| 1973-04-07 | vs DET | 1 | W 2-1 | 1-0 | 3 | 74,420 | Gaylord Perry | Mickey Lolich | Gaylord Perry | Mickey Lolich | | 2 | 1 | 1 |
| 1973-04-08 | vs DET | 2 | L 0-4 | 1-1 | 3 | 10,798 | Dick Tidrow | Joe Coleman | Joe Coleman | Dick Tidrow | Lerrin LaGrow | 2 | 5 | -3 |
| 1973-04-09 | @ NYA | 3 | W 3-1 | 2-1 | 3 | 17,028 | Brent Strom | Fritz Peterson | Brent Strom | Fritz Peterson | | 5 | 6 | -1 |
| 1973-04-11 | @ NYA | 4 | L 0-4 | 2-2 | 3 | 5,059 | Gaylord Perry | Mel Stottlemyre | Mel Stottlemyre | Gaylord Perry | | 5 | 10 | -5 |
| 1973-04-12 | @ NYA | 5 | L 0-5 | 2-3 | 3 | 4,532 | Dick Tidrow | Steve Kline | Steve Kline | Dick Tidrow | | 5 | 15 | -10 |
| 1973-04-13 | @ DET | 6 | L 3-4 | 2-4 | 4 | 5,009 | Brent Strom | Joe Coleman | Joe Coleman | Ed Farmer | | 8 | 19 | -11 |
| 1973-04-14 | @ DET | 7 | L 2-8 | 2-5 | 4 | 11,908 | Steve Dunning | Jim Perry | Jim Perry | Steve Dunning | | 10 | 27 | -17 |
| 1973-04-15 | @ DET | 8 | W 7-0 | 3-5 | 4 | 16,726 | Gaylord Perry | Tom Timmermann | Gaylord Perry | Tom Timmermann | | 17 | 27 | -10 |
| 1973-04-17 | vs MIL | 9 | W 7-3 | 4-5 | 4 | 3,224 | Dick Tidrow | Bill Parsons | Dick Tidrow | Bill Parsons | Ray Lamb | 24 | 30 | -6 |
| 1973-04-18 | vs MIL | 10 | L 0-4 | 4-6 | 4 | 3,539 | Brent Strom | Skip Lockwood | Skip Lockwood | Brent Strom | Jim Colborn | 24 | 34 | -10 |
| 1973-04-19 | vs MIL | 11 | L 7-10 | 4-7 | 6 | 3,296 | Steve Dunning | Jerry Bell | Ray Newman | Ed Farmer | | 31 | 44 | -13 |
| 1973-04-20 | vs BOS | 12 | W 3-2 | 5-7 | 4 | 12,185 | Gaylord Perry | Marty Pattin | Gaylord Perry | Marty Pattin | | 34 | 46 | -12 |
| 1973-04-21 | vs BOS | 13 | L 5-11 | 5-8 | 6 | 9,202 | Dick Tidrow | Lynn McGlothen | Lynn McGlothen | Dick Tidrow | Bill Lee | 39 | 57 | -18 |
| 1973-04-22 | vs BOS | 14 | W 8-7 | 6-9 | 5 | 0 | Brent Strom | Luis Tiant | Jerry Johnson | Sonny Siebert | | 47 | 64 | -17 |
| 1973-04-22 | vs BOS | 15 | L 2-5 | 6-9 | 5 | 8,145 | Steve Dunning | Roger Moret | Roger Moret | Steve Dunning | Bob Veale | 49 | 69 | -20 |
| 1973-04-24 | @ OAK | 16 | L 0-4 | 6-10 | 6 | 4,119 | Gaylord Perry | Ken Holtzman | Ken Holtzman | Gaylord Perry | Horacio Pina | 49 | 73 | -24 |
| 1973-04-25 | @ OAK | 17 | W 1-0 | 7-10 | 5 | 3,274 | Dick Tidrow | Rollie Fingers | Dick Tidrow | Rollie Fingers | | 50 | 73 | -23 |
| 1973-04-26 | @ OAK | 18 | L 2-3 | 7-11 | 5 | 3,146 | Brent Strom | Catfish Hunter | Darold Knowles | Jerry Johnson | | 52 | 76 | -24 |
| 1973-04-27 | @ CAL | 19 | W 6-2 | 8-11 | 5 | 32,321 | Milt Wilcox | Nolan Ryan | Milt Wilcox | Nolan Ryan | | 58 | 78 | -20 |
| 1973-04-28 | @ CAL | 20 | L 0-5 | 8-12 | 6 | 8,732 | Gaylord Perry | Rudy May | Rudy May | Gaylord Perry | | 58 | 83 | -25 |
| 1973-04-29 | @ CAL | 21 | W 3-2 | 9-12 | 5 | 13,244 | Dick Tidrow | Clyde Wright | Dick Tidrow | Clyde Wright | | 61 | 85 | -24 |
| 1973-05-02 | @ MIN | 22 | W 8-4 | 10-12 | 4 | 4,756 | Brent Strom | Dick Woodson | Ray Lamb | Ken Sanders | Jerry Johnson | 69 | 89 | -20 |
| 1973-05-04 | vs OAK | 23 | L 4-11 | 10-13 | 5 | 11,624 | Gaylord Perry | Catfish Hunter | Catfish Hunter | Gaylord Perry | | 73 | 100 | -27 |
| 1973-05-05 | vs OAK | 24 | W 6-5 | 11-13 | 2 | 4,918 | Milt Wilcox | Blue Moon Odom | Jerry Johnson | Darold Knowles | Ed Farmer | 79 | 105 | -26 |
| 1973-05-06 | vs OAK | 25 | L 0-12 | 11-15 | 4 | 0 | Dick Tidrow | Ken Holtzman | Ken Holtzman | Dick Tidrow | | 79 | 117 | -38 |
| 1973-05-06 | vs OAK | 26 | L 3-7 | 11-15 | 4 | 18,062 | Brent Strom | Vida Blue | Vida Blue | Brent Strom | | 82 | 124 | -42 |
| 1973-05-08 | vs CAL | 27 | W 2-0 | 12-15 | 4 | 1,437 | Gaylord Perry | Clyde Wright | Gaylord Perry | Clyde Wright | | 84 | 124 | -40 |
| 1973-05-09 | vs CAL | 28 | W 10-3 | 13-15 | 3 | 2,536 | Milt Wilcox | Rudy May | Milt Wilcox | Rudy May | Jerry Johnson | 94 | 127 | -33 |
| 1973-05-10 | @ BOS | 29 | L 3-4 | 13-16 | 5 | 8,640 | Dick Tidrow | Bill Lee | Bill Lee | Jerry Johnson | | 97 | 131 | -34 |
| 1973-05-11 | @ BOS | 30 | L 2-4 | 13-17 | 6 | 12,803 | Brent Strom | Luis Tiant | Luis Tiant | Brent Strom | | 99 | 135 | -36 |
| 1973-05-12 | @ BOS | 31 | W 10-2 | 14-17 | 5 | 15,510 | Gaylord Perry | John Curtis | Gaylord Perry | John Curtis | | 109 | 137 | -28 |
| 1973-05-13 | @ BOS | 32 | L 3-8 | 14-18 | 6 | 13,711 | Milt Wilcox | Marty Pattin | Marty Pattin | Ray Lamb | | 112 | 145 | -33 |
| 1973-05-14 | @ MIL | 33 | W 2-1 | 15-18 | 4 | 5,615 | Dick Tidrow | Bill Champion | Dick Tidrow | Bill Champion | Jerry Johnson | 114 | 146 | -32 |
| 1973-05-15 | @ MIL | 34 | L 1-2 | 15-19 | 6 | 7,864 | Dick Bosman | Jerry Bell | Skip Lockwood | Brent Strom | | 115 | 148 | -33 |
| 1973-05-17 | vs BAL | 35 | L 1-4 | 15-20 | 6 | 3,196 | Gaylord Perry | Jim Palmer | Jim Palmer | Gaylord Perry | | 116 | 152 | -36 |
| 1973-05-18 | vs BAL | 36 | L 2-6 | 15-21 | 6 | 6,064 | Dick Tidrow | Mike Cuellar | Orlando Pena | Dick Tidrow | | 118 | 158 | -40 |
| 1973-05-19 | vs NYA | 37 | W 6-4 | 16-21 | 5 | 6,337 | Milt Wilcox | Fritz Peterson | Milt Wilcox | Fritz Peterson | Ray Lamb | 124 | 162 | -38 |
| 1973-05-20 | vs NYA | 38 | L 2-4 | 16-23 | 6 | 0 | Dick Bosman | Fred Beene | Fred Beene | Dick Bosman | Sparky Lyle | 126 | 166 | -40 |
| 1973-05-20 | vs NYA | 39 | L 3-7 | 16-23 | 6 | 31,482 | Brent Strom | Mike Kekich | Mike Kekich | Brent Strom | Sparky Lyle | 129 | 173 | -44 |
| 1973-05-21 | vs NYA | 40 | W 10-5 | 17-23 | 6 | 4,168 | Gaylord Perry | Doc Medich | Gaylord Perry | Jim Magnuson | | 139 | 178 | -39 |
| 1973-05-22 | @ BAL | 41 | W 5-3 | 18-23 | 5 | 5,404 | Dick Tidrow | Dave McNally | Tom Hilgendorf | Dave McNally | Jerry Johnson | 144 | 181 | -37 |
| 1973-05-25 | @ CHA | 42 | W 8-3 | 19-23 | 5 | 17,680 | Dick Bosman | Rich Gossage | Ray Lamb | Rich Gossage | | 152 | 184 | -32 |
| 1973-05-26 | @ CHA | 43 | L 3-6 | 19-24 | 6 | 19,486 | Gaylord Perry | Stan Bahnsen | Wilbur Wood | Milt Wilcox | | 155 | 190 | -35 |
| 1973-05-28 | @ CHA | 44 | L 0-4 | 19-25 | 6 | 17,419 | Dick Tidrow | Wilbur Wood | Wilbur Wood | Dick Tidrow | | 155 | 194 | -39 |
| 1973-05-29 | @ TEX | 45 | W 9-7 | 20-25 | 5 | 4,676 | Dick Bosman | Lloyd Allen | Tom Hilgendorf | Lloyd Allen | Jerry Johnson | 164 | 201 | -37 |
| 1973-05-30 | @ TEX | 46 | L 2-3 | 20-26 | 5 | 5,128 | Gaylord Perry | Pete Broberg | Pete Broberg | Gaylord Perry | | 166 | 204 | -38 |
| 1973-05-31 | @ TEX | 47 | L 5-9 | 20-27 | 5 | 5,571 | Brent Strom | Sonny Siebert | Sonny Siebert | Brent Strom | Bill Gogolewski | 171 | 213 | -42 |
| 1973-06-01 | @ KCA | 48 | L 4-5 | 20-28 | 6 | 9,629 | Dick Tidrow | Dick Drago | Dick Drago | Tom Hilgendorf | | 175 | 218 | -43 |
| 1973-06-02 | @ KCA | 49 | L 1-5 | 20-29 | 6 | 14,919 | Milt Wilcox | Paul Splittorff | Paul Splittorff | Milt Wilcox | Doug Bird | 176 | 223 | -47 |
| 1973-06-03 | @ KCA | 50 | L 4-5 | 20-30 | 6 | 14,251 | Gaylord Perry | Steve Busby | Bruce Dal Canton | Ray Lamb | | 180 | 228 | -48 |
| 1973-06-06 | vs MIN | 51 | L 3-7 | 20-32 | 6 | 0 | Dick Tidrow | Jim Kaat | Ray Corbin | Jerry Johnson | | 183 | 235 | -52 |
| 1973-06-06 | vs MIN | 52 | L 9-13 | 20-32 | 6 | 2,033 | Ray Lamb | Joe Decker | Joe Decker | Ray Lamb | Dave Goltz | 192 | 248 | -56 |
| 1973-06-08 | vs CHA | 53 | L 2-5 | 20-33 | 6 | 9,595 | Milt Wilcox | Wilbur Wood | Wilbur Wood | Milt Wilcox | | 194 | 253 | -59 |
| 1973-06-09 | vs CHA | 54 | L 3-6 | 20-34 | 6 | 17,736 | Gaylord Perry | Eddie Fisher | Eddie Fisher | Gaylord Perry | Terry Forster | 197 | 259 | -62 |
| 1973-06-10 | vs CHA | 55 | L 3-5 | 21-35 | 6 | 0 | Dick Tidrow | Steve Stone | Steve Stone | Jerry Johnson | Terry Forster | 200 | 264 | -64 |
| 1973-06-10 | vs CHA | 56 | W 6-5 | 21-35 | 6 | 15,606 | Dick Bosman | Eddie Fisher | Tom Hilgendorf | Cy Acosta | | 206 | 269 | -63 |
| 1973-06-12 | vs TEX | 57 | W 5-4 | 22-35 | 6 | 2,105 | Milt Wilcox | Jim Merritt | Milt Wilcox | Jim Merritt | Tom Hilgendorf | 211 | 273 | -62 |
| 1973-06-13 | vs TEX | 58 | L 2-4 | 22-36 | 6 | 3,673 | Gaylord Perry | Pete Broberg | Pete Broberg | Gaylord Perry | Don Stanhouse | 213 | 277 | -64 |
| 1973-06-15 | vs KCA | 59 | L 2-7 | 22-37 | 6 | 7,654 | Dick Tidrow | Paul Splittorff | Paul Splittorff | Dick Tidrow | | 215 | 284 | -69 |
| 1973-06-16 | vs KCA | 60 | L 2-5 | 22-38 | 6 | 5,726 | Dick Bosman | Steve Busby | Gene Garber | Tom Hilgendorf | | 217 | 289 | -72 |
| 1973-06-17 | vs KCA | 61 | L 3-6 | 22-40 | 6 | 0 | Gaylord Perry | Dick Drago | Dick Drago | Gaylord Perry | | 220 | 295 | -75 |
| 1973-06-17 | vs KCA | 62 | L 2-6 | 22-40 | 6 | 11,943 | Mike Kekich | Ken Wright | Ken Wright | Mike Kekich | Gene Garber | 222 | 301 | -79 |
| 1973-06-18 | vs DET | 63 | L 1-5 | 22-41 | 6 | 20,011 | Brent Strom | Jim Perry | Jim Perry | Brent Strom | | 223 | 306 | -83 |
| 1973-06-19 | vs DET | 64 | W 8-7 | 23-41 | 6 | 3,485 | Dick Tidrow | Woodie Fryman | Jerry Johnson | Fred Scherman | | 231 | 313 | -82 |
| 1973-06-20 | vs DET | 65 | W 7-6 | 24-41 | 6 | 4,637 | Dick Bosman | Joe Coleman | Tom Timmermann | Mike Strahler | | 238 | 319 | -81 |
| 1973-06-21 | @ MIL | 66 | W 9-1 | 25-41 | 6 | 14,045 | Gaylord Perry | Jerry Bell | Gaylord Perry | Jerry Bell | | 247 | 320 | -73 |
| 1973-06-22 | @ MIL | 67 | L 2-8 | 25-42 | 6 | 36,438 | Mike Kekich | Jim Colborn | Jim Colborn | Mike Kekich | | 249 | 328 | -79 |
| 1973-06-23 | @ MIL | 68 | L 3-12 | 25-43 | 6 | 17,681 | Dick Tidrow | Jim Slaton | Jim Slaton | Dick Tidrow | | 252 | 340 | -88 |
| 1973-06-24 | @ MIL | 69 | L 3-8 | 25-44 | 6 | 34,442 | Dick Bosman | Bill Parsons | Chris Short | Dick Bosman | Frank Linzy | 255 | 348 | -93 |
| 1973-06-25 | vs NYA | 70 | W 4-2 | 26-44 | 6 | 18,670 | Gaylord Perry | Mel Stottlemyre | Gaylord Perry | Mel Stottlemyre | | 259 | 350 | -91 |
| 1973-06-26 | vs NYA | 71 | L 2-10 | 26-45 | 6 | 7,926 | Brent Strom | Pat Dobson | Pat Dobson | Brent Strom | Lindy McDaniel | 261 | 360 | -99 |
| 1973-06-28 | @ BOS | 72 | W 4-2 | 27-46 | 6 | 0 | Dick Tidrow | Ray Culp | Dick Tidrow | Ray Culp | Tom Timmermann | 265 | 362 | -97 |
| 1973-06-28 | @ BOS | 73 | L 7-16 | 27-46 | 6 | 15,139 | Dick Bosman | Marty Pattin | Marty Pattin | Dick Bosman | Roger Moret | 272 | 378 | -106 |
| 1973-06-29 | @ NYA | 74 | L 2-7 | 27-47 | 6 | 9,611 | Gaylord Perry | Doc Medich | Doc Medich | Gaylord Perry | | 274 | 385 | -111 |
| 1973-06-30 | @ NYA | 75 | L 3-7 | 27-48 | 6 | 11,086 | Brent Strom | Mel Stottlemyre | Mel Stottlemyre | Brent Strom | | 277 | 392 | -115 |
| 1973-07-01 | @ NYA | 76 | L 2-5 | 27-50 | 6 | 0 | Tom Hilgendorf | Pat Dobson | Pat Dobson | Tom Hilgendorf | Sparky Lyle | 279 | 397 | -118 |
| 1973-07-01 | @ NYA | 77 | L 3-11 | 27-50 | 6 | 28,556 | Tom Timmermann | Dave Pagan | Fred Beene | Tom Timmermann | | 282 | 408 | -126 |
| 1973-07-02 | vs DET | 78 | L 3-4 | 27-51 | 6 | 4,989 | Dick Tidrow | Woodie Fryman | Ed Farmer | Dick Tidrow | John Hiller | 285 | 412 | -127 |
| 1973-07-03 | vs DET | 79 | L 4-5 | 27-52 | 6 | 9,064 | Gaylord Perry | Jim Perry | Ed Farmer | Gaylord Perry | John Hiller | 289 | 417 | -128 |
| 1973-07-04 | @ DET | 80 | W 5-2 | 28-52 | 6 | 26,012 | Milt Wilcox | Mike Strahler | Milt Wilcox | Mike Strahler | Tom Hilgendorf | 294 | 419 | -125 |
| 1973-07-05 | @ DET | 81 | L 5-7 | 28-53 | 6 | 17,891 | Brent Strom | Mickey Lolich | Bob Miller | Tom Timmermann | | 299 | 426 | -127 |
| 1973-07-06 | vs CAL | 82 | W 8-7 | 29-53 | 6 | 6,699 | Dick Tidrow | Clyde Wright | Jerry Johnson | Steve Barber | | 307 | 433 | -126 |
| 1973-07-07 | vs CAL | 83 | L 1-3 | 29-54 | 6 | 7,553 | Gaylord Perry | Nolan Ryan | Nolan Ryan | Gaylord Perry | Steve Barber | 308 | 436 | -128 |
| 1973-07-08 | vs CAL | 84 | L 4-10 | 29-56 | 6 | 0 | Milt Wilcox | Bill Singer | Bill Singer | Milt Wilcox | | 312 | 446 | -134 |
| 1973-07-08 | vs CAL | 85 | L 3-5 | 29-56 | 6 | 12,147 | Dick Bosman | Dick Lange | Steve Barber | Jerry Johnson | Dave Sells | 315 | 451 | -136 |
| 1973-07-10 | vs OAK | 86 | W 7-5 | 30-56 | 6 | 6,388 | Dick Tidrow | Blue Moon Odom | Dick Tidrow | Darold Knowles | | 322 | 456 | -134 |
| 1973-07-11 | vs OAK | 87 | L 3-9 | 30-57 | 6 | 8,627 | Gaylord Perry | Catfish Hunter | Catfish Hunter | Gaylord Perry | | 325 | 465 | -140 |
| 1973-07-12 | @ MIN | 88 | L 4-8 | 31-58 | 6 | 0 | Milt Wilcox | Dick Woodson | Dave Goltz | Milt Wilcox | Ray Corbin | 329 | 473 | -144 |
| 1973-07-12 | @ MIN | 89 | W 7-4 | 31-58 | 6 | 11,054 | Brent Strom | Eddie Bane | Jerry Johnson | Ken Sanders | | 336 | 477 | -141 |
| 1973-07-13 | @ MIN | 90 | W 11-2 | 32-58 | 6 | 12,233 | Dick Bosman | Joe Decker | Dick Bosman | Joe Decker | | 347 | 479 | -132 |
| 1973-07-14 | @ MIN | 91 | W 3-0 | 33-58 | 6 | 15,427 | Dick Tidrow | Jim Kaat | Dick Tidrow | Jim Kaat | | 350 | 479 | -129 |
| 1973-07-15 | @ MIN | 92 | L 6-7 | 33-59 | 6 | 15,256 | Gaylord Perry | Bert Blyleven | Ray Corbin | Jerry Johnson | | 356 | 486 | -130 |
| 1973-07-16 | @ CAL | 93 | W 9-8 | 34-59 | 6 | 20,265 | Milt Wilcox | Bill Singer | Milt Wilcox | Bill Singer | Tom Timmermann | 365 | 494 | -129 |
| 1973-07-17 | @ CAL | 94 | L 1-3 | 34-60 | 6 | 10,968 | Dick Bosman | Clyde Wright | Clyde Wright | Dick Bosman | | 366 | 497 | -131 |
| 1973-07-18 | @ CAL | 95 | W 10-8 | 35-60 | 6 | 10,005 | Dick Tidrow | Rudy May | Tom Hilgendorf | Steve Barber | | 376 | 505 | -129 |
| 1973-07-20 | @ OAK | 96 | L 5-6 | 35-61 | 6 | 9,236 | Gaylord Perry | Catfish Hunter | Catfish Hunter | Gaylord Perry | | 381 | 511 | -130 |
| 1973-07-21 | @ OAK | 97 | L 2-5 | 35-62 | 6 | 20,275 | Milt Wilcox | Vida Blue | Vida Blue | Milt Wilcox | | 383 | 516 | -133 |
| 1973-07-22 | @ OAK | 98 | L 2-5 | 35-63 | 6 | 10,628 | Dick Bosman | Ken Holtzman | Ken Holtzman | Dick Bosman | | 385 | 521 | -136 |
| 1973-07-26 | @ BAL | 99 | L 4-8 | 36-64 | 6 | 0 | Gaylord Perry | Dave McNally | Don Hood | Gaylord Perry | | 389 | 529 | -140 |
| 1973-07-26 | @ BAL | 100 | W 6-4 | 36-64 | 6 | 11,063 | Dick Tidrow | Mike Cuellar | Dick Tidrow | Mike Cuellar | Tom Hilgendorf | 395 | 533 | -138 |
| 1973-07-27 | @ BAL | 101 | L 0-9 | 36-66 | 6 | 0 | Dick Bosman | Jim Palmer | Jim Palmer | Dick Bosman | | 395 | 542 | -147 |
| 1973-07-27 | @ BAL | 102 | L 2-5 | 36-66 | 6 | 10,857 | Brent Strom | Jesse Jefferson | Bob Reynolds | Brent Strom | | 397 | 547 | -150 |
| 1973-07-28 | vs BOS | 103 | L 4-7 | 36-67 | 6 | 7,865 | Mike Kekich | John Curtis | John Curtis | Mike Kekich | Roger Moret | 401 | 554 | -153 |
| 1973-07-29 | vs BOS | 104 | W 8-2 | 38-67 | 6 | 0 | Gaylord Perry | Marty Pattin | Gaylord Perry | Marty Pattin | | 409 | 556 | -147 |
| 1973-07-29 | vs BOS | 105 | W 6-2 | 38-67 | 6 | 26,858 | Tom Timmermann | Ray Culp | Tom Timmermann | Ray Culp | | 415 | 558 | -143 |
| 1973-07-31 | vs BAL | 106 | L 1-5 | 38-68 | 6 | 17,912 | Dick Tidrow | Jim Palmer | Jim Palmer | Dick Tidrow | | 416 | 563 | -147 |
| 1973-08-01 | vs BAL | 107 | L 2-4 | 38-69 | 6 | 3,564 | Dick Bosman | Mike Cuellar | Mike Cuellar | Dick Bosman | Bob Reynolds | 418 | 567 | -149 |
| 1973-08-02 | vs BAL | 108 | W 6-0 | 39-69 | 6 | 3,980 | Gaylord Perry | Don Hood | Gaylord Perry | Don Hood | | 424 | 567 | -143 |
| 1973-08-03 | vs MIL | 109 | W 9-4 | 40-69 | 6 | 6,070 | Tom Timmermann | Bill Parsons | Tom Timmermann | Carlos Velazquez | Tom Hilgendorf | 433 | 571 | -138 |
| 1973-08-04 | vs MIL | 110 | L 4-9 | 40-70 | 6 | 6,589 | Dick Tidrow | Jim Colborn | Jim Colborn | Dick Tidrow | | 437 | 580 | -143 |
| 1973-08-05 | vs MIL | 111 | W 6-5 | 42-70 | 6 | 0 | Dick Bosman | Jim Slaton | Ken Sanders | Eduardo Rodriguez | | 443 | 585 | -142 |
| 1973-08-05 | vs MIL | 112 | W 4-1 | 42-70 | 6 | 12,947 | Brent Strom | Skip Lockwood | Brent Strom | Skip Lockwood | | 447 | 586 | -139 |
| 1973-08-06 | @ CHA | 113 | W 7-3 | 43-70 | 6 | 5,811 | Gaylord Perry | Steve Stone | Gaylord Perry | Steve Stone | | 454 | 589 | -135 |
| 1973-08-07 | @ CHA | 114 | L 5-6 | 43-71 | 6 | 12,375 | Tom Timmermann | Wilbur Wood | Cy Acosta | Ken Sanders | | 459 | 595 | -136 |
| 1973-08-08 | @ CHA | 115 | W 13-1 | 44-71 | 6 | 16,344 | Dick Tidrow | Stan Bahnsen | Dick Tidrow | Stan Bahnsen | | 472 | 596 | -124 |
| 1973-08-10 | @ TEX | 116 | W 8-1 | 45-71 | 6 | 28,326 | Gaylord Perry | David Clyde | Gaylord Perry | David Clyde | | 480 | 597 | -117 |
| 1973-08-11 | @ TEX | 117 | W 5-2 | 46-71 | 6 | 12,982 | Tom Timmermann | Jim Bibby | Tom Timmermann | Jim Bibby | Ken Sanders | 485 | 599 | -114 |
| 1973-08-12 | @ TEX | 118 | W 7-6 | 47-71 | 6 | 4,905 | Dick Tidrow | Jackie Brown | Ken Sanders | Bill Gogolewski | | 492 | 605 | -113 |
| 1973-08-14 | @ KCA | 119 | L 5-8 | 47-72 | 6 | 18,047 | Gaylord Perry | Steve Busby | Steve Busby | Gaylord Perry | Doug Bird | 497 | 613 | -116 |
| 1973-08-15 | @ KCA | 120 | L 1-5 | 47-73 | 6 | 16,268 | Tom Timmermann | Al Fitzmorris | Al Fitzmorris | Tom Timmermann | | 498 | 618 | -120 |
| 1973-08-16 | @ KCA | 121 | W 10-4 | 48-73 | 6 | 17,235 | Dick Tidrow | Paul Splittorff | Dick Tidrow | Paul Splittorff | | 508 | 622 | -114 |
| 1973-08-17 | vs MIN | 122 | L 2-14 | 48-74 | 6 | 8,051 | Dick Bosman | Bert Blyleven | Bert Blyleven | Dick Bosman | | 510 | 636 | -126 |
| 1973-08-18 | vs MIN | 123 | W 5-0 | 49-74 | 6 | 6,694 | Gaylord Perry | Dick Woodson | Gaylord Perry | Dick Woodson | | 515 | 636 | -121 |
| 1973-08-19 | vs MIN | 124 | W 5-3 | 51-74 | 6 | 0 | Tom Timmermann | Dave Goltz | Tom Timmermann | Dave Goltz | Ken Sanders | 520 | 639 | -119 |
| 1973-08-19 | vs MIN | 125 | W 4-3 | 51-74 | 6 | 13,146 | Jerry Johnson | Joe Decker | Ken Sanders | Eddie Bane | | 524 | 642 | -118 |
| 1973-08-21 | vs CHA | 126 | L 0-4 | 51-75 | 6 | 13,728 | Dick Tidrow | Stan Bahnsen | Stan Bahnsen | Dick Tidrow | | 524 | 646 | -122 |
| 1973-08-22 | vs CHA | 127 | W 1-0 | 52-75 | 6 | 5,004 | Gaylord Perry | Terry Forster | Gaylord Perry | Cy Acosta | | 525 | 646 | -121 |
| 1973-08-24 | vs TEX | 128 | W 11-5 | 53-75 | 6 | 5,736 | Tom Timmermann | Don Durham | Tom Timmermann | Don Durham | | 536 | 651 | -115 |
| 1973-08-25 | vs TEX | 129 | W 6-5 | 54-75 | 6 | 4,218 | Dick Tidrow | Jim Bibby | Ken Sanders | Jackie Brown | | 542 | 656 | -114 |
| 1973-08-26 | vs TEX | 130 | L 0-9 | 54-77 | 6 | 0 | Gaylord Perry | Jim Merritt | Jim Merritt | Gaylord Perry | | 542 | 665 | -123 |
| 1973-08-26 | vs TEX | 131 | L 3-5 | 54-77 | 6 | 12,563 | Milt Wilcox | Mike Paul | Mike Paul | Milt Wilcox | Sonny Siebert | 545 | 670 | -125 |
| 1973-08-28 | vs KCA | 132 | W 4-3 | 55-77 | 6 | 8,015 | Tom Timmermann | Dick Drago | Tom Timmermann | Dick Drago | Tom Hilgendorf | 549 | 673 | -124 |
| 1973-08-29 | vs KCA | 133 | L 2-3 | 55-78 | 6 | 3,471 | Dick Tidrow | Steve Busby | Steve Busby | Dick Tidrow | Doug Bird | 551 | 676 | -125 |
| 1973-08-30 | @ DET | 134 | W 3-0 | 56-78 | 6 | 12,681 | Gaylord Perry | Joe Coleman | Gaylord Perry | Joe Coleman | | 554 | 676 | -122 |
| 1973-08-31 | @ DET | 135 | W 6-3 | 57-78 | 6 | 18,442 | Mike Kekich | Mickey Lolich | Mike Kekich | Mickey Lolich | Tom Hilgendorf | 560 | 679 | -119 |
| 1973-09-01 | @ DET | 136 | W 5-4 | 58-78 | 6 | 18,819 | Tom Timmermann | Woodie Fryman | Tom Hilgendorf | John Hiller | Ken Sanders | 565 | 683 | -118 |
| 1973-09-02 | @ DET | 137 | L 1-2 | 58-79 | 6 | 17,265 | Dick Tidrow | Jim Perry | Jim Perry | Dick Tidrow | John Hiller | 566 | 685 | -119 |
| 1973-09-03 | @ MIL | 138 | L 5-13 | 59-80 | 6 | 0 | Gaylord Perry | Jim Slaton | Jim Slaton | Gaylord Perry | Eduardo Rodriguez | 571 | 698 | -127 |
| 1973-09-03 | @ MIL | 139 | W 10-5 | 59-80 | 6 | 12,994 | Milt Wilcox | Bill Parsons | Milt Wilcox | Bill Parsons | | 581 | 703 | -122 |
| 1973-09-04 | @ MIL | 140 | W 5-4 | 60-80 | 6 | 4,864 | Mike Kekich | Bill Champion | Ken Sanders | Bill Champion | | 586 | 707 | -121 |
| 1973-09-05 | vs DET | 141 | L 3-7 | 60-81 | 6 | 2,514 | Tom Timmermann | Lerrin LaGrow | Lerrin LaGrow | Tom Timmermann | Fred Scherman | 589 | 714 | -125 |
| 1973-09-06 | vs DET | 142 | W 10-4 | 61-81 | 6 | 2,871 | Dick Tidrow | Woodie Fryman | Dick Tidrow | Woodie Fryman | | 599 | 718 | -119 |
| 1973-09-07 | vs BAL | 143 | L 3-7 | 61-82 | 6 | 5,160 | Gaylord Perry | Dave McNally | Dave McNally | Gaylord Perry | | 602 | 725 | -123 |
| 1973-09-08 | vs BAL | 144 | L 1-6 | 61-83 | 6 | 3,851 | Milt Wilcox | Jim Palmer | Jim Palmer | Milt Wilcox | | 603 | 731 | -128 |
| 1973-09-09 | vs BAL | 145 | W 6-4 | 62-84 | 6 | 0 | Brent Strom | Doyle Alexander | Ray Lamb | Doyle Alexander | | 609 | 735 | -126 |
| 1973-09-09 | vs BAL | 146 | L 4-13 | 62-84 | 6 | 7,120 | Tom Timmermann | Mike Cuellar | Mike Cuellar | Tom Timmermann | Eddie Watt | 613 | 748 | -135 |
| 1973-09-10 | @ NYA | 147 | W 3-2 | 63-84 | 6 | 5,015 | Dick Tidrow | Fritz Peterson | Dick Tidrow | Fritz Peterson | | 616 | 750 | -134 |
| 1973-09-11 | @ NYA | 148 | W 7-3 | 64-84 | 6 | 5,637 | Gaylord Perry | Pat Dobson | Gaylord Perry | Pat Dobson | | 623 | 753 | -130 |
| 1973-09-14 | @ BOS | 149 | L 4-6 | 64-85 | 6 | 11,606 | Tom Timmermann | Luis Tiant | Luis Tiant | Tom Timmermann | Bobby Bolin | 627 | 759 | -132 |
| 1973-09-15 | @ BOS | 150 | W 9-8 | 65-85 | 6 | 11,478 | Dick Tidrow | Marty Pattin | Dick Tidrow | Marty Pattin | Ken Sanders | 636 | 767 | -131 |
| 1973-09-16 | @ BOS | 151 | W 5-1 | 66-85 | 6 | 12,743 | Gaylord Perry | Roger Moret | Gaylord Perry | Roger Moret | | 641 | 768 | -127 |
| 1973-09-18 | vs MIL | 152 | W 6-5 | 67-85 | 6 | 1,546 | Milt Wilcox | Jim Colborn | Milt Wilcox | Chris Short | | 647 | 773 | -126 |
| 1973-09-19 | vs MIL | 153 | L 4-7 | 67-86 | 6 | 1,009 | Dick Tidrow | Jim Slaton | Jim Slaton | Dick Tidrow | Ed Sprague | 651 | 780 | -129 |
| 1973-09-22 | vs NYA | 154 | W 5-1 | 68-86 | 6 | 3,775 | Gaylord Perry | Pat Dobson | Gaylord Perry | Pat Dobson | | 656 | 781 | -125 |
| 1973-09-23 | vs NYA | 155 | L 1-9 | 68-88 | 6 | 0 | Dick Tidrow | Mel Stottlemyre | Mel Stottlemyre | Dick Tidrow | | 657 | 790 | -133 |
| 1973-09-23 | vs NYA | 156 | L 1-2 | 68-88 | 6 | 6,173 | Milt Wilcox | Doc Medich | Doc Medich | Milt Wilcox | Lindy McDaniel | 658 | 792 | -134 |
| 1973-09-25 | vs BOS | 157 | L 2-3 | 68-89 | 6 | 2,283 | Tom Timmermann | Roger Moret | Roger Moret | Tom Timmermann | Bobby Bolin | 660 | 795 | -135 |
| 1973-09-26 | vs BOS | 158 | W 1-0 | 69-89 | 6 | 1,453 | Gaylord Perry | Bill Lee | Gaylord Perry | Bill Lee | | 661 | 795 | -134 |
| 1973-09-28 | @ BAL | 159 | W 6-4 | 70-90 | 6 | 0 | Dick Tidrow | Jim Palmer | Dick Tidrow | Jim Palmer | Ken Sanders | 667 | 799 | -132 |
| 1973-09-28 | @ BAL | 160 | L 4-18 | 70-90 | 6 | 9,630 | Milt Wilcox | Doyle Alexander | Doyle Alexander | Milt Wilcox | Grant Jackson | 671 | 817 | -146 |
| 1973-09-29 | @ BAL | 161 | W 6-2 | 71-91 | 6 | 0 | Tom Timmermann | Dave McNally | Tom Timmermann | Dave McNally | | 677 | 819 | -142 |
| 1973-09-29 | @ BAL | 162 | L 3-7 | 71-91 | 6 | 6,598 | Mike Kekich | Mike Cuellar | Mike Cuellar | Mike Kekich | | 680 | 826 | -146 |