| 1974-04-05 | vs HOU | 1 | W 5-1 | 1-0 | 3 | 17,527 | Tom Bradley | Dave Roberts | Tom Bradley | Dave Roberts | | 5 | 1 | 4 |
| 1974-04-06 | vs HOU | 2 | W 3-2 | 2-0 | 3 | 16,727 | Mike Caldwell | Tom Griffin | Mike Caldwell | Tom Griffin | Randy Moffitt | 8 | 3 | 5 |
| 1974-04-07 | vs HOU | 3 | W 8-4 | 3-0 | 2 | 10,341 | Jim Willoughby | Claude Osteen | Jim Willoughby | Claude Osteen | Jim Barr | 16 | 7 | 9 |
| 1974-04-08 | vs CIN | 4 | W 4-3 | 4-0 | 1 | 4,729 | John D'Acquisto | Roger Nelson | John D'Acquisto | Roger Nelson | Randy Moffitt | 20 | 10 | 10 |
| 1974-04-09 | vs CIN | 5 | L 3-6 | 4-1 | 2 | 8,426 | Tom Bradley | Jack Billingham | Jack Billingham | Tom Bradley | Pedro Borbon | 23 | 16 | 7 |
| 1974-04-10 | vs CIN | 6 | W 4-3 | 5-1 | 2 | 8,456 | Mike Caldwell | Don Gullett | Mike Caldwell | Don Gullett | | 27 | 19 | 8 |
| 1974-04-12 | @ SDN | 7 | L 2-3 | 5-2 | 1 | 11,870 | Jim Willoughby | Steve Arlin | Steve Arlin | Jim Willoughby | Vicente Romo | 29 | 22 | 7 |
| 1974-04-13 | @ SDN | 8 | W 3-2 | 6-2 | 1 | 15,479 | John D'Acquisto | Jim McAndrew | John D'Acquisto | Jim McAndrew | Randy Moffitt | 32 | 24 | 8 |
| 1974-04-14 | @ SDN | 9 | L 5-6 | 6-3 | 2 | 9,562 | Tom Bradley | Bill Greif | Rich Troedson | Jim Barr | Vicente Romo | 37 | 30 | 7 |
| 1974-04-15 | @ HOU | 10 | L 1-3 | 6-4 | 2 | 8,713 | Mike Caldwell | Larry Dierker | Larry Dierker | Mike Caldwell | | 38 | 33 | 5 |
| 1974-04-16 | @ HOU | 11 | L 0-4 | 6-5 | 4 | 8,191 | Jim Willoughby | Tom Griffin | Tom Griffin | Jim Willoughby | | 38 | 37 | 1 |
| 1974-04-17 | @ HOU | 12 | L 2-3 | 6-6 | 4 | 10,038 | John D'Acquisto | Claude Osteen | Claude Osteen | John D'Acquisto | Ken Forsch | 40 | 40 | 0 |
| 1974-04-18 | @ HOU | 13 | W 5-2 | 7-6 | 4 | 8,074 | Tom Bradley | Doug Konieczny | Tom Bradley | Doug Konieczny | | 45 | 42 | 3 |
| 1974-04-19 | @ LAN | 14 | W 5-4 | 8-6 | 3 | 45,516 | Mike Caldwell | Don Sutton | Mike Caldwell | Don Sutton | Randy Moffitt | 50 | 46 | 4 |
| 1974-04-20 | @ LAN | 15 | L 2-4 | 8-7 | 4 | 33,707 | Jim Willoughby | Tommy John | Tommy John | Jim Willoughby | | 52 | 50 | 2 |
| 1974-04-21 | @ LAN | 16 | W 6-4 | 9-7 | 3 | 41,399 | John D'Acquisto | Andy Messersmith | Randy Moffitt | Mike Marshall | | 58 | 54 | 4 |
| 1974-04-23 | vs MON | 17 | L 4-8 | 9-8 | 4 | 2,627 | Tom Bradley | Mike Torrez | Mike Torrez | Tom Bradley | Tom Walker | 62 | 62 | 0 |
| 1974-04-25 | vs MON | 18 | W 8-2 | 10-8 | 4 | 1,789 | Mike Caldwell | Ernie McAnally | Mike Caldwell | Ernie McAnally | | 70 | 64 | 6 |
| 1974-04-26 | vs NYN | 19 | L 0-6 | 10-9 | 4 | 8,210 | Ron Bryant | Tom Seaver | Tom Seaver | Ron Bryant | | 70 | 70 | 0 |
| 1974-04-27 | vs NYN | 20 | W 11-3 | 11-9 | 4 | 9,727 | John D'Acquisto | Craig Swan | Elias Sosa | Craig Swan | | 81 | 73 | 8 |
| 1974-04-28 | vs NYN | 21 | L 0-6 | 11-11 | 5 | 0 | Tom Bradley | Jon Matlack | Jon Matlack | Tom Bradley | | 81 | 79 | 2 |
| 1974-04-28 | vs NYN | 22 | L 4-6 | 11-11 | 5 | 18,970 | Charlie Williams | Harry Parker | Harry Parker | Randy Moffitt | Bob Miller | 85 | 85 | 0 |
| 1974-04-30 | vs PHI | 23 | L 5-6 | 11-12 | 5 | 2,188 | Mike Caldwell | Dick Ruthven | Frank Linzy | Randy Moffitt | Eddie Watt | 90 | 91 | -1 |
| 1974-05-01 | vs PHI | 24 | W 13-8 | 12-12 | 5 | 2,179 | Ron Bryant | Steve Carlton | Charlie Williams | Steve Carlton | | 103 | 99 | 4 |
| 1974-05-04 | @ MON | 25 | L 2-4 | 12-13 | 4 | 12,116 | John D'Acquisto | Steve Rogers | Steve Rogers | John D'Acquisto | | 105 | 103 | 2 |
| 1974-05-05 | @ MON | 26 | W 4-0 | 14-13 | 4 | 0 | Mike Caldwell | Steve Renko | Mike Caldwell | Steve Renko | | 109 | 103 | 6 |
| 1974-05-05 | @ MON | 27 | W 8-1 | 14-13 | 4 | 16,101 | Tom Bradley | Mike Torrez | Tom Bradley | Mike Torrez | | 117 | 104 | 13 |
| 1974-05-07 | @ NYN | 28 | W 4-3 | 16-13 | 3 | 0 | Ron Bryant | Tom Seaver | Elias Sosa | Tom Seaver | | 121 | 107 | 14 |
| 1974-05-07 | @ NYN | 29 | W 3-0 | 16-13 | 3 | 15,352 | Jim Barr | George Stone | Jim Barr | George Stone | Randy Moffitt | 124 | 107 | 17 |
| 1974-05-08 | @ NYN | 30 | L 2-4 | 16-14 | 3 | 13,421 | John D'Acquisto | Jon Matlack | Jon Matlack | John D'Acquisto | | 126 | 111 | 15 |
| 1974-05-10 | @ ATL | 31 | W 5-4 | 17-14 | 3 | 5,879 | Mike Caldwell | Phil Niekro | Elias Sosa | Buzz Capra | | 131 | 115 | 16 |
| 1974-05-11 | @ ATL | 32 | W 8-7 | 18-14 | 3 | 7,271 | Tom Bradley | Ron Reed | Tom Bradley | Ron Reed | Randy Moffitt | 139 | 122 | 17 |
| 1974-05-12 | @ ATL | 33 | L 1-5 | 19-15 | 3 | 0 | Ron Bryant | Carl Morton | Carl Morton | Ron Bryant | | 140 | 127 | 13 |
| 1974-05-12 | @ ATL | 34 | W 6-2 | 19-15 | 3 | 11,076 | Jim Barr | Gary Gentry | Randy Moffitt | Danny Frisella | | 146 | 129 | 17 |
| 1974-05-13 | @ CIN | 35 | L 1-4 | 19-16 | 3 | 12,586 | John D'Acquisto | Don Gullett | Don Gullett | John D'Acquisto | Pedro Borbon | 147 | 133 | 14 |
| 1974-05-14 | @ CIN | 36 | W 4-0 | 20-16 | 2 | 16,331 | Mike Caldwell | Jack Billingham | Mike Caldwell | Jack Billingham | | 151 | 133 | 18 |
| 1974-05-15 | @ CIN | 37 | L 3-4 | 20-17 | 2 | 14,227 | Tom Bradley | Roger Nelson | Roger Nelson | Tom Bradley | Pedro Borbon | 154 | 137 | 17 |
| 1974-05-17 | vs SDN | 38 | L 3-7 | 20-18 | 3 | 3,099 | Ron Bryant | Randy Jones | Randy Jones | Ron Bryant | Vicente Romo | 157 | 144 | 13 |
| 1974-05-18 | vs SDN | 39 | W 4-2 | 21-18 | 3 | 15,517 | Jim Barr | Steve Arlin | Elias Sosa | Steve Arlin | Randy Moffitt | 161 | 146 | 15 |
| 1974-05-19 | vs SDN | 40 | W 8-2 | 22-19 | 3 | 0 | Mike Caldwell | Bill Greif | Mike Caldwell | Bill Greif | | 169 | 148 | 21 |
| 1974-05-19 | vs SDN | 41 | L 7-10 | 22-19 | 3 | 10,876 | Tom Bradley | Jim McAndrew | Larry Hardy | Jim Willoughby | | 176 | 158 | 18 |
| 1974-05-21 | vs ATL | 42 | L 1-4 | 23-20 | 3 | 0 | John D'Acquisto | Carl Morton | Carl Morton | John D'Acquisto | | 177 | 162 | 15 |
| 1974-05-21 | vs ATL | 43 | W 5-4 | 23-20 | 3 | 8,809 | Ron Bryant | Roric Harrison | Ron Bryant | Roric Harrison | Randy Moffitt | 182 | 166 | 16 |
| 1974-05-22 | vs ATL | 44 | L 2-6 | 23-21 | 3 | 5,019 | Jim Barr | Phil Niekro | Phil Niekro | Jim Barr | | 184 | 172 | 12 |
| 1974-05-23 | vs LAN | 45 | W 7-6 | 24-21 | 2 | 8,338 | Mike Caldwell | Andy Messersmith | Elias Sosa | Mike Marshall | Randy Moffitt | 191 | 178 | 13 |
| 1974-05-24 | vs LAN | 46 | W 9-7 | 25-21 | 2 | 16,860 | Tom Bradley | Don Sutton | Tom Bradley | Don Sutton | Randy Moffitt | 200 | 185 | 15 |
| 1974-05-25 | vs LAN | 47 | L 5-9 | 25-22 | 3 | 16,392 | Ron Bryant | Tommy John | Tommy John | Ron Bryant | | 205 | 194 | 11 |
| 1974-05-26 | vs LAN | 48 | L 5-9 | 25-23 | 3 | 22,526 | Jim Barr | Doug Rau | Doug Rau | Jim Barr | Mike Marshall | 210 | 203 | 7 |
| 1974-05-27 | @ CHN | 49 | L 4-12 | 25-24 | 4 | 18,161 | Mike Caldwell | Ken Frailing | Ken Frailing | Mike Caldwell | | 214 | 215 | -1 |
| 1974-05-29 | @ CHN | 50 | W 5-4 | 26-24 | 4 | 8,632 | John D'Acquisto | Rick Reuschel | John D'Acquisto | Rick Reuschel | Randy Moffitt | 219 | 219 | 0 |
| 1974-05-30 | @ CHN | 51 | L 3-5 | 26-25 | 5 | 12,630 | Tom Bradley | Bill Bonham | Bill Bonham | Elias Sosa | | 222 | 224 | -2 |
| 1974-05-31 | @ PHI | 52 | W 6-2 | 27-25 | 5 | 23,513 | Ron Bryant | Ron Schueler | Ron Bryant | Ron Schueler | Randy Moffitt | 228 | 226 | 2 |
| 1974-06-01 | @ PHI | 53 | L 2-6 | 27-26 | 5 | 20,167 | Mike Caldwell | Jim Lonborg | Jim Lonborg | Mike Caldwell | | 230 | 232 | -2 |
| 1974-06-02 | @ PHI | 54 | L 3-4 | 27-27 | 5 | 12,280 | John D'Acquisto | Dick Ruthven | Frank Linzy | Randy Moffitt | | 233 | 236 | -3 |
| 1974-06-04 | vs SLN | 55 | W 5-3 | 28-27 | 5 | 3,884 | Tom Bradley | Bob Gibson | Tom Bradley | Bob Gibson | Elias Sosa | 238 | 239 | -1 |
| 1974-06-05 | vs SLN | 56 | L 1-4 | 28-28 | 5 | 3,165 | Ron Bryant | Sonny Siebert | Sonny Siebert | Ron Bryant | Orlando Pena | 239 | 243 | -4 |
| 1974-06-06 | vs SLN | 57 | W 9-5 | 29-28 | 5 | 2,866 | Mike Caldwell | Lynn McGlothen | Jim Barr | Lynn McGlothen | Elias Sosa | 248 | 248 | 0 |
| 1974-06-07 | vs PIT | 58 | W 6-2 | 30-28 | 5 | 3,845 | John D'Acquisto | Larry Demery | John D'Acquisto | Larry Demery | | 254 | 250 | 4 |
| 1974-06-08 | vs PIT | 59 | L 2-5 | 30-29 | 5 | 9,138 | Tom Bradley | Dock Ellis | Dock Ellis | Tom Bradley | Bruce Kison | 256 | 255 | 1 |
| 1974-06-09 | vs PIT | 60 | L 1-14 | 30-30 | 5 | 8,786 | Ron Bryant | Jerry Reuss | Jerry Reuss | Ron Bryant | | 257 | 269 | -12 |
| 1974-06-11 | vs CHN | 61 | L 4-7 | 30-31 | 5 | 3,331 | John D'Acquisto | Ken Frailing | Ken Frailing | John D'Acquisto | Horacio Pina | 261 | 276 | -15 |
| 1974-06-12 | vs CHN | 62 | L 1-10 | 30-32 | 5 | 2,541 | Tom Bradley | Rick Reuschel | Rick Reuschel | Tom Bradley | | 262 | 286 | -24 |
| 1974-06-13 | vs CHN | 63 | W 1-0 | 31-32 | 5 | 2,342 | Jim Barr | Bill Bonham | Jim Barr | Bill Bonham | | 263 | 286 | -23 |
| 1974-06-14 | @ PIT | 64 | L 2-4 | 31-33 | 5 | 18,588 | Ron Bryant | Dock Ellis | Dock Ellis | Ron Bryant | | 265 | 290 | -25 |
| 1974-06-15 | @ PIT | 65 | L 2-3 | 31-34 | 5 | 13,571 | John D'Acquisto | Jerry Reuss | Daryl Patterson | Elias Sosa | | 267 | 293 | -26 |
| 1974-06-16 | @ PIT | 66 | L 3-4 | 31-35 | 5 | 12,606 | Tom Bradley | Jim Rooker | Jim Rooker | Tom Bradley | | 270 | 297 | -27 |
| 1974-06-17 | @ SLN | 67 | W 3-0 | 32-35 | 5 | 17,525 | Jim Barr | John Curtis | Jim Barr | John Curtis | | 273 | 297 | -24 |
| 1974-06-18 | @ SLN | 68 | L 0-3 | 32-36 | 5 | 17,709 | Ron Bryant | Alan Foster | Alan Foster | Ron Bryant | | 273 | 300 | -27 |
| 1974-06-19 | @ SLN | 69 | W 5-4 | 33-36 | 5 | 17,188 | John D'Acquisto | Bob Gibson | John D'Acquisto | Bob Gibson | Steve Barber | 278 | 304 | -26 |
| 1974-06-21 | @ LAN | 70 | L 3-4 | 33-37 | 5 | 43,765 | Randy Moffitt | Andy Messersmith | Mike Marshall | Elias Sosa | | 281 | 308 | -27 |
| 1974-06-22 | @ LAN | 71 | L 2-3 | 33-38 | 5 | 45,538 | Jim Barr | Don Sutton | Mike Marshall | Elias Sosa | | 283 | 311 | -28 |
| 1974-06-23 | @ LAN | 72 | L 3-4 | 33-39 | 5 | 52,563 | John D'Acquisto | Tommy John | Mike Marshall | Steve Barber | | 286 | 315 | -29 |
| 1974-06-24 | @ SDN | 73 | L 1-2 | 33-40 | 5 | 27,125 | Ron Bryant | Dan Spillner | Dan Spillner | Ron Bryant | Vicente Romo | 287 | 317 | -30 |
| 1974-06-25 | @ SDN | 74 | L 1-3 | 33-41 | 5 | 10,860 | Charlie Williams | Lowell Palmer | Lowell Palmer | Charlie Williams | | 288 | 320 | -32 |
| 1974-06-26 | @ SDN | 75 | L 0-4 | 33-42 | 5 | 13,092 | Jim Barr | Bill Greif | Bill Greif | Jim Barr | | 288 | 324 | -36 |
| 1974-06-27 | @ SDN | 76 | W 4-2 | 34-42 | 5 | 11,295 | John D'Acquisto | Randy Jones | John D'Acquisto | Randy Jones | | 292 | 326 | -34 |
| 1974-06-28 | vs LAN | 77 | L 3-11 | 34-43 | 5 | 11,210 | Ron Bryant | Tommy John | Tommy John | Ron Bryant | Mike Marshall | 295 | 337 | -42 |
| 1974-06-29 | vs LAN | 78 | L 4-6 | 34-44 | 5 | 20,737 | Charlie Williams | Doug Rau | Doug Rau | Charlie Williams | Charlie Hough | 299 | 343 | -44 |
| 1974-06-30 | vs LAN | 79 | L 3-5 | 34-45 | 5 | 18,360 | Jim Barr | Andy Messersmith | Andy Messersmith | Tom Bradley | | 302 | 348 | -46 |
| 1974-07-02 | vs SDN | 80 | L 1-5 | 34-46 | 6 | 2,297 | John D'Acquisto | Randy Jones | Randy Jones | John D'Acquisto | | 303 | 353 | -50 |
| 1974-07-03 | vs SDN | 81 | W 3-2 | 35-46 | 5 | 3,489 | Ron Bryant | Dave Freisleben | Randy Moffitt | Vicente Romo | | 306 | 355 | -49 |
| 1974-07-04 | vs SDN | 82 | W 9-2 | 36-46 | 5 | 5,718 | Tom Bradley | Dan Spillner | Tom Bradley | Dan Spillner | | 315 | 357 | -42 |
| 1974-07-05 | @ NYN | 83 | L 2-3 | 36-47 | 5 | 19,343 | Jim Barr | Jerry Koosman | Jerry Koosman | Jim Barr | | 317 | 360 | -43 |
| 1974-07-06 | @ NYN | 84 | W 5-2 | 37-47 | 5 | 23,763 | John D'Acquisto | George Stone | John D'Acquisto | George Stone | Randy Moffitt | 322 | 362 | -40 |
| 1974-07-07 | @ NYN | 85 | L 0-6 | 37-48 | 5 | 27,190 | Ron Bryant | Tom Seaver | Tom Seaver | Ron Bryant | Bob Apodaca | 322 | 368 | -46 |
| 1974-07-08 | @ MON | 86 | W 5-4 | 38-48 | 5 | 13,523 | Ed Halicki | Steve Rogers | Randy Moffitt | Steve Rogers | | 327 | 372 | -45 |
| 1974-07-09 | @ MON | 87 | L 4-5 | 38-49 | 5 | 10,037 | Tom Bradley | Dennis Blair | Dennis Blair | Tom Bradley | John Montague | 331 | 377 | -46 |
| 1974-07-10 | @ MON | 88 | W 4-2 | 39-49 | 5 | 15,112 | Jim Barr | Steve Renko | Jim Barr | Steve Renko | | 335 | 379 | -44 |
| 1974-07-12 | vs PHI | 89 | L 2-6 | 39-50 | 5 | 3,329 | John D'Acquisto | Dick Ruthven | Dick Ruthven | Elias Sosa | | 337 | 385 | -48 |
| 1974-07-13 | vs PHI | 90 | W 13-3 | 40-50 | 5 | 4,720 | Mike Caldwell | Jim Lonborg | Mike Caldwell | Jim Lonborg | | 350 | 388 | -38 |
| 1974-07-14 | vs PHI | 91 | L 2-5 | 40-52 | 5 | 0 | Ed Halicki | Steve Carlton | Steve Carlton | Ed Halicki | | 352 | 393 | -41 |
| 1974-07-14 | vs PHI | 92 | L 4-7 | 40-52 | 5 | 9,239 | Tom Bradley | Wayne Twitchell | Wayne Twitchell | Tom Bradley | | 356 | 400 | -44 |
| 1974-07-16 | vs NYN | 93 | W 9-4 | 41-52 | 5 | 3,976 | Jim Barr | Jerry Koosman | Jim Barr | Jerry Koosman | | 365 | 404 | -39 |
| 1974-07-17 | vs NYN | 94 | W 6-2 | 42-52 | 5 | 10,016 | John D'Acquisto | Bob Apodaca | John D'Acquisto | Bob Apodaca | | 371 | 406 | -35 |
| 1974-07-19 | vs MON | 95 | W 6-2 | 43-52 | 5 | 3,121 | Mike Caldwell | Mike Torrez | Mike Caldwell | Mike Torrez | Randy Moffitt | 377 | 408 | -31 |
| 1974-07-20 | vs MON | 96 | L 2-3 | 43-53 | 5 | 5,141 | Ed Halicki | Dennis Blair | Dennis Blair | Ed Halicki | | 379 | 411 | -32 |
| 1974-07-21 | vs MON | 97 | W 4-0 | 45-53 | 5 | 0 | Jim Barr | Steve Renko | Jim Barr | Steve Renko | | 383 | 411 | -28 |
| 1974-07-21 | vs MON | 98 | W 2-0 | 45-53 | 5 | 8,007 | John D'Acquisto | Steve Rogers | John D'Acquisto | Steve Rogers | Elias Sosa | 385 | 411 | -26 |
| 1974-07-25 | @ CIN | 99 | L 13-14 | 45-55 | 5 | 0 | Mike Caldwell | Clay Kirby | Jack Billingham | Randy Moffitt | | 398 | 425 | -27 |
| 1974-07-25 | @ CIN | 100 | L 0-5 | 45-55 | 5 | 40,025 | Ed Halicki | Fred Norman | Fred Norman | Ed Halicki | | 398 | 430 | -32 |
| 1974-07-26 | @ CIN | 101 | W 5-4 | 46-55 | 5 | 30,094 | Jim Barr | Don Gullett | Jim Barr | Don Gullett | Elias Sosa | 403 | 434 | -31 |
| 1974-07-27 | @ HOU | 102 | L 3-11 | 46-56 | 5 | 21,563 | John D'Acquisto | Larry Dierker | Larry Dierker | John D'Acquisto | | 406 | 445 | -39 |
| 1974-07-28 | @ HOU | 103 | L 2-3 | 46-57 | 5 | 17,958 | Charlie Williams | Dave Roberts | Jim York | Randy Moffitt | | 408 | 448 | -40 |
| 1974-07-29 | @ HOU | 104 | W 7-2 | 47-57 | 5 | 15,491 | Ed Halicki | Claude Osteen | Ed Halicki | Claude Osteen | | 415 | 450 | -35 |
| 1974-07-30 | @ ATL | 105 | W 6-3 | 48-57 | 5 | 6,378 | Jim Barr | Carl Morton | Elias Sosa | Danny Frisella | | 421 | 453 | -32 |
| 1974-07-31 | @ ATL | 106 | L 0-9 | 48-58 | 5 | 5,631 | John D'Acquisto | Phil Niekro | Phil Niekro | John D'Acquisto | | 421 | 462 | -41 |
| 1974-08-01 | vs CIN | 107 | L 7-9 | 48-59 | 5 | 3,818 | Charlie Williams | Tom Carroll | Clay Carroll | Ron Bryant | | 428 | 471 | -43 |
| 1974-08-02 | vs CIN | 108 | L 4-9 | 48-60 | 5 | 6,737 | Ed Halicki | Jack Billingham | Jack Billingham | Ed Halicki | | 432 | 480 | -48 |
| 1974-08-03 | vs ATL | 109 | W 3-1 | 49-60 | 5 | 13,061 | Jim Barr | Buzz Capra | Jim Barr | Buzz Capra | | 435 | 481 | -46 |
| 1974-08-04 | vs ATL | 110 | L 2-4 | 50-61 | 5 | 0 | John D'Acquisto | Ron Reed | Tom House | John D'Acquisto | | 437 | 485 | -48 |
| 1974-08-04 | vs ATL | 111 | W 5-2 | 50-61 | 5 | 11,003 | Mike Caldwell | Max Leon | Mike Caldwell | Max Leon | | 442 | 487 | -45 |
| 1974-08-05 | vs HOU | 112 | L 2-7 | 50-62 | 5 | 4,896 | Charlie Williams | Don Wilson | Don Wilson | Charlie Williams | | 444 | 494 | -50 |
| 1974-08-06 | vs HOU | 113 | L 4-13 | 50-63 | 5 | 2,746 | Ed Halicki | Tom Griffin | Mike Cosgrove | Ed Halicki | | 448 | 507 | -59 |
| 1974-08-09 | @ CHN | 114 | W 3-0 | 51-63 | 5 | 10,777 | Jim Barr | Steve Stone | Jim Barr | Steve Stone | | 451 | 507 | -56 |
| 1974-08-11 | @ CHN | 115 | W 5-3 | 53-63 | 5 | 0 | Mike Caldwell | Rick Reuschel | Mike Caldwell | Rick Reuschel | | 456 | 510 | -54 |
| 1974-08-11 | @ CHN | 116 | W 6-4 | 53-63 | 5 | 18,554 | John D'Acquisto | Ken Frailing | Elias Sosa | Oscar Zamora | | 462 | 514 | -52 |
| 1974-08-12 | @ PHI | 117 | L 1-4 | 53-64 | 5 | 16,271 | Ed Halicki | Jim Lonborg | Jim Lonborg | Ed Halicki | | 463 | 518 | -55 |
| 1974-08-13 | @ PHI | 118 | L 5-6 | 53-65 | 5 | 27,618 | Jim Barr | Dick Ruthven | Dick Ruthven | Jim Barr | Ron Schueler | 468 | 524 | -56 |
| 1974-08-14 | @ PHI | 119 | W 6-4 | 54-65 | 5 | 24,061 | Charlie Williams | Wayne Twitchell | Elias Sosa | Mac Scarce | | 474 | 528 | -54 |
| 1974-08-16 | @ SLN | 120 | L 1-2 | 54-66 | 5 | 28,723 | John D'Acquisto | Bob Gibson | Bob Gibson | John D'Acquisto | | 475 | 530 | -55 |
| 1974-08-17 | @ SLN | 121 | L 3-5 | 54-67 | 5 | 32,128 | Mike Caldwell | Lynn McGlothen | Mike Garman | Randy Moffitt | | 478 | 535 | -57 |
| 1974-08-18 | @ SLN | 122 | L 1-4 | 54-68 | 5 | 30,208 | Tom Bradley | John Curtis | John Curtis | Tom Bradley | | 479 | 539 | -60 |
| 1974-08-19 | @ PIT | 123 | W 5-3 | 55-68 | 5 | 14,077 | Ron Bryant | Jim Rooker | Ron Bryant | Jim Rooker | Elias Sosa | 484 | 542 | -58 |
| 1974-08-20 | @ PIT | 124 | W 8-7 | 56-68 | 5 | 15,944 | John D'Acquisto | Bruce Kison | Mike Caldwell | John Morlan | | 492 | 549 | -57 |
| 1974-08-21 | @ PIT | 125 | L 2-4 | 56-69 | 5 | 19,814 | Ed Halicki | Dock Ellis | Dock Ellis | Ed Halicki | | 494 | 553 | -59 |
| 1974-08-23 | vs CHN | 126 | L 0-1 | 57-69 | 5 | 3,099 | Jim Barr | Rick Reuschel | Rick Reuschel | Jim Barr | | 494 | 554 | -60 |
| 1974-08-24 | vs CHN | 127 | L 1-2 | 57-70 | 5 | 7,155 | Ron Bryant | Steve Stone | Steve Stone | Ron Bryant | Burt Hooton | 495 | 556 | -61 |
| 1974-08-25 | vs CHN | 128 | W 4-3 | 58-70 | 5 | 5,257 | Mike Caldwell | Bill Bonham | Elias Sosa | Oscar Zamora | | 499 | 559 | -60 |
| 1974-08-27 | vs PIT | 129 | L 2-13 | 58-71 | 5 | 3,273 | John D'Acquisto | Dock Ellis | Dock Ellis | John D'Acquisto | | 501 | 572 | -71 |
| 1974-08-28 | vs PIT | 130 | L 1-3 | 58-72 | 5 | 3,679 | Jim Barr | Jerry Reuss | Dave Giusti | Jim Barr | | 502 | 575 | -73 |
| 1974-08-29 | vs PIT | 131 | W 3-2 | 59-72 | 5 | 3,172 | Ron Bryant | Bruce Kison | Randy Moffitt | Dave Giusti | | 505 | 577 | -72 |
| 1974-08-30 | vs SLN | 132 | W 8-2 | 60-72 | 5 | 3,111 | Mike Caldwell | Sonny Siebert | Mike Caldwell | Sonny Siebert | | 513 | 579 | -66 |
| 1974-08-31 | vs SLN | 133 | W 3-2 | 61-72 | 5 | 14,356 | John D'Acquisto | Bob Forsch | John D'Acquisto | Bob Forsch | John Morris | 516 | 581 | -65 |
| 1974-09-01 | vs SLN | 134 | L 1-8 | 61-73 | 5 | 6,842 | Ed Halicki | Bob Gibson | Bob Gibson | Ed Halicki | | 517 | 589 | -72 |
| 1974-09-02 | @ LAN | 135 | W 5-3 | 62-73 | 5 | 30,713 | Jim Barr | Andy Messersmith | Jim Barr | Andy Messersmith | | 522 | 592 | -70 |
| 1974-09-03 | @ LAN | 136 | W 9-5 | 63-73 | 5 | 25,187 | Ron Bryant | Doug Rau | John Montefusco | Doug Rau | | 531 | 597 | -66 |
| 1974-09-04 | @ LAN | 137 | L 3-6 | 63-74 | 5 | 28,453 | Mike Caldwell | Geoff Zahn | Charlie Hough | Randy Moffitt | | 534 | 603 | -69 |
| 1974-09-06 | @ ATL | 138 | W 2-0 | 64-74 | 5 | 2,122 | John D'Acquisto | Carl Morton | John D'Acquisto | Carl Morton | | 536 | 603 | -67 |
| 1974-09-07 | @ ATL | 139 | W 6-0 | 65-74 | 5 | 6,051 | Jim Barr | Phil Niekro | Jim Barr | Phil Niekro | | 542 | 603 | -61 |
| 1974-09-08 | @ ATL | 140 | L 3-5 | 65-75 | 5 | 5,210 | Ron Bryant | Ron Reed | Ron Reed | Ron Bryant | | 545 | 608 | -63 |
| 1974-09-09 | @ HOU | 141 | W 8-6 | 66-75 | 5 | 3,741 | John Montefusco | Larry Dierker | John Montefusco | Larry Dierker | Elias Sosa | 553 | 614 | -61 |
| 1974-09-10 | @ HOU | 142 | W 6-5 | 67-75 | 5 | 4,431 | Mike Caldwell | Dave Roberts | John Morris | Ken Forsch | Randy Moffitt | 559 | 619 | -60 |
| 1974-09-11 | vs LAN | 143 | L 4-5 | 67-76 | 5 | 7,842 | John D'Acquisto | Andy Messersmith | Andy Messersmith | Gary Lavelle | | 563 | 624 | -61 |
| 1974-09-12 | vs LAN | 144 | L 0-11 | 67-77 | 5 | 7,349 | Jim Barr | Al Downing | Al Downing | Jim Barr | | 563 | 635 | -72 |
| 1974-09-13 | vs HOU | 145 | L 4-5 | 67-78 | 5 | 1,732 | Ron Bryant | J.R. Richard | Mike Cosgrove | Ron Bryant | Ken Forsch | 567 | 640 | -73 |
| 1974-09-14 | vs HOU | 146 | L 0-5 | 67-79 | 5 | 3,144 | John Montefusco | Larry Dierker | Larry Dierker | John Montefusco | | 567 | 645 | -78 |
| 1974-09-15 | vs HOU | 147 | L 0-6 | 68-80 | 5 | 0 | Mike Caldwell | Paul Siebert | Paul Siebert | Mike Caldwell | | 567 | 651 | -84 |
| 1974-09-15 | vs HOU | 148 | W 8-4 | 68-80 | 5 | 4,736 | John D'Acquisto | Dave Roberts | John D'Acquisto | Dave Roberts | | 575 | 655 | -80 |
| 1974-09-16 | vs ATL | 149 | W 4-2 | 69-80 | 5 | 748 | Jim Barr | Ron Reed | Jim Barr | Ron Reed | | 579 | 657 | -78 |
| 1974-09-17 | vs ATL | 150 | L 3-4 | 69-81 | 5 | 1,347 | Ron Bryant | Buzz Capra | Buzz Capra | John Morris | | 582 | 661 | -79 |
| 1974-09-18 | vs ATL | 151 | L 2-4 | 69-82 | 5 | 1,503 | John Montefusco | Carl Morton | Carl Morton | John Montefusco | Tom House | 584 | 665 | -81 |
| 1974-09-19 | vs CIN | 152 | L 4-8 | 69-83 | 5 | 2,074 | John D'Acquisto | Fred Norman | Fred Norman | John D'Acquisto | | 588 | 673 | -85 |
| 1974-09-20 | vs CIN | 153 | W 4-3 | 70-83 | 5 | 3,924 | Mike Caldwell | Clay Kirby | Mike Caldwell | Clay Kirby | | 592 | 676 | -84 |
| 1974-09-21 | vs CIN | 154 | W 8-6 | 71-83 | 5 | 5,455 | Jim Barr | Jack Billingham | Butch Metzger | Pedro Borbon | | 600 | 682 | -82 |
| 1974-09-22 | vs CIN | 155 | W 6-0 | 72-83 | 5 | 16,801 | John Montefusco | Don Gullett | John Montefusco | Don Gullett | | 606 | 682 | -76 |
| 1974-09-24 | @ SDN | 156 | L 2-3 | 72-84 | 5 | 2,654 | John D'Acquisto | Rusty Gerhardt | Rusty Gerhardt | Elias Sosa | Randy Jones | 608 | 685 | -77 |
| 1974-09-25 | @ SDN | 157 | L 2-3 | 72-85 | 5 | 5,070 | Mike Caldwell | Joe McIntosh | Larry Hardy | Mike Caldwell | Bill Greif | 610 | 688 | -78 |
| 1974-09-27 | @ CIN | 158 | L 3-4 | 72-86 | 5 | 18,967 | Jim Barr | Pat Darcy | Tom Hall | Gary Lavelle | | 613 | 692 | -79 |
| 1974-09-28 | @ CIN | 159 | L 6-13 | 72-87 | 5 | 28,158 | John Montefusco | Fred Norman | Clay Carroll | Gary Lavelle | | 619 | 705 | -86 |
| 1974-09-29 | @ CIN | 160 | L 3-7 | 72-88 | 5 | 50,342 | John D'Acquisto | Clay Kirby | Clay Kirby | John D'Acquisto | | 622 | 712 | -90 |
| 1974-10-01 | vs SDN | 161 | W 7-2 | 73-88 | 5 | 1,192 | Tom Bradley | Dave Freisleben | Tom Bradley | Dave Freisleben | Jim Barr | 629 | 714 | -85 |
| 1974-10-02 | vs SDN | 162 | L 5-9 | 73-89 | 5 | 1,349 | Ed Halicki | Dan Spillner | Larry Hardy | Elias Sosa | | 634 | 723 | -89 |