| 1973-04-06 | vs MON | 1 | W 3-2 | 1-0 | 1 | 40,273 | Fergie Jenkins | Mike Torrez | Bob Locker | Mike Torrez | | 3 | 2 | 1 |
| 1973-04-07 | vs MON | 2 | W 3-2 | 2-0 | 1 | 22,562 | Milt Pappas | Balor Moore | Jack Aker | Mike Marshall | | 6 | 4 | 2 |
| 1973-04-08 | vs MON | 3 | L 2-5 | 2-1 | 3 | 12,963 | Burt Hooton | Ernie McAnally | Ernie McAnally | Burt Hooton | | 8 | 9 | -1 |
| 1973-04-12 | @ PIT | 4 | L 0-6 | 2-2 | 3 | 3,764 | Fergie Jenkins | Bob Moose | Bob Moose | Fergie Jenkins | | 8 | 15 | -7 |
| 1973-04-13 | @ SLN | 5 | L 3-6 | 2-3 | 3 | 10,083 | Milt Pappas | Rick Wise | Rick Wise | Milt Pappas | Diego Segui | 11 | 21 | -10 |
| 1973-04-14 | @ SLN | 6 | W 4-1 | 3-3 | 3 | 14,305 | Rick Reuschel | Scipio Spinks | Rick Reuschel | Scipio Spinks | Jack Aker | 15 | 22 | -7 |
| 1973-04-15 | @ SLN | 7 | W 8-6 | 4-3 | 3 | 14,087 | Burt Hooton | Reggie Cleveland | Bill Bonham | John Andrews | Bob Locker | 23 | 28 | -5 |
| 1973-04-17 | @ NYN | 8 | W 1-0 | 5-3 | 2 | 14,549 | Fergie Jenkins | Tom Seaver | Fergie Jenkins | Tom Seaver | | 24 | 28 | -4 |
| 1973-04-18 | @ NYN | 9 | W 1-0 | 6-3 | 2 | 14,874 | Ray Burris | Jon Matlack | Ray Burris | Jon Matlack | Jack Aker | 25 | 28 | -3 |
| 1973-04-19 | @ NYN | 10 | L 1-3 | 7-4 | 2 | 0 | Rick Reuschel | Jerry Koosman | Jerry Koosman | Rick Reuschel | | 26 | 31 | -5 |
| 1973-04-19 | @ NYN | 11 | W 7-0 | 7-4 | 2 | 38,079 | Burt Hooton | Jim McAndrew | Burt Hooton | Jim McAndrew | | 33 | 31 | 2 |
| 1973-04-21 | vs PIT | 12 | W 10-9 | 8-4 | 2 | 16,637 | Fergie Jenkins | Nelson Briles | Bob Locker | Nelson Briles | | 43 | 40 | 3 |
| 1973-04-22 | vs PIT | 13 | L 4-10 | 9-5 | 2 | 0 | Milt Pappas | Dock Ellis | Dock Ellis | Milt Pappas | Jim Rooker | 47 | 50 | -3 |
| 1973-04-22 | vs PIT | 14 | W 11-3 | 9-5 | 2 | 28,271 | Larry Gura | Steve Blass | Larry Gura | Steve Blass | Bill Bonham | 58 | 53 | 5 |
| 1973-04-24 | vs SFN | 15 | L 2-4 | 9-6 | 2 | 14,832 | Rick Reuschel | Jim Willoughby | Randy Moffitt | Bob Locker | | 60 | 57 | 3 |
| 1973-04-25 | vs SFN | 16 | L 0-5 | 9-7 | 2 | 13,299 | Fergie Jenkins | Juan Marichal | Juan Marichal | Fergie Jenkins | | 60 | 62 | -2 |
| 1973-04-26 | vs SFN | 17 | L 3-7 | 9-8 | 3 | 7,482 | Burt Hooton | Ron Bryant | Ron Bryant | Burt Hooton | | 63 | 69 | -6 |
| 1973-04-27 | vs SDN | 18 | W 10-2 | 10-8 | 2 | 6,532 | Milt Pappas | Clay Kirby | Milt Pappas | Clay Kirby | Bob Locker | 73 | 71 | 2 |
| 1973-04-28 | vs SDN | 19 | W 2-0 | 11-8 | 2 | 12,294 | Rick Reuschel | Fred Norman | Rick Reuschel | Fred Norman | Jack Aker | 75 | 71 | 4 |
| 1973-04-29 | vs SDN | 20 | W 10-4 | 12-8 | 1 | 12,866 | Fergie Jenkins | Steve Arlin | Fergie Jenkins | Mike Caldwell | Bob Locker | 85 | 75 | 10 |
| 1973-05-01 | @ LAN | 21 | W 9-5 | 13-8 | 1 | 12,413 | Burt Hooton | Tommy John | Burt Hooton | Tommy John | Dave LaRoche | 94 | 80 | 14 |
| 1973-05-02 | @ LAN | 22 | L 1-4 | 13-9 | 1 | 13,120 | Milt Pappas | Don Sutton | Don Sutton | Milt Pappas | | 95 | 84 | 11 |
| 1973-05-03 | @ LAN | 23 | W 4-1 | 14-9 | 1 | 12,853 | Rick Reuschel | Andy Messersmith | Dave LaRoche | Andy Messersmith | Jack Aker | 99 | 85 | 14 |
| 1973-05-04 | @ SFN | 24 | L 4-5 | 14-10 | 1 | 7,181 | Fergie Jenkins | Juan Marichal | Elias Sosa | Fergie Jenkins | Randy Moffitt | 103 | 90 | 13 |
| 1973-05-05 | @ SFN | 25 | W 7-4 | 15-10 | 1 | 9,725 | Burt Hooton | Ron Bryant | Burt Hooton | Ron Bryant | Jack Aker | 110 | 94 | 16 |
| 1973-05-06 | @ SFN | 26 | L 9-11 | 15-12 | 1 | 0 | Milt Pappas | Jim Barr | Don Carrithers | Jack Aker | | 119 | 105 | 14 |
| 1973-05-06 | @ SFN | 27 | L 3-4 | 15-12 | 1 | 19,499 | Larry Gura | Jim Willoughby | Jim Willoughby | Larry Gura | Sam McDowell | 122 | 109 | 13 |
| 1973-05-07 | @ SDN | 28 | L 1-4 | 15-13 | 2 | 16,651 | Rick Reuschel | Bill Greif | Bill Greif | Rick Reuschel | | 123 | 113 | 10 |
| 1973-05-08 | @ SDN | 29 | W 3-2 | 16-13 | 1 | 4,554 | Fergie Jenkins | Fred Norman | Bob Locker | Gary Ross | Bill Bonham | 126 | 115 | 11 |
| 1973-05-09 | @ SDN | 30 | W 9-2 | 17-13 | 1 | 5,276 | Burt Hooton | Mike Corkins | Burt Hooton | Mike Corkins | | 135 | 117 | 18 |
| 1973-05-11 | vs PHI | 31 | W 4-3 | 18-13 | 1 | 5,514 | Milt Pappas | Larry Christenson | Bob Locker | Ken Brett | Jack Aker | 139 | 120 | 19 |
| 1973-05-12 | vs PHI | 32 | W 3-1 | 19-13 | 1 | 15,095 | Rick Reuschel | Wayne Twitchell | Rick Reuschel | Wayne Twitchell | | 142 | 121 | 21 |
| 1973-05-13 | vs PHI | 33 | W 4-2 | 21-13 | 1 | 0 | Fergie Jenkins | Steve Carlton | Fergie Jenkins | Steve Carlton | | 146 | 123 | 23 |
| 1973-05-13 | vs PHI | 34 | W 9-3 | 21-13 | 1 | 19,242 | Bill Bonham | Dick Ruthven | Bill Bonham | Dick Ruthven | | 155 | 126 | 29 |
| 1973-05-15 | vs NYN | 35 | W 4-3 | 22-13 | 1 | 11,517 | Burt Hooton | Jerry Koosman | Burt Hooton | Jerry Koosman | Jack Aker | 159 | 129 | 30 |
| 1973-05-16 | vs SLN | 36 | L 1-3 | 22-14 | 1 | 8,899 | Rick Reuschel | Alan Foster | Alan Foster | Rick Reuschel | Rich Folkers | 160 | 132 | 28 |
| 1973-05-17 | vs SLN | 37 | L 4-6 | 22-15 | 1 | 8,715 | Milt Pappas | Jim Bibby | Diego Segui | Jack Aker | Rich Folkers | 164 | 138 | 26 |
| 1973-05-18 | @ PHI | 38 | W 9-2 | 23-15 | 1 | 10,067 | Fergie Jenkins | Dick Ruthven | Fergie Jenkins | Dick Ruthven | | 173 | 140 | 33 |
| 1973-05-19 | @ PHI | 39 | L 0-3 | 24-16 | 1 | 0 | Burt Hooton | Ken Brett | Ken Brett | Burt Hooton | | 173 | 143 | 30 |
| 1973-05-19 | @ PHI | 40 | W 7-6 | 24-16 | 1 | 27,569 | Bill Bonham | Jim Lonborg | Bob Locker | Jim Lonborg | Jack Aker | 180 | 149 | 31 |
| 1973-05-22 | @ MON | 41 | L 3-4 | 24-17 | 1 | 10,377 | Fergie Jenkins | Steve Renko | Mike Marshall | Jack Aker | | 183 | 153 | 30 |
| 1973-05-23 | @ MON | 42 | W 4-2 | 25-17 | 1 | 11,318 | Burt Hooton | Ernie McAnally | Bill Bonham | Tom Walker | | 187 | 155 | 32 |
| 1973-05-25 | @ CIN | 43 | W 7-2 | 26-17 | 1 | 17,843 | Rick Reuschel | Don Gullett | Rick Reuschel | Don Gullett | Bob Locker | 194 | 157 | 37 |
| 1973-05-26 | @ CIN | 44 | W 2-0 | 27-17 | 1 | 24,402 | Milt Pappas | Ross Grimsley | Milt Pappas | Ross Grimsley | Jack Aker | 196 | 157 | 39 |
| 1973-05-27 | @ CIN | 45 | W 6-0 | 28-17 | 1 | 35,484 | Fergie Jenkins | Jim McGlothlin | Fergie Jenkins | Jim McGlothlin | | 202 | 157 | 45 |
| 1973-05-28 | @ CIN | 46 | L 5-6 | 28-18 | 1 | 15,453 | Burt Hooton | Jack Billingham | Tom Hall | Bob Locker | | 207 | 163 | 44 |
| 1973-05-29 | vs HOU | 47 | W 7-1 | 29-18 | 1 | 7,759 | Rick Reuschel | Jerry Reuss | Rick Reuschel | Jerry Reuss | | 214 | 164 | 50 |
| 1973-05-30 | vs HOU | 48 | L 1-4 | 29-19 | 1 | 7,807 | Milt Pappas | Ken Forsch | Ken Forsch | Milt Pappas | | 215 | 168 | 47 |
| 1973-05-31 | vs HOU | 49 | W 16-8 | 30-19 | 1 | 10,696 | Fergie Jenkins | Dave Roberts | Fergie Jenkins | Dave Roberts | Bob Locker | 231 | 176 | 55 |
| 1973-06-01 | vs ATL | 50 | L 7-8 | 30-20 | 1 | 10,626 | Burt Hooton | Roric Harrison | Pat Dobson | Jack Aker | Phil Niekro | 238 | 184 | 54 |
| 1973-06-02 | vs ATL | 51 | W 4-3 | 31-20 | 1 | 29,131 | Rick Reuschel | Carl Morton | Rick Reuschel | Ron Schueler | Dave LaRoche | 242 | 187 | 55 |
| 1973-06-03 | vs ATL | 52 | W 3-0 | 32-20 | 1 | 26,913 | Milt Pappas | Ron Reed | Milt Pappas | Ron Reed | Bob Locker | 245 | 187 | 58 |
| 1973-06-05 | vs LAN | 53 | L 1-10 | 32-21 | 1 | 12,068 | Fergie Jenkins | Claude Osteen | Claude Osteen | Fergie Jenkins | Pete Richert | 246 | 197 | 49 |
| 1973-06-06 | vs LAN | 54 | W 6-4 | 33-21 | 1 | 14,050 | Burt Hooton | Don Sutton | Burt Hooton | Don Sutton | Jack Aker | 252 | 201 | 51 |
| 1973-06-07 | vs LAN | 55 | L 0-4 | 33-22 | 1 | 12,025 | Rick Reuschel | Andy Messersmith | Andy Messersmith | Rick Reuschel | | 252 | 205 | 47 |
| 1973-06-08 | vs CIN | 56 | W 6-5 | 34-22 | 1 | 17,678 | Milt Pappas | Clay Carroll | Jack Aker | Tom Hall | | 258 | 210 | 48 |
| 1973-06-09 | vs CIN | 57 | L 4-8 | 34-23 | 1 | 32,081 | Fergie Jenkins | Jack Billingham | Pedro Borbon | Larry Gura | Ross Grimsley | 262 | 218 | 44 |
| 1973-06-10 | vs CIN | 58 | W 9-7 | 35-23 | 1 | 34,247 | Burt Hooton | Jim McGlothlin | Bill Bonham | Jim McGlothlin | Bob Locker | 271 | 225 | 46 |
| 1973-06-12 | @ HOU | 59 | W 3-0 | 36-23 | 1 | 20,132 | Rick Reuschel | Ken Forsch | Rick Reuschel | Ken Forsch | | 274 | 225 | 49 |
| 1973-06-13 | @ HOU | 60 | L 1-6 | 36-24 | 1 | 13,685 | Milt Pappas | Don Wilson | Don Wilson | Milt Pappas | Jim Ray | 275 | 231 | 44 |
| 1973-06-14 | @ HOU | 61 | W 5-4 | 37-24 | 1 | 17,359 | Fergie Jenkins | Jerry Reuss | Fergie Jenkins | Jerry Reuss | | 280 | 235 | 45 |
| 1973-06-15 | @ ATL | 62 | L 3-8 | 37-25 | 1 | 10,590 | Bill Bonham | Roric Harrison | Roric Harrison | Bill Bonham | | 283 | 243 | 40 |
| 1973-06-16 | @ ATL | 63 | W 4-3 | 38-25 | 1 | 21,613 | Rick Reuschel | Phil Niekro | Rick Reuschel | Phil Niekro | Bob Locker | 287 | 246 | 41 |
| 1973-06-17 | @ ATL | 64 | W 9-3 | 39-26 | 1 | 0 | Burt Hooton | Carl Morton | Burt Hooton | Carl Morton | | 296 | 249 | 47 |
| 1973-06-17 | @ ATL | 65 | L 5-8 | 39-26 | 1 | 23,888 | Milt Pappas | Jimmy Freeman | Ron Schueler | Juan Pizarro | Tom House | 301 | 257 | 44 |
| 1973-06-18 | @ PIT | 66 | L 1-3 | 39-27 | 1 | 11,470 | Fergie Jenkins | Dock Ellis | Dock Ellis | Fergie Jenkins | | 302 | 260 | 42 |
| 1973-06-19 | @ PIT | 67 | W 6-3 | 40-28 | 1 | 0 | Larry Gura | Bob Johnson | Larry Gura | Bob Johnson | Jack Aker | 308 | 263 | 45 |
| 1973-06-19 | @ PIT | 68 | L 3-4 | 40-28 | 1 | 28,256 | Bill Bonham | Bob Moose | Dave Giusti | Bob Locker | | 311 | 267 | 44 |
| 1973-06-20 | @ PIT | 69 | W 5-3 | 41-28 | 1 | 17,895 | Rick Reuschel | Nelson Briles | Rick Reuschel | Nelson Briles | Jack Aker | 316 | 270 | 46 |
| 1973-06-22 | @ SLN | 70 | L 0-3 | 41-29 | 1 | 34,973 | Burt Hooton | Reggie Cleveland | Reggie Cleveland | Burt Hooton | | 316 | 273 | 43 |
| 1973-06-23 | @ SLN | 71 | L 2-3 | 41-30 | 1 | 46,151 | Fergie Jenkins | Rick Wise | Diego Segui | Jack Aker | | 318 | 276 | 42 |
| 1973-06-24 | @ SLN | 72 | W 2-0 | 42-30 | 1 | 41,517 | Milt Pappas | Tom Murphy | Milt Pappas | Tom Murphy | | 320 | 276 | 44 |
| 1973-06-25 | @ NYN | 73 | W 3-2 | 43-30 | 1 | 31,984 | Rick Reuschel | Jon Matlack | Dave LaRoche | Jon Matlack | Bill Bonham | 323 | 278 | 45 |
| 1973-06-26 | @ NYN | 74 | W 5-1 | 44-30 | 1 | 18,861 | Burt Hooton | Jerry Koosman | Burt Hooton | Jerry Koosman | | 328 | 279 | 49 |
| 1973-06-27 | vs MON | 75 | W 6-1 | 45-31 | 1 | 0 | Fergie Jenkins | Balor Moore | Fergie Jenkins | Balor Moore | Bill Bonham | 334 | 280 | 54 |
| 1973-06-27 | vs MON | 76 | L 4-5 | 45-31 | 1 | 32,238 | Larry Gura | Mike Torrez | Bill Stoneman | Burt Hooton | | 338 | 285 | 53 |
| 1973-06-28 | vs MON | 77 | W 4-2 | 46-31 | 1 | 17,617 | Milt Pappas | Steve Renko | Milt Pappas | Steve Renko | Dave LaRoche | 342 | 287 | 55 |
| 1973-06-29 | vs NYN | 78 | W 4-3 | 47-31 | 1 | 22,293 | Rick Reuschel | Tom Seaver | Dave LaRoche | Buzz Capra | | 346 | 290 | 56 |
| 1973-06-30 | vs NYN | 79 | L 1-2 | 47-32 | 1 | 29,512 | Burt Hooton | Jon Matlack | Jon Matlack | Burt Hooton | | 347 | 292 | 55 |
| 1973-07-01 | vs NYN | 80 | L 5-6 | 48-33 | 1 | 0 | Fergie Jenkins | Jerry Koosman | Jerry Koosman | Fergie Jenkins | Tug McGraw | 352 | 298 | 54 |
| 1973-07-01 | vs NYN | 81 | W 6-5 | 48-33 | 1 | 42,497 | Larry Gura | Harry Parker | Jack Aker | Tug McGraw | | 358 | 303 | 55 |
| 1973-07-03 | vs PHI | 82 | L 2-8 | 48-34 | 1 | 18,849 | Milt Pappas | Jim Lonborg | Jim Lonborg | Milt Pappas | | 360 | 311 | 49 |
| 1973-07-04 | vs PHI | 83 | W 3-2 | 49-34 | 1 | 22,141 | Burt Hooton | Wayne Twitchell | Jack Aker | Bill Wilson | | 363 | 313 | 50 |
| 1973-07-05 | vs PHI | 84 | L 4-7 | 49-35 | 1 | 24,849 | Rick Reuschel | Steve Carlton | Steve Carlton | Rick Reuschel | | 367 | 320 | 47 |
| 1973-07-06 | @ SDN | 85 | W 8-5 | 50-35 | 1 | 7,768 | Fergie Jenkins | Clay Kirby | Fergie Jenkins | Clay Kirby | | 375 | 325 | 50 |
| 1973-07-07 | @ SDN | 86 | L 3-4 | 50-36 | 1 | 17,695 | Milt Pappas | Bill Greif | Bill Greif | Milt Pappas | Mike Caldwell | 378 | 329 | 49 |
| 1973-07-08 | @ SDN | 87 | L 2-4 | 50-37 | 1 | 11,786 | Burt Hooton | Randy Jones | Randy Jones | Burt Hooton | | 380 | 333 | 47 |
| 1973-07-10 | @ SFN | 88 | W 4-2 | 51-37 | 1 | 8,814 | Rick Reuschel | Ron Bryant | Rick Reuschel | Ron Bryant | | 384 | 335 | 49 |
| 1973-07-11 | @ SFN | 89 | L 3-7 | 51-38 | 1 | 7,729 | Milt Pappas | Jim Barr | Jim Barr | Dave LaRoche | Don McMahon | 387 | 342 | 45 |
| 1973-07-13 | @ LAN | 90 | L 0-5 | 51-39 | 1 | 49,058 | Fergie Jenkins | Tommy John | Tommy John | Fergie Jenkins | | 387 | 347 | 40 |
| 1973-07-14 | @ LAN | 91 | L 3-7 | 51-40 | 1 | 53,870 | Burt Hooton | Al Downing | Al Downing | Burt Hooton | Jim Brewer | 390 | 354 | 36 |
| 1973-07-15 | @ LAN | 92 | L 3-9 | 51-41 | 1 | 42,975 | Rick Reuschel | Claude Osteen | Claude Osteen | Rick Reuschel | | 393 | 363 | 30 |
| 1973-07-17 | vs SDN | 93 | L 0-1 | 51-42 | 1 | 22,194 | Milt Pappas | Steve Arlin | Steve Arlin | Milt Pappas | | 393 | 364 | 29 |
| 1973-07-18 | vs SDN | 94 | L 5-8 | 51-43 | 1 | 18,354 | Fergie Jenkins | Clay Kirby | Clay Kirby | Fergie Jenkins | Mike Caldwell | 398 | 372 | 26 |
| 1973-07-19 | vs SDN | 95 | W 12-5 | 52-43 | 1 | 15,421 | Burt Hooton | Bill Greif | Burt Hooton | Mike Corkins | Bill Bonham | 410 | 377 | 33 |
| 1973-07-20 | vs SFN | 96 | L 4-5 | 52-44 | 1 | 21,946 | Rick Reuschel | Juan Marichal | Juan Marichal | Rick Reuschel | Elias Sosa | 414 | 382 | 32 |
| 1973-07-21 | vs SFN | 97 | L 1-3 | 52-45 | 1 | 22,553 | Larry Gura | Jim Barr | Jim Barr | Larry Gura | | 415 | 385 | 30 |
| 1973-07-22 | vs SFN | 98 | L 1-4 | 52-46 | 2 | 29,278 | Fergie Jenkins | Tom Bradley | Elias Sosa | Bob Locker | Don McMahon | 416 | 389 | 27 |
| 1973-07-26 | vs PIT | 99 | L 2-3 | 52-47 | 2 | 35,770 | Rick Reuschel | Dock Ellis | Dock Ellis | Rick Reuschel | Dave Giusti | 418 | 392 | 26 |
| 1973-07-27 | vs PIT | 100 | L 6-10 | 52-48 | 2 | 22,045 | Larry Gura | Nelson Briles | Nelson Briles | Larry Gura | Dave Giusti | 424 | 402 | 22 |
| 1973-07-28 | vs SLN | 101 | L 2-7 | 52-49 | 2 | 28,031 | Fergie Jenkins | Reggie Cleveland | Reggie Cleveland | Fergie Jenkins | Al Hrabosky | 426 | 409 | 17 |
| 1973-07-29 | vs SLN | 102 | L 3-5 | 53-50 | 2 | 0 | Milt Pappas | Tom Murphy | Orlando Pena | Milt Pappas | Diego Segui | 429 | 414 | 15 |
| 1973-07-29 | vs SLN | 103 | W 5-4 | 53-50 | 2 | 38,839 | Bill Bonham | Rich Folkers | Dave LaRoche | Rich Folkers | Bob Locker | 434 | 418 | 16 |
| 1973-07-30 | vs SLN | 104 | W 3-1 | 54-50 | 2 | 29,404 | Rick Reuschel | Bob Gibson | Rick Reuschel | Bob Gibson | Dave LaRoche | 437 | 419 | 18 |
| 1973-07-31 | @ PHI | 105 | W 4-3 | 55-51 | 2 | 0 | Fergie Jenkins | Jim Lonborg | Fergie Jenkins | Jim Lonborg | Bob Locker | 441 | 422 | 19 |
| 1973-07-31 | @ PHI | 106 | L 5-6 | 55-51 | 2 | 37,003 | Milt Pappas | Ken Brett | Ken Brett | Milt Pappas | | 446 | 428 | 18 |
| 1973-08-01 | @ PHI | 107 | L 0-2 | 55-52 | 2 | 23,381 | Burt Hooton | Wayne Twitchell | Wayne Twitchell | Burt Hooton | | 446 | 430 | 16 |
| 1973-08-02 | @ PHI | 108 | L 1-4 | 55-53 | 2 | 16,855 | Bill Bonham | Dick Ruthven | Dick Ruthven | Bill Bonham | | 447 | 434 | 13 |
| 1973-08-03 | @ MON | 109 | W 3-0 | 56-53 | 2 | 18,223 | Rick Reuschel | Steve Renko | Rick Reuschel | Steve Renko | | 450 | 434 | 16 |
| 1973-08-04 | @ MON | 110 | L 1-6 | 56-54 | 2 | 25,037 | Fergie Jenkins | Steve Rogers | Steve Rogers | Fergie Jenkins | | 451 | 440 | 11 |
| 1973-08-05 | @ MON | 111 | L 2-3 | 56-55 | 3 | 31,019 | Burt Hooton | Mike Torrez | Mike Torrez | Burt Hooton | Mike Marshall | 453 | 443 | 10 |
| 1973-08-06 | @ MON | 112 | L 3-7 | 56-56 | 3 | 16,101 | Bill Bonham | Balor Moore | Balor Moore | Bill Bonham | Mike Marshall | 456 | 450 | 6 |
| 1973-08-07 | @ CIN | 113 | L 0-1 | 56-57 | 3 | 33,452 | Rick Reuschel | Don Gullett | Don Gullett | Rick Reuschel | | 456 | 451 | 5 |
| 1973-08-08 | @ CIN | 114 | L 3-4 | 56-58 | 4 | 33,173 | Fergie Jenkins | Fred Norman | Fred Norman | Fergie Jenkins | Tom Hall | 459 | 455 | 4 |
| 1973-08-10 | vs HOU | 115 | L 4-6 | 56-59 | 4 | 18,785 | Burt Hooton | J.R. Richard | J.R. Richard | Burt Hooton | Ken Forsch | 463 | 461 | 2 |
| 1973-08-11 | vs HOU | 116 | L 4-6 | 56-60 | 4 | 21,818 | Rick Reuschel | Jerry Reuss | Larry Dierker | Rick Reuschel | Ken Forsch | 467 | 467 | 0 |
| 1973-08-12 | vs HOU | 117 | L 2-3 | 56-61 | 4 | 22,010 | Bill Bonham | Don Wilson | Don Wilson | Bill Bonham | Jim Ray | 469 | 470 | -1 |
| 1973-08-14 | vs ATL | 118 | L 2-6 | 56-62 | 4 | 24,553 | Fergie Jenkins | Carl Morton | Carl Morton | Fergie Jenkins | | 471 | 476 | -5 |
| 1973-08-15 | vs ATL | 119 | L 1-15 | 56-63 | 4 | 21,652 | Rick Reuschel | Phil Niekro | Phil Niekro | Rick Reuschel | | 472 | 491 | -19 |
| 1973-08-16 | vs ATL | 120 | L 2-10 | 56-64 | 4 | 17,682 | Milt Pappas | Roric Harrison | Joe Niekro | Bob Locker | Danny Frisella | 474 | 501 | -27 |
| 1973-08-17 | vs LAN | 121 | W 5-1 | 57-64 | 4 | 13,987 | Bill Bonham | Andy Messersmith | Bill Bonham | Andy Messersmith | Bob Locker | 479 | 502 | -23 |
| 1973-08-18 | vs LAN | 122 | W 2-1 | 58-64 | 4 | 24,893 | Burt Hooton | Claude Osteen | Burt Hooton | Claude Osteen | | 481 | 503 | -22 |
| 1973-08-19 | vs LAN | 123 | L 1-2 | 58-65 | 4 | 25,266 | Rick Reuschel | Tommy John | Jim Brewer | Rick Reuschel | | 482 | 505 | -23 |
| 1973-08-21 | vs CIN | 124 | W 6-4 | 59-65 | 4 | 25,454 | Fergie Jenkins | Don Gullett | Fergie Jenkins | Dave Tomlin | | 488 | 509 | -21 |
| 1973-08-22 | vs CIN | 125 | W 6-5 | 60-65 | 4 | 24,502 | Milt Pappas | Fred Norman | Milt Pappas | Fred Norman | Bob Locker | 494 | 514 | -20 |
| 1973-08-23 | vs CIN | 126 | W 4-3 | 61-65 | 4 | 17,090 | Bill Bonham | Ross Grimsley | Bob Locker | Clay Carroll | | 498 | 517 | -19 |
| 1973-08-24 | @ HOU | 127 | L 2-4 | 61-66 | 4 | 13,768 | Burt Hooton | Jerry Reuss | Jerry Reuss | Burt Hooton | | 500 | 521 | -21 |
| 1973-08-25 | @ HOU | 128 | W 4-3 | 62-66 | 4 | 17,103 | Rick Reuschel | Dave Roberts | Bob Locker | Jim Ray | | 504 | 524 | -20 |
| 1973-08-26 | @ HOU | 129 | W 4-2 | 63-66 | 3 | 15,238 | Fergie Jenkins | Don Wilson | Fergie Jenkins | Don Wilson | Bill Bonham | 508 | 526 | -18 |
| 1973-08-28 | @ ATL | 130 | W 9-6 | 64-66 | 3 | 7,566 | Milt Pappas | Ron Schueler | Burt Hooton | Joe Niekro | Bob Locker | 517 | 532 | -15 |
| 1973-08-29 | @ ATL | 131 | L 4-7 | 64-67 | 3 | 6,238 | Bill Bonham | Carl Morton | Tom House | Ray Burris | Roric Harrison | 521 | 539 | -18 |
| 1973-08-31 | @ PIT | 132 | L 0-7 | 64-69 | 4 | 0 | Rick Reuschel | Jim Rooker | Jim Rooker | Rick Reuschel | | 521 | 546 | -25 |
| 1973-08-31 | @ PIT | 133 | L 2-5 | 64-69 | 4 | 35,884 | Fergie Jenkins | John Morlan | Bob Johnson | Fergie Jenkins | Ramon Hernandez | 523 | 551 | -28 |
| 1973-09-01 | @ PIT | 134 | L 0-1 | 64-70 | 4 | 13,484 | Burt Hooton | Bruce Kison | Dave Giusti | Burt Hooton | | 523 | 552 | -29 |
| 1973-09-02 | @ PIT | 135 | W 5-3 | 65-70 | 4 | 19,130 | Bill Bonham | Bob Moose | Bob Locker | Ramon Hernandez | | 528 | 555 | -27 |
| 1973-09-03 | @ MON | 136 | L 2-5 | 65-71 | 4 | 20,165 | Milt Pappas | Steve Renko | Steve Renko | Milt Pappas | Mike Marshall | 530 | 560 | -30 |
| 1973-09-04 | @ MON | 137 | L 2-3 | 65-72 | 4 | 18,667 | Fergie Jenkins | Steve Rogers | Steve Rogers | Fergie Jenkins | Mike Marshall | 532 | 563 | -31 |
| 1973-09-06 | @ MON | 138 | L 3-5 | 65-73 | 5 | 9,306 | Rick Reuschel | Balor Moore | Chuck Taylor | Rick Reuschel | | 535 | 568 | -33 |
| 1973-09-07 | vs SLN | 139 | W 8-2 | 66-73 | 5 | 7,704 | Burt Hooton | Rick Wise | Burt Hooton | Rick Wise | | 543 | 570 | -27 |
| 1973-09-08 | vs SLN | 140 | W 3-1 | 67-73 | 5 | 28,471 | Milt Pappas | Reggie Cleveland | Milt Pappas | Reggie Cleveland | Bob Locker | 546 | 571 | -25 |
| 1973-09-09 | vs SLN | 141 | W 5-4 | 68-73 | 5 | 26,029 | Fergie Jenkins | Mike Nagy | Bob Locker | Al Hrabosky | | 551 | 575 | -24 |
| 1973-09-10 | vs PIT | 142 | L 3-11 | 68-74 | 5 | 7,255 | Rick Reuschel | Jim Rooker | Jim Rooker | Rick Reuschel | | 554 | 586 | -32 |
| 1973-09-11 | vs PIT | 143 | W 2-0 | 69-74 | 4 | 8,516 | Burt Hooton | Steve Blass | Burt Hooton | Steve Blass | | 556 | 586 | -30 |
| 1973-09-12 | vs PIT | 144 | L 2-4 | 69-75 | 5 | 9,857 | Mike Paul | Bruce Kison | Bruce Kison | Mike Paul | Dave Giusti | 558 | 590 | -32 |
| 1973-09-13 | vs PIT | 145 | L 1-6 | 69-76 | 5 | 7,375 | Milt Pappas | Bob Moose | Bob Moose | Milt Pappas | Ramon Hernandez | 559 | 596 | -37 |
| 1973-09-15 | @ NYN | 146 | L 1-5 | 70-77 | 5 | 0 | Fergie Jenkins | George Stone | George Stone | Fergie Jenkins | Tug McGraw | 560 | 601 | -41 |
| 1973-09-15 | @ NYN | 147 | W 7-0 | 70-77 | 5 | 25,553 | Rick Reuschel | Ray Sadecki | Rick Reuschel | Ray Sadecki | | 567 | 601 | -34 |
| 1973-09-16 | @ NYN | 148 | L 3-4 | 70-78 | 5 | 25,681 | Burt Hooton | Jerry Koosman | Tug McGraw | Burt Hooton | | 570 | 605 | -35 |
| 1973-09-18 | vs PHI | 149 | L 2-5 | 71-79 | 5 | 0 | Milt Pappas | Wayne Twitchell | Barry Lersch | Bob Locker | Mac Scarce | 572 | 610 | -38 |
| 1973-09-18 | vs PHI | 150 | W 3-2 | 71-79 | 5 | 2,757 | Bill Bonham | Ken Brett | Bill Bonham | Ken Brett | | 575 | 612 | -37 |
| 1973-09-19 | vs MON | 151 | W 8-6 | 72-79 | 5 | 2,568 | Rick Reuschel | Mike Torrez | Rick Reuschel | Mike Marshall | Bob Locker | 583 | 618 | -35 |
| 1973-09-20 | vs MON | 152 | W 5-4 | 73-79 | 5 | 1,957 | Fergie Jenkins | Steve Renko | Fergie Jenkins | Steve Renko | Bob Locker | 588 | 622 | -34 |
| 1973-09-21 | vs MON | 153 | W 3-1 | 74-79 | 5 | 2,540 | Burt Hooton | Steve Rogers | Burt Hooton | Steve Rogers | Bob Locker | 591 | 623 | -32 |
| 1973-09-22 | @ PHI | 154 | W 5-2 | 75-79 | 5 | 22,273 | Bill Bonham | Barry Lersch | Bill Bonham | Mac Scarce | | 596 | 625 | -29 |
| 1973-09-23 | @ PHI | 155 | L 7-9 | 75-80 | 5 | 9,991 | Rick Reuschel | Ken Brett | Ken Brett | Burt Hooton | Ron Diorio | 603 | 634 | -31 |
| 1973-09-25 | @ SLN | 156 | W 4-3 | 76-80 | 4 | 14,854 | Fergie Jenkins | Alan Foster | Fergie Jenkins | Al Hrabosky | Bob Locker | 607 | 637 | -30 |
| 1973-09-26 | @ SLN | 157 | L 0-1 | 76-81 | 5 | 14,379 | Bill Bonham | Rick Wise | Rick Wise | Bill Bonham | | 607 | 638 | -31 |
| 1973-09-27 | @ SLN | 158 | L 0-2 | 76-82 | 5 | 13,014 | Burt Hooton | Reggie Cleveland | Reggie Cleveland | Burt Hooton | | 607 | 640 | -33 |
| 1973-09-30 | vs NYN | 159 | W 1-0 | 77-83 | 5 | 0 | Rick Reuschel | Jon Matlack | Bob Locker | Jon Matlack | | 608 | 640 | -32 |
| 1973-09-30 | vs NYN | 160 | L 2-9 | 77-83 | 5 | 21,432 | Fergie Jenkins | Jerry Koosman | Jerry Koosman | Fergie Jenkins | | 610 | 649 | -39 |
| 1973-10-01 | vs NYN | 161 | L 4-6 | 77-84 | 5 | 1,913 | Burt Hooton | Tom Seaver | Tom Seaver | Burt Hooton | Tug McGraw | 614 | 655 | -41 |