| 1974-04-05 | vs MIN | 1 | L 4-6 | 0-1 | 5 | 31,781 | Paul Splittorff | Bert Blyleven | Bill Campbell | Lindy McDaniel | | 4 | 6 | -2 |
| 1974-04-06 | vs MIN | 2 | W 23-6 | 1-1 | 2 | 11,228 | Steve Busby | Bill Hands | Steve Busby | Bill Hands | | 27 | 12 | 15 |
| 1974-04-09 | vs OAK | 3 | L 4-6 | 1-2 | 5 | 17,792 | Paul Splittorff | Catfish Hunter | Darold Knowles | Gene Garber | Paul Lindblad | 31 | 18 | 13 |
| 1974-04-10 | vs OAK | 4 | W 4-1 | 2-2 | 4 | 14,679 | Steve Busby | Ken Holtzman | Steve Busby | Ken Holtzman | | 35 | 19 | 16 |
| 1974-04-13 | @ MIN | 5 | W 6-5 | 3-2 | 3 | 3,381 | Marty Pattin | Dick Woodson | Bruce Dal Canton | Tom Burgmeier | | 41 | 24 | 17 |
| 1974-04-14 | @ MIN | 6 | L 0-8 | 3-3 | 3 | 2,778 | Paul Splittorff | Bert Blyleven | Bert Blyleven | Paul Splittorff | | 41 | 32 | 9 |
| 1974-04-16 | @ TEX | 7 | L 2-3 | 3-4 | 5 | 12,066 | Steve Busby | David Clyde | Steve Foucault | Steve Busby | | 43 | 35 | 8 |
| 1974-04-17 | @ TEX | 8 | L 2-4 | 3-5 | 5 | 9,799 | Nelson Briles | Jim Bibby | Jim Bibby | Gene Garber | | 45 | 39 | 6 |
| 1974-04-19 | @ CHA | 9 | L 4-5 | 3-6 | 5 | 9,317 | Marty Pattin | Jim Kaat | Jim Kaat | Bruce Dal Canton | Terry Forster | 49 | 44 | 5 |
| 1974-04-20 | @ CHA | 10 | W 7-3 | 4-6 | 5 | 30,472 | Paul Splittorff | Wilbur Wood | Paul Splittorff | Wilbur Wood | | 56 | 47 | 9 |
| 1974-04-21 | @ CHA | 11 | L 7-11 | 4-7 | 5 | 7,890 | Steve Busby | Stan Bahnsen | Terry Forster | Steve Busby | | 63 | 58 | 5 |
| 1974-04-22 | @ BOS | 12 | L 1-4 | 4-8 | 6 | 11,927 | Nelson Briles | Rick Wise | Rick Wise | Nelson Briles | Diego Segui | 64 | 62 | 2 |
| 1974-04-23 | @ BOS | 13 | W 5-2 | 5-8 | 5 | 5,388 | Al Fitzmorris | Dick Drago | Al Fitzmorris | Dick Drago | | 69 | 64 | 5 |
| 1974-04-24 | @ NYA | 14 | L 3-4 | 5-9 | 6 | 5,593 | Marty Pattin | Doc Medich | Doc Medich | Marty Pattin | Sparky Lyle | 72 | 68 | 4 |
| 1974-04-25 | @ NYA | 15 | W 6-1 | 6-9 | 6 | 5,646 | Paul Splittorff | Steve Kline | Paul Splittorff | Steve Kline | | 78 | 69 | 9 |
| 1974-04-26 | vs BOS | 16 | W 4-2 | 7-9 | 6 | 13,537 | Steve Busby | Bill Lee | Steve Busby | Bill Lee | | 82 | 71 | 11 |
| 1974-04-27 | vs BOS | 17 | W 10-3 | 8-9 | 4 | 11,841 | Al Fitzmorris | Juan Marichal | Al Fitzmorris | Juan Marichal | | 92 | 74 | 18 |
| 1974-04-28 | vs BOS | 18 | L 4-5 | 8-10 | 4 | 13,306 | Marty Pattin | Roger Moret | Dick Drago | Doug Bird | | 96 | 79 | 17 |
| 1974-04-30 | vs DET | 19 | L 2-7 | 8-11 | 6 | 9,310 | Paul Splittorff | Mickey Lolich | Mickey Lolich | Paul Splittorff | | 98 | 86 | 12 |
| 1974-05-01 | vs DET | 20 | L 1-2 | 8-12 | 6 | 9,146 | Steve Busby | Lerrin LaGrow | Lerrin LaGrow | Steve Busby | | 99 | 88 | 11 |
| 1974-05-02 | vs DET | 21 | L 7-9 | 8-13 | 6 | 9,162 | Al Fitzmorris | Joe Coleman | Joe Coleman | Al Fitzmorris | | 106 | 97 | 9 |
| 1974-05-03 | vs NYA | 22 | L 4-5 | 8-14 | 6 | 13,246 | Marty Pattin | Doc Medich | Doc Medich | Steve Mingori | Sparky Lyle | 110 | 102 | 8 |
| 1974-05-04 | vs NYA | 23 | W 5-1 | 9-14 | 6 | 18,978 | Paul Splittorff | Mel Stottlemyre | Paul Splittorff | Mel Stottlemyre | | 115 | 103 | 12 |
| 1974-05-05 | vs NYA | 24 | W 8-2 | 10-14 | 6 | 14,410 | Steve Busby | Pat Dobson | Steve Busby | Pat Dobson | | 123 | 105 | 18 |
| 1974-05-08 | @ TEX | 25 | W 4-2 | 11-14 | 6 | 10,466 | Al Fitzmorris | Fergie Jenkins | Al Fitzmorris | Fergie Jenkins | | 127 | 107 | 20 |
| 1974-05-09 | @ TEX | 26 | W 6-1 | 12-14 | 6 | 6,456 | Marty Pattin | Jim Bibby | Marty Pattin | Jim Bibby | | 133 | 108 | 25 |
| 1974-05-10 | @ CAL | 27 | L 1-2 | 12-15 | 6 | 12,534 | Paul Splittorff | Nolan Ryan | Nolan Ryan | Paul Splittorff | | 134 | 110 | 24 |
| 1974-05-11 | @ CAL | 28 | W 10-2 | 13-15 | 6 | 15,011 | Steve Busby | Bill Stoneman | Steve Busby | Bill Stoneman | | 144 | 112 | 32 |
| 1974-05-12 | @ CAL | 29 | W 3-2 | 15-15 | 3 | 0 | Al Fitzmorris | Frank Tanana | Doug Bird | Frank Tanana | | 147 | 114 | 33 |
| 1974-05-12 | @ CAL | 30 | W 5-2 | 15-15 | 3 | 13,162 | Bruce Dal Canton | Dick Lange | Joe Hoerner | Dick Selma | | 152 | 116 | 36 |
| 1974-05-13 | @ OAK | 31 | L 2-11 | 15-16 | 5 | 3,615 | Marty Pattin | Vida Blue | Vida Blue | Marty Pattin | | 154 | 127 | 27 |
| 1974-05-14 | @ OAK | 32 | W 4-2 | 16-17 | 4 | 0 | Paul Splittorff | Catfish Hunter | Paul Splittorff | Catfish Hunter | Doug Bird | 158 | 129 | 29 |
| 1974-05-14 | @ OAK | 33 | L 1-2 | 16-17 | 4 | 7,271 | Lindy McDaniel | Glenn Abbott | Rollie Fingers | Lindy McDaniel | | 159 | 131 | 28 |
| 1974-05-16 | vs TEX | 34 | W 5-3 | 17-17 | 3 | 11,141 | Steve Busby | Fergie Jenkins | Steve Busby | Fergie Jenkins | Doug Bird | 164 | 134 | 30 |
| 1974-05-17 | vs TEX | 35 | W 6-4 | 18-17 | 3 | 13,916 | Al Fitzmorris | Jim Bibby | Bruce Dal Canton | Jim Bibby | Doug Bird | 170 | 138 | 32 |
| 1974-05-18 | vs TEX | 36 | L 3-7 | 18-18 | 3 | 14,944 | Marty Pattin | Steve Hargan | Steve Hargan | Marty Pattin | | 173 | 145 | 28 |
| 1974-05-19 | vs TEX | 37 | L 3-8 | 18-19 | 5 | 22,081 | Paul Splittorff | David Clyde | Jackie Brown | Paul Splittorff | | 176 | 153 | 23 |
| 1974-05-21 | vs CAL | 38 | W 4-2 | 19-19 | 3 | 9,814 | Steve Busby | Frank Tanana | Steve Busby | Frank Tanana | Joe Hoerner | 180 | 155 | 25 |
| 1974-05-22 | vs CAL | 39 | L 1-6 | 19-20 | 4 | 10,221 | Al Fitzmorris | Bill Singer | Bill Singer | Al Fitzmorris | | 181 | 161 | 20 |
| 1974-05-23 | vs CAL | 40 | L 1-3 | 19-21 | 4 | 15,600 | Bruce Dal Canton | Nolan Ryan | Nolan Ryan | Bruce Dal Canton | | 182 | 164 | 18 |
| 1974-05-24 | vs CHA | 41 | W 4-2 | 20-21 | 3 | 12,239 | Paul Splittorff | Stan Bahnsen | Paul Splittorff | Stan Bahnsen | | 186 | 166 | 20 |
| 1974-05-25 | vs CHA | 42 | W 4-3 | 21-21 | 3 | 13,034 | Steve Busby | Wilbur Wood | Doug Bird | Wilbur Wood | | 190 | 169 | 21 |
| 1974-05-26 | vs CHA | 43 | W 4-1 | 22-21 | 2 | 14,639 | Al Fitzmorris | Jim Kaat | Al Fitzmorris | Jim Kaat | | 194 | 170 | 24 |
| 1974-05-27 | vs BAL | 44 | W 9-1 | 23-21 | 2 | 16,193 | Bruce Dal Canton | Jim Palmer | Bruce Dal Canton | Jim Palmer | | 203 | 171 | 32 |
| 1974-05-28 | vs BAL | 45 | W 9-5 | 24-21 | 2 | 10,995 | Paul Splittorff | Dave McNally | Doug Bird | Bob Reynolds | | 212 | 176 | 36 |
| 1974-05-29 | vs BAL | 46 | L 3-10 | 24-22 | 2 | 14,727 | Steve Busby | Mike Cuellar | Mike Cuellar | Steve Busby | | 215 | 186 | 29 |
| 1974-05-31 | @ CLE | 47 | W 4-2 | 25-22 | 2 | 15,827 | Al Fitzmorris | Steve Kline | Steve Mingori | Steve Kline | | 219 | 188 | 31 |
| 1974-06-01 | @ CLE | 48 | L 2-5 | 25-23 | 2 | 4,205 | Bruce Dal Canton | Jim Perry | Jim Perry | Bruce Dal Canton | | 221 | 193 | 28 |
| 1974-06-02 | @ CLE | 49 | L 2-5 | 25-24 | 2 | 23,817 | Paul Splittorff | Gaylord Perry | Gaylord Perry | Paul Splittorff | | 223 | 198 | 25 |
| 1974-06-03 | @ BAL | 50 | L 3-4 | 25-25 | 2 | 6,645 | Steve Busby | Doyle Alexander | Doyle Alexander | Steve Busby | Grant Jackson | 226 | 202 | 24 |
| 1974-06-04 | @ BAL | 51 | W 8-0 | 26-25 | 2 | 7,007 | Al Fitzmorris | Ross Grimsley | Al Fitzmorris | Ross Grimsley | | 234 | 202 | 32 |
| 1974-06-05 | @ BAL | 52 | L 4-5 | 26-26 | 3 | 7,277 | Bruce Dal Canton | Dave McNally | Bob Reynolds | Doug Bird | | 238 | 207 | 31 |
| 1974-06-07 | vs CLE | 53 | L 1-3 | 26-27 | 4 | 13,841 | Paul Splittorff | Gaylord Perry | Gaylord Perry | Paul Splittorff | | 239 | 210 | 29 |
| 1974-06-09 | vs CLE | 54 | L 6-8 | 26-28 | 4 | 19,049 | Steve Busby | Steve Kline | Steve Kline | Steve Busby | Fred Beene | 245 | 218 | 27 |
| 1974-06-11 | vs MIL | 55 | W 1-0 | 27-28 | 4 | 12,344 | Al Fitzmorris | Clyde Wright | Al Fitzmorris | Clyde Wright | | 246 | 218 | 28 |
| 1974-06-12 | vs MIL | 56 | W 4-3 | 28-28 | 2 | 11,872 | Bruce Dal Canton | Jim Colborn | Doug Bird | Tom Murphy | | 250 | 221 | 29 |
| 1974-06-13 | vs MIL | 57 | W 5-4 | 29-28 | 2 | 13,895 | Paul Splittorff | Jim Slaton | Paul Splittorff | Jim Slaton | Gene Garber | 255 | 225 | 30 |
| 1974-06-14 | @ DET | 58 | W 4-3 | 30-28 | 2 | 22,423 | Steve Busby | Lerrin LaGrow | Steve Busby | Lerrin LaGrow | | 259 | 228 | 31 |
| 1974-06-15 | @ DET | 59 | L 9-11 | 30-29 | 2 | 14,009 | Al Fitzmorris | Joe Coleman | Luke Walker | Joe Hoerner | | 268 | 239 | 29 |
| 1974-06-16 | @ DET | 60 | L 2-3 | 30-30 | 2 | 15,446 | Bruce Dal Canton | Mickey Lolich | Mickey Lolich | Bruce Dal Canton | | 270 | 242 | 28 |
| 1974-06-18 | @ MIL | 61 | W 7-0 | 31-30 | 2 | 17,719 | Paul Splittorff | Kevin Kobel | Paul Splittorff | Kevin Kobel | | 277 | 242 | 35 |
| 1974-06-19 | @ MIL | 62 | W 2-0 | 32-30 | 2 | 9,019 | Steve Busby | Clyde Wright | Steve Busby | Clyde Wright | | 279 | 242 | 37 |
| 1974-06-20 | @ OAK | 63 | L 0-4 | 32-31 | 2 | 4,662 | Al Fitzmorris | Catfish Hunter | Catfish Hunter | Al Fitzmorris | | 279 | 246 | 33 |
| 1974-06-21 | @ OAK | 64 | L 4-5 | 32-32 | 3 | 6,577 | Bruce Dal Canton | Dave Hamilton | Darold Knowles | Joe Hoerner | Rollie Fingers | 283 | 251 | 32 |
| 1974-06-22 | @ OAK | 65 | L 2-3 | 32-33 | 4 | 8,705 | Paul Splittorff | Ken Holtzman | Ken Holtzman | Paul Splittorff | | 285 | 254 | 31 |
| 1974-06-23 | @ OAK | 66 | W 4-1 | 33-33 | 3 | 9,891 | Lindy McDaniel | Glenn Abbott | Lindy McDaniel | Glenn Abbott | | 289 | 255 | 34 |
| 1974-06-24 | vs CHA | 67 | L 1-3 | 33-34 | 4 | 16,193 | Steve Busby | Wilbur Wood | Wilbur Wood | Steve Busby | Terry Forster | 290 | 258 | 32 |
| 1974-06-25 | vs CHA | 68 | L 9-10 | 33-35 | 4 | 11,797 | Al Fitzmorris | Joe Henderson | Terry Forster | Joe Hoerner | | 299 | 268 | 31 |
| 1974-06-26 | vs CHA | 69 | W 2-1 | 34-35 | 4 | 11,506 | Paul Splittorff | Jim Kaat | Paul Splittorff | Rich Gossage | | 301 | 269 | 32 |
| 1974-06-27 | vs OAK | 70 | W 5-4 | 35-35 | 3 | 24,894 | Lindy McDaniel | Ken Holtzman | Marty Pattin | Ken Holtzman | | 306 | 273 | 33 |
| 1974-06-28 | vs OAK | 71 | L 1-7 | 35-36 | 4 | 32,400 | Nelson Briles | Glenn Abbott | Glenn Abbott | Nelson Briles | | 307 | 280 | 27 |
| 1974-06-29 | vs OAK | 72 | W 2-0 | 36-36 | 3 | 39,474 | Steve Busby | Vida Blue | Steve Busby | Vida Blue | | 309 | 280 | 29 |
| 1974-06-30 | vs OAK | 73 | W 8-7 | 37-36 | 2 | 32,094 | Al Fitzmorris | Catfish Hunter | Gene Garber | Darold Knowles | | 317 | 287 | 30 |
| 1974-07-01 | @ CHA | 74 | W 9-0 | 38-36 | 2 | 17,494 | Bruce Dal Canton | Stan Bahnsen | Bruce Dal Canton | Stan Bahnsen | | 326 | 287 | 39 |
| 1974-07-02 | @ CHA | 75 | L 1-4 | 38-37 | 2 | 11,162 | Lindy McDaniel | Wilbur Wood | Wilbur Wood | Lindy McDaniel | | 327 | 291 | 36 |
| 1974-07-03 | @ CHA | 76 | W 5-3 | 39-37 | 2 | 13,795 | Paul Splittorff | Bill Moran | Paul Splittorff | Bill Moran | Doug Bird | 332 | 294 | 38 |
| 1974-07-04 | @ CHA | 77 | L 3-11 | 39-38 | 2 | 25,805 | Steve Busby | Jim Kaat | Jim Kaat | Steve Busby | Terry Forster | 335 | 305 | 30 |
| 1974-07-06 | @ BOS | 78 | W 5-3 | 40-38 | 2 | 23,331 | Nelson Briles | Rick Wise | Nelson Briles | Rick Wise | Al Fitzmorris | 340 | 308 | 32 |
| 1974-07-07 | @ BOS | 79 | W 11-9 | 41-39 | 2 | 0 | Bruce Dal Canton | Bill Lee | Joe Hoerner | Don Newhauser | | 351 | 317 | 34 |
| 1974-07-07 | @ BOS | 80 | L 3-5 | 41-39 | 2 | 21,146 | Lindy McDaniel | Roger Moret | Roger Moret | Marty Pattin | | 354 | 322 | 32 |
| 1974-07-08 | @ BOS | 81 | W 5-0 | 42-39 | 2 | 19,012 | Steve Busby | Dick Drago | Steve Busby | Dick Drago | | 359 | 322 | 37 |
| 1974-07-09 | vs NYA | 82 | L 2-8 | 42-40 | 2 | 17,511 | Paul Splittorff | Dave Pagan | Dave Pagan | Paul Splittorff | | 361 | 330 | 31 |
| 1974-07-10 | vs NYA | 83 | L 4-9 | 42-41 | 2 | 15,264 | Marty Pattin | Rudy May | Mike Wallace | Doug Bird | Sparky Lyle | 365 | 339 | 26 |
| 1974-07-11 | vs NYA | 84 | L 1-2 | 42-42 | 2 | 13,792 | Nelson Briles | Doc Medich | Doc Medich | Nelson Briles | | 366 | 341 | 25 |
| 1974-07-12 | vs DET | 85 | W 7-2 | 43-42 | 2 | 17,590 | Steve Busby | Mickey Lolich | Steve Busby | Mickey Lolich | | 373 | 343 | 30 |
| 1974-07-13 | vs DET | 86 | L 2-8 | 43-43 | 2 | 25,834 | Paul Splittorff | Woodie Fryman | Woodie Fryman | Paul Splittorff | | 375 | 351 | 24 |
| 1974-07-14 | vs DET | 87 | W 2-1 | 44-43 | 2 | 22,167 | Bruce Dal Canton | Joe Coleman | Doug Bird | Jim Ray | | 377 | 352 | 25 |
| 1974-07-15 | vs BOS | 88 | W 3-2 | 45-43 | 2 | 13,380 | Nelson Briles | Reggie Cleveland | Nelson Briles | Reggie Cleveland | Doug Bird | 380 | 354 | 26 |
| 1974-07-16 | vs BOS | 89 | W 5-4 | 46-43 | 2 | 16,852 | Steve Busby | Bill Lee | Steve Busby | Bill Lee | | 385 | 358 | 27 |
| 1974-07-17 | vs BOS | 90 | L 3-6 | 46-44 | 2 | 15,644 | Marty Pattin | Roger Moret | Roger Moret | Marty Pattin | | 388 | 364 | 24 |
| 1974-07-18 | @ NYA | 91 | L 6-10 | 46-45 | 3 | 12,615 | Paul Splittorff | Dick Tidrow | Mike Wallace | Paul Splittorff | | 394 | 374 | 20 |
| 1974-07-19 | @ NYA | 92 | W 5-4 | 47-45 | 3 | 15,703 | Bruce Dal Canton | Sam McDowell | Bruce Dal Canton | Sam McDowell | Doug Bird | 399 | 378 | 21 |
| 1974-07-20 | @ NYA | 93 | L 2-6 | 47-46 | 3 | 11,050 | Steve Busby | Doc Medich | Doc Medich | Steve Busby | | 401 | 384 | 17 |
| 1974-07-21 | @ NYA | 94 | L 4-5 | 47-47 | 3 | 36,825 | Nelson Briles | Pat Dobson | Sparky Lyle | Steve Mingori | | 405 | 389 | 16 |
| 1974-07-25 | @ CAL | 95 | W 2-1 | 48-47 | 3 | 11,334 | Paul Splittorff | Nolan Ryan | Paul Splittorff | Nolan Ryan | Doug Bird | 407 | 390 | 17 |
| 1974-07-26 | @ CAL | 96 | W 3-2 | 49-47 | 2 | 9,131 | Steve Busby | Dick Lange | Steve Busby | Luis Quintana | | 410 | 392 | 18 |
| 1974-07-27 | @ CAL | 97 | W 6-3 | 50-47 | 2 | 12,008 | Bruce Dal Canton | Ed Figueroa | Bruce Dal Canton | Ed Figueroa | | 416 | 395 | 21 |
| 1974-07-28 | @ TEX | 98 | L 4-6 | 50-48 | 2 | 11,746 | Nelson Briles | Jackie Brown | Jackie Brown | Nelson Briles | | 420 | 401 | 19 |
| 1974-07-29 | @ TEX | 99 | L 1-10 | 50-49 | 2 | 12,498 | Marty Pattin | Fergie Jenkins | Fergie Jenkins | Marty Pattin | | 421 | 411 | 10 |
| 1974-07-30 | @ MIN | 100 | L 3-7 | 50-50 | 3 | 12,294 | Paul Splittorff | Joe Decker | Joe Decker | Paul Splittorff | | 424 | 418 | 6 |
| 1974-07-31 | @ MIN | 101 | W 3-2 | 51-50 | 2 | 18,479 | Steve Busby | Bert Blyleven | Steve Busby | Bert Blyleven | Doug Bird | 427 | 420 | 7 |
| 1974-08-01 | vs TEX | 102 | L 1-3 | 51-51 | 3 | 13,770 | Bruce Dal Canton | Jackie Brown | Jackie Brown | Bruce Dal Canton | | 428 | 423 | 5 |
| 1974-08-02 | vs TEX | 103 | W 4-0 | 52-51 | 2 | 16,437 | Nelson Briles | Fergie Jenkins | Nelson Briles | Fergie Jenkins | | 432 | 423 | 9 |
| 1974-08-03 | vs CAL | 104 | L 3-4 | 52-52 | 2 | 15,277 | Paul Splittorff | Nolan Ryan | Nolan Ryan | Paul Splittorff | | 435 | 427 | 8 |
| 1974-08-04 | vs CAL | 105 | W 10-4 | 54-52 | 2 | 0 | Steve Busby | Dick Lange | Steve Busby | Dick Lange | Steve Mingori | 445 | 431 | 14 |
| 1974-08-04 | vs CAL | 106 | W 3-0 | 54-52 | 2 | 22,793 | Al Fitzmorris | Frank Tanana | Al Fitzmorris | Frank Tanana | Joe Hoerner | 448 | 431 | 17 |
| 1974-08-06 | vs MIN | 107 | W 17-3 | 55-52 | 2 | 13,301 | Bruce Dal Canton | Ray Corbin | Bruce Dal Canton | Ray Corbin | | 465 | 434 | 31 |
| 1974-08-07 | vs MIN | 108 | W 7-6 | 57-52 | 2 | 0 | Nelson Briles | Dave Goltz | Doug Bird | Bill Campbell | | 472 | 440 | 32 |
| 1974-08-07 | vs MIN | 109 | W 5-1 | 57-52 | 2 | 16,575 | Paul Splittorff | Bill Butler | Paul Splittorff | Bill Butler | | 477 | 441 | 36 |
| 1974-08-08 | vs MIN | 110 | L 2-3 | 57-53 | 2 | 12,749 | Al Fitzmorris | Joe Decker | Bill Campbell | Marty Pattin | | 479 | 444 | 35 |
| 1974-08-09 | vs MIL | 111 | W 13-3 | 58-53 | 2 | 15,064 | Steve Busby | Kevin Kobel | Steve Busby | Kevin Kobel | | 492 | 447 | 45 |
| 1974-08-10 | vs MIL | 112 | W 8-5 | 59-53 | 2 | 24,438 | Bruce Dal Canton | Jim Slaton | Marty Pattin | Jim Slaton | | 500 | 452 | 48 |
| 1974-08-11 | vs MIL | 113 | W 5-2 | 60-53 | 2 | 26,483 | Paul Splittorff | Clyde Wright | Paul Splittorff | Clyde Wright | Doug Bird | 505 | 454 | 51 |
| 1974-08-12 | @ DET | 114 | L 1-5 | 60-54 | 2 | 16,034 | Nelson Briles | Mickey Lolich | Mickey Lolich | Nelson Briles | | 506 | 459 | 47 |
| 1974-08-13 | @ DET | 115 | W 6-2 | 61-54 | 2 | 12,510 | Al Fitzmorris | Joe Coleman | Al Fitzmorris | Joe Coleman | | 512 | 461 | 51 |
| 1974-08-14 | @ DET | 116 | W 9-1 | 62-54 | 2 | 13,504 | Steve Busby | Fred Holdsworth | Steve Busby | Fred Holdsworth | | 521 | 462 | 59 |
| 1974-08-16 | @ BAL | 117 | L 0-1 | 62-55 | 2 | 18,896 | Bruce Dal Canton | Ross Grimsley | Ross Grimsley | Bruce Dal Canton | | 521 | 463 | 58 |
| 1974-08-17 | @ BAL | 118 | W 3-2 | 63-55 | 2 | 19,665 | Paul Splittorff | Jim Palmer | Steve Mingori | Bob Reynolds | | 524 | 465 | 59 |
| 1974-08-18 | @ BAL | 119 | L 0-1 | 63-56 | 2 | 10,193 | Steve Busby | Dave McNally | Dave McNally | Steve Busby | | 524 | 466 | 58 |
| 1974-08-20 | @ CLE | 120 | W 2-0 | 64-56 | 2 | 11,902 | Al Fitzmorris | Gaylord Perry | Al Fitzmorris | Gaylord Perry | Lindy McDaniel | 526 | 466 | 60 |
| 1974-08-21 | @ CLE | 121 | L 6-7 | 64-57 | 2 | 11,294 | Bruce Dal Canton | Dick Bosman | Tom Buskey | Steve Mingori | | 532 | 473 | 59 |
| 1974-08-22 | @ CLE | 122 | W 3-1 | 65-57 | 2 | 17,723 | Paul Splittorff | Jim Perry | Paul Splittorff | Jim Perry | | 535 | 474 | 61 |
| 1974-08-23 | @ MIL | 123 | W 8-4 | 66-58 | 2 | 0 | Steve Busby | Bill Champion | Steve Busby | Bill Champion | Steve Mingori | 543 | 478 | 65 |
| 1974-08-23 | @ MIL | 124 | L 0-1 | 66-58 | 2 | 15,659 | Nelson Briles | Jim Slaton | Tom Murphy | Lindy McDaniel | | 543 | 479 | 64 |
| 1974-08-24 | @ MIL | 125 | W 4-0 | 67-58 | 2 | 14,433 | Al Fitzmorris | Eduardo Rodriguez | Al Fitzmorris | Eduardo Rodriguez | | 547 | 479 | 68 |
| 1974-08-25 | @ MIL | 126 | W 2-0 | 68-58 | 2 | 12,932 | Bruce Dal Canton | Kevin Kobel | Bruce Dal Canton | Kevin Kobel | | 549 | 479 | 70 |
| 1974-08-26 | vs CLE | 127 | L 1-4 | 68-59 | 2 | 12,958 | Paul Splittorff | Jim Perry | Jim Perry | Paul Splittorff | | 550 | 483 | 67 |
| 1974-08-27 | vs CLE | 128 | L 8-12 | 69-60 | 2 | 0 | Steve Busby | Fritz Peterson | Tom Hilgendorf | Steve Busby | Tom Buskey | 558 | 495 | 63 |
| 1974-08-27 | vs CLE | 129 | W 13-2 | 69-60 | 2 | 13,980 | Nelson Briles | Milt Wilcox | Nelson Briles | Milt Wilcox | | 571 | 497 | 74 |
| 1974-08-28 | vs CLE | 130 | L 1-7 | 69-61 | 2 | 9,085 | Al Fitzmorris | Gaylord Perry | Gaylord Perry | Al Fitzmorris | | 572 | 504 | 68 |
| 1974-08-30 | vs BAL | 131 | L 2-9 | 69-62 | 2 | 16,277 | Bruce Dal Canton | Mike Cuellar | Mike Cuellar | Bruce Dal Canton | | 574 | 513 | 61 |
| 1974-08-31 | vs BAL | 132 | L 2-3 | 69-63 | 2 | 18,737 | Paul Splittorff | Jim Palmer | Jim Palmer | Paul Splittorff | Grant Jackson | 576 | 516 | 60 |
| 1974-09-01 | vs BAL | 133 | L 1-7 | 69-64 | 2 | 15,499 | Steve Busby | Dave McNally | Dave McNally | Steve Busby | | 577 | 523 | 54 |
| 1974-09-02 | vs CHA | 134 | L 4-6 | 69-65 | 2 | 7,677 | Al Fitzmorris | Wilbur Wood | Wilbur Wood | Doug Bird | | 581 | 529 | 52 |
| 1974-09-03 | vs CHA | 135 | L 1-2 | 69-66 | 2 | 7,173 | Bruce Dal Canton | Jack Kucek | Jack Kucek | Bruce Dal Canton | Terry Forster | 582 | 531 | 51 |
| 1974-09-04 | vs CHA | 136 | L 0-7 | 69-67 | 3 | 7,584 | Paul Splittorff | Jim Kaat | Jim Kaat | Paul Splittorff | | 582 | 538 | 44 |
| 1974-09-05 | vs MIN | 137 | L 1-4 | 69-68 | 3 | 7,421 | Steve Busby | Vic Albury | Vic Albury | Steve Busby | | 583 | 542 | 41 |
| 1974-09-07 | vs MIN | 138 | W 1-0 | 70-68 | 3 | 14,131 | Al Fitzmorris | Joe Decker | Al Fitzmorris | Joe Decker | | 584 | 542 | 42 |
| 1974-09-08 | vs MIN | 139 | L 4-8 | 70-69 | 3 | 11,847 | Bruce Dal Canton | Bert Blyleven | Bert Blyleven | Bruce Dal Canton | Bill Campbell | 588 | 550 | 38 |
| 1974-09-09 | @ OAK | 140 | L 0-3 | 70-71 | 4 | 0 | Steve Busby | Vida Blue | Vida Blue | Steve Busby | | 588 | 553 | 35 |
| 1974-09-09 | @ OAK | 141 | L 0-7 | 70-71 | 4 | 46,780 | Paul Splittorff | Catfish Hunter | Catfish Hunter | Paul Splittorff | | 588 | 560 | 28 |
| 1974-09-10 | @ CAL | 142 | L 2-8 | 70-72 | 4 | 4,491 | Dennis Leonard | Frank Tanana | Frank Tanana | Dennis Leonard | | 590 | 568 | 22 |
| 1974-09-11 | @ CAL | 143 | L 2-3 | 70-73 | 4 | 5,170 | Al Fitzmorris | Nolan Ryan | Nolan Ryan | Al Fitzmorris | | 592 | 571 | 21 |
| 1974-09-13 | @ MIN | 144 | L 5-6 | 70-74 | 5 | 3,815 | Steve Busby | Ray Corbin | Tom Johnson | Doug Bird | | 597 | 577 | 20 |
| 1974-09-14 | @ MIN | 145 | L 5-7 | 71-75 | 5 | 0 | Paul Splittorff | Dave Goltz | Dave Goltz | Paul Splittorff | Tom Johnson | 602 | 584 | 18 |
| 1974-09-14 | @ MIN | 146 | W 13-3 | 71-75 | 5 | 7,462 | Nelson Briles | Jim Hughes | Nelson Briles | Jim Hughes | | 615 | 587 | 28 |
| 1974-09-15 | @ MIN | 147 | L 2-5 | 71-76 | 5 | 6,754 | Dennis Leonard | Joe Decker | Joe Decker | Dennis Leonard | | 617 | 592 | 25 |
| 1974-09-16 | @ MIN | 148 | L 2-7 | 71-77 | 5 | 4,095 | Al Fitzmorris | Bert Blyleven | Bert Blyleven | Al Fitzmorris | | 619 | 599 | 20 |
| 1974-09-17 | vs OAK | 149 | W 2-1 | 72-77 | 5 | 14,412 | Steve Busby | Catfish Hunter | Steve Busby | Catfish Hunter | | 621 | 600 | 21 |
| 1974-09-18 | vs OAK | 150 | L 4-5 | 72-78 | 5 | 14,976 | Paul Splittorff | Ken Holtzman | Ken Holtzman | Paul Splittorff | Rollie Fingers | 625 | 605 | 20 |
| 1974-09-19 | vs OAK | 151 | W 4-3 | 73-78 | 5 | 14,218 | Nelson Briles | Vida Blue | Doug Bird | Rollie Fingers | | 629 | 608 | 21 |
| 1974-09-21 | @ TEX | 152 | W 4-1 | 75-78 | 5 | 0 | Al Fitzmorris | Jim Bibby | Al Fitzmorris | Jim Bibby | | 633 | 609 | 24 |
| 1974-09-21 | @ TEX | 153 | W 8-5 | 75-78 | 5 | 20,085 | Steve Busby | Jackie Brown | Steve Busby | Steve Foucault | Doug Bird | 641 | 614 | 27 |
| 1974-09-22 | @ TEX | 154 | L 3-4 | 75-79 | 5 | 7,191 | Dennis Leonard | Fergie Jenkins | Fergie Jenkins | Dennis Leonard | | 644 | 618 | 26 |
| 1974-09-24 | vs CAL | 155 | L 3-9 | 75-80 | 5 | 7,003 | Paul Splittorff | Nolan Ryan | Nolan Ryan | Paul Splittorff | | 647 | 627 | 20 |
| 1974-09-25 | vs CAL | 156 | L 0-7 | 75-81 | 5 | 6,766 | Nelson Briles | Andy Hassler | Andy Hassler | Nelson Briles | Orlando Pena | 647 | 634 | 13 |
| 1974-09-26 | vs CAL | 157 | W 10-1 | 76-81 | 5 | 6,795 | Steve Busby | Chuck Dobson | Steve Busby | Chuck Dobson | | 657 | 635 | 22 |
| 1974-09-27 | vs TEX | 158 | W 5-4 | 77-81 | 5 | 7,746 | Al Fitzmorris | Fergie Jenkins | Al Fitzmorris | Steve Foucault | | 662 | 639 | 23 |
| 1974-09-28 | vs TEX | 159 | L 0-11 | 77-82 | 5 | 8,839 | Dennis Leonard | Jackie Brown | Jackie Brown | Dennis Leonard | | 662 | 650 | 12 |
| 1974-09-29 | vs TEX | 160 | L 0-5 | 77-83 | 5 | 8,928 | Nelson Briles | Bill Hands | Bill Hands | Nelson Briles | | 662 | 655 | 7 |
| 1974-10-01 | @ CHA | 161 | L 1-2 | 77-84 | 5 | 4,430 | Doug Bird | Jim Kaat | Jim Kaat | Doug Bird | | 663 | 657 | 6 |
| 1974-10-02 | @ CHA | 162 | L 4-5 | 77-85 | 5 | 1,969 | Aurelio Lopez | Stan Bahnsen | Rich Gossage | Bruce Dal Canton | | 667 | 662 | 5 |