| 1974-04-05 | @ MIL | 1 | W 9-8 | 1-0 | 2 | 32,761 | Luis Tiant | Jim Colborn | Diego Segui | Kevin Kobel | | 9 | 8 | 1 |
| 1974-04-06 | @ MIL | 2 | L 4-5 | 1-1 | 3 | 11,458 | Bill Lee | Jim Slaton | Jim Slaton | Bill Lee | Eduardo Rodriguez | 13 | 13 | 0 |
| 1974-04-11 | vs BAL | 3 | L 6-7 | 1-2 | 5 | 23,441 | Luis Tiant | Jim Palmer | Bob Reynolds | Diego Segui | | 19 | 20 | -1 |
| 1974-04-12 | vs DET | 4 | W 6-3 | 2-2 | 4 | 8,481 | Bill Lee | Lerrin LaGrow | Bill Lee | Lerrin LaGrow | | 25 | 23 | 2 |
| 1974-04-13 | vs DET | 5 | W 8-1 | 3-2 | 2 | 8,159 | Rick Wise | Bill Slayback | Rick Wise | Bill Slayback | | 33 | 24 | 9 |
| 1974-04-14 | vs DET | 6 | W 7-5 | 4-2 | 1 | 11,274 | Juan Marichal | Mickey Lolich | Dick Drago | Mickey Lolich | Diego Segui | 40 | 29 | 11 |
| 1974-04-15 | vs DET | 7 | L 0-1 | 4-3 | 2 | 23,498 | Reggie Cleveland | Joe Coleman | Joe Coleman | Reggie Cleveland | | 40 | 30 | 10 |
| 1974-04-16 | @ NYA | 8 | L 1-2 | 4-4 | 4 | 10,480 | Luis Tiant | Mel Stottlemyre | Mel Stottlemyre | Luis Tiant | | 41 | 32 | 9 |
| 1974-04-17 | @ NYA | 9 | W 4-3 | 5-4 | 3 | 11,517 | Bill Lee | Pat Dobson | Bill Lee | Pat Dobson | | 45 | 35 | 10 |
| 1974-04-18 | @ NYA | 10 | L 1-6 | 5-5 | 4 | 10,272 | Rick Wise | Doc Medich | Doc Medich | Rick Wise | | 46 | 41 | 5 |
| 1974-04-19 | vs CLE | 11 | W 6-3 | 6-5 | 3 | 9,098 | Reggie Cleveland | Dick Tidrow | Reggie Cleveland | Dick Tidrow | Dick Drago | 52 | 44 | 8 |
| 1974-04-20 | vs CLE | 12 | W 5-4 | 7-5 | 2 | 11,667 | Luis Tiant | Bob Johnson | Luis Tiant | Bob Johnson | | 57 | 48 | 9 |
| 1974-04-21 | vs CLE | 13 | W 6-5 | 8-5 | 2 | 14,954 | Bill Lee | Jim Perry | Diego Segui | Cecil Upshaw | | 63 | 53 | 10 |
| 1974-04-22 | vs KCA | 14 | W 4-1 | 9-5 | 1 | 11,927 | Rick Wise | Nelson Briles | Rick Wise | Nelson Briles | Diego Segui | 67 | 54 | 13 |
| 1974-04-23 | vs KCA | 15 | L 2-5 | 9-6 | 1 | 5,388 | Dick Drago | Al Fitzmorris | Al Fitzmorris | Dick Drago | | 69 | 59 | 10 |
| 1974-04-24 | @ TEX | 16 | L 1-3 | 9-7 | 3 | 15,707 | Reggie Cleveland | Fergie Jenkins | Fergie Jenkins | Reggie Cleveland | | 70 | 62 | 8 |
| 1974-04-25 | @ TEX | 17 | L 0-4 | 9-8 | 4 | 15,100 | Luis Tiant | Jim Bibby | Jim Bibby | Luis Tiant | | 70 | 66 | 4 |
| 1974-04-26 | @ KCA | 18 | L 2-4 | 9-9 | 4 | 13,537 | Bill Lee | Steve Busby | Steve Busby | Bill Lee | | 72 | 70 | 2 |
| 1974-04-27 | @ KCA | 19 | L 3-10 | 9-10 | 4 | 11,841 | Juan Marichal | Al Fitzmorris | Al Fitzmorris | Juan Marichal | | 75 | 80 | -5 |
| 1974-04-28 | @ KCA | 20 | W 5-4 | 10-10 | 4 | 13,306 | Roger Moret | Marty Pattin | Dick Drago | Doug Bird | | 80 | 84 | -4 |
| 1974-04-29 | vs CAL | 21 | L 2-7 | 10-11 | 4 | 9,674 | Luis Tiant | Bill Singer | Bill Singer | Luis Tiant | | 82 | 91 | -9 |
| 1974-04-30 | vs CAL | 22 | L 6-16 | 10-12 | 6 | 7,395 | Reggie Cleveland | Nolan Ryan | Nolan Ryan | Reggie Cleveland | | 88 | 107 | -19 |
| 1974-05-01 | vs CAL | 23 | L 2-4 | 10-13 | 6 | 6,534 | Bill Lee | Bill Stoneman | Bill Stoneman | Bill Lee | Rudy May | 90 | 111 | -21 |
| 1974-05-04 | vs TEX | 24 | L 0-1 | 10-14 | 6 | 9,984 | Rick Wise | Fergie Jenkins | Fergie Jenkins | Rick Wise | | 90 | 112 | -22 |
| 1974-05-05 | vs TEX | 25 | L 3-5 | 11-15 | 6 | 0 | Luis Tiant | Steve Hargan | Steve Hargan | Luis Tiant | Steve Foucault | 93 | 117 | -24 |
| 1974-05-05 | vs TEX | 26 | W 10-8 | 11-15 | 6 | 17,190 | Juan Marichal | Jim Bibby | Juan Marichal | Jim Bibby | | 103 | 125 | -22 |
| 1974-05-08 | vs NYA | 27 | W 4-0 | 12-15 | 6 | 13,985 | Bill Lee | Mel Stottlemyre | Bill Lee | Mel Stottlemyre | | 107 | 125 | -18 |
| 1974-05-09 | vs NYA | 28 | W 2-0 | 13-15 | 5 | 12,193 | Luis Tiant | Pat Dobson | Luis Tiant | Pat Dobson | | 109 | 125 | -16 |
| 1974-05-10 | @ DET | 29 | L 5-6 | 13-16 | 5 | 16,322 | Reggie Cleveland | Mickey Lolich | John Hiller | Diego Segui | | 114 | 131 | -17 |
| 1974-05-11 | @ DET | 30 | W 8-5 | 14-16 | 5 | 10,487 | Roger Moret | Joe Coleman | Lance Clemons | John Hiller | | 122 | 136 | -14 |
| 1974-05-12 | @ DET | 31 | W 4-3 | 15-16 | 5 | 23,686 | Bill Lee | Lerrin LaGrow | Bill Lee | John Hiller | Diego Segui | 126 | 139 | -13 |
| 1974-05-13 | @ CLE | 32 | L 1-4 | 15-17 | 6 | 4,234 | Luis Tiant | Jim Perry | Jim Perry | Luis Tiant | Tom Buskey | 127 | 143 | -16 |
| 1974-05-14 | @ CLE | 33 | L 2-6 | 15-18 | 6 | 7,150 | Reggie Cleveland | Gaylord Perry | Gaylord Perry | Reggie Cleveland | | 129 | 149 | -20 |
| 1974-05-15 | @ CLE | 34 | W 7-4 | 16-18 | 6 | 7,072 | Juan Marichal | Steve Kline | Juan Marichal | Steve Kline | | 136 | 153 | -17 |
| 1974-05-17 | @ BAL | 35 | L 0-6 | 16-19 | 6 | 13,178 | Bill Lee | Mike Cuellar | Mike Cuellar | Bill Lee | | 136 | 159 | -23 |
| 1974-05-18 | @ BAL | 36 | W 10-2 | 17-19 | 6 | 6,081 | Luis Tiant | Ross Grimsley | Luis Tiant | Ross Grimsley | | 146 | 161 | -15 |
| 1974-05-19 | @ BAL | 37 | W 11-2 | 19-19 | 4 | 0 | Reggie Cleveland | Dave McNally | Reggie Cleveland | Dave McNally | | 157 | 163 | -6 |
| 1974-05-19 | @ BAL | 38 | W 6-4 | 19-19 | 4 | 24,839 | Dick Drago | Doyle Alexander | Dick Drago | Doyle Alexander | | 163 | 167 | -4 |
| 1974-05-21 | vs NYA | 39 | W 14-6 | 20-19 | 2 | 15,208 | Bill Lee | Dick Tidrow | Bill Lee | Dick Tidrow | | 177 | 173 | 4 |
| 1974-05-22 | vs NYA | 40 | W 6-3 | 21-19 | 2 | 16,466 | Luis Tiant | Doc Medich | Luis Tiant | Doc Medich | | 183 | 176 | 7 |
| 1974-05-24 | vs MIL | 41 | W 5-3 | 22-19 | 1 | 15,951 | Rick Wise | Bill Champion | Dick Drago | Bill Champion | | 188 | 179 | 9 |
| 1974-05-25 | vs MIL | 42 | L 2-9 | 22-20 | 3 | 19,827 | Reggie Cleveland | Clyde Wright | Clyde Wright | Reggie Cleveland | | 190 | 188 | 2 |
| 1974-05-26 | vs MIL | 43 | W 4-1 | 23-20 | 1 | 14,412 | Bill Lee | Ed Sprague | Bill Lee | Ed Sprague | | 194 | 189 | 5 |
| 1974-05-27 | vs MIN | 44 | W 3-2 | 24-20 | 1 | 11,977 | Luis Tiant | Ray Corbin | Luis Tiant | Tom Burgmeier | | 197 | 191 | 6 |
| 1974-05-28 | vs MIN | 45 | W 9-5 | 25-20 | 1 | 10,811 | Reggie Cleveland | Bert Blyleven | Reggie Cleveland | Bert Blyleven | | 206 | 196 | 10 |
| 1974-05-29 | vs MIN | 46 | L 4-5 | 25-21 | 2 | 9,429 | Dick Drago | Dave Goltz | Tom Burgmeier | Diego Segui | | 210 | 201 | 9 |
| 1974-05-31 | vs CHA | 47 | L 2-3 | 25-22 | 2 | 21,398 | Bill Lee | Wilbur Wood | Wilbur Wood | Bill Lee | Terry Forster | 212 | 204 | 8 |
| 1974-06-01 | vs CHA | 48 | W 8-0 | 26-22 | 1 | 20,404 | Luis Tiant | Stan Bahnsen | Luis Tiant | Stan Bahnsen | | 220 | 204 | 16 |
| 1974-06-02 | vs CHA | 49 | W 9-7 | 27-22 | 1 | 22,219 | Reggie Cleveland | Jim Kaat | Reggie Cleveland | Jim Kaat | | 229 | 211 | 18 |
| 1974-06-03 | @ MIN | 50 | L 4-5 | 27-23 | 1 | 5,882 | Dick Drago | Ray Corbin | Bill Hands | Diego Segui | | 233 | 216 | 17 |
| 1974-06-04 | @ MIN | 51 | W 4-3 | 28-23 | 1 | 5,147 | Bill Lee | Joe Decker | Diego Segui | Bill Campbell | Roger Moret | 237 | 219 | 18 |
| 1974-06-05 | @ MIN | 52 | W 5-3 | 29-23 | 1 | 5,183 | Luis Tiant | Dave Goltz | Luis Tiant | Dave Goltz | | 242 | 222 | 20 |
| 1974-06-07 | @ CHA | 53 | L 6-8 | 29-24 | 1 | 15,173 | Reggie Cleveland | Joe Henderson | Jim Kaat | Roger Moret | Cy Acosta | 248 | 230 | 18 |
| 1974-06-08 | @ CHA | 54 | L 6-13 | 29-25 | 2 | 42,096 | Dick Drago | Wilbur Wood | Wilbur Wood | Bob Veale | | 254 | 243 | 11 |
| 1974-06-09 | @ CHA | 55 | W 10-6 | 30-25 | 1 | 16,678 | Bill Lee | Skip Pitlock | Bill Lee | Skip Pitlock | | 264 | 249 | 15 |
| 1974-06-10 | vs OAK | 56 | W 4-1 | 31-25 | 1 | 28,537 | Luis Tiant | Vida Blue | Luis Tiant | Vida Blue | | 268 | 250 | 18 |
| 1974-06-11 | vs OAK | 57 | W 10-9 | 32-25 | 1 | 24,762 | Reggie Cleveland | Catfish Hunter | Diego Segui | Catfish Hunter | Bob Veale | 278 | 259 | 19 |
| 1974-06-12 | vs OAK | 58 | W 5-3 | 33-25 | 1 | 27,079 | Dick Drago | Dave Hamilton | Dick Drago | Darold Knowles | | 283 | 262 | 21 |
| 1974-06-14 | @ CAL | 59 | L 3-4 | 33-26 | 1 | 11,083 | Luis Tiant | Nolan Ryan | Barry Raziano | Luis Tiant | | 286 | 266 | 20 |
| 1974-06-15 | @ CAL | 60 | W 5-3 | 34-26 | 1 | 26,401 | Bill Lee | Bill Stoneman | Bill Lee | Bill Stoneman | Diego Segui | 291 | 269 | 22 |
| 1974-06-16 | @ CAL | 61 | W 7-4 | 35-26 | 1 | 11,828 | Reggie Cleveland | Dick Lange | Reggie Cleveland | Barry Raziano | | 298 | 273 | 25 |
| 1974-06-17 | @ OAK | 62 | L 2-3 | 35-27 | 1 | 37,095 | Dick Drago | Dave Hamilton | Rollie Fingers | Dick Drago | | 300 | 276 | 24 |
| 1974-06-18 | @ OAK | 63 | W 6-1 | 36-27 | 1 | 3,033 | Roger Moret | Ken Holtzman | Roger Moret | Ken Holtzman | | 306 | 277 | 29 |
| 1974-06-19 | @ OAK | 64 | W 2-1 | 37-27 | 1 | 7,281 | Luis Tiant | Vida Blue | Luis Tiant | Vida Blue | Diego Segui | 308 | 278 | 30 |
| 1974-06-22 | vs CLE | 65 | L 0-11 | 38-28 | 1 | 26,936 | Bill Lee | Gaylord Perry | Gaylord Perry | Bill Lee | | 308 | 289 | 19 |
| 1974-06-22 | vs CLE | 66 | W 8-3 | 38-28 | 1 | 18,623 | Reggie Cleveland | Jim Perry | Reggie Cleveland | Jim Perry | Roger Moret | 316 | 292 | 24 |
| 1974-06-23 | vs CLE | 67 | W 8-0 | 39-28 | 1 | 21,496 | Rick Wise | Steve Kline | Rick Wise | Steve Kline | Dick Drago | 324 | 292 | 32 |
| 1974-06-24 | vs MIL | 68 | W 9-0 | 40-28 | 1 | 26,562 | Luis Tiant | Jim Colborn | Luis Tiant | Jim Colborn | | 333 | 292 | 41 |
| 1974-06-26 | vs MIL | 69 | L 1-7 | 40-29 | 1 | 17,826 | Bill Lee | Ed Sprague | Ed Sprague | Bill Lee | | 334 | 299 | 35 |
| 1974-06-27 | @ CLE | 70 | L 1-2 | 40-30 | 1 | 13,426 | Roger Moret | Jim Perry | Jim Perry | Roger Moret | Tom Buskey | 335 | 301 | 34 |
| 1974-06-28 | @ CLE | 71 | L 1-2 | 40-31 | 1 | 33,020 | Dick Drago | Gaylord Perry | Gaylord Perry | Dick Drago | | 336 | 303 | 33 |
| 1974-06-29 | @ CLE | 72 | W 12-2 | 41-31 | 1 | 10,220 | Luis Tiant | Fritz Peterson | Luis Tiant | Fritz Peterson | | 348 | 305 | 43 |
| 1974-06-30 | @ CLE | 73 | L 2-9 | 41-32 | 1 | 14,974 | Rick Wise | Steve Arlin | Steve Arlin | Rick Wise | | 350 | 314 | 36 |
| 1974-07-01 | @ BAL | 74 | W 6-4 | 42-32 | 1 | 15,696 | Bill Lee | Doyle Alexander | Bill Lee | Doyle Alexander | Diego Segui | 356 | 318 | 38 |
| 1974-07-02 | @ BAL | 75 | W 9-6 | 43-32 | 1 | 15,316 | Roger Moret | Ross Grimsley | Diego Segui | Dave Johnson | | 365 | 324 | 41 |
| 1974-07-03 | vs BAL | 76 | L 2-9 | 43-34 | 2 | 0 | Dick Drago | Dave McNally | Doyle Alexander | Dick Drago | | 367 | 333 | 34 |
| 1974-07-03 | vs BAL | 77 | L 4-6 | 43-34 | 2 | 27,730 | Reggie Cleveland | Wayne Garland | Wayne Garland | Reggie Cleveland | Dave McNally | 371 | 339 | 32 |
| 1974-07-04 | vs BAL | 78 | L 6-10 | 43-35 | 2 | 13,622 | Luis Tiant | Jesse Jefferson | Jesse Jefferson | Luis Tiant | | 377 | 349 | 28 |
| 1974-07-06 | vs KCA | 79 | L 3-5 | 43-36 | 2 | 23,331 | Rick Wise | Nelson Briles | Nelson Briles | Rick Wise | Al Fitzmorris | 380 | 354 | 26 |
| 1974-07-07 | vs KCA | 80 | L 9-11 | 44-37 | 2 | 0 | Bill Lee | Bruce Dal Canton | Joe Hoerner | Don Newhauser | | 389 | 365 | 24 |
| 1974-07-07 | vs KCA | 81 | W 5-3 | 44-37 | 2 | 21,146 | Roger Moret | Lindy McDaniel | Roger Moret | Marty Pattin | | 394 | 368 | 26 |
| 1974-07-08 | vs KCA | 82 | L 0-5 | 44-38 | 3 | 19,012 | Dick Drago | Steve Busby | Steve Busby | Dick Drago | | 394 | 373 | 21 |
| 1974-07-09 | vs TEX | 83 | W 2-1 | 45-38 | 3 | 15,051 | Luis Tiant | Jim Bibby | Luis Tiant | Jim Bibby | | 396 | 374 | 22 |
| 1974-07-10 | vs TEX | 84 | W 3-1 | 46-38 | 3 | 17,190 | Reggie Cleveland | David Clyde | Reggie Cleveland | David Clyde | | 399 | 375 | 24 |
| 1974-07-11 | vs TEX | 85 | W 12-3 | 47-38 | 2 | 25,915 | Bill Lee | Steve Hargan | Bill Lee | Steve Hargan | | 411 | 378 | 33 |
| 1974-07-12 | vs CAL | 86 | L 0-7 | 47-39 | 2 | 24,821 | Roger Moret | Ed Figueroa | Ed Figueroa | Roger Moret | | 411 | 385 | 26 |
| 1974-07-13 | vs CAL | 87 | L 1-12 | 47-40 | 3 | 23,862 | Dick Drago | Andy Hassler | Andy Hassler | Dick Drago | | 412 | 397 | 15 |
| 1974-07-14 | vs CAL | 88 | W 3-0 | 48-40 | 2 | 17,199 | Luis Tiant | Dick Lange | Luis Tiant | Dick Lange | | 415 | 397 | 18 |
| 1974-07-15 | @ KCA | 89 | L 2-3 | 48-41 | 2 | 13,380 | Reggie Cleveland | Nelson Briles | Nelson Briles | Reggie Cleveland | Doug Bird | 417 | 400 | 17 |
| 1974-07-16 | @ KCA | 90 | L 4-5 | 48-42 | 2 | 16,852 | Bill Lee | Steve Busby | Steve Busby | Bill Lee | | 421 | 405 | 16 |
| 1974-07-17 | @ KCA | 91 | W 6-3 | 49-42 | 1 | 15,644 | Roger Moret | Marty Pattin | Roger Moret | Marty Pattin | | 427 | 408 | 19 |
| 1974-07-18 | @ TEX | 92 | L 1-2 | 49-43 | 1 | 12,350 | Dick Drago | Fergie Jenkins | Fergie Jenkins | Dick Drago | | 428 | 410 | 18 |
| 1974-07-19 | @ TEX | 93 | W 3-1 | 50-43 | 1 | 22,387 | Luis Tiant | Jackie Brown | Luis Tiant | Jackie Brown | | 431 | 411 | 20 |
| 1974-07-20 | @ TEX | 94 | L 6-8 | 50-44 | 2 | 20,824 | Reggie Cleveland | Jim Bibby | Jim Bibby | Reggie Cleveland | | 437 | 419 | 18 |
| 1974-07-21 | @ TEX | 95 | L 1-2 | 50-45 | 2 | 11,770 | Bill Lee | Steve Hargan | Steve Hargan | Bill Lee | Steve Foucault | 438 | 421 | 17 |
| 1974-07-25 | @ DET | 96 | W 12-4 | 51-45 | 2 | 17,005 | Roger Moret | Mickey Lolich | Roger Moret | Mickey Lolich | Dick Drago | 450 | 425 | 25 |
| 1974-07-26 | @ DET | 97 | L 0-1 | 51-46 | 2 | 26,922 | Reggie Cleveland | Joe Coleman | Joe Coleman | Reggie Cleveland | | 450 | 426 | 24 |
| 1974-07-27 | vs NYA | 98 | W 5-4 | 52-46 | 2 | 34,834 | Luis Tiant | Dick Tidrow | Luis Tiant | Sparky Lyle | | 455 | 430 | 25 |
| 1974-07-28 | vs NYA | 99 | W 8-3 | 53-46 | 1 | 33,718 | Bill Lee | Dave Pagan | Bill Lee | Dave Pagan | | 463 | 433 | 30 |
| 1974-07-29 | vs NYA | 100 | W 2-1 | 54-46 | 1 | 30,889 | Roger Moret | Sam McDowell | Roger Moret | Sparky Lyle | | 465 | 434 | 31 |
| 1974-07-30 | vs DET | 101 | L 5-7 | 54-47 | 1 | 21,456 | Reggie Cleveland | Joe Coleman | John Hiller | Reggie Cleveland | | 470 | 441 | 29 |
| 1974-07-31 | vs DET | 102 | W 5-4 | 55-47 | 1 | 24,935 | Luis Tiant | Lerrin LaGrow | Luis Tiant | Lerrin LaGrow | | 475 | 445 | 30 |
| 1974-08-01 | vs BAL | 103 | W 11-3 | 56-47 | 1 | 27,596 | Bill Lee | Wayne Garland | Bill Lee | Wayne Garland | | 486 | 448 | 38 |
| 1974-08-02 | vs BAL | 104 | W 7-5 | 57-47 | 1 | 25,046 | Rick Wise | Jesse Jefferson | Juan Marichal | Doyle Alexander | | 493 | 453 | 40 |
| 1974-08-03 | @ NYA | 105 | L 2-6 | 57-48 | 1 | 51,906 | Roger Moret | Pat Dobson | Pat Dobson | Roger Moret | | 495 | 459 | 36 |
| 1974-08-04 | @ NYA | 106 | W 7-3 | 58-48 | 1 | 21,147 | Luis Tiant | Doc Medich | Luis Tiant | Doc Medich | | 502 | 462 | 40 |
| 1974-08-05 | @ NYA | 107 | L 0-8 | 58-49 | 1 | 21,147 | Bill Lee | Rudy May | Rudy May | Bill Lee | | 502 | 470 | 32 |
| 1974-08-06 | @ MIL | 108 | W 6-3 | 60-49 | 1 | 0 | Reggie Cleveland | Jim Slaton | Reggie Cleveland | Jim Slaton | Diego Segui | 508 | 473 | 35 |
| 1974-08-06 | @ MIL | 109 | W 6-0 | 60-49 | 1 | 22,756 | Juan Marichal | Clyde Wright | Juan Marichal | Clyde Wright | | 514 | 473 | 41 |
| 1974-08-07 | @ MIL | 110 | W 1-0 | 61-49 | 1 | 14,956 | Roger Moret | Jim Colborn | Roger Moret | Jim Colborn | Bob Veale | 515 | 473 | 42 |
| 1974-08-08 | @ MIL | 111 | L 3-5 | 61-50 | 1 | 22,339 | Luis Tiant | Bill Champion | Bill Champion | Luis Tiant | | 518 | 478 | 40 |
| 1974-08-09 | @ OAK | 112 | W 6-2 | 62-50 | 1 | 12,214 | Bill Lee | Ken Holtzman | Bill Lee | Ken Holtzman | | 524 | 480 | 44 |
| 1974-08-10 | @ OAK | 113 | L 3-5 | 62-51 | 1 | 11,414 | Reggie Cleveland | Vida Blue | Vida Blue | Reggie Cleveland | | 527 | 485 | 42 |
| 1974-08-11 | @ OAK | 114 | W 2-1 | 63-51 | 1 | 14,291 | Juan Marichal | Glenn Abbott | Juan Marichal | Glenn Abbott | | 529 | 486 | 43 |
| 1974-08-12 | @ CAL | 115 | L 2-4 | 63-52 | 1 | 9,345 | Roger Moret | Nolan Ryan | Nolan Ryan | Roger Moret | | 531 | 490 | 41 |
| 1974-08-13 | @ CAL | 116 | W 3-0 | 64-52 | 1 | 8,873 | Luis Tiant | Ed Figueroa | Luis Tiant | Ed Figueroa | | 534 | 490 | 44 |
| 1974-08-14 | @ CAL | 117 | L 0-5 | 64-53 | 1 | 8,043 | Bill Lee | Frank Tanana | Frank Tanana | Bill Lee | | 534 | 495 | 39 |
| 1974-08-16 | vs MIN | 118 | W 3-2 | 65-53 | 1 | 33,218 | Juan Marichal | Bill Hands | Diego Segui | Bill Campbell | | 537 | 497 | 40 |
| 1974-08-17 | vs MIN | 119 | L 4-7 | 65-54 | 1 | 27,979 | Roger Moret | Dave Goltz | Dave Goltz | Reggie Cleveland | Tom Burgmeier | 541 | 504 | 37 |
| 1974-08-18 | vs MIN | 120 | W 9-6 | 66-54 | 1 | 24,384 | Luis Tiant | Ray Corbin | Luis Tiant | Ray Corbin | | 550 | 510 | 40 |
| 1974-08-19 | vs CHA | 121 | W 6-1 | 67-54 | 1 | 23,923 | Bill Lee | Jim Kaat | Bill Lee | Jim Kaat | Diego Segui | 556 | 511 | 45 |
| 1974-08-20 | vs CHA | 122 | W 8-3 | 68-54 | 1 | 27,881 | Dick Drago | Stan Bahnsen | Dick Drago | Stan Bahnsen | | 564 | 514 | 50 |
| 1974-08-21 | vs CHA | 123 | W 4-0 | 69-54 | 1 | 32,395 | Roger Moret | Wilbur Wood | Roger Moret | Wilbur Wood | | 568 | 514 | 54 |
| 1974-08-23 | vs OAK | 124 | W 3-0 | 70-54 | 1 | 35,866 | Luis Tiant | Vida Blue | Luis Tiant | Vida Blue | | 571 | 514 | 57 |
| 1974-08-24 | vs OAK | 125 | L 1-4 | 70-55 | 1 | 34,693 | Bill Lee | Catfish Hunter | Catfish Hunter | Diego Segui | | 572 | 518 | 54 |
| 1974-08-25 | vs OAK | 126 | L 0-7 | 70-56 | 1 | 34,293 | Roger Moret | Ken Holtzman | Ken Holtzman | Roger Moret | | 572 | 525 | 47 |
| 1974-08-27 | @ CHA | 127 | W 6-1 | 71-56 | 1 | 12,009 | Reggie Cleveland | Jim Kaat | Reggie Cleveland | Jim Kaat | | 578 | 526 | 52 |
| 1974-08-28 | @ CHA | 128 | L 0-3 | 71-57 | 1 | 11,642 | Luis Tiant | Bart Johnson | Bart Johnson | Luis Tiant | | 578 | 529 | 49 |
| 1974-08-29 | @ CHA | 129 | W 3-2 | 72-57 | 1 | 11,656 | Bill Lee | Wilbur Wood | Bill Lee | Wilbur Wood | Diego Segui | 581 | 531 | 50 |
| 1974-08-30 | @ MIN | 130 | L 2-3 | 72-58 | 1 | 7,337 | Roger Moret | Bert Blyleven | Bert Blyleven | Roger Moret | | 583 | 534 | 49 |
| 1974-08-31 | @ MIN | 131 | L 2-6 | 72-59 | 1 | 11,557 | Dick Drago | Dave Goltz | Dave Goltz | Dick Drago | | 585 | 540 | 45 |
| 1974-09-01 | @ MIN | 132 | L 6-9 | 72-60 | 1 | 11,769 | Reggie Cleveland | Bill Hands | Bill Campbell | Diego Segui | | 591 | 549 | 42 |
| 1974-09-02 | @ BAL | 133 | L 0-1 | 72-62 | 1 | 0 | Luis Tiant | Ross Grimsley | Ross Grimsley | Luis Tiant | | 591 | 550 | 41 |
| 1974-09-02 | @ BAL | 134 | L 0-1 | 72-62 | 1 | 29,053 | Bill Lee | Mike Cuellar | Mike Cuellar | Bill Lee | | 591 | 551 | 40 |
| 1974-09-04 | @ BAL | 135 | L 0-6 | 72-63 | 1 | 16,856 | Roger Moret | Jim Palmer | Jim Palmer | Roger Moret | | 591 | 557 | 34 |
| 1974-09-05 | vs MIL | 136 | L 3-4 | 72-64 | 2 | 14,592 | Dick Drago | Bill Champion | Bill Champion | Diego Segui | Tom Murphy | 594 | 561 | 33 |
| 1974-09-06 | vs MIL | 137 | L 0-2 | 72-65 | 3 | 19,257 | Luis Tiant | Jim Slaton | Jim Slaton | Luis Tiant | Tom Murphy | 594 | 563 | 31 |
| 1974-09-07 | vs MIL | 138 | W 4-3 | 73-65 | 3 | 16,553 | Bill Lee | Jim Colborn | Reggie Cleveland | Tom Murphy | | 598 | 566 | 32 |
| 1974-09-08 | vs MIL | 139 | W 8-6 | 74-65 | 1 | 25,531 | Juan Marichal | Eduardo Rodriguez | Dick Pole | Clyde Wright | Diego Segui | 606 | 572 | 34 |
| 1974-09-09 | vs NYA | 140 | L 3-6 | 74-66 | 3 | 34,981 | Roger Moret | Doc Medich | Doc Medich | Roger Moret | | 609 | 578 | 31 |
| 1974-09-10 | vs NYA | 141 | L 1-2 | 74-67 | 3 | 33,174 | Luis Tiant | Pat Dobson | Pat Dobson | Diego Segui | Sparky Lyle | 610 | 580 | 30 |
| 1974-09-11 | @ CLE | 142 | L 1-3 | 74-68 | 3 | 11,414 | Dick Drago | Gaylord Perry | Gaylord Perry | Dick Drago | | 611 | 583 | 28 |
| 1974-09-12 | @ CLE | 143 | W 3-2 | 75-68 | 2 | 9,710 | Bill Lee | Jim Perry | Bill Lee | Jim Perry | | 614 | 585 | 29 |
| 1974-09-13 | @ MIL | 144 | W 8-5 | 76-68 | 2 | 6,186 | Dick Pole | Eduardo Rodriguez | Roger Moret | Bill Travers | | 622 | 590 | 32 |
| 1974-09-14 | @ MIL | 145 | L 1-3 | 76-69 | 3 | 8,807 | Reggie Cleveland | Bill Champion | Bill Champion | Reggie Cleveland | | 623 | 593 | 30 |
| 1974-09-15 | @ MIL | 146 | L 5-9 | 76-70 | 3 | 7,313 | Luis Tiant | Jim Slaton | Clyde Wright | Luis Tiant | | 628 | 602 | 26 |
| 1974-09-17 | vs DET | 147 | L 3-5 | 76-71 | 3 | 12,213 | Bill Lee | Joe Coleman | Joe Coleman | Bill Lee | John Hiller | 631 | 607 | 24 |
| 1974-09-18 | vs DET | 148 | W 8-5 | 77-71 | 3 | 12,213 | Juan Marichal | Lerrin LaGrow | Reggie Cleveland | Lerrin LaGrow | | 639 | 612 | 27 |
| 1974-09-19 | vs DET | 149 | L 1-3 | 77-72 | 3 | 12,290 | Luis Tiant | Vern Ruhle | Vern Ruhle | Luis Tiant | | 640 | 615 | 25 |
| 1974-09-20 | vs BAL | 150 | L 1-2 | 77-73 | 3 | 27,283 | Dick Drago | Ross Grimsley | Ross Grimsley | Dick Drago | Grant Jackson | 641 | 617 | 24 |
| 1974-09-21 | vs BAL | 151 | W 6-5 | 78-73 | 3 | 21,555 | Bill Lee | Jim Palmer | Bill Lee | Dave Johnson | | 647 | 622 | 25 |
| 1974-09-22 | vs BAL | 152 | L 2-7 | 78-74 | 3 | 26,495 | Reggie Cleveland | Mike Cuellar | Mike Cuellar | Reggie Cleveland | | 649 | 629 | 20 |
| 1974-09-24 | @ NYA | 153 | W 4-0 | 80-74 | 3 | 0 | Luis Tiant | Rudy May | Luis Tiant | Rudy May | | 653 | 629 | 24 |
| 1974-09-24 | @ NYA | 154 | W 4-2 | 80-74 | 3 | 46,448 | Roger Moret | Larry Gura | Roger Moret | Larry Gura | | 657 | 631 | 26 |
| 1974-09-25 | @ NYA | 155 | L 0-1 | 80-75 | 3 | 23,104 | Bill Lee | Doc Medich | Doc Medich | Bill Lee | | 657 | 632 | 25 |
| 1974-09-26 | @ DET | 156 | W 5-3 | 81-75 | 3 | 7,636 | Dick Drago | Joe Coleman | Dick Drago | John Hiller | | 662 | 635 | 27 |
| 1974-09-27 | @ DET | 157 | W 9-3 | 82-75 | 3 | 8,177 | Reggie Cleveland | Woodie Fryman | Reggie Cleveland | Woodie Fryman | | 671 | 638 | 33 |
| 1974-09-28 | @ DET | 158 | W 7-2 | 83-75 | 3 | 10,035 | Luis Tiant | Lerrin LaGrow | Luis Tiant | Lerrin LaGrow | Dick Pole | 678 | 640 | 38 |
| 1974-09-29 | @ DET | 159 | L 4-7 | 83-76 | 3 | 21,178 | Roger Moret | Vern Ruhle | Vern Ruhle | Roger Moret | | 682 | 647 | 35 |
| 1974-09-30 | vs CLE | 160 | L 1-2 | 83-77 | 3 | 10,673 | Bill Lee | Jim Perry | Jim Perry | Bill Lee | Milt Wilcox | 683 | 649 | 34 |
| 1974-10-01 | vs CLE | 161 | W 7-4 | 84-77 | 3 | 9,784 | Steve Barr | Steve Kline | Steve Barr | Steve Kline | | 690 | 653 | 37 |
| 1974-10-02 | vs CLE | 162 | L 6-8 | 84-78 | 3 | 5,047 | Dick Pole | Gaylord Perry | Gaylord Perry | Dick Pole | | 696 | 661 | 35 |