| 1973-04-05 | vs SFN | 1 | L 1-4 | 0-1 | 3 | 51,579 | Don Gullett | Juan Marichal | Juan Marichal | Don Gullett | | 1 | 4 | -3 |
| 1973-04-07 | vs SFN | 2 | L 5-7 | 0-2 | 5 | 10,464 | Jack Billingham | Jim Willoughby | Elias Sosa | Clay Carroll | | 6 | 11 | -5 |
| 1973-04-08 | vs SFN | 3 | W 3-1 | 1-2 | 5 | 20,026 | Ross Grimsley | Tom Bradley | Ross Grimsley | Tom Bradley | Pedro Borbon | 9 | 12 | -3 |
| 1973-04-09 | @ ATL | 4 | W 8-7 | 2-2 | 3 | 3,920 | Roger Nelson | Carl Morton | Tom Hall | Joe Hoerner | Pedro Borbon | 17 | 19 | -2 |
| 1973-04-11 | @ LAN | 5 | W 4-1 | 3-2 | 3 | 24,755 | Don Gullett | Don Sutton | Don Gullett | Don Sutton | Tom Hall | 21 | 20 | 1 |
| 1973-04-12 | @ LAN | 6 | W 5-2 | 4-2 | 2 | 14,056 | Jack Billingham | Andy Messersmith | Jack Billingham | Andy Messersmith | | 26 | 22 | 4 |
| 1973-04-13 | @ SFN | 7 | L 4-5 | 4-3 | 2 | 7,353 | Ross Grimsley | Ron Bryant | Elias Sosa | Tom Hall | Sam McDowell | 30 | 27 | 3 |
| 1973-04-14 | @ SFN | 8 | W 3-0 | 5-3 | 2 | 21,247 | Roger Nelson | Jim Barr | Roger Nelson | Jim Barr | Clay Carroll | 33 | 27 | 6 |
| 1973-04-15 | @ SFN | 9 | W 11-0 | 7-3 | 1 | 0 | Don Gullett | Juan Marichal | Don Gullett | Juan Marichal | | 44 | 27 | 17 |
| 1973-04-15 | @ SFN | 10 | W 7-3 | 7-3 | 1 | 27,651 | Jim McGlothlin | Jim Willoughby | Jim McGlothlin | Jim Willoughby | Clay Carroll | 51 | 30 | 21 |
| 1973-04-16 | @ SDN | 11 | W 7-6 | 8-3 | 1 | 9,189 | Jack Billingham | Clay Kirby | Jack Billingham | Clay Kirby | Clay Carroll | 58 | 36 | 22 |
| 1973-04-17 | @ SDN | 12 | W 3-0 | 9-3 | 1 | 7,976 | Ross Grimsley | Fred Norman | Ross Grimsley | Fred Norman | | 61 | 36 | 25 |
| 1973-04-18 | @ SDN | 13 | L 2-4 | 9-4 | 2 | 10,587 | Roger Nelson | Steve Arlin | Steve Arlin | Roger Nelson | Bill Greif | 63 | 40 | 23 |
| 1973-04-20 | vs ATL | 14 | W 4-2 | 10-4 | 2 | 42,035 | Don Gullett | Gary Gentry | Don Gullett | Gary Gentry | Tom Hall | 67 | 42 | 25 |
| 1973-04-21 | vs ATL | 15 | L 4-5 | 10-5 | 2 | 15,171 | Jack Billingham | Pat Dobson | Phil Niekro | Pedro Borbon | | 71 | 47 | 24 |
| 1973-04-22 | vs ATL | 16 | W 6-3 | 11-5 | 2 | 11,659 | Ross Grimsley | Ron Reed | Ross Grimsley | Ron Reed | | 77 | 50 | 27 |
| 1973-04-24 | vs MON | 17 | L 2-7 | 11-6 | 2 | 9,539 | Don Gullett | Mike Torrez | Mike Torrez | Clay Carroll | Tom Walker | 79 | 57 | 22 |
| 1973-04-25 | vs MON | 18 | W 7-4 | 12-6 | 2 | 8,149 | Jack Billingham | Balor Moore | Jack Billingham | Tom Walker | Pedro Borbon | 86 | 61 | 25 |
| 1973-04-27 | vs PHI | 19 | L 1-3 | 12-7 | 2 | 13,690 | Ross Grimsley | Steve Carlton | Steve Carlton | Ross Grimsley | | 87 | 64 | 23 |
| 1973-04-28 | vs PHI | 20 | L 0-1 | 12-8 | 2 | 14,126 | Don Gullett | Dick Ruthven | Dick Ruthven | Don Gullett | Mac Scarce | 87 | 65 | 22 |
| 1973-04-29 | vs PHI | 21 | W 8-0 | 13-8 | 2 | 39,191 | Jack Billingham | Larry Christenson | Jack Billingham | Larry Christenson | | 95 | 65 | 30 |
| 1973-05-02 | @ NYN | 22 | W 6-1 | 14-8 | 2 | 19,163 | Ross Grimsley | Tom Seaver | Ross Grimsley | Tom Seaver | Pedro Borbon | 101 | 66 | 35 |
| 1973-05-03 | @ NYN | 23 | W 6-5 | 15-8 | 2 | 9,163 | Jim McGlothlin | Jon Matlack | Tom Hall | Jon Matlack | | 107 | 71 | 36 |
| 1973-05-04 | @ MON | 24 | L 3-6 | 15-9 | 3 | 10,665 | Jack Billingham | Mike Torrez | Mike Torrez | Jack Billingham | Steve Renko | 110 | 77 | 33 |
| 1973-05-05 | @ MON | 25 | L 6-8 | 15-10 | 3 | 8,623 | Don Gullett | Bill Stoneman | Pat Jarvis | Clay Carroll | Joe Gilbert | 116 | 85 | 31 |
| 1973-05-06 | @ MON | 26 | W 6-1 | 16-10 | 3 | 10,258 | Roger Nelson | Balor Moore | Roger Nelson | Balor Moore | | 122 | 86 | 36 |
| 1973-05-07 | @ PHI | 27 | L 2-3 | 16-11 | 3 | 7,886 | Ross Grimsley | Wayne Twitchell | Barry Lersch | Pedro Borbon | | 124 | 89 | 35 |
| 1973-05-08 | @ PHI | 28 | W 7-1 | 17-11 | 3 | 6,196 | Jack Billingham | Dick Ruthven | Jack Billingham | Dick Ruthven | | 131 | 90 | 41 |
| 1973-05-09 | @ PHI | 29 | W 9-7 | 18-11 | 3 | 11,992 | Don Gullett | Steve Carlton | Tom Hall | Barry Lersch | | 140 | 97 | 43 |
| 1973-05-11 | @ HOU | 30 | L 1-5 | 18-12 | 3 | 31,354 | Roger Nelson | Don Wilson | Don Wilson | Roger Nelson | | 141 | 102 | 39 |
| 1973-05-12 | @ HOU | 31 | L 1-7 | 18-13 | 3 | 38,874 | Ross Grimsley | Jerry Reuss | Jerry Reuss | Ross Grimsley | Jim York | 142 | 109 | 33 |
| 1973-05-13 | @ HOU | 32 | W 2-0 | 19-13 | 3 | 27,905 | Jack Billingham | Ken Forsch | Jack Billingham | Ken Forsch | | 144 | 109 | 35 |
| 1973-05-15 | vs LAN | 33 | W 4-1 | 20-13 | 3 | 11,731 | Don Gullett | Claude Osteen | Don Gullett | Claude Osteen | Pedro Borbon | 148 | 110 | 38 |
| 1973-05-16 | vs LAN | 34 | L 6-8 | 20-14 | 3 | 10,120 | Ross Grimsley | Al Downing | Charlie Hough | Tom Hall | | 154 | 118 | 36 |
| 1973-05-17 | vs LAN | 35 | L 1-3 | 20-15 | 3 | 11,433 | Clay Carroll | Don Sutton | Don Sutton | Pedro Borbon | Pete Richert | 155 | 121 | 34 |
| 1973-05-18 | vs SDN | 36 | W 5-4 | 21-15 | 3 | 28,109 | Jack Billingham | Bill Greif | Jack Billingham | Bill Greif | | 160 | 125 | 35 |
| 1973-05-19 | vs SDN | 37 | W 10-4 | 22-15 | 3 | 18,839 | Jim McGlothlin | Mike Corkins | Jim McGlothlin | Mike Corkins | Ed Sprague | 170 | 129 | 41 |
| 1973-05-20 | vs SDN | 38 | L 1-2 | 23-16 | 3 | 0 | Ross Grimsley | Fred Norman | Fred Norman | Ross Grimsley | | 171 | 131 | 40 |
| 1973-05-20 | vs SDN | 39 | W 3-2 | 23-16 | 3 | 29,055 | Don Gullett | Mike Caldwell | Don Gullett | Mike Caldwell | Tom Hall | 174 | 133 | 41 |
| 1973-05-22 | vs HOU | 40 | W 6-4 | 24-16 | 3 | 11,741 | Clay Carroll | Dave Roberts | Clay Carroll | Dave Roberts | Pedro Borbon | 180 | 137 | 43 |
| 1973-05-23 | vs HOU | 41 | W 4-3 | 25-16 | 2 | 16,134 | Jack Billingham | Don Wilson | Tom Hall | Jim York | | 184 | 140 | 44 |
| 1973-05-25 | vs CHN | 42 | L 2-7 | 25-17 | 3 | 17,843 | Don Gullett | Rick Reuschel | Rick Reuschel | Don Gullett | Bob Locker | 186 | 147 | 39 |
| 1973-05-26 | vs CHN | 43 | L 0-2 | 25-18 | 3 | 24,402 | Ross Grimsley | Milt Pappas | Milt Pappas | Ross Grimsley | Jack Aker | 186 | 149 | 37 |
| 1973-05-27 | vs CHN | 44 | L 0-6 | 25-19 | 4 | 35,484 | Jim McGlothlin | Fergie Jenkins | Fergie Jenkins | Jim McGlothlin | | 186 | 155 | 31 |
| 1973-05-28 | vs CHN | 45 | W 6-5 | 26-19 | 4 | 15,453 | Jack Billingham | Burt Hooton | Tom Hall | Bob Locker | | 192 | 160 | 32 |
| 1973-05-29 | @ SLN | 46 | L 0-2 | 26-20 | 4 | 13,384 | Clay Carroll | Scipio Spinks | Scipio Spinks | Clay Carroll | Diego Segui | 192 | 162 | 30 |
| 1973-05-30 | @ SLN | 47 | L 2-5 | 26-21 | 4 | 11,612 | Don Gullett | Alan Foster | Rich Folkers | Ed Sprague | Wayne Granger | 194 | 167 | 27 |
| 1973-05-31 | @ SLN | 48 | W 3-2 | 27-21 | 4 | 14,192 | Ross Grimsley | Bob Gibson | Ross Grimsley | Bob Gibson | | 197 | 169 | 28 |
| 1973-06-01 | @ PIT | 49 | L 6-9 | 27-22 | 4 | 24,213 | Jim McGlothlin | Steve Blass | Steve Blass | Ed Sprague | Dave Giusti | 203 | 178 | 25 |
| 1973-06-02 | @ PIT | 50 | L 3-4 | 27-23 | 4 | 19,212 | Jack Billingham | Dock Ellis | Dock Ellis | Jack Billingham | Dave Giusti | 206 | 182 | 24 |
| 1973-06-03 | @ PIT | 51 | W 5-1 | 28-23 | 3 | 22,450 | Clay Carroll | Luke Walker | Clay Carroll | Luke Walker | Pedro Borbon | 211 | 183 | 28 |
| 1973-06-04 | vs NYN | 52 | W 5-0 | 29-23 | 3 | 13,145 | Jack Billingham | Jon Matlack | Jack Billingham | Jon Matlack | | 216 | 183 | 33 |
| 1973-06-05 | vs NYN | 53 | W 6-5 | 30-23 | 3 | 14,654 | Ross Grimsley | Jerry Koosman | Don Gullett | Phil Hennigan | | 222 | 188 | 34 |
| 1973-06-08 | @ CHN | 54 | L 5-6 | 30-24 | 3 | 17,678 | Clay Carroll | Milt Pappas | Jack Aker | Tom Hall | | 227 | 194 | 33 |
| 1973-06-09 | @ CHN | 55 | W 8-4 | 31-24 | 3 | 32,081 | Jack Billingham | Fergie Jenkins | Pedro Borbon | Larry Gura | Ross Grimsley | 235 | 198 | 37 |
| 1973-06-10 | @ CHN | 56 | L 7-9 | 31-25 | 3 | 34,247 | Jim McGlothlin | Burt Hooton | Bill Bonham | Jim McGlothlin | Bob Locker | 242 | 207 | 35 |
| 1973-06-11 | vs SLN | 57 | L 4-12 | 31-26 | 4 | 17,197 | Don Gullett | Bob Gibson | Bob Gibson | Don Gullett | | 246 | 219 | 27 |
| 1973-06-12 | vs SLN | 58 | L 5-11 | 31-27 | 4 | 12,396 | Ross Grimsley | Reggie Cleveland | Reggie Cleveland | Ross Grimsley | Diego Segui | 251 | 230 | 21 |
| 1973-06-13 | vs SLN | 59 | L 0-8 | 31-28 | 4 | 14,586 | Jack Billingham | Rick Wise | Rick Wise | Jack Billingham | | 251 | 238 | 13 |
| 1973-06-15 | vs PIT | 60 | W 6-0 | 32-28 | 4 | 27,029 | Fred Norman | Bob Moose | Fred Norman | Bob Moose | | 257 | 238 | 19 |
| 1973-06-16 | vs PIT | 61 | L 0-5 | 32-29 | 4 | 39,106 | Don Gullett | Nelson Briles | Nelson Briles | Don Gullett | | 257 | 243 | 14 |
| 1973-06-17 | vs PIT | 62 | W 3-1 | 34-29 | 4 | 0 | Jack Billingham | Luke Walker | Jack Billingham | Luke Walker | Tom Hall | 260 | 244 | 16 |
| 1973-06-17 | vs PIT | 63 | W 5-1 | 34-29 | 4 | 50,232 | Ross Grimsley | Tom Dettore | Ross Grimsley | Tom Dettore | | 265 | 245 | 20 |
| 1973-06-19 | @ SFN | 64 | W 4-0 | 35-29 | 4 | 13,937 | Fred Norman | Ron Bryant | Fred Norman | Ron Bryant | | 269 | 245 | 24 |
| 1973-06-20 | @ SFN | 65 | W 7-5 | 36-29 | 3 | 8,255 | Don Gullett | Elias Sosa | Don Gullett | Elias Sosa | Dave Tomlin | 276 | 250 | 26 |
| 1973-06-21 | @ SFN | 66 | L 1-7 | 36-30 | 4 | 7,904 | Jack Billingham | Tom Bradley | Tom Bradley | Jack Billingham | | 277 | 257 | 20 |
| 1973-06-22 | @ LAN | 67 | L 2-3 | 36-31 | 4 | 37,224 | Ross Grimsley | Don Sutton | Pete Richert | Clay Carroll | | 279 | 260 | 19 |
| 1973-06-23 | @ LAN | 68 | W 4-1 | 37-32 | 4 | 0 | Fred Norman | Andy Messersmith | Fred Norman | Andy Messersmith | | 283 | 261 | 22 |
| 1973-06-23 | @ LAN | 69 | L 1-5 | 37-32 | 4 | 52,831 | Tom Hall | Tommy John | Tommy John | Tom Hall | | 284 | 266 | 18 |
| 1973-06-24 | @ LAN | 70 | L 2-5 | 37-33 | 4 | 36,903 | Don Gullett | Al Downing | Al Downing | Don Gullett | | 286 | 271 | 15 |
| 1973-06-25 | @ HOU | 71 | L 2-13 | 37-34 | 4 | 25,781 | Jack Billingham | Ken Forsch | Ken Forsch | Jack Billingham | | 288 | 284 | 4 |
| 1973-06-26 | @ HOU | 72 | W 5-1 | 38-34 | 4 | 26,064 | Ross Grimsley | Don Wilson | Ross Grimsley | Don Wilson | Clay Carroll | 293 | 285 | 8 |
| 1973-06-27 | @ HOU | 73 | L 2-10 | 38-35 | 4 | 22,683 | Fred Norman | Jerry Reuss | Jerry Reuss | Fred Norman | | 295 | 295 | 0 |
| 1973-06-28 | vs SDN | 74 | L 1-6 | 38-36 | 4 | 15,756 | Don Gullett | Clay Kirby | Clay Kirby | Don Gullett | | 296 | 301 | -5 |
| 1973-06-29 | vs SDN | 75 | W 4-0 | 39-36 | 4 | 15,268 | Jack Billingham | Rich Troedson | Jack Billingham | Mike Corkins | | 300 | 301 | -1 |
| 1973-06-30 | vs LAN | 76 | L 7-8 | 39-37 | 4 | 30,580 | Tom Hall | Claude Osteen | George Culver | Ed Sprague | | 307 | 309 | -2 |
| 1973-07-01 | vs LAN | 77 | W 4-3 | 41-37 | 4 | 0 | Fred Norman | Don Sutton | Fred Norman | Don Sutton | | 311 | 312 | -1 |
| 1973-07-01 | vs LAN | 78 | W 3-2 | 41-37 | 4 | 46,047 | Ross Grimsley | Doug Rau | Pedro Borbon | Charlie Hough | | 314 | 314 | 0 |
| 1973-07-02 | vs LAN | 79 | W 4-2 | 42-37 | 4 | 16,516 | Jim McGlothlin | Andy Messersmith | Don Gullett | Jim Brewer | | 318 | 316 | 2 |
| 1973-07-03 | vs SFN | 80 | W 6-3 | 43-37 | 3 | 26,269 | Jack Billingham | Juan Marichal | Jack Billingham | Jim Willoughby | Clay Carroll | 324 | 319 | 5 |
| 1973-07-04 | vs SFN | 81 | L 2-6 | 43-38 | 4 | 21,249 | Tom Hall | Tom Bradley | Tom Bradley | Pedro Borbon | Elias Sosa | 326 | 325 | 1 |
| 1973-07-05 | vs SFN | 82 | W 4-3 | 44-38 | 4 | 23,024 | Ross Grimsley | Ron Bryant | Don Gullett | Elias Sosa | | 330 | 328 | 2 |
| 1973-07-06 | @ PHI | 83 | W 8-2 | 45-38 | 3 | 58,294 | Fred Norman | Dick Ruthven | Fred Norman | Dick Ruthven | | 338 | 330 | 8 |
| 1973-07-07 | @ PHI | 84 | W 5-4 | 46-38 | 3 | 31,250 | Jim McGlothlin | Jim Lonborg | Jim McGlothlin | Jim Lonborg | Don Gullett | 343 | 334 | 9 |
| 1973-07-08 | @ PHI | 85 | W 4-0 | 47-38 | 3 | 36,165 | Jack Billingham | Wayne Twitchell | Jack Billingham | Wayne Twitchell | | 347 | 334 | 13 |
| 1973-07-09 | @ MON | 86 | W 11-6 | 48-38 | 2 | 27,324 | Tom Hall | Bill Stoneman | Ed Sprague | Joe Gilbert | Clay Carroll | 358 | 340 | 18 |
| 1973-07-10 | @ MON | 87 | W 6-2 | 48-38 | 2 | 17,094 | Ross Grimsley | Mike Torrez | Ross Grimsley | Mike Torrez | Don Gullett | 364 | 342 | 22 |
| 1973-07-11 | @ MON | 88 | L 3-4 | 48-39 | 3 | 20,037 | Fred Norman | Steve Renko | Steve Renko | Fred Norman | Mike Marshall | 367 | 346 | 21 |
| 1973-07-13 | vs NYN | 89 | W 2-1 | 49-40 | 3 | 0 | Jack Billingham | Tom Seaver | Jack Billingham | Tom Seaver | | 369 | 347 | 22 |
| 1973-07-13 | vs NYN | 90 | L 5-7 | 49-40 | 3 | 40,283 | Jim McGlothlin | Ray Sadecki | Ray Sadecki | Jim McGlothlin | Harry Parker | 374 | 354 | 20 |
| 1973-07-14 | vs NYN | 91 | L 2-5 | 49-41 | 3 | 36,166 | Tom Hall | George Stone | George Stone | Don Gullett | Buzz Capra | 376 | 359 | 17 |
| 1973-07-15 | vs NYN | 92 | W 3-1 | 50-41 | 3 | 35,121 | Ross Grimsley | Jon Matlack | Ross Grimsley | Jon Matlack | | 379 | 360 | 19 |
| 1973-07-16 | vs PHI | 93 | W 1-0 | 51-41 | 2 | 16,457 | Fred Norman | Ken Brett | Fred Norman | Ken Brett | | 380 | 360 | 20 |
| 1973-07-17 | vs PHI | 94 | L 1-2 | 51-42 | 2 | 19,549 | Jack Billingham | Jim Lonborg | Jim Lonborg | Jack Billingham | | 381 | 362 | 19 |
| 1973-07-18 | vs PHI | 95 | W 7-3 | 52-42 | 2 | 17,429 | Tom Hall | Steve Carlton | Tom Hall | Steve Carlton | Clay Carroll | 388 | 365 | 23 |
| 1973-07-19 | vs MON | 96 | W 3-2 | 53-42 | 2 | 16,441 | Ross Grimsley | Bill Stoneman | Ross Grimsley | Bill Stoneman | Pedro Borbon | 391 | 367 | 24 |
| 1973-07-20 | vs MON | 97 | W 4-0 | 54-42 | 2 | 34,058 | Fred Norman | Mike Torrez | Fred Norman | Mike Torrez | Pedro Borbon | 395 | 367 | 28 |
| 1973-07-21 | vs MON | 98 | W 6-4 | 55-42 | 2 | 30,069 | Roger Nelson | Steve Renko | Don Gullett | Steve Renko | Clay Carroll | 401 | 371 | 30 |
| 1973-07-22 | vs MON | 99 | W 6-0 | 56-42 | 2 | 22,107 | Jack Billingham | Ernie McAnally | Jack Billingham | Ernie McAnally | | 407 | 371 | 36 |
| 1973-07-26 | vs ATL | 100 | W 5-3 | 57-43 | 3 | 0 | Fred Norman | Ron Schueler | Fred Norman | Ron Schueler | Clay Carroll | 412 | 374 | 38 |
| 1973-07-26 | vs ATL | 101 | L 4-6 | 57-43 | 3 | 47,051 | Ross Grimsley | Phil Niekro | Phil Niekro | Ross Grimsley | | 416 | 380 | 36 |
| 1973-07-27 | vs ATL | 102 | W 12-2 | 58-43 | 2 | 23,298 | Jack Billingham | Carl Morton | Jack Billingham | Carl Morton | | 428 | 382 | 46 |
| 1973-07-28 | @ SDN | 103 | W 2-1 | 59-43 | 2 | 8,860 | Tom Hall | Randy Jones | Don Gullett | Vicente Romo | | 430 | 383 | 47 |
| 1973-07-29 | @ SDN | 104 | L 1-7 | 60-44 | 2 | 0 | Gary Nolan | Rich Troedson | Rich Troedson | Gary Nolan | | 431 | 390 | 41 |
| 1973-07-29 | @ SDN | 105 | W 4-2 | 60-44 | 2 | 10,499 | Roger Nelson | Mike Caldwell | Roger Nelson | Mike Caldwell | Clay Carroll | 435 | 392 | 43 |
| 1973-07-31 | @ ATL | 106 | W 9-5 | 62-44 | 2 | 0 | Fred Norman | Carl Morton | Pedro Borbon | Carl Morton | Clay Carroll | 444 | 397 | 47 |
| 1973-07-31 | @ ATL | 107 | W 13-11 | 62-44 | 2 | 25,506 | Ross Grimsley | Jimmy Freeman | Clay Carroll | Danny Frisella | Tom Hall | 457 | 408 | 49 |
| 1973-08-01 | @ ATL | 108 | L 6-14 | 62-45 | 2 | 9,051 | Jack Billingham | Phil Niekro | Tom House | Jack Billingham | | 463 | 422 | 41 |
| 1973-08-02 | @ ATL | 109 | W 17-2 | 63-45 | 2 | 9,407 | Don Gullett | Roric Harrison | Don Gullett | Roric Harrison | | 480 | 424 | 56 |
| 1973-08-03 | vs HOU | 110 | L 0-1 | 64-46 | 2 | 0 | Gary Nolan | Don Wilson | Don Wilson | Clay Carroll | | 480 | 425 | 55 |
| 1973-08-03 | vs HOU | 111 | W 11-5 | 64-46 | 2 | 52,285 | Roger Nelson | Ken Forsch | Pedro Borbon | Tom Griffin | Clay Carroll | 491 | 430 | 61 |
| 1973-08-04 | vs HOU | 112 | W 7-6 | 65-46 | 2 | 32,215 | Fred Norman | Dave Roberts | Pedro Borbon | Cecil Upshaw | | 498 | 436 | 62 |
| 1973-08-05 | vs HOU | 113 | W 7-1 | 66-46 | 2 | 44,194 | Ross Grimsley | J.R. Richard | Ross Grimsley | J.R. Richard | | 505 | 437 | 68 |
| 1973-08-06 | vs HOU | 114 | L 4-5 | 66-47 | 2 | 29,069 | Jack Billingham | Jerry Reuss | Jerry Reuss | Jack Billingham | | 509 | 442 | 67 |
| 1973-08-07 | vs CHN | 115 | W 1-0 | 67-47 | 2 | 33,452 | Don Gullett | Rick Reuschel | Don Gullett | Rick Reuschel | | 510 | 442 | 68 |
| 1973-08-08 | vs CHN | 116 | W 4-3 | 68-47 | 2 | 33,173 | Fred Norman | Fergie Jenkins | Fred Norman | Fergie Jenkins | Tom Hall | 514 | 445 | 69 |
| 1973-08-10 | @ SLN | 117 | W 8-4 | 69-47 | 2 | 29,938 | Ross Grimsley | Rick Wise | Ross Grimsley | Rick Wise | Pedro Borbon | 522 | 449 | 73 |
| 1973-08-11 | @ SLN | 118 | W 7-5 | 70-47 | 2 | 46,473 | Jack Billingham | Reggie Cleveland | Tom Hall | Orlando Pena | | 529 | 454 | 75 |
| 1973-08-12 | @ SLN | 119 | W 7-2 | 71-47 | 2 | 34,889 | Don Gullett | Tom Murphy | Don Gullett | Tom Murphy | | 536 | 456 | 80 |
| 1973-08-13 | @ PIT | 120 | L 2-3 | 71-48 | 2 | 15,396 | Fred Norman | Nelson Briles | Nelson Briles | Fred Norman | Dave Giusti | 538 | 459 | 79 |
| 1973-08-14 | @ PIT | 121 | W 5-4 | 72-48 | 2 | 17,841 | Ross Grimsley | Jim Rooker | Clay Carroll | Ramon Hernandez | Tom Hall | 543 | 463 | 80 |
| 1973-08-15 | @ PIT | 122 | W 1-0 | 73-48 | 2 | 20,903 | Jack Billingham | Dock Ellis | Jack Billingham | Dock Ellis | | 544 | 463 | 81 |
| 1973-08-17 | @ NYN | 123 | W 2-1 | 74-48 | 2 | 36,803 | Don Gullett | George Stone | Pedro Borbon | Harry Parker | | 546 | 464 | 82 |
| 1973-08-18 | @ NYN | 124 | L 1-12 | 74-49 | 2 | 26,365 | Fred Norman | Jon Matlack | Jon Matlack | Fred Norman | | 547 | 476 | 71 |
| 1973-08-19 | @ NYN | 125 | L 1-2 | 74-50 | 2 | 33,598 | Ross Grimsley | Jerry Koosman | Jerry Koosman | Ross Grimsley | | 548 | 478 | 70 |
| 1973-08-20 | @ NYN | 126 | W 8-3 | 75-50 | 2 | 29,384 | Jack Billingham | Tom Seaver | Clay Carroll | Tug McGraw | | 556 | 481 | 75 |
| 1973-08-21 | @ CHN | 127 | L 4-6 | 75-51 | 2 | 25,454 | Don Gullett | Fergie Jenkins | Fergie Jenkins | Dave Tomlin | | 560 | 487 | 73 |
| 1973-08-22 | @ CHN | 128 | L 5-6 | 75-52 | 2 | 24,502 | Fred Norman | Milt Pappas | Milt Pappas | Fred Norman | Bob Locker | 565 | 493 | 72 |
| 1973-08-23 | @ CHN | 129 | L 3-4 | 75-53 | 2 | 17,090 | Ross Grimsley | Bill Bonham | Bob Locker | Clay Carroll | | 568 | 497 | 71 |
| 1973-08-24 | vs SLN | 130 | L 4-5 | 75-54 | 2 | 40,574 | Jack Billingham | Alan Foster | Diego Segui | Clay Carroll | | 572 | 502 | 70 |
| 1973-08-25 | vs SLN | 131 | W 6-4 | 76-54 | 2 | 50,072 | Don Gullett | Rick Wise | Don Gullett | Rick Wise | | 578 | 506 | 72 |
| 1973-08-26 | vs SLN | 132 | W 4-1 | 77-54 | 2 | 48,450 | Fred Norman | Reggie Cleveland | Fred Norman | Reggie Cleveland | Pedro Borbon | 582 | 507 | 75 |
| 1973-08-28 | vs PIT | 133 | L 3-8 | 77-55 | 2 | 31,729 | Ross Grimsley | Bob Moose | Bob Moose | Ross Grimsley | Bob Johnson | 585 | 515 | 70 |
| 1973-08-29 | vs PIT | 134 | W 5-3 | 78-55 | 2 | 30,032 | Jack Billingham | Nelson Briles | Jack Billingham | Nelson Briles | | 590 | 518 | 72 |
| 1973-08-31 | @ SDN | 135 | W 10-4 | 79-55 | 2 | 9,518 | Don Gullett | Bill Greif | Don Gullett | Bill Greif | Clay Carroll | 600 | 522 | 78 |
| 1973-09-01 | @ SDN | 136 | W 3-2 | 80-55 | 2 | 6,948 | Fred Norman | Randy Jones | Clay Carroll | Randy Jones | Tom Hall | 603 | 524 | 79 |
| 1973-09-02 | @ SDN | 137 | W 6-1 | 81-55 | 2 | 4,894 | Ross Grimsley | Steve Arlin | Ross Grimsley | Steve Arlin | | 609 | 525 | 84 |
| 1973-09-03 | @ HOU | 138 | W 4-3 | 82-55 | 1 | 10,319 | Jack Billingham | Juan Pizarro | Pedro Borbon | Juan Pizarro | | 613 | 528 | 85 |
| 1973-09-04 | @ HOU | 139 | W 12-7 | 83-55 | 1 | 3,317 | Don Gullett | Tom Griffin | Pedro Borbon | J.R. Richard | | 625 | 535 | 90 |
| 1973-09-05 | @ HOU | 140 | W 9-3 | 84-55 | 1 | 7,197 | Fred Norman | Jerry Reuss | Clay Carroll | Ken Forsch | | 634 | 538 | 96 |
| 1973-09-07 | @ ATL | 141 | L 0-5 | 84-56 | 1 | 10,884 | Ross Grimsley | Ron Schueler | Ron Schueler | Ross Grimsley | | 634 | 543 | 91 |
| 1973-09-08 | @ ATL | 142 | L 2-3 | 84-57 | 1 | 16,381 | Jack Billingham | Carl Morton | Joe Niekro | Tom Hall | | 636 | 546 | 90 |
| 1973-09-09 | @ ATL | 143 | W 14-6 | 86-57 | 1 | 0 | Fred Norman | Roric Harrison | Dick Baney | Roric Harrison | Pedro Borbon | 650 | 552 | 98 |
| 1973-09-09 | @ ATL | 144 | W 7-0 | 86-57 | 1 | 22,304 | Don Gullett | Phil Niekro | Don Gullett | Phil Niekro | | 657 | 552 | 105 |
| 1973-09-11 | vs LAN | 145 | W 6-3 | 87-57 | 1 | 46,415 | Ross Grimsley | Don Sutton | Clay Carroll | Jim Brewer | Dick Baney | 663 | 555 | 108 |
| 1973-09-12 | vs LAN | 146 | W 7-3 | 88-57 | 1 | 39,038 | Jack Billingham | Claude Osteen | Jack Billingham | Claude Osteen | | 670 | 558 | 112 |
| 1973-09-14 | vs ATL | 147 | W 7-6 | 89-57 | 1 | 33,128 | Don Gullett | Roric Harrison | Pedro Borbon | Joe Niekro | | 677 | 564 | 113 |
| 1973-09-15 | vs ATL | 148 | W 3-2 | 90-57 | 1 | 52,315 | Fred Norman | Phil Niekro | Pedro Borbon | Wenty Ford | | 680 | 566 | 114 |
| 1973-09-16 | vs ATL | 149 | W 4-3 | 91-57 | 1 | 50,381 | Ross Grimsley | Ron Schueler | Dave Tomlin | Dave Cheadle | | 684 | 569 | 115 |
| 1973-09-17 | vs HOU | 150 | L 2-5 | 91-58 | 1 | 17,585 | Jack Billingham | Dave Roberts | Dave Roberts | Jack Billingham | | 686 | 574 | 112 |
| 1973-09-18 | vs HOU | 151 | W 1-0 | 92-58 | 1 | 15,305 | Don Gullett | Jerry Reuss | Don Gullett | Jerry Reuss | | 687 | 574 | 113 |
| 1973-09-19 | @ SFN | 152 | W 5-1 | 93-58 | 1 | 6,556 | Fred Norman | Tom Bradley | Fred Norman | Tom Bradley | | 692 | 575 | 117 |
| 1973-09-20 | @ SFN | 153 | L 5-7 | 93-59 | 1 | 4,076 | Ross Grimsley | Ron Bryant | Ron Bryant | Dick Baney | Elias Sosa | 697 | 582 | 115 |
| 1973-09-21 | @ LAN | 154 | W 4-1 | 94-59 | 1 | 46,308 | Jack Billingham | Claude Osteen | Tom Hall | Claude Osteen | Pedro Borbon | 701 | 583 | 118 |
| 1973-09-22 | @ LAN | 155 | W 11-9 | 95-59 | 1 | 32,343 | Don Gullett | Don Sutton | Pedro Borbon | Don Sutton | Clay Carroll | 712 | 592 | 120 |
| 1973-09-23 | @ LAN | 156 | L 4-6 | 95-60 | 1 | 50,007 | Fred Norman | Tommy John | Tommy John | Fred Norman | Jim Brewer | 716 | 598 | 118 |
| 1973-09-24 | vs SDN | 157 | W 2-1 | 96-60 | 1 | 16,395 | Dick Baney | Rich Troedson | Dick Baney | Rich Troedson | Pedro Borbon | 718 | 599 | 119 |
| 1973-09-25 | vs SDN | 158 | W 3-2 | 97-60 | 1 | 12,724 | Jack Billingham | Bill Greif | Jack Billingham | Bill Greif | | 721 | 601 | 120 |
| 1973-09-26 | vs SDN | 159 | L 1-5 | 97-61 | 1 | 12,239 | Ross Grimsley | Randy Jones | Randy Jones | Ross Grimsley | | 722 | 606 | 116 |
| 1973-09-28 | vs SFN | 160 | L 3-5 | 97-62 | 1 | 28,112 | Don Gullett | Tom Bradley | Don McMahon | Dave Tomlin | Jim Willoughby | 725 | 611 | 114 |
| 1973-09-29 | vs SFN | 161 | W 13-6 | 98-62 | 1 | 31,107 | Fred Norman | Jim Barr | Fred Norman | Jim Barr | Dick Baney | 738 | 617 | 121 |
| 1973-09-30 | vs SFN | 162 | L 3-4 | 98-63 | 1 | 50,776 | Jack Billingham | Ron Bryant | Ron Bryant | Jack Billingham | Elias Sosa | 741 | 621 | 120 |