| 1974-04-05 | @ CHA | 1 | W 8-2 | 1-0 | 3 | 30,041 | Nolan Ryan | Wilbur Wood | Nolan Ryan | Wilbur Wood | | 8 | 2 | 6 |
| 1974-04-06 | @ CHA | 2 | W 3-2 | 2-0 | 1 | 10,841 | Frank Tanana | Stan Bahnsen | Dick Selma | Stan Bahnsen | | 11 | 4 | 7 |
| 1974-04-07 | @ CHA | 3 | L 4-4 | 2-1 | 2 | 8,383 | Bill Singer | Jim Kaat | | | | 15 | 8 | 7 |
| 1974-04-09 | vs TEX | 4 | L 2-10 | 2-2 | 4 | 25,241 | Nolan Ryan | Jim Bibby | Jim Bibby | Nolan Ryan | | 17 | 18 | -1 |
| 1974-04-10 | vs TEX | 5 | W 4-3 | 3-2 | 3 | 6,463 | Frank Tanana | Fergie Jenkins | Frank Tanana | Fergie Jenkins | | 21 | 21 | 0 |
| 1974-04-11 | vs TEX | 6 | W 11-8 | 4-2 | 2 | 8,027 | Bill Singer | David Clyde | Bill Singer | Pete Broberg | | 32 | 29 | 3 |
| 1974-04-12 | vs CHA | 7 | W 15-1 | 5-2 | 2 | 12,439 | Nolan Ryan | Terry Forster | Nolan Ryan | Terry Forster | | 47 | 30 | 17 |
| 1974-04-13 | vs CHA | 8 | L 4-5 | 5-3 | 2 | 23,712 | Rudy May | Wilbur Wood | Wilbur Wood | Rudy May | | 51 | 35 | 16 |
| 1974-04-14 | vs CHA | 9 | W 6-3 | 6-3 | 2 | 9,365 | Frank Tanana | Stan Bahnsen | Frank Tanana | Stan Bahnsen | Dick Selma | 57 | 38 | 19 |
| 1974-04-15 | vs MIN | 10 | W 8-1 | 7-3 | 1 | 12,968 | Bill Singer | Bill Hands | Bill Singer | Bill Hands | | 65 | 39 | 26 |
| 1974-04-16 | vs MIN | 11 | L 0-6 | 7-4 | 2 | 9,529 | Nolan Ryan | Joe Decker | Joe Decker | Nolan Ryan | Bill Campbell | 65 | 45 | 20 |
| 1974-04-17 | vs MIN | 12 | W 5-3 | 8-4 | 1 | 7,259 | Bill Stoneman | Dick Woodson | Dave Sells | Dick Woodson | | 70 | 48 | 22 |
| 1974-04-18 | vs MIN | 13 | L 2-3 | 8-5 | 2 | 7,383 | Frank Tanana | Ray Corbin | Ray Corbin | Frank Tanana | Bill Campbell | 72 | 51 | 21 |
| 1974-04-19 | @ OAK | 14 | L 1-5 | 8-6 | 4 | 5,347 | Bill Singer | Catfish Hunter | Catfish Hunter | Bill Singer | | 73 | 56 | 17 |
| 1974-04-20 | @ OAK | 15 | L 6-7 | 8-7 | 4 | 5,985 | Nolan Ryan | Ken Holtzman | Rollie Fingers | Dick Selma | | 79 | 63 | 16 |
| 1974-04-21 | @ OAK | 16 | W 9-5 | 9-7 | 4 | 8,449 | Bill Stoneman | Vida Blue | Skip Lockwood | Rollie Fingers | | 88 | 68 | 20 |
| 1974-04-23 | @ BAL | 17 | L 3-4 | 9-8 | 4 | 3,743 | Frank Tanana | Ross Grimsley | Bob Reynolds | Dave Sells | | 91 | 72 | 19 |
| 1974-04-24 | @ BAL | 18 | L 3-4 | 9-9 | 4 | 3,549 | Bill Singer | Dave McNally | Dave McNally | Bill Singer | Bob Reynolds | 94 | 76 | 18 |
| 1974-04-26 | @ CLE | 19 | L 3-4 | 9-10 | 4 | 6,423 | Nolan Ryan | Bob Johnson | Tom Timmermann | Nolan Ryan | Milt Wilcox | 97 | 80 | 17 |
| 1974-04-27 | @ CLE | 20 | L 0-6 | 9-11 | 5 | 12,381 | Bill Stoneman | Jim Perry | Jim Perry | Bill Stoneman | | 97 | 86 | 11 |
| 1974-04-28 | @ CLE | 21 | L 2-10 | 9-12 | 5 | 11,581 | Frank Tanana | Gaylord Perry | Gaylord Perry | Frank Tanana | | 99 | 96 | 3 |
| 1974-04-29 | @ BOS | 22 | W 7-2 | 10-12 | 4 | 9,674 | Bill Singer | Luis Tiant | Bill Singer | Luis Tiant | | 106 | 98 | 8 |
| 1974-04-30 | @ BOS | 23 | W 16-6 | 11-12 | 3 | 7,395 | Nolan Ryan | Reggie Cleveland | Nolan Ryan | Reggie Cleveland | | 122 | 104 | 18 |
| 1974-05-01 | @ BOS | 24 | W 4-2 | 12-12 | 2 | 6,534 | Bill Stoneman | Bill Lee | Bill Stoneman | Bill Lee | Rudy May | 126 | 106 | 20 |
| 1974-05-03 | vs BAL | 25 | W 2-0 | 13-12 | 2 | 11,139 | Frank Tanana | Ross Grimsley | Frank Tanana | Ross Grimsley | Rudy May | 128 | 106 | 22 |
| 1974-05-04 | vs BAL | 26 | W 3-1 | 14-12 | 2 | 35,084 | Bill Singer | Jim Palmer | Bill Singer | Jim Palmer | | 131 | 107 | 24 |
| 1974-05-05 | vs BAL | 27 | W 8-7 | 15-12 | 2 | 12,124 | Nolan Ryan | Dave McNally | Dick Selma | Grant Jackson | | 139 | 114 | 25 |
| 1974-05-06 | vs CLE | 28 | L 3-5 | 15-13 | 2 | 14,234 | Bill Stoneman | Fritz Peterson | Fritz Peterson | Bill Stoneman | Milt Wilcox | 142 | 119 | 23 |
| 1974-05-07 | vs CLE | 29 | L 3-5 | 15-14 | 4 | 6,727 | Frank Tanana | Jim Perry | Fred Beene | Frank Tanana | Tom Hilgendorf | 145 | 124 | 21 |
| 1974-05-08 | vs CLE | 30 | L 2-3 | 15-15 | 4 | 6,649 | Bill Singer | Gaylord Perry | Tom Hilgendorf | Dave Sells | Tom Buskey | 147 | 127 | 20 |
| 1974-05-10 | vs KCA | 31 | W 2-1 | 16-15 | 2 | 12,534 | Nolan Ryan | Paul Splittorff | Nolan Ryan | Paul Splittorff | | 149 | 128 | 21 |
| 1974-05-11 | vs KCA | 32 | L 2-10 | 16-16 | 4 | 15,011 | Bill Stoneman | Steve Busby | Steve Busby | Bill Stoneman | | 151 | 138 | 13 |
| 1974-05-12 | vs KCA | 33 | L 2-3 | 16-18 | 5 | 0 | Frank Tanana | Al Fitzmorris | Doug Bird | Frank Tanana | | 153 | 141 | 12 |
| 1974-05-12 | vs KCA | 34 | L 2-5 | 16-18 | 5 | 13,162 | Dick Lange | Bruce Dal Canton | Joe Hoerner | Dick Selma | | 155 | 146 | 9 |
| 1974-05-13 | @ TEX | 35 | W 8-4 | 17-18 | 3 | 6,632 | Bill Singer | Jim Bibby | Bill Singer | Jim Bibby | | 163 | 150 | 13 |
| 1974-05-15 | @ TEX | 36 | L 1-6 | 17-19 | 5 | 13,209 | Nolan Ryan | David Clyde | David Clyde | Nolan Ryan | | 164 | 156 | 8 |
| 1974-05-17 | @ MIN | 37 | L 1-2 | 17-20 | 6 | 4,695 | Frank Tanana | Joe Decker | Joe Decker | Frank Tanana | Bill Campbell | 165 | 158 | 7 |
| 1974-05-18 | @ MIN | 38 | L 4-10 | 17-21 | 6 | 4,380 | Bill Singer | Dave Goltz | Ray Corbin | Bill Singer | | 169 | 168 | 1 |
| 1974-05-19 | @ MIN | 39 | W 4-2 | 18-22 | 6 | 0 | Nolan Ryan | Bert Blyleven | Nolan Ryan | Bert Blyleven | | 173 | 170 | 3 |
| 1974-05-19 | @ MIN | 40 | L 2-4 | 18-22 | 6 | 6,714 | Bill Stoneman | Vic Albury | Vic Albury | Bill Stoneman | | 175 | 174 | 1 |
| 1974-05-21 | @ KCA | 41 | L 2-4 | 18-23 | 6 | 9,814 | Frank Tanana | Steve Busby | Steve Busby | Frank Tanana | Joe Hoerner | 177 | 178 | -1 |
| 1974-05-22 | @ KCA | 42 | W 6-1 | 19-23 | 6 | 10,221 | Bill Singer | Al Fitzmorris | Bill Singer | Al Fitzmorris | | 183 | 179 | 4 |
| 1974-05-23 | @ KCA | 43 | W 3-1 | 20-23 | 5 | 15,600 | Nolan Ryan | Bruce Dal Canton | Nolan Ryan | Bruce Dal Canton | | 186 | 180 | 6 |
| 1974-05-24 | vs OAK | 44 | W 4-3 | 21-23 | 4 | 24,855 | Dick Lange | Catfish Hunter | Dick Lange | Catfish Hunter | Dave Sells | 190 | 183 | 7 |
| 1974-05-25 | vs OAK | 45 | W 8-2 | 22-23 | 4 | 17,798 | Frank Tanana | Ken Holtzman | Frank Tanana | Ken Holtzman | | 198 | 185 | 13 |
| 1974-05-26 | vs OAK | 46 | L 5-6 | 22-24 | 4 | 13,329 | Bill Singer | Dave Hamilton | Rollie Fingers | Dave Sells | | 203 | 191 | 12 |
| 1974-05-27 | vs MIL | 47 | L 0-2 | 22-25 | 5 | 9,211 | Nolan Ryan | Kevin Kobel | Kevin Kobel | Nolan Ryan | | 203 | 193 | 10 |
| 1974-05-28 | vs MIL | 48 | L 2-6 | 22-26 | 5 | 5,330 | Dick Lange | Jim Slaton | Jim Slaton | Dick Lange | | 205 | 199 | 6 |
| 1974-05-29 | vs MIL | 49 | L 5-7 | 22-27 | 6 | 6,787 | Frank Tanana | Clyde Wright | Eduardo Rodriguez | Skip Lockwood | | 210 | 206 | 4 |
| 1974-05-31 | vs DET | 50 | W 5-3 | 23-27 | 6 | 10,760 | Bill Singer | Mickey Lolich | Bill Singer | Mickey Lolich | | 215 | 209 | 6 |
| 1974-06-01 | vs DET | 51 | W 4-1 | 24-27 | 5 | 16,481 | Nolan Ryan | Joe Coleman | Nolan Ryan | Joe Coleman | | 219 | 210 | 9 |
| 1974-06-02 | vs DET | 52 | L 0-2 | 24-28 | 5 | 16,550 | Dick Lange | Woodie Fryman | Woodie Fryman | Dick Lange | John Hiller | 219 | 212 | 7 |
| 1974-06-04 | @ MIL | 53 | L 3-4 | 24-29 | 6 | 9,408 | Bill Singer | Kevin Kobel | Eduardo Rodriguez | Bill Singer | Tom Murphy | 222 | 216 | 6 |
| 1974-06-05 | @ MIL | 54 | W 6-5 | 25-29 | 5 | 6,367 | Nolan Ryan | Jim Slaton | Skip Lockwood | Eduardo Rodriguez | | 228 | 221 | 7 |
| 1974-06-06 | @ MIL | 55 | L 7-9 | 25-30 | 5 | 7,722 | Rudy May | Clyde Wright | Tom Murphy | Skip Lockwood | | 235 | 230 | 5 |
| 1974-06-07 | @ DET | 56 | L 4-5 | 25-31 | 6 | 15,007 | Dick Lange | Woodie Fryman | John Hiller | John Cumberland | | 239 | 235 | 4 |
| 1974-06-08 | @ DET | 57 | L 2-5 | 25-32 | 6 | 12,053 | Frank Tanana | Mickey Lolich | Mickey Lolich | Frank Tanana | | 241 | 240 | 1 |
| 1974-06-09 | @ DET | 58 | L 3-5 | 25-33 | 6 | 42,491 | Nolan Ryan | Lerrin LaGrow | Lerrin LaGrow | Nolan Ryan | John Hiller | 244 | 245 | -1 |
| 1974-06-10 | @ NYA | 59 | L 5-7 | 25-34 | 6 | 11,510 | Rudy May | Doc Medich | Sparky Lyle | Skip Lockwood | | 249 | 252 | -3 |
| 1974-06-11 | @ NYA | 60 | W 5-4 | 26-34 | 6 | 10,884 | Dick Lange | Mel Stottlemyre | Dick Lange | Dave Pagan | Barry Raziano | 254 | 256 | -2 |
| 1974-06-12 | @ NYA | 61 | L 4-6 | 26-35 | 6 | 7,473 | Frank Tanana | Pat Dobson | Pat Dobson | Frank Tanana | Cecil Upshaw | 258 | 262 | -4 |
| 1974-06-14 | vs BOS | 62 | W 4-3 | 27-35 | 6 | 11,083 | Nolan Ryan | Luis Tiant | Barry Raziano | Luis Tiant | | 262 | 265 | -3 |
| 1974-06-15 | vs BOS | 63 | L 3-5 | 27-36 | 6 | 26,401 | Bill Stoneman | Bill Lee | Bill Lee | Bill Stoneman | Diego Segui | 265 | 270 | -5 |
| 1974-06-16 | vs BOS | 64 | L 4-7 | 27-37 | 6 | 11,828 | Dick Lange | Reggie Cleveland | Reggie Cleveland | Barry Raziano | | 269 | 277 | -8 |
| 1974-06-17 | vs NYA | 65 | L 1-5 | 27-38 | 6 | 18,150 | Frank Tanana | Dave Pagan | Mike Wallace | Frank Tanana | | 270 | 282 | -12 |
| 1974-06-18 | vs NYA | 66 | W 3-0 | 28-38 | 6 | 10,830 | Nolan Ryan | Dick Tidrow | Nolan Ryan | Dick Tidrow | Skip Lockwood | 273 | 282 | -9 |
| 1974-06-19 | vs NYA | 67 | L 1-2 | 28-39 | 6 | 9,628 | Andy Hassler | Doc Medich | Doc Medich | Andy Hassler | | 274 | 284 | -10 |
| 1974-06-20 | @ TEX | 68 | L 4-7 | 28-40 | 6 | 10,031 | Dick Lange | David Clyde | Steve Foucault | Barry Raziano | | 278 | 291 | -13 |
| 1974-06-21 | @ TEX | 69 | L 3-12 | 28-42 | 6 | 0 | Bill Stoneman | Fergie Jenkins | Fergie Jenkins | Bill Stoneman | | 281 | 303 | -22 |
| 1974-06-21 | @ TEX | 70 | L 2-6 | 28-42 | 6 | 26,169 | Frank Tanana | Steve Hargan | Steve Hargan | Frank Tanana | | 283 | 309 | -26 |
| 1974-06-22 | @ TEX | 71 | W 7-4 | 29-42 | 6 | 30,130 | Nolan Ryan | Jim Bibby | Nolan Ryan | Jim Bibby | | 290 | 313 | -23 |
| 1974-06-23 | @ TEX | 72 | W 10-2 | 30-42 | 6 | 12,599 | Andy Hassler | Jackie Brown | Andy Hassler | Jackie Brown | | 300 | 315 | -15 |
| 1974-06-24 | @ OAK | 73 | L 3-11 | 30-43 | 6 | 4,978 | Dick Lange | Vida Blue | Vida Blue | Dick Lange | | 303 | 326 | -23 |
| 1974-06-25 | @ OAK | 74 | L 1-6 | 30-44 | 6 | 4,344 | Frank Tanana | Catfish Hunter | Catfish Hunter | Frank Tanana | | 304 | 332 | -28 |
| 1974-06-26 | @ OAK | 75 | L 0-5 | 30-45 | 6 | 5,851 | Bill Stoneman | Dave Hamilton | Dave Hamilton | Bill Stoneman | | 304 | 337 | -33 |
| 1974-06-27 | vs TEX | 76 | W 5-0 | 31-45 | 6 | 8,066 | Nolan Ryan | Jackie Brown | Nolan Ryan | Jackie Brown | | 309 | 337 | -28 |
| 1974-06-28 | vs TEX | 77 | L 3-5 | 31-46 | 6 | 7,285 | Andy Hassler | Steve Hargan | Steve Hargan | Andy Hassler | Steve Foucault | 312 | 342 | -30 |
| 1974-06-29 | vs TEX | 78 | W 8-3 | 32-46 | 6 | 15,001 | Dick Lange | Fergie Jenkins | Dick Lange | Fergie Jenkins | | 320 | 345 | -25 |
| 1974-06-30 | vs TEX | 79 | L 2-9 | 32-47 | 6 | 6,574 | Bill Stoneman | Jim Bibby | Jim Bibby | Bill Stoneman | | 322 | 354 | -32 |
| 1974-07-01 | vs OAK | 80 | L 3-5 | 32-48 | 6 | 16,405 | Nolan Ryan | Dave Hamilton | Rollie Fingers | Nolan Ryan | | 325 | 359 | -34 |
| 1974-07-02 | vs OAK | 81 | L 5-7 | 32-49 | 6 | 9,533 | Frank Tanana | Ken Holtzman | Ken Holtzman | Frank Tanana | Paul Lindblad | 330 | 366 | -36 |
| 1974-07-03 | vs OAK | 82 | L 2-3 | 32-50 | 6 | 9,979 | Andy Hassler | Glenn Abbott | Glenn Abbott | Andy Hassler | | 332 | 369 | -37 |
| 1974-07-04 | vs OAK | 83 | L 4-9 | 32-51 | 6 | 41,760 | Dick Lange | Vida Blue | Vida Blue | Dick Lange | | 336 | 378 | -42 |
| 1974-07-05 | vs CLE | 84 | L 2-7 | 32-52 | 6 | 9,826 | Nolan Ryan | Fritz Peterson | Fritz Peterson | Nolan Ryan | | 338 | 385 | -47 |
| 1974-07-06 | vs CLE | 85 | L 0-1 | 32-53 | 6 | 9,317 | Ed Figueroa | Dick Bosman | Dick Bosman | Ed Figueroa | Tom Buskey | 338 | 386 | -48 |
| 1974-07-07 | vs CLE | 86 | L 2-6 | 32-54 | 6 | 8,394 | Frank Tanana | Jim Perry | Jim Perry | Frank Tanana | Milt Wilcox | 340 | 392 | -52 |
| 1974-07-08 | vs BAL | 87 | L 5-6 | 32-55 | 6 | 15,261 | Andy Hassler | Doyle Alexander | Wayne Garland | Andy Hassler | Dave Johnson | 345 | 398 | -53 |
| 1974-07-09 | vs BAL | 88 | L 1-3 | 32-56 | 6 | 8,213 | Dick Lange | Mike Cuellar | Mike Cuellar | Dick Lange | Bob Reynolds | 346 | 401 | -55 |
| 1974-07-10 | vs BAL | 89 | L 1-9 | 32-57 | 6 | 6,731 | Nolan Ryan | Ross Grimsley | Ross Grimsley | Nolan Ryan | | 347 | 410 | -63 |
| 1974-07-12 | @ BOS | 90 | W 7-0 | 33-57 | 6 | 24,821 | Ed Figueroa | Roger Moret | Ed Figueroa | Roger Moret | | 354 | 410 | -56 |
| 1974-07-13 | @ BOS | 91 | W 12-1 | 34-57 | 6 | 23,862 | Andy Hassler | Dick Drago | Andy Hassler | Dick Drago | | 366 | 411 | -45 |
| 1974-07-14 | @ BOS | 92 | L 0-3 | 34-58 | 6 | 17,199 | Dick Lange | Luis Tiant | Luis Tiant | Dick Lange | | 366 | 414 | -48 |
| 1974-07-15 | @ CLE | 93 | W 4-2 | 35-58 | 6 | 17,597 | Nolan Ryan | Steve Arlin | Nolan Ryan | Steve Arlin | Dave Sells | 370 | 416 | -46 |
| 1974-07-16 | @ CLE | 94 | W 11-2 | 36-58 | 6 | 8,303 | Ed Figueroa | Fritz Peterson | Frank Tanana | Fritz Peterson | | 381 | 418 | -37 |
| 1974-07-17 | @ CLE | 95 | W 7-5 | 37-58 | 6 | 5,204 | Andy Hassler | Jim Perry | Dave Sells | Tom Buskey | | 388 | 423 | -35 |
| 1974-07-19 | @ BAL | 96 | L 4-5 | 37-59 | 6 | 14,027 | Dick Lange | Ross Grimsley | Don Hood | Skip Lockwood | | 392 | 428 | -36 |
| 1974-07-20 | @ BAL | 97 | W 2-0 | 38-60 | 6 | 0 | Nolan Ryan | Wayne Garland | Nolan Ryan | Wayne Garland | | 394 | 428 | -34 |
| 1974-07-20 | @ BAL | 98 | L 2-5 | 38-60 | 6 | 23,379 | Ed Figueroa | Mike Cuellar | Mike Cuellar | Ed Figueroa | | 396 | 433 | -37 |
| 1974-07-21 | @ BAL | 99 | W 6-4 | 39-60 | 6 | 13,443 | Andy Hassler | Dave McNally | Frank Tanana | Dave McNally | | 402 | 437 | -35 |
| 1974-07-25 | vs KCA | 100 | L 1-2 | 39-61 | 6 | 11,334 | Nolan Ryan | Paul Splittorff | Paul Splittorff | Nolan Ryan | Doug Bird | 403 | 439 | -36 |
| 1974-07-26 | vs KCA | 101 | L 2-3 | 39-62 | 6 | 9,131 | Dick Lange | Steve Busby | Steve Busby | Luis Quintana | | 405 | 442 | -37 |
| 1974-07-27 | vs KCA | 102 | L 3-6 | 39-63 | 6 | 12,008 | Ed Figueroa | Bruce Dal Canton | Bruce Dal Canton | Ed Figueroa | | 408 | 448 | -40 |
| 1974-07-28 | vs MIN | 103 | L 3-5 | 40-64 | 6 | 0 | Andy Hassler | Dave Goltz | Dave Goltz | Andy Hassler | Bill Campbell | 411 | 453 | -42 |
| 1974-07-28 | vs MIN | 104 | W 12-9 | 40-64 | 6 | 0 | Frank Tanana | Vic Albury | Nolan Ryan | Tom Burgmeier | | 423 | 462 | -39 |
| 1974-07-30 | vs CHA | 105 | L 2-3 | 40-65 | 6 | 10,029 | Nolan Ryan | Jim Kaat | Jim Kaat | Nolan Ryan | Terry Forster | 425 | 465 | -40 |
| 1974-07-31 | vs CHA | 106 | W 14-4 | 41-65 | 6 | 8,236 | Dick Lange | Bart Johnson | Luis Quintana | Skip Pitlock | | 439 | 469 | -30 |
| 1974-08-01 | @ MIN | 107 | L 5-6 | 41-66 | 6 | 6,233 | Andy Hassler | Ray Corbin | Tom Burgmeier | Horacio Pina | Bill Campbell | 444 | 475 | -31 |
| 1974-08-02 | @ MIN | 108 | W 3-2 | 42-66 | 6 | 9,453 | Ed Figueroa | Dave Goltz | Ed Figueroa | Dave Goltz | | 447 | 477 | -30 |
| 1974-08-03 | @ KCA | 109 | W 4-3 | 43-66 | 6 | 15,277 | Nolan Ryan | Paul Splittorff | Nolan Ryan | Paul Splittorff | | 451 | 480 | -29 |
| 1974-08-04 | @ KCA | 110 | L 4-10 | 43-68 | 6 | 0 | Dick Lange | Steve Busby | Steve Busby | Dick Lange | Steve Mingori | 455 | 490 | -35 |
| 1974-08-04 | @ KCA | 111 | L 0-3 | 43-68 | 6 | 22,793 | Frank Tanana | Al Fitzmorris | Al Fitzmorris | Frank Tanana | Joe Hoerner | 455 | 493 | -38 |
| 1974-08-06 | @ CHA | 112 | L 2-12 | 43-69 | 6 | 11,896 | Andy Hassler | Wilbur Wood | Wilbur Wood | Andy Hassler | | 457 | 505 | -48 |
| 1974-08-07 | @ CHA | 113 | L 1-2 | 43-70 | 6 | 11,636 | Nolan Ryan | Jim Kaat | Jim Kaat | Nolan Ryan | | 458 | 507 | -49 |
| 1974-08-08 | @ CHA | 114 | W 6-4 | 44-70 | 6 | 14,901 | Ed Figueroa | Bart Johnson | Luis Quintana | Rich Gossage | Andy Hassler | 464 | 511 | -47 |
| 1974-08-09 | vs NYA | 115 | W 7-1 | 45-70 | 6 | 10,203 | Frank Tanana | Doc Medich | Frank Tanana | Doc Medich | | 471 | 512 | -41 |
| 1974-08-10 | vs NYA | 116 | L 1-2 | 45-71 | 6 | 28,534 | Andy Hassler | Rudy May | Rudy May | Andy Hassler | | 472 | 514 | -42 |
| 1974-08-11 | vs NYA | 117 | L 4-5 | 45-72 | 6 | 9,192 | Dick Lange | Dick Tidrow | Dick Tidrow | Dick Lange | Cecil Upshaw | 476 | 519 | -43 |
| 1974-08-12 | vs BOS | 118 | W 4-2 | 46-72 | 6 | 9,345 | Nolan Ryan | Roger Moret | Nolan Ryan | Roger Moret | | 480 | 521 | -41 |
| 1974-08-13 | vs BOS | 119 | L 0-3 | 46-73 | 6 | 8,873 | Ed Figueroa | Luis Tiant | Luis Tiant | Ed Figueroa | | 480 | 524 | -44 |
| 1974-08-14 | vs BOS | 120 | W 5-0 | 47-73 | 6 | 8,043 | Frank Tanana | Bill Lee | Frank Tanana | Bill Lee | | 485 | 524 | -39 |
| 1974-08-16 | vs MIL | 121 | W 7-3 | 48-73 | 6 | 15,397 | Nolan Ryan | Clyde Wright | Nolan Ryan | Clyde Wright | Ken Sanders | 492 | 527 | -35 |
| 1974-08-17 | vs MIL | 122 | L 2-4 | 48-74 | 6 | 7,181 | Andy Hassler | Jim Colborn | Jim Colborn | Andy Hassler | Tom Murphy | 494 | 531 | -37 |
| 1974-08-18 | vs MIL | 123 | L 2-5 | 48-75 | 6 | 7,008 | Ed Figueroa | Jim Slaton | Jim Slaton | Ed Figueroa | Tom Murphy | 496 | 536 | -40 |
| 1974-08-19 | vs DET | 124 | W 1-0 | 49-75 | 6 | 16,694 | Frank Tanana | Fred Holdsworth | Frank Tanana | Fred Holdsworth | | 497 | 536 | -39 |
| 1974-08-20 | vs DET | 125 | L 0-1 | 49-76 | 6 | 12,433 | Nolan Ryan | Mickey Lolich | Mickey Lolich | Nolan Ryan | | 497 | 537 | -40 |
| 1974-08-21 | vs DET | 126 | W 2-0 | 50-76 | 6 | 8,419 | Andy Hassler | Lerrin LaGrow | Andy Hassler | Lerrin LaGrow | | 499 | 537 | -38 |
| 1974-08-23 | @ NYA | 127 | L 4-10 | 50-77 | 6 | 13,893 | Skip Lockwood | Rudy May | Dick Tidrow | Skip Lockwood | | 503 | 547 | -44 |
| 1974-08-24 | @ NYA | 128 | L 1-3 | 50-78 | 6 | 10,535 | Frank Tanana | Pat Dobson | Pat Dobson | Frank Tanana | Cecil Upshaw | 504 | 550 | -46 |
| 1974-08-25 | @ NYA | 129 | L 1-2 | 50-79 | 6 | 17,745 | Nolan Ryan | Larry Gura | Larry Gura | Nolan Ryan | | 505 | 552 | -47 |
| 1974-08-26 | @ DET | 130 | L 2-6 | 50-80 | 6 | 12,323 | Andy Hassler | Lerrin LaGrow | Lerrin LaGrow | Andy Hassler | | 507 | 558 | -51 |
| 1974-08-27 | @ DET | 131 | W 7-6 | 51-80 | 6 | 8,479 | Skip Lockwood | Joe Coleman | Horacio Pina | John Hiller | | 514 | 564 | -50 |
| 1974-08-28 | @ DET | 132 | L 1-2 | 51-81 | 6 | 9,513 | Frank Tanana | Mickey Lolich | Mickey Lolich | Frank Tanana | | 515 | 566 | -51 |
| 1974-08-30 | @ MIL | 133 | W 9-2 | 52-81 | 6 | 7,727 | Nolan Ryan | Kevin Kobel | Nolan Ryan | Kevin Kobel | | 524 | 568 | -44 |
| 1974-08-31 | @ MIL | 134 | L 5-6 | 52-82 | 6 | 7,520 | Andy Hassler | Bill Champion | Tom Murphy | Horacio Pina | | 529 | 574 | -45 |
| 1974-09-01 | @ MIL | 135 | L 1-3 | 52-83 | 6 | 11,498 | Ed Figueroa | Jim Slaton | Jim Slaton | Ed Figueroa | | 530 | 577 | -47 |
| 1974-09-02 | @ OAK | 136 | L 4-6 | 52-84 | 6 | 25,640 | Frank Tanana | Glenn Abbott | Glenn Abbott | Frank Tanana | Rollie Fingers | 534 | 583 | -49 |
| 1974-09-03 | @ OAK | 137 | L 0-7 | 52-85 | 6 | 4,341 | Nolan Ryan | Ken Holtzman | Ken Holtzman | Nolan Ryan | | 534 | 590 | -56 |
| 1974-09-04 | @ OAK | 138 | W 5-2 | 53-85 | 6 | 3,218 | Andy Hassler | Vida Blue | Andy Hassler | Vida Blue | | 539 | 592 | -53 |
| 1974-09-05 | vs CHA | 139 | L 0-1 | 53-86 | 6 | 5,057 | Ed Figueroa | Bart Johnson | Bart Johnson | Ed Figueroa | Terry Forster | 539 | 593 | -54 |
| 1974-09-06 | vs CHA | 140 | W 4-2 | 54-86 | 6 | 5,612 | Frank Tanana | Wilbur Wood | Frank Tanana | Wilbur Wood | Orlando Pena | 543 | 595 | -52 |
| 1974-09-07 | vs CHA | 141 | W 3-1 | 55-86 | 6 | 13,510 | Nolan Ryan | Jack Kucek | Nolan Ryan | Jack Kucek | | 546 | 596 | -50 |
| 1974-09-08 | vs CHA | 142 | L 0-1 | 55-87 | 6 | 9,663 | Andy Hassler | Jim Kaat | Jim Kaat | Andy Hassler | Terry Forster | 546 | 597 | -51 |
| 1974-09-09 | vs TEX | 143 | W 4-1 | 56-88 | 6 | 0 | Chuck Dobson | Jackie Brown | Chuck Dobson | Jackie Brown | | 550 | 598 | -48 |
| 1974-09-09 | vs TEX | 144 | L 3-5 | 56-88 | 6 | 6,724 | Ed Figueroa | Bill Hands | Bill Hands | Ed Figueroa | Steve Foucault | 553 | 603 | -50 |
| 1974-09-10 | vs KCA | 145 | W 8-2 | 57-88 | 6 | 4,491 | Frank Tanana | Dennis Leonard | Frank Tanana | Dennis Leonard | | 561 | 605 | -44 |
| 1974-09-11 | vs KCA | 146 | W 3-2 | 58-88 | 6 | 5,170 | Nolan Ryan | Al Fitzmorris | Nolan Ryan | Al Fitzmorris | | 564 | 607 | -43 |
| 1974-09-13 | @ CHA | 147 | L 0-8 | 58-90 | 6 | 0 | Chuck Dobson | Jim Kaat | Jim Kaat | Chuck Dobson | | 564 | 615 | -51 |
| 1974-09-13 | @ CHA | 148 | L 1-3 | 58-90 | 6 | 11,874 | Andy Hassler | Bart Johnson | Bart Johnson | Andy Hassler | Terry Forster | 565 | 618 | -53 |
| 1974-09-14 | @ CHA | 149 | W 5-0 | 59-90 | 6 | 9,511 | Frank Tanana | Wilbur Wood | Frank Tanana | Wilbur Wood | | 570 | 618 | -48 |
| 1974-09-15 | @ CHA | 150 | W 6-2 | 60-90 | 6 | 6,523 | Nolan Ryan | Jack Kucek | Nolan Ryan | Jack Kucek | | 576 | 620 | -44 |
| 1974-09-18 | @ TEX | 151 | W 4-1 | 61-91 | 6 | 0 | Andy Hassler | Fergie Jenkins | Andy Hassler | Fergie Jenkins | Orlando Pena | 580 | 621 | -41 |
| 1974-09-18 | @ TEX | 152 | L 0-2 | 61-91 | 6 | 6,908 | Frank Tanana | Steve Hargan | Steve Hargan | Frank Tanana | | 580 | 623 | -43 |
| 1974-09-20 | @ MIN | 153 | L 2-3 | 61-92 | 6 | 4,312 | Nolan Ryan | Joe Decker | Joe Decker | Nolan Ryan | | 582 | 626 | -44 |
| 1974-09-21 | @ MIN | 154 | L 1-8 | 61-93 | 6 | 4,631 | Chuck Dobson | Bert Blyleven | Bert Blyleven | Chuck Dobson | | 583 | 634 | -51 |
| 1974-09-22 | @ MIN | 155 | L 2-6 | 61-94 | 6 | 4,029 | Frank Tanana | Vic Albury | Vic Albury | Frank Tanana | | 585 | 640 | -55 |
| 1974-09-24 | @ KCA | 156 | W 9-3 | 62-94 | 6 | 7,003 | Nolan Ryan | Paul Splittorff | Nolan Ryan | Paul Splittorff | | 594 | 643 | -49 |
| 1974-09-25 | @ KCA | 157 | W 7-0 | 63-94 | 6 | 6,766 | Andy Hassler | Nelson Briles | Andy Hassler | Nelson Briles | Orlando Pena | 601 | 643 | -42 |
| 1974-09-26 | @ KCA | 158 | L 1-10 | 63-95 | 6 | 6,795 | Chuck Dobson | Steve Busby | Steve Busby | Chuck Dobson | | 602 | 653 | -51 |
| 1974-09-27 | vs MIN | 159 | W 3-2 | 64-95 | 6 | 4,946 | Frank Tanana | Vic Albury | Frank Tanana | Vic Albury | | 605 | 655 | -50 |
| 1974-09-28 | vs MIN | 160 | W 4-0 | 65-95 | 6 | 10,872 | Nolan Ryan | Joe Decker | Nolan Ryan | Joe Decker | | 609 | 655 | -46 |
| 1974-09-29 | vs MIN | 161 | W 4-0 | 66-95 | 6 | 4,959 | Andy Hassler | Bert Blyleven | Andy Hassler | Bert Blyleven | | 613 | 655 | -42 |
| 1974-10-01 | vs OAK | 162 | W 2-0 | 67-95 | 6 | 5,058 | Frank Tanana | Catfish Hunter | Frank Tanana | Ken Holtzman | | 615 | 655 | -40 |
| 1974-10-02 | vs OAK | 163 | W 3-2 | 68-95 | 6 | 6,861 | Chuck Dobson | Vida Blue | Chuck Dobson | Paul Lindblad | | 618 | 657 | -39 |