| 1974-04-06 | vs CLE | 1 | W 6-1 | 1-0 | 1 | 20,744 | Mel Stottlemyre | Gaylord Perry | Mel Stottlemyre | Gaylord Perry | | 6 | 1 | 5 |
| 1974-04-07 | vs CLE | 2 | W 7-1 | 2-0 | 1 | 12,509 | Pat Dobson | Dick Tidrow | Pat Dobson | Dick Tidrow | | 13 | 2 | 11 |
| 1974-04-08 | vs CLE | 3 | W 5-3 | 3-0 | 1 | 8,151 | Doc Medich | Bob Johnson | Doc Medich | Tom Hilgendorf | Tom Buskey | 18 | 5 | 13 |
| 1974-04-09 | @ DET | 4 | W 3-0 | 4-0 | 1 | 44,047 | Steve Kline | Mickey Lolich | Steve Kline | Mickey Lolich | Sparky Lyle | 21 | 5 | 16 |
| 1974-04-11 | @ DET | 5 | L 1-4 | 4-1 | 1 | 6,640 | Mel Stottlemyre | Joe Coleman | Joe Coleman | Mel Stottlemyre | | 22 | 9 | 13 |
| 1974-04-12 | @ CLE | 6 | L 1-9 | 4-2 | 2 | 6,101 | Pat Dobson | Gaylord Perry | Gaylord Perry | Pat Dobson | | 23 | 18 | 5 |
| 1974-04-13 | @ CLE | 7 | L 5-8 | 4-3 | 4 | 5,826 | Doc Medich | Dick Tidrow | Dick Tidrow | Doc Medich | | 28 | 26 | 2 |
| 1974-04-14 | @ CLE | 8 | W 9-5 | 5-4 | 4 | 0 | Steve Kline | Bob Johnson | Steve Kline | Bob Johnson | | 37 | 31 | 6 |
| 1974-04-14 | @ CLE | 9 | L 6-9 | 5-4 | 4 | 8,730 | Fritz Peterson | Milt Wilcox | Milt Wilcox | Sam McDowell | | 43 | 40 | 3 |
| 1974-04-16 | vs BOS | 10 | W 2-1 | 6-4 | 2 | 10,480 | Mel Stottlemyre | Luis Tiant | Mel Stottlemyre | Luis Tiant | | 45 | 41 | 4 |
| 1974-04-17 | vs BOS | 11 | L 3-4 | 6-5 | 4 | 11,517 | Pat Dobson | Bill Lee | Bill Lee | Pat Dobson | | 48 | 45 | 3 |
| 1974-04-18 | vs BOS | 12 | W 6-1 | 7-5 | 2 | 10,272 | Doc Medich | Rick Wise | Doc Medich | Rick Wise | | 54 | 46 | 8 |
| 1974-04-19 | @ BAL | 13 | L 3-5 | 7-6 | 4 | 7,002 | Steve Kline | Ross Grimsley | Ross Grimsley | Steve Kline | Grant Jackson | 57 | 51 | 6 |
| 1974-04-20 | @ BAL | 14 | W 4-3 | 8-6 | 3 | 5,095 | Mel Stottlemyre | Dave McNally | Mel Stottlemyre | Grant Jackson | | 61 | 54 | 7 |
| 1974-04-21 | @ BAL | 15 | L 5-6 | 9-7 | 3 | 0 | Pat Dobson | Jim Palmer | Doyle Alexander | Tom Buskey | | 66 | 60 | 6 |
| 1974-04-21 | @ BAL | 16 | W 3-0 | 9-7 | 3 | 20,329 | Sam McDowell | Mike Cuellar | Sam McDowell | Mike Cuellar | Fred Beene | 69 | 60 | 9 |
| 1974-04-24 | vs KCA | 17 | W 4-3 | 10-7 | 2 | 5,593 | Doc Medich | Marty Pattin | Doc Medich | Marty Pattin | Sparky Lyle | 73 | 63 | 10 |
| 1974-04-25 | vs KCA | 18 | L 1-6 | 10-8 | 2 | 5,646 | Steve Kline | Paul Splittorff | Paul Splittorff | Steve Kline | | 74 | 69 | 5 |
| 1974-04-26 | vs TEX | 19 | W 4-3 | 11-8 | 2 | 10,787 | Mel Stottlemyre | Steve Hargan | Mel Stottlemyre | Steve Hargan | | 78 | 72 | 6 |
| 1974-04-27 | vs TEX | 20 | L 1-6 | 11-9 | 3 | 10,162 | Pat Dobson | David Clyde | David Clyde | Pat Dobson | | 79 | 78 | 1 |
| 1974-04-28 | vs TEX | 21 | W 11-2 | 12-10 | 3 | 0 | Doc Medich | Pete Broberg | Doc Medich | Pete Broberg | | 90 | 80 | 10 |
| 1974-04-28 | vs TEX | 22 | L 5-8 | 12-10 | 3 | 27,540 | Sam McDowell | Fergie Jenkins | Fergie Jenkins | Sam McDowell | | 95 | 88 | 7 |
| 1974-04-30 | vs OAK | 23 | W 4-3 | 13-10 | 2 | 10,199 | Mel Stottlemyre | Vida Blue | Mel Stottlemyre | Vida Blue | Sparky Lyle | 99 | 91 | 8 |
| 1974-05-01 | vs OAK | 24 | W 4-3 | 14-10 | 1 | 7,600 | Pat Dobson | Catfish Hunter | Pat Dobson | Catfish Hunter | Sparky Lyle | 103 | 94 | 9 |
| 1974-05-03 | @ KCA | 25 | W 5-4 | 15-10 | 1 | 13,246 | Doc Medich | Marty Pattin | Doc Medich | Steve Mingori | Sparky Lyle | 108 | 98 | 10 |
| 1974-05-04 | @ KCA | 26 | L 1-5 | 15-11 | 1 | 18,978 | Mel Stottlemyre | Paul Splittorff | Paul Splittorff | Mel Stottlemyre | | 109 | 103 | 6 |
| 1974-05-05 | @ KCA | 27 | L 2-8 | 15-12 | 1 | 14,410 | Pat Dobson | Steve Busby | Steve Busby | Pat Dobson | | 111 | 111 | 0 |
| 1974-05-06 | @ TEX | 28 | W 6-4 | 16-12 | 1 | 25,559 | Dick Tidrow | David Clyde | Dick Tidrow | Jackie Brown | | 117 | 115 | 2 |
| 1974-05-07 | @ TEX | 29 | W 4-3 | 17-12 | 1 | 10,191 | Doc Medich | Jim Merritt | Sparky Lyle | Steve Foucault | | 121 | 118 | 3 |
| 1974-05-08 | @ BOS | 30 | L 0-4 | 17-13 | 1 | 13,985 | Mel Stottlemyre | Bill Lee | Bill Lee | Mel Stottlemyre | | 121 | 122 | -1 |
| 1974-05-09 | @ BOS | 31 | L 0-2 | 17-14 | 1 | 12,193 | Pat Dobson | Luis Tiant | Luis Tiant | Pat Dobson | | 121 | 124 | -3 |
| 1974-05-10 | vs MIL | 32 | W 7-2 | 18-14 | 1 | 9,177 | Dick Tidrow | Jim Colborn | Dick Tidrow | Jim Colborn | | 128 | 126 | 2 |
| 1974-05-11 | vs MIL | 33 | L 2-3 | 18-15 | 1 | 9,013 | Doc Medich | Jim Slaton | Jim Slaton | Doc Medich | Tom Murphy | 130 | 129 | 1 |
| 1974-05-12 | vs MIL | 34 | L 3-7 | 18-17 | 2 | 0 | Mel Stottlemyre | Clyde Wright | Clyde Wright | Mel Stottlemyre | | 133 | 136 | -3 |
| 1974-05-12 | vs MIL | 35 | L 1-5 | 18-17 | 2 | 15,848 | Dick Woodson | Kevin Kobel | Kevin Kobel | Dick Woodson | | 134 | 141 | -7 |
| 1974-05-14 | vs DET | 36 | L 2-5 | 18-18 | 5 | 9,598 | Pat Dobson | Mickey Lolich | Mickey Lolich | Pat Dobson | | 136 | 146 | -10 |
| 1974-05-15 | vs DET | 37 | L 5-6 | 18-19 | 5 | 7,360 | Dick Tidrow | Joe Coleman | Joe Coleman | Cecil Upshaw | John Hiller | 141 | 152 | -11 |
| 1974-05-17 | @ MIL | 38 | W 3-2 | 19-19 | 5 | 10,554 | Doc Medich | Clyde Wright | Doc Medich | Clyde Wright | Sparky Lyle | 144 | 154 | -10 |
| 1974-05-18 | @ MIL | 39 | L 2-5 | 19-20 | 4 | 9,165 | Mel Stottlemyre | Kevin Kobel | Kevin Kobel | Mel Stottlemyre | | 146 | 159 | -13 |
| 1974-05-19 | @ MIL | 40 | W 6-2 | 20-21 | 5 | 0 | Pat Dobson | Jim Slaton | Pat Dobson | Jim Slaton | | 152 | 161 | -9 |
| 1974-05-19 | @ MIL | 41 | L 1-3 | 20-21 | 5 | 26,986 | Dick Woodson | Bill Champion | Bill Champion | Dick Woodson | Tom Murphy | 153 | 164 | -11 |
| 1974-05-21 | @ BOS | 42 | L 6-14 | 20-22 | 6 | 15,208 | Dick Tidrow | Bill Lee | Bill Lee | Dick Tidrow | | 159 | 178 | -19 |
| 1974-05-22 | @ BOS | 43 | L 3-6 | 20-23 | 6 | 16,466 | Doc Medich | Luis Tiant | Luis Tiant | Doc Medich | | 162 | 184 | -22 |
| 1974-05-24 | vs BAL | 44 | L 3-6 | 20-24 | 6 | 11,369 | Mel Stottlemyre | Dave McNally | Dave McNally | Mel Stottlemyre | Bob Reynolds | 165 | 190 | -25 |
| 1974-05-25 | vs BAL | 45 | L 1-5 | 20-25 | 6 | 10,704 | Pat Dobson | Mike Cuellar | Mike Cuellar | Pat Dobson | | 166 | 195 | -29 |
| 1974-05-26 | vs BAL | 46 | W 6-5 | 22-25 | 6 | 0 | Dick Tidrow | Ross Grimsley | Dick Tidrow | Ross Grimsley | Sparky Lyle | 172 | 200 | -28 |
| 1974-05-26 | vs BAL | 47 | W 7-5 | 22-25 | 6 | 23,882 | Dick Woodson | Doyle Alexander | Mike Wallace | Doyle Alexander | Cecil Upshaw | 179 | 205 | -26 |
| 1974-05-27 | vs CHA | 48 | L 3-5 | 22-26 | 6 | 17,174 | Doc Medich | Skip Pitlock | Skip Pitlock | Doc Medich | Terry Forster | 182 | 210 | -28 |
| 1974-05-28 | vs CHA | 49 | W 3-2 | 23-26 | 6 | 9,075 | Mel Stottlemyre | Stan Bahnsen | Sparky Lyle | Terry Forster | | 185 | 212 | -27 |
| 1974-05-31 | @ MIN | 50 | L 2-5 | 23-27 | 6 | 7,241 | Dick Tidrow | Joe Decker | Joe Decker | Dick Tidrow | Bill Campbell | 187 | 217 | -30 |
| 1974-06-01 | @ MIN | 51 | W 6-5 | 24-27 | 4 | 7,037 | Doc Medich | Bert Blyleven | Sparky Lyle | Bill Campbell | Cecil Upshaw | 193 | 222 | -29 |
| 1974-06-02 | @ MIN | 52 | W 11-1 | 25-27 | 4 | 20,073 | Mel Stottlemyre | Vic Albury | Mel Stottlemyre | Vic Albury | | 204 | 223 | -19 |
| 1974-06-04 | @ CHA | 53 | L 2-9 | 25-28 | 6 | 14,351 | Pat Dobson | Wilbur Wood | Wilbur Wood | Pat Dobson | | 206 | 232 | -26 |
| 1974-06-05 | @ CHA | 54 | L 6-7 | 25-29 | 6 | 7,566 | Dick Tidrow | Skip Pitlock | Terry Forster | Cecil Upshaw | | 212 | 239 | -27 |
| 1974-06-06 | @ CHA | 55 | W 5-1 | 26-29 | 5 | 11,686 | Doc Medich | Stan Bahnsen | Doc Medich | Stan Bahnsen | | 217 | 240 | -23 |
| 1974-06-07 | vs MIN | 56 | L 2-3 | 26-30 | 6 | 12,514 | Mel Stottlemyre | Bert Blyleven | Bert Blyleven | Mel Stottlemyre | | 219 | 243 | -24 |
| 1974-06-08 | vs MIN | 57 | W 3-1 | 27-30 | 6 | 9,228 | Pat Dobson | Vic Albury | Pat Dobson | Vic Albury | | 222 | 244 | -22 |
| 1974-06-09 | vs MIN | 58 | W 4-3 | 28-30 | 5 | 50,093 | Dick Tidrow | Joe Decker | Sparky Lyle | Bill Campbell | | 226 | 247 | -21 |
| 1974-06-10 | vs CAL | 59 | W 7-5 | 29-30 | 4 | 11,510 | Doc Medich | Rudy May | Sparky Lyle | Skip Lockwood | | 233 | 252 | -19 |
| 1974-06-11 | vs CAL | 60 | L 4-5 | 29-31 | 5 | 10,884 | Mel Stottlemyre | Dick Lange | Dick Lange | Dave Pagan | Barry Raziano | 237 | 257 | -20 |
| 1974-06-12 | vs CAL | 61 | W 6-4 | 30-31 | 5 | 7,473 | Pat Dobson | Frank Tanana | Pat Dobson | Frank Tanana | Cecil Upshaw | 243 | 261 | -18 |
| 1974-06-14 | @ OAK | 62 | W 5-1 | 31-31 | 6 | 8,435 | Dick Tidrow | Ken Holtzman | Dick Tidrow | Ken Holtzman | | 248 | 262 | -14 |
| 1974-06-15 | @ OAK | 63 | L 1-9 | 31-32 | 5 | 27,016 | Doc Medich | Vida Blue | Vida Blue | Doc Medich | | 249 | 271 | -22 |
| 1974-06-16 | @ OAK | 64 | W 5-3 | 32-32 | 6 | 12,530 | Pat Dobson | Catfish Hunter | Pat Dobson | Catfish Hunter | | 254 | 274 | -20 |
| 1974-06-17 | @ CAL | 65 | W 5-1 | 33-32 | 5 | 18,150 | Dave Pagan | Frank Tanana | Mike Wallace | Frank Tanana | | 259 | 275 | -16 |
| 1974-06-18 | @ CAL | 66 | L 0-3 | 33-33 | 5 | 10,830 | Dick Tidrow | Nolan Ryan | Nolan Ryan | Dick Tidrow | Skip Lockwood | 259 | 278 | -19 |
| 1974-06-19 | @ CAL | 67 | W 2-1 | 34-33 | 5 | 9,628 | Doc Medich | Andy Hassler | Doc Medich | Andy Hassler | | 261 | 279 | -18 |
| 1974-06-21 | vs DET | 68 | L 2-3 | 34-34 | 6 | 13,661 | Pat Dobson | Mickey Lolich | Mickey Lolich | Cecil Upshaw | | 263 | 282 | -19 |
| 1974-06-22 | vs DET | 69 | L 1-4 | 34-35 | 5 | 13,506 | Dick Tidrow | Woodie Fryman | John Hiller | Dick Tidrow | | 264 | 286 | -22 |
| 1974-06-23 | vs DET | 70 | W 4-1 | 35-35 | 6 | 19,073 | Rudy May | Joe Coleman | Rudy May | Joe Coleman | | 268 | 287 | -19 |
| 1974-06-24 | vs CLE | 71 | L 3-10 | 35-36 | 5 | 10,676 | Doc Medich | Fritz Peterson | Fritz Peterson | Doc Medich | | 271 | 297 | -26 |
| 1974-06-26 | vs CLE | 72 | L 2-3 | 35-37 | 6 | 16,573 | Pat Dobson | Steve Arlin | Steve Arlin | Pat Dobson | Tom Hilgendorf | 273 | 300 | -27 |
| 1974-06-29 | @ BAL | 73 | L 0-2 | 35-38 | 6 | 32,905 | Dick Tidrow | Dave McNally | Dave McNally | Dick Tidrow | | 273 | 302 | -29 |
| 1974-06-30 | @ BAL | 74 | L 0-3 | 35-39 | 6 | 21,186 | Rudy May | Mike Cuellar | Mike Cuellar | Rudy May | | 273 | 305 | -32 |
| 1974-07-01 | @ DET | 75 | L 3-4 | 35-40 | 6 | 21,532 | Doc Medich | Joe Coleman | John Hiller | Doc Medich | | 276 | 309 | -33 |
| 1974-07-02 | @ DET | 76 | L 2-4 | 35-41 | 6 | 13,866 | Pat Dobson | Luke Walker | Luke Walker | Pat Dobson | Jim Ray | 278 | 313 | -35 |
| 1974-07-03 | @ DET | 77 | L 6-8 | 35-42 | 6 | 17,846 | Dave Pagan | Mickey Lolich | John Hiller | Sparky Lyle | | 284 | 321 | -37 |
| 1974-07-04 | @ DET | 78 | W 6-4 | 36-42 | 6 | 15,058 | Dick Tidrow | Woodie Fryman | Dick Tidrow | John Hiller | | 290 | 325 | -35 |
| 1974-07-05 | @ TEX | 79 | W 14-2 | 37-42 | 6 | 20,958 | Rudy May | David Clyde | Rudy May | David Clyde | | 304 | 327 | -23 |
| 1974-07-06 | @ TEX | 80 | W 9-3 | 38-42 | 6 | 33,812 | Doc Medich | Jackie Brown | Doc Medich | Jackie Brown | | 313 | 330 | -17 |
| 1974-07-07 | @ TEX | 81 | L 2-3 | 38-43 | 6 | 11,251 | Pat Dobson | Steve Hargan | Steve Hargan | Pat Dobson | | 315 | 333 | -18 |
| 1974-07-08 | @ TEX | 82 | W 12-5 | 39-43 | 6 | 14,337 | Dick Tidrow | Fergie Jenkins | Dick Woodson | Don Stanhouse | | 327 | 338 | -11 |
| 1974-07-09 | @ KCA | 83 | W 8-2 | 40-43 | 6 | 17,511 | Dave Pagan | Paul Splittorff | Dave Pagan | Paul Splittorff | | 335 | 340 | -5 |
| 1974-07-10 | @ KCA | 84 | W 9-4 | 41-43 | 6 | 15,264 | Rudy May | Marty Pattin | Mike Wallace | Doug Bird | Sparky Lyle | 344 | 344 | 0 |
| 1974-07-11 | @ KCA | 85 | W 2-1 | 42-43 | 6 | 13,792 | Doc Medich | Nelson Briles | Doc Medich | Nelson Briles | | 346 | 345 | 1 |
| 1974-07-12 | vs OAK | 86 | W 3-0 | 43-43 | 6 | 29,332 | Pat Dobson | Ken Holtzman | Pat Dobson | Ken Holtzman | | 349 | 345 | 4 |
| 1974-07-13 | vs OAK | 87 | W 12-6 | 44-43 | 6 | 24,204 | Dick Tidrow | Vida Blue | Dick Tidrow | Vida Blue | Sparky Lyle | 361 | 351 | 10 |
| 1974-07-14 | vs OAK | 88 | L 3-7 | 44-45 | 6 | 0 | Dave Pagan | Catfish Hunter | Catfish Hunter | Cecil Upshaw | Rollie Fingers | 364 | 358 | 6 |
| 1974-07-14 | vs OAK | 89 | L 1-6 | 44-45 | 6 | 43,799 | Sam McDowell | Dave Hamilton | Dave Hamilton | Sam McDowell | Paul Lindblad | 365 | 364 | 1 |
| 1974-07-16 | vs TEX | 90 | W 2-0 | 45-45 | 5 | 19,288 | Doc Medich | David Clyde | Doc Medich | David Clyde | | 367 | 364 | 3 |
| 1974-07-17 | vs TEX | 91 | L 0-2 | 45-46 | 5 | 26,169 | Pat Dobson | Jim Bibby | Jim Bibby | Pat Dobson | | 367 | 366 | 1 |
| 1974-07-18 | vs KCA | 92 | W 10-6 | 46-46 | 5 | 12,615 | Dick Tidrow | Paul Splittorff | Mike Wallace | Paul Splittorff | | 377 | 372 | 5 |
| 1974-07-19 | vs KCA | 93 | L 4-5 | 46-47 | 5 | 15,703 | Sam McDowell | Bruce Dal Canton | Bruce Dal Canton | Sam McDowell | Doug Bird | 381 | 377 | 4 |
| 1974-07-20 | vs KCA | 94 | W 6-2 | 47-47 | 4 | 11,050 | Doc Medich | Steve Busby | Doc Medich | Steve Busby | | 387 | 379 | 8 |
| 1974-07-21 | vs KCA | 95 | W 5-4 | 48-47 | 4 | 36,825 | Pat Dobson | Nelson Briles | Sparky Lyle | Steve Mingori | | 392 | 383 | 9 |
| 1974-07-25 | vs MIL | 96 | W 1-0 | 49-47 | 4 | 13,893 | Doc Medich | Clyde Wright | Doc Medich | Clyde Wright | | 393 | 383 | 10 |
| 1974-07-26 | vs MIL | 97 | W 5-1 | 50-47 | 4 | 15,701 | Pat Dobson | Jim Colborn | Pat Dobson | Jim Colborn | Sparky Lyle | 398 | 384 | 14 |
| 1974-07-27 | @ BOS | 98 | L 4-5 | 50-48 | 4 | 34,834 | Dick Tidrow | Luis Tiant | Luis Tiant | Sparky Lyle | | 402 | 389 | 13 |
| 1974-07-28 | @ BOS | 99 | L 3-8 | 50-49 | 4 | 33,718 | Dave Pagan | Bill Lee | Bill Lee | Dave Pagan | | 405 | 397 | 8 |
| 1974-07-29 | @ BOS | 100 | L 1-2 | 50-50 | 4 | 30,889 | Sam McDowell | Roger Moret | Roger Moret | Sparky Lyle | | 406 | 399 | 7 |
| 1974-07-30 | @ MIL | 101 | L 2-3 | 50-52 | 5 | 0 | Doc Medich | Jim Colborn | Tom Murphy | Doc Medich | | 408 | 402 | 6 |
| 1974-07-30 | @ MIL | 102 | L 0-4 | 50-52 | 5 | 23,010 | Pat Dobson | Kevin Kobel | Kevin Kobel | Pat Dobson | | 408 | 406 | 2 |
| 1974-07-31 | @ MIL | 103 | W 4-3 | 51-52 | 5 | 14,836 | Dick Tidrow | Bill Champion | Dick Tidrow | Bill Travers | Sparky Lyle | 412 | 409 | 3 |
| 1974-08-01 | @ CLE | 104 | L 2-9 | 51-53 | 5 | 16,179 | Dave Pagan | Jim Perry | Jim Perry | Dave Pagan | | 414 | 418 | -4 |
| 1974-08-02 | @ CLE | 105 | L 2-8 | 51-54 | 6 | 18,842 | Sam McDowell | Fritz Peterson | Fritz Peterson | Sam McDowell | | 416 | 426 | -10 |
| 1974-08-03 | vs BOS | 106 | W 6-2 | 52-54 | 4 | 51,906 | Pat Dobson | Roger Moret | Pat Dobson | Roger Moret | | 422 | 428 | -6 |
| 1974-08-04 | vs BOS | 107 | L 3-7 | 52-55 | 5 | 21,147 | Doc Medich | Luis Tiant | Luis Tiant | Doc Medich | | 425 | 435 | -10 |
| 1974-08-05 | vs BOS | 108 | W 8-0 | 53-55 | 4 | 21,147 | Rudy May | Bill Lee | Rudy May | Bill Lee | | 433 | 435 | -2 |
| 1974-08-06 | vs BAL | 109 | L 1-4 | 53-56 | 4 | 16,818 | Dick Tidrow | Don Hood | Dave Johnson | Dick Tidrow | Grant Jackson | 434 | 439 | -5 |
| 1974-08-07 | vs BAL | 110 | W 4-3 | 54-56 | 4 | 9,972 | Pat Dobson | Ross Grimsley | Pat Dobson | Ross Grimsley | Cecil Upshaw | 438 | 442 | -4 |
| 1974-08-09 | @ CAL | 111 | L 1-7 | 54-57 | 4 | 10,203 | Doc Medich | Frank Tanana | Frank Tanana | Doc Medich | | 439 | 449 | -10 |
| 1974-08-10 | @ CAL | 112 | W 2-1 | 55-57 | 4 | 28,534 | Rudy May | Andy Hassler | Rudy May | Andy Hassler | | 441 | 450 | -9 |
| 1974-08-11 | @ CAL | 113 | W 5-4 | 56-57 | 4 | 9,192 | Dick Tidrow | Dick Lange | Dick Tidrow | Dick Lange | Cecil Upshaw | 446 | 454 | -8 |
| 1974-08-12 | @ OAK | 114 | L 2-3 | 56-58 | 4 | 27,137 | Pat Dobson | Catfish Hunter | Catfish Hunter | Pat Dobson | | 448 | 457 | -9 |
| 1974-08-13 | @ OAK | 115 | L 1-6 | 56-59 | 4 | 6,255 | Doc Medich | Ken Holtzman | Ken Holtzman | Doc Medich | | 449 | 463 | -14 |
| 1974-08-14 | @ OAK | 116 | W 4-1 | 57-59 | 4 | 7,676 | Rudy May | Vida Blue | Rudy May | Vida Blue | | 453 | 464 | -11 |
| 1974-08-16 | vs CHA | 117 | W 9-8 | 58-60 | 4 | 0 | Pat Dobson | Stan Bahnsen | Sparky Lyle | Terry Forster | | 462 | 472 | -10 |
| 1974-08-16 | vs CHA | 118 | L 2-4 | 58-60 | 4 | 22,245 | Dick Tidrow | Jack Kucek | Stan Bahnsen | Dick Tidrow | | 464 | 476 | -12 |
| 1974-08-17 | vs CHA | 119 | W 2-1 | 59-60 | 4 | 10,535 | Doc Medich | Bart Johnson | Doc Medich | Bart Johnson | | 466 | 477 | -11 |
| 1974-08-18 | vs CHA | 120 | W 9-4 | 60-60 | 4 | 18,493 | Rudy May | Wilbur Wood | Mike Wallace | Wilbur Wood | Sparky Lyle | 475 | 481 | -6 |
| 1974-08-19 | vs MIN | 121 | L 2-6 | 60-61 | 4 | 18,219 | Sam McDowell | Joe Decker | Joe Decker | Sam McDowell | | 477 | 487 | -10 |
| 1974-08-20 | vs MIN | 122 | W 2-1 | 61-61 | 4 | 12,284 | Pat Dobson | Bert Blyleven | Pat Dobson | Bert Blyleven | | 479 | 488 | -9 |
| 1974-08-21 | vs MIN | 123 | W 4-1 | 62-61 | 4 | 13,321 | Doc Medich | Bill Butler | Doc Medich | Bill Butler | | 483 | 489 | -6 |
| 1974-08-23 | vs CAL | 124 | W 10-4 | 63-61 | 4 | 13,893 | Rudy May | Skip Lockwood | Dick Tidrow | Skip Lockwood | | 493 | 493 | 0 |
| 1974-08-24 | vs CAL | 125 | W 3-1 | 64-61 | 2 | 10,535 | Pat Dobson | Frank Tanana | Pat Dobson | Frank Tanana | Cecil Upshaw | 496 | 494 | 2 |
| 1974-08-25 | vs CAL | 126 | W 2-1 | 65-61 | 2 | 17,745 | Larry Gura | Nolan Ryan | Larry Gura | Nolan Ryan | | 498 | 495 | 3 |
| 1974-08-26 | @ MIN | 127 | L 6-7 | 65-62 | 2 | 9,694 | Doc Medich | Bill Butler | Vic Albury | Doc Medich | Tom Burgmeier | 504 | 502 | 2 |
| 1974-08-27 | @ MIN | 128 | W 4-2 | 66-62 | 2 | 8,345 | Dick Tidrow | Bill Hands | Dick Tidrow | Bill Hands | | 508 | 504 | 4 |
| 1974-08-28 | @ MIN | 129 | W 5-0 | 67-62 | 2 | 6,545 | Pat Dobson | Joe Decker | Pat Dobson | Joe Decker | | 513 | 504 | 9 |
| 1974-08-30 | @ CHA | 130 | W 8-5 | 68-62 | 2 | 12,723 | Larry Gura | Jack Kucek | Cecil Upshaw | Rich Gossage | | 521 | 509 | 12 |
| 1974-08-31 | @ CHA | 131 | W 18-6 | 69-62 | 2 | 47,993 | Doc Medich | Jim Kaat | Doc Medich | Jim Kaat | Sparky Lyle | 539 | 515 | 24 |
| 1974-09-01 | @ CHA | 132 | W 7-5 | 70-62 | 2 | 15,096 | Pat Dobson | Bart Johnson | Pat Dobson | Bart Johnson | | 546 | 520 | 26 |
| 1974-09-02 | vs MIL | 133 | W 3-1 | 71-63 | 2 | 0 | Rudy May | Jim Colborn | Rudy May | Jim Colborn | | 549 | 521 | 28 |
| 1974-09-02 | vs MIL | 134 | L 2-3 | 71-63 | 2 | 26,121 | Dick Tidrow | Eduardo Rodriguez | Eduardo Rodriguez | Dick Tidrow | Tom Murphy | 551 | 524 | 27 |
| 1974-09-04 | vs MIL | 135 | W 3-0 | 72-63 | 2 | 8,362 | Doc Medich | Kevin Kobel | Doc Medich | Kevin Kobel | | 554 | 524 | 30 |
| 1974-09-06 | vs DET | 136 | W 6-2 | 73-63 | 1 | 20,712 | Pat Dobson | Mickey Lolich | Pat Dobson | Mickey Lolich | | 560 | 526 | 34 |
| 1974-09-07 | vs DET | 137 | L 3-8 | 74-64 | 1 | 0 | Rudy May | Luke Walker | Luke Walker | Rudy May | John Hiller | 563 | 534 | 29 |
| 1974-09-07 | vs DET | 138 | W 1-0 | 74-64 | 1 | 25,586 | Larry Gura | Woodie Fryman | Larry Gura | Woodie Fryman | | 564 | 534 | 30 |
| 1974-09-08 | vs DET | 139 | L 3-11 | 74-65 | 2 | 24,216 | Dick Tidrow | Joe Coleman | Joe Coleman | Dick Tidrow | | 567 | 545 | 22 |
| 1974-09-09 | @ BOS | 140 | W 6-3 | 75-65 | 1 | 34,981 | Doc Medich | Roger Moret | Doc Medich | Roger Moret | | 573 | 548 | 25 |
| 1974-09-10 | @ BOS | 141 | W 2-1 | 76-65 | 1 | 33,174 | Pat Dobson | Luis Tiant | Pat Dobson | Diego Segui | Sparky Lyle | 575 | 549 | 26 |
| 1974-09-11 | @ BAL | 142 | L 2-3 | 77-66 | 1 | 0 | Rudy May | Ross Grimsley | Grant Jackson | Cecil Upshaw | | 577 | 552 | 25 |
| 1974-09-11 | @ BAL | 143 | W 5-1 | 77-66 | 1 | 28,923 | Larry Gura | Don Hood | Larry Gura | Don Hood | | 582 | 553 | 29 |
| 1974-09-12 | @ BAL | 144 | W 3-0 | 78-66 | 1 | 14,909 | Mike Wallace | Jim Palmer | Mike Wallace | Jim Palmer | Dick Tidrow | 585 | 553 | 32 |
| 1974-09-13 | @ DET | 145 | L 3-6 | 78-67 | 1 | 10,963 | Doc Medich | Woodie Fryman | Woodie Fryman | Doc Medich | | 588 | 559 | 29 |
| 1974-09-14 | @ DET | 146 | W 10-7 | 79-67 | 1 | 12,662 | Pat Dobson | Mickey Lolich | Dick Tidrow | John Hiller | | 598 | 566 | 32 |
| 1974-09-15 | @ DET | 147 | W 10-2 | 80-67 | 1 | 11,849 | Larry Gura | Luke Walker | Larry Gura | Luke Walker | | 608 | 568 | 40 |
| 1974-09-17 | vs BAL | 148 | L 0-4 | 80-68 | 1 | 33,784 | Doc Medich | Jim Palmer | Jim Palmer | Doc Medich | | 608 | 572 | 36 |
| 1974-09-18 | vs BAL | 149 | L 4-10 | 80-69 | 1 | 31,093 | Pat Dobson | Mike Cuellar | Mike Cuellar | Pat Dobson | | 612 | 582 | 30 |
| 1974-09-19 | vs BAL | 150 | L 0-7 | 80-70 | 2 | 21,795 | Rudy May | Dave McNally | Dave McNally | Rudy May | | 612 | 589 | 23 |
| 1974-09-20 | vs CLE | 151 | W 5-4 | 82-70 | 2 | 0 | Dick Tidrow | Gaylord Perry | Sparky Lyle | Gaylord Perry | | 617 | 593 | 24 |
| 1974-09-20 | vs CLE | 152 | W 3-0 | 82-70 | 2 | 21,641 | Larry Gura | Fritz Peterson | Larry Gura | Fritz Peterson | | 620 | 593 | 27 |
| 1974-09-21 | vs CLE | 153 | W 14-7 | 83-70 | 1 | 14,648 | Doc Medich | Jim Perry | Rudy May | Tom Hilgendorf | | 634 | 600 | 34 |
| 1974-09-22 | vs CLE | 154 | W 2-1 | 84-70 | 1 | 36,540 | Pat Dobson | Bruce Ellingsen | Pat Dobson | Bruce Ellingsen | Sparky Lyle | 636 | 601 | 35 |
| 1974-09-24 | vs BOS | 155 | L 0-4 | 84-72 | 2 | 0 | Rudy May | Luis Tiant | Luis Tiant | Rudy May | | 636 | 605 | 31 |
| 1974-09-24 | vs BOS | 156 | L 2-4 | 84-72 | 2 | 46,448 | Larry Gura | Roger Moret | Roger Moret | Larry Gura | | 638 | 609 | 29 |
| 1974-09-25 | vs BOS | 157 | W 1-0 | 85-72 | 2 | 23,104 | Doc Medich | Bill Lee | Doc Medich | Bill Lee | | 639 | 609 | 30 |
| 1974-09-28 | @ CLE | 158 | W 9-3 | 87-72 | 2 | 0 | Pat Dobson | Gaylord Perry | Pat Dobson | Gaylord Perry | | 648 | 612 | 36 |
| 1974-09-28 | @ CLE | 159 | W 9-7 | 87-72 | 2 | 8,370 | Larry Gura | Bruce Ellingsen | Sparky Lyle | Tom Buskey | | 657 | 619 | 38 |
| 1974-09-29 | @ CLE | 160 | W 10-0 | 88-72 | 2 | 8,746 | Rudy May | Fritz Peterson | Rudy May | Fritz Peterson | | 667 | 619 | 48 |
| 1974-10-01 | @ MIL | 161 | L 2-3 | 88-73 | 2 | 4,155 | Doc Medich | Kevin Kobel | Tom Murphy | Doc Medich | | 669 | 622 | 47 |
| 1974-10-02 | @ MIL | 162 | W 2-1 | 89-73 | 2 | 3,694 | Pat Dobson | Jim Colborn | Pat Dobson | Jim Colborn | | 671 | 623 | 48 |