | 142 | W 5-2 | 86-56 | 2 | 12,181 | Don Gullett | Joe McIntosh | Don Gullett | Joe McIntosh | | 673 | 534 | 139 |
| 1974-09-11 | vs ATL | 143 | W 1-1 | 87-56 | 2 | 0 | Clay Kirby | Phil Niekro | | | | 674 | 535 | 139 |
| 1974-09-12 | vs ATL | 144 | W 9-6 | 89-56 | 2 | 0 | Tom Carroll | Ron Reed | Pedro Borbon | Ron Reed | Clay Carroll | 683 | 541 | 142 |
| 1974-09-12 | vs ATL | 145 | W 6-2 | 89-56 | 2 | 22,628 | Pat Darcy | Lew Krausse | Pat Darcy | Lew Krausse | | 689 | 543 | 146 |
| 1974-09-13 | @ LAN | 146 | W 6-3 | 90-56 | 2 | 52,337 | Jack Billingham | Doug Rau | Jack Billingham | Doug Rau | | 695 | 546 | 149 |
| 1974-09-14 | @ LAN | 147 | W 4-2 | 91-56 | 2 | 52,970 | Don Gullett | Geoff Zahn | Don Gullett | Geoff Zahn | Clay Carroll | 699 | 548 | 151 |
| 1974-09-15 | @ LAN | 148 | L 1-7 | 91-57 | 2 | 52,116 | Fred Norman | Don Sutton | Don Sutton | Fred Norman | | 700 | 555 | 145 |
| 1974-09-16 | @ SDN | 149 | W 9-2 | 92-57 | 2 | 5,467 | Clay Kirby | Dan Spillner | Clay Kirby | Dan Spillner | | 709 | 557 | 152 |
| 1974-09-17 | @ SDN | 150 | L 1-6 | 92-58 | 2 | 6,428 | Jack Billingham | Bill Greif | Bill Greif | Jack Billingham | | 710 | 563 | 147 |
| 1974-09-18 | @ SDN | 151 | L 5-6 | 92-59 | 2 | 33,237 | Don Gullett | Randy Jones | Randy Jones | Clay Carroll | Larry Hardy | 715 | 569 | 146 |
| 1974-09-19 | @ SFN | 152 | W 8-4 | 93-59 | 2 | 2,074 | Fred Norman | John D'Acquisto | Fred Norman | John D'Acquisto | | 723 | 573 | 150 |
| 1974-09-20 | @ SFN | 153 | L 3-4 | 93-60 | 2 | 3,924 | Clay Kirby | Mike Caldwell | Mike Caldwell | Clay Kirby | | 726 | 577 | 149 |
| 1974-09-21 | @ SFN | 154 | L 6-8 | 93-61 | 2 | 5,455 | Jack Billingham | Jim Barr | Butch Metzger | Pedro Borbon | | 732 | 585 | 147 |
| 1974-09-22 | @ SFN | 155 | L 0-6 | 93-62 | 2 | 16,801 | Don Gullett | John Montefusco | John Montefusco | Don Gullett | | 732 | 591 | 141 |
| 1974-09-24 | vs HOU | 156 | W 5-1 | 94-62 | 2 | 12,487 | Fred Norman | Tom Griffin | Fred Norman | Tom Griffin | | 737 | 592 | 145 |
| 1974-09-25 | vs HOU | 157 | W 4-1 | 95-62 | 2 | 10,186 | Clay Kirby | Larry Dierker | Clay Kirby | Larry Dierker | Rawly Eastwick | 741 | 593 | 148 |
| 1974-09-26 | vs HOU | 158 | W 10-6 | 96-62 | 2 | 11,784 | Jack Billingham | J.R. Richard | Tom Hall | Jim York | Rawly Eastwick | 751 | 599 | 152 |
| 1974-09-27 | vs SFN | 159 | W 4-3 | 97-62 | 2 | 18,967 | Pat Darcy | Jim Barr | Tom Hall | Gary Lavelle | | 755 | 602 | 153 |
| 1974-09-28 | vs SFN | 160 | W 13-6 | 98-62 | 2 | 28,158 | Fred Norman | John Montefusco | Clay Carroll | Gary Lavelle | | 768 | 608 | 160 |
| 1974-09-29 | vs SFN | 161 | W 7-3 | 99-62 | 2 | 50,342 | Clay Kirby | John D'Acquisto | Clay Kirby | John D'Acquisto | | 775 | 611 | 164 |
| 1974-10-01 | @ ATL | 162 | L 1-7 | 99-63 | 2 | 4,257 | Jack Billingham | Buzz Capra | Buzz Capra | Jack Billingham | | 776 | 618 | 158 |
| 1974-10-02 | @ ATL | 163 | L 0-13 | 99-64 | 2 | 11,081 | Tom Carroll | Phil Niekro | Phil Niekro | Tom Carroll | | 776 | 631 | 145 |