| 1974-04-05 | @ BAL | 1 | L 2-3 | 0-1 | 4 | 23,918 | Mickey Lolich | Jim Palmer | Jim Palmer | Mickey Lolich | Grant Jackson | 2 | 3 | -1 |
| 1974-04-06 | @ BAL | 2 | W 3-2 | 1-1 | 4 | 3,749 | Joe Coleman | Dave McNally | John Hiller | Dave McNally | | 5 | 5 | 0 |
| 1974-04-07 | @ BAL | 3 | L 1-5 | 2-2 | 4 | 0 | Woodie Fryman | Ross Grimsley | Ross Grimsley | Woodie Fryman | | 6 | 10 | -4 |
| 1974-04-07 | @ BAL | 4 | W 8-4 | 2-2 | 4 | 16,400 | Lerrin LaGrow | Mike Cuellar | John Hiller | Grant Jackson | | 14 | 14 | 0 |
| 1974-04-09 | vs NYA | 5 | L 0-3 | 2-3 | 5 | 44,047 | Mickey Lolich | Steve Kline | Steve Kline | Mickey Lolich | Sparky Lyle | 14 | 17 | -3 |
| 1974-04-11 | vs NYA | 6 | W 4-1 | 3-3 | 4 | 6,640 | Joe Coleman | Mel Stottlemyre | Joe Coleman | Mel Stottlemyre | | 18 | 18 | 0 |
| 1974-04-12 | @ BOS | 7 | L 3-6 | 3-4 | 5 | 8,481 | Lerrin LaGrow | Bill Lee | Bill Lee | Lerrin LaGrow | | 21 | 24 | -3 |
| 1974-04-13 | @ BOS | 8 | L 1-8 | 3-5 | 5 | 8,159 | Bill Slayback | Rick Wise | Rick Wise | Bill Slayback | | 22 | 32 | -10 |
| 1974-04-14 | @ BOS | 9 | L 5-7 | 3-6 | 6 | 11,274 | Mickey Lolich | Juan Marichal | Dick Drago | Mickey Lolich | Diego Segui | 27 | 39 | -12 |
| 1974-04-15 | @ BOS | 10 | W 1-0 | 4-6 | 5 | 23,498 | Joe Coleman | Reggie Cleveland | Joe Coleman | Reggie Cleveland | | 28 | 39 | -11 |
| 1974-04-17 | vs BAL | 11 | L 1-6 | 4-7 | 6 | 12,166 | Woodie Fryman | Jim Palmer | Jim Palmer | Woodie Fryman | | 29 | 45 | -16 |
| 1974-04-20 | vs MIL | 12 | L 1-3 | 4-8 | 5 | 9,485 | Joe Coleman | Clyde Wright | Clyde Wright | Joe Coleman | | 30 | 48 | -18 |
| 1974-04-21 | vs MIL | 13 | W 6-5 | 5-8 | 5 | 19,654 | Mickey Lolich | Jim Colborn | John Hiller | Tom Murphy | | 36 | 53 | -17 |
| 1974-04-23 | vs MIN | 14 | L 0-1 | 5-9 | 5 | 5,422 | Lerrin LaGrow | Dick Woodson | Bill Campbell | Lerrin LaGrow | | 36 | 54 | -18 |
| 1974-04-24 | vs MIN | 15 | W 8-4 | 6-9 | 5 | 6,804 | Joe Coleman | Bill Hands | Joe Coleman | Bill Hands | John Hiller | 44 | 58 | -14 |
| 1974-04-26 | @ CHA | 16 | L 2-8 | 6-10 | 5 | 16,152 | Mickey Lolich | Stan Bahnsen | Stan Bahnsen | Mickey Lolich | | 46 | 66 | -20 |
| 1974-04-27 | @ CHA | 17 | W 8-3 | 7-10 | 5 | 32,737 | Lerrin LaGrow | Jim Kaat | Lerrin LaGrow | Jim Kaat | John Hiller | 54 | 69 | -15 |
| 1974-04-28 | @ CHA | 18 | W 6-4 | 8-10 | 5 | 14,443 | Joe Coleman | Wilbur Wood | Joe Coleman | Wilbur Wood | John Hiller | 60 | 73 | -13 |
| 1974-04-30 | @ KCA | 19 | W 7-2 | 9-10 | 5 | 9,310 | Mickey Lolich | Paul Splittorff | Mickey Lolich | Paul Splittorff | | 67 | 75 | -8 |
| 1974-05-01 | @ KCA | 20 | W 2-1 | 10-10 | 4 | 9,146 | Lerrin LaGrow | Steve Busby | Lerrin LaGrow | Steve Busby | | 69 | 76 | -7 |
| 1974-05-02 | @ KCA | 21 | W 9-7 | 11-10 | 4 | 9,162 | Joe Coleman | Al Fitzmorris | Joe Coleman | Al Fitzmorris | | 78 | 83 | -5 |
| 1974-05-03 | @ MIN | 22 | W 4-3 | 12-10 | 2 | 4,467 | Bill Slayback | Joe Decker | Bill Slayback | Joe Decker | John Hiller | 82 | 86 | -4 |
| 1974-05-04 | @ MIN | 23 | L 0-10 | 12-11 | 2 | 4,540 | Mickey Lolich | Bert Blyleven | Bert Blyleven | Mickey Lolich | | 82 | 96 | -14 |
| 1974-05-05 | @ MIN | 24 | L 3-8 | 12-12 | 2 | 18,673 | Woodie Fryman | Vic Albury | Vic Albury | Woodie Fryman | | 85 | 104 | -19 |
| 1974-05-06 | vs CHA | 25 | W 5-4 | 13-12 | 2 | 7,355 | Joe Coleman | Stan Perzanowski | John Hiller | Cy Acosta | | 90 | 108 | -18 |
| 1974-05-07 | vs CHA | 26 | L 0-1 | 13-13 | 4 | 7,327 | Lerrin LaGrow | Wilbur Wood | Wilbur Wood | Lerrin LaGrow | | 90 | 109 | -19 |
| 1974-05-10 | vs BOS | 27 | W 6-5 | 14-13 | 3 | 16,322 | Mickey Lolich | Reggie Cleveland | John Hiller | Diego Segui | | 96 | 114 | -18 |
| 1974-05-11 | vs BOS | 28 | L 5-8 | 14-14 | 4 | 10,487 | Joe Coleman | Roger Moret | Lance Clemons | John Hiller | | 101 | 122 | -21 |
| 1974-05-12 | vs BOS | 29 | L 3-4 | 14-15 | 6 | 23,686 | Lerrin LaGrow | Bill Lee | Bill Lee | John Hiller | Diego Segui | 104 | 126 | -22 |
| 1974-05-14 | @ NYA | 30 | W 5-2 | 15-15 | 4 | 9,598 | Mickey Lolich | Pat Dobson | Mickey Lolich | Pat Dobson | | 109 | 128 | -19 |
| 1974-05-15 | @ NYA | 31 | W 6-5 | 16-15 | 3 | 7,360 | Joe Coleman | Dick Tidrow | Joe Coleman | Cecil Upshaw | John Hiller | 115 | 133 | -18 |
| 1974-05-17 | @ CLE | 32 | W 4-3 | 17-15 | 2 | 11,292 | Lerrin LaGrow | Fritz Peterson | Lerrin LaGrow | Fritz Peterson | John Hiller | 119 | 136 | -17 |
| 1974-05-18 | @ CLE | 33 | W 3-2 | 18-15 | 1 | 6,597 | Mickey Lolich | Jim Perry | Mickey Lolich | Jim Perry | | 122 | 138 | -16 |
| 1974-05-19 | @ CLE | 34 | L 1-2 | 18-17 | 2 | 0 | Joe Coleman | Gaylord Perry | Gaylord Perry | Joe Coleman | | 123 | 140 | -17 |
| 1974-05-19 | @ CLE | 35 | L 4-9 | 18-17 | 2 | 49,419 | Bill Slayback | Bob Johnson | Bob Johnson | Bill Slayback | | 127 | 149 | -22 |
| 1974-05-20 | @ MIL | 36 | L 4-6 | 18-18 | 4 | 5,835 | Woodie Fryman | Ed Sprague | Ed Sprague | John Hiller | Eduardo Rodriguez | 131 | 155 | -24 |
| 1974-05-21 | @ MIL | 37 | L 5-6 | 18-19 | 5 | 6,885 | Lerrin LaGrow | Clyde Wright | Eduardo Rodriguez | John Hiller | | 136 | 161 | -25 |
| 1974-05-22 | @ MIL | 38 | W 6-4 | 19-19 | 4 | 7,698 | Mickey Lolich | Kevin Kobel | Mickey Lolich | Kevin Kobel | | 142 | 165 | -23 |
| 1974-05-23 | @ MIL | 39 | L 3-7 | 19-20 | 5 | 10,505 | Joe Coleman | Jim Slaton | Jim Slaton | Joe Coleman | | 145 | 172 | -27 |
| 1974-05-24 | vs CLE | 40 | L 1-3 | 19-21 | 5 | 15,149 | Bill Slayback | Fritz Peterson | Fritz Peterson | Bill Slayback | | 146 | 175 | -29 |
| 1974-05-25 | vs CLE | 41 | W 5-4 | 20-21 | 5 | 12,483 | Lerrin LaGrow | Bob Johnson | Luke Walker | Fred Beene | John Hiller | 151 | 179 | -28 |
| 1974-05-26 | vs CLE | 42 | W 2-1 | 21-21 | 4 | 16,492 | Mickey Lolich | Steve Kline | Mickey Lolich | Steve Kline | | 153 | 180 | -27 |
| 1974-05-27 | @ OAK | 43 | L 2-12 | 21-22 | 4 | 10,084 | Joe Coleman | Vida Blue | Vida Blue | Joe Coleman | | 155 | 192 | -37 |
| 1974-05-28 | @ OAK | 44 | W 3-1 | 22-22 | 3 | 3,093 | Woodie Fryman | Catfish Hunter | Woodie Fryman | Catfish Hunter | John Hiller | 158 | 193 | -35 |
| 1974-05-29 | @ OAK | 45 | L 1-4 | 22-23 | 4 | 3,783 | Lerrin LaGrow | Ken Holtzman | Ken Holtzman | Lerrin LaGrow | | 159 | 197 | -38 |
| 1974-05-31 | @ CAL | 46 | L 3-5 | 22-24 | 4 | 10,760 | Mickey Lolich | Bill Singer | Bill Singer | Mickey Lolich | | 162 | 202 | -40 |
| 1974-06-01 | @ CAL | 47 | L 1-4 | 22-25 | 6 | 16,481 | Joe Coleman | Nolan Ryan | Nolan Ryan | Joe Coleman | | 163 | 206 | -43 |
| 1974-06-02 | @ CAL | 48 | W 2-0 | 23-25 | 6 | 16,550 | Woodie Fryman | Dick Lange | Woodie Fryman | Dick Lange | John Hiller | 165 | 206 | -41 |
| 1974-06-04 | vs OAK | 49 | L 0-4 | 24-26 | 5 | 0 | Mickey Lolich | Ken Holtzman | Ken Holtzman | Mickey Lolich | | 165 | 210 | -45 |
| 1974-06-04 | vs OAK | 50 | W 4-1 | 24-26 | 5 | 33,331 | Lerrin LaGrow | Dave Hamilton | Lerrin LaGrow | Dave Hamilton | | 169 | 211 | -42 |
| 1974-06-05 | vs OAK | 51 | L 1-9 | 24-27 | 5 | 20,607 | Joe Coleman | Vida Blue | Vida Blue | Joe Coleman | | 170 | 220 | -50 |
| 1974-06-07 | vs CAL | 52 | W 5-4 | 25-27 | 5 | 15,007 | Woodie Fryman | Dick Lange | John Hiller | John Cumberland | | 175 | 224 | -49 |
| 1974-06-08 | vs CAL | 53 | W 5-2 | 26-27 | 5 | 12,053 | Mickey Lolich | Frank Tanana | Mickey Lolich | Frank Tanana | | 180 | 226 | -46 |
| 1974-06-09 | vs CAL | 54 | W 5-3 | 27-27 | 4 | 42,491 | Lerrin LaGrow | Nolan Ryan | Lerrin LaGrow | Nolan Ryan | John Hiller | 185 | 229 | -44 |
| 1974-06-10 | vs TEX | 55 | L 3-6 | 27-28 | 5 | 22,696 | Joe Coleman | Jackie Brown | Jackie Brown | Joe Coleman | | 188 | 235 | -47 |
| 1974-06-11 | vs TEX | 56 | W 8-6 | 28-28 | 4 | 13,604 | Woodie Fryman | David Clyde | Woodie Fryman | David Clyde | Jim Ray | 196 | 241 | -45 |
| 1974-06-12 | vs TEX | 57 | W 7-0 | 29-28 | 4 | 17,552 | Mickey Lolich | Fergie Jenkins | Mickey Lolich | Fergie Jenkins | | 203 | 241 | -38 |
| 1974-06-14 | vs KCA | 58 | L 3-4 | 29-29 | 4 | 22,423 | Lerrin LaGrow | Steve Busby | Steve Busby | Lerrin LaGrow | | 206 | 245 | -39 |
| 1974-06-15 | vs KCA | 59 | W 11-9 | 30-29 | 4 | 14,009 | Joe Coleman | Al Fitzmorris | Luke Walker | Joe Hoerner | | 217 | 254 | -37 |
| 1974-06-16 | vs KCA | 60 | W 3-2 | 31-29 | 3 | 15,446 | Mickey Lolich | Bruce Dal Canton | Mickey Lolich | Bruce Dal Canton | | 220 | 256 | -36 |
| 1974-06-17 | @ TEX | 61 | W 6-4 | 32-29 | 3 | 11,471 | Woodie Fryman | Fergie Jenkins | John Hiller | Fergie Jenkins | | 226 | 260 | -34 |
| 1974-06-18 | @ TEX | 62 | L 0-6 | 32-30 | 4 | 13,953 | Lerrin LaGrow | Jim Bibby | Jim Bibby | Lerrin LaGrow | | 226 | 266 | -40 |
| 1974-06-19 | @ TEX | 63 | W 4-2 | 33-30 | 4 | 14,870 | Joe Coleman | Jackie Brown | John Hiller | Jackie Brown | | 230 | 268 | -38 |
| 1974-06-21 | @ NYA | 64 | W 3-2 | 34-30 | 2 | 13,661 | Mickey Lolich | Pat Dobson | Mickey Lolich | Cecil Upshaw | | 233 | 270 | -37 |
| 1974-06-22 | @ NYA | 65 | W 4-1 | 35-30 | 2 | 13,506 | Woodie Fryman | Dick Tidrow | John Hiller | Dick Tidrow | | 237 | 271 | -34 |
| 1974-06-23 | @ NYA | 66 | L 1-4 | 35-31 | 2 | 19,073 | Joe Coleman | Rudy May | Rudy May | Joe Coleman | | 238 | 275 | -37 |
| 1974-06-24 | @ BAL | 67 | L 1-3 | 35-32 | 3 | 6,546 | Lerrin LaGrow | Doyle Alexander | Doyle Alexander | Lerrin LaGrow | | 239 | 278 | -39 |
| 1974-06-25 | @ BAL | 68 | W 2-0 | 36-32 | 2 | 10,016 | Mickey Lolich | Mike Cuellar | Mickey Lolich | Mike Cuellar | | 241 | 278 | -37 |
| 1974-06-26 | @ BAL | 69 | L 4-5 | 36-33 | 3 | 8,170 | Woodie Fryman | Ross Grimsley | Ross Grimsley | John Hiller | | 245 | 283 | -38 |
| 1974-06-27 | vs MIL | 70 | L 1-5 | 36-34 | 4 | 15,298 | Joe Coleman | Clyde Wright | Clyde Wright | Joe Coleman | | 246 | 288 | -42 |
| 1974-06-28 | vs MIL | 71 | W 9-7 | 37-34 | 3 | 22,431 | Luke Walker | Kevin Kobel | Luke Walker | Kevin Kobel | | 255 | 295 | -40 |
| 1974-06-29 | vs MIL | 72 | L 0-9 | 37-35 | 4 | 23,574 | Mickey Lolich | Jim Colborn | Jim Colborn | Mickey Lolich | | 255 | 304 | -49 |
| 1974-06-30 | vs MIL | 73 | L 1-4 | 38-36 | 4 | 0 | Woodie Fryman | Ed Sprague | Ed Sprague | Woodie Fryman | Tom Murphy | 256 | 308 | -52 |
| 1974-06-30 | vs MIL | 74 | W 3-2 | 38-36 | 4 | 27,050 | Lerrin LaGrow | Jim Slaton | Lerrin LaGrow | Jim Slaton | | 259 | 310 | -51 |
| 1974-07-01 | vs NYA | 75 | W 4-3 | 39-36 | 4 | 21,532 | Joe Coleman | Doc Medich | John Hiller | Doc Medich | | 263 | 313 | -50 |
| 1974-07-02 | vs NYA | 76 | W 4-2 | 40-36 | 3 | 13,866 | Luke Walker | Pat Dobson | Luke Walker | Pat Dobson | Jim Ray | 267 | 315 | -48 |
| 1974-07-03 | vs NYA | 77 | W 8-6 | 41-36 | 3 | 17,846 | Mickey Lolich | Dave Pagan | John Hiller | Sparky Lyle | | 275 | 321 | -46 |
| 1974-07-04 | vs NYA | 78 | L 4-6 | 41-37 | 4 | 15,058 | Woodie Fryman | Dick Tidrow | Dick Tidrow | John Hiller | | 279 | 327 | -48 |
| 1974-07-05 | vs CHA | 79 | W 9-6 | 43-37 | 3 | 0 | Joe Coleman | Stan Bahnsen | Joe Coleman | Stan Bahnsen | | 288 | 333 | -45 |
| 1974-07-05 | vs CHA | 80 | W 7-4 | 43-37 | 3 | 25,819 | Lerrin LaGrow | Rich Gossage | Lerrin LaGrow | Bill Moran | | 295 | 337 | -42 |
| 1974-07-06 | vs CHA | 81 | L 8-9 | 43-38 | 4 | 17,470 | Luke Walker | Wilbur Wood | Wilbur Wood | Luke Walker | Terry Forster | 303 | 346 | -43 |
| 1974-07-07 | vs CHA | 82 | L 1-3 | 43-39 | 4 | 31,680 | Mickey Lolich | Bart Johnson | Bart Johnson | Mickey Lolich | | 304 | 349 | -45 |
| 1974-07-08 | @ MIN | 83 | L 2-6 | 43-40 | 4 | 7,343 | Woodie Fryman | Bert Blyleven | Bert Blyleven | Woodie Fryman | | 306 | 355 | -49 |
| 1974-07-09 | @ MIN | 84 | L 2-3 | 43-41 | 4 | 6,525 | Joe Coleman | Vic Albury | Bill Hands | John Hiller | | 308 | 358 | -50 |
| 1974-07-10 | @ MIN | 85 | L 6-11 | 43-42 | 5 | 6,884 | Lerrin LaGrow | Dave Goltz | Tom Burgmeier | Jim Ray | | 314 | 369 | -55 |
| 1974-07-12 | @ KCA | 86 | L 2-7 | 43-43 | 5 | 17,590 | Mickey Lolich | Steve Busby | Steve Busby | Mickey Lolich | | 316 | 376 | -60 |
| 1974-07-13 | @ KCA | 87 | W 8-2 | 44-43 | 5 | 25,834 | Woodie Fryman | Paul Splittorff | Woodie Fryman | Paul Splittorff | | 324 | 378 | -54 |
| 1974-07-14 | @ KCA | 88 | L 1-2 | 44-44 | 5 | 22,167 | Joe Coleman | Bruce Dal Canton | Doug Bird | Jim Ray | | 325 | 380 | -55 |
| 1974-07-15 | @ CHA | 89 | L 2-3 | 44-45 | 5 | 15,033 | Lerrin LaGrow | Bart Johnson | Rich Gossage | Lerrin LaGrow | | 327 | 383 | -56 |
| 1974-07-16 | @ CHA | 90 | L 0-6 | 44-46 | 6 | 14,876 | Mickey Lolich | Jim Kaat | Jim Kaat | Mickey Lolich | | 327 | 389 | -62 |
| 1974-07-17 | @ CHA | 91 | L 1-7 | 44-47 | 6 | 14,022 | Woodie Fryman | Wilbur Wood | Wilbur Wood | Woodie Fryman | | 328 | 396 | -68 |
| 1974-07-18 | vs MIN | 92 | W 5-3 | 45-47 | 6 | 14,383 | Joe Coleman | Bill Butler | Joe Coleman | Bill Butler | | 333 | 399 | -66 |
| 1974-07-19 | vs MIN | 93 | L 5-7 | 45-48 | 6 | 19,138 | Lerrin LaGrow | Vic Albury | Dave Goltz | Lerrin LaGrow | Tom Burgmeier | 338 | 406 | -68 |
| 1974-07-20 | vs MIN | 94 | L 6-12 | 45-49 | 6 | 23,593 | Mickey Lolich | Joe Decker | Joe Decker | Mickey Lolich | Bill Campbell | 344 | 418 | -74 |
| 1974-07-21 | vs MIN | 95 | L 7-10 | 45-50 | 6 | 17,269 | Luke Walker | Bert Blyleven | Bert Blyleven | Luke Walker | Tom Burgmeier | 351 | 428 | -77 |
| 1974-07-25 | vs BOS | 96 | L 4-12 | 45-51 | 6 | 17,005 | Mickey Lolich | Roger Moret | Roger Moret | Mickey Lolich | Dick Drago | 355 | 440 | -85 |
| 1974-07-26 | vs BOS | 97 | W 1-0 | 46-51 | 6 | 26,922 | Joe Coleman | Reggie Cleveland | Joe Coleman | Reggie Cleveland | | 356 | 440 | -84 |
| 1974-07-27 | @ CLE | 98 | L 2-3 | 46-52 | 6 | 12,075 | Lerrin LaGrow | Jim Perry | Jim Perry | Lerrin LaGrow | Tom Buskey | 358 | 443 | -85 |
| 1974-07-28 | @ CLE | 99 | W 6-3 | 47-52 | 6 | 24,809 | Luke Walker | Steve Arlin | John Hiller | Fred Beene | | 364 | 446 | -82 |
| 1974-07-29 | @ CLE | 100 | W 8-2 | 48-52 | 6 | 18,708 | Mickey Lolich | Fritz Peterson | Mickey Lolich | Fritz Peterson | | 372 | 448 | -76 |
| 1974-07-30 | @ BOS | 101 | W 7-5 | 49-52 | 6 | 21,456 | Joe Coleman | Reggie Cleveland | John Hiller | Reggie Cleveland | | 379 | 453 | -74 |
| 1974-07-31 | @ BOS | 102 | L 4-5 | 49-53 | 6 | 24,935 | Lerrin LaGrow | Luis Tiant | Luis Tiant | Lerrin LaGrow | | 383 | 458 | -75 |
| 1974-08-01 | @ MIL | 103 | W 2-0 | 50-53 | 6 | 9,010 | Woodie Fryman | Jim Slaton | Woodie Fryman | Jim Slaton | | 385 | 458 | -73 |
| 1974-08-02 | @ MIL | 104 | W 4-1 | 51-53 | 4 | 22,160 | Dave Lemanczyk | Clyde Wright | Dave Lemanczyk | Clyde Wright | | 389 | 459 | -70 |
| 1974-08-03 | vs BAL | 105 | L 2-6 | 51-54 | 5 | 30,019 | Mickey Lolich | Ross Grimsley | Ross Grimsley | Mickey Lolich | | 391 | 465 | -74 |
| 1974-08-04 | vs BAL | 106 | W 6-1 | 52-55 | 4 | 0 | Joe Coleman | Mike Cuellar | Joe Coleman | Mike Cuellar | | 397 | 466 | -69 |
| 1974-08-04 | vs BAL | 107 | L 3-9 | 52-55 | 4 | 34,317 | Lerrin LaGrow | Dave McNally | Dave McNally | Lerrin LaGrow | | 400 | 475 | -75 |
| 1974-08-05 | vs BAL | 108 | L 4-7 | 52-57 | 6 | 0 | Woodie Fryman | Wayne Garland | Wayne Garland | Woodie Fryman | Ross Grimsley | 404 | 482 | -78 |
| 1974-08-05 | vs BAL | 109 | L 3-6 | 52-57 | 6 | 37,030 | Luke Walker | Doyle Alexander | Doyle Alexander | Luke Walker | Grant Jackson | 407 | 488 | -81 |
| 1974-08-06 | vs CLE | 110 | L 7-9 | 52-58 | 5 | 14,234 | Dave Lemanczyk | Jim Perry | Milt Wilcox | Jim Ray | Tom Buskey | 414 | 497 | -83 |
| 1974-08-07 | vs CLE | 111 | W 3-2 | 53-58 | 5 | 13,633 | Mickey Lolich | Fritz Peterson | Mickey Lolich | Fred Beene | | 417 | 499 | -82 |
| 1974-08-08 | vs CLE | 112 | W 4-3 | 54-58 | 5 | 12,408 | Joe Coleman | Steve Arlin | Jim Ray | Tom Buskey | | 421 | 502 | -81 |
| 1974-08-09 | @ TEX | 113 | L 3-4 | 54-59 | 5 | 10,620 | Fred Holdsworth | Jackie Brown | Steve Foucault | John Hiller | | 424 | 506 | -82 |
| 1974-08-10 | @ TEX | 114 | L 4-5 | 54-60 | 5 | 37,737 | Lerrin LaGrow | Fergie Jenkins | Fergie Jenkins | Lerrin LaGrow | | 428 | 511 | -83 |
| 1974-08-11 | @ TEX | 115 | L 0-9 | 54-61 | 5 | 11,434 | Dave Lemanczyk | Jim Bibby | Jim Bibby | Dave Lemanczyk | | 428 | 520 | -92 |
| 1974-08-12 | vs KCA | 116 | W 5-1 | 55-61 | 5 | 16,034 | Mickey Lolich | Nelson Briles | Mickey Lolich | Nelson Briles | | 433 | 521 | -88 |
| 1974-08-13 | vs KCA | 117 | L 2-6 | 55-62 | 5 | 12,510 | Joe Coleman | Al Fitzmorris | Al Fitzmorris | Joe Coleman | | 435 | 527 | -92 |
| 1974-08-14 | vs KCA | 118 | L 1-9 | 55-63 | 6 | 13,504 | Fred Holdsworth | Steve Busby | Steve Busby | Fred Holdsworth | | 436 | 536 | -100 |
| 1974-08-16 | @ OAK | 119 | W 5-3 | 56-63 | 5 | 6,813 | Mickey Lolich | Catfish Hunter | Mickey Lolich | Catfish Hunter | | 441 | 539 | -98 |
| 1974-08-17 | @ OAK | 120 | W 4-3 | 57-63 | 5 | 10,600 | Lerrin LaGrow | Glenn Abbott | John Hiller | Glenn Abbott | | 445 | 542 | -97 |
| 1974-08-18 | @ OAK | 121 | L 3-13 | 57-64 | 6 | 9,327 | Joe Coleman | Ken Holtzman | Ken Holtzman | Joe Coleman | Rollie Fingers | 448 | 555 | -107 |
| 1974-08-19 | @ CAL | 122 | L 0-1 | 57-65 | 6 | 16,694 | Fred Holdsworth | Frank Tanana | Frank Tanana | Fred Holdsworth | | 448 | 556 | -108 |
| 1974-08-20 | @ CAL | 123 | W 1-0 | 58-65 | 6 | 12,433 | Mickey Lolich | Nolan Ryan | Mickey Lolich | Nolan Ryan | | 449 | 556 | -107 |
| 1974-08-21 | @ CAL | 124 | L 0-2 | 58-66 | 6 | 8,419 | Lerrin LaGrow | Andy Hassler | Andy Hassler | Lerrin LaGrow | | 449 | 558 | -109 |
| 1974-08-23 | vs TEX | 125 | L 2-5 | 58-67 | 6 | 20,020 | Joe Coleman | Steve Hargan | Steve Hargan | Joe Coleman | | 451 | 563 | -112 |
| 1974-08-24 | vs TEX | 126 | L 4-6 | 58-68 | 6 | 22,218 | Mickey Lolich | Jackie Brown | Steve Foucault | Mickey Lolich | | 455 | 569 | -114 |
| 1974-08-25 | vs TEX | 127 | W 6-5 | 59-68 | 6 | 16,256 | Fred Holdsworth | Jim Bibby | John Hiller | Steve Foucault | | 461 | 574 | -113 |
| 1974-08-26 | vs CAL | 128 | W 6-2 | 60-68 | 6 | 12,323 | Lerrin LaGrow | Andy Hassler | Lerrin LaGrow | Andy Hassler | | 467 | 576 | -109 |
| 1974-08-27 | vs CAL | 129 | L 6-7 | 60-69 | 6 | 8,479 | Joe Coleman | Skip Lockwood | Horacio Pina | John Hiller | | 473 | 583 | -110 |
| 1974-08-28 | vs CAL | 130 | W 2-1 | 61-69 | 6 | 9,513 | Mickey Lolich | Frank Tanana | Mickey Lolich | Frank Tanana | | 475 | 584 | -109 |
| 1974-08-30 | vs OAK | 131 | L 5-10 | 61-70 | 6 | 18,010 | Lerrin LaGrow | Ken Holtzman | Ken Holtzman | Lerrin LaGrow | Blue Moon Odom | 480 | 594 | -114 |
| 1974-08-31 | vs OAK | 132 | W 7-3 | 62-70 | 6 | 22,247 | Joe Coleman | Vida Blue | Joe Coleman | Vida Blue | | 487 | 597 | -110 |
| 1974-09-01 | vs OAK | 133 | L 3-5 | 62-71 | 6 | 17,235 | Mickey Lolich | Catfish Hunter | Catfish Hunter | Mickey Lolich | Rollie Fingers | 490 | 602 | -112 |
| 1974-09-03 | vs CLE | 134 | L 1-5 | 63-72 | 6 | 0 | Fred Holdsworth | Gaylord Perry | Gaylord Perry | Fred Holdsworth | | 491 | 607 | -116 |
| 1974-09-03 | vs CLE | 135 | W 5-4 | 63-72 | 6 | 7,050 | Lerrin LaGrow | Dick Bosman | John Hiller | Tom Buskey | | 496 | 611 | -115 |
| 1974-09-04 | vs CLE | 136 | L 4-5 | 63-73 | 6 | 6,513 | Joe Coleman | Jim Perry | Tom Buskey | John Hiller | | 500 | 616 | -116 |
| 1974-09-06 | @ NYA | 137 | L 2-6 | 63-74 | 6 | 20,712 | Mickey Lolich | Pat Dobson | Pat Dobson | Mickey Lolich | | 502 | 622 | -120 |
| 1974-09-07 | @ NYA | 138 | W 8-3 | 64-75 | 6 | 0 | Luke Walker | Rudy May | Luke Walker | Rudy May | John Hiller | 510 | 625 | -115 |
| 1974-09-07 | @ NYA | 139 | L 0-1 | 64-75 | 6 | 25,586 | Woodie Fryman | Larry Gura | Larry Gura | Woodie Fryman | | 510 | 626 | -116 |
| 1974-09-08 | @ NYA | 140 | W 11-3 | 65-75 | 6 | 24,216 | Joe Coleman | Dick Tidrow | Joe Coleman | Dick Tidrow | | 521 | 629 | -108 |
| 1974-09-09 | @ CLE | 141 | L 1-7 | 65-76 | 6 | 4,152 | Lerrin LaGrow | Dick Bosman | Dick Bosman | Lerrin LaGrow | | 522 | 636 | -114 |
| 1974-09-10 | @ CLE | 142 | L 6-12 | 65-77 | 6 | 3,570 | Mickey Lolich | Fritz Peterson | Fritz Peterson | Mickey Lolich | | 528 | 648 | -120 |
| 1974-09-11 | vs MIL | 143 | L 0-3 | 65-78 | 6 | 5,896 | Luke Walker | Jim Slaton | Jim Slaton | Luke Walker | | 528 | 651 | -123 |
| 1974-09-12 | vs MIL | 144 | W 9-7 | 66-78 | 6 | 5,806 | Joe Coleman | Jim Colborn | John Hiller | Tom Murphy | | 537 | 658 | -121 |
| 1974-09-13 | vs NYA | 145 | W 6-3 | 67-78 | 6 | 10,963 | Woodie Fryman | Doc Medich | Woodie Fryman | Doc Medich | | 543 | 661 | -118 |
| 1974-09-14 | vs NYA | 146 | L 7-10 | 67-79 | 6 | 12,662 | Mickey Lolich | Pat Dobson | Dick Tidrow | John Hiller | | 550 | 671 | -121 |
| 1974-09-15 | vs NYA | 147 | L 2-10 | 67-80 | 6 | 11,849 | Luke Walker | Larry Gura | Larry Gura | Luke Walker | | 552 | 681 | -129 |
| 1974-09-17 | @ BOS | 148 | W 5-3 | 68-80 | 6 | 12,213 | Joe Coleman | Bill Lee | Joe Coleman | Bill Lee | John Hiller | 557 | 684 | -127 |
| 1974-09-18 | @ BOS | 149 | L 5-8 | 68-81 | 6 | 12,213 | Lerrin LaGrow | Juan Marichal | Reggie Cleveland | Lerrin LaGrow | | 562 | 692 | -130 |
| 1974-09-19 | @ BOS | 150 | W 3-1 | 69-81 | 6 | 12,290 | Vern Ruhle | Luis Tiant | Vern Ruhle | Luis Tiant | | 565 | 693 | -128 |
| 1974-09-20 | @ MIL | 151 | W 8-5 | 70-81 | 6 | 7,249 | Woodie Fryman | Bill Champion | Dave Lemanczyk | Tom Murphy | | 573 | 698 | -125 |
| 1974-09-21 | @ MIL | 152 | L 2-6 | 70-82 | 6 | 6,714 | Mickey Lolich | Jim Slaton | Jim Slaton | Mickey Lolich | | 575 | 704 | -129 |
| 1974-09-22 | @ MIL | 153 | W 6-5 | 71-82 | 6 | 5,126 | Joe Coleman | Clyde Wright | Joe Coleman | Clyde Wright | John Hiller | 581 | 709 | -128 |
| 1974-09-24 | @ BAL | 154 | L 4-5 | 71-83 | 6 | 11,492 | Vern Ruhle | Dave McNally | Bob Reynolds | John Hiller | | 585 | 714 | -129 |
| 1974-09-25 | @ BAL | 155 | L 4-5 | 71-84 | 6 | 10,542 | Mickey Lolich | Ross Grimsley | Wayne Garland | Mickey Lolich | | 589 | 719 | -130 |
| 1974-09-26 | vs BOS | 156 | L 3-5 | 71-85 | 6 | 7,636 | Joe Coleman | Dick Drago | Dick Drago | John Hiller | | 592 | 724 | -132 |
| 1974-09-27 | vs BOS | 157 | L 3-9 | 71-86 | 6 | 8,177 | Woodie Fryman | Reggie Cleveland | Reggie Cleveland | Woodie Fryman | | 595 | 733 | -138 |
| 1974-09-28 | vs BOS | 158 | L 2-7 | 71-87 | 6 | 10,035 | Lerrin LaGrow | Luis Tiant | Luis Tiant | Lerrin LaGrow | Dick Pole | 597 | 740 | -143 |
| 1974-09-29 | vs BOS | 159 | W 7-4 | 72-87 | 6 | 21,178 | Vern Ruhle | Roger Moret | Vern Ruhle | Roger Moret | | 604 | 744 | -140 |
| 1974-09-30 | vs BAL | 160 | L 6-12 | 72-88 | 6 | 6,575 | Mickey Lolich | Ross Grimsley | Grant Jackson | Mickey Lolich | | 610 | 756 | -146 |
| 1974-10-01 | vs BAL | 161 | L 6-7 | 72-89 | 6 | 3,673 | Joe Coleman | Jim Palmer | Grant Jackson | John Hiller | Bob Reynolds | 616 | 763 | -147 |
| 1974-10-02 | vs BAL | 162 | L 4-5 | 72-90 | 6 | 4,671 | Lerrin LaGrow | Mike Cuellar | Doyle Alexander | Lerrin LaGrow | Don Hood | 620 | 768 | -148 |