| 1973-04-06 | vs MIL | 1 | W 10-0 | 1-0 | 1 | 26,543 | Dave McNally | Jim Colborn | Dave McNally | Jim Colborn | | 10 | 0 | 10 |
| 1973-04-07 | vs MIL | 2 | W 8-7 | 2-0 | 1 | 6,740 | Mike Cuellar | Skip Lockwood | Doyle Alexander | Jerry Bell | | 18 | 7 | 11 |
| 1973-04-11 | @ DET | 3 | W 3-1 | 3-0 | 1 | 46,389 | Jim Palmer | Woodie Fryman | Eddie Watt | Lerrin LaGrow | | 21 | 8 | 13 |
| 1973-04-12 | @ DET | 4 | W 1-0 | 4-0 | 1 | 6,303 | Dave McNally | Mickey Lolich | Dave McNally | Mickey Lolich | Orlando Pena | 22 | 8 | 14 |
| 1973-04-13 | @ MIL | 5 | L 0-2 | 4-1 | 2 | 13,883 | Mike Cuellar | Bill Parsons | Bill Parsons | Mike Cuellar | Jerry Bell | 22 | 10 | 12 |
| 1973-04-14 | @ MIL | 6 | W 5-1 | 5-1 | 2 | 6,516 | Doyle Alexander | Skip Lockwood | Doyle Alexander | Skip Lockwood | | 27 | 11 | 16 |
| 1973-04-15 | @ MIL | 7 | L 2-3 | 6-2 | 2 | 0 | Jim Palmer | Jim Slaton | Jerry Bell | Bob Reynolds | | 29 | 14 | 15 |
| 1973-04-15 | @ MIL | 8 | W 5-4 | 6-2 | 2 | 14,694 | Orlando Pena | Gary Ryerson | Eddie Watt | Jerry Bell | | 34 | 18 | 16 |
| 1973-04-17 | vs NYA | 9 | W 4-2 | 7-2 | 1 | 10,068 | Dave McNally | Steve Kline | Dave McNally | Steve Kline | | 38 | 20 | 18 |
| 1973-04-18 | vs NYA | 10 | L 4-7 | 7-3 | 1 | 10,138 | Mike Cuellar | Doc Medich | Lindy McDaniel | Mike Cuellar | | 42 | 27 | 15 |
| 1973-04-19 | vs NYA | 11 | L 1-6 | 7-4 | 1 | 8,270 | Jim Palmer | Fritz Peterson | Fritz Peterson | Jim Palmer | Lindy McDaniel | 43 | 33 | 10 |
| 1973-04-20 | vs DET | 12 | W 6-5 | 8-4 | 1 | 14,626 | Doyle Alexander | Mickey Lolich | Bob Reynolds | Lerrin LaGrow | | 49 | 38 | 11 |
| 1973-04-21 | vs DET | 13 | L 1-3 | 8-5 | 1 | 15,448 | Dave McNally | Joe Coleman | Joe Coleman | Dave McNally | | 50 | 41 | 9 |
| 1973-04-22 | vs DET | 14 | W 5-3 | 9-5 | 1 | 12,883 | Mike Cuellar | Jim Perry | Mike Cuellar | Jim Perry | | 55 | 44 | 11 |
| 1973-04-24 | @ CAL | 15 | L 5-6 | 9-6 | 1 | 7,488 | Doyle Alexander | Clyde Wright | Dave Sells | Eddie Watt | | 60 | 50 | 10 |
| 1973-04-25 | @ CAL | 16 | L 0-1 | 9-7 | 1 | 7,061 | Dave McNally | Bill Singer | Bill Singer | Dave McNally | | 60 | 51 | 9 |
| 1973-04-27 | @ OAK | 17 | L 3-4 | 9-8 | 1 | 5,971 | Mike Cuellar | Blue Moon Odom | Horacio Pina | Eddie Watt | | 63 | 55 | 8 |
| 1973-04-28 | @ OAK | 18 | W 2-1 | 10-8 | 1 | 6,380 | Jim Palmer | Ken Holtzman | Jim Palmer | Ken Holtzman | | 65 | 56 | 9 |
| 1973-04-29 | @ OAK | 19 | L 3-4 | 10-9 | 1 | 18,306 | Dave McNally | Catfish Hunter | Catfish Hunter | Dave McNally | Rollie Fingers | 68 | 60 | 8 |
| 1973-05-01 | @ CHA | 20 | L 5-6 | 10-10 | 2 | 8,982 | Mike Cuellar | Eddie Fisher | Eddie Fisher | Mike Cuellar | Cy Acosta | 73 | 66 | 7 |
| 1973-05-02 | @ CHA | 21 | L 0-4 | 10-11 | 2 | 7,313 | Jim Palmer | Wilbur Wood | Wilbur Wood | Jim Palmer | | 73 | 70 | 3 |
| 1973-05-04 | vs CAL | 22 | L 0-1 | 10-12 | 3 | 14,392 | Dave McNally | Rudy May | Rudy May | Dave McNally | | 73 | 71 | 2 |
| 1973-05-05 | vs CAL | 23 | L 1-3 | 10-13 | 4 | 7,177 | Mike Cuellar | Bill Singer | Bill Singer | Mike Cuellar | | 74 | 74 | 0 |
| 1973-05-06 | vs CAL | 24 | W 5-0 | 11-13 | 3 | 11,282 | Jim Palmer | Nolan Ryan | Jim Palmer | Nolan Ryan | | 79 | 74 | 5 |
| 1973-05-07 | vs OAK | 25 | W 8-2 | 12-13 | 1 | 6,076 | Doyle Alexander | Rollie Fingers | Doyle Alexander | Rollie Fingers | | 87 | 76 | 11 |
| 1973-05-09 | vs OAK | 26 | L 3-4 | 12-14 | 4 | 7,618 | Dave McNally | Catfish Hunter | Catfish Hunter | Dave McNally | Darold Knowles | 90 | 80 | 10 |
| 1973-05-11 | @ NYA | 27 | W 3-0 | 13-14 | 2 | 11,936 | Jim Palmer | Steve Kline | Jim Palmer | Steve Kline | | 93 | 80 | 13 |
| 1973-05-12 | @ NYA | 28 | L 0-8 | 13-15 | 3 | 10,341 | Mike Cuellar | Doc Medich | Doc Medich | Mike Cuellar | | 93 | 88 | 5 |
| 1973-05-13 | @ NYA | 29 | L 0-4 | 14-16 | 2 | 0 | Orlando Pena | Mel Stottlemyre | Mel Stottlemyre | Orlando Pena | Sparky Lyle | 93 | 92 | 1 |
| 1973-05-13 | @ NYA | 30 | W 9-6 | 14-16 | 2 | 23,183 | Dave McNally | Mike Kekich | Eddie Watt | Lindy McDaniel | Grant Jackson | 102 | 98 | 4 |
| 1973-05-14 | @ BOS | 31 | L 0-1 | 14-17 | 5 | 13,020 | Doyle Alexander | Bill Lee | Bobby Bolin | Bob Reynolds | | 102 | 99 | 3 |
| 1973-05-17 | @ CLE | 32 | W 4-1 | 15-17 | 3 | 3,196 | Jim Palmer | Gaylord Perry | Jim Palmer | Gaylord Perry | | 106 | 100 | 6 |
| 1973-05-18 | @ CLE | 33 | W 6-2 | 16-17 | 2 | 6,064 | Mike Cuellar | Dick Tidrow | Orlando Pena | Dick Tidrow | | 112 | 102 | 10 |
| 1973-05-19 | vs BOS | 34 | W 3-1 | 17-17 | 2 | 12,801 | Doyle Alexander | Bill Lee | Doyle Alexander | Bill Lee | | 115 | 103 | 12 |
| 1973-05-21 | vs BOS | 35 | L 1-4 | 17-18 | 2 | 7,105 | Jim Palmer | Luis Tiant | Luis Tiant | Jim Palmer | | 116 | 107 | 9 |
| 1973-05-22 | vs CLE | 36 | L 3-5 | 17-19 | 4 | 5,404 | Dave McNally | Dick Tidrow | Tom Hilgendorf | Dave McNally | Jerry Johnson | 119 | 112 | 7 |
| 1973-05-26 | @ MIN | 37 | W 7-2 | 18-19 | 3 | 7,754 | Mike Cuellar | Dick Woodson | Mike Cuellar | Dick Woodson | | 126 | 114 | 12 |
| 1973-05-28 | @ MIN | 38 | L 3-10 | 18-20 | 3 | 13,522 | Doyle Alexander | Jim Kaat | Jim Kaat | Doyle Alexander | | 129 | 124 | 5 |
| 1973-05-29 | @ KCA | 39 | W 3-2 | 19-20 | 3 | 10,417 | Jim Palmer | Paul Splittorff | Jim Palmer | Paul Splittorff | | 132 | 126 | 6 |
| 1973-05-30 | @ KCA | 40 | W 5-4 | 20-20 | 3 | 11,378 | Dave McNally | Wayne Simpson | Dave McNally | Wayne Simpson | Bob Reynolds | 137 | 130 | 7 |
| 1973-05-31 | @ KCA | 41 | L 1-4 | 20-21 | 3 | 11,975 | Mike Cuellar | Gene Garber | Gene Garber | Mike Cuellar | | 138 | 134 | 4 |
| 1973-06-01 | @ TEX | 42 | L 3-4 | 20-22 | 4 | 6,300 | Doyle Alexander | Jim Merritt | Mike Paul | Bob Reynolds | | 141 | 138 | 3 |
| 1973-06-02 | @ TEX | 43 | W 8-3 | 21-22 | 3 | 13,693 | Jim Palmer | Lloyd Allen | Jim Palmer | Lloyd Allen | | 149 | 141 | 8 |
| 1973-06-03 | @ TEX | 44 | W 7-1 | 22-22 | 3 | 6,905 | Dave McNally | Pete Broberg | Dave McNally | Pete Broberg | | 156 | 142 | 14 |
| 1973-06-05 | vs CHA | 45 | W 7-4 | 23-22 | 3 | 17,601 | Mike Cuellar | Wilbur Wood | Grant Jackson | Wilbur Wood | | 163 | 146 | 17 |
| 1973-06-06 | vs CHA | 46 | W 14-4 | 24-22 | 3 | 8,611 | Doyle Alexander | Eddie Fisher | Doyle Alexander | Eddie Fisher | Grant Jackson | 177 | 150 | 27 |
| 1973-06-07 | vs CHA | 47 | L 2-3 | 24-23 | 3 | 8,647 | Jim Palmer | Steve Stone | Steve Stone | Jim Palmer | Terry Forster | 179 | 153 | 26 |
| 1973-06-08 | vs MIN | 48 | L 0-2 | 24-24 | 3 | 21,208 | Dave McNally | Bert Blyleven | Bert Blyleven | Dave McNally | | 179 | 155 | 24 |
| 1973-06-09 | vs MIN | 49 | W 7-4 | 25-24 | 3 | 19,603 | Mike Cuellar | Bill Hands | Bob Reynolds | Bill Hands | Grant Jackson | 186 | 159 | 27 |
| 1973-06-10 | vs MIN | 50 | L 4-11 | 25-25 | 3 | 18,210 | Doyle Alexander | Dick Woodson | Dick Woodson | Doyle Alexander | Ray Corbin | 190 | 170 | 20 |
| 1973-06-12 | vs KCA | 51 | W 6-4 | 26-25 | 4 | 6,406 | Jim Palmer | Steve Busby | Grant Jackson | Doug Bird | | 196 | 174 | 22 |
| 1973-06-13 | vs KCA | 52 | L 0-2 | 26-26 | 4 | 8,059 | Dave McNally | Dick Drago | Dick Drago | Dave McNally | | 196 | 176 | 20 |
| 1973-06-14 | vs KCA | 53 | W 8-3 | 27-26 | 4 | 6,067 | Doyle Alexander | Mark Littell | Grant Jackson | Gene Garber | | 204 | 179 | 25 |
| 1973-06-15 | vs TEX | 54 | W 1-0 | 28-26 | 3 | 7,792 | Mike Cuellar | Sonny Siebert | Mike Cuellar | Sonny Siebert | | 205 | 179 | 26 |
| 1973-06-16 | vs TEX | 55 | W 9-1 | 29-26 | 2 | 8,587 | Jim Palmer | Steve Dunning | Jim Palmer | Steve Dunning | | 214 | 180 | 34 |
| 1973-06-17 | vs TEX | 56 | W 5-4 | 30-26 | 2 | 14,497 | Dave McNally | Jim Merritt | Bob Reynolds | Don Stanhouse | | 219 | 184 | 35 |
| 1973-06-19 | @ NYA | 57 | L 4-5 | 30-27 | 3 | 13,368 | Doyle Alexander | Doc Medich | Fred Beene | Doyle Alexander | Sparky Lyle | 223 | 189 | 34 |
| 1973-06-20 | @ NYA | 58 | L 1-2 | 30-28 | 3 | 16,371 | Mike Cuellar | Mel Stottlemyre | Mel Stottlemyre | Mike Cuellar | Sparky Lyle | 224 | 191 | 33 |
| 1973-06-21 | @ BOS | 59 | W 6-3 | 31-28 | 2 | 21,876 | Jim Palmer | Luis Tiant | Bob Reynolds | Luis Tiant | Grant Jackson | 230 | 194 | 36 |
| 1973-06-23 | @ BOS | 60 | L 1-5 | 32-29 | 3 | 0 | Dave McNally | Ray Culp | Ray Culp | Dave McNally | Bobby Bolin | 231 | 199 | 32 |
| 1973-06-23 | @ BOS | 61 | W 2-1 | 32-29 | 3 | 30,676 | Jesse Jefferson | Marty Pattin | Jesse Jefferson | Marty Pattin | | 233 | 200 | 33 |
| 1973-06-24 | @ BOS | 62 | L 0-1 | 32-30 | 3 | 26,244 | Doyle Alexander | John Curtis | John Curtis | Doyle Alexander | | 233 | 201 | 32 |
| 1973-06-25 | @ MIL | 63 | W 4-3 | 33-30 | 3 | 12,140 | Mike Cuellar | Jerry Bell | Mike Cuellar | Frank Linzy | | 237 | 204 | 33 |
| 1973-06-26 | @ MIL | 64 | W 6-0 | 34-30 | 2 | 22,004 | Jim Palmer | Jim Colborn | Jim Palmer | Jim Colborn | | 243 | 204 | 39 |
| 1973-06-27 | vs NYA | 65 | W 4-0 | 35-30 | 2 | 21,822 | Dave McNally | Fritz Peterson | Dave McNally | Fritz Peterson | | 247 | 204 | 43 |
| 1973-06-28 | vs NYA | 66 | W 6-3 | 36-30 | 2 | 26,012 | Jesse Jefferson | Sam McDowell | Grant Jackson | Sam McDowell | | 253 | 207 | 46 |
| 1973-06-29 | @ DET | 67 | W 9-2 | 37-30 | 2 | 35,247 | Doyle Alexander | Jim Perry | Doyle Alexander | Jim Perry | | 262 | 209 | 53 |
| 1973-06-30 | @ DET | 68 | L 1-4 | 37-31 | 2 | 27,085 | Mike Cuellar | Mike Strahler | Mike Strahler | Mike Cuellar | John Hiller | 263 | 213 | 50 |
| 1973-07-01 | @ DET | 69 | L 3-5 | 37-33 | 2 | 0 | Jim Palmer | Joe Coleman | Joe Coleman | Jim Palmer | John Hiller | 266 | 218 | 48 |
| 1973-07-01 | @ DET | 70 | L 0-1 | 37-33 | 2 | 48,273 | Dave McNally | Mickey Lolich | Mickey Lolich | Dave McNally | | 266 | 219 | 47 |
| 1973-07-02 | vs MIL | 71 | L 3-5 | 37-34 | 2 | 6,855 | Jesse Jefferson | Jerry Bell | Bill Champion | Jesse Jefferson | Frank Linzy | 269 | 224 | 45 |
| 1973-07-03 | vs MIL | 72 | W 9-7 | 39-34 | 2 | 0 | Doyle Alexander | Chris Short | Grant Jackson | Frank Linzy | Jim Palmer | 278 | 231 | 47 |
| 1973-07-03 | vs MIL | 73 | W 6-4 | 39-34 | 2 | 10,326 | Bob Reynolds | Eduardo Rodriguez | Jesse Jefferson | Bill Champion | | 284 | 235 | 49 |
| 1973-07-04 | vs MIL | 74 | W 10-7 | 40-34 | 2 | 9,843 | Mike Cuellar | Jim Slaton | Bob Reynolds | Bill Champion | | 294 | 242 | 52 |
| 1973-07-06 | vs OAK | 75 | L 5-7 | 41-35 | 2 | 0 | Jim Palmer | Catfish Hunter | Catfish Hunter | Jim Palmer | Rollie Fingers | 299 | 249 | 50 |
| 1973-07-06 | vs OAK | 76 | W 5-3 | 41-35 | 2 | 23,320 | Dave McNally | Vida Blue | Dave McNally | Vida Blue | Eddie Watt | 304 | 252 | 52 |
| 1973-07-07 | vs OAK | 77 | L 4-5 | 41-36 | 2 | 42,180 | Mike Cuellar | Ken Holtzman | Ken Holtzman | Mike Cuellar | Darold Knowles | 308 | 257 | 51 |
| 1973-07-08 | vs OAK | 78 | L 5-6 | 41-37 | 3 | 18,267 | Jesse Jefferson | Dave Hamilton | Rollie Fingers | Bob Reynolds | | 313 | 263 | 50 |
| 1973-07-09 | vs CAL | 79 | W 5-3 | 42-37 | 3 | 8,677 | Dave McNally | Clyde Wright | Dave McNally | Clyde Wright | Bob Reynolds | 318 | 266 | 52 |
| 1973-07-10 | vs CAL | 80 | L 8-10 | 42-38 | 3 | 9,649 | Jim Palmer | Rudy May | Dick Lange | Eddie Watt | | 326 | 276 | 50 |
| 1973-07-11 | vs CAL | 81 | W 7-1 | 43-38 | 3 | 9,389 | Mike Cuellar | Nolan Ryan | Mike Cuellar | Nolan Ryan | | 333 | 277 | 56 |
| 1973-07-12 | @ CHA | 82 | W 4-3 | 44-38 | 3 | 16,772 | Jesse Jefferson | Bart Johnson | Jesse Jefferson | Terry Forster | Grant Jackson | 337 | 280 | 57 |
| 1973-07-13 | @ CHA | 83 | L 2-3 | 44-39 | 3 | 25,569 | Dave McNally | Wilbur Wood | Wilbur Wood | Bob Reynolds | | 339 | 283 | 56 |
| 1973-07-14 | @ CHA | 84 | W 5-4 | 45-39 | 3 | 28,103 | Jim Palmer | Stan Bahnsen | Jim Palmer | Stan Bahnsen | Bob Reynolds | 344 | 287 | 57 |
| 1973-07-15 | @ CHA | 85 | W 3-2 | 46-39 | 3 | 22,824 | Mike Cuellar | Steve Stone | Mike Cuellar | Steve Stone | | 347 | 289 | 58 |
| 1973-07-16 | @ OAK | 86 | W 7-5 | 47-39 | 3 | 43,571 | Jesse Jefferson | Catfish Hunter | Don Hood | Horacio Pina | | 354 | 294 | 60 |
| 1973-07-17 | @ OAK | 87 | L 1-3 | 47-40 | 2 | 7,276 | Dave McNally | Vida Blue | Vida Blue | Dave McNally | | 355 | 297 | 58 |
| 1973-07-18 | @ OAK | 88 | W 5-2 | 48-40 | 2 | 6,594 | Jim Palmer | Ken Holtzman | Jim Palmer | Ken Holtzman | | 360 | 299 | 61 |
| 1973-07-19 | @ CAL | 89 | W 3-1 | 49-40 | 2 | 20,823 | Mike Cuellar | Nolan Ryan | Mike Cuellar | Nolan Ryan | | 363 | 300 | 63 |
| 1973-07-20 | @ CAL | 90 | L 3-8 | 49-41 | 2 | 40,257 | Jesse Jefferson | Bill Singer | Bill Singer | Jesse Jefferson | | 366 | 308 | 58 |
| 1973-07-21 | @ CAL | 91 | W 5-3 | 50-41 | 2 | 14,931 | Dave McNally | Clyde Wright | Dave McNally | Clyde Wright | Grant Jackson | 371 | 311 | 60 |
| 1973-07-22 | @ CAL | 92 | W 8-2 | 51-41 | 2 | 11,743 | Jim Palmer | Rudy May | Jim Palmer | Rudy May | | 379 | 313 | 66 |
| 1973-07-26 | vs CLE | 93 | W 8-4 | 52-42 | 2 | 0 | Dave McNally | Gaylord Perry | Don Hood | Gaylord Perry | | 387 | 317 | 70 |
| 1973-07-26 | vs CLE | 94 | L 4-6 | 52-42 | 2 | 11,063 | Mike Cuellar | Dick Tidrow | Dick Tidrow | Mike Cuellar | Tom Hilgendorf | 391 | 323 | 68 |
| 1973-07-27 | vs CLE | 95 | W 9-0 | 54-42 | 2 | 0 | Jim Palmer | Dick Bosman | Jim Palmer | Dick Bosman | | 400 | 323 | 77 |
| 1973-07-27 | vs CLE | 96 | W 5-2 | 54-42 | 2 | 10,857 | Jesse Jefferson | Brent Strom | Bob Reynolds | Brent Strom | | 405 | 325 | 80 |
| 1973-07-28 | vs DET | 97 | L 2-3 | 54-43 | 2 | 29,509 | Mike Cuellar | Joe Coleman | Joe Coleman | Mike Cuellar | Bob Miller | 407 | 328 | 79 |
| 1973-07-29 | vs DET | 98 | L 3-8 | 54-44 | 2 | 16,504 | Don Hood | Mike Strahler | Mike Strahler | Don Hood | | 410 | 336 | 74 |
| 1973-07-30 | vs DET | 99 | L 3-4 | 54-45 | 2 | 15,584 | Jesse Jefferson | Mickey Lolich | Mickey Lolich | Jesse Jefferson | John Hiller | 413 | 340 | 73 |
| 1973-07-31 | @ CLE | 100 | W 5-1 | 55-45 | 2 | 17,912 | Jim Palmer | Dick Tidrow | Jim Palmer | Dick Tidrow | | 418 | 341 | 77 |
| 1973-08-01 | @ CLE | 101 | W 4-2 | 56-45 | 1 | 3,564 | Mike Cuellar | Dick Bosman | Mike Cuellar | Dick Bosman | Bob Reynolds | 422 | 343 | 79 |
| 1973-08-02 | @ CLE | 102 | L 0-6 | 56-46 | 1 | 3,980 | Don Hood | Gaylord Perry | Gaylord Perry | Don Hood | | 422 | 349 | 73 |
| 1973-08-03 | vs BOS | 103 | L 5-8 | 57-47 | 1 | 0 | Dave McNally | Luis Tiant | Luis Tiant | Dave McNally | | 427 | 357 | 70 |
| 1973-08-03 | vs BOS | 104 | W 8-2 | 57-47 | 1 | 16,712 | Jesse Jefferson | Dick Pole | Jesse Jefferson | Dick Pole | | 435 | 359 | 76 |
| 1973-08-04 | vs BOS | 105 | W 4-1 | 58-47 | 1 | 20,029 | Jim Palmer | Bill Lee | Jim Palmer | Bill Lee | | 439 | 360 | 79 |
| 1973-08-05 | vs BOS | 106 | L 4-7 | 58-48 | 1 | 15,175 | Mike Cuellar | John Curtis | John Curtis | Mike Cuellar | | 443 | 367 | 76 |
| 1973-08-06 | vs BOS | 107 | L 3-5 | 58-49 | 2 | 12,197 | Doyle Alexander | Roger Moret | Roger Moret | Doyle Alexander | Bobby Bolin | 446 | 372 | 74 |
| 1973-08-07 | @ MIN | 108 | L 2-4 | 59-50 | 2 | 0 | Jesse Jefferson | Joe Decker | Joe Decker | Jesse Jefferson | Eddie Bane | 448 | 376 | 72 |
| 1973-08-07 | @ MIN | 109 | W 10-4 | 59-50 | 2 | 15,176 | Dave McNally | Jim Kaat | Dave McNally | Jim Kaat | Bob Reynolds | 458 | 380 | 78 |
| 1973-08-08 | @ MIN | 110 | W 6-1 | 60-50 | 2 | 13,502 | Jim Palmer | Dick Woodson | Jim Palmer | Dick Woodson | | 464 | 381 | 83 |
| 1973-08-09 | @ MIN | 111 | W 2-1 | 61-50 | 1 | 11,071 | Mike Cuellar | Bert Blyleven | Mike Cuellar | Bert Blyleven | | 466 | 382 | 84 |
| 1973-08-10 | @ KCA | 112 | L 1-2 | 61-51 | 2 | 22,294 | Doyle Alexander | Al Fitzmorris | Al Fitzmorris | Doyle Alexander | Doug Bird | 467 | 384 | 83 |
| 1973-08-11 | @ KCA | 113 | L 4-9 | 61-52 | 2 | 37,010 | Dave McNally | Paul Splittorff | Paul Splittorff | Dave McNally | | 471 | 393 | 78 |
| 1973-08-12 | @ KCA | 114 | W 10-6 | 62-52 | 2 | 22,089 | Jim Palmer | Dick Drago | Jim Palmer | Dick Drago | Bob Reynolds | 481 | 399 | 82 |
| 1973-08-13 | @ TEX | 115 | W 7-4 | 63-52 | 2 | 4,709 | Mike Cuellar | Jim Merritt | Mike Cuellar | Jim Merritt | | 488 | 403 | 85 |
| 1973-08-14 | @ TEX | 116 | W 12-10 | 64-52 | 2 | 5,261 | Doyle Alexander | Sonny Siebert | Grant Jackson | Sonny Siebert | | 500 | 413 | 87 |
| 1973-08-15 | @ TEX | 117 | W 5-1 | 65-52 | 1 | 8,033 | Dave McNally | Jim Bibby | Dave McNally | Jim Bibby | | 505 | 414 | 91 |
| 1973-08-17 | vs CHA | 118 | W 3-2 | 66-52 | 1 | 14,401 | Jim Palmer | Stan Bahnsen | Jim Palmer | Stan Bahnsen | Grant Jackson | 508 | 416 | 92 |
| 1973-08-18 | vs CHA | 119 | W 3-0 | 67-52 | 1 | 30,514 | Mike Cuellar | Terry Forster | Mike Cuellar | Terry Forster | | 511 | 416 | 95 |
| 1973-08-19 | vs CHA | 120 | W 8-2 | 68-52 | 1 | 14,345 | Dave McNally | Wilbur Wood | Dave McNally | Wilbur Wood | | 519 | 418 | 101 |
| 1973-08-20 | vs MIN | 121 | W 4-3 | 69-52 | 1 | 8,134 | Doyle Alexander | Ray Corbin | Doyle Alexander | Bill Hands | | 523 | 421 | 102 |
| 1973-08-21 | vs MIN | 122 | W 2-1 | 70-52 | 1 | 8,829 | Jim Palmer | Bert Blyleven | Grant Jackson | Bert Blyleven | | 525 | 422 | 103 |
| 1973-08-22 | vs MIN | 123 | W 4-3 | 71-52 | 1 | 12,063 | Mike Cuellar | Bill Campbell | Mike Cuellar | Danny Fife | Bob Reynolds | 529 | 425 | 104 |
| 1973-08-24 | vs KCA | 124 | W 6-0 | 72-52 | 1 | 17,058 | Dave McNally | Al Fitzmorris | Dave McNally | Al Fitzmorris | | 535 | 425 | 110 |
| 1973-08-25 | vs KCA | 125 | W 7-1 | 73-52 | 1 | 15,604 | Doyle Alexander | Steve Busby | Doyle Alexander | Steve Busby | | 542 | 426 | 116 |
| 1973-08-26 | vs KCA | 126 | W 10-1 | 74-52 | 1 | 15,285 | Jim Palmer | Paul Splittorff | Jim Palmer | Paul Splittorff | Eddie Watt | 552 | 427 | 125 |
| 1973-08-27 | vs TEX | 127 | W 6-1 | 75-52 | 1 | 12,477 | Mike Cuellar | David Clyde | Mike Cuellar | David Clyde | | 558 | 428 | 130 |
| 1973-08-28 | vs TEX | 128 | L 3-5 | 75-53 | 1 | 10,524 | Dave McNally | Charlie Hudson | Charlie Hudson | Dave McNally | Sonny Siebert | 561 | 433 | 128 |
| 1973-08-29 | vs TEX | 129 | W 6-1 | 76-53 | 1 | 9,845 | Doyle Alexander | Don Durham | Doyle Alexander | Don Durham | | 567 | 434 | 133 |
| 1973-08-31 | @ NYA | 130 | L 2-5 | 76-54 | 1 | 20,499 | Jim Palmer | Mel Stottlemyre | Mel Stottlemyre | Jim Palmer | | 569 | 439 | 130 |
| 1973-09-01 | @ NYA | 131 | W 10-6 | 77-54 | 1 | 25,702 | Mike Cuellar | Pat Dobson | Mike Cuellar | Pat Dobson | Don Hood | 579 | 445 | 134 |
| 1973-09-02 | @ NYA | 132 | W 1-0 | 78-54 | 1 | 18,078 | Dave McNally | Sam McDowell | Dave McNally | Sam McDowell | | 580 | 445 | 135 |
| 1973-09-03 | @ BOS | 133 | W 13-8 | 79-55 | 1 | 27,730 | Doyle Alexander | John Curtis | Doyle Alexander | John Curtis | Eddie Watt | 593 | 453 | 140 |
| 1973-09-03 | @ BOS | 134 | L 8-9 | 79-55 | 1 | 22,267 | Jesse Jefferson | Dick Pole | Bob Veale | Eddie Watt | | 601 | 462 | 139 |
| 1973-09-04 | @ BOS | 135 | L 1-2 | 79-56 | 1 | 18,808 | Jim Palmer | Luis Tiant | Luis Tiant | Jim Palmer | | 602 | 464 | 138 |
| 1973-09-05 | @ BOS | 136 | L 5-7 | 79-57 | 1 | 21,758 | Mike Cuellar | Roger Moret | Roger Moret | Mike Cuellar | Bobby Bolin | 607 | 471 | 136 |
| 1973-09-07 | @ CLE | 137 | W 7-3 | 80-57 | 1 | 5,160 | Dave McNally | Gaylord Perry | Dave McNally | Gaylord Perry | | 614 | 474 | 140 |
| 1973-09-08 | @ CLE | 138 | W 6-1 | 81-57 | 1 | 3,851 | Jim Palmer | Milt Wilcox | Jim Palmer | Milt Wilcox | | 620 | 475 | 145 |
| 1973-09-09 | @ CLE | 139 | L 4-6 | 82-58 | 1 | 0 | Doyle Alexander | Brent Strom | Ray Lamb | Doyle Alexander | | 624 | 481 | 143 |
| 1973-09-09 | @ CLE | 140 | W 13-4 | 82-58 | 1 | 7,120 | Mike Cuellar | Tom Timmermann | Mike Cuellar | Tom Timmermann | Eddie Watt | 637 | 485 | 152 |
| 1973-09-10 | vs BOS | 141 | L 3-4 | 82-59 | 1 | 18,577 | Jesse Jefferson | Luis Tiant | Luis Tiant | Jesse Jefferson | Bobby Bolin | 640 | 489 | 151 |
| 1973-09-11 | vs BOS | 142 | W 8-3 | 83-59 | 1 | 17,278 | Dave McNally | Marty Pattin | Dave McNally | Marty Pattin | Bob Reynolds | 648 | 492 | 156 |
| 1973-09-12 | vs MIL | 143 | W 4-1 | 85-59 | 1 | 0 | Jim Palmer | Skip Lockwood | Jim Palmer | Skip Lockwood | | 652 | 493 | 159 |
| 1973-09-12 | vs MIL | 144 | W 5-3 | 85-59 | 1 | 7,203 | Don Hood | Jerry Bell | Grant Jackson | Jerry Bell | | 657 | 496 | 161 |
| 1973-09-13 | vs MIL | 145 | W 7-6 | 86-59 | 1 | 5,001 | Mike Cuellar | Bill Champion | Bob Reynolds | Ed Sprague | | 664 | 502 | 162 |
| 1973-09-15 | vs NYA | 146 | L 0-3 | 86-60 | 1 | 23,765 | Dave McNally | Mel Stottlemyre | Mel Stottlemyre | Dave McNally | | 664 | 505 | 159 |
| 1973-09-16 | vs NYA | 147 | W 3-0 | 87-61 | 1 | 0 | Jim Palmer | Fritz Peterson | Jim Palmer | Fritz Peterson | | 667 | 505 | 162 |
| 1973-09-16 | vs NYA | 148 | L 5-7 | 87-61 | 1 | 22,958 | Doyle Alexander | Pat Dobson | Pat Dobson | Doyle Alexander | Sparky Lyle | 672 | 512 | 160 |
| 1973-09-17 | vs NYA | 149 | W 5-4 | 88-61 | 1 | 6,114 | Mike Cuellar | Lindy McDaniel | Mike Cuellar | Wayne Granger | | 677 | 516 | 161 |
| 1973-09-18 | @ DET | 150 | W 6-2 | 89-61 | 1 | 12,845 | Jesse Jefferson | Mickey Lolich | Jesse Jefferson | Mickey Lolich | | 683 | 518 | 165 |
| 1973-09-19 | @ DET | 151 | L 1-10 | 89-62 | 1 | 12,339 | Dave McNally | Joe Coleman | Joe Coleman | Dave McNally | John Hiller | 684 | 528 | 156 |
| 1973-09-20 | @ DET | 152 | W 9-0 | 90-62 | 1 | 10,529 | Jim Palmer | Woodie Fryman | Jim Palmer | Woodie Fryman | | 693 | 528 | 165 |
| 1973-09-21 | @ MIL | 153 | W 7-4 | 91-62 | 1 | 6,795 | Mike Cuellar | Bill Champion | Mike Cuellar | Bill Champion | Bob Reynolds | 700 | 532 | 168 |
| 1973-09-22 | @ MIL | 154 | W 7-1 | 92-62 | 1 | 9,919 | Doyle Alexander | Jim Colborn | Doyle Alexander | Jim Colborn | | 707 | 533 | 174 |
| 1973-09-23 | @ MIL | 155 | W 2-1 | 93-62 | 1 | 5,962 | Dave McNally | Jim Slaton | Dave McNally | Jim Slaton | Eddie Watt | 709 | 534 | 175 |
| 1973-09-25 | vs DET | 156 | W 8-3 | 94-62 | 1 | 8,176 | Jesse Jefferson | Jim Perry | Jesse Jefferson | Jim Perry | Grant Jackson | 717 | 537 | 180 |
| 1973-09-26 | vs DET | 157 | W 4-0 | 95-62 | 1 | 5,380 | Don Hood | Mickey Lolich | Don Hood | Mickey Lolich | | 721 | 537 | 184 |
| 1973-09-27 | vs DET | 158 | L 2-5 | 95-63 | 1 | 4,719 | Wayne Garland | Joe Coleman | Joe Coleman | Wayne Garland | | 723 | 542 | 181 |
| 1973-09-28 | vs CLE | 159 | L 4-6 | 96-64 | 1 | 0 | Jim Palmer | Dick Tidrow | Dick Tidrow | Jim Palmer | Ken Sanders | 727 | 548 | 179 |
| 1973-09-28 | vs CLE | 160 | W 18-4 | 96-64 | 1 | 9,630 | Doyle Alexander | Milt Wilcox | Doyle Alexander | Milt Wilcox | Grant Jackson | 745 | 552 | 193 |
| 1973-09-29 | vs CLE | 161 | L 2-6 | 97-65 | 1 | 0 | Dave McNally | Tom Timmermann | Tom Timmermann | Dave McNally | | 747 | 558 | 189 |
| 1973-09-29 | vs CLE | 162 | W 7-3 | 97-65 | 1 | 6,598 | Mike Cuellar | Mike Kekich | Mike Cuellar | Mike Kekich | | 754 | 561 | 193 |