| 1974-04-09 | vs PHI | 1 | W 2-0 | 1-0 | 1 | 30,601 | Bill Bonham | Ron Schueler | Bill Bonham | Ron Schueler | | 2 | 0 | 2 |
| 1974-04-10 | vs PHI | 2 | W 7-6 | 2-0 | 1 | 6,535 | Rick Reuschel | Dick Ruthven | Ray Burris | Mac Scarce | | 9 | 6 | 3 |
| 1974-04-11 | vs PHI | 3 | L 3-4 | 2-1 | 3 | 2,292 | Burt Hooton | Steve Carlton | Frank Linzy | Horacio Pina | Eddie Watt | 12 | 10 | 2 |
| 1974-04-13 | vs MON | 4 | W 7-4 | 3-2 | 3 | 0 | Ken Frailing | Ernie McAnally | Ken Frailing | Ernie McAnally | | 19 | 14 | 5 |
| 1974-04-13 | vs MON | 5 | L 3-13 | 3-2 | 3 | 30,066 | Bill Bonham | Mike Torrez | Mike Torrez | Bill Bonham | | 22 | 27 | -5 |
| 1974-04-16 | vs PIT | 6 | L 5-8 | 3-3 | 4 | 14,953 | Rick Reuschel | Dock Ellis | Bruce Kison | Mike Paul | | 27 | 35 | -8 |
| 1974-04-17 | vs PIT | 7 | W 18-9 | 4-3 | 4 | 15,560 | Burt Hooton | Jerry Reuss | Burt Hooton | Jerry Reuss | | 45 | 44 | 1 |
| 1974-04-18 | vs PIT | 8 | W 1-0 | 5-3 | 3 | 13,054 | Ken Frailing | Jim Rooker | Ken Frailing | Jim Rooker | Ray Burris | 46 | 44 | 2 |
| 1974-04-19 | @ PHI | 9 | L 2-9 | 5-4 | 4 | 12,318 | Bill Bonham | Jim Lonborg | Jim Lonborg | Bill Bonham | | 48 | 53 | -5 |
| 1974-04-20 | @ PHI | 10 | W 5-4 | 6-4 | 3 | 16,534 | Rick Reuschel | Dick Ruthven | Ray Burris | Mac Scarce | | 53 | 57 | -4 |
| 1974-04-21 | @ PHI | 11 | L 3-7 | 6-5 | 4 | 17,172 | Burt Hooton | Steve Carlton | Steve Carlton | Burt Hooton | | 56 | 64 | -8 |
| 1974-04-23 | @ CIN | 12 | L 3-5 | 6-6 | 4 | 9,663 | Ken Frailing | Roger Nelson | Roger Nelson | Ken Frailing | Pedro Borbon | 59 | 69 | -10 |
| 1974-04-24 | @ CIN | 13 | L 0-1 | 6-7 | 4 | 11,529 | Bill Bonham | Jack Billingham | Jack Billingham | Bill Bonham | | 59 | 70 | -11 |
| 1974-04-26 | @ ATL | 14 | L 3-9 | 6-8 | 4 | 6,829 | Rick Reuschel | Carl Morton | Carl Morton | Jim Kremmel | | 62 | 79 | -17 |
| 1974-04-27 | @ ATL | 15 | L 2-5 | 6-9 | 4 | 12,181 | Burt Hooton | Roric Harrison | Roric Harrison | Burt Hooton | | 64 | 84 | -20 |
| 1974-04-28 | @ ATL | 16 | W 4-3 | 7-9 | 4 | 10,418 | Ken Frailing | Phil Niekro | Horacio Pina | Jack Aker | | 68 | 87 | -19 |
| 1974-04-29 | @ HOU | 17 | L 2-18 | 7-10 | 4 | 8,335 | Bill Bonham | Dave Roberts | Dave Roberts | Bill Bonham | | 70 | 105 | -35 |
| 1974-04-30 | @ HOU | 18 | L 2-4 | 7-11 | 4 | 7,603 | Steve Stone | Larry Dierker | Ken Forsch | Horacio Pina | | 72 | 109 | -37 |
| 1974-05-01 | @ HOU | 19 | L 7-11 | 7-12 | 4 | 9,619 | Rick Reuschel | Tom Griffin | Don Wilson | Rick Reuschel | | 79 | 120 | -41 |
| 1974-05-03 | vs CIN | 20 | W 6-5 | 8-12 | 4 | 4,157 | Burt Hooton | Clay Kirby | Horacio Pina | Don Gullett | | 85 | 125 | -40 |
| 1974-05-04 | vs CIN | 21 | W 3-2 | 9-12 | 4 | 17,924 | Ken Frailing | Roger Nelson | Rick Reuschel | Fred Norman | | 88 | 127 | -39 |
| 1974-05-05 | vs CIN | 22 | L 2-5 | 9-13 | 4 | 18,183 | Bill Bonham | Jack Billingham | Jack Billingham | Bill Bonham | Pedro Borbon | 90 | 132 | -42 |
| 1974-05-07 | vs ATL | 23 | W 3-2 | 10-13 | 4 | 6,523 | Steve Stone | Carl Morton | Steve Stone | Carl Morton | Horacio Pina | 93 | 134 | -41 |
| 1974-05-09 | vs ATL | 24 | W 3-1 | 11-13 | 4 | 6,393 | Rick Reuschel | Roric Harrison | Rick Reuschel | Roric Harrison | | 96 | 135 | -39 |
| 1974-05-10 | vs NYN | 25 | L 2-7 | 11-14 | 4 | 4,385 | Burt Hooton | Jerry Koosman | Jerry Koosman | Burt Hooton | | 98 | 142 | -44 |
| 1974-05-11 | vs NYN | 26 | L 3-6 | 11-15 | 5 | 9,481 | Ken Frailing | Craig Swan | Craig Swan | Ken Frailing | | 101 | 148 | -47 |
| 1974-05-12 | vs NYN | 27 | W 4-3 | 12-15 | 4 | 9,581 | Steve Stone | Tom Seaver | Bill Bonham | Tom Seaver | | 105 | 151 | -46 |
| 1974-05-14 | @ PIT | 28 | W 7-1 | 13-15 | 4 | 6,541 | Rick Reuschel | Jerry Reuss | Rick Reuschel | Jerry Reuss | | 112 | 152 | -40 |
| 1974-05-15 | @ PIT | 29 | L 2-3 | 13-16 | 4 | 6,873 | Burt Hooton | Jim Rooker | Bruce Kison | Bill Bonham | | 114 | 155 | -41 |
| 1974-05-16 | @ PIT | 30 | L 2-5 | 13-17 | 5 | 5,845 | Ken Frailing | Ken Brett | Ken Brett | Ken Frailing | Bruce Kison | 116 | 160 | -44 |
| 1974-05-17 | @ SLN | 31 | L 8-9 | 13-18 | 5 | 21,691 | Steve Stone | Alan Foster | Orlando Pena | Bill Bonham | | 124 | 169 | -45 |
| 1974-05-18 | @ SLN | 32 | L 2-11 | 13-19 | 5 | 33,598 | Rick Reuschel | Sonny Siebert | Sonny Siebert | Rick Reuschel | | 126 | 180 | -54 |
| 1974-05-19 | @ SLN | 33 | L 5-6 | 13-20 | 5 | 29,371 | Bill Bonham | Bob Gibson | Bob Gibson | Bill Bonham | Al Hrabosky | 131 | 186 | -55 |
| 1974-05-20 | @ NYN | 34 | W 2-1 | 14-20 | 5 | 11,225 | Burt Hooton | Harry Parker | Burt Hooton | Harry Parker | | 133 | 187 | -54 |
| 1974-05-21 | @ NYN | 35 | L 5-10 | 14-21 | 5 | 11,995 | Ken Frailing | George Stone | George Stone | Ken Frailing | | 138 | 197 | -59 |
| 1974-05-22 | @ NYN | 36 | W 9-6 | 15-21 | 5 | 16,196 | Steve Stone | Tom Seaver | Dave LaRoche | Bob Apodaca | | 147 | 203 | -56 |
| 1974-05-24 | vs SLN | 37 | L 0-1 | 15-22 | 5 | 9,180 | Rick Reuschel | Sonny Siebert | Sonny Siebert | Rick Reuschel | | 147 | 204 | -57 |
| 1974-05-25 | vs SLN | 38 | W 5-4 | 16-22 | 5 | 20,237 | Bill Bonham | Bob Gibson | Bill Bonham | Bob Gibson | Dave LaRoche | 152 | 208 | -56 |
| 1974-05-26 | vs SLN | 39 | L 1-7 | 16-23 | 5 | 24,182 | Burt Hooton | Lynn McGlothen | Lynn McGlothen | Burt Hooton | | 153 | 215 | -62 |
| 1974-05-27 | vs SFN | 40 | W 12-4 | 17-23 | 5 | 18,161 | Ken Frailing | Mike Caldwell | Ken Frailing | Mike Caldwell | | 165 | 219 | -54 |
| 1974-05-29 | vs SFN | 41 | L 4-5 | 17-24 | 5 | 8,632 | Rick Reuschel | John D'Acquisto | John D'Acquisto | Rick Reuschel | Randy Moffitt | 169 | 224 | -55 |
| 1974-05-30 | vs SFN | 42 | W 5-3 | 18-24 | 4 | 12,630 | Bill Bonham | Tom Bradley | Bill Bonham | Elias Sosa | | 174 | 227 | -53 |
| 1974-05-31 | vs LAN | 43 | L 3-8 | 18-25 | 4 | 9,111 | Burt Hooton | Doug Rau | Doug Rau | Burt Hooton | Mike Marshall | 177 | 235 | -58 |
| 1974-06-01 | vs LAN | 44 | L 0-10 | 18-26 | 5 | 19,558 | Ken Frailing | Andy Messersmith | Andy Messersmith | Ken Frailing | | 177 | 245 | -68 |
| 1974-06-02 | vs LAN | 45 | W 7-6 | 19-26 | 5 | 23,044 | Rick Reuschel | Don Sutton | Rick Reuschel | Mike Marshall | Horacio Pina | 184 | 251 | -67 |
| 1974-06-04 | @ SDN | 46 | L 5-6 | 19-27 | 4 | 5,808 | Bill Bonham | Bill Greif | Larry Hardy | Dave LaRoche | Vicente Romo | 189 | 257 | -68 |
| 1974-06-05 | @ SDN | 47 | L 3-4 | 19-28 | 5 | 6,934 | Burt Hooton | Lowell Palmer | Vicente Romo | Ray Burris | | 192 | 261 | -69 |
| 1974-06-06 | @ SDN | 48 | W 5-1 | 20-28 | 5 | 6,630 | Ken Frailing | Randy Jones | Ken Frailing | Randy Jones | | 197 | 262 | -65 |
| 1974-06-07 | @ LAN | 49 | L 5-6 | 20-29 | 5 | 53,689 | Rick Reuschel | Don Sutton | Mike Marshall | Dave LaRoche | | 202 | 268 | -66 |
| 1974-06-08 | @ LAN | 50 | W 6-5 | 21-29 | 5 | 36,115 | Bill Bonham | Al Downing | Horacio Pina | Jim Brewer | | 208 | 273 | -65 |
| 1974-06-09 | @ LAN | 51 | L 3-4 | 21-30 | 5 | 32,021 | Burt Hooton | Tommy John | Charlie Hough | Horacio Pina | | 211 | 277 | -66 |
| 1974-06-11 | @ SFN | 52 | W 7-4 | 22-30 | 4 | 3,331 | Ken Frailing | John D'Acquisto | Ken Frailing | John D'Acquisto | Horacio Pina | 218 | 281 | -63 |
| 1974-06-12 | @ SFN | 53 | W 10-1 | 23-30 | 4 | 2,541 | Rick Reuschel | Tom Bradley | Rick Reuschel | Tom Bradley | | 228 | 282 | -54 |
| 1974-06-13 | @ SFN | 54 | L 0-1 | 23-31 | 4 | 2,342 | Bill Bonham | Jim Barr | Jim Barr | Bill Bonham | | 228 | 283 | -55 |
| 1974-06-14 | vs HOU | 55 | W 10-7 | 24-31 | 4 | 11,070 | Burt Hooton | Dave Roberts | Jim Todd | Dave Roberts | | 238 | 290 | -52 |
| 1974-06-15 | vs HOU | 56 | L 7-8 | 24-32 | 4 | 15,869 | Steve Stone | Tom Griffin | Fred Scherman | Horacio Pina | Dave Roberts | 245 | 298 | -53 |
| 1974-06-16 | vs HOU | 57 | W 2-1 | 25-32 | 4 | 14,865 | Rick Reuschel | Larry Dierker | Burt Hooton | Ken Forsch | | 247 | 299 | -52 |
| 1974-06-17 | vs SDN | 58 | L 5-7 | 25-33 | 4 | 6,444 | Ken Frailing | Randy Jones | Larry Hardy | Steve Stone | | 252 | 306 | -54 |
| 1974-06-18 | vs SDN | 59 | L 4-9 | 25-34 | 5 | 9,842 | Bill Bonham | Dave Freisleben | Dave Freisleben | Bill Bonham | | 256 | 315 | -59 |
| 1974-06-19 | vs SDN | 60 | L 0-1 | 25-35 | 5 | 10,067 | Jim Todd | Dan Spillner | Dan Spillner | Jim Todd | | 256 | 316 | -60 |
| 1974-06-20 | vs PIT | 61 | W 3-0 | 26-35 | 5 | 12,321 | Rick Reuschel | Dock Ellis | Rick Reuschel | Dock Ellis | | 259 | 316 | -57 |
| 1974-06-21 | vs PIT | 62 | W 3-2 | 27-35 | 4 | 11,625 | Steve Stone | Jim Rooker | Steve Stone | Jim Rooker | Oscar Zamora | 262 | 318 | -56 |
| 1974-06-22 | vs PIT | 63 | L 0-6 | 27-36 | 5 | 10,069 | Ken Frailing | Ken Brett | Ken Brett | Ken Frailing | | 262 | 324 | -62 |
| 1974-06-23 | vs PIT | 64 | W 7-3 | 28-36 | 4 | 24,855 | Bill Bonham | Bruce Kison | Bill Bonham | Dave Giusti | | 269 | 327 | -58 |
| 1974-06-24 | vs NYN | 65 | L 2-4 | 28-37 | 4 | 9,860 | Jim Todd | Jon Matlack | Bob Miller | Oscar Zamora | | 271 | 331 | -60 |
| 1974-06-25 | vs NYN | 66 | L 1-5 | 28-38 | 4 | 13,217 | Rick Reuschel | Jerry Koosman | Jerry Koosman | Rick Reuschel | | 272 | 336 | -64 |
| 1974-06-26 | vs NYN | 67 | L 4-5 | 28-39 | 5 | 15,275 | Steve Stone | Harry Parker | Jack Aker | Burt Hooton | | 276 | 341 | -65 |
| 1974-06-27 | @ MON | 68 | W 5-4 | 29-39 | 4 | 12,345 | Bill Bonham | Ernie McAnally | Bill Bonham | Ernie McAnally | Oscar Zamora | 281 | 345 | -64 |
| 1974-06-28 | @ MON | 69 | W 8-7 | 30-40 | 4 | 0 | Jim Todd | Mike Torrez | Ray Burris | Ernie McAnally | Bill Bonham | 289 | 352 | -63 |
| 1974-06-28 | @ MON | 70 | L 0-15 | 30-40 | 4 | 20,098 | Ken Frailing | Dennis Blair | Dennis Blair | Ken Frailing | | 289 | 367 | -78 |
| 1974-06-29 | @ MON | 71 | W 2-1 | 31-40 | 4 | 14,283 | Rick Reuschel | Steve Renko | Rick Reuschel | Steve Renko | | 291 | 368 | -77 |
| 1974-06-30 | @ MON | 72 | L 2-10 | 31-41 | 5 | 13,406 | Steve Stone | Steve Rogers | Steve Rogers | Steve Stone | | 293 | 378 | -85 |
| 1974-07-01 | @ MON | 73 | L 4-10 | 31-42 | 5 | 17,143 | Bill Bonham | Ernie McAnally | Ernie McAnally | Bill Bonham | | 297 | 388 | -91 |
| 1974-07-02 | @ SLN | 74 | W 4-3 | 32-42 | 5 | 26,088 | Jim Todd | Sonny Siebert | Jim Todd | Sonny Siebert | Oscar Zamora | 301 | 391 | -90 |
| 1974-07-03 | @ SLN | 75 | L 0-5 | 32-43 | 5 | 29,705 | Rick Reuschel | Lynn McGlothen | Lynn McGlothen | Rick Reuschel | | 301 | 396 | -95 |
| 1974-07-04 | @ SLN | 76 | W 3-2 | 33-43 | 5 | 28,350 | Steve Stone | John Curtis | Steve Stone | John Curtis | Oscar Zamora | 304 | 398 | -94 |
| 1974-07-05 | vs ATL | 77 | W 4-1 | 35-43 | 5 | 0 | Bill Bonham | Carl Morton | Bill Bonham | Carl Morton | | 308 | 399 | -91 |
| 1974-07-05 | vs ATL | 78 | W 3-2 | 35-43 | 5 | 29,076 | Ray Burris | Phil Niekro | Oscar Zamora | Max Leon | | 311 | 401 | -90 |
| 1974-07-06 | vs ATL | 79 | L 2-3 | 35-44 | 5 | 27,757 | Jim Todd | Roric Harrison | Lew Krausse | Oscar Zamora | Danny Frisella | 313 | 404 | -91 |
| 1974-07-07 | vs ATL | 80 | W 4-3 | 36-44 | 5 | 28,409 | Rick Reuschel | Buzz Capra | Rick Reuschel | Buzz Capra | Horacio Pina | 317 | 407 | -90 |
| 1974-07-09 | vs CIN | 81 | L 5-8 | 36-45 | 5 | 19,015 | Steve Stone | Jack Billingham | Jack Billingham | Steve Stone | Pedro Borbon | 322 | 415 | -93 |
| 1974-07-10 | vs CIN | 82 | W 11-3 | 37-45 | 4 | 16,450 | Bill Bonham | Fred Norman | Bill Bonham | Fred Norman | Oscar Zamora | 333 | 418 | -85 |
| 1974-07-11 | vs CIN | 83 | L 3-4 | 37-46 | 5 | 17,200 | Dave LaRoche | Clay Kirby | Pedro Borbon | Burt Hooton | | 336 | 422 | -86 |
| 1974-07-12 | @ HOU | 84 | L 4-9 | 37-47 | 4 | 16,946 | Rick Reuschel | Don Wilson | Don Wilson | Rick Reuschel | | 340 | 431 | -91 |
| 1974-07-13 | @ HOU | 85 | L 0-4 | 37-48 | 4 | 20,080 | Ray Burris | Claude Osteen | Claude Osteen | Ray Burris | | 340 | 435 | -95 |
| 1974-07-14 | @ HOU | 86 | L 6-7 | 37-49 | 6 | 17,985 | Bill Bonham | Tom Griffin | Jim York | Oscar Zamora | | 346 | 442 | -96 |
| 1974-07-15 | @ ATL | 87 | W 7-3 | 38-49 | 5 | 8,688 | Dave LaRoche | Carl Morton | Oscar Zamora | Joe Niekro | | 353 | 445 | -92 |
| 1974-07-16 | @ ATL | 88 | W 7-2 | 39-49 | 5 | 7,046 | Rick Reuschel | Roric Harrison | Rick Reuschel | Roric Harrison | | 360 | 447 | -87 |
| 1974-07-17 | @ ATL | 89 | L 2-7 | 39-50 | 5 | 7,142 | Ray Burris | Buzz Capra | Buzz Capra | Ray Burris | | 362 | 454 | -92 |
| 1974-07-18 | @ CIN | 90 | W 3-2 | 40-50 | 5 | 28,459 | Bill Bonham | Fred Norman | Bill Bonham | Fred Norman | Oscar Zamora | 365 | 456 | -91 |
| 1974-07-19 | @ CIN | 91 | L 1-4 | 40-51 | 5 | 42,430 | Dave LaRoche | Jack Billingham | Jack Billingham | Dave LaRoche | Pedro Borbon | 366 | 460 | -94 |
| 1974-07-20 | @ CIN | 92 | W 11-6 | 41-51 | 5 | 45,017 | Rick Reuschel | Clay Kirby | Oscar Zamora | Clay Carroll | | 377 | 466 | -89 |
| 1974-07-21 | @ CIN | 93 | L 2-8 | 41-52 | 5 | 34,031 | Burt Hooton | Don Gullett | Don Gullett | Burt Hooton | | 379 | 474 | -95 |
| 1974-07-25 | vs PHI | 94 | L 2-10 | 41-53 | 5 | 13,849 | Burt Hooton | Steve Carlton | Steve Carlton | Burt Hooton | | 381 | 484 | -103 |
| 1974-07-26 | vs PHI | 95 | W 10-7 | 42-53 | 5 | 14,701 | Rick Reuschel | Jim Lonborg | Rick Reuschel | Jim Lonborg | | 391 | 491 | -100 |
| 1974-07-27 | vs SLN | 96 | L 2-3 | 42-54 | 5 | 29,228 | Bill Bonham | Bob Forsch | Bob Forsch | Bill Bonham | | 393 | 494 | -101 |
| 1974-07-28 | vs SLN | 97 | L 4-5 | 42-55 | 6 | 30,425 | Steve Stone | Sonny Siebert | Al Hrabosky | Ken Frailing | Mike Garman | 397 | 499 | -102 |
| 1974-07-29 | vs SLN | 98 | L 4-11 | 42-56 | 6 | 18,689 | Burt Hooton | John Curtis | John Curtis | Burt Hooton | | 401 | 510 | -109 |
| 1974-07-30 | vs MON | 99 | L 3-4 | 42-57 | 6 | 12,000 | Rick Reuschel | Steve Renko | John Montague | Rick Reuschel | | 404 | 514 | -110 |
| 1974-07-31 | vs MON | 100 | L 4-7 | 42-59 | 6 | 0 | Bill Bonham | Mike Torrez | Chuck Taylor | Bill Bonham | | 408 | 521 | -113 |
| 1974-07-31 | vs MON | 101 | L 0-4 | 42-59 | 6 | 19,329 | Herb Hutson | Dennis Blair | Dennis Blair | Herb Hutson | | 408 | 525 | -117 |
| 1974-08-01 | @ NYN | 102 | W 7-4 | 44-59 | 6 | 0 | Steve Stone | Bob Apodaca | Burt Hooton | Tug McGraw | | 415 | 529 | -114 |
| 1974-08-01 | @ NYN | 103 | W 3-1 | 44-59 | 6 | 26,230 | Dave LaRoche | Ray Sadecki | Dave LaRoche | Ray Sadecki | Oscar Zamora | 418 | 530 | -112 |
| 1974-08-03 | @ PIT | 104 | W 4-3 | 45-59 | 6 | 9,316 | Rick Reuschel | Jerry Reuss | Rick Reuschel | Jerry Reuss | Dave LaRoche | 422 | 533 | -111 |
| 1974-08-04 | @ PIT | 105 | W 4-3 | 46-60 | 6 | 0 | Bill Bonham | Jim Rooker | Bill Bonham | Jim Rooker | | 426 | 536 | -110 |
| 1974-08-04 | @ PIT | 106 | L 1-7 | 46-60 | 6 | 23,536 | Herb Hutson | Bruce Kison | Bruce Kison | Herb Hutson | | 427 | 543 | -116 |
| 1974-08-06 | @ PHI | 107 | L 3-8 | 46-61 | 6 | 14,490 | Jim Todd | Steve Carlton | Steve Carlton | Jim Todd | | 430 | 551 | -121 |
| 1974-08-07 | @ PHI | 108 | L 2-3 | 46-62 | 6 | 11,284 | Rick Reuschel | Jim Lonborg | Gene Garber | Oscar Zamora | | 432 | 554 | -122 |
| 1974-08-08 | @ PHI | 109 | L 1-2 | 46-63 | 6 | 11,349 | Bill Bonham | Ron Schueler | Ron Schueler | Bill Bonham | Gene Garber | 433 | 556 | -123 |
| 1974-08-09 | vs SFN | 110 | L 0-3 | 46-64 | 6 | 10,777 | Steve Stone | Jim Barr | Jim Barr | Steve Stone | | 433 | 559 | -126 |
| 1974-08-11 | vs SFN | 111 | L 3-5 | 46-66 | 6 | 0 | Rick Reuschel | Mike Caldwell | Mike Caldwell | Rick Reuschel | | 436 | 564 | -128 |
| 1974-08-11 | vs SFN | 112 | L 4-6 | 46-66 | 6 | 18,554 | Ken Frailing | John D'Acquisto | Elias Sosa | Oscar Zamora | | 440 | 570 | -130 |
| 1974-08-13 | vs HOU | 113 | L 1-3 | 46-67 | 6 | 11,947 | Bill Bonham | Dave Roberts | Dave Roberts | Bill Bonham | | 441 | 573 | -132 |
| 1974-08-14 | vs HOU | 114 | W 6-5 | 47-67 | 6 | 10,987 | Steve Stone | Don Wilson | Steve Stone | Don Wilson | Jim Todd | 447 | 578 | -131 |
| 1974-08-15 | vs HOU | 115 | W 5-3 | 48-67 | 6 | 9,151 | Rick Reuschel | J.R. Richard | Jim Todd | Ken Forsch | | 452 | 581 | -129 |
| 1974-08-16 | vs SDN | 116 | W 4-1 | 49-67 | 6 | 9,075 | Jim Kremmel | Dave Freisleben | Tom Dettore | Dave Freisleben | Jim Todd | 456 | 582 | -126 |
| 1974-08-17 | vs SDN | 117 | L 3-4 | 49-68 | 6 | 14,323 | Bill Bonham | Dan Spillner | Larry Hardy | Oscar Zamora | | 459 | 586 | -127 |
| 1974-08-18 | vs SDN | 118 | W 14-6 | 50-68 | 6 | 17,906 | Steve Stone | Bill Greif | Steve Stone | Bill Greif | | 473 | 592 | -119 |
| 1974-08-19 | vs LAN | 119 | L 7-8 | 50-69 | 6 | 15,261 | Rick Reuschel | Doug Rau | Mike Marshall | Oscar Zamora | | 480 | 600 | -120 |
| 1974-08-20 | vs LAN | 120 | L 8-18 | 50-70 | 6 | 19,736 | Tom Dettore | Don Sutton | Don Sutton | Tom Dettore | | 488 | 618 | -130 |
| 1974-08-21 | vs LAN | 121 | L 5-7 | 50-71 | 6 | 18,262 | Bill Bonham | Andy Messersmith | Andy Messersmith | Bill Bonham | Mike Marshall | 493 | 625 | -132 |
| 1974-08-23 | @ SFN | 122 | W 1-0 | 50-72 | 6 | 3,099 | Rick Reuschel | Jim Barr | Rick Reuschel | Jim Barr | | 494 | 625 | -131 |
| 1974-08-24 | @ SFN | 123 | W 2-1 | 51-72 | 6 | 7,155 | Steve Stone | Ron Bryant | Steve Stone | Ron Bryant | Burt Hooton | 496 | 626 | -130 |
| 1974-08-25 | @ SFN | 124 | L 3-4 | 51-73 | 6 | 5,257 | Bill Bonham | Mike Caldwell | Elias Sosa | Oscar Zamora | | 499 | 630 | -131 |
| 1974-08-27 | @ LAN | 125 | L 5-12 | 51-74 | 6 | 25,212 | Rick Reuschel | Doug Rau | Charlie Hough | Rick Reuschel | | 504 | 642 | -138 |
| 1974-08-28 | @ LAN | 126 | L 6-7 | 51-75 | 6 | 27,053 | Burt Hooton | Don Sutton | Mike Marshall | Oscar Zamora | | 510 | 649 | -139 |
| 1974-08-29 | @ LAN | 127 | L 1-3 | 51-76 | 6 | 22,262 | Bill Bonham | Andy Messersmith | Andy Messersmith | Bill Bonham | | 511 | 652 | -141 |
| 1974-08-30 | @ SDN | 128 | W 5-1 | 53-76 | 6 | 0 | Tom Dettore | Dave Freisleben | Ken Frailing | Dave Freisleben | | 516 | 653 | -137 |
| 1974-08-30 | @ SDN | 129 | W 4-3 | 53-76 | 6 | 8,773 | Steve Stone | Lowell Palmer | Dave LaRoche | Mike Johnson | Jim Todd | 520 | 656 | -136 |
| 1974-09-01 | @ SDN | 130 | W 4-1 | 54-76 | 6 | 7,128 | Rick Reuschel | Dan Spillner | Rick Reuschel | Dan Spillner | Oscar Zamora | 524 | 657 | -133 |
| 1974-09-03 | vs NYN | 131 | L 0-2 | 54-78 | 6 | 0 | Bill Bonham | Jon Matlack | Jon Matlack | Bill Bonham | | 524 | 659 | -135 |
| 1974-09-03 | vs NYN | 132 | L 4-11 | 54-78 | 6 | 3,731 | Tom Dettore | Tom Seaver | Tom Seaver | Tom Dettore | | 528 | 670 | -142 |
| 1974-09-04 | vs NYN | 133 | L 2-4 | 54-79 | 6 | 1,953 | Steve Stone | Ray Sadecki | Ray Sadecki | Steve Stone | Bob Apodaca | 530 | 674 | -144 |
| 1974-09-05 | vs PHI | 134 | L 5-6 | 54-80 | 6 | 1,943 | Rick Reuschel | Jim Lonborg | Ron Schueler | Dave LaRoche | Larry Christenson | 535 | 680 | -145 |
| 1974-09-06 | vs PHI | 135 | L 3-4 | 54-81 | 6 | 2,104 | Burt Hooton | Dick Ruthven | Dick Ruthven | Burt Hooton | | 538 | 684 | -146 |
| 1974-09-07 | vs PHI | 136 | W 3-0 | 55-81 | 6 | 10,632 | Bill Bonham | Steve Carlton | Bill Bonham | Steve Carlton | | 541 | 684 | -143 |
| 1974-09-08 | vs PHI | 137 | L 10-11 | 55-82 | 6 | 14,564 | Tom Dettore | Wayne Twitchell | Gene Garber | Tom Dettore | | 551 | 695 | -144 |
| 1974-09-09 | vs PIT | 138 | W 9-4 | 56-82 | 6 | 2,918 | Steve Stone | Larry Demery | Steve Stone | Larry Demery | Dave LaRoche | 560 | 699 | -139 |
| 1974-09-10 | vs PIT | 139 | L 4-12 | 56-83 | 6 | 4,843 | Rick Reuschel | Ken Brett | Ken Brett | Rick Reuschel | | 564 | 711 | -147 |
| 1974-09-11 | @ MON | 140 | L 1-6 | 56-85 | 6 | 0 | Bill Bonham | Steve Renko | Steve Renko | Bill Bonham | Dale Murray | 565 | 717 | -152 |
| 1974-09-11 | @ MON | 141 | L 4-13 | 56-85 | 6 | 7,462 | Ray Burris | Tom Walker | Tom Walker | Ray Burris | Chuck Taylor | 569 | 730 | -161 |
| 1974-09-12 | @ MON | 142 | L 1-2 | 56-86 | 6 | 5,163 | Tom Dettore | Mike Torrez | Mike Torrez | Tom Dettore | Dale Murray | 570 | 732 | -162 |
| 1974-09-13 | @ NYN | 143 | L 0-6 | 57-87 | 6 | 0 | Rick Reuschel | Tom Seaver | Tom Seaver | Rick Reuschel | | 570 | 738 | -168 |
| 1974-09-13 | @ NYN | 144 | W 4-3 | 57-87 | 6 | 19,009 | Steve Stone | Nino Espinosa | Jim Todd | Bob Apodaca | | 574 | 741 | -167 |
| 1974-09-14 | @ NYN | 145 | W 12-0 | 58-87 | 6 | 14,761 | Burt Hooton | Ray Sadecki | Burt Hooton | Ray Sadecki | | 586 | 741 | -155 |
| 1974-09-15 | @ NYN | 146 | W 5-4 | 59-87 | 6 | 17,288 | Bill Bonham | Hank Webb | Dave LaRoche | Tug McGraw | Oscar Zamora | 591 | 745 | -154 |
| 1974-09-17 | @ PHI | 147 | W 4-2 | 60-87 | 6 | 10,152 | Tom Dettore | Wayne Twitchell | Tom Dettore | Wayne Twitchell | Dave LaRoche | 595 | 747 | -152 |
| 1974-09-18 | @ PHI | 148 | W 5-2 | 61-87 | 6 | 8,133 | Rick Reuschel | Jim Lonborg | Steve Stone | Jim Lonborg | Ken Frailing | 600 | 749 | -149 |
| 1974-09-19 | @ PHI | 149 | W 7-4 | 62-87 | 6 | 8,672 | Burt Hooton | Dick Ruthven | Burt Hooton | Ron Schueler | Dave LaRoche | 607 | 753 | -146 |
| 1974-09-20 | @ SLN | 150 | L 2-5 | 62-88 | 6 | 25,335 | Bill Bonham | Bob Forsch | Bob Forsch | Bill Bonham | Mike Garman | 609 | 758 | -149 |
| 1974-09-21 | @ SLN | 151 | W 19-4 | 63-88 | 6 | 31,980 | Tom Dettore | Claude Osteen | Tom Dettore | Claude Osteen | | 628 | 762 | -134 |
| 1974-09-22 | @ SLN | 152 | L 5-6 | 63-89 | 6 | 43,267 | Steve Stone | Bob Gibson | Al Hrabosky | Dave LaRoche | | 633 | 768 | -135 |
| 1974-09-24 | vs MON | 153 | W 6-4 | 64-90 | 6 | 0 | Burt Hooton | Steve Renko | Burt Hooton | Steve Renko | Oscar Zamora | 639 | 772 | -133 |
| 1974-09-24 | vs MON | 154 | L 2-11 | 64-90 | 6 | 1,751 | Ray Burris | Don Carrithers | Don Carrithers | Ray Burris | Dale Murray | 641 | 783 | -142 |
| 1974-09-25 | vs MON | 155 | L 1-7 | 64-92 | 6 | 0 | Bill Bonham | Tom Walker | Tom Walker | Bill Bonham | | 642 | 790 | -148 |
| 1974-09-25 | vs MON | 156 | L 2-3 | 64-92 | 6 | 2,537 | Jim Kremmel | Steve Rogers | Steve Rogers | Jim Kremmel | Dale Murray | 644 | 793 | -149 |
| 1974-09-27 | vs SLN | 157 | L 4-10 | 64-93 | 6 | 4,904 | Tom Dettore | Bob Gibson | Bob Gibson | Tom Dettore | | 648 | 803 | -155 |
| 1974-09-28 | vs SLN | 158 | W 8-3 | 65-93 | 6 | 13,867 | Rick Reuschel | Lynn McGlothen | Dave LaRoche | Lynn McGlothen | | 656 | 806 | -150 |
| 1974-09-29 | vs SLN | 159 | L 3-7 | 65-94 | 6 | 17,722 | Steve Stone | John Curtis | John Curtis | Steve Stone | | 659 | 813 | -154 |
| 1974-09-30 | @ PIT | 160 | L 1-2 | 65-95 | 6 | 10,482 | Bill Bonham | Bruce Kison | Bruce Kison | Bill Bonham | | 660 | 815 | -155 |
| 1974-10-01 | @ PIT | 161 | L 5-6 | 65-96 | 6 | 13,801 | Tom Dettore | Jerry Reuss | Dave Giusti | Dave LaRoche | | 665 | 821 | -156 |
| 1974-10-02 | @ PIT | 162 | L 4-5 | 65-97 | 6 | 22,725 | Rick Reuschel | Jim Rooker | Ramon Hernandez | Ken Frailing | | 669 | 826 | -157 |