| 1973-04-06 | vs LAN | 1 | W 4-2 | 1-0 | 2 | 32,019 | Clay Kirby | Don Sutton | Clay Kirby | Don Sutton | Vicente Romo | 4 | 2 | 2 |
| 1973-04-07 | vs LAN | 2 | W 4-3 | 2-0 | 2 | 16,803 | Fred Norman | Andy Messersmith | Vicente Romo | Jim Brewer | | 8 | 5 | 3 |
| 1973-04-08 | vs LAN | 3 | L 0-4 | 2-1 | 2 | 10,695 | Steve Arlin | Tommy John | Tommy John | Steve Arlin | George Culver | 8 | 9 | -1 |
| 1973-04-09 | @ SFN | 4 | L 1-2 | 2-2 | 4 | 18,560 | Mike Caldwell | Ron Bryant | Ron Bryant | Mike Caldwell | | 9 | 11 | -2 |
| 1973-04-10 | @ SFN | 5 | L 2-11 | 2-3 | 4 | 6,098 | Mike Corkins | Juan Marichal | Juan Marichal | Mike Corkins | Jim Barr | 11 | 22 | -11 |
| 1973-04-11 | vs ATL | 6 | L 1-8 | 2-4 | 5 | 5,437 | Clay Kirby | Gary Gentry | Gary Gentry | Clay Kirby | | 12 | 30 | -18 |
| 1973-04-12 | vs ATL | 7 | L 2-3 | 2-5 | 5 | 3,225 | Fred Norman | Pat Dobson | Pat Dobson | Fred Norman | Roric Harrison | 14 | 33 | -19 |
| 1973-04-13 | vs HOU | 8 | W 5-4 | 3-5 | 5 | 5,310 | Steve Arlin | Don Wilson | Gary Ross | Don Wilson | | 19 | 37 | -18 |
| 1973-04-14 | vs HOU | 9 | L 5-8 | 3-6 | 6 | 7,514 | Mike Caldwell | Jerry Reuss | Jim York | Mike Caldwell | | 24 | 45 | -21 |
| 1973-04-15 | vs HOU | 10 | W 5-1 | 5-6 | 4 | 0 | Mike Corkins | Dave Roberts | Mike Corkins | Dave Roberts | | 29 | 46 | -17 |
| 1973-04-15 | vs HOU | 11 | W 4-0 | 5-6 | 4 | 10,993 | Bill Greif | Tom Griffin | Bill Greif | Tom Griffin | | 33 | 46 | -13 |
| 1973-04-16 | vs CIN | 12 | L 6-7 | 5-7 | 5 | 9,189 | Clay Kirby | Jack Billingham | Jack Billingham | Clay Kirby | Clay Carroll | 39 | 53 | -14 |
| 1973-04-17 | vs CIN | 13 | L 0-3 | 5-8 | 5 | 7,976 | Fred Norman | Ross Grimsley | Ross Grimsley | Fred Norman | | 39 | 56 | -17 |
| 1973-04-18 | vs CIN | 14 | W 4-2 | 6-8 | 5 | 10,587 | Steve Arlin | Roger Nelson | Steve Arlin | Roger Nelson | Bill Greif | 43 | 58 | -15 |
| 1973-04-20 | @ HOU | 15 | L 2-6 | 6-9 | 5 | 21,261 | Mike Corkins | Ken Forsch | Ken Forsch | Mike Corkins | Jim Crawford | 45 | 64 | -19 |
| 1973-04-21 | @ HOU | 16 | L 0-4 | 6-10 | 5 | 21,457 | Clay Kirby | Don Wilson | Don Wilson | Clay Kirby | | 45 | 68 | -23 |
| 1973-04-22 | @ HOU | 17 | L 3-4 | 6-11 | 5 | 11,396 | Fred Norman | Jerry Reuss | Jerry Reuss | Gary Ross | Jim York | 48 | 72 | -24 |
| 1973-04-23 | @ HOU | 18 | L 0-2 | 6-12 | 5 | 9,270 | Bill Greif | Dave Roberts | Dave Roberts | Bill Greif | Jim York | 48 | 74 | -26 |
| 1973-04-24 | @ PIT | 19 | W 7-5 | 7-12 | 5 | 10,108 | Steve Arlin | Bob Moose | Rich Troedson | Bob Moose | Vicente Romo | 55 | 79 | -24 |
| 1973-04-27 | @ CHN | 20 | L 2-10 | 7-13 | 6 | 6,532 | Clay Kirby | Milt Pappas | Milt Pappas | Clay Kirby | Bob Locker | 57 | 89 | -32 |
| 1973-04-28 | @ CHN | 21 | L 0-2 | 7-14 | 6 | 12,294 | Fred Norman | Rick Reuschel | Rick Reuschel | Fred Norman | Jack Aker | 57 | 91 | -34 |
| 1973-04-29 | @ CHN | 22 | L 4-10 | 7-15 | 6 | 12,866 | Steve Arlin | Fergie Jenkins | Fergie Jenkins | Mike Caldwell | Bob Locker | 61 | 101 | -40 |
| 1973-05-01 | vs SLN | 23 | W 10-5 | 8-15 | 5 | 3,965 | Mike Corkins | Scipio Spinks | Mike Corkins | Scipio Spinks | Vicente Romo | 71 | 106 | -35 |
| 1973-05-02 | vs SLN | 24 | L 4-5 | 8-16 | 5 | 5,690 | Clay Kirby | Bob Gibson | Bob Gibson | Clay Kirby | Diego Segui | 75 | 111 | -36 |
| 1973-05-03 | vs SLN | 25 | L 1-3 | 8-17 | 5 | 2,952 | Bill Greif | Reggie Cleveland | Reggie Cleveland | Bill Greif | | 76 | 114 | -38 |
| 1973-05-04 | vs PIT | 26 | L 6-12 | 8-18 | 5 | 9,595 | Fred Norman | Steve Blass | Steve Blass | Fred Norman | | 82 | 126 | -44 |
| 1973-05-05 | vs PIT | 27 | W 6-5 | 9-18 | 6 | 10,619 | Mike Corkins | Dock Ellis | Vicente Romo | Dock Ellis | | 88 | 131 | -43 |
| 1973-05-06 | vs PIT | 28 | W 8-0 | 10-18 | 6 | 7,176 | Mike Caldwell | Bob Moose | Mike Caldwell | Bob Moose | | 96 | 131 | -35 |
| 1973-05-07 | vs CHN | 29 | W 4-1 | 11-18 | 5 | 16,651 | Bill Greif | Rick Reuschel | Bill Greif | Rick Reuschel | | 100 | 132 | -32 |
| 1973-05-08 | vs CHN | 30 | L 2-3 | 11-19 | 6 | 4,554 | Fred Norman | Fergie Jenkins | Bob Locker | Gary Ross | Bill Bonham | 102 | 135 | -33 |
| 1973-05-09 | vs CHN | 31 | L 2-9 | 11-20 | 6 | 5,276 | Mike Corkins | Burt Hooton | Burt Hooton | Mike Corkins | | 104 | 144 | -40 |
| 1973-05-12 | @ ATL | 32 | L 2-14 | 11-21 | 6 | 5,679 | Mike Caldwell | Gary Gentry | Gary Gentry | Mike Caldwell | | 106 | 158 | -52 |
| 1973-05-13 | @ ATL | 33 | W 6-4 | 12-22 | 6 | 0 | Bill Greif | Pat Dobson | Bill Greif | Pat Dobson | | 112 | 162 | -50 |
| 1973-05-13 | @ ATL | 34 | L 2-6 | 12-22 | 6 | 7,395 | Fred Norman | Ron Reed | Ron Reed | Fred Norman | Roric Harrison | 114 | 168 | -54 |
| 1973-05-14 | vs SFN | 35 | W 7-1 | 13-22 | 6 | 4,008 | Mike Corkins | Tom Bradley | Mike Corkins | Tom Bradley | | 121 | 169 | -48 |
| 1973-05-15 | vs SFN | 36 | L 2-4 | 13-23 | 6 | 7,322 | Vicente Romo | Ron Bryant | Ron Bryant | Vicente Romo | Randy Moffitt | 123 | 173 | -50 |
| 1973-05-16 | vs SFN | 37 | W 4-1 | 14-23 | 6 | 7,989 | Mike Caldwell | Juan Marichal | Mike Caldwell | Juan Marichal | | 127 | 174 | -47 |
| 1973-05-18 | @ CIN | 38 | L 4-5 | 14-24 | 6 | 28,109 | Bill Greif | Jack Billingham | Jack Billingham | Bill Greif | | 131 | 179 | -48 |
| 1973-05-19 | @ CIN | 39 | L 4-10 | 14-25 | 6 | 18,839 | Mike Corkins | Jim McGlothlin | Jim McGlothlin | Mike Corkins | Ed Sprague | 135 | 189 | -54 |
| 1973-05-20 | @ CIN | 40 | W 2-1 | 15-26 | 6 | 0 | Fred Norman | Ross Grimsley | Fred Norman | Ross Grimsley | | 137 | 190 | -53 |
| 1973-05-20 | @ CIN | 41 | L 2-3 | 15-26 | 6 | 29,055 | Mike Caldwell | Don Gullett | Don Gullett | Mike Caldwell | Tom Hall | 139 | 193 | -54 |
| 1973-05-22 | @ LAN | 42 | L 1-5 | 15-27 | 6 | 13,562 | Bill Greif | Don Sutton | Don Sutton | Bill Greif | | 140 | 198 | -58 |
| 1973-05-23 | @ LAN | 43 | W 4-3 | 16-27 | 6 | 11,975 | Mike Corkins | Andy Messersmith | Steve Arlin | Andy Messersmith | Vicente Romo | 144 | 201 | -57 |
| 1973-05-25 | vs PHI | 44 | L 1-8 | 16-28 | 6 | 26,615 | Fred Norman | Ken Brett | Ken Brett | Fred Norman | | 145 | 209 | -64 |
| 1973-05-26 | vs PHI | 45 | L 0-4 | 16-29 | 6 | 7,260 | Mike Caldwell | Steve Carlton | Steve Carlton | Mike Caldwell | | 145 | 213 | -68 |
| 1973-05-27 | vs PHI | 46 | L 3-4 | 16-31 | 6 | 0 | Bill Greif | Wayne Twitchell | Wayne Twitchell | Bill Greif | Barry Lersch | 148 | 217 | -69 |
| 1973-05-27 | vs PHI | 47 | L 4-6 | 16-31 | 6 | 9,983 | Steve Arlin | Larry Christenson | Jim Lonborg | Steve Arlin | Mac Scarce | 152 | 223 | -71 |
| 1973-05-28 | vs MON | 48 | L 6-7 | 16-32 | 6 | 3,161 | Mike Corkins | Ernie McAnally | Mike Marshall | Gary Ross | Bill Stoneman | 158 | 230 | -72 |
| 1973-05-30 | vs MON | 49 | L 3-5 | 17-33 | 6 | 0 | Fred Norman | Bill Stoneman | Bill Stoneman | Fred Norman | Mike Marshall | 161 | 235 | -74 |
| 1973-05-30 | vs MON | 50 | W 3-2 | 17-33 | 6 | 5,566 | Mike Caldwell | Mike Torrez | Mike Caldwell | Mike Marshall | Rich Troedson | 164 | 237 | -73 |
| 1973-06-01 | vs NYN | 51 | W 4-0 | 18-33 | 6 | 6,394 | Bill Greif | Jerry Koosman | Bill Greif | Jerry Koosman | | 168 | 237 | -69 |
| 1973-06-02 | vs NYN | 52 | W 3-0 | 19-33 | 6 | 7,376 | Clay Kirby | George Stone | Clay Kirby | George Stone | | 171 | 237 | -66 |
| 1973-06-03 | vs NYN | 53 | L 2-9 | 19-34 | 6 | 9,665 | Mike Caldwell | Tom Seaver | Tom Seaver | Mike Caldwell | | 173 | 246 | -73 |
| 1973-06-05 | @ SLN | 54 | L 3-5 | 19-35 | 6 | 12,616 | Bill Greif | Alan Foster | Diego Segui | Bill Greif | | 176 | 251 | -75 |
| 1973-06-06 | @ SLN | 55 | L 3-6 | 19-36 | 6 | 15,857 | Clay Kirby | Bob Gibson | Bob Gibson | Clay Kirby | | 179 | 257 | -78 |
| 1973-06-07 | @ SLN | 56 | W 4-3 | 20-36 | 6 | 14,313 | Mike Caldwell | Reggie Cleveland | Rich Troedson | Wayne Granger | Mike Corkins | 183 | 260 | -77 |
| 1973-06-08 | @ PHI | 57 | L 1-5 | 20-37 | 6 | 18,096 | Steve Arlin | Steve Carlton | Steve Carlton | Steve Arlin | | 184 | 265 | -81 |
| 1973-06-09 | @ PHI | 58 | L 1-4 | 20-38 | 6 | 15,226 | Bill Greif | Ken Brett | Ken Brett | Bill Greif | Bill Wilson | 185 | 269 | -84 |
| 1973-06-10 | @ PHI | 59 | L 0-11 | 20-39 | 6 | 27,863 | Clay Kirby | Wayne Twitchell | Wayne Twitchell | Clay Kirby | | 185 | 280 | -95 |
| 1973-06-12 | @ MON | 60 | L 4-7 | 20-40 | 6 | 12,352 | Mike Caldwell | Mike Torrez | Mickey Scott | Mike Caldwell | Tom Walker | 189 | 287 | -98 |
| 1973-06-13 | @ MON | 61 | L 2-3 | 20-41 | 6 | 20,152 | Bill Greif | Balor Moore | Balor Moore | Bill Greif | Mike Marshall | 191 | 290 | -99 |
| 1973-06-14 | @ MON | 62 | L 3-5 | 20-42 | 6 | 11,522 | Clay Kirby | Steve Renko | Steve Renko | Gary Ross | | 194 | 295 | -101 |
| 1973-06-15 | @ NYN | 63 | L 2-5 | 20-43 | 6 | 27,524 | Steve Arlin | Jon Matlack | Jon Matlack | Steve Arlin | | 196 | 300 | -104 |
| 1973-06-16 | @ NYN | 64 | L 2-10 | 20-44 | 6 | 24,452 | Mike Caldwell | Jerry Koosman | Jerry Koosman | Mike Caldwell | | 198 | 310 | -112 |
| 1973-06-17 | @ NYN | 65 | L 1-3 | 20-45 | 6 | 32,641 | Bill Greif | George Stone | George Stone | Bill Greif | Tug McGraw | 199 | 313 | -114 |
| 1973-06-19 | vs HOU | 66 | L 3-7 | 20-46 | 6 | 5,338 | Clay Kirby | Jerry Reuss | Jerry Reuss | Clay Kirby | Jim Crawford | 202 | 320 | -118 |
| 1973-06-20 | vs HOU | 67 | W 6-2 | 21-46 | 6 | 8,076 | Steve Arlin | Dave Roberts | Steve Arlin | Dave Roberts | | 208 | 322 | -114 |
| 1973-06-21 | vs HOU | 68 | L 2-12 | 21-47 | 6 | 2,474 | Bill Greif | Ken Forsch | Ken Forsch | Bill Greif | | 210 | 334 | -124 |
| 1973-06-22 | vs ATL | 69 | L 3-7 | 21-48 | 6 | 6,039 | Randy Jones | Phil Niekro | Phil Niekro | Randy Jones | Joe Hoerner | 213 | 341 | -128 |
| 1973-06-23 | vs ATL | 70 | W 2-0 | 23-48 | 6 | 0 | Clay Kirby | Ron Reed | Clay Kirby | Ron Reed | | 215 | 341 | -126 |
| 1973-06-23 | vs ATL | 71 | W 9-3 | 23-48 | 6 | 17,215 | Rich Troedson | Jimmy Freeman | Rich Troedson | Jimmy Freeman | Vicente Romo | 224 | 344 | -120 |
| 1973-06-24 | vs ATL | 72 | L 1-6 | 23-49 | 6 | 4,490 | Steve Arlin | Carl Morton | Phil Niekro | Steve Arlin | | 225 | 350 | -125 |
| 1973-06-25 | vs LAN | 73 | L 2-3 | 23-50 | 6 | 6,916 | Bill Greif | Claude Osteen | Claude Osteen | Bill Greif | Jim Brewer | 227 | 353 | -126 |
| 1973-06-26 | vs LAN | 74 | L 0-7 | 23-51 | 6 | 10,408 | Randy Jones | Don Sutton | Don Sutton | Randy Jones | | 227 | 360 | -133 |
| 1973-06-28 | @ CIN | 75 | W 6-1 | 24-51 | 6 | 15,756 | Clay Kirby | Don Gullett | Clay Kirby | Don Gullett | | 233 | 361 | -128 |
| 1973-06-29 | @ CIN | 76 | L 0-4 | 24-52 | 6 | 15,268 | Rich Troedson | Jack Billingham | Jack Billingham | Mike Corkins | | 233 | 365 | -132 |
| 1973-06-30 | @ HOU | 77 | W 3-0 | 25-52 | 6 | 19,340 | Steve Arlin | Ken Forsch | Steve Arlin | Ken Forsch | | 236 | 365 | -129 |
| 1973-07-01 | @ HOU | 78 | L 4-6 | 25-53 | 6 | 17,524 | Bill Greif | Don Wilson | Don Wilson | Bill Greif | | 240 | 371 | -131 |
| 1973-07-02 | @ HOU | 79 | W 8-5 | 26-53 | 6 | 16,929 | Clay Kirby | Jerry Reuss | Clay Kirby | Jim Crawford | Vicente Romo | 248 | 376 | -128 |
| 1973-07-03 | @ LAN | 80 | W 4-1 | 27-53 | 6 | 18,551 | Randy Jones | Tommy John | Randy Jones | Tommy John | | 252 | 377 | -125 |
| 1973-07-04 | @ LAN | 81 | W 4-2 | 28-53 | 6 | 46,681 | Rich Troedson | Al Downing | Rich Troedson | Al Downing | Mike Caldwell | 256 | 379 | -123 |
| 1973-07-05 | @ LAN | 82 | W 3-0 | 29-53 | 6 | 18,397 | Steve Arlin | Claude Osteen | Steve Arlin | Claude Osteen | | 259 | 379 | -120 |
| 1973-07-06 | vs CHN | 83 | L 5-8 | 29-54 | 6 | 7,768 | Clay Kirby | Fergie Jenkins | Fergie Jenkins | Clay Kirby | | 264 | 387 | -123 |
| 1973-07-07 | vs CHN | 84 | W 4-3 | 30-54 | 6 | 17,695 | Bill Greif | Milt Pappas | Bill Greif | Milt Pappas | Mike Caldwell | 268 | 390 | -122 |
| 1973-07-08 | vs CHN | 85 | W 4-2 | 31-54 | 6 | 11,786 | Randy Jones | Burt Hooton | Randy Jones | Burt Hooton | | 272 | 392 | -120 |
| 1973-07-10 | vs PIT | 86 | L 3-4 | 31-55 | 6 | 12,233 | Rich Troedson | Bob Moose | Bob Johnson | Rich Troedson | John Lamb | 275 | 396 | -121 |
| 1973-07-11 | vs PIT | 87 | L 2-10 | 31-56 | 6 | 4,763 | Steve Arlin | Nelson Briles | Nelson Briles | Steve Arlin | | 277 | 406 | -129 |
| 1973-07-12 | vs PIT | 88 | L 0-4 | 31-57 | 6 | 2,865 | Clay Kirby | Luke Walker | Luke Walker | Clay Kirby | | 277 | 410 | -133 |
| 1973-07-13 | vs SLN | 89 | L 3-5 | 31-58 | 6 | 25,483 | Bill Greif | Rick Wise | Rick Wise | Frank Snook | Diego Segui | 280 | 415 | -135 |
| 1973-07-14 | vs SLN | 90 | L 3-5 | 31-59 | 6 | 5,358 | Randy Jones | Alan Foster | Alan Foster | Randy Jones | | 283 | 420 | -137 |
| 1973-07-15 | vs SLN | 91 | L 4-5 | 31-60 | 6 | 4,125 | Rich Troedson | Tom Murphy | Al Hrabosky | Mike Corkins | | 287 | 425 | -138 |
| 1973-07-17 | @ CHN | 92 | W 1-0 | 32-60 | 6 | 22,194 | Steve Arlin | Milt Pappas | Steve Arlin | Milt Pappas | | 288 | 425 | -137 |
| 1973-07-18 | @ CHN | 93 | W 8-5 | 33-60 | 6 | 18,354 | Clay Kirby | Fergie Jenkins | Clay Kirby | Fergie Jenkins | Mike Caldwell | 296 | 430 | -134 |
| 1973-07-19 | @ CHN | 94 | L 5-12 | 33-61 | 6 | 15,421 | Bill Greif | Burt Hooton | Burt Hooton | Mike Corkins | Bill Bonham | 301 | 442 | -141 |
| 1973-07-20 | @ PIT | 95 | L 4-5 | 33-63 | 6 | 0 | Randy Jones | John Morlan | Dave Giusti | Mike Caldwell | | 305 | 447 | -142 |
| 1973-07-20 | @ PIT | 96 | L 0-7 | 33-63 | 6 | 25,832 | Rich Troedson | Jim Rooker | Jim Rooker | Rich Troedson | | 305 | 454 | -149 |
| 1973-07-22 | @ PIT | 97 | L 1-3 | 33-65 | 6 | 0 | Steve Arlin | Nelson Briles | Nelson Briles | Steve Arlin | Dave Giusti | 306 | 457 | -151 |
| 1973-07-22 | @ PIT | 98 | L 7-13 | 33-65 | 6 | 22,425 | Clay Kirby | Luke Walker | Luke Walker | Clay Kirby | John Lamb | 313 | 470 | -157 |
| 1973-07-26 | @ SFN | 99 | L 2-10 | 33-67 | 6 | 0 | Steve Arlin | Ron Bryant | Ron Bryant | Steve Arlin | | 315 | 480 | -165 |
| 1973-07-26 | @ SFN | 100 | L 5-6 | 33-67 | 6 | 8,338 | Clay Kirby | Jim Willoughby | Elias Sosa | Mike Caldwell | | 320 | 486 | -166 |
| 1973-07-27 | @ SFN | 101 | W 6-2 | 34-67 | 6 | 5,470 | Bill Greif | Juan Marichal | Bill Greif | Juan Marichal | | 326 | 488 | -162 |
| 1973-07-28 | vs CIN | 102 | L 1-2 | 34-68 | 6 | 8,860 | Randy Jones | Tom Hall | Don Gullett | Vicente Romo | | 327 | 490 | -163 |
| 1973-07-29 | vs CIN | 103 | W 7-1 | 35-69 | 6 | 0 | Rich Troedson | Gary Nolan | Rich Troedson | Gary Nolan | | 334 | 491 | -157 |
| 1973-07-29 | vs CIN | 104 | L 2-4 | 35-69 | 6 | 10,499 | Mike Caldwell | Roger Nelson | Roger Nelson | Mike Caldwell | Clay Carroll | 336 | 495 | -159 |
| 1973-07-31 | vs SFN | 105 | L 1-5 | 35-70 | 6 | 8,538 | Steve Arlin | Juan Marichal | Juan Marichal | Steve Arlin | | 337 | 500 | -163 |
| 1973-08-01 | vs SFN | 106 | W 6-5 | 36-70 | 6 | 5,380 | Clay Kirby | Jim Barr | Clay Kirby | Jim Barr | | 343 | 505 | -162 |
| 1973-08-03 | @ ATL | 107 | L 4-5 | 36-71 | 6 | 6,920 | Bill Greif | Ron Schueler | Max Leon | Mike Caldwell | | 347 | 510 | -163 |
| 1973-08-04 | @ ATL | 108 | W 4-3 | 37-72 | 6 | 0 | Randy Jones | Gary Neibauer | Gary Ross | Adrian Devine | Mike Caldwell | 351 | 513 | -162 |
| 1973-08-04 | @ ATL | 109 | L 3-14 | 37-72 | 6 | 14,906 | Rich Troedson | Carl Morton | Carl Morton | Rich Troedson | | 354 | 527 | -173 |
| 1973-08-05 | @ ATL | 110 | L 0-9 | 37-73 | 6 | 8,748 | Steve Arlin | Phil Niekro | Phil Niekro | Steve Arlin | | 354 | 536 | -182 |
| 1973-08-06 | vs LAN | 111 | L 0-2 | 37-74 | 6 | 8,050 | Clay Kirby | Al Downing | Al Downing | Clay Kirby | | 354 | 538 | -184 |
| 1973-08-07 | vs LAN | 112 | L 1-6 | 37-75 | 6 | 12,186 | Rich Troedson | Don Sutton | Don Sutton | Rich Troedson | Jim Brewer | 355 | 544 | -189 |
| 1973-08-08 | vs PHI | 113 | W 3-0 | 38-75 | 6 | 2,696 | Bill Greif | Steve Carlton | Bill Greif | Steve Carlton | | 358 | 544 | -186 |
| 1973-08-09 | vs PHI | 114 | W 10-9 | 39-75 | 6 | 4,791 | Randy Jones | Jim Lonborg | Mike Corkins | Bucky Brandon | | 368 | 553 | -185 |
| 1973-08-10 | vs MON | 115 | W 4-3 | 40-75 | 6 | 4,842 | Steve Arlin | Balor Moore | Steve Arlin | Balor Moore | Mike Caldwell | 372 | 556 | -184 |
| 1973-08-12 | vs MON | 116 | L 0-2 | 41-76 | 6 | 0 | Clay Kirby | Steve Rogers | Steve Rogers | Clay Kirby | Mike Marshall | 372 | 558 | -186 |
| 1973-08-12 | vs MON | 117 | W 4-3 | 41-76 | 6 | 5,617 | Rich Troedson | Steve Renko | Mike Caldwell | Mike Marshall | | 376 | 561 | -185 |
| 1973-08-13 | vs NYN | 118 | W 3-2 | 42-76 | 6 | 2,440 | Bill Greif | Jon Matlack | Mike Caldwell | Jon Matlack | | 379 | 563 | -184 |
| 1973-08-14 | vs NYN | 119 | W 9-0 | 43-76 | 6 | 3,969 | Randy Jones | Jerry Koosman | Randy Jones | Jerry Koosman | | 388 | 563 | -175 |
| 1973-08-15 | vs NYN | 120 | L 0-7 | 43-77 | 6 | 6,531 | Steve Arlin | Tom Seaver | Tom Seaver | Steve Arlin | | 388 | 570 | -182 |
| 1973-08-17 | @ SLN | 121 | W 4-2 | 44-77 | 6 | 20,309 | Clay Kirby | Reggie Cleveland | Mike Corkins | Diego Segui | Vicente Romo | 392 | 572 | -180 |
| 1973-08-18 | @ SLN | 122 | W 4-3 | 45-77 | 6 | 28,786 | Rich Troedson | Mike Nagy | Steve Arlin | Orlando Pena | Mike Caldwell | 396 | 575 | -179 |
| 1973-08-19 | @ SLN | 123 | L 0-1 | 45-78 | 6 | 22,432 | Bill Greif | Alan Foster | Alan Foster | Bill Greif | | 396 | 576 | -180 |
| 1973-08-21 | @ PHI | 124 | L 8-9 | 45-79 | 6 | 13,108 | Randy Jones | Ken Brett | George Culver | Mike Caldwell | | 404 | 585 | -181 |
| 1973-08-22 | @ PHI | 125 | W 8-3 | 46-79 | 6 | 16,131 | Steve Arlin | Steve Carlton | Steve Arlin | Steve Carlton | | 412 | 588 | -176 |
| 1973-08-23 | @ PHI | 126 | L 3-6 | 46-80 | 6 | 10,601 | Clay Kirby | Jim Lonborg | Jim Lonborg | Clay Kirby | | 415 | 594 | -179 |
| 1973-08-24 | @ MON | 127 | W 5-3 | 47-80 | 6 | 14,161 | Rich Troedson | Balor Moore | Rich Troedson | Balor Moore | Mike Caldwell | 420 | 597 | -177 |
| 1973-08-25 | @ MON | 128 | L 3-13 | 47-81 | 6 | 16,183 | Bill Greif | Mike Torrez | Mike Torrez | Bill Greif | | 423 | 610 | -187 |
| 1973-08-26 | @ MON | 129 | W 4-2 | 48-81 | 6 | 14,129 | Randy Jones | Steve Renko | Randy Jones | Steve Renko | | 427 | 612 | -185 |
| 1973-08-27 | @ NYN | 130 | L 5-6 | 48-82 | 6 | 14,790 | Steve Arlin | George Stone | George Stone | Steve Arlin | Tug McGraw | 432 | 618 | -186 |
| 1973-08-28 | @ NYN | 131 | L 6-8 | 48-83 | 6 | 16,801 | Clay Kirby | Jon Matlack | Jon Matlack | Clay Kirby | Tug McGraw | 438 | 626 | -188 |
| 1973-08-29 | @ NYN | 132 | L 0-3 | 48-84 | 6 | 18,436 | Rich Troedson | Jerry Koosman | Jerry Koosman | Rich Troedson | Buzz Capra | 438 | 629 | -191 |
| 1973-08-31 | vs CIN | 133 | L 4-10 | 48-85 | 6 | 9,518 | Bill Greif | Don Gullett | Don Gullett | Bill Greif | Clay Carroll | 442 | 639 | -197 |
| 1973-09-01 | vs CIN | 134 | L 2-3 | 48-86 | 6 | 6,948 | Randy Jones | Fred Norman | Clay Carroll | Randy Jones | Tom Hall | 444 | 642 | -198 |
| 1973-09-02 | vs CIN | 135 | L 1-6 | 48-87 | 6 | 4,894 | Steve Arlin | Ross Grimsley | Ross Grimsley | Steve Arlin | | 445 | 648 | -203 |
| 1973-09-03 | vs ATL | 136 | L 3-7 | 48-88 | 6 | 8,333 | Clay Kirby | Max Leon | Max Leon | Clay Kirby | | 448 | 655 | -207 |
| 1973-09-04 | vs ATL | 137 | L 0-3 | 48-89 | 6 | 7,247 | Rich Troedson | Roric Harrison | Roric Harrison | Rich Troedson | Joe Niekro | 448 | 658 | -210 |
| 1973-09-05 | vs ATL | 138 | W 4-3 | 49-89 | 6 | 7,229 | Bill Greif | Phil Niekro | Bill Greif | Joe Niekro | | 452 | 661 | -209 |
| 1973-09-06 | @ LAN | 139 | W 3-2 | 50-89 | 6 | 18,235 | Randy Jones | Don Sutton | Randy Jones | Don Sutton | Mike Corkins | 455 | 663 | -208 |
| 1973-09-07 | @ LAN | 140 | W 4-3 | 51-89 | 6 | 15,931 | Steve Arlin | Claude Osteen | Steve Arlin | Claude Osteen | Mike Caldwell | 459 | 666 | -207 |
| 1973-09-08 | @ LAN | 141 | W 9-6 | 52-89 | 6 | 29,860 | Clay Kirby | Tommy John | Gary Ross | Pete Richert | Frank Snook | 468 | 672 | -204 |
| 1973-09-09 | @ LAN | 142 | L 3-5 | 52-90 | 6 | 20,565 | Rich Troedson | Andy Messersmith | Andy Messersmith | Rich Troedson | | 471 | 677 | -206 |
| 1973-09-10 | vs HOU | 143 | W 5-3 | 53-90 | 6 | 2,294 | Bill Greif | Tom Griffin | Bill Greif | Tom Griffin | | 476 | 680 | -204 |
| 1973-09-11 | vs HOU | 144 | L 2-4 | 53-91 | 6 | 1,413 | Randy Jones | Doug Konieczny | Don Wilson | Vicente Romo | | 478 | 684 | -206 |
| 1973-09-13 | vs SFN | 145 | L 6-8 | 53-92 | 6 | 2,586 | Steve Arlin | Jim Barr | Elias Sosa | Frank Snook | Don McMahon | 484 | 692 | -208 |
| 1973-09-14 | vs SFN | 146 | W 4-3 | 54-92 | 6 | 5,341 | Clay Kirby | Juan Marichal | Clay Kirby | Juan Marichal | Mike Caldwell | 488 | 695 | -207 |
| 1973-09-15 | vs SFN | 147 | L 2-5 | 54-93 | 6 | 5,376 | Rich Troedson | Tom Bradley | Tom Bradley | Rich Troedson | Don McMahon | 490 | 700 | -210 |
| 1973-09-16 | vs SFN | 148 | L 4-9 | 54-94 | 6 | 7,815 | Bill Greif | Ron Bryant | Ron Bryant | Bill Greif | Randy Moffitt | 494 | 709 | -215 |
| 1973-09-17 | @ ATL | 149 | L 0-7 | 54-94 | 6 | 1,362 | Randy Jones | Carl Morton | Carl Morton | Randy Jones | | 494 | 716 | -222 |
| 1973-09-18 | @ ATL | 150 | W 9-4 | 54-94 | 6 | 4,236 | Steve Arlin | Roric Harrison | Steve Arlin | Roric Harrison | | 503 | 720 | -217 |
| 1973-09-19 | @ HOU | 151 | L 5-8 | 55-95 | 6 | 0 | Clay Kirby | Tom Griffin | Tom Griffin | Clay Kirby | | 508 | 728 | -220 |
| 1973-09-19 | @ HOU | 152 | W 6-3 | 55-95 | 6 | 5,488 | Rich Troedson | Doug Konieczny | Rich Troedson | Doug Konieczny | | 514 | 731 | -217 |
| 1973-09-21 | @ SFN | 153 | W 3-1 | 56-96 | 6 | 0 | Bill Greif | Jim Barr | Bill Greif | Jim Barr | Mike Caldwell | 517 | 732 | -215 |
| 1973-09-21 | @ SFN | 154 | L 2-7 | 56-96 | 6 | 2,992 | Randy Jones | John D'Acquisto | John D'Acquisto | Randy Jones | | 519 | 739 | -220 |
| 1973-09-22 | @ SFN | 155 | L 2-5 | 56-97 | 6 | 3,148 | Steve Arlin | Juan Marichal | Juan Marichal | Steve Arlin | | 521 | 744 | -223 |
| 1973-09-23 | @ SFN | 156 | W 11-9 | 57-97 | 6 | 18,930 | Clay Kirby | Tom Bradley | Gary Ross | Elias Sosa | | 532 | 753 | -221 |
| 1973-09-24 | @ CIN | 157 | L 1-2 | 57-98 | 6 | 16,395 | Rich Troedson | Dick Baney | Dick Baney | Rich Troedson | Pedro Borbon | 533 | 755 | -222 |
| 1973-09-25 | @ CIN | 158 | L 2-3 | 57-99 | 6 | 12,724 | Bill Greif | Jack Billingham | Jack Billingham | Bill Greif | | 535 | 758 | -223 |
| 1973-09-26 | @ CIN | 159 | W 5-1 | 58-99 | 6 | 12,239 | Randy Jones | Ross Grimsley | Randy Jones | Ross Grimsley | | 540 | 759 | -219 |
| 1973-09-28 | vs LAN | 160 | L 2-5 | 58-100 | 6 | 9,169 | Mike Corkins | Tommy John | Tommy John | Mike Corkins | Charlie Hough | 542 | 764 | -222 |
| 1973-09-29 | vs LAN | 161 | L 2-3 | 58-101 | 6 | 14,846 | Clay Kirby | Geoff Zahn | Geoff Zahn | Clay Kirby | Greg Shanahan | 544 | 767 | -223 |
| 1973-10-01 | @ PIT | 162 | W 4-3 | 59-101 | 6 | 2,572 | Randy Jones | Bruce Kison | Randy Jones | Bob Moose | Mike Corkins | 548 | 770 | -222 |