| 1974-04-06 | @ PHI | 1 | L 4-5 | 0-1 | 5 | 40,222 | Tom Seaver | Steve Carlton | Mac Scarce | Tug McGraw | | 4 | 5 | -1 |
| 1974-04-07 | @ PHI | 2 | W 9-2 | 1-1 | 2 | 16,441 | Jon Matlack | Jim Lonborg | Jon Matlack | Jim Lonborg | Tug McGraw | 13 | 7 | 6 |
| 1974-04-10 | vs SLN | 3 | W 3-2 | 2-1 | 3 | 17,154 | Jerry Koosman | John Curtis | Jerry Koosman | John Curtis | Bob Apodaca | 16 | 9 | 7 |
| 1974-04-11 | vs SLN | 4 | L 7-8 | 2-3 | 4 | 0 | Tom Seaver | Bob Gibson | Mike Garman | Craig Swan | | 23 | 17 | 6 |
| 1974-04-11 | vs SLN | 5 | L 3-4 | 2-3 | 4 | 34,382 | George Stone | Alan Foster | Rich Folkers | Bob Apodaca | | 26 | 21 | 5 |
| 1974-04-14 | vs PHI | 6 | L 1-2 | 2-5 | 5 | 0 | Jon Matlack | Jim Lonborg | Mike Wallace | Tug McGraw | | 27 | 23 | 4 |
| 1974-04-14 | vs PHI | 7 | L 3-5 | 2-5 | 5 | 14,201 | Jerry Koosman | Ron Schueler | Mac Scarce | Bob Miller | | 30 | 28 | 2 |
| 1974-04-16 | @ MON | 8 | L 1-4 | 2-6 | 5 | 18,425 | Tom Seaver | Steve Renko | Steve Renko | Tom Seaver | | 31 | 32 | -1 |
| 1974-04-17 | @ MON | 9 | L 4-7 | 2-7 | 5 | 10,007 | George Stone | Steve Rogers | Steve Rogers | George Stone | | 35 | 39 | -4 |
| 1974-04-18 | @ MON | 10 | L 5-8 | 2-8 | 5 | 8,390 | Ray Sadecki | Mike Torrez | Mike Torrez | Ray Sadecki | Chuck Taylor | 40 | 47 | -7 |
| 1974-04-20 | vs PIT | 11 | W 5-2 | 3-8 | 5 | 18,070 | Jerry Koosman | Bob Moose | Jerry Koosman | Bob Moose | | 45 | 49 | -4 |
| 1974-04-21 | vs PIT | 12 | L 0-7 | 3-9 | 5 | 23,375 | Tom Seaver | Ken Brett | Ken Brett | Tom Seaver | | 45 | 56 | -11 |
| 1974-04-23 | @ SDN | 13 | L 2-10 | 3-10 | 5 | 7,819 | Jon Matlack | Randy Jones | Randy Jones | Jon Matlack | | 47 | 66 | -19 |
| 1974-04-24 | @ SDN | 14 | L 3-4 | 3-11 | 6 | 8,322 | George Stone | Steve Arlin | Mike Corkins | Bob Apodaca | | 50 | 70 | -20 |
| 1974-04-25 | @ SDN | 15 | W 5-2 | 4-11 | 5 | 8,307 | Jerry Koosman | Bill Greif | Jerry Koosman | Bill Greif | | 55 | 72 | -17 |
| 1974-04-26 | @ SFN | 16 | W 6-0 | 5-11 | 5 | 8,210 | Tom Seaver | Ron Bryant | Tom Seaver | Ron Bryant | | 61 | 72 | -11 |
| 1974-04-27 | @ SFN | 17 | L 3-11 | 5-12 | 5 | 9,727 | Craig Swan | John D'Acquisto | Elias Sosa | Craig Swan | | 64 | 83 | -19 |
| 1974-04-28 | @ SFN | 18 | W 6-0 | 7-12 | 5 | 0 | Jon Matlack | Tom Bradley | Jon Matlack | Tom Bradley | | 70 | 83 | -13 |
| 1974-04-28 | @ SFN | 19 | W 6-4 | 7-12 | 5 | 18,970 | Harry Parker | Charlie Williams | Harry Parker | Randy Moffitt | Bob Miller | 76 | 87 | -11 |
| 1974-04-29 | @ LAN | 20 | L 7-8 | 7-13 | 5 | 21,934 | George Stone | Don Sutton | Jim Brewer | George Stone | Mike Marshall | 83 | 95 | -12 |
| 1974-04-30 | @ LAN | 21 | W 8-7 | 8-13 | 5 | 24,049 | Jerry Koosman | Tommy John | Bob Miller | Jim Brewer | | 91 | 102 | -11 |
| 1974-05-01 | @ LAN | 22 | L 1-2 | 8-14 | 5 | 27,283 | Tom Seaver | Andy Messersmith | Jim Brewer | Harry Parker | | 92 | 104 | -12 |
| 1974-05-04 | vs SDN | 23 | W 6-3 | 9-14 | 5 | 46,195 | Jon Matlack | Randy Jones | Jon Matlack | Randy Jones | | 98 | 107 | -9 |
| 1974-05-05 | vs SDN | 24 | L 4-5 | 10-15 | 5 | 0 | Jerry Koosman | Bill Greif | Larry Hardy | Tug McGraw | Vicente Romo | 102 | 112 | -10 |
| 1974-05-05 | vs SDN | 25 | W 6-4 | 10-15 | 5 | 25,439 | Craig Swan | Mike Corkins | Ray Sadecki | Larry Hardy | | 108 | 116 | -8 |
| 1974-05-07 | vs SFN | 26 | L 3-4 | 10-17 | 5 | 0 | Tom Seaver | Ron Bryant | Elias Sosa | Tom Seaver | | 111 | 120 | -9 |
| 1974-05-07 | vs SFN | 27 | L 0-3 | 10-17 | 5 | 15,352 | George Stone | Jim Barr | Jim Barr | George Stone | Randy Moffitt | 111 | 123 | -12 |
| 1974-05-08 | vs SFN | 28 | W 4-2 | 11-17 | 5 | 13,421 | Jon Matlack | John D'Acquisto | Jon Matlack | John D'Acquisto | | 115 | 125 | -10 |
| 1974-05-10 | @ CHN | 29 | W 7-2 | 12-17 | 5 | 4,385 | Jerry Koosman | Burt Hooton | Jerry Koosman | Burt Hooton | | 122 | 127 | -5 |
| 1974-05-11 | @ CHN | 30 | W 6-3 | 13-17 | 4 | 9,481 | Craig Swan | Ken Frailing | Craig Swan | Ken Frailing | | 128 | 130 | -2 |
| 1974-05-12 | @ CHN | 31 | L 3-4 | 13-18 | 5 | 9,581 | Tom Seaver | Steve Stone | Bill Bonham | Tom Seaver | | 131 | 134 | -3 |
| 1974-05-13 | @ SLN | 32 | W 5-3 | 14-18 | 5 | 12,653 | Bob Apodaca | Bob Gibson | Bob Apodaca | Bob Gibson | Harry Parker | 136 | 137 | -1 |
| 1974-05-15 | @ SLN | 33 | L 1-10 | 14-19 | 5 | 12,096 | Jerry Koosman | Lynn McGlothen | Lynn McGlothen | Jerry Koosman | | 137 | 147 | -10 |
| 1974-05-16 | @ SLN | 34 | W 6-4 | 15-19 | 4 | 14,307 | George Stone | John Curtis | George Stone | John Curtis | | 143 | 151 | -8 |
| 1974-05-17 | vs MON | 35 | W 5-0 | 16-19 | 4 | 23,200 | Tom Seaver | Balor Moore | Tom Seaver | Balor Moore | | 148 | 151 | -3 |
| 1974-05-18 | vs MON | 36 | W 6-0 | 17-19 | 4 | 48,736 | Jon Matlack | Steve Rogers | Jon Matlack | Steve Rogers | | 154 | 151 | 3 |
| 1974-05-19 | vs MON | 37 | L 4-7 | 17-21 | 4 | 0 | Craig Swan | Steve Renko | Steve Renko | Craig Swan | Chuck Taylor | 158 | 158 | 0 |
| 1974-05-19 | vs MON | 38 | L 0-5 | 17-21 | 4 | 40,641 | Jerry Koosman | Ernie McAnally | Ernie McAnally | Jerry Koosman | | 158 | 163 | -5 |
| 1974-05-20 | vs CHN | 39 | L 1-2 | 17-22 | 4 | 11,225 | Harry Parker | Burt Hooton | Burt Hooton | Harry Parker | | 159 | 165 | -6 |
| 1974-05-21 | vs CHN | 40 | W 10-5 | 18-22 | 4 | 11,995 | George Stone | Ken Frailing | George Stone | Ken Frailing | | 169 | 170 | -1 |
| 1974-05-22 | vs CHN | 41 | L 6-9 | 18-23 | 4 | 16,196 | Tom Seaver | Steve Stone | Dave LaRoche | Bob Apodaca | | 175 | 179 | -4 |
| 1974-05-24 | @ PIT | 42 | L 1-4 | 18-24 | 4 | 12,257 | Jon Matlack | Jerry Reuss | Jerry Reuss | Jon Matlack | | 176 | 183 | -7 |
| 1974-05-25 | @ PIT | 43 | W 4-3 | 19-24 | 4 | 11,260 | Jerry Koosman | Dock Ellis | Jerry Koosman | Dock Ellis | | 180 | 186 | -6 |
| 1974-05-26 | @ PIT | 44 | W 5-3 | 20-24 | 4 | 15,573 | Craig Swan | Jim Rooker | Ray Sadecki | Dave Giusti | Harry Parker | 185 | 189 | -4 |
| 1974-05-27 | @ CIN | 45 | L 2-4 | 20-25 | 4 | 20,057 | Tom Seaver | Fred Norman | Fred Norman | Tom Seaver | | 187 | 193 | -6 |
| 1974-05-28 | @ CIN | 46 | L 2-7 | 20-26 | 4 | 14,017 | George Stone | Clay Kirby | Clay Kirby | George Stone | | 189 | 200 | -11 |
| 1974-05-29 | @ CIN | 47 | L 2-3 | 20-27 | 4 | 16,339 | Jon Matlack | Don Gullett | Clay Carroll | Harry Parker | | 191 | 203 | -12 |
| 1974-05-31 | vs HOU | 48 | L 1-7 | 20-28 | 5 | 20,736 | Jerry Koosman | Don Wilson | Don Wilson | Jerry Koosman | Fred Scherman | 192 | 210 | -18 |
| 1974-06-01 | vs HOU | 49 | W 3-1 | 21-28 | 4 | 18,994 | Tom Seaver | Dave Roberts | Tom Seaver | Dave Roberts | | 195 | 211 | -16 |
| 1974-06-03 | vs CIN | 50 | L 2-5 | 21-29 | 5 | 23,065 | Jon Matlack | Clay Kirby | Clay Kirby | Jon Matlack | | 197 | 216 | -19 |
| 1974-06-04 | vs CIN | 51 | L 3-6 | 21-30 | 5 | 23,333 | Jerry Koosman | Don Gullett | Pedro Borbon | Ray Sadecki | | 200 | 222 | -22 |
| 1974-06-06 | vs CIN | 52 | W 4-3 | 22-30 | 4 | 19,502 | Tom Seaver | Roger Nelson | Ray Sadecki | Pedro Borbon | | 204 | 225 | -21 |
| 1974-06-07 | @ HOU | 53 | L 0-1 | 22-31 | 4 | 15,406 | Harry Parker | Don Wilson | Don Wilson | Harry Parker | | 204 | 226 | -22 |
| 1974-06-08 | @ HOU | 54 | W 6-5 | 23-31 | 4 | 18,984 | Jon Matlack | Dave Roberts | Ray Sadecki | Jim York | | 210 | 231 | -21 |
| 1974-06-09 | @ HOU | 55 | L 1-11 | 23-32 | 4 | 16,880 | Jerry Koosman | Tom Griffin | Tom Griffin | Jerry Koosman | | 211 | 242 | -31 |
| 1974-06-11 | @ ATL | 56 | L 3-4 | 23-33 | 5 | 45,296 | Tom Seaver | Buzz Capra | Danny Frisella | Bob Apodaca | | 214 | 246 | -32 |
| 1974-06-12 | @ ATL | 57 | L 0-1 | 23-34 | 5 | 10,166 | Harry Parker | Carl Morton | Carl Morton | Harry Parker | | 214 | 247 | -33 |
| 1974-06-14 | vs LAN | 58 | L 2-3 | 23-35 | 5 | 42,211 | Jon Matlack | Tommy John | Tommy John | Jon Matlack | Mike Marshall | 216 | 250 | -34 |
| 1974-06-15 | vs LAN | 59 | W 4-1 | 24-35 | 5 | 37,092 | Jerry Koosman | Doug Rau | Jerry Koosman | Doug Rau | | 220 | 251 | -31 |
| 1974-06-16 | vs LAN | 60 | L 1-7 | 24-36 | 6 | 35,994 | Tom Seaver | Andy Messersmith | Andy Messersmith | Tom Seaver | | 221 | 258 | -37 |
| 1974-06-17 | vs ATL | 61 | L 1-8 | 24-37 | 6 | 35,994 | Harry Parker | Phil Niekro | Phil Niekro | Harry Parker | | 222 | 266 | -44 |
| 1974-06-18 | vs ATL | 62 | L 1-6 | 24-38 | 6 | 33,403 | George Stone | Roric Harrison | Roric Harrison | George Stone | | 223 | 272 | -49 |
| 1974-06-19 | vs ATL | 63 | L 0-5 | 24-39 | 6 | 24,159 | Jon Matlack | Buzz Capra | Buzz Capra | Jon Matlack | Tom House | 223 | 277 | -54 |
| 1974-06-20 | @ PHI | 64 | W 2-1 | 25-39 | 6 | 22,210 | Jerry Koosman | Dick Ruthven | Jerry Koosman | Dick Ruthven | | 225 | 278 | -53 |
| 1974-06-21 | @ PHI | 65 | W 3-1 | 26-39 | 6 | 28,262 | Tom Seaver | Steve Carlton | Tom Seaver | Steve Carlton | Tug McGraw | 228 | 279 | -51 |
| 1974-06-22 | @ PHI | 66 | L 2-5 | 26-41 | 6 | 0 | Harry Parker | Ron Schueler | Ron Schueler | Harry Parker | | 230 | 284 | -54 |
| 1974-06-22 | @ PHI | 67 | L 5-8 | 26-41 | 6 | 51,197 | George Stone | Wayne Twitchell | Wayne Twitchell | George Stone | Jesus Hernaiz | 235 | 292 | -57 |
| 1974-06-24 | @ CHN | 68 | W 4-2 | 27-41 | 6 | 9,860 | Jon Matlack | Jim Todd | Bob Miller | Oscar Zamora | | 239 | 294 | -55 |
| 1974-06-25 | @ CHN | 69 | W 5-1 | 28-41 | 6 | 13,217 | Jerry Koosman | Rick Reuschel | Jerry Koosman | Rick Reuschel | | 244 | 295 | -51 |
| 1974-06-26 | @ CHN | 70 | W 5-4 | 29-41 | 6 | 15,275 | Harry Parker | Steve Stone | Jack Aker | Burt Hooton | | 249 | 299 | -50 |
| 1974-06-27 | vs SLN | 71 | L 1-6 | 29-42 | 6 | 19,952 | Ray Sadecki | Lynn McGlothen | Lynn McGlothen | Ray Sadecki | | 250 | 305 | -55 |
| 1974-06-29 | vs SLN | 72 | W 4-0 | 30-42 | 6 | 37,317 | Jon Matlack | John Curtis | Jon Matlack | John Curtis | | 254 | 305 | -51 |
| 1974-06-30 | vs SLN | 73 | L 2-5 | 30-44 | 6 | 0 | Jerry Koosman | Alan Foster | Alan Foster | Jerry Koosman | Al Hrabosky | 256 | 310 | -54 |
| 1974-06-30 | vs SLN | 74 | L 3-5 | 30-44 | 6 | 40,009 | George Stone | Bob Gibson | Orlando Pena | Tug McGraw | | 259 | 315 | -56 |
| 1974-07-02 | vs PHI | 75 | W 4-2 | 31-44 | 6 | 20,724 | Tom Seaver | Dick Ruthven | Tom Seaver | Dick Ruthven | Jack Aker | 263 | 317 | -54 |
| 1974-07-03 | vs PHI | 76 | W 6-2 | 32-44 | 6 | 15,758 | Harry Parker | Jim Lonborg | Harry Parker | Jim Lonborg | | 269 | 319 | -50 |
| 1974-07-04 | vs PHI | 77 | W 5-3 | 33-45 | 6 | 0 | Jon Matlack | Ron Schueler | Jon Matlack | Ron Schueler | | 274 | 322 | -48 |
| 1974-07-04 | vs PHI | 78 | L 2-6 | 33-45 | 6 | 26,811 | Ray Sadecki | Wayne Twitchell | Wayne Twitchell | Ray Sadecki | | 276 | 328 | -52 |
| 1974-07-05 | vs SFN | 79 | W 3-2 | 34-45 | 6 | 19,343 | Jerry Koosman | Jim Barr | Jerry Koosman | Jim Barr | | 279 | 330 | -51 |
| 1974-07-06 | vs SFN | 80 | L 2-5 | 34-46 | 6 | 23,763 | George Stone | John D'Acquisto | John D'Acquisto | George Stone | Randy Moffitt | 281 | 335 | -54 |
| 1974-07-07 | vs SFN | 81 | W 6-0 | 35-46 | 6 | 27,190 | Tom Seaver | Ron Bryant | Tom Seaver | Ron Bryant | Bob Apodaca | 287 | 335 | -48 |
| 1974-07-08 | vs SDN | 82 | W 2-1 | 36-46 | 6 | 16,791 | Harry Parker | Dave Freisleben | Harry Parker | Dave Freisleben | Bob Miller | 289 | 336 | -47 |
| 1974-07-09 | vs SDN | 83 | L 4-5 | 36-47 | 6 | 19,264 | Jon Matlack | Dan Spillner | Dan Spillner | Jon Matlack | Vicente Romo | 293 | 341 | -48 |
| 1974-07-10 | vs SDN | 84 | L 1-8 | 36-48 | 6 | 16,962 | Jerry Koosman | Bill Greif | Bill Greif | Jerry Koosman | | 294 | 349 | -55 |
| 1974-07-12 | @ LAN | 85 | W 5-2 | 37-48 | 6 | 50,129 | Bob Apodaca | Tommy John | Bob Apodaca | Tommy John | Jack Aker | 299 | 351 | -52 |
| 1974-07-13 | @ LAN | 86 | L 1-2 | 37-49 | 6 | 41,658 | Harry Parker | Andy Messersmith | Andy Messersmith | Harry Parker | | 300 | 353 | -53 |
| 1974-07-14 | @ LAN | 87 | W 4-1 | 38-49 | 4 | 33,389 | Jon Matlack | Doug Rau | Jon Matlack | Doug Rau | | 304 | 354 | -50 |
| 1974-07-16 | @ SFN | 88 | L 4-9 | 38-50 | 6 | 3,976 | Jerry Koosman | Jim Barr | Jim Barr | Jerry Koosman | | 308 | 363 | -55 |
| 1974-07-17 | @ SFN | 89 | L 2-6 | 38-51 | 6 | 10,016 | Bob Apodaca | John D'Acquisto | John D'Acquisto | Bob Apodaca | | 310 | 369 | -59 |
| 1974-07-19 | @ SDN | 90 | W 4-2 | 39-51 | 6 | 11,480 | Jon Matlack | Dan Spillner | Jon Matlack | Dan Spillner | | 314 | 371 | -57 |
| 1974-07-20 | @ SDN | 91 | W 10-2 | 40-51 | 6 | 31,342 | Jerry Koosman | Bill Laxton | Jerry Koosman | Lowell Palmer | | 324 | 373 | -49 |
| 1974-07-21 | @ SDN | 92 | L 3-7 | 40-52 | 6 | 7,481 | Harry Parker | Bill Greif | Bill Greif | Harry Parker | | 327 | 380 | -53 |
| 1974-07-25 | @ SLN | 93 | L 3-4 | 40-54 | 6 | 0 | Jerry Koosman | Bob Gibson | Rich Folkers | Jack Aker | | 330 | 384 | -54 |
| 1974-07-25 | @ SLN | 94 | L 1-4 | 40-54 | 6 | 27,992 | Jon Matlack | Alan Foster | Alan Foster | Jon Matlack | | 331 | 388 | -57 |
| 1974-07-26 | @ SLN | 95 | W 3-0 | 41-54 | 6 | 20,783 | Tom Seaver | Lynn McGlothen | Tom Seaver | Lynn McGlothen | | 334 | 388 | -54 |
| 1974-07-27 | vs MON | 96 | W 8-5 | 42-54 | 6 | 32,565 | Bob Apodaca | Mike Torrez | Bob Apodaca | Mike Torrez | | 342 | 393 | -51 |
| 1974-07-28 | vs MON | 97 | W 4-1 | 43-54 | 5 | 26,306 | Harry Parker | Ernie McAnally | Tug McGraw | Ernie McAnally | | 346 | 394 | -48 |
| 1974-07-29 | vs MON | 98 | W 4-3 | 44-54 | 5 | 17,343 | George Stone | Steve Rogers | Jack Aker | Steve Rogers | | 350 | 397 | -47 |
| 1974-07-30 | vs PIT | 99 | L 0-6 | 45-55 | 5 | 0 | Jon Matlack | Jim Rooker | Jim Rooker | Jon Matlack | | 350 | 403 | -53 |
| 1974-07-30 | vs PIT | 100 | W 4-3 | 45-55 | 5 | 39,246 | Jerry Koosman | Bruce Kison | Jerry Koosman | Bruce Kison | | 354 | 406 | -52 |
| 1974-07-31 | vs PIT | 101 | L 3-8 | 45-56 | 5 | 23,281 | Tom Seaver | Dock Ellis | Dock Ellis | Tom Seaver | | 357 | 414 | -57 |
| 1974-08-01 | vs CHN | 102 | L 4-7 | 45-58 | 5 | 0 | Bob Apodaca | Steve Stone | Burt Hooton | Tug McGraw | | 361 | 421 | -60 |
| 1974-08-01 | vs CHN | 103 | L 1-3 | 45-58 | 5 | 26,230 | Ray Sadecki | Dave LaRoche | Dave LaRoche | Ray Sadecki | Oscar Zamora | 362 | 424 | -62 |
| 1974-08-03 | @ MON | 104 | W 3-0 | 46-58 | 5 | 21,089 | Jon Matlack | Steve Renko | Jon Matlack | Steve Renko | | 365 | 424 | -59 |
| 1974-08-05 | @ MON | 105 | W 10-4 | 47-58 | 5 | 20,118 | Tom Seaver | Dennis Blair | Tug McGraw | Dennis Blair | | 375 | 428 | -53 |
| 1974-08-06 | @ PIT | 106 | L 8-9 | 47-59 | 5 | 12,441 | Jerry Koosman | Ken Brett | Daryl Patterson | Tug McGraw | | 383 | 437 | -54 |
| 1974-08-07 | @ PIT | 107 | L 1-10 | 47-60 | 5 | 13,360 | Harry Parker | Larry Demery | Larry Demery | Harry Parker | | 384 | 447 | -63 |
| 1974-08-08 | @ PIT | 108 | L 3-4 | 47-61 | 5 | 11,191 | Jon Matlack | Jerry Reuss | Jerry Reuss | Jon Matlack | | 387 | 451 | -64 |
| 1974-08-09 | vs CIN | 109 | W 4-1 | 48-61 | 5 | 27,391 | Bob Apodaca | Fred Norman | Bob Apodaca | Fred Norman | | 391 | 452 | -61 |
| 1974-08-10 | vs CIN | 110 | L 3-5 | 48-62 | 5 | 40,359 | Tom Seaver | Don Gullett | Clay Carroll | Ray Sadecki | | 394 | 457 | -63 |
| 1974-08-11 | vs CIN | 111 | L 4-10 | 48-63 | 5 | 40,588 | Jerry Koosman | Tom Carroll | Tom Carroll | Jerry Koosman | Tom Hall | 398 | 467 | -69 |
| 1974-08-12 | vs LAN | 112 | W 3-1 | 49-63 | 5 | 33,431 | Harry Parker | Andy Messersmith | Harry Parker | Andy Messersmith | | 401 | 468 | -67 |
| 1974-08-13 | vs LAN | 113 | W 3-0 | 50-63 | 5 | 35,870 | Jon Matlack | Al Downing | Jon Matlack | Al Downing | | 404 | 468 | -64 |
| 1974-08-14 | vs LAN | 114 | W 3-2 | 51-63 | 5 | 33,125 | Tom Seaver | Doug Rau | Tug McGraw | Mike Marshall | | 407 | 470 | -63 |
| 1974-08-16 | @ CIN | 115 | W 2-1 | 52-63 | 5 | 36,480 | Jerry Koosman | Tom Carroll | Tug McGraw | Will McEnaney | | 409 | 471 | -62 |
| 1974-08-17 | @ CIN | 116 | L 2-6 | 52-64 | 5 | 47,274 | Harry Parker | Jack Billingham | Jack Billingham | Harry Parker | | 411 | 477 | -66 |
| 1974-08-18 | @ CIN | 117 | L 5-6 | 52-65 | 5 | 45,025 | Jon Matlack | Fred Norman | Clay Carroll | Jon Matlack | Will McEnaney | 416 | 483 | -67 |
| 1974-08-19 | @ HOU | 118 | L 1-2 | 52-66 | 5 | 10,619 | Tom Seaver | Don Wilson | Ken Forsch | Tom Seaver | | 417 | 485 | -68 |
| 1974-08-20 | @ HOU | 119 | L 2-6 | 52-67 | 5 | 11,539 | Bob Apodaca | J.R. Richard | J.R. Richard | Ray Sadecki | Mike Cosgrove | 419 | 491 | -72 |
| 1974-08-21 | @ HOU | 120 | W 10-2 | 53-67 | 5 | 9,663 | Jerry Koosman | Tom Griffin | Jerry Koosman | Tom Griffin | | 429 | 493 | -64 |
| 1974-08-23 | @ ATL | 121 | L 3-4 | 53-69 | 5 | 0 | Jon Matlack | Ron Reed | Max Leon | Tug McGraw | | 432 | 497 | -65 |
| 1974-08-23 | @ ATL | 122 | L 0-6 | 53-69 | 5 | 12,860 | Harry Parker | Lew Krausse | Lew Krausse | Harry Parker | Tom House | 432 | 503 | -71 |
| 1974-08-24 | @ ATL | 123 | L 3-4 | 53-70 | 5 | 34,060 | Tom Seaver | Carl Morton | Carl Morton | Bob Miller | | 435 | 507 | -72 |
| 1974-08-25 | @ ATL | 124 | W 1-0 | 54-70 | 5 | 9,358 | Ray Sadecki | Phil Niekro | Ray Sadecki | Phil Niekro | | 436 | 507 | -71 |
| 1974-08-26 | vs HOU | 125 | W 5-4 | 55-70 | 5 | 15,104 | Jerry Koosman | J.R. Richard | Jerry Koosman | Mike Cosgrove | | 441 | 511 | -70 |
| 1974-08-27 | vs HOU | 126 | W 4-2 | 56-70 | 5 | 20,934 | Tug McGraw | Tom Griffin | Tug McGraw | Tom Griffin | Harry Parker | 445 | 513 | -68 |
| 1974-08-28 | vs HOU | 127 | L 2-3 | 56-71 | 5 | 13,987 | Jon Matlack | Larry Dierker | Ramon de los Santos | Jerry Cram | Jim York | 447 | 516 | -69 |
| 1974-08-29 | vs HOU | 128 | W 7-0 | 57-71 | 5 | 42,814 | Tom Seaver | Dave Roberts | Tom Seaver | Dave Roberts | | 454 | 516 | -62 |
| 1974-08-30 | vs ATL | 129 | W 4-2 | 58-71 | 5 | 32,482 | Ray Sadecki | Buzz Capra | Ray Sadecki | Buzz Capra | | 458 | 518 | -60 |
| 1974-08-31 | vs ATL | 130 | W 6-5 | 59-71 | 5 | 31,211 | Jerry Koosman | Danny Frisella | Bob Apodaca | Max Leon | Harry Parker | 464 | 523 | -59 |
| 1974-09-01 | vs ATL | 131 | W 3-0 | 60-71 | 5 | 33,879 | Tug McGraw | Carl Morton | Tug McGraw | Carl Morton | | 467 | 523 | -56 |
| 1974-09-03 | @ CHN | 132 | W 2-0 | 62-71 | 4 | 0 | Jon Matlack | Bill Bonham | Jon Matlack | Bill Bonham | | 469 | 523 | -54 |
| 1974-09-03 | @ CHN | 133 | W 11-4 | 62-71 | 4 | 3,731 | Tom Seaver | Tom Dettore | Tom Seaver | Tom Dettore | | 480 | 527 | -47 |
| 1974-09-04 | @ CHN | 134 | W 4-2 | 63-71 | 4 | 1,953 | Ray Sadecki | Steve Stone | Ray Sadecki | Steve Stone | Bob Apodaca | 484 | 529 | -45 |
| 1974-09-06 | @ SLN | 135 | L 0-3 | 63-72 | 4 | 21,832 | Jerry Koosman | Bob Forsch | Bob Forsch | Jerry Koosman | | 484 | 532 | -48 |
| 1974-09-07 | @ SLN | 136 | L 1-2 | 63-73 | 4 | 36,007 | Jon Matlack | Bob Gibson | Bob Gibson | Jon Matlack | | 485 | 534 | -49 |
| 1974-09-08 | @ SLN | 137 | W 5-3 | 64-73 | 4 | 34,304 | Tom Seaver | Lynn McGlothen | Tom Seaver | Lynn McGlothen | | 490 | 537 | -47 |
| 1974-09-09 | vs MON | 138 | W 7-1 | 65-73 | 4 | 9,960 | Ray Sadecki | Dennis Blair | Ray Sadecki | Dennis Blair | | 497 | 538 | -41 |
| 1974-09-10 | vs MON | 139 | L 4-6 | 65-74 | 4 | 9,951 | Tug McGraw | Ernie McAnally | Don Carrithers | Tug McGraw | Dale Murray | 501 | 544 | -43 |
| 1974-09-11 | vs SLN | 140 | L 3-4 | 65-75 | 4 | 13,460 | Jerry Koosman | Bob Forsch | Sonny Siebert | Hank Webb | | 504 | 548 | -44 |
| 1974-09-12 | vs SLN | 141 | L 5-12 | 65-76 | 4 | 11,747 | Jon Matlack | Bob Gibson | Bob Gibson | Jon Matlack | Al Hrabosky | 509 | 560 | -51 |
| 1974-09-13 | vs CHN | 142 | W 6-0 | 66-77 | 5 | 0 | Tom Seaver | Rick Reuschel | Tom Seaver | Rick Reuschel | | 515 | 560 | -45 |
| 1974-09-13 | vs CHN | 143 | L 3-4 | 66-77 | 5 | 19,009 | Nino Espinosa | Steve Stone | Jim Todd | Bob Apodaca | | 518 | 564 | -46 |
| 1974-09-14 | vs CHN | 144 | L 0-12 | 66-78 | 5 | 14,761 | Ray Sadecki | Burt Hooton | Burt Hooton | Ray Sadecki | | 518 | 576 | -58 |
| 1974-09-15 | vs CHN | 145 | L 4-5 | 66-79 | 5 | 17,288 | Hank Webb | Bill Bonham | Dave LaRoche | Tug McGraw | Oscar Zamora | 522 | 581 | -59 |
| 1974-09-16 | @ MON | 146 | L 2-3 | 67-80 | 5 | 0 | Jerry Koosman | Mike Torrez | Mike Torrez | Jerry Koosman | John Montague | 524 | 584 | -60 |
| 1974-09-16 | @ MON | 147 | W 3-2 | 67-80 | 5 | 9,166 | Randy Sterling | Don Carrithers | Randy Sterling | Don Carrithers | Tug McGraw | 527 | 586 | -59 |
| 1974-09-18 | @ MON | 148 | L 2-3 | 67-82 | 5 | 0 | Jon Matlack | Steve Rogers | Steve Rogers | Jon Matlack | Dale Murray | 529 | 589 | -60 |
| 1974-09-18 | @ MON | 149 | L 0-4 | 67-82 | 5 | 9,288 | Tom Seaver | Dennis Blair | Dennis Blair | Tom Seaver | Dale Murray | 529 | 593 | -64 |
| 1974-09-20 | @ PIT | 150 | L 3-4 | 67-83 | 5 | 11,683 | Ray Sadecki | Ken Brett | Ramon Hernandez | Tug McGraw | | 532 | 597 | -65 |
| 1974-09-21 | @ PIT | 151 | W 4-2 | 68-83 | 5 | 7,160 | Jerry Koosman | Juan Pizarro | Jerry Koosman | Juan Pizarro | | 536 | 599 | -63 |
| 1974-09-22 | @ PIT | 152 | W 4-0 | 69-83 | 5 | 27,915 | Jon Matlack | Jerry Reuss | Jon Matlack | Jerry Reuss | | 540 | 599 | -59 |
| 1974-09-24 | @ PHI | 153 | L 3-6 | 69-84 | 5 | 11,165 | Hank Webb | Steve Carlton | Steve Carlton | Hank Webb | Gene Garber | 543 | 605 | -62 |
| 1974-09-25 | @ PHI | 154 | L 2-6 | 69-86 | 5 | 0 | Tom Seaver | Ron Schueler | Ron Schueler | Tom Seaver | Larry Christenson | 545 | 611 | -66 |
| 1974-09-25 | @ PHI | 155 | L 3-6 | 69-86 | 5 | 16,221 | Randy Sterling | Wayne Twitchell | Tom Underwood | Randy Sterling | Gene Garber | 548 | 617 | -69 |
| 1974-09-26 | vs PIT | 156 | L 5-11 | 69-87 | 5 | 9,250 | Jerry Koosman | Juan Pizarro | Juan Pizarro | Jerry Koosman | | 553 | 628 | -75 |
| 1974-09-27 | vs PIT | 157 | L 1-2 | 69-88 | 5 | 17,440 | Jon Matlack | Jerry Reuss | Jerry Reuss | Jon Matlack | | 554 | 630 | -76 |
| 1974-09-28 | vs PIT | 158 | L 3-7 | 69-89 | 5 | 13,059 | Tug McGraw | Jim Rooker | Jim Rooker | Tug McGraw | Ramon Hernandez | 557 | 637 | -80 |
| 1974-09-29 | vs PIT | 159 | W 7-2 | 70-89 | 5 | 50,653 | Bob Apodaca | Ken Brett | Bob Apodaca | Ken Brett | | 564 | 639 | -75 |
| 1974-09-30 | vs PHI | 160 | W 5-2 | 71-89 | 5 | 5,931 | Jerry Koosman | Larry Christenson | Jerry Koosman | Larry Christenson | | 569 | 641 | -72 |
| 1974-10-01 | vs PHI | 161 | L 1-2 | 71-90 | 5 | 5,341 | Tom Seaver | Jim Lonborg | Jim Lonborg | Tom Seaver | | 570 | 643 | -73 |
| 1974-10-02 | vs PHI | 162 | L 2-3 | 71-91 | 5 | 5,383 | Jon Matlack | Steve Carlton | Gene Garber | Jon Matlack | | 572 | 646 | -74 |