| 1974-04-05 | vs PIT | 1 | W 6-5 | 1-0 | 1 | 24,210 | Bob Gibson | Jerry Reuss | Al Hrabosky | Dave Giusti | | 6 | 5 | 1 |
| 1974-04-06 | vs PIT | 2 | W 8-0 | 2-0 | 2 | 17,875 | Sonny Siebert | Bob Moose | Sonny Siebert | Bob Moose | | 14 | 5 | 9 |
| 1974-04-10 | @ NYN | 3 | L 2-3 | 2-1 | 4 | 17,154 | John Curtis | Jerry Koosman | Jerry Koosman | John Curtis | Bob Apodaca | 16 | 8 | 8 |
| 1974-04-11 | @ NYN | 4 | W 8-7 | 4-1 | 2 | 0 | Bob Gibson | Tom Seaver | Mike Garman | Craig Swan | | 24 | 15 | 9 |
| 1974-04-11 | @ NYN | 5 | W 4-3 | 4-1 | 2 | 34,382 | Alan Foster | George Stone | Rich Folkers | Bob Apodaca | | 28 | 18 | 10 |
| 1974-04-12 | @ PIT | 6 | W 7-6 | 5-1 | 2 | 9,524 | Sonny Siebert | Jerry Reuss | Mike Garman | Bruce Kison | Rich Folkers | 35 | 24 | 11 |
| 1974-04-13 | @ PIT | 7 | W 6-4 | 6-1 | 1 | 7,026 | Lynn McGlothen | Jim Rooker | Lynn McGlothen | Jim Rooker | Pete Richert | 41 | 28 | 13 |
| 1974-04-14 | @ PIT | 8 | L 4-8 | 7-2 | 1 | 0 | Mike Thompson | Bob Moose | Bob Moose | Mike Thompson | | 45 | 36 | 9 |
| 1974-04-14 | @ PIT | 9 | W 6-5 | 7-2 | 1 | 11,949 | John Curtis | Ken Brett | John Curtis | Ken Brett | Rich Folkers | 51 | 41 | 10 |
| 1974-04-15 | @ PHI | 10 | L 2-3 | 7-3 | 2 | 6,713 | Alan Foster | Dick Ruthven | Dick Ruthven | Alan Foster | Mac Scarce | 53 | 44 | 9 |
| 1974-04-16 | @ PHI | 11 | L 3-10 | 7-4 | 3 | 8,107 | Bob Gibson | Steve Carlton | Steve Carlton | Bob Gibson | | 56 | 54 | 2 |
| 1974-04-17 | @ PHI | 12 | L 5-12 | 7-5 | 3 | 11,237 | Sonny Siebert | Ed Farmer | George Culver | Sonny Siebert | | 61 | 66 | -5 |
| 1974-04-18 | @ PHI | 13 | W 6-2 | 8-5 | 4 | 8,106 | Lynn McGlothen | Ron Schueler | Lynn McGlothen | Ron Schueler | | 67 | 68 | -1 |
| 1974-04-19 | vs MON | 14 | L 4-5 | 8-6 | 3 | 29,171 | John Curtis | Ernie McAnally | Ernie McAnally | John Curtis | Chuck Taylor | 71 | 73 | -2 |
| 1974-04-20 | vs MON | 15 | W 10-4 | 9-6 | 4 | 16,400 | Alan Foster | Steve Renko | Alan Foster | Steve Renko | | 81 | 77 | 4 |
| 1974-04-21 | vs MON | 16 | L 5-9 | 9-7 | 3 | 12,327 | Bob Gibson | Steve Rogers | Steve Rogers | Bob Gibson | | 86 | 86 | 0 |
| 1974-04-23 | vs HOU | 17 | W 8-2 | 10-7 | 3 | 7,188 | Sonny Siebert | Doug Konieczny | Sonny Siebert | Doug Konieczny | | 94 | 88 | 6 |
| 1974-04-24 | vs HOU | 18 | L 4-9 | 10-8 | 3 | 7,364 | Lynn McGlothen | Dave Roberts | Dave Roberts | Lynn McGlothen | | 98 | 97 | 1 |
| 1974-04-26 | vs CIN | 19 | L 3-4 | 10-9 | 2 | 28,608 | John Curtis | Don Gullett | Don Gullett | John Curtis | Pedro Borbon | 101 | 101 | 0 |
| 1974-04-27 | vs CIN | 20 | W 4-3 | 11-9 | 2 | 17,417 | Alan Foster | Fred Norman | Orlando Pena | Pedro Borbon | | 105 | 104 | 1 |
| 1974-04-28 | vs CIN | 21 | W 9-2 | 12-9 | 2 | 21,146 | Bob Gibson | Clay Kirby | Bob Gibson | Clay Kirby | | 114 | 106 | 8 |
| 1974-04-30 | vs ATL | 22 | W 7-2 | 13-9 | 1 | 15,996 | Lynn McGlothen | Ron Reed | Lynn McGlothen | Ron Reed | | 121 | 108 | 13 |
| 1974-05-01 | vs ATL | 23 | L 5-6 | 13-10 | 1 | 14,202 | John Curtis | Carl Morton | Carl Morton | Mike Garman | | 126 | 114 | 12 |
| 1974-05-03 | @ HOU | 24 | L 1-4 | 13-11 | 1 | 18,929 | Alan Foster | Claude Osteen | Claude Osteen | Alan Foster | | 127 | 118 | 9 |
| 1974-05-04 | @ HOU | 25 | L 2-3 | 13-12 | 2 | 20,600 | Sonny Siebert | Dave Roberts | Dave Roberts | Sonny Siebert | Ken Forsch | 129 | 121 | 8 |
| 1974-05-05 | @ HOU | 26 | W 3-1 | 14-12 | 1 | 17,266 | Bob Gibson | Larry Dierker | Bob Gibson | Larry Dierker | | 132 | 122 | 10 |
| 1974-05-07 | @ CIN | 27 | W 1-0 | 15-12 | 1 | 10,455 | Lynn McGlothen | Fred Norman | Lynn McGlothen | Fred Norman | | 133 | 122 | 11 |
| 1974-05-08 | @ CIN | 28 | W 2-0 | 16-12 | 1 | 9,864 | John Curtis | Don Gullett | John Curtis | Don Gullett | | 135 | 122 | 13 |
| 1974-05-10 | @ MON | 29 | L 4-5 | 16-13 | 1 | 7,105 | Alan Foster | Steve Rogers | Steve Rogers | Alan Foster | | 139 | 127 | 12 |
| 1974-05-11 | @ MON | 30 | L 1-3 | 16-14 | 2 | 11,730 | Sonny Siebert | Steve Renko | Steve Renko | Sonny Siebert | | 140 | 130 | 10 |
| 1974-05-13 | vs NYN | 31 | L 3-5 | 16-15 | 3 | 12,653 | Bob Gibson | Bob Apodaca | Bob Apodaca | Bob Gibson | Harry Parker | 143 | 135 | 8 |
| 1974-05-15 | vs NYN | 32 | W 10-1 | 17-15 | 2 | 12,096 | Lynn McGlothen | Jerry Koosman | Lynn McGlothen | Jerry Koosman | | 153 | 136 | 17 |
| 1974-05-16 | vs NYN | 33 | L 4-6 | 17-16 | 3 | 14,307 | John Curtis | George Stone | George Stone | John Curtis | | 157 | 142 | 15 |
| 1974-05-17 | vs CHN | 34 | W 9-8 | 18-16 | 2 | 21,691 | Alan Foster | Steve Stone | Orlando Pena | Bill Bonham | | 166 | 150 | 16 |
| 1974-05-18 | vs CHN | 35 | W 11-2 | 19-16 | 2 | 33,598 | Sonny Siebert | Rick Reuschel | Sonny Siebert | Rick Reuschel | | 177 | 152 | 25 |
| 1974-05-19 | vs CHN | 36 | W 6-5 | 20-16 | 1 | 29,371 | Bob Gibson | Bill Bonham | Bob Gibson | Bill Bonham | Al Hrabosky | 183 | 157 | 26 |
| 1974-05-20 | vs PHI | 37 | L 1-2 | 20-17 | 3 | 12,326 | Lynn McGlothen | Steve Carlton | Steve Carlton | Lynn McGlothen | | 184 | 159 | 25 |
| 1974-05-21 | vs PHI | 38 | L 2-4 | 20-18 | 3 | 11,481 | John Curtis | Ed Farmer | Ed Farmer | John Curtis | Mac Scarce | 186 | 163 | 23 |
| 1974-05-22 | vs PHI | 39 | L 1-7 | 20-19 | 3 | 10,587 | Alan Foster | Ron Schueler | Ron Schueler | Alan Foster | | 187 | 170 | 17 |
| 1974-05-24 | @ CHN | 40 | W 1-0 | 21-19 | 3 | 9,180 | Sonny Siebert | Rick Reuschel | Sonny Siebert | Rick Reuschel | | 188 | 170 | 18 |
| 1974-05-25 | @ CHN | 41 | L 4-5 | 21-20 | 3 | 20,237 | Bob Gibson | Bill Bonham | Bill Bonham | Bob Gibson | Dave LaRoche | 192 | 175 | 17 |
| 1974-05-26 | @ CHN | 42 | W 7-1 | 22-20 | 3 | 24,182 | Lynn McGlothen | Burt Hooton | Lynn McGlothen | Burt Hooton | | 199 | 176 | 23 |
| 1974-05-27 | vs LAN | 43 | W 7-2 | 23-20 | 3 | 22,739 | John Curtis | Andy Messersmith | John Curtis | Andy Messersmith | | 206 | 178 | 28 |
| 1974-05-28 | vs LAN | 44 | L 5-11 | 23-21 | 3 | 18,064 | Alan Foster | Don Sutton | Charlie Hough | Alan Foster | | 211 | 189 | 22 |
| 1974-05-29 | vs LAN | 45 | L 2-5 | 23-22 | 3 | 15,367 | Bob Gibson | Tommy John | Tommy John | Bob Gibson | Mike Marshall | 213 | 194 | 19 |
| 1974-05-31 | vs SDN | 46 | W 5-0 | 24-22 | 1 | 11,245 | Sonny Siebert | Steve Arlin | Sonny Siebert | Steve Arlin | | 218 | 194 | 24 |
| 1974-06-01 | vs SDN | 47 | W 3-0 | 25-22 | 1 | 47,094 | Lynn McGlothen | Randy Jones | Lynn McGlothen | Randy Jones | | 221 | 194 | 27 |
| 1974-06-02 | vs SDN | 48 | W 9-6 | 26-22 | 1 | 16,652 | John Curtis | Dave Freisleben | Orlando Pena | Vicente Romo | | 230 | 200 | 30 |
| 1974-06-04 | @ SFN | 49 | L 3-5 | 26-23 | 2 | 3,884 | Bob Gibson | Tom Bradley | Tom Bradley | Bob Gibson | Elias Sosa | 233 | 205 | 28 |
| 1974-06-05 | @ SFN | 50 | W 4-1 | 27-23 | 2 | 3,165 | Sonny Siebert | Ron Bryant | Sonny Siebert | Ron Bryant | Orlando Pena | 237 | 206 | 31 |
| 1974-06-06 | @ SFN | 51 | L 5-9 | 27-24 | 2 | 2,866 | Lynn McGlothen | Mike Caldwell | Jim Barr | Lynn McGlothen | Elias Sosa | 242 | 215 | 27 |
| 1974-06-07 | @ SDN | 52 | L 0-1 | 27-25 | 2 | 7,969 | John Curtis | Dave Freisleben | Dave Freisleben | John Curtis | | 242 | 216 | 26 |
| 1974-06-08 | @ SDN | 53 | L 3-4 | 27-26 | 2 | 27,801 | Mike Thompson | Dan Spillner | Dan Spillner | Mike Thompson | Vicente Romo | 245 | 220 | 25 |
| 1974-06-09 | @ SDN | 54 | L 5-6 | 27-27 | 2 | 13,880 | Bob Gibson | Bill Greif | Dave Tomlin | Mike Garman | Steve Arlin | 250 | 226 | 24 |
| 1974-06-10 | @ LAN | 55 | W 4-2 | 28-27 | 2 | 22,985 | Sonny Siebert | Doug Rau | Orlando Pena | Charlie Hough | | 254 | 228 | 26 |
| 1974-06-11 | @ LAN | 56 | W 1-0 | 29-27 | 2 | 28,573 | Lynn McGlothen | Andy Messersmith | Lynn McGlothen | Andy Messersmith | Al Hrabosky | 255 | 228 | 27 |
| 1974-06-12 | @ LAN | 57 | W 6-3 | 30-27 | 2 | 26,010 | John Curtis | Don Sutton | John Curtis | Don Sutton | | 261 | 231 | 30 |
| 1974-06-14 | @ ATL | 58 | L 1-6 | 30-28 | 2 | 14,336 | Bob Gibson | Roric Harrison | Roric Harrison | Bob Gibson | | 262 | 237 | 25 |
| 1974-06-15 | @ ATL | 59 | L 1-7 | 30-29 | 2 | 43,572 | Sonny Siebert | Buzz Capra | Buzz Capra | Sonny Siebert | | 263 | 244 | 19 |
| 1974-06-16 | @ ATL | 60 | W 6-3 | 31-29 | 2 | 16,417 | Lynn McGlothen | Carl Morton | Lynn McGlothen | Carl Morton | | 269 | 247 | 22 |
| 1974-06-17 | vs SFN | 61 | L 0-3 | 31-30 | 2 | 17,525 | John Curtis | Jim Barr | Jim Barr | John Curtis | | 269 | 250 | 19 |
| 1974-06-18 | vs SFN | 62 | W 3-0 | 32-30 | 2 | 17,709 | Alan Foster | Ron Bryant | Alan Foster | Ron Bryant | | 272 | 250 | 22 |
| 1974-06-19 | vs SFN | 63 | L 4-5 | 32-31 | 3 | 17,188 | Bob Gibson | John D'Acquisto | John D'Acquisto | Bob Gibson | Steve Barber | 276 | 255 | 21 |
| 1974-06-21 | vs MON | 64 | W 5-1 | 33-31 | 2 | 17,949 | Sonny Siebert | Steve Renko | Sonny Siebert | Steve Renko | | 281 | 256 | 25 |
| 1974-06-22 | vs MON | 65 | W 4-3 | 34-31 | 2 | 42,640 | Lynn McGlothen | Steve Rogers | Lynn McGlothen | Steve Rogers | Mike Garman | 285 | 259 | 26 |
| 1974-06-23 | vs MON | 66 | L 2-4 | 34-32 | 2 | 21,528 | John Curtis | Ernie McAnally | Chuck Taylor | Al Hrabosky | | 287 | 263 | 24 |
| 1974-06-24 | vs PIT | 67 | W 3-1 | 36-32 | 2 | 0 | Alan Foster | Jerry Reuss | Alan Foster | Jerry Reuss | Mike Garman | 290 | 264 | 26 |
| 1974-06-24 | vs PIT | 68 | W 4-0 | 36-32 | 2 | 25,093 | Bob Gibson | Larry Demery | Bob Gibson | Larry Demery | | 294 | 264 | 30 |
| 1974-06-25 | vs PIT | 69 | W 8-7 | 37-32 | 1 | 17,392 | Mike Thompson | Dock Ellis | Al Hrabosky | Daryl Patterson | John Curtis | 302 | 271 | 31 |
| 1974-06-26 | vs PIT | 70 | L 2-7 | 37-33 | 1 | 18,487 | Sonny Siebert | Jim Rooker | Jim Rooker | Sonny Siebert | | 304 | 278 | 26 |
| 1974-06-27 | @ NYN | 71 | W 6-1 | 38-33 | 1 | 19,952 | Lynn McGlothen | Ray Sadecki | Lynn McGlothen | Ray Sadecki | | 310 | 279 | 31 |
| 1974-06-29 | @ NYN | 72 | L 0-4 | 38-34 | 1 | 37,317 | John Curtis | Jon Matlack | Jon Matlack | John Curtis | | 310 | 283 | 27 |
| 1974-06-30 | @ NYN | 73 | W 5-2 | 40-34 | 1 | 0 | Alan Foster | Jerry Koosman | Alan Foster | Jerry Koosman | Al Hrabosky | 315 | 285 | 30 |
| 1974-06-30 | @ NYN | 74 | W 5-3 | 40-34 | 1 | 40,009 | Bob Gibson | George Stone | Orlando Pena | Tug McGraw | | 320 | 288 | 32 |
| 1974-07-02 | vs CHN | 75 | L 3-4 | 40-35 | 1 | 26,088 | Sonny Siebert | Jim Todd | Jim Todd | Sonny Siebert | Oscar Zamora | 323 | 292 | 31 |
| 1974-07-03 | vs CHN | 76 | W 5-0 | 41-35 | 1 | 29,705 | Lynn McGlothen | Rick Reuschel | Lynn McGlothen | Rick Reuschel | | 328 | 292 | 36 |
| 1974-07-04 | vs CHN | 77 | L 2-3 | 41-36 | 1 | 28,350 | John Curtis | Steve Stone | Steve Stone | John Curtis | Oscar Zamora | 330 | 295 | 35 |
| 1974-07-05 | @ CIN | 78 | W 3-2 | 42-36 | 1 | 26,066 | Alan Foster | Fred Norman | Rich Folkers | Fred Norman | Mike Garman | 333 | 297 | 36 |
| 1974-07-06 | @ CIN | 79 | W 3-1 | 43-36 | 1 | 33,989 | Bob Gibson | Clay Kirby | Bob Gibson | Clay Kirby | | 336 | 298 | 38 |
| 1974-07-07 | @ CIN | 80 | L 1-2 | 43-38 | 1 | 0 | Bob Forsch | Tom Carroll | Tom Carroll | Bob Forsch | Will McEnaney | 337 | 300 | 37 |
| 1974-07-07 | @ CIN | 81 | L 2-11 | 43-38 | 1 | 46,016 | Mike Thompson | Don Gullett | Don Gullett | Mike Thompson | | 339 | 311 | 28 |
| 1974-07-08 | @ HOU | 82 | L 1-4 | 43-39 | 1 | 12,403 | Lynn McGlothen | Tom Griffin | Tom Griffin | Lynn McGlothen | | 340 | 315 | 25 |
| 1974-07-09 | @ HOU | 83 | L 2-5 | 43-40 | 1 | 15,709 | John Curtis | Dave Roberts | Dave Roberts | John Curtis | | 342 | 320 | 22 |
| 1974-07-10 | @ HOU | 84 | L 2-3 | 43-41 | 1 | 15,126 | Alan Foster | Larry Dierker | Mike Cosgrove | Orlando Pena | | 344 | 323 | 21 |
| 1974-07-12 | vs ATL | 85 | L 3-7 | 44-42 | 2 | 0 | Bob Gibson | Roric Harrison | Joe Niekro | Bob Gibson | | 347 | 330 | 17 |
| 1974-07-12 | vs ATL | 86 | W 10-0 | 44-42 | 2 | 47,944 | Bob Forsch | Buzz Capra | Bob Forsch | Buzz Capra | | 357 | 330 | 27 |
| 1974-07-13 | vs ATL | 87 | L 1-8 | 44-43 | 2 | 41,309 | Lynn McGlothen | Ron Reed | Ron Reed | Lynn McGlothen | | 358 | 338 | 20 |
| 1974-07-14 | vs ATL | 88 | L 0-7 | 44-44 | 2 | 31,794 | Ray Bare | Phil Niekro | Phil Niekro | Ray Bare | | 358 | 345 | 13 |
| 1974-07-15 | vs CIN | 89 | L 0-3 | 44-45 | 2 | 21,316 | Alan Foster | Clay Kirby | Clay Kirby | Alan Foster | | 358 | 348 | 10 |
| 1974-07-16 | vs CIN | 90 | L 7-12 | 44-46 | 3 | 18,588 | Bob Forsch | Don Gullett | Don Gullett | Bob Forsch | | 365 | 360 | 5 |
| 1974-07-17 | vs CIN | 91 | L 4-6 | 44-47 | 3 | 28,743 | Bob Gibson | Tom Carroll | Will McEnaney | Rich Folkers | Pedro Borbon | 369 | 366 | 3 |
| 1974-07-18 | vs HOU | 92 | L 2-8 | 44-48 | 3 | 11,560 | Lynn McGlothen | Claude Osteen | Claude Osteen | Lynn McGlothen | | 371 | 374 | -3 |
| 1974-07-19 | vs HOU | 93 | L 1-5 | 44-49 | 3 | 19,230 | Ray Bare | Tom Griffin | Tom Griffin | Ray Bare | | 372 | 379 | -7 |
| 1974-07-20 | vs HOU | 94 | W 6-5 | 45-49 | 3 | 13,448 | Alan Foster | Dave Roberts | Al Hrabosky | Mike Cosgrove | | 378 | 384 | -6 |
| 1974-07-21 | vs HOU | 95 | W 9-1 | 46-49 | 2 | 15,006 | Bob Forsch | Larry Dierker | Bob Forsch | Larry Dierker | | 387 | 385 | 2 |
| 1974-07-25 | vs NYN | 96 | W 4-3 | 48-49 | 2 | 0 | Bob Gibson | Jerry Koosman | Rich Folkers | Jack Aker | | 391 | 388 | 3 |
| 1974-07-25 | vs NYN | 97 | W 4-1 | 48-49 | 2 | 27,992 | Alan Foster | Jon Matlack | Alan Foster | Jon Matlack | | 395 | 389 | 6 |
| 1974-07-26 | vs NYN | 98 | L 0-3 | 48-50 | 2 | 20,783 | Lynn McGlothen | Tom Seaver | Tom Seaver | Lynn McGlothen | | 395 | 392 | 3 |
| 1974-07-27 | @ CHN | 99 | W 3-2 | 49-50 | 2 | 29,228 | Bob Forsch | Bill Bonham | Bob Forsch | Bill Bonham | | 398 | 394 | 4 |
| 1974-07-28 | @ CHN | 100 | W 5-4 | 50-50 | 2 | 30,425 | Sonny Siebert | Steve Stone | Al Hrabosky | Ken Frailing | Mike Garman | 403 | 398 | 5 |
| 1974-07-29 | @ CHN | 101 | W 11-4 | 51-50 | 2 | 18,689 | John Curtis | Burt Hooton | John Curtis | Burt Hooton | | 414 | 402 | 12 |
| 1974-07-30 | @ PHI | 102 | W 4-3 | 52-50 | 2 | 33,382 | Alan Foster | Jim Lonborg | Al Hrabosky | Jesus Hernaiz | | 418 | 405 | 13 |
| 1974-07-31 | @ PHI | 103 | W 9-8 | 53-50 | 2 | 33,431 | Bob Gibson | Dick Ruthven | Bob Gibson | Dick Ruthven | Al Hrabosky | 427 | 413 | 14 |
| 1974-08-01 | @ PIT | 104 | W 5-2 | 54-50 | 2 | 17,318 | Lynn McGlothen | Ken Brett | Rich Folkers | Dave Giusti | | 432 | 415 | 17 |
| 1974-08-02 | @ PIT | 105 | L 2-3 | 54-51 | 2 | 19,385 | Bob Forsch | Larry Demery | Ramon Hernandez | Orlando Pena | | 434 | 418 | 16 |
| 1974-08-03 | vs PHI | 106 | W 4-3 | 55-51 | 1 | 36,053 | Sonny Siebert | Jim Lonborg | Mike Garman | Jim Lonborg | | 438 | 421 | 17 |
| 1974-08-04 | vs PHI | 107 | L 1-6 | 56-52 | 1 | 0 | Alan Foster | Ron Schueler | Ron Schueler | Alan Foster | | 439 | 427 | 12 |
| 1974-08-04 | vs PHI | 108 | W 11-0 | 56-52 | 1 | 48,245 | John Curtis | Dick Ruthven | John Curtis | Dick Ruthven | | 450 | 427 | 23 |
| 1974-08-05 | vs PHI | 109 | W 3-2 | 57-52 | 1 | 33,476 | Bob Gibson | Wayne Twitchell | Mike Garman | Pete Richert | | 453 | 429 | 24 |
| 1974-08-06 | @ MON | 110 | W 5-4 | 59-52 | 1 | 0 | Lynn McGlothen | Mike Torrez | Lynn McGlothen | Mike Torrez | Al Hrabosky | 458 | 433 | 25 |
| 1974-08-06 | @ MON | 111 | W 9-4 | 59-52 | 1 | 21,352 | Ray Bare | Steve Rogers | Rich Folkers | Steve Rogers | | 467 | 437 | 30 |
| 1974-08-07 | @ MON | 112 | L 5-7 | 59-53 | 1 | 19,023 | Bob Forsch | Steve Renko | Steve Renko | Bob Forsch | | 472 | 444 | 28 |
| 1974-08-08 | @ MON | 113 | L 2-3 | 59-54 | 1 | 17,205 | Sonny Siebert | Tom Walker | Don Carrithers | John Curtis | | 474 | 447 | 27 |
| 1974-08-09 | vs LAN | 114 | W 5-3 | 60-54 | 1 | 29,899 | Alan Foster | Geoff Zahn | Alan Foster | Geoff Zahn | Al Hrabosky | 479 | 450 | 29 |
| 1974-08-10 | vs LAN | 115 | L 2-6 | 60-55 | 1 | 45,293 | Bob Gibson | Doug Rau | Doug Rau | Bob Gibson | Mike Marshall | 481 | 456 | 25 |
| 1974-08-11 | vs LAN | 116 | L 1-3 | 60-56 | 1 | 36,914 | Lynn McGlothen | Don Sutton | Don Sutton | Lynn McGlothen | | 482 | 459 | 23 |
| 1974-08-12 | vs SDN | 117 | W 6-5 | 61-56 | 1 | 16,493 | John Curtis | Bill Greif | Al Hrabosky | Bill Laxton | | 488 | 464 | 24 |
| 1974-08-13 | vs SDN | 118 | L 1-2 | 61-57 | 1 | 17,480 | Sonny Siebert | Vicente Romo | Lowell Palmer | Sonny Siebert | | 489 | 466 | 23 |
| 1974-08-14 | vs SDN | 119 | W 5-1 | 62-57 | 1 | 16,427 | Alan Foster | Randy Jones | Alan Foster | Randy Jones | | 494 | 467 | 27 |
| 1974-08-16 | vs SFN | 120 | W 2-1 | 63-57 | 1 | 28,723 | Bob Gibson | John D'Acquisto | Bob Gibson | John D'Acquisto | | 496 | 468 | 28 |
| 1974-08-17 | vs SFN | 121 | W 5-3 | 64-57 | 1 | 32,128 | Lynn McGlothen | Mike Caldwell | Mike Garman | Randy Moffitt | | 501 | 471 | 30 |
| 1974-08-18 | vs SFN | 122 | W 4-1 | 65-57 | 1 | 30,208 | John Curtis | Tom Bradley | John Curtis | Tom Bradley | | 505 | 472 | 33 |
| 1974-08-19 | @ ATL | 123 | L 6-11 | 65-58 | 1 | 7,104 | Claude Osteen | Carl Morton | Joe Niekro | Claude Osteen | Max Leon | 511 | 483 | 28 |
| 1974-08-20 | @ ATL | 124 | L 6-8 | 65-59 | 1 | 8,190 | Alan Foster | Phil Niekro | Phil Niekro | Alan Foster | Tom House | 517 | 491 | 26 |
| 1974-08-21 | @ ATL | 125 | L 4-5 | 65-60 | 1 | 10,118 | Bob Gibson | Buzz Capra | Buzz Capra | Bob Gibson | | 521 | 496 | 25 |
| 1974-08-23 | @ LAN | 126 | W 2-1 | 66-60 | 1 | 40,993 | Lynn McGlothen | Doug Rau | Lynn McGlothen | Mike Marshall | Mike Garman | 523 | 497 | 26 |
| 1974-08-24 | @ LAN | 127 | L 0-3 | 66-61 | 1 | 41,199 | John Curtis | Don Sutton | Don Sutton | John Curtis | | 523 | 500 | 23 |
| 1974-08-25 | @ LAN | 128 | L 3-9 | 66-62 | 2 | 38,986 | Alan Foster | Andy Messersmith | Andy Messersmith | Alan Foster | Mike Marshall | 526 | 509 | 17 |
| 1974-08-27 | @ SDN | 129 | L 1-3 | 66-63 | 2 | 9,782 | Bob Gibson | Dan Spillner | Dan Spillner | Bob Gibson | | 527 | 512 | 15 |
| 1974-08-28 | @ SDN | 130 | W 5-1 | 67-63 | 2 | 9,641 | Lynn McGlothen | Bill Greif | Lynn McGlothen | Bill Greif | | 532 | 513 | 19 |
| 1974-08-29 | @ SDN | 131 | W 3-1 | 68-63 | 2 | 6,042 | John Curtis | Randy Jones | John Curtis | Larry Hardy | | 535 | 514 | 21 |
| 1974-08-30 | @ SFN | 132 | L 2-8 | 68-64 | 2 | 3,111 | Sonny Siebert | Mike Caldwell | Mike Caldwell | Sonny Siebert | | 537 | 522 | 15 |
| 1974-08-31 | @ SFN | 133 | L 2-3 | 68-65 | 2 | 14,356 | Bob Forsch | John D'Acquisto | John D'Acquisto | Bob Forsch | John Morris | 539 | 525 | 14 |
| 1974-09-01 | @ SFN | 134 | W 8-1 | 69-65 | 2 | 6,842 | Bob Gibson | Ed Halicki | Bob Gibson | Ed Halicki | | 547 | 526 | 21 |
| 1974-09-03 | vs MON | 135 | W 5-1 | 71-65 | 2 | 0 | Lynn McGlothen | Tom Walker | Lynn McGlothen | Tom Walker | | 552 | 527 | 25 |
| 1974-09-03 | vs MON | 136 | W 8-4 | 71-65 | 2 | 15,366 | John Curtis | Steve Rogers | Mike Garman | Steve Rogers | | 560 | 531 | 29 |
| 1974-09-04 | vs MON | 137 | W 5-4 | 72-65 | 2 | 13,288 | Alan Foster | Dennis Blair | Rich Folkers | Chuck Taylor | Al Hrabosky | 565 | 535 | 30 |
| 1974-09-06 | vs NYN | 138 | W 3-0 | 73-65 | 2 | 21,832 | Bob Forsch | Jerry Koosman | Bob Forsch | Jerry Koosman | | 568 | 535 | 33 |
| 1974-09-07 | vs NYN | 139 | W 2-1 | 74-65 | 2 | 36,007 | Bob Gibson | Jon Matlack | Bob Gibson | Jon Matlack | | 570 | 536 | 34 |
| 1974-09-08 | vs NYN | 140 | L 3-5 | 74-66 | 2 | 34,304 | Lynn McGlothen | Tom Seaver | Tom Seaver | Lynn McGlothen | | 573 | 541 | 32 |
| 1974-09-09 | vs PHI | 141 | L 0-2 | 74-67 | 2 | 27,801 | John Curtis | Jim Lonborg | Jim Lonborg | John Curtis | | 573 | 543 | 30 |
| 1974-09-10 | vs PHI | 142 | L 2-8 | 74-68 | 2 | 27,285 | Alan Foster | Dick Ruthven | Dick Ruthven | Alan Foster | | 575 | 551 | 24 |
| 1974-09-11 | @ NYN | 143 | W 4-3 | 75-68 | 2 | 13,460 | Bob Forsch | Jerry Koosman | Sonny Siebert | Hank Webb | | 579 | 554 | 25 |
| 1974-09-12 | @ NYN | 144 | W 12-5 | 76-68 | 2 | 11,747 | Bob Gibson | Jon Matlack | Bob Gibson | Jon Matlack | Al Hrabosky | 591 | 559 | 32 |
| 1974-09-13 | @ PHI | 145 | W 7-3 | 77-68 | 2 | 35,290 | Lynn McGlothen | Jim Lonborg | Ray Bare | Jesus Hernaiz | | 598 | 562 | 36 |
| 1974-09-14 | @ PHI | 146 | W 9-2 | 78-68 | 1 | 40,426 | John Curtis | Dick Ruthven | John Curtis | Dick Ruthven | | 607 | 564 | 43 |
| 1974-09-15 | @ PHI | 147 | W 3-1 | 79-68 | 1 | 30,142 | Bob Forsch | Steve Carlton | Bob Forsch | Steve Carlton | Al Hrabosky | 610 | 565 | 45 |
| 1974-09-17 | @ PIT | 148 | W 2-1 | 80-68 | 1 | 21,458 | Bob Gibson | Jerry Reuss | Al Hrabosky | Jerry Reuss | | 612 | 566 | 46 |
| 1974-09-18 | @ PIT | 149 | L 1-4 | 80-69 | 1 | 18,126 | Lynn McGlothen | Jim Rooker | Jim Rooker | Lynn McGlothen | | 613 | 570 | 43 |
| 1974-09-19 | @ PIT | 150 | L 6-8 | 80-70 | 1 | 19,844 | John Curtis | Bruce Kison | Ramon Hernandez | Rich Folkers | Dave Giusti | 619 | 578 | 41 |
| 1974-09-20 | vs CHN | 151 | W 5-2 | 81-70 | 1 | 25,335 | Bob Forsch | Bill Bonham | Bob Forsch | Bill Bonham | Mike Garman | 624 | 580 | 44 |
| 1974-09-21 | vs CHN | 152 | L 4-19 | 81-71 | 1 | 31,980 | Claude Osteen | Tom Dettore | Tom Dettore | Claude Osteen | | 628 | 599 | 29 |
| 1974-09-22 | vs CHN | 153 | W 6-5 | 82-71 | 1 | 43,267 | Bob Gibson | Steve Stone | Al Hrabosky | Dave LaRoche | | 634 | 604 | 30 |
| 1974-09-23 | vs PIT | 154 | L 0-1 | 82-72 | 1 | 33,525 | Lynn McGlothen | Jim Rooker | Jim Rooker | Lynn McGlothen | Dave Giusti | 634 | 605 | 29 |
| 1974-09-24 | vs PIT | 155 | L 3-7 | 82-73 | 2 | 37,197 | John Curtis | Bruce Kison | Bruce Kison | John Curtis | | 637 | 612 | 25 |
| 1974-09-25 | vs PIT | 156 | W 13-12 | 83-73 | 1 | 41,345 | Bob Forsch | Ken Brett | Mike Garman | Jim Minshall | | 650 | 624 | 26 |
| 1974-09-27 | @ CHN | 157 | W 10-4 | 84-73 | 2 | 4,904 | Bob Gibson | Tom Dettore | Bob Gibson | Tom Dettore | | 660 | 628 | 32 |
| 1974-09-28 | @ CHN | 158 | L 3-8 | 84-74 | 2 | 13,867 | Lynn McGlothen | Rick Reuschel | Dave LaRoche | Lynn McGlothen | | 663 | 636 | 27 |
| 1974-09-29 | @ CHN | 159 | W 7-3 | 85-74 | 2 | 17,722 | John Curtis | Steve Stone | John Curtis | Steve Stone | | 670 | 639 | 31 |
| 1974-09-30 | @ MON | 160 | W 5-1 | 86-74 | 2 | 5,337 | Bob Forsch | Steve Rogers | Bob Forsch | Steve Rogers | | 675 | 640 | 35 |
| 1974-10-01 | @ MON | 161 | L 2-3 | 86-75 | 2 | 5,112 | Bob Gibson | Mike Torrez | Dale Murray | Bob Gibson | | 677 | 643 | 34 |