| 1974-04-05 | @ SLN | 1 | L 5-6 | 0-1 | 6 | 24,210 | Jerry Reuss | Bob Gibson | Al Hrabosky | Dave Giusti | | 5 | 6 | -1 |
| 1974-04-06 | @ SLN | 2 | L 0-8 | 0-2 | 6 | 17,875 | Bob Moose | Sonny Siebert | Sonny Siebert | Bob Moose | | 5 | 14 | -9 |
| 1974-04-10 | vs MON | 3 | L 8-12 | 0-3 | 6 | 40,434 | Ken Brett | Steve Renko | Chuck Taylor | Ramon Hernandez | | 13 | 26 | -13 |
| 1974-04-11 | vs MON | 4 | L 1-5 | 0-4 | 6 | 5,606 | Dock Ellis | Steve Rogers | Steve Rogers | Dock Ellis | | 14 | 31 | -17 |
| 1974-04-12 | vs SLN | 5 | L 6-7 | 0-5 | 6 | 9,524 | Jerry Reuss | Sonny Siebert | Mike Garman | Bruce Kison | Rich Folkers | 20 | 38 | -18 |
| 1974-04-13 | vs SLN | 6 | L 4-6 | 0-6 | 6 | 7,026 | Jim Rooker | Lynn McGlothen | Lynn McGlothen | Jim Rooker | Pete Richert | 24 | 44 | -20 |
| 1974-04-14 | vs SLN | 7 | W 8-4 | 1-7 | 6 | 0 | Bob Moose | Mike Thompson | Bob Moose | Mike Thompson | | 32 | 48 | -16 |
| 1974-04-14 | vs SLN | 8 | L 5-6 | 1-7 | 6 | 11,949 | Ken Brett | John Curtis | John Curtis | Ken Brett | Rich Folkers | 37 | 54 | -17 |
| 1974-04-16 | @ CHN | 9 | W 8-5 | 2-7 | 6 | 14,953 | Dock Ellis | Rick Reuschel | Bruce Kison | Mike Paul | | 45 | 59 | -14 |
| 1974-04-17 | @ CHN | 10 | L 9-18 | 2-8 | 6 | 15,560 | Jerry Reuss | Burt Hooton | Burt Hooton | Jerry Reuss | | 54 | 77 | -23 |
| 1974-04-18 | @ CHN | 11 | L 0-1 | 2-9 | 6 | 13,054 | Jim Rooker | Ken Frailing | Ken Frailing | Jim Rooker | Ray Burris | 54 | 78 | -24 |
| 1974-04-20 | @ NYN | 12 | L 2-5 | 2-10 | 6 | 18,070 | Bob Moose | Jerry Koosman | Jerry Koosman | Bob Moose | | 56 | 83 | -27 |
| 1974-04-21 | @ NYN | 13 | W 7-0 | 3-10 | 6 | 23,375 | Ken Brett | Tom Seaver | Ken Brett | Tom Seaver | | 63 | 83 | -20 |
| 1974-04-24 | @ ATL | 14 | W 5-3 | 4-10 | 5 | 3,395 | Dock Ellis | Phil Niekro | Dock Ellis | Phil Niekro | Dave Giusti | 68 | 86 | -18 |
| 1974-04-25 | @ ATL | 15 | L 2-3 | 4-11 | 6 | 3,437 | Jerry Reuss | Ron Reed | Ron Reed | Jerry Reuss | | 70 | 89 | -19 |
| 1974-04-26 | vs HOU | 16 | W 4-3 | 5-11 | 6 | 11,145 | Jim Rooker | Larry Dierker | Dave Giusti | Fred Scherman | | 74 | 92 | -18 |
| 1974-04-27 | vs HOU | 17 | L 7-10 | 5-12 | 6 | 6,835 | Bob Moose | Tom Griffin | Tom Griffin | Bob Moose | | 81 | 102 | -21 |
| 1974-04-28 | vs HOU | 18 | W 7-3 | 6-12 | 6 | 13,073 | Ken Brett | Claude Osteen | Ken Brett | Claude Osteen | Dave Giusti | 88 | 105 | -17 |
| 1974-05-01 | vs CIN | 19 | L 3-5 | 6-13 | 6 | 8,195 | Dock Ellis | Don Gullett | Clay Carroll | John Morlan | Pedro Borbon | 91 | 110 | -19 |
| 1974-05-03 | vs ATL | 20 | W 4-2 | 7-13 | 6 | 11,248 | Jerry Reuss | Roric Harrison | Jerry Reuss | Roric Harrison | | 95 | 112 | -17 |
| 1974-05-04 | vs ATL | 21 | W 4-3 | 8-13 | 6 | 8,069 | Jim Rooker | Phil Niekro | Jim Rooker | Phil Niekro | | 99 | 115 | -16 |
| 1974-05-05 | vs ATL | 22 | L 2-3 | 8-14 | 6 | 13,596 | Ken Brett | Ron Reed | Ron Reed | Ken Brett | Tom House | 101 | 118 | -17 |
| 1974-05-07 | @ HOU | 23 | L 1-2 | 8-15 | 6 | 9,909 | Dock Ellis | Tom Griffin | Tom Griffin | Dock Ellis | | 102 | 120 | -18 |
| 1974-05-08 | @ HOU | 24 | L 6-8 | 8-16 | 6 | 11,266 | Jerry Reuss | Claude Osteen | Mike Nagy | Jim Sadowski | | 108 | 128 | -20 |
| 1974-05-09 | @ HOU | 25 | W 4-1 | 9-16 | 6 | 10,864 | Jim Rooker | Dave Roberts | Jim Rooker | Dave Roberts | | 112 | 129 | -17 |
| 1974-05-10 | @ PHI | 26 | L 2-3 | 9-17 | 6 | 16,388 | Ken Brett | Dick Ruthven | Dick Ruthven | Ken Brett | Mac Scarce | 114 | 132 | -18 |
| 1974-05-11 | @ PHI | 27 | L 1-3 | 9-18 | 6 | 21,070 | Bob Moose | Steve Carlton | Steve Carlton | Bob Moose | | 115 | 135 | -20 |
| 1974-05-12 | @ PHI | 28 | L 7-8 | 9-19 | 6 | 11,243 | Dock Ellis | Ron Schueler | Ed Farmer | Dock Ellis | Eddie Watt | 122 | 143 | -21 |
| 1974-05-14 | vs CHN | 29 | L 1-7 | 9-20 | 6 | 6,541 | Jerry Reuss | Rick Reuschel | Rick Reuschel | Jerry Reuss | | 123 | 150 | -27 |
| 1974-05-15 | vs CHN | 30 | W 3-2 | 10-20 | 6 | 6,873 | Jim Rooker | Burt Hooton | Bruce Kison | Bill Bonham | | 126 | 152 | -26 |
| 1974-05-16 | vs CHN | 31 | W 5-2 | 11-20 | 6 | 5,845 | Ken Brett | Ken Frailing | Ken Brett | Ken Frailing | Bruce Kison | 131 | 154 | -23 |
| 1974-05-18 | vs PHI | 32 | L 2-9 | 11-21 | 6 | 8,021 | Bob Moose | Ron Schueler | Ron Schueler | Bob Moose | | 133 | 163 | -30 |
| 1974-05-19 | vs PHI | 33 | L 2-3 | 12-22 | 6 | 0 | Dock Ellis | Jim Lonborg | Jim Lonborg | Dock Ellis | Eddie Watt | 135 | 166 | -31 |
| 1974-05-19 | vs PHI | 34 | W 2-1 | 12-22 | 6 | 13,426 | Jerry Reuss | Dick Ruthven | Jerry Reuss | Dick Ruthven | | 137 | 167 | -30 |
| 1974-05-20 | @ MON | 35 | L 2-4 | 12-23 | 6 | 12,228 | Jim Rooker | Mike Torrez | Mike Torrez | Jim Rooker | Chuck Taylor | 139 | 171 | -32 |
| 1974-05-21 | @ MON | 36 | W 8-4 | 13-23 | 6 | 9,231 | Ken Brett | Balor Moore | Ken Brett | Balor Moore | | 147 | 175 | -28 |
| 1974-05-23 | @ MON | 37 | L 4-5 | 13-24 | 6 | 7,209 | Bruce Kison | Steve Rogers | Steve Rogers | Bruce Kison | Chuck Taylor | 151 | 180 | -29 |
| 1974-05-24 | vs NYN | 38 | W 4-1 | 14-24 | 6 | 12,257 | Jerry Reuss | Jon Matlack | Jerry Reuss | Jon Matlack | | 155 | 181 | -26 |
| 1974-05-25 | vs NYN | 39 | L 3-4 | 14-25 | 6 | 11,260 | Dock Ellis | Jerry Koosman | Jerry Koosman | Dock Ellis | | 158 | 185 | -27 |
| 1974-05-26 | vs NYN | 40 | L 3-5 | 14-26 | 6 | 15,573 | Jim Rooker | Craig Swan | Ray Sadecki | Dave Giusti | Harry Parker | 161 | 190 | -29 |
| 1974-05-27 | vs SDN | 41 | W 6-0 | 16-26 | 6 | 0 | Ken Brett | Randy Jones | Ken Brett | Randy Jones | | 167 | 190 | -23 |
| 1974-05-27 | vs SDN | 42 | W 8-7 | 16-26 | 6 | 15,367 | Bruce Kison | Dan Spillner | Kent Tekulve | Jim McAndrew | | 175 | 197 | -22 |
| 1974-05-29 | vs SDN | 43 | W 13-3 | 17-26 | 6 | 4,534 | Jerry Reuss | Larry Hardy | Jerry Reuss | Larry Hardy | | 188 | 200 | -12 |
| 1974-05-31 | @ CIN | 44 | L 5-7 | 17-27 | 6 | 40,205 | Jim Rooker | Jack Billingham | Pedro Borbon | Jim Rooker | | 193 | 207 | -14 |
| 1974-06-01 | @ CIN | 45 | W 14-1 | 18-27 | 6 | 36,999 | Ken Brett | Roger Nelson | Ken Brett | Roger Nelson | | 207 | 208 | -1 |
| 1974-06-02 | @ CIN | 46 | L 1-5 | 18-28 | 6 | 38,354 | Bruce Kison | Fred Norman | Fred Norman | Bruce Kison | | 208 | 213 | -5 |
| 1974-06-04 | @ LAN | 47 | L 0-5 | 18-29 | 6 | 23,472 | Jerry Reuss | Tommy John | Tommy John | Jerry Reuss | | 208 | 218 | -10 |
| 1974-06-05 | @ LAN | 48 | L 2-3 | 18-30 | 6 | 25,959 | Jim Rooker | Doug Rau | Mike Marshall | Jim Rooker | | 210 | 221 | -11 |
| 1974-06-06 | @ LAN | 49 | L 0-6 | 18-31 | 6 | 26,717 | Ken Brett | Andy Messersmith | Andy Messersmith | Ken Brett | | 210 | 227 | -17 |
| 1974-06-07 | @ SFN | 50 | L 2-6 | 18-32 | 6 | 3,845 | Larry Demery | John D'Acquisto | John D'Acquisto | Larry Demery | | 212 | 233 | -21 |
| 1974-06-08 | @ SFN | 51 | W 5-2 | 19-32 | 6 | 9,138 | Dock Ellis | Tom Bradley | Dock Ellis | Tom Bradley | Bruce Kison | 217 | 235 | -18 |
| 1974-06-09 | @ SFN | 52 | W 14-1 | 20-32 | 6 | 8,786 | Jerry Reuss | Ron Bryant | Jerry Reuss | Ron Bryant | | 231 | 236 | -5 |
| 1974-06-10 | @ SDN | 53 | L 8-9 | 20-33 | 6 | 7,309 | Jim Rooker | Lowell Palmer | Vicente Romo | Kent Tekulve | | 239 | 245 | -6 |
| 1974-06-11 | @ SDN | 54 | W 5-2 | 21-33 | 6 | 9,505 | Ken Brett | Randy Jones | Ken Brett | Randy Jones | | 244 | 247 | -3 |
| 1974-06-12 | @ SDN | 55 | L 2-5 | 21-34 | 6 | 12,336 | Larry Demery | Dave Freisleben | Dave Freisleben | Larry Demery | Dave Tomlin | 246 | 252 | -6 |
| 1974-06-14 | vs SFN | 56 | W 4-2 | 22-34 | 6 | 18,588 | Dock Ellis | Ron Bryant | Dock Ellis | Ron Bryant | | 250 | 254 | -4 |
| 1974-06-15 | vs SFN | 57 | W 3-2 | 23-34 | 6 | 13,571 | Jerry Reuss | John D'Acquisto | Daryl Patterson | Elias Sosa | | 253 | 256 | -3 |
| 1974-06-16 | vs SFN | 58 | W 4-3 | 24-34 | 5 | 12,606 | Jim Rooker | Tom Bradley | Jim Rooker | Tom Bradley | | 257 | 259 | -2 |
| 1974-06-17 | vs LAN | 59 | W 7-3 | 25-34 | 5 | 17,105 | Ken Brett | Don Sutton | Ken Brett | Don Sutton | | 264 | 262 | 2 |
| 1974-06-18 | vs LAN | 60 | W 2-0 | 26-34 | 4 | 15,054 | Dave Giusti | Tommy John | Dave Giusti | Tommy John | Daryl Patterson | 266 | 262 | 4 |
| 1974-06-19 | vs LAN | 61 | W 7-3 | 27-34 | 4 | 16,493 | Jerry Reuss | Doug Rau | Jerry Reuss | Doug Rau | | 273 | 265 | 8 |
| 1974-06-20 | @ CHN | 62 | L 0-3 | 27-35 | 4 | 12,321 | Dock Ellis | Rick Reuschel | Rick Reuschel | Dock Ellis | | 273 | 268 | 5 |
| 1974-06-21 | @ CHN | 63 | L 2-3 | 27-36 | 5 | 11,625 | Jim Rooker | Steve Stone | Steve Stone | Jim Rooker | Oscar Zamora | 275 | 271 | 4 |
| 1974-06-22 | @ CHN | 64 | W 6-0 | 28-36 | 4 | 10,069 | Ken Brett | Ken Frailing | Ken Brett | Ken Frailing | | 281 | 271 | 10 |
| 1974-06-23 | @ CHN | 65 | L 3-7 | 28-37 | 5 | 24,855 | Bruce Kison | Bill Bonham | Bill Bonham | Dave Giusti | | 284 | 278 | 6 |
| 1974-06-24 | @ SLN | 66 | L 1-3 | 28-39 | 5 | 0 | Jerry Reuss | Alan Foster | Alan Foster | Jerry Reuss | Mike Garman | 285 | 281 | 4 |
| 1974-06-24 | @ SLN | 67 | L 0-4 | 28-39 | 5 | 25,093 | Larry Demery | Bob Gibson | Bob Gibson | Larry Demery | | 285 | 285 | 0 |
| 1974-06-25 | @ SLN | 68 | L 7-8 | 28-40 | 5 | 17,392 | Dock Ellis | Mike Thompson | Al Hrabosky | Daryl Patterson | John Curtis | 292 | 293 | -1 |
| 1974-06-26 | @ SLN | 69 | W 7-2 | 29-40 | 4 | 18,487 | Jim Rooker | Sonny Siebert | Jim Rooker | Sonny Siebert | | 299 | 295 | 4 |
| 1974-06-29 | vs PHI | 70 | W 6-3 | 30-40 | 5 | 15,839 | Jerry Reuss | Jim Lonborg | Jerry Reuss | Jim Lonborg | | 305 | 298 | 7 |
| 1974-06-30 | vs PHI | 71 | W 11-8 | 32-40 | 4 | 0 | Ken Brett | Steve Carlton | Ken Brett | Steve Carlton | | 316 | 306 | 10 |
| 1974-06-30 | vs PHI | 72 | W 3-2 | 32-40 | 4 | 25,730 | Dock Ellis | Ron Schueler | Bruce Kison | Ron Schueler | | 319 | 308 | 11 |
| 1974-07-02 | vs MON | 73 | W 4-2 | 33-40 | 4 | 13,138 | Jim Rooker | Mike Torrez | Jim Rooker | John Montague | | 323 | 310 | 13 |
| 1974-07-03 | vs MON | 74 | W 2-1 | 34-40 | 4 | 11,123 | Jerry Reuss | Don DeMola | Jerry Reuss | John Montague | | 325 | 311 | 14 |
| 1974-07-04 | vs MON | 75 | L 1-2 | 35-41 | 4 | 0 | Ken Brett | Steve Rogers | Steve Rogers | Ken Brett | | 326 | 313 | 13 |
| 1974-07-04 | vs MON | 76 | W 3-2 | 35-41 | 4 | 22,456 | Dave Giusti | Dennis Blair | Bruce Kison | Dennis Blair | | 329 | 315 | 14 |
| 1974-07-05 | @ HOU | 77 | L 1-7 | 35-42 | 4 | 23,047 | Dock Ellis | Larry Dierker | Larry Dierker | Dock Ellis | | 330 | 322 | 8 |
| 1974-07-06 | @ HOU | 78 | L 0-1 | 35-43 | 4 | 29,640 | Larry Demery | Don Wilson | Don Wilson | Bruce Kison | | 330 | 323 | 7 |
| 1974-07-07 | @ HOU | 79 | W 6-4 | 36-43 | 4 | 18,984 | Jim Rooker | Claude Osteen | Dave Giusti | Fred Scherman | | 336 | 327 | 9 |
| 1974-07-08 | vs ATL | 80 | L 0-5 | 36-44 | 5 | 11,494 | Jerry Reuss | Max Leon | Max Leon | Jerry Reuss | | 336 | 332 | 4 |
| 1974-07-09 | vs ATL | 81 | W 5-4 | 37-44 | 4 | 13,737 | Ken Brett | Phil Niekro | Ken Brett | Phil Niekro | Dave Giusti | 341 | 336 | 5 |
| 1974-07-10 | vs ATL | 82 | L 5-10 | 37-45 | 5 | 13,922 | Dock Ellis | Carl Morton | Carl Morton | Dock Ellis | | 346 | 346 | 0 |
| 1974-07-12 | vs CIN | 83 | L 0-7 | 37-47 | 5 | 0 | Jim Rooker | Don Gullett | Don Gullett | Jim Rooker | | 346 | 353 | -7 |
| 1974-07-12 | vs CIN | 84 | L 3-4 | 37-47 | 5 | 30,507 | Larry Demery | Tom Carroll | Tom Carroll | Larry Demery | Clay Carroll | 349 | 357 | -8 |
| 1974-07-13 | vs CIN | 85 | L 4-9 | 37-48 | 5 | 15,386 | Jerry Reuss | Tom Hall | Tom Hall | Jerry Reuss | Pedro Borbon | 353 | 366 | -13 |
| 1974-07-14 | vs CIN | 86 | L 2-3 | 38-49 | 5 | 0 | Ken Brett | Fred Norman | Fred Norman | Ken Brett | Clay Carroll | 355 | 369 | -14 |
| 1974-07-14 | vs CIN | 87 | W 2-1 | 38-49 | 5 | 27,151 | Bruce Kison | Jack Billingham | Bruce Kison | Jack Billingham | Dave Giusti | 357 | 370 | -13 |
| 1974-07-15 | vs HOU | 88 | W 3-1 | 39-49 | 4 | 9,171 | Dock Ellis | Dave Roberts | Dock Ellis | Dave Roberts | | 360 | 371 | -11 |
| 1974-07-16 | vs HOU | 89 | W 6-2 | 40-49 | 4 | 9,935 | Jim Rooker | Larry Dierker | Jim Rooker | Larry Dierker | | 366 | 373 | -7 |
| 1974-07-17 | vs HOU | 90 | W 11-3 | 41-49 | 4 | 10,941 | Larry Demery | Don Wilson | Larry Demery | Don Wilson | | 377 | 376 | 1 |
| 1974-07-18 | @ ATL | 91 | W 4-0 | 42-49 | 4 | 8,262 | Jerry Reuss | Ron Reed | Jerry Reuss | Ron Reed | | 381 | 376 | 5 |
| 1974-07-19 | @ ATL | 92 | W 2-0 | 43-49 | 4 | 9,583 | Ken Brett | Phil Niekro | Ken Brett | Phil Niekro | Dave Giusti | 383 | 376 | 7 |
| 1974-07-20 | @ ATL | 93 | W 7-6 | 44-49 | 4 | 40,225 | Bruce Kison | Carl Morton | Dave Giusti | Danny Frisella | | 390 | 382 | 8 |
| 1974-07-21 | @ ATL | 94 | W 6-2 | 45-49 | 4 | 9,351 | Dock Ellis | Buzz Capra | Dock Ellis | Buzz Capra | | 396 | 384 | 12 |
| 1974-07-25 | @ MON | 95 | L 5-10 | 46-50 | 4 | 0 | Jim Rooker | Steve Renko | Steve Renko | Jim Rooker | | 401 | 394 | 7 |
| 1974-07-25 | @ MON | 96 | W 3-2 | 46-50 | 4 | 27,283 | Jerry Reuss | Steve Rogers | Jerry Reuss | Steve Rogers | Dave Giusti | 404 | 396 | 8 |
| 1974-07-26 | @ MON | 97 | W 3-0 | 47-50 | 3 | 22,278 | Dock Ellis | Dennis Blair | Dock Ellis | Dennis Blair | Ramon Hernandez | 407 | 396 | 11 |
| 1974-07-27 | @ PHI | 98 | L 5-6 | 47-52 | 3 | 0 | Ken Brett | Dick Ruthven | Pete Richert | Ken Brett | | 412 | 402 | 10 |
| 1974-07-27 | @ PHI | 99 | L 4-7 | 47-52 | 3 | 55,066 | Bruce Kison | Wayne Twitchell | Wayne Twitchell | Bruce Kison | Eddie Watt | 416 | 409 | 7 |
| 1974-07-28 | @ PHI | 100 | W 4-3 | 48-52 | 3 | 34,049 | Larry Demery | Ron Schueler | Dave Giusti | Mac Scarce | | 420 | 412 | 8 |
| 1974-07-29 | @ PHI | 101 | L 1-13 | 48-53 | 3 | 27,760 | Jerry Reuss | Steve Carlton | Steve Carlton | Jerry Reuss | | 421 | 425 | -4 |
| 1974-07-30 | @ NYN | 102 | W 6-0 | 49-54 | 3 | 0 | Jim Rooker | Jon Matlack | Jim Rooker | Jon Matlack | | 427 | 425 | 2 |
| 1974-07-30 | @ NYN | 103 | L 3-4 | 49-54 | 3 | 39,246 | Bruce Kison | Jerry Koosman | Jerry Koosman | Bruce Kison | | 430 | 429 | 1 |
| 1974-07-31 | @ NYN | 104 | W 8-3 | 50-54 | 3 | 23,281 | Dock Ellis | Tom Seaver | Dock Ellis | Tom Seaver | | 438 | 432 | 6 |
| 1974-08-01 | vs SLN | 105 | L 2-5 | 50-55 | 3 | 17,318 | Ken Brett | Lynn McGlothen | Rich Folkers | Dave Giusti | | 440 | 437 | 3 |
| 1974-08-02 | vs SLN | 106 | W 3-2 | 51-55 | 3 | 19,385 | Larry Demery | Bob Forsch | Ramon Hernandez | Orlando Pena | | 443 | 439 | 4 |
| 1974-08-03 | vs CHN | 107 | L 3-4 | 51-56 | 3 | 9,316 | Jerry Reuss | Rick Reuschel | Rick Reuschel | Jerry Reuss | Dave LaRoche | 446 | 443 | 3 |
| 1974-08-04 | vs CHN | 108 | L 3-4 | 52-57 | 3 | 0 | Jim Rooker | Bill Bonham | Bill Bonham | Jim Rooker | | 449 | 447 | 2 |
| 1974-08-04 | vs CHN | 109 | W 7-1 | 52-57 | 3 | 23,536 | Bruce Kison | Herb Hutson | Bruce Kison | Herb Hutson | | 456 | 448 | 8 |
| 1974-08-06 | vs NYN | 110 | W 9-8 | 53-57 | 3 | 12,441 | Ken Brett | Jerry Koosman | Daryl Patterson | Tug McGraw | | 465 | 456 | 9 |
| 1974-08-07 | vs NYN | 111 | W 10-1 | 54-57 | 3 | 13,360 | Larry Demery | Harry Parker | Larry Demery | Harry Parker | | 475 | 457 | 18 |
| 1974-08-08 | vs NYN | 112 | W 4-3 | 55-57 | 3 | 11,191 | Jerry Reuss | Jon Matlack | Jerry Reuss | Jon Matlack | | 479 | 460 | 19 |
| 1974-08-09 | vs SDN | 113 | W 7-3 | 56-57 | 3 | 11,507 | Jim Rooker | Randy Jones | Jim Rooker | Randy Jones | | 486 | 463 | 23 |
| 1974-08-10 | vs SDN | 114 | L 4-8 | 56-58 | 3 | 15,150 | Bruce Kison | Dave Freisleben | Dave Freisleben | John Morlan | | 490 | 471 | 19 |
| 1974-08-11 | vs SDN | 115 | W 8-1 | 57-58 | 3 | 14,726 | Dock Ellis | Dan Spillner | Dock Ellis | Dan Spillner | | 498 | 472 | 26 |
| 1974-08-12 | @ CIN | 116 | W 7-4 | 58-58 | 3 | 30,327 | Jerry Reuss | Clay Kirby | Jerry Reuss | Clay Kirby | Dave Giusti | 505 | 476 | 29 |
| 1974-08-13 | @ CIN | 117 | W 14-3 | 59-58 | 3 | 32,280 | Larry Demery | Jack Billingham | Larry Demery | Jack Billingham | | 519 | 479 | 40 |
| 1974-08-14 | @ CIN | 118 | L 2-3 | 59-59 | 3 | 30,018 | Jim Rooker | Don Gullett | Clay Carroll | Bruce Kison | | 521 | 482 | 39 |
| 1974-08-16 | vs LAN | 119 | W 5-2 | 60-59 | 3 | 32,347 | Dock Ellis | Don Sutton | Dock Ellis | Don Sutton | | 526 | 484 | 42 |
| 1974-08-17 | vs LAN | 120 | W 4-3 | 61-59 | 3 | 18,681 | Jerry Reuss | Andy Messersmith | Jerry Reuss | Andy Messersmith | Dave Giusti | 530 | 487 | 43 |
| 1974-08-18 | vs LAN | 121 | W 10-3 | 62-59 | 3 | 33,225 | Larry Demery | Geoff Zahn | Larry Demery | Geoff Zahn | | 540 | 490 | 50 |
| 1974-08-19 | vs SFN | 122 | L 3-5 | 62-60 | 3 | 14,077 | Jim Rooker | Ron Bryant | Ron Bryant | Jim Rooker | Elias Sosa | 543 | 495 | 48 |
| 1974-08-20 | vs SFN | 123 | L 7-8 | 62-61 | 3 | 15,944 | Bruce Kison | John D'Acquisto | Mike Caldwell | John Morlan | | 550 | 503 | 47 |
| 1974-08-21 | vs SFN | 124 | W 4-2 | 63-61 | 3 | 19,814 | Dock Ellis | Ed Halicki | Dock Ellis | Ed Halicki | | 554 | 505 | 49 |
| 1974-08-23 | @ SDN | 125 | W 6-2 | 64-61 | 2 | 13,443 | Jerry Reuss | Bill Greif | Jerry Reuss | Bill Greif | | 560 | 507 | 53 |
| 1974-08-25 | @ SDN | 126 | W 4-1 | 66-61 | 1 | 0 | Jim Rooker | Randy Jones | Jim Rooker | Lowell Palmer | | 564 | 508 | 56 |
| 1974-08-25 | @ SDN | 127 | W 10-2 | 66-61 | 1 | 11,567 | Larry Demery | Dave Freisleben | Larry Demery | Dave Freisleben | | 574 | 510 | 64 |
| 1974-08-27 | @ SFN | 128 | W 13-2 | 67-61 | 1 | 3,273 | Dock Ellis | John D'Acquisto | Dock Ellis | John D'Acquisto | | 587 | 512 | 75 |
| 1974-08-28 | @ SFN | 129 | W 3-1 | 68-61 | 1 | 3,679 | Jerry Reuss | Jim Barr | Dave Giusti | Jim Barr | | 590 | 513 | 77 |
| 1974-08-29 | @ SFN | 130 | L 2-3 | 68-62 | 1 | 3,172 | Bruce Kison | Ron Bryant | Randy Moffitt | Dave Giusti | | 592 | 516 | 76 |
| 1974-08-30 | @ LAN | 131 | W 4-3 | 69-62 | 1 | 38,887 | Jim Rooker | Doug Rau | Jim Rooker | Mike Marshall | Dave Giusti | 596 | 519 | 77 |
| 1974-08-31 | @ LAN | 132 | W 4-3 | 70-62 | 1 | 41,653 | Larry Demery | Geoff Zahn | Larry Demery | Geoff Zahn | Dave Giusti | 600 | 522 | 78 |
| 1974-09-01 | @ LAN | 133 | L 2-6 | 70-63 | 1 | 29,667 | Dock Ellis | Don Sutton | Don Sutton | Dock Ellis | | 602 | 528 | 74 |
| 1974-09-02 | vs PHI | 134 | W 7-4 | 72-63 | 1 | 0 | Jerry Reuss | Steve Carlton | Jerry Reuss | Steve Carlton | | 609 | 532 | 77 |
| 1974-09-02 | vs PHI | 135 | W 11-1 | 72-63 | 1 | 45,181 | Bruce Kison | Ron Schueler | Bruce Kison | Ron Schueler | | 620 | 533 | 87 |
| 1974-09-03 | vs PHI | 136 | W 8-2 | 73-63 | 1 | 8,168 | Jim Rooker | Wayne Twitchell | Jim Rooker | Wayne Twitchell | | 628 | 535 | 93 |
| 1974-09-06 | vs MON | 137 | W 2-1 | 74-63 | 1 | 15,386 | Dock Ellis | Steve Renko | Dock Ellis | Steve Renko | | 630 | 536 | 94 |
| 1974-09-07 | vs MON | 138 | W 6-5 | 75-63 | 1 | 17,576 | Jerry Reuss | Mike Torrez | Ramon Hernandez | Dale Murray | | 636 | 541 | 95 |
| 1974-09-08 | vs MON | 139 | W 8-2 | 76-63 | 1 | 18,870 | Jim Rooker | Steve Rogers | Jim Rooker | Steve Rogers | | 644 | 543 | 101 |
| 1974-09-09 | @ CHN | 140 | L 4-9 | 76-64 | 1 | 2,918 | Larry Demery | Steve Stone | Steve Stone | Larry Demery | Dave LaRoche | 648 | 552 | 96 |
| 1974-09-10 | @ CHN | 141 | W 12-4 | 77-64 | 1 | 4,843 | Ken Brett | Rick Reuschel | Ken Brett | Rick Reuschel | | 660 | 556 | 104 |
| 1974-09-11 | @ PHI | 142 | L 5-8 | 77-65 | 1 | 21,117 | Dock Ellis | Steve Carlton | Ron Schueler | Ramon Hernandez | | 665 | 564 | 101 |
| 1974-09-12 | @ PHI | 143 | L 4-6 | 77-66 | 1 | 22,135 | Jerry Reuss | Wayne Twitchell | Gene Garber | Bruce Kison | | 669 | 570 | 99 |
| 1974-09-13 | @ MON | 144 | L 2-3 | 77-67 | 1 | 9,283 | Jim Rooker | Steve Rogers | Steve Rogers | Jim Rooker | | 671 | 573 | 98 |
| 1974-09-14 | @ MON | 145 | L 2-17 | 77-68 | 2 | 15,566 | Larry Demery | Dennis Blair | Dennis Blair | Larry Demery | | 673 | 590 | 83 |
| 1974-09-15 | @ MON | 146 | L 4-5 | 77-69 | 2 | 15,438 | Ken Brett | Steve Renko | Steve Renko | Ken Brett | Dale Murray | 677 | 595 | 82 |
| 1974-09-17 | vs SLN | 147 | L 1-2 | 77-70 | 2 | 21,458 | Jerry Reuss | Bob Gibson | Al Hrabosky | Jerry Reuss | | 678 | 597 | 81 |
| 1974-09-18 | vs SLN | 148 | W 4-1 | 78-70 | 2 | 18,126 | Jim Rooker | Lynn McGlothen | Jim Rooker | Lynn McGlothen | | 682 | 598 | 84 |
| 1974-09-19 | vs SLN | 149 | W 8-6 | 79-70 | 2 | 19,844 | Bruce Kison | John Curtis | Ramon Hernandez | Rich Folkers | Dave Giusti | 690 | 604 | 86 |
| 1974-09-20 | vs NYN | 150 | W 4-3 | 80-70 | 2 | 11,683 | Ken Brett | Ray Sadecki | Ramon Hernandez | Tug McGraw | | 694 | 607 | 87 |
| 1974-09-21 | vs NYN | 151 | L 2-4 | 80-71 | 2 | 7,160 | Juan Pizarro | Jerry Koosman | Jerry Koosman | Juan Pizarro | | 696 | 611 | 85 |
| 1974-09-22 | vs NYN | 152 | L 0-4 | 80-72 | 2 | 27,915 | Jerry Reuss | Jon Matlack | Jon Matlack | Jerry Reuss | | 696 | 615 | 81 |
| 1974-09-23 | @ SLN | 153 | W 1-0 | 81-72 | 2 | 33,525 | Jim Rooker | Lynn McGlothen | Jim Rooker | Lynn McGlothen | Dave Giusti | 697 | 615 | 82 |
| 1974-09-24 | @ SLN | 154 | W 7-3 | 82-72 | 1 | 37,197 | Bruce Kison | John Curtis | Bruce Kison | John Curtis | | 704 | 618 | 86 |
| 1974-09-25 | @ SLN | 155 | L 12-13 | 82-73 | 2 | 41,345 | Ken Brett | Bob Forsch | Mike Garman | Jim Minshall | | 716 | 631 | 85 |
| 1974-09-26 | @ NYN | 156 | W 11-5 | 83-73 | 1 | 9,250 | Juan Pizarro | Jerry Koosman | Juan Pizarro | Jerry Koosman | | 727 | 636 | 91 |
| 1974-09-27 | @ NYN | 157 | W 2-1 | 84-73 | 1 | 17,440 | Jerry Reuss | Jon Matlack | Jerry Reuss | Jon Matlack | | 729 | 637 | 92 |
| 1974-09-28 | @ NYN | 158 | W 7-3 | 85-73 | 1 | 13,059 | Jim Rooker | Tug McGraw | Jim Rooker | Tug McGraw | Ramon Hernandez | 736 | 640 | 96 |
| 1974-09-29 | @ NYN | 159 | L 2-7 | 85-74 | 1 | 50,653 | Ken Brett | Bob Apodaca | Bob Apodaca | Ken Brett | | 738 | 647 | 91 |
| 1974-09-30 | vs CHN | 160 | W 2-1 | 86-74 | 1 | 10,482 | Bruce Kison | Bill Bonham | Bruce Kison | Bill Bonham | | 740 | 648 | 92 |
| 1974-10-01 | vs CHN | 161 | W 6-5 | 87-74 | 1 | 13,801 | Jerry Reuss | Tom Dettore | Dave Giusti | Dave LaRoche | | 746 | 653 | 93 |
| 1974-10-02 | vs CHN | 162 | W 5-4 | 88-74 | 1 | 22,725 | Jim Rooker | Rick Reuschel | Ramon Hernandez | Ken Frailing | | 751 | 657 | 94 |