| 1973-04-06 | vs KCA | 1 | W 3-2 | 1-0 | 2 | 27,240 | Nolan Ryan | Steve Busby | Nolan Ryan | Steve Busby | | 3 | 2 | 1 |
| 1973-04-07 | vs KCA | 2 | L 5-12 | 1-1 | 4 | 17,151 | Clyde Wright | Wayne Simpson | Wayne Simpson | Clyde Wright | | 8 | 14 | -6 |
| 1973-04-08 | vs KCA | 3 | L 5-6 | 1-2 | 4 | 7,390 | Rudy May | Dick Drago | Dick Drago | Rudy May | Bruce Dal Canton | 13 | 20 | -7 |
| 1973-04-10 | vs MIN | 4 | W 4-2 | 2-2 | 4 | 6,319 | Bill Singer | Bert Blyleven | Bill Singer | Bert Blyleven | | 17 | 22 | -5 |
| 1973-04-11 | vs MIN | 5 | W 4-1 | 3-2 | 3 | 6,946 | Nolan Ryan | Bill Hands | Nolan Ryan | Bill Hands | | 21 | 23 | -2 |
| 1973-04-13 | @ TEX | 6 | L 2-4 | 3-3 | 4 | 11,047 | Clyde Wright | Mike Paul | Mike Paul | Clyde Wright | Steve Foucault | 23 | 27 | -4 |
| 1973-04-17 | @ MIN | 7 | L 5-10 | 3-4 | 4 | 3,856 | Bill Singer | Jim Kaat | Jim Kaat | Bill Singer | Ken Sanders | 28 | 37 | -9 |
| 1973-04-18 | @ MIN | 8 | W 3-2 | 4-4 | 4 | 5,088 | Nolan Ryan | Bert Blyleven | Nolan Ryan | Bert Blyleven | | 31 | 39 | -8 |
| 1973-04-20 | @ OAK | 9 | L 3-4 | 4-5 | 4 | 6,142 | Clyde Wright | Ken Holtzman | Ken Holtzman | Clyde Wright | | 34 | 43 | -9 |
| 1973-04-21 | @ OAK | 10 | W 4-2 | 5-5 | 4 | 7,161 | Bill Singer | Vida Blue | Bill Singer | Vida Blue | Lloyd Allen | 38 | 45 | -7 |
| 1973-04-22 | @ OAK | 11 | L 2-3 | 5-6 | 4 | 7,442 | Nolan Ryan | Catfish Hunter | Horacio Pina | Ron Perranoski | | 40 | 48 | -8 |
| 1973-04-23 | @ OAK | 12 | W 4-0 | 6-6 | 4 | 14,752 | Rudy May | Blue Moon Odom | Rudy May | Blue Moon Odom | | 44 | 48 | -4 |
| 1973-04-24 | vs BAL | 13 | W 6-5 | 7-6 | 4 | 7,488 | Clyde Wright | Doyle Alexander | Dave Sells | Eddie Watt | | 50 | 53 | -3 |
| 1973-04-25 | vs BAL | 14 | W 1-0 | 8-6 | 4 | 7,061 | Bill Singer | Dave McNally | Bill Singer | Dave McNally | | 51 | 53 | -2 |
| 1973-04-27 | vs CLE | 15 | L 2-6 | 8-7 | 4 | 32,321 | Nolan Ryan | Milt Wilcox | Milt Wilcox | Nolan Ryan | | 53 | 59 | -6 |
| 1973-04-28 | vs CLE | 16 | W 5-0 | 9-7 | 4 | 8,732 | Rudy May | Gaylord Perry | Rudy May | Gaylord Perry | | 58 | 59 | -1 |
| 1973-04-29 | vs CLE | 17 | L 2-3 | 9-8 | 4 | 13,244 | Clyde Wright | Dick Tidrow | Dick Tidrow | Clyde Wright | | 60 | 62 | -2 |
| 1973-05-01 | @ DET | 18 | W 6-2 | 10-8 | 3 | 10,118 | Bill Singer | Woodie Fryman | Bill Singer | Woodie Fryman | | 66 | 64 | 2 |
| 1973-05-02 | @ DET | 19 | W 5-3 | 11-8 | 3 | 10,003 | Nolan Ryan | Mickey Lolich | Nolan Ryan | Lerrin LaGrow | | 71 | 67 | 4 |
| 1973-05-04 | @ BAL | 20 | W 1-0 | 12-8 | 3 | 14,392 | Rudy May | Dave McNally | Rudy May | Dave McNally | | 72 | 67 | 5 |
| 1973-05-05 | @ BAL | 21 | W 3-1 | 13-8 | 3 | 7,177 | Bill Singer | Mike Cuellar | Bill Singer | Mike Cuellar | | 75 | 68 | 7 |
| 1973-05-06 | @ BAL | 22 | L 0-5 | 13-9 | 3 | 11,282 | Nolan Ryan | Jim Palmer | Jim Palmer | Nolan Ryan | | 75 | 73 | 2 |
| 1973-05-08 | @ CLE | 23 | L 0-2 | 13-10 | 3 | 1,437 | Clyde Wright | Gaylord Perry | Gaylord Perry | Clyde Wright | | 75 | 75 | 0 |
| 1973-05-09 | @ CLE | 24 | L 3-10 | 13-11 | 3 | 2,536 | Rudy May | Milt Wilcox | Milt Wilcox | Rudy May | Jerry Johnson | 78 | 85 | -7 |
| 1973-05-10 | vs CHA | 25 | L 3-4 | 13-12 | 3 | 9,414 | Bill Singer | Wilbur Wood | Wilbur Wood | Ron Perranoski | Terry Forster | 81 | 89 | -8 |
| 1973-05-11 | vs CHA | 26 | L 4-7 | 13-13 | 4 | 11,716 | Nolan Ryan | Stan Bahnsen | Stan Bahnsen | Nolan Ryan | Terry Forster | 85 | 96 | -11 |
| 1973-05-12 | vs CHA | 27 | W 6-5 | 14-13 | 4 | 25,655 | Clyde Wright | Eddie Fisher | Dave Sells | Steve Stone | Nolan Ryan | 91 | 101 | -10 |
| 1973-05-13 | vs CHA | 28 | W 3-0 | 15-13 | 3 | 11,155 | Rudy May | Rich Gossage | Rudy May | Rich Gossage | | 94 | 101 | -7 |
| 1973-05-14 | @ KCA | 29 | W 3-2 | 16-13 | 3 | 10,053 | Bill Singer | Dick Drago | Bill Singer | Dick Drago | | 97 | 103 | -6 |
| 1973-05-15 | @ KCA | 30 | W 3-0 | 17-13 | 3 | 12,205 | Nolan Ryan | Bruce Dal Canton | Nolan Ryan | Bruce Dal Canton | | 100 | 103 | -3 |
| 1973-05-16 | vs OAK | 31 | W 7-2 | 18-13 | 2 | 11,087 | Clyde Wright | Blue Moon Odom | Clyde Wright | Blue Moon Odom | | 107 | 105 | 2 |
| 1973-05-17 | vs OAK | 32 | L 0-4 | 18-14 | 3 | 11,481 | Rudy May | Catfish Hunter | Catfish Hunter | Rudy May | | 107 | 109 | -2 |
| 1973-05-18 | vs TEX | 33 | W 7-1 | 19-14 | 2 | 13,926 | Bill Singer | Mike Paul | Bill Singer | Mike Paul | | 114 | 110 | 4 |
| 1973-05-19 | vs TEX | 34 | W 9-1 | 20-14 | 2 | 15,019 | Nolan Ryan | Rich Hand | Nolan Ryan | Rich Hand | | 123 | 111 | 12 |
| 1973-05-20 | vs TEX | 35 | W 4-2 | 21-14 | 2 | 15,689 | Clyde Wright | Don Stanhouse | Clyde Wright | Don Stanhouse | Dave Sells | 127 | 113 | 14 |
| 1973-05-22 | @ CHA | 36 | L 2-6 | 21-15 | 2 | 7,051 | Rudy May | Stan Bahnsen | Stan Bahnsen | Rudy May | | 129 | 119 | 10 |
| 1973-05-23 | @ CHA | 37 | L 3-5 | 21-16 | 2 | 9,480 | Bill Singer | Eddie Fisher | Terry Forster | Bill Singer | | 132 | 124 | 8 |
| 1973-05-24 | @ CHA | 38 | L 1-4 | 21-17 | 3 | 17,727 | Nolan Ryan | Wilbur Wood | Wilbur Wood | Nolan Ryan | Cy Acosta | 133 | 128 | 5 |
| 1973-05-25 | @ MIL | 39 | W 5-3 | 22-17 | 2 | 9,089 | Clyde Wright | Bill Parsons | Clyde Wright | Bill Parsons | Steve Barber | 138 | 131 | 7 |
| 1973-05-26 | @ MIL | 40 | L 0-9 | 22-18 | 2 | 7,069 | Rudy May | Jim Colborn | Jim Colborn | Rudy May | | 138 | 140 | -2 |
| 1973-05-28 | @ MIL | 41 | W 7-4 | 23-18 | 2 | 12,415 | Bill Singer | Jerry Bell | Bill Singer | Jerry Bell | | 145 | 144 | 1 |
| 1973-05-29 | @ BOS | 42 | L 1-2 | 23-19 | 3 | 12,691 | Nolan Ryan | Bill Lee | Bill Lee | Nolan Ryan | Bobby Bolin | 146 | 146 | 0 |
| 1973-05-30 | @ BOS | 43 | L 1-2 | 23-20 | 3 | 11,809 | Clyde Wright | Luis Tiant | Luis Tiant | Clyde Wright | | 147 | 148 | -1 |
| 1973-05-31 | @ BOS | 44 | W 7-6 | 24-20 | 3 | 10,600 | Rudy May | John Curtis | Rich Hand | Bobby Bolin | Dave Sells | 154 | 154 | 0 |
| 1973-06-01 | @ NYA | 45 | W 5-2 | 25-20 | 3 | 12,060 | Bill Singer | Mike Kekich | Bill Singer | Mike Kekich | Dave Sells | 159 | 156 | 3 |
| 1973-06-02 | @ NYA | 46 | L 0-2 | 25-21 | 4 | 13,831 | Nolan Ryan | Fritz Peterson | Fritz Peterson | Nolan Ryan | Sparky Lyle | 159 | 158 | 1 |
| 1973-06-03 | @ NYA | 47 | L 2-3 | 25-22 | 4 | 60,108 | Clyde Wright | Doc Medich | Doc Medich | Clyde Wright | Sparky Lyle | 161 | 161 | 0 |
| 1973-06-05 | vs DET | 48 | L 2-5 | 25-23 | 4 | 9,777 | Rich Hand | Jim Perry | Jim Perry | Rich Hand | John Hiller | 163 | 166 | -3 |
| 1973-06-06 | vs DET | 49 | W 7-4 | 26-23 | 4 | 11,691 | Bill Singer | Joe Coleman | Bill Singer | Joe Coleman | Dave Sells | 170 | 170 | 0 |
| 1973-06-07 | vs DET | 50 | W 3-0 | 27-23 | 3 | 13,807 | Nolan Ryan | Woodie Fryman | Nolan Ryan | Woodie Fryman | | 173 | 170 | 3 |
| 1973-06-08 | vs MIL | 51 | L 2-8 | 27-24 | 3 | 11,497 | Clyde Wright | Jerry Bell | Jerry Bell | Clyde Wright | | 175 | 178 | -3 |
| 1973-06-09 | vs MIL | 52 | L 0-1 | 27-25 | 3 | 22,576 | Rudy May | Jim Colborn | Jim Colborn | Rudy May | Frank Linzy | 175 | 179 | -4 |
| 1973-06-10 | vs MIL | 53 | L 6-8 | 27-26 | 4 | 16,279 | Bill Singer | Jim Slaton | Jim Slaton | Bill Singer | Frank Linzy | 181 | 187 | -6 |
| 1973-06-12 | vs BOS | 54 | L 5-6 | 27-27 | 5 | 11,120 | Nolan Ryan | Luis Tiant | Luis Tiant | Nolan Ryan | Bobby Bolin | 186 | 193 | -7 |
| 1973-06-13 | vs BOS | 55 | W 7-5 | 28-27 | 4 | 8,775 | Clyde Wright | Ray Culp | Clyde Wright | Ray Culp | Dave Sells | 193 | 198 | -5 |
| 1973-06-14 | vs BOS | 56 | W 5-3 | 29-27 | 3 | 10,216 | Rudy May | John Curtis | Rudy May | John Curtis | Dave Sells | 198 | 201 | -3 |
| 1973-06-15 | vs NYA | 57 | L 3-4 | 29-28 | 5 | 15,525 | Bill Singer | Mel Stottlemyre | Mel Stottlemyre | Dave Sells | Sparky Lyle | 201 | 205 | -4 |
| 1973-06-16 | vs NYA | 58 | W 5-2 | 30-28 | 5 | 15,134 | Nolan Ryan | Pat Dobson | Nolan Ryan | Pat Dobson | | 206 | 207 | -1 |
| 1973-06-17 | vs NYA | 59 | W 8-0 | 31-29 | 5 | 0 | Clyde Wright | Fritz Peterson | Clyde Wright | Fritz Peterson | | 214 | 207 | 7 |
| 1973-06-17 | vs NYA | 60 | L 1-5 | 31-29 | 5 | 28,857 | Rich Hand | Sam McDowell | Sam McDowell | Rich Hand | Sparky Lyle | 215 | 212 | 3 |
| 1973-06-18 | @ CHA | 61 | W 9-2 | 32-29 | 5 | 10,443 | Rudy May | Eddie Fisher | Rudy May | Eddie Fisher | | 224 | 214 | 10 |
| 1973-06-19 | @ CHA | 62 | W 3-1 | 33-29 | 4 | 11,926 | Bill Singer | Wilbur Wood | Bill Singer | Wilbur Wood | | 227 | 215 | 12 |
| 1973-06-20 | @ CHA | 63 | L 3-8 | 33-30 | 5 | 19,142 | Nolan Ryan | Steve Stone | Cy Acosta | Nolan Ryan | | 230 | 223 | 7 |
| 1973-06-21 | @ MIN | 64 | L 0-1 | 33-31 | 5 | 8,819 | Clyde Wright | Bert Blyleven | Bert Blyleven | Clyde Wright | | 230 | 224 | 6 |
| 1973-06-22 | @ MIN | 65 | W 4-3 | 34-31 | 5 | 14,237 | Rudy May | Joe Decker | Dave Sells | Joe Decker | | 234 | 227 | 7 |
| 1973-06-23 | @ MIN | 66 | W 3-1 | 35-31 | 5 | 11,631 | Bill Singer | Jim Kaat | Rich Hand | Jim Kaat | | 237 | 228 | 9 |
| 1973-06-24 | @ MIN | 67 | L 1-5 | 36-32 | 5 | 0 | Andy Hassler | Dick Woodson | Dick Woodson | Andy Hassler | Ray Corbin | 238 | 233 | 5 |
| 1973-06-24 | @ MIN | 68 | W 3-0 | 36-32 | 5 | 20,153 | Clyde Wright | Dave Goltz | Clyde Wright | Ray Corbin | Steve Barber | 241 | 233 | 8 |
| 1973-06-25 | vs KCA | 69 | W 5-2 | 37-32 | 3 | 18,048 | Nolan Ryan | Ken Wright | Nolan Ryan | Ken Wright | | 246 | 235 | 11 |
| 1973-06-26 | vs KCA | 70 | W 6-5 | 38-32 | 1 | 10,691 | Rudy May | Dick Drago | Dave Sells | Dick Drago | | 252 | 240 | 12 |
| 1973-06-27 | vs CHA | 71 | W 3-1 | 39-32 | 1 | 18,178 | Bill Singer | Bart Johnson | Bill Singer | Bart Johnson | | 255 | 241 | 14 |
| 1973-06-28 | vs CHA | 72 | L 0-2 | 39-33 | 2 | 14,175 | Clyde Wright | Steve Stone | Steve Stone | Clyde Wright | Terry Forster | 255 | 243 | 12 |
| 1973-06-29 | vs MIN | 73 | L 0-4 | 39-34 | 4 | 15,212 | Nolan Ryan | Bert Blyleven | Bert Blyleven | Nolan Ryan | | 255 | 247 | 8 |
| 1973-06-30 | vs MIN | 74 | L 3-6 | 39-35 | 4 | 25,017 | Andy Hassler | Joe Decker | Joe Decker | Andy Hassler | Ray Corbin | 258 | 253 | 5 |
| 1973-07-01 | vs MIN | 75 | L 1-2 | 39-36 | 4 | 27,068 | Bill Singer | Jim Kaat | Jim Kaat | Bill Singer | | 259 | 255 | 4 |
| 1973-07-02 | @ OAK | 76 | W 4-2 | 40-36 | 4 | 33,407 | Clyde Wright | Vida Blue | Clyde Wright | Vida Blue | Steve Barber | 263 | 257 | 6 |
| 1973-07-03 | @ OAK | 77 | L 0-3 | 40-37 | 4 | 7,104 | Nolan Ryan | Ken Holtzman | Ken Holtzman | Nolan Ryan | | 263 | 260 | 3 |
| 1973-07-04 | @ OAK | 78 | W 3-1 | 41-37 | 4 | 36,741 | Bill Singer | Dave Hamilton | Bill Singer | Dave Hamilton | Dave Sells | 266 | 261 | 5 |
| 1973-07-06 | @ CLE | 79 | L 7-8 | 41-38 | 5 | 6,699 | Clyde Wright | Dick Tidrow | Jerry Johnson | Steve Barber | | 273 | 269 | 4 |
| 1973-07-07 | @ CLE | 80 | W 3-1 | 42-38 | 4 | 7,553 | Nolan Ryan | Gaylord Perry | Nolan Ryan | Gaylord Perry | Steve Barber | 276 | 270 | 6 |
| 1973-07-08 | @ CLE | 81 | W 10-4 | 44-38 | 2 | 0 | Bill Singer | Milt Wilcox | Bill Singer | Milt Wilcox | | 286 | 274 | 12 |
| 1973-07-08 | @ CLE | 82 | W 5-3 | 44-38 | 2 | 12,147 | Dick Lange | Dick Bosman | Steve Barber | Jerry Johnson | Dave Sells | 291 | 277 | 14 |
| 1973-07-09 | @ BAL | 83 | L 3-5 | 44-39 | 3 | 8,677 | Clyde Wright | Dave McNally | Dave McNally | Clyde Wright | Bob Reynolds | 294 | 282 | 12 |
| 1973-07-10 | @ BAL | 84 | W 10-8 | 45-39 | 3 | 9,649 | Rudy May | Jim Palmer | Dick Lange | Eddie Watt | | 304 | 290 | 14 |
| 1973-07-11 | @ BAL | 85 | L 1-7 | 45-40 | 3 | 9,389 | Nolan Ryan | Mike Cuellar | Mike Cuellar | Nolan Ryan | | 305 | 297 | 8 |
| 1973-07-12 | @ DET | 86 | L 6-7 | 45-41 | 4 | 15,513 | Bill Singer | Mike Strahler | John Hiller | Dave Sells | | 311 | 304 | 7 |
| 1973-07-13 | @ DET | 87 | L 2-8 | 45-42 | 5 | 26,646 | Clyde Wright | Mickey Lolich | Mickey Lolich | Clyde Wright | | 313 | 312 | 1 |
| 1973-07-14 | @ DET | 88 | L 1-2 | 45-43 | 5 | 28,253 | Rudy May | Joe Coleman | Joe Coleman | Rudy May | | 314 | 314 | 0 |
| 1973-07-15 | @ DET | 89 | W 6-0 | 46-43 | 4 | 41,411 | Nolan Ryan | Jim Perry | Nolan Ryan | Jim Perry | | 320 | 314 | 6 |
| 1973-07-16 | vs CLE | 90 | L 8-9 | 46-44 | 4 | 20,265 | Bill Singer | Milt Wilcox | Milt Wilcox | Bill Singer | Tom Timmermann | 328 | 323 | 5 |
| 1973-07-17 | vs CLE | 91 | W 3-1 | 47-44 | 3 | 10,968 | Clyde Wright | Dick Bosman | Clyde Wright | Dick Bosman | | 331 | 324 | 7 |
| 1973-07-18 | vs CLE | 92 | L 8-10 | 47-45 | 4 | 10,005 | Rudy May | Dick Tidrow | Tom Hilgendorf | Steve Barber | | 339 | 334 | 5 |
| 1973-07-19 | vs BAL | 93 | L 1-3 | 47-46 | 5 | 20,823 | Nolan Ryan | Mike Cuellar | Mike Cuellar | Nolan Ryan | | 340 | 337 | 3 |
| 1973-07-20 | vs BAL | 94 | W 8-3 | 48-46 | 4 | 40,257 | Bill Singer | Jesse Jefferson | Bill Singer | Jesse Jefferson | | 348 | 340 | 8 |
| 1973-07-21 | vs BAL | 95 | L 3-5 | 48-47 | 4 | 14,931 | Clyde Wright | Dave McNally | Dave McNally | Clyde Wright | Grant Jackson | 351 | 345 | 6 |
| 1973-07-22 | vs BAL | 96 | L 2-8 | 48-48 | 5 | 11,743 | Rudy May | Jim Palmer | Jim Palmer | Rudy May | | 353 | 353 | 0 |
| 1973-07-26 | @ TEX | 97 | L 1-7 | 48-50 | 5 | 0 | Nolan Ryan | Jim Bibby | Jim Bibby | Nolan Ryan | | 354 | 360 | -6 |
| 1973-07-26 | @ TEX | 98 | L 0-8 | 48-50 | 5 | 25,620 | Bill Singer | David Clyde | David Clyde | Bill Singer | Jackie Brown | 354 | 368 | -14 |
| 1973-07-27 | @ TEX | 99 | L 2-5 | 48-51 | 5 | 3,317 | Clyde Wright | Jim Merritt | Jim Merritt | Clyde Wright | | 356 | 373 | -17 |
| 1973-07-28 | @ KCA | 100 | W 19-8 | 49-51 | 5 | 14,228 | Rudy May | Ken Wright | Aurelio Monteagudo | Ken Wright | | 375 | 381 | -6 |
| 1973-07-29 | @ KCA | 101 | L 0-7 | 49-53 | 5 | 0 | Bill Singer | Al Fitzmorris | Al Fitzmorris | Bill Singer | | 375 | 388 | -13 |
| 1973-07-29 | @ KCA | 102 | L 6-7 | 49-53 | 5 | 23,306 | Nolan Ryan | Dick Drago | Joe Hoerner | Rudy May | | 381 | 395 | -14 |
| 1973-07-31 | vs TEX | 103 | L 2-4 | 49-54 | 5 | 11,147 | Clyde Wright | David Clyde | David Clyde | Clyde Wright | Don Durham | 383 | 399 | -16 |
| 1973-08-01 | vs TEX | 104 | W 5-1 | 50-54 | 5 | 8,087 | Rudy May | Jim Merritt | Rudy May | Jim Merritt | | 388 | 400 | -12 |
| 1973-08-02 | vs TEX | 105 | W 3-2 | 51-54 | 5 | 7,500 | Nolan Ryan | Sonny Siebert | Nolan Ryan | Sonny Siebert | | 391 | 402 | -11 |
| 1973-08-03 | vs OAK | 106 | L 1-2 | 51-55 | 5 | 15,712 | Bill Singer | Vida Blue | Vida Blue | Bill Singer | Rollie Fingers | 392 | 404 | -12 |
| 1973-08-04 | vs OAK | 107 | L 2-3 | 51-56 | 5 | 17,945 | Clyde Wright | Ken Holtzman | Ken Holtzman | Clyde Wright | Horacio Pina | 394 | 407 | -13 |
| 1973-08-05 | vs OAK | 108 | L 2-6 | 51-57 | 5 | 13,158 | Rudy May | Darold Knowles | Rollie Fingers | Rudy May | | 396 | 413 | -17 |
| 1973-08-07 | @ MIL | 109 | W 6-5 | 52-57 | 5 | 9,493 | Nolan Ryan | Jerry Bell | Nolan Ryan | Chris Short | Aurelio Monteagudo | 402 | 418 | -16 |
| 1973-08-08 | @ MIL | 110 | L 2-8 | 52-58 | 5 | 7,046 | Bill Singer | Jim Colborn | Jim Colborn | Bill Singer | | 404 | 426 | -22 |
| 1973-08-09 | @ MIL | 111 | L 5-6 | 52-59 | 5 | 6,311 | Clyde Wright | Jim Slaton | Jim Slaton | Rudy May | | 409 | 432 | -23 |
| 1973-08-10 | @ BOS | 112 | W 5-3 | 53-59 | 5 | 24,856 | Dick Lange | John Curtis | Dave Sells | John Curtis | | 414 | 435 | -21 |
| 1973-08-11 | @ BOS | 113 | L 1-2 | 53-60 | 5 | 19,046 | Nolan Ryan | Roger Moret | Roger Moret | Nolan Ryan | Bob Veale | 415 | 437 | -22 |
| 1973-08-12 | @ BOS | 114 | L 8-14 | 53-61 | 5 | 20,522 | Bill Singer | Dick Pole | Dick Pole | Bill Singer | Bobby Bolin | 423 | 451 | -28 |
| 1973-08-13 | @ NYA | 115 | L 0-6 | 53-62 | 5 | 18,202 | Rudy May | Doc Medich | Doc Medich | Rudy May | | 423 | 457 | -34 |
| 1973-08-14 | @ NYA | 116 | L 2-7 | 53-63 | 5 | 14,098 | Clyde Wright | Pat Dobson | Lindy McDaniel | Clyde Wright | | 425 | 464 | -39 |
| 1973-08-15 | @ NYA | 117 | W 3-1 | 54-63 | 5 | 17,253 | Steve Barber | Mel Stottlemyre | Steve Barber | Mel Stottlemyre | Aurelio Monteagudo | 428 | 465 | -37 |
| 1973-08-17 | vs DET | 118 | W 10-2 | 55-63 | 5 | 16,201 | Nolan Ryan | Woodie Fryman | Nolan Ryan | Woodie Fryman | | 438 | 467 | -29 |
| 1973-08-18 | vs DET | 119 | W 4-1 | 56-63 | 5 | 12,490 | Bill Singer | Joe Coleman | Bill Singer | Joe Coleman | | 442 | 468 | -26 |
| 1973-08-19 | vs DET | 120 | L 3-4 | 56-64 | 5 | 10,289 | Clyde Wright | Mickey Lolich | John Hiller | Aurelio Monteagudo | | 445 | 472 | -27 |
| 1973-08-21 | vs MIL | 121 | L 2-6 | 56-65 | 5 | 21,549 | Nolan Ryan | Jim Colborn | Jim Colborn | Nolan Ryan | | 447 | 478 | -31 |
| 1973-08-22 | vs MIL | 122 | W 5-4 | 57-65 | 5 | 6,568 | Bill Singer | Jim Slaton | Dave Sells | Eduardo Rodriguez | | 452 | 482 | -30 |
| 1973-08-23 | vs MIL | 123 | W 6-3 | 58-65 | 4 | 7,968 | Clyde Wright | Bill Champion | Clyde Wright | Eduardo Rodriguez | Dave Sells | 458 | 485 | -27 |
| 1973-08-24 | vs BOS | 124 | L 2-3 | 58-66 | 4 | 11,334 | Dick Lange | Bill Lee | Bill Lee | Dick Lange | | 460 | 488 | -28 |
| 1973-08-25 | vs BOS | 125 | L 0-4 | 58-67 | 4 | 13,679 | Nolan Ryan | John Curtis | John Curtis | Nolan Ryan | | 460 | 492 | -32 |
| 1973-08-26 | vs BOS | 126 | W 1-0 | 59-67 | 5 | 8,132 | Bill Singer | Luis Tiant | Bill Singer | Luis Tiant | | 461 | 492 | -31 |
| 1973-08-28 | vs NYA | 127 | W 5-2 | 60-67 | 5 | 9,725 | Clyde Wright | Fritz Peterson | Clyde Wright | Fritz Peterson | | 466 | 494 | -28 |
| 1973-08-29 | vs NYA | 128 | W 5-0 | 61-67 | 3 | 12,286 | Nolan Ryan | Doc Medich | Nolan Ryan | Doc Medich | | 471 | 494 | -23 |
| 1973-08-31 | @ CHA | 129 | L 2-7 | 61-68 | 5 | 13,305 | Bill Singer | Wilbur Wood | Wilbur Wood | Bill Singer | Cy Acosta | 473 | 501 | -28 |
| 1973-09-01 | @ CHA | 130 | L 5-7 | 61-69 | 5 | 9,335 | Rudy May | Jim Kaat | Bart Johnson | Rudy May | Cy Acosta | 478 | 508 | -30 |
| 1973-09-02 | @ CHA | 131 | L 3-13 | 61-70 | 5 | 13,894 | Clyde Wright | Stan Bahnsen | Stan Bahnsen | Clyde Wright | | 481 | 521 | -40 |
| 1973-09-03 | vs OAK | 132 | W 3-1 | 62-70 | 5 | 14,182 | Nolan Ryan | Blue Moon Odom | Nolan Ryan | Blue Moon Odom | | 484 | 522 | -38 |
| 1973-09-04 | vs OAK | 133 | L 3-4 | 62-71 | 5 | 7,198 | Bill Singer | Ken Holtzman | Ken Holtzman | Bill Singer | Horacio Pina | 487 | 526 | -39 |
| 1973-09-05 | vs OAK | 134 | L 8-11 | 62-72 | 5 | 9,277 | Rudy May | Catfish Hunter | Catfish Hunter | Rudy May | Rollie Fingers | 495 | 537 | -42 |
| 1973-09-06 | vs OAK | 135 | L 4-6 | 62-73 | 5 | 26,104 | Clyde Wright | Vida Blue | Vida Blue | Clyde Wright | Paul Lindblad | 499 | 543 | -44 |
| 1973-09-08 | @ KCA | 136 | W 9-6 | 64-73 | 5 | 0 | Bill Singer | Al Fitzmorris | Aurelio Monteagudo | Steve Mingori | | 508 | 549 | -41 |
| 1973-09-08 | @ KCA | 137 | W 4-3 | 64-73 | 5 | 11,043 | Rich Hand | Paul Splittorff | Rich Hand | Paul Splittorff | Dave Sells | 512 | 552 | -40 |
| 1973-09-09 | @ KCA | 138 | L 5-9 | 64-75 | 5 | 0 | Andy Hassler | Dick Drago | Steve Mingori | Andy Hassler | Doug Bird | 517 | 561 | -44 |
| 1973-09-09 | @ KCA | 139 | L 3-6 | 64-75 | 5 | 16,636 | Frank Tanana | Mark Littell | Al Fitzmorris | Frank Tanana | | 520 | 567 | -47 |
| 1973-09-10 | vs CHA | 140 | W 7-1 | 65-75 | 5 | 8,255 | Dick Lange | Stan Bahnsen | Dick Lange | Stan Bahnsen | | 527 | 568 | -41 |
| 1973-09-11 | vs CHA | 141 | W 3-1 | 66-75 | 5 | 6,727 | Nolan Ryan | Wilbur Wood | Nolan Ryan | Wilbur Wood | | 530 | 569 | -39 |
| 1973-09-12 | vs CHA | 142 | W 6-5 | 67-75 | 5 | 6,555 | Bill Singer | Terry Forster | Bill Singer | Terry Forster | | 536 | 574 | -38 |
| 1973-09-13 | vs KCA | 143 | L 4-5 | 67-76 | 5 | 4,482 | Rich Hand | Al Fitzmorris | Al Fitzmorris | Rich Hand | Doug Bird | 540 | 579 | -39 |
| 1973-09-14 | vs KCA | 144 | W 3-2 | 68-76 | 5 | 5,693 | Frank Tanana | Steve Busby | Frank Tanana | Steve Busby | | 543 | 581 | -38 |
| 1973-09-15 | vs KCA | 145 | W 3-1 | 69-76 | 5 | 19,183 | Nolan Ryan | Gene Garber | Nolan Ryan | Gene Garber | | 546 | 582 | -36 |
| 1973-09-16 | vs KCA | 146 | L 0-4 | 69-77 | 5 | 5,014 | Bill Singer | Paul Splittorff | Paul Splittorff | Bill Singer | | 546 | 586 | -40 |
| 1973-09-17 | @ OAK | 147 | L 2-3 | 69-78 | 5 | 12,953 | Rudy May | Ken Holtzman | Rollie Fingers | Rudy May | | 548 | 589 | -41 |
| 1973-09-18 | @ OAK | 148 | L 4-5 | 69-79 | 5 | 3,781 | Andy Hassler | Catfish Hunter | Catfish Hunter | Andy Hassler | Rollie Fingers | 552 | 594 | -42 |
| 1973-09-19 | @ TEX | 149 | W 6-2 | 71-79 | 5 | 0 | Nolan Ryan | Pete Broberg | Nolan Ryan | Pete Broberg | | 558 | 596 | -38 |
| 1973-09-19 | @ TEX | 150 | W 9-4 | 71-79 | 5 | 3,347 | Clyde Wright | Charlie Hudson | Clyde Wright | Charlie Hudson | | 567 | 600 | -33 |
| 1973-09-20 | @ TEX | 151 | W 6-4 | 72-80 | 5 | 0 | Bill Singer | Bill Gogolewski | Bill Singer | Jim Merritt | | 573 | 604 | -31 |
| 1973-09-20 | @ TEX | 152 | L 3-8 | 72-80 | 5 | 2,583 | Frank Tanana | Steve Dunning | Steve Dunning | Frank Tanana | Steve Foucault | 576 | 612 | -36 |
| 1973-09-21 | @ TEX | 153 | W 6-1 | 73-80 | 5 | 2,513 | Rich Hand | David Clyde | Rich Hand | David Clyde | Aurelio Monteagudo | 582 | 613 | -31 |
| 1973-09-22 | @ MIN | 154 | L 3-6 | 73-81 | 5 | 6,665 | Rudy May | Bert Blyleven | Bert Blyleven | Rudy May | | 585 | 619 | -34 |
| 1973-09-23 | @ MIN | 155 | W 15-7 | 74-81 | 5 | 5,426 | Nolan Ryan | Joe Decker | Nolan Ryan | Joe Decker | | 600 | 626 | -26 |
| 1973-09-24 | vs TEX | 156 | W 10-9 | 75-81 | 5 | 3,753 | Clyde Wright | Pete Broberg | Steve Barber | Lloyd Allen | | 610 | 635 | -25 |
| 1973-09-25 | vs TEX | 157 | L 1-4 | 75-82 | 5 | 5,044 | Bill Singer | Steve Dunning | Steve Dunning | Bill Singer | Steve Foucault | 611 | 639 | -28 |
| 1973-09-26 | vs TEX | 158 | W 5-4 | 76-82 | 4 | 3,923 | Rich Hand | Sonny Siebert | Dave Sells | Jim Merritt | | 616 | 643 | -27 |
| 1973-09-27 | vs MIN | 159 | W 5-4 | 77-82 | 4 | 9,100 | Nolan Ryan | Dave Goltz | Nolan Ryan | Bill Campbell | | 621 | 647 | -26 |
| 1973-09-28 | vs MIN | 160 | L 1-7 | 77-83 | 4 | 5,430 | Rudy May | Danny Fife | Danny Fife | Rudy May | | 622 | 654 | -32 |
| 1973-09-29 | vs MIN | 161 | W 4-3 | 78-83 | 4 | 14,783 | Bill Singer | Ray Corbin | Bill Singer | Bill Campbell | | 626 | 657 | -31 |
| 1973-09-30 | vs MIN | 162 | W 3-0 | 79-83 | 4 | 7,489 | Frank Tanana | Bert Blyleven | Frank Tanana | Bert Blyleven | | 629 | 657 | -28 |