| 1974-04-10 | @ PIT | 1 | W 12-8 | 1-0 | 2 | 40,434 | Steve Renko | Ken Brett | Chuck Taylor | Ramon Hernandez | | 12 | 8 | 4 |
| 1974-04-11 | @ PIT | 2 | W 5-1 | 2-0 | 1 | 5,606 | Steve Rogers | Dock Ellis | Steve Rogers | Dock Ellis | | 17 | 9 | 8 |
| 1974-04-13 | @ CHN | 3 | L 4-7 | 3-1 | 2 | 0 | Ernie McAnally | Ken Frailing | Ken Frailing | Ernie McAnally | | 21 | 16 | 5 |
| 1974-04-13 | @ CHN | 4 | W 13-3 | 3-1 | 2 | 30,066 | Mike Torrez | Bill Bonham | Mike Torrez | Bill Bonham | | 34 | 19 | 15 |
| 1974-04-16 | vs NYN | 5 | W 4-1 | 4-1 | 1 | 18,425 | Steve Renko | Tom Seaver | Steve Renko | Tom Seaver | | 38 | 20 | 18 |
| 1974-04-17 | vs NYN | 6 | W 7-4 | 5-1 | 1 | 10,007 | Steve Rogers | George Stone | Steve Rogers | George Stone | | 45 | 24 | 21 |
| 1974-04-18 | vs NYN | 7 | W 8-5 | 6-1 | 1 | 8,390 | Mike Torrez | Ray Sadecki | Mike Torrez | Ray Sadecki | Chuck Taylor | 53 | 29 | 24 |
| 1974-04-19 | @ SLN | 8 | W 5-4 | 7-1 | 1 | 29,171 | Ernie McAnally | John Curtis | Ernie McAnally | John Curtis | Chuck Taylor | 58 | 33 | 25 |
| 1974-04-20 | @ SLN | 9 | L 4-10 | 7-2 | 1 | 16,400 | Steve Renko | Alan Foster | Alan Foster | Steve Renko | | 62 | 43 | 19 |
| 1974-04-21 | @ SLN | 10 | W 9-5 | 8-2 | 1 | 12,327 | Steve Rogers | Bob Gibson | Steve Rogers | Bob Gibson | | 71 | 48 | 23 |
| 1974-04-23 | @ SFN | 11 | W 8-4 | 9-2 | 1 | 2,627 | Mike Torrez | Tom Bradley | Mike Torrez | Tom Bradley | Tom Walker | 79 | 52 | 27 |
| 1974-04-25 | @ SFN | 12 | L 2-8 | 9-3 | 1 | 1,789 | Ernie McAnally | Mike Caldwell | Mike Caldwell | Ernie McAnally | | 81 | 60 | 21 |
| 1974-04-26 | @ LAN | 13 | L 1-7 | 9-4 | 1 | 30,028 | Steve Renko | Andy Messersmith | Andy Messersmith | Steve Renko | | 82 | 67 | 15 |
| 1974-04-27 | @ LAN | 14 | L 2-5 | 9-5 | 1 | 16,914 | Steve Rogers | Al Downing | Al Downing | Steve Rogers | | 84 | 72 | 12 |
| 1974-04-28 | @ LAN | 15 | L 0-4 | 9-6 | 1 | 27,937 | Mike Torrez | Doug Rau | Doug Rau | Mike Torrez | Mike Marshall | 84 | 76 | 8 |
| 1974-04-30 | @ SDN | 16 | L 1-2 | 9-7 | 2 | 9,390 | Steve Renko | Bill Greif | Bill Greif | Steve Renko | Vicente Romo | 85 | 78 | 7 |
| 1974-05-01 | @ SDN | 17 | L 1-5 | 9-8 | 2 | 12,361 | Ernie McAnally | Dave Freisleben | Dave Freisleben | Ernie McAnally | | 86 | 83 | 3 |
| 1974-05-04 | vs SFN | 18 | W 4-2 | 10-8 | 1 | 12,116 | Steve Rogers | John D'Acquisto | Steve Rogers | John D'Acquisto | | 90 | 85 | 5 |
| 1974-05-05 | vs SFN | 19 | L 0-4 | 10-10 | 3 | 0 | Steve Renko | Mike Caldwell | Mike Caldwell | Steve Renko | | 90 | 89 | 1 |
| 1974-05-05 | vs SFN | 20 | L 1-8 | 10-10 | 3 | 16,101 | Mike Torrez | Tom Bradley | Tom Bradley | Mike Torrez | | 91 | 97 | -6 |
| 1974-05-08 | vs LAN | 21 | L 3-6 | 10-11 | 3 | 16,141 | Ernie McAnally | Andy Messersmith | Andy Messersmith | Ernie McAnally | | 94 | 103 | -9 |
| 1974-05-10 | vs SLN | 22 | W 5-4 | 11-11 | 3 | 7,105 | Steve Rogers | Alan Foster | Steve Rogers | Alan Foster | | 99 | 107 | -8 |
| 1974-05-11 | vs SLN | 23 | W 3-1 | 12-11 | 3 | 11,730 | Steve Renko | Sonny Siebert | Steve Renko | Sonny Siebert | | 102 | 108 | -6 |
| 1974-05-14 | @ PHI | 24 | W 9-2 | 13-11 | 1 | 8,413 | Steve Rogers | Jim Lonborg | Steve Rogers | Jim Lonborg | | 111 | 110 | 1 |
| 1974-05-15 | @ PHI | 25 | W 5-4 | 14-11 | 1 | 10,105 | Steve Renko | Dick Ruthven | Tom Walker | Mac Scarce | | 116 | 114 | 2 |
| 1974-05-16 | @ PHI | 26 | L 3-6 | 14-12 | 1 | 7,311 | Mike Torrez | Steve Carlton | Steve Carlton | Mike Torrez | | 119 | 120 | -1 |
| 1974-05-17 | @ NYN | 27 | L 0-5 | 14-13 | 3 | 23,200 | Balor Moore | Tom Seaver | Tom Seaver | Balor Moore | | 119 | 125 | -6 |
| 1974-05-18 | @ NYN | 28 | L 0-6 | 14-14 | 3 | 48,736 | Steve Rogers | Jon Matlack | Jon Matlack | Steve Rogers | | 119 | 131 | -12 |
| 1974-05-19 | @ NYN | 29 | W 7-4 | 16-14 | 3 | 0 | Steve Renko | Craig Swan | Steve Renko | Craig Swan | Chuck Taylor | 126 | 135 | -9 |
| 1974-05-19 | @ NYN | 30 | W 5-0 | 16-14 | 3 | 40,641 | Ernie McAnally | Jerry Koosman | Ernie McAnally | Jerry Koosman | | 131 | 135 | -4 |
| 1974-05-20 | vs PIT | 31 | W 4-2 | 17-14 | 2 | 12,228 | Mike Torrez | Jim Rooker | Mike Torrez | Jim Rooker | Chuck Taylor | 135 | 137 | -2 |
| 1974-05-21 | vs PIT | 32 | L 4-8 | 17-15 | 2 | 9,231 | Balor Moore | Ken Brett | Ken Brett | Balor Moore | | 139 | 145 | -6 |
| 1974-05-23 | vs PIT | 33 | W 5-4 | 18-15 | 2 | 7,209 | Steve Rogers | Bruce Kison | Steve Rogers | Bruce Kison | Chuck Taylor | 144 | 149 | -5 |
| 1974-05-24 | @ PHI | 34 | W 4-2 | 19-15 | 2 | 14,131 | Ernie McAnally | Jim Lonborg | Ernie McAnally | Jim Lonborg | | 148 | 151 | -3 |
| 1974-05-25 | @ PHI | 35 | L 3-4 | 19-17 | 2 | 0 | Mike Torrez | Dick Ruthven | Eddie Watt | Mike Torrez | | 151 | 155 | -4 |
| 1974-05-25 | @ PHI | 36 | L 2-4 | 19-17 | 2 | 41,350 | Steve Renko | Steve Carlton | Steve Carlton | Steve Renko | | 153 | 159 | -6 |
| 1974-05-26 | @ PHI | 37 | W 5-1 | 20-17 | 2 | 27,324 | Dennis Blair | Ron Schueler | Dennis Blair | Ron Schueler | | 158 | 160 | -2 |
| 1974-05-28 | vs HOU | 38 | L 4-8 | 20-18 | 2 | 10,618 | Steve Rogers | Tom Griffin | Mike Cosgrove | Steve Rogers | | 162 | 168 | -6 |
| 1974-05-29 | vs HOU | 39 | L 3-5 | 20-19 | 2 | 13,119 | Ernie McAnally | Claude Osteen | Ken Forsch | Tom Walker | | 165 | 173 | -8 |
| 1974-05-30 | vs HOU | 40 | L 3-4 | 20-20 | 3 | 6,593 | Mike Torrez | Larry Dierker | Jerry Johnson | Chuck Taylor | Fred Scherman | 168 | 177 | -9 |
| 1974-06-01 | vs ATL | 41 | W 7-6 | 21-20 | 3 | 22,123 | Dennis Blair | Phil Niekro | Chuck Taylor | Lew Krausse | | 175 | 183 | -8 |
| 1974-06-02 | vs ATL | 42 | L 0-9 | 21-21 | 3 | 24,432 | Steve Rogers | Buzz Capra | Buzz Capra | Steve Rogers | | 175 | 192 | -17 |
| 1974-06-04 | @ HOU | 43 | W 5-0 | 22-21 | 3 | 11,017 | Ernie McAnally | Tom Griffin | Ernie McAnally | Tom Griffin | | 180 | 192 | -12 |
| 1974-06-05 | @ HOU | 44 | W 8-3 | 23-21 | 3 | 10,472 | Mike Torrez | Claude Osteen | Mike Torrez | Claude Osteen | | 188 | 195 | -7 |
| 1974-06-06 | @ HOU | 45 | L 0-4 | 23-22 | 3 | 8,029 | Steve Renko | Larry Dierker | Larry Dierker | Steve Renko | | 188 | 199 | -11 |
| 1974-06-07 | @ ATL | 46 | L 0-5 | 23-23 | 3 | 6,518 | Dennis Blair | Buzz Capra | Buzz Capra | Dennis Blair | | 188 | 204 | -16 |
| 1974-06-08 | @ ATL | 47 | L 3-5 | 23-24 | 3 | 13,705 | Steve Rogers | Carl Morton | Carl Morton | Steve Rogers | Tom House | 191 | 209 | -18 |
| 1974-06-09 | @ ATL | 48 | L 2-3 | 24-25 | 3 | 0 | Ernie McAnally | Phil Niekro | Phil Niekro | Ernie McAnally | Danny Frisella | 193 | 212 | -19 |
| 1974-06-09 | @ ATL | 49 | W 7-3 | 24-25 | 3 | 20,138 | Mike Torrez | Roric Harrison | Mike Torrez | Roric Harrison | | 200 | 215 | -15 |
| 1974-06-10 | vs CIN | 50 | W 3-1 | 25-25 | 3 | 14,192 | Steve Renko | Jack Billingham | Steve Renko | Jack Billingham | Chuck Taylor | 203 | 216 | -13 |
| 1974-06-11 | vs CIN | 51 | W 16-6 | 26-25 | 3 | 12,450 | Dennis Blair | Roger Nelson | Tom Walker | Tom Hall | | 219 | 222 | -3 |
| 1974-06-12 | vs CIN | 52 | L 1-3 | 26-26 | 3 | 11,531 | Steve Rogers | Clay Kirby | Clay Kirby | Steve Rogers | | 220 | 225 | -5 |
| 1974-06-14 | vs SDN | 53 | L 4-5 | 26-27 | 3 | 17,124 | Ernie McAnally | Dan Spillner | Larry Hardy | Ernie McAnally | Randy Jones | 224 | 230 | -6 |
| 1974-06-15 | vs SDN | 54 | W 6-4 | 27-27 | 3 | 16,224 | Mike Torrez | Bill Greif | John Montague | Bill Greif | Tom Walker | 230 | 234 | -4 |
| 1974-06-16 | vs SDN | 55 | W 9-8 | 28-27 | 3 | 13,534 | Steve Renko | Lowell Palmer | Don DeMola | Vicente Romo | | 239 | 242 | -3 |
| 1974-06-17 | @ CIN | 56 | L 3-12 | 28-28 | 3 | 18,001 | Steve Rogers | Fred Norman | Fred Norman | Steve Rogers | | 242 | 254 | -12 |
| 1974-06-18 | @ CIN | 57 | W 2-1 | 29-28 | 3 | 21,656 | Ernie McAnally | Clay Kirby | Ernie McAnally | Clay Kirby | | 244 | 255 | -11 |
| 1974-06-19 | @ CIN | 58 | W 4-2 | 30-28 | 2 | 22,344 | Mike Torrez | Don Gullett | Mike Torrez | Don Gullett | John Montague | 248 | 257 | -9 |
| 1974-06-21 | @ SLN | 59 | L 1-5 | 30-29 | 3 | 17,949 | Steve Renko | Sonny Siebert | Sonny Siebert | Steve Renko | | 249 | 262 | -13 |
| 1974-06-22 | @ SLN | 60 | L 3-4 | 30-30 | 3 | 42,640 | Steve Rogers | Lynn McGlothen | Lynn McGlothen | Steve Rogers | Mike Garman | 252 | 266 | -14 |
| 1974-06-23 | @ SLN | 61 | W 4-2 | 31-30 | 3 | 21,528 | Ernie McAnally | John Curtis | Chuck Taylor | Al Hrabosky | | 256 | 268 | -12 |
| 1974-06-24 | vs PHI | 62 | L 2-8 | 31-31 | 3 | 15,083 | Mike Torrez | Jim Lonborg | Jim Lonborg | Mike Torrez | | 258 | 276 | -18 |
| 1974-06-25 | vs PHI | 63 | W 5-0 | 32-31 | 3 | 18,122 | Steve Renko | Dick Ruthven | Steve Renko | Dick Ruthven | | 263 | 276 | -13 |
| 1974-06-26 | vs PHI | 64 | W 2-0 | 33-31 | 3 | 16,108 | Steve Rogers | Steve Carlton | Steve Rogers | Steve Carlton | | 265 | 276 | -11 |
| 1974-06-27 | vs CHN | 65 | L 4-5 | 33-32 | 3 | 12,345 | Ernie McAnally | Bill Bonham | Bill Bonham | Ernie McAnally | Oscar Zamora | 269 | 281 | -12 |
| 1974-06-28 | vs CHN | 66 | L 7-8 | 34-33 | 3 | 0 | Mike Torrez | Jim Todd | Ray Burris | Ernie McAnally | Bill Bonham | 276 | 289 | -13 |
| 1974-06-28 | vs CHN | 67 | W 15-0 | 34-33 | 3 | 20,098 | Dennis Blair | Ken Frailing | Dennis Blair | Ken Frailing | | 291 | 289 | 2 |
| 1974-06-29 | vs CHN | 68 | L 1-2 | 34-34 | 3 | 14,283 | Steve Renko | Rick Reuschel | Rick Reuschel | Steve Renko | | 292 | 291 | 1 |
| 1974-06-30 | vs CHN | 69 | W 10-2 | 35-34 | 2 | 13,406 | Steve Rogers | Steve Stone | Steve Rogers | Steve Stone | | 302 | 293 | 9 |
| 1974-07-01 | vs CHN | 70 | W 10-4 | 36-34 | 2 | 17,143 | Ernie McAnally | Bill Bonham | Ernie McAnally | Bill Bonham | | 312 | 297 | 15 |
| 1974-07-02 | @ PIT | 71 | L 2-4 | 36-35 | 2 | 13,138 | Mike Torrez | Jim Rooker | Jim Rooker | John Montague | | 314 | 301 | 13 |
| 1974-07-03 | @ PIT | 72 | L 1-2 | 36-36 | 2 | 11,123 | Don DeMola | Jerry Reuss | Jerry Reuss | John Montague | | 315 | 303 | 12 |
| 1974-07-04 | @ PIT | 73 | W 2-1 | 37-37 | 2 | 0 | Steve Rogers | Ken Brett | Steve Rogers | Ken Brett | | 317 | 304 | 13 |
| 1974-07-04 | @ PIT | 74 | L 2-3 | 37-37 | 2 | 22,456 | Dennis Blair | Dave Giusti | Bruce Kison | Dennis Blair | | 319 | 307 | 12 |
| 1974-07-05 | vs LAN | 75 | W 11-6 | 38-38 | 2 | 0 | Steve Renko | Al Downing | Steve Renko | Al Downing | Chuck Taylor | 330 | 313 | 17 |
| 1974-07-05 | vs LAN | 76 | L 0-7 | 38-38 | 2 | 23,167 | Ernie McAnally | Geoff Zahn | Geoff Zahn | Ernie McAnally | | 330 | 320 | 10 |
| 1974-07-06 | vs LAN | 77 | W 6-1 | 39-38 | 2 | 22,127 | Mike Torrez | Don Sutton | Mike Torrez | Don Sutton | | 336 | 321 | 15 |
| 1974-07-07 | vs LAN | 78 | L 1-4 | 39-40 | 3 | 0 | John Montague | Tommy John | Tommy John | John Montague | Mike Marshall | 337 | 325 | 12 |
| 1974-07-07 | vs LAN | 79 | L 3-5 | 39-40 | 3 | 30,416 | Don Carrithers | Doug Rau | Doug Rau | Don Carrithers | Mike Marshall | 340 | 330 | 10 |
| 1974-07-08 | vs SFN | 80 | L 4-5 | 39-41 | 3 | 13,523 | Steve Rogers | Ed Halicki | Randy Moffitt | Steve Rogers | | 344 | 335 | 9 |
| 1974-07-09 | vs SFN | 81 | W 5-4 | 40-41 | 3 | 10,037 | Dennis Blair | Tom Bradley | Dennis Blair | Tom Bradley | John Montague | 349 | 339 | 10 |
| 1974-07-10 | vs SFN | 82 | L 2-4 | 40-42 | 3 | 15,112 | Steve Renko | Jim Barr | Jim Barr | Steve Renko | | 351 | 343 | 8 |
| 1974-07-12 | @ SDN | 83 | L 0-1 | 40-43 | 3 | 24,511 | Ernie McAnally | Randy Jones | Randy Jones | Ernie McAnally | | 351 | 344 | 7 |
| 1974-07-13 | @ SDN | 84 | L 1-5 | 40-44 | 3 | 10,649 | Steve Rogers | Dave Freisleben | Dave Freisleben | Steve Rogers | | 352 | 349 | 3 |
| 1974-07-14 | @ SDN | 85 | W 6-1 | 42-44 | 3 | 0 | Mike Torrez | Dan Spillner | Mike Torrez | Dan Spillner | | 358 | 350 | 8 |
| 1974-07-14 | @ SDN | 86 | W 6-2 | 42-44 | 3 | 13,107 | Dennis Blair | Lowell Palmer | Dennis Blair | Lowell Palmer | | 364 | 352 | 12 |
| 1974-07-16 | @ LAN | 87 | W 8-7 | 43-44 | 2 | 35,544 | Steve Renko | Don Sutton | John Montague | Charlie Hough | | 372 | 359 | 13 |
| 1974-07-17 | @ LAN | 88 | W 5-4 | 44-44 | 2 | 25,176 | Steve Rogers | Tommy John | Don Carrithers | Geoff Zahn | | 377 | 363 | 14 |
| 1974-07-18 | @ LAN | 89 | L 5-7 | 44-45 | 2 | 24,491 | Ernie McAnally | Andy Messersmith | Andy Messersmith | Ernie McAnally | | 382 | 370 | 12 |
| 1974-07-19 | @ SFN | 90 | L 2-6 | 44-46 | 2 | 3,121 | Mike Torrez | Mike Caldwell | Mike Caldwell | Mike Torrez | Randy Moffitt | 384 | 376 | 8 |
| 1974-07-20 | @ SFN | 91 | W 3-2 | 45-46 | 2 | 5,141 | Dennis Blair | Ed Halicki | Dennis Blair | Ed Halicki | | 387 | 378 | 9 |
| 1974-07-21 | @ SFN | 92 | L 0-4 | 45-48 | 3 | 0 | Steve Renko | Jim Barr | Jim Barr | Steve Renko | | 387 | 382 | 5 |
| 1974-07-21 | @ SFN | 93 | L 0-2 | 45-48 | 3 | 8,007 | Steve Rogers | John D'Acquisto | John D'Acquisto | Steve Rogers | Elias Sosa | 387 | 384 | 3 |
| 1974-07-25 | vs PIT | 94 | W 10-5 | 46-49 | 3 | 0 | Steve Renko | Jim Rooker | Steve Renko | Jim Rooker | | 397 | 389 | 8 |
| 1974-07-25 | vs PIT | 95 | L 2-3 | 46-49 | 3 | 27,283 | Steve Rogers | Jerry Reuss | Jerry Reuss | Steve Rogers | Dave Giusti | 399 | 392 | 7 |
| 1974-07-26 | vs PIT | 96 | L 0-3 | 46-50 | 4 | 22,278 | Dennis Blair | Dock Ellis | Dock Ellis | Dennis Blair | Ramon Hernandez | 399 | 395 | 4 |
| 1974-07-27 | @ NYN | 97 | L 5-8 | 46-51 | 4 | 32,565 | Mike Torrez | Bob Apodaca | Bob Apodaca | Mike Torrez | | 404 | 403 | 1 |
| 1974-07-28 | @ NYN | 98 | L 1-4 | 46-52 | 4 | 26,306 | Ernie McAnally | Harry Parker | Tug McGraw | Ernie McAnally | | 405 | 407 | -2 |
| 1974-07-29 | @ NYN | 99 | L 3-4 | 46-53 | 4 | 17,343 | Steve Rogers | George Stone | Jack Aker | Steve Rogers | | 408 | 411 | -3 |
| 1974-07-30 | @ CHN | 100 | W 4-3 | 47-53 | 4 | 12,000 | Steve Renko | Rick Reuschel | John Montague | Rick Reuschel | | 412 | 414 | -2 |
| 1974-07-31 | @ CHN | 101 | W 7-4 | 49-53 | 4 | 0 | Mike Torrez | Bill Bonham | Chuck Taylor | Bill Bonham | | 419 | 418 | 1 |
| 1974-07-31 | @ CHN | 102 | W 4-0 | 49-53 | 4 | 19,329 | Dennis Blair | Herb Hutson | Dennis Blair | Herb Hutson | | 423 | 418 | 5 |
| 1974-08-01 | @ PHI | 103 | L 4-6 | 49-54 | 4 | 0 | Ernie McAnally | Wayne Twitchell | Wayne Twitchell | Ernie McAnally | | 427 | 424 | 3 |
| 1974-08-02 | @ PHI | 104 | W 3-2 | 50-54 | 4 | 21,068 | Steve Rogers | Steve Carlton | Steve Rogers | Eddie Watt | Chuck Taylor | 430 | 426 | 4 |
| 1974-08-03 | vs NYN | 105 | L 0-3 | 50-55 | 4 | 21,089 | Steve Renko | Jon Matlack | Jon Matlack | Steve Renko | | 430 | 429 | 1 |
| 1974-08-05 | vs NYN | 106 | L 4-10 | 50-56 | 4 | 20,118 | Dennis Blair | Tom Seaver | Tug McGraw | Dennis Blair | | 434 | 439 | -5 |
| 1974-08-06 | vs SLN | 107 | L 4-5 | 50-58 | 4 | 0 | Mike Torrez | Lynn McGlothen | Lynn McGlothen | Mike Torrez | Al Hrabosky | 438 | 444 | -6 |
| 1974-08-06 | vs SLN | 108 | L 4-9 | 50-58 | 4 | 21,352 | Steve Rogers | Ray Bare | Rich Folkers | Steve Rogers | | 442 | 453 | -11 |
| 1974-08-07 | vs SLN | 109 | W 7-5 | 51-58 | 4 | 19,023 | Steve Renko | Bob Forsch | Steve Renko | Bob Forsch | | 449 | 458 | -9 |
| 1974-08-08 | vs SLN | 110 | W 3-2 | 52-58 | 4 | 17,205 | Tom Walker | Sonny Siebert | Don Carrithers | John Curtis | | 452 | 460 | -8 |
| 1974-08-09 | @ HOU | 111 | W 4-3 | 53-58 | 4 | 12,832 | Dennis Blair | Don Wilson | Dennis Blair | Don Wilson | Don Carrithers | 456 | 463 | -7 |
| 1974-08-10 | @ HOU | 112 | W 2-1 | 54-58 | 4 | 17,107 | Steve Rogers | Tom Griffin | Steve Rogers | Tom Griffin | | 458 | 464 | -6 |
| 1974-08-11 | @ HOU | 113 | W 5-2 | 55-58 | 4 | 15,180 | Steve Renko | Larry Dierker | Steve Renko | Larry Dierker | Chuck Taylor | 463 | 466 | -3 |
| 1974-08-13 | @ ATL | 114 | L 3-4 | 55-59 | 4 | 7,950 | Tom Walker | Ron Reed | Ron Reed | Tom Walker | Phil Niekro | 466 | 470 | -4 |
| 1974-08-14 | @ ATL | 115 | L 1-6 | 55-60 | 4 | 6,009 | Dennis Blair | Carl Morton | Carl Morton | Dennis Blair | | 467 | 476 | -9 |
| 1974-08-16 | vs HOU | 116 | L 3-8 | 55-61 | 4 | 18,129 | Steve Rogers | Tom Griffin | Tom Griffin | Steve Rogers | Mike Cosgrove | 470 | 484 | -14 |
| 1974-08-17 | vs HOU | 117 | W 3-2 | 56-61 | 4 | 15,175 | Steve Renko | Larry Dierker | Chuck Taylor | Ken Forsch | | 473 | 486 | -13 |
| 1974-08-18 | vs HOU | 118 | L 0-3 | 56-62 | 4 | 19,098 | Tom Walker | Dave Roberts | Dave Roberts | Tom Walker | | 473 | 489 | -16 |
| 1974-08-19 | vs SDN | 119 | W 7-4 | 57-62 | 4 | 11,146 | Dennis Blair | Randy Jones | Don Carrithers | Randy Jones | Chuck Taylor | 480 | 493 | -13 |
| 1974-08-20 | vs SDN | 120 | L 0-3 | 57-63 | 4 | 12,713 | Steve Rogers | Dave Freisleben | Dave Freisleben | Steve Rogers | | 480 | 496 | -16 |
| 1974-08-21 | vs SDN | 121 | W 8-7 | 58-63 | 4 | 18,037 | Steve Renko | Dan Spillner | Chuck Taylor | Larry Hardy | | 488 | 503 | -15 |
| 1974-08-23 | vs CIN | 122 | L 7-10 | 58-64 | 4 | 20,468 | Tom Walker | Jack Billingham | Clay Carroll | Tom Walker | | 495 | 513 | -18 |
| 1974-08-24 | vs CIN | 123 | L 4-6 | 58-65 | 4 | 18,466 | Steve Rogers | Don Gullett | Don Gullett | Steve Rogers | | 499 | 519 | -20 |
| 1974-08-25 | vs CIN | 124 | L 1-3 | 58-66 | 4 | 21,161 | Dennis Blair | Clay Kirby | Clay Kirby | Dennis Blair | | 500 | 522 | -22 |
| 1974-08-26 | vs ATL | 125 | L 2-3 | 58-67 | 4 | 14,139 | Steve Renko | Buzz Capra | Buzz Capra | Steve Renko | Max Leon | 502 | 525 | -23 |
| 1974-08-27 | vs ATL | 126 | W 6-1 | 59-67 | 4 | 12,183 | Mike Torrez | Ron Reed | Mike Torrez | Ron Reed | | 508 | 526 | -18 |
| 1974-08-28 | vs ATL | 127 | L 2-4 | 59-68 | 4 | 14,121 | Tom Walker | Carl Morton | Carl Morton | John Montague | | 510 | 530 | -20 |
| 1974-08-29 | vs ATL | 128 | L 2-7 | 59-69 | 4 | 5,187 | Steve Rogers | Phil Niekro | Phil Niekro | Steve Rogers | | 512 | 537 | -25 |
| 1974-08-30 | @ CIN | 129 | W 11-3 | 60-69 | 4 | 26,714 | Dennis Blair | Clay Kirby | Dennis Blair | Clay Kirby | | 523 | 540 | -17 |
| 1974-08-31 | @ CIN | 130 | L 3-10 | 60-70 | 4 | 34,101 | Steve Renko | Jack Billingham | Jack Billingham | Steve Renko | | 526 | 550 | -24 |
| 1974-09-01 | @ CIN | 131 | W 2-1 | 61-70 | 4 | 30,037 | Mike Torrez | Don Gullett | Mike Torrez | Don Gullett | | 528 | 551 | -23 |
| 1974-09-03 | @ SLN | 132 | L 1-5 | 61-72 | 5 | 0 | Tom Walker | Lynn McGlothen | Lynn McGlothen | Tom Walker | | 529 | 556 | -27 |
| 1974-09-03 | @ SLN | 133 | L 4-8 | 61-72 | 5 | 15,366 | Steve Rogers | John Curtis | Mike Garman | Steve Rogers | | 533 | 564 | -31 |
| 1974-09-04 | @ SLN | 134 | L 4-5 | 61-73 | 5 | 13,288 | Dennis Blair | Alan Foster | Rich Folkers | Chuck Taylor | Al Hrabosky | 537 | 569 | -32 |
| 1974-09-06 | @ PIT | 135 | L 1-2 | 61-74 | 5 | 15,386 | Steve Renko | Dock Ellis | Dock Ellis | Steve Renko | | 538 | 571 | -33 |
| 1974-09-07 | @ PIT | 136 | L 5-6 | 61-75 | 5 | 17,576 | Mike Torrez | Jerry Reuss | Ramon Hernandez | Dale Murray | | 543 | 577 | -34 |
| 1974-09-08 | @ PIT | 137 | L 2-8 | 61-76 | 5 | 18,870 | Steve Rogers | Jim Rooker | Jim Rooker | Steve Rogers | | 545 | 585 | -40 |
| 1974-09-09 | @ NYN | 138 | L 1-7 | 61-77 | 5 | 9,960 | Dennis Blair | Ray Sadecki | Ray Sadecki | Dennis Blair | | 546 | 592 | -46 |
| 1974-09-10 | @ NYN | 139 | W 6-4 | 62-77 | 5 | 9,951 | Ernie McAnally | Tug McGraw | Don Carrithers | Tug McGraw | Dale Murray | 552 | 596 | -44 |
| 1974-09-11 | vs CHN | 140 | W 6-1 | 64-77 | 5 | 0 | Steve Renko | Bill Bonham | Steve Renko | Bill Bonham | Dale Murray | 558 | 597 | -39 |
| 1974-09-11 | vs CHN | 141 | W 13-4 | 64-77 | 5 | 7,462 | Tom Walker | Ray Burris | Tom Walker | Ray Burris | Chuck Taylor | 571 | 601 | -30 |
| 1974-09-12 | vs CHN | 142 | W 2-1 | 65-77 | 5 | 5,163 | Mike Torrez | Tom Dettore | Mike Torrez | Tom Dettore | Dale Murray | 573 | 602 | -29 |
| 1974-09-13 | vs PIT | 143 | W 3-2 | 66-77 | 4 | 9,283 | Steve Rogers | Jim Rooker | Steve Rogers | Jim Rooker | | 576 | 604 | -28 |
| 1974-09-14 | vs PIT | 144 | W 17-2 | 67-77 | 4 | 15,566 | Dennis Blair | Larry Demery | Dennis Blair | Larry Demery | | 593 | 606 | -13 |
| 1974-09-15 | vs PIT | 145 | W 5-4 | 68-77 | 4 | 15,438 | Steve Renko | Ken Brett | Steve Renko | Ken Brett | Dale Murray | 598 | 610 | -12 |
| 1974-09-16 | vs NYN | 146 | W 3-2 | 69-78 | 4 | 0 | Mike Torrez | Jerry Koosman | Mike Torrez | Jerry Koosman | John Montague | 601 | 612 | -11 |
| 1974-09-16 | vs NYN | 147 | L 2-3 | 69-78 | 4 | 9,166 | Don Carrithers | Randy Sterling | Randy Sterling | Don Carrithers | Tug McGraw | 603 | 615 | -12 |
| 1974-09-18 | vs NYN | 148 | W 3-2 | 71-78 | 4 | 0 | Steve Rogers | Jon Matlack | Steve Rogers | Jon Matlack | Dale Murray | 606 | 617 | -11 |
| 1974-09-18 | vs NYN | 149 | W 4-0 | 71-78 | 4 | 9,288 | Dennis Blair | Tom Seaver | Dennis Blair | Tom Seaver | Dale Murray | 610 | 617 | -7 |
| 1974-09-20 | vs PHI | 150 | L 2-10 | 71-79 | 4 | 8,166 | Steve Renko | Steve Carlton | Steve Carlton | Steve Renko | | 612 | 627 | -15 |
| 1974-09-22 | vs PHI | 151 | L 2-3 | 72-80 | 4 | 0 | Steve Rogers | Jim Lonborg | Jim Lonborg | Steve Rogers | Gene Garber | 614 | 630 | -16 |
| 1974-09-22 | vs PHI | 152 | W 8-5 | 72-80 | 4 | 11,183 | Mike Torrez | Dick Ruthven | Mike Torrez | Dick Ruthven | Dale Murray | 622 | 635 | -13 |
| 1974-09-24 | @ CHN | 153 | L 4-6 | 73-81 | 4 | 0 | Steve Renko | Burt Hooton | Burt Hooton | Steve Renko | Oscar Zamora | 626 | 641 | -15 |
| 1974-09-24 | @ CHN | 154 | W 11-2 | 73-81 | 4 | 1,751 | Don Carrithers | Ray Burris | Don Carrithers | Ray Burris | Dale Murray | 637 | 643 | -6 |
| 1974-09-25 | @ CHN | 155 | W 7-1 | 75-81 | 4 | 0 | Tom Walker | Bill Bonham | Tom Walker | Bill Bonham | | 644 | 644 | 0 |
| 1974-09-25 | @ CHN | 156 | W 3-2 | 75-81 | 4 | 2,537 | Steve Rogers | Jim Kremmel | Steve Rogers | Jim Kremmel | Dale Murray | 647 | 646 | 1 |
| 1974-09-27 | vs PHI | 157 | W 2-0 | 76-81 | 4 | 8,179 | Mike Torrez | Jim Lonborg | Mike Torrez | Jim Lonborg | | 649 | 646 | 3 |
| 1974-09-28 | vs PHI | 158 | W 3-1 | 77-81 | 4 | 6,499 | Steve Renko | Steve Carlton | Steve Renko | Steve Carlton | | 652 | 647 | 5 |
| 1974-09-29 | vs PHI | 159 | W 6-3 | 78-81 | 3 | 23,326 | Dennis Blair | Ron Schueler | Dennis Blair | Ron Schueler | Dale Murray | 658 | 650 | 8 |
| 1974-09-30 | vs SLN | 160 | L 1-5 | 78-82 | 3 | 5,337 | Steve Rogers | Bob Forsch | Bob Forsch | Steve Rogers | | 659 | 655 | 4 |
| 1974-10-01 | vs SLN | 161 | W 3-2 | 79-82 | 3 | 5,112 | Mike Torrez | Bob Gibson | Dale Murray | Bob Gibson | | 662 | 657 | 5 |