| 1973-04-06 | vs MIN | 1 | L 3-8 | 0-1 | 5 | 38,207 | Catfish Hunter | Bert Blyleven | Bert Blyleven | Catfish Hunter | | 3 | 8 | -5 |
| 1973-04-07 | vs MIN | 2 | L 3-5 | 0-2 | 5 | 7,246 | Blue Moon Odom | Bill Hands | Bill Hands | Blue Moon Odom | Ken Sanders | 6 | 13 | -7 |
| 1973-04-08 | vs MIN | 3 | L 2-4 | 0-3 | 5 | 8,919 | Ken Holtzman | Jim Kaat | Jim Kaat | Ken Holtzman | Ray Corbin | 8 | 17 | -9 |
| 1973-04-11 | @ CHA | 4 | W 12-2 | 1-3 | 5 | 22,091 | Vida Blue | Wilbur Wood | Vida Blue | Wilbur Wood | | 20 | 19 | 1 |
| 1973-04-12 | @ CHA | 5 | L 3-6 | 1-4 | 6 | 3,837 | Catfish Hunter | Stan Bahnsen | Terry Forster | Darold Knowles | | 23 | 25 | -2 |
| 1973-04-13 | @ MIN | 6 | L 4-8 | 1-5 | 6 | 13,040 | Blue Moon Odom | Jim Kaat | Jim Kaat | Blue Moon Odom | Ray Corbin | 27 | 33 | -6 |
| 1973-04-14 | @ MIN | 7 | W 2-1 | 2-5 | 6 | 10,711 | Ken Holtzman | Bert Blyleven | Ken Holtzman | Bert Blyleven | | 29 | 34 | -5 |
| 1973-04-17 | @ KCA | 8 | L 4-5 | 2-6 | 6 | 22,119 | Vida Blue | Wayne Simpson | Gene Garber | Horacio Pina | | 33 | 39 | -6 |
| 1973-04-18 | @ KCA | 9 | W 7-6 | 3-6 | 5 | 17,717 | Catfish Hunter | Dick Drago | Horacio Pina | Bruce Dal Canton | | 40 | 45 | -5 |
| 1973-04-19 | @ KCA | 10 | L 8-16 | 3-7 | 5 | 17,441 | Blue Moon Odom | Paul Splittorff | Paul Splittorff | Blue Moon Odom | Gene Garber | 48 | 61 | -13 |
| 1973-04-20 | vs CAL | 11 | W 4-3 | 4-7 | 5 | 6,142 | Ken Holtzman | Clyde Wright | Ken Holtzman | Clyde Wright | | 52 | 64 | -12 |
| 1973-04-21 | vs CAL | 12 | L 2-4 | 4-8 | 5 | 7,161 | Vida Blue | Bill Singer | Bill Singer | Vida Blue | Lloyd Allen | 54 | 68 | -14 |
| 1973-04-22 | vs CAL | 13 | W 3-2 | 5-8 | 5 | 7,442 | Catfish Hunter | Nolan Ryan | Horacio Pina | Ron Perranoski | | 57 | 70 | -13 |
| 1973-04-23 | vs CAL | 14 | L 0-4 | 5-9 | 5 | 14,752 | Blue Moon Odom | Rudy May | Rudy May | Blue Moon Odom | | 57 | 74 | -17 |
| 1973-04-24 | vs CLE | 15 | W 4-0 | 6-9 | 5 | 4,119 | Ken Holtzman | Gaylord Perry | Ken Holtzman | Gaylord Perry | Horacio Pina | 61 | 74 | -13 |
| 1973-04-25 | vs CLE | 16 | L 0-1 | 6-10 | 5 | 3,274 | Rollie Fingers | Dick Tidrow | Dick Tidrow | Rollie Fingers | | 61 | 75 | -14 |
| 1973-04-26 | vs CLE | 17 | W 3-2 | 7-10 | 5 | 3,146 | Catfish Hunter | Brent Strom | Darold Knowles | Jerry Johnson | | 64 | 77 | -13 |
| 1973-04-27 | vs BAL | 18 | W 4-3 | 8-10 | 5 | 5,971 | Blue Moon Odom | Mike Cuellar | Horacio Pina | Eddie Watt | | 68 | 80 | -12 |
| 1973-04-28 | vs BAL | 19 | L 1-2 | 8-11 | 5 | 6,380 | Ken Holtzman | Jim Palmer | Jim Palmer | Ken Holtzman | | 69 | 82 | -13 |
| 1973-04-29 | vs BAL | 20 | W 4-3 | 9-11 | 5 | 18,306 | Catfish Hunter | Dave McNally | Catfish Hunter | Dave McNally | Rollie Fingers | 73 | 85 | -12 |
| 1973-05-01 | @ MIL | 21 | L 3-4 | 9-12 | 5 | 8,838 | Blue Moon Odom | Bill Parsons | Jim Colborn | Blue Moon Odom | | 76 | 89 | -13 |
| 1973-05-02 | @ MIL | 22 | W 7-3 | 10-12 | 5 | 5,557 | Ken Holtzman | Jerry Bell | Ken Holtzman | Frank Linzy | | 83 | 92 | -9 |
| 1973-05-04 | @ CLE | 23 | W 11-4 | 11-12 | 5 | 11,624 | Catfish Hunter | Gaylord Perry | Catfish Hunter | Gaylord Perry | | 94 | 96 | -2 |
| 1973-05-05 | @ CLE | 24 | L 5-6 | 11-13 | 5 | 4,918 | Blue Moon Odom | Milt Wilcox | Jerry Johnson | Darold Knowles | Ed Farmer | 99 | 102 | -3 |
| 1973-05-06 | @ CLE | 25 | W 12-0 | 13-13 | 5 | 0 | Ken Holtzman | Dick Tidrow | Ken Holtzman | Dick Tidrow | | 111 | 102 | 9 |
| 1973-05-06 | @ CLE | 26 | W 7-3 | 13-13 | 5 | 18,062 | Vida Blue | Brent Strom | Vida Blue | Brent Strom | | 118 | 105 | 13 |
| 1973-05-07 | @ BAL | 27 | L 2-8 | 13-14 | 5 | 6,076 | Rollie Fingers | Doyle Alexander | Doyle Alexander | Rollie Fingers | | 120 | 113 | 7 |
| 1973-05-09 | @ BAL | 28 | W 4-3 | 14-14 | 4 | 7,618 | Catfish Hunter | Dave McNally | Catfish Hunter | Dave McNally | Darold Knowles | 124 | 116 | 8 |
| 1973-05-10 | @ TEX | 29 | W 17-2 | 15-14 | 4 | 6,024 | Ken Holtzman | Mike Paul | Ken Holtzman | Mike Paul | Horacio Pina | 141 | 118 | 23 |
| 1973-05-11 | @ TEX | 30 | W 4-3 | 16-14 | 3 | 18,529 | Vida Blue | Rich Hand | Vida Blue | Rich Hand | Rollie Fingers | 145 | 121 | 24 |
| 1973-05-12 | @ TEX | 31 | W 4-2 | 17-14 | 3 | 17,075 | Blue Moon Odom | Pete Broberg | Blue Moon Odom | Pete Broberg | Paul Lindblad | 149 | 123 | 26 |
| 1973-05-13 | @ TEX | 32 | L 2-7 | 17-15 | 4 | 7,194 | Catfish Hunter | Sonny Siebert | Sonny Siebert | Catfish Hunter | Bill Gogolewski | 151 | 130 | 21 |
| 1973-05-14 | vs CHA | 33 | W 5-1 | 18-15 | 4 | 29,761 | Ken Holtzman | Wilbur Wood | Ken Holtzman | Wilbur Wood | | 156 | 131 | 25 |
| 1973-05-15 | vs CHA | 34 | L 5-6 | 18-16 | 4 | 5,755 | Vida Blue | Stan Bahnsen | Cy Acosta | Rollie Fingers | Steve Stone | 161 | 137 | 24 |
| 1973-05-16 | @ CAL | 35 | L 2-7 | 18-17 | 4 | 11,087 | Blue Moon Odom | Clyde Wright | Clyde Wright | Blue Moon Odom | | 163 | 144 | 19 |
| 1973-05-17 | @ CAL | 36 | W 4-0 | 19-17 | 4 | 11,481 | Catfish Hunter | Rudy May | Catfish Hunter | Rudy May | | 167 | 144 | 23 |
| 1973-05-18 | vs KCA | 37 | W 5-4 | 20-17 | 4 | 7,535 | Ken Holtzman | Steve Busby | Ken Holtzman | Steve Busby | | 172 | 148 | 24 |
| 1973-05-19 | vs KCA | 38 | L 2-5 | 20-18 | 4 | 27,912 | Vida Blue | Dick Drago | Dick Drago | Vida Blue | Doug Bird | 174 | 153 | 21 |
| 1973-05-20 | vs KCA | 39 | L 2-8 | 20-19 | 5 | 8,249 | Blue Moon Odom | Paul Splittorff | Paul Splittorff | Blue Moon Odom | | 176 | 161 | 15 |
| 1973-05-21 | vs KCA | 40 | W 5-0 | 21-19 | 4 | 15,675 | Catfish Hunter | Bruce Dal Canton | Catfish Hunter | Bruce Dal Canton | | 181 | 161 | 20 |
| 1973-05-22 | vs TEX | 41 | W 4-1 | 22-19 | 4 | 3,196 | Ken Holtzman | Sonny Siebert | Ken Holtzman | Sonny Siebert | | 185 | 162 | 23 |
| 1973-05-23 | vs TEX | 42 | W 8-6 | 23-19 | 4 | 3,471 | Vida Blue | Pete Broberg | Horacio Pina | Bill Gogolewski | Rollie Fingers | 193 | 168 | 25 |
| 1973-05-25 | @ DET | 43 | L 0-1 | 23-20 | 5 | 24,011 | Catfish Hunter | Jim Perry | John Hiller | Rollie Fingers | | 193 | 169 | 24 |
| 1973-05-26 | @ DET | 44 | L 5-8 | 23-21 | 5 | 21,179 | Ken Holtzman | Woodie Fryman | Chuck Seelbach | Horacio Pina | John Hiller | 198 | 177 | 21 |
| 1973-05-28 | @ DET | 45 | L 3-4 | 23-22 | 5 | 21,354 | Blue Moon Odom | Joe Coleman | Joe Coleman | Blue Moon Odom | John Hiller | 201 | 181 | 20 |
| 1973-05-29 | @ NYA | 46 | L 1-7 | 23-23 | 5 | 12,941 | Catfish Hunter | Fritz Peterson | Fritz Peterson | Catfish Hunter | | 202 | 188 | 14 |
| 1973-05-30 | @ NYA | 47 | L 3-4 | 23-24 | 5 | 15,719 | Vida Blue | Doc Medich | Sparky Lyle | Darold Knowles | | 205 | 192 | 13 |
| 1973-05-31 | @ NYA | 48 | W 6-0 | 24-24 | 5 | 14,237 | Ken Holtzman | Mel Stottlemyre | Ken Holtzman | Mel Stottlemyre | Rollie Fingers | 211 | 192 | 19 |
| 1973-06-01 | @ BOS | 49 | L 2-6 | 24-25 | 5 | 28,053 | Dave Hamilton | Marty Pattin | Marty Pattin | Dave Hamilton | | 213 | 198 | 15 |
| 1973-06-02 | @ BOS | 50 | W 3-1 | 25-25 | 5 | 27,692 | Catfish Hunter | Bill Lee | Catfish Hunter | Bill Lee | | 216 | 199 | 17 |
| 1973-06-03 | @ BOS | 51 | W 12-1 | 26-25 | 5 | 31,497 | Vida Blue | Luis Tiant | Vida Blue | Luis Tiant | Horacio Pina | 228 | 200 | 28 |
| 1973-06-04 | vs MIL | 52 | L 0-2 | 26-26 | 5 | 21,573 | Ken Holtzman | Jim Colborn | Jim Colborn | Ken Holtzman | | 228 | 202 | 26 |
| 1973-06-05 | vs MIL | 53 | L 4-5 | 26-27 | 5 | 3,623 | Dave Hamilton | Chris Short | Rob Gardner | Rollie Fingers | Frank Linzy | 232 | 207 | 25 |
| 1973-06-06 | vs MIL | 54 | W 11-1 | 27-27 | 5 | 3,788 | Catfish Hunter | Jim Slaton | Catfish Hunter | Jim Slaton | Darold Knowles | 243 | 208 | 35 |
| 1973-06-08 | vs DET | 55 | L 1-4 | 27-28 | 5 | 13,135 | Vida Blue | Mickey Lolich | Mickey Lolich | Vida Blue | | 244 | 212 | 32 |
| 1973-06-09 | vs DET | 56 | W 4-0 | 28-28 | 5 | 18,779 | Ken Holtzman | Jim Perry | Ken Holtzman | Jim Perry | | 248 | 212 | 36 |
| 1973-06-10 | vs DET | 57 | W 5-0 | 29-28 | 5 | 11,782 | Catfish Hunter | Joe Coleman | Catfish Hunter | Joe Coleman | | 253 | 212 | 41 |
| 1973-06-12 | vs NYA | 58 | W 4-2 | 30-28 | 3 | 8,748 | Vida Blue | Steve Kline | Vida Blue | Steve Kline | Darold Knowles | 257 | 214 | 43 |
| 1973-06-13 | vs NYA | 59 | L 3-8 | 30-29 | 5 | 7,634 | Ken Holtzman | Fritz Peterson | Fritz Peterson | Ken Holtzman | Sparky Lyle | 260 | 222 | 38 |
| 1973-06-14 | vs NYA | 60 | W 3-0 | 31-29 | 4 | 6,925 | Dave Hamilton | Doc Medich | Dave Hamilton | Doc Medich | Rollie Fingers | 263 | 222 | 41 |
| 1973-06-15 | vs BOS | 61 | W 8-3 | 32-29 | 3 | 8,196 | Catfish Hunter | Marty Pattin | Catfish Hunter | Marty Pattin | | 271 | 225 | 46 |
| 1973-06-16 | vs BOS | 62 | W 4-3 | 33-29 | 3 | 8,935 | Vida Blue | Bill Lee | Darold Knowles | Bobby Bolin | | 275 | 228 | 47 |
| 1973-06-17 | vs BOS | 63 | L 2-4 | 33-30 | 4 | 15,172 | Ken Holtzman | Luis Tiant | Luis Tiant | Ken Holtzman | | 277 | 232 | 45 |
| 1973-06-18 | @ KCA | 64 | W 9-5 | 34-30 | 4 | 22,247 | Dave Hamilton | Mark Littell | Dave Hamilton | Mark Littell | Rollie Fingers | 286 | 237 | 49 |
| 1973-06-19 | @ KCA | 65 | W 11-6 | 35-30 | 3 | 23,934 | Catfish Hunter | Paul Splittorff | Horacio Pina | Gene Garber | | 297 | 243 | 54 |
| 1973-06-20 | @ KCA | 66 | L 4-5 | 35-31 | 4 | 20,426 | Vida Blue | Steve Busby | Gene Garber | Paul Lindblad | | 301 | 248 | 53 |
| 1973-06-21 | @ CHA | 67 | L 0-2 | 35-32 | 4 | 22,269 | Ken Holtzman | Stan Bahnsen | Stan Bahnsen | Ken Holtzman | | 301 | 250 | 51 |
| 1973-06-22 | @ CHA | 68 | W 7-1 | 36-32 | 3 | 39,605 | Dave Hamilton | Wilbur Wood | Dave Hamilton | Wilbur Wood | | 308 | 251 | 57 |
| 1973-06-23 | @ CHA | 69 | W 14-3 | 37-32 | 2 | 15,984 | Catfish Hunter | Eddie Fisher | Catfish Hunter | Eddie Fisher | | 322 | 254 | 68 |
| 1973-06-24 | @ CHA | 70 | W 7-0 | 38-33 | 3 | 0 | Vida Blue | Steve Stone | Vida Blue | Steve Stone | | 329 | 254 | 75 |
| 1973-06-24 | @ CHA | 71 | L 1-11 | 38-33 | 3 | 34,841 | Blue Moon Odom | Bart Johnson | Bart Johnson | Blue Moon Odom | Cy Acosta | 330 | 265 | 65 |
| 1973-06-25 | @ TEX | 72 | L 2-4 | 38-34 | 4 | 5,356 | Ken Holtzman | Sonny Siebert | Sonny Siebert | Ken Holtzman | Steve Foucault | 332 | 269 | 63 |
| 1973-06-26 | @ TEX | 73 | W 6-2 | 39-34 | 3 | 6,238 | Dave Hamilton | Jim Merritt | Dave Hamilton | Jim Merritt | Rollie Fingers | 338 | 271 | 67 |
| 1973-06-27 | vs KCA | 74 | W 3-2 | 40-34 | 2 | 7,990 | Catfish Hunter | Paul Splittorff | Catfish Hunter | Paul Splittorff | | 341 | 273 | 68 |
| 1973-06-28 | vs KCA | 75 | W 3-2 | 41-34 | 1 | 5,665 | Vida Blue | Steve Busby | Vida Blue | Steve Busby | Rollie Fingers | 344 | 275 | 69 |
| 1973-06-29 | vs CHA | 76 | L 3-4 | 41-35 | 2 | 10,963 | Ken Holtzman | Stan Bahnsen | Stan Bahnsen | Ken Holtzman | Cy Acosta | 347 | 279 | 68 |
| 1973-06-30 | vs CHA | 77 | W 3-2 | 42-35 | 1 | 20,811 | Dave Hamilton | Wilbur Wood | Dave Hamilton | Wilbur Wood | Darold Knowles | 350 | 281 | 69 |
| 1973-07-01 | vs CHA | 78 | W 6-4 | 44-35 | 1 | 0 | Catfish Hunter | Eddie Fisher | Catfish Hunter | Eddie Fisher | Darold Knowles | 356 | 285 | 71 |
| 1973-07-01 | vs CHA | 79 | W 3-0 | 44-35 | 1 | 28,467 | Blue Moon Odom | Bart Johnson | Blue Moon Odom | Bart Johnson | Rollie Fingers | 359 | 285 | 74 |
| 1973-07-02 | vs CAL | 80 | L 2-4 | 44-36 | 2 | 33,407 | Vida Blue | Clyde Wright | Clyde Wright | Vida Blue | Steve Barber | 361 | 289 | 72 |
| 1973-07-03 | vs CAL | 81 | W 3-0 | 45-36 | 1 | 7,104 | Ken Holtzman | Nolan Ryan | Ken Holtzman | Nolan Ryan | | 364 | 289 | 75 |
| 1973-07-04 | vs CAL | 82 | L 1-3 | 45-37 | 1 | 36,741 | Dave Hamilton | Bill Singer | Bill Singer | Dave Hamilton | Dave Sells | 365 | 292 | 73 |
| 1973-07-06 | @ BAL | 83 | W 7-5 | 46-38 | 1 | 0 | Catfish Hunter | Jim Palmer | Catfish Hunter | Jim Palmer | Rollie Fingers | 372 | 297 | 75 |
| 1973-07-06 | @ BAL | 84 | L 3-5 | 46-38 | 1 | 23,320 | Vida Blue | Dave McNally | Dave McNally | Vida Blue | Eddie Watt | 375 | 302 | 73 |
| 1973-07-07 | @ BAL | 85 | W 5-4 | 47-38 | 1 | 42,180 | Ken Holtzman | Mike Cuellar | Ken Holtzman | Mike Cuellar | Darold Knowles | 380 | 306 | 74 |
| 1973-07-08 | @ BAL | 86 | W 6-5 | 48-38 | 1 | 18,267 | Dave Hamilton | Jesse Jefferson | Rollie Fingers | Bob Reynolds | | 386 | 311 | 75 |
| 1973-07-10 | @ CLE | 87 | L 5-7 | 48-39 | 1 | 6,388 | Blue Moon Odom | Dick Tidrow | Dick Tidrow | Darold Knowles | | 391 | 318 | 73 |
| 1973-07-11 | @ CLE | 88 | W 9-3 | 49-39 | 1 | 8,627 | Catfish Hunter | Gaylord Perry | Catfish Hunter | Gaylord Perry | | 400 | 321 | 79 |
| 1973-07-12 | @ MIL | 89 | W 8-4 | 50-39 | 1 | 19,309 | Vida Blue | Jim Slaton | Rollie Fingers | Jim Slaton | | 408 | 325 | 83 |
| 1973-07-13 | @ MIL | 90 | W 13-4 | 51-39 | 1 | 33,747 | Ken Holtzman | Skip Lockwood | Ken Holtzman | Skip Lockwood | Horacio Pina | 421 | 329 | 92 |
| 1973-07-14 | @ MIL | 91 | L 1-5 | 51-40 | 1 | 23,389 | Dave Hamilton | Jim Colborn | Jim Colborn | Dave Hamilton | | 422 | 334 | 88 |
| 1973-07-15 | @ MIL | 92 | W 8-5 | 52-40 | 1 | 17,791 | Blue Moon Odom | Jerry Bell | Rollie Fingers | Chris Short | | 430 | 339 | 91 |
| 1973-07-16 | vs BAL | 93 | L 5-7 | 52-41 | 1 | 43,571 | Catfish Hunter | Jesse Jefferson | Don Hood | Horacio Pina | | 435 | 346 | 89 |
| 1973-07-17 | vs BAL | 94 | W 3-1 | 53-41 | 1 | 7,276 | Vida Blue | Dave McNally | Vida Blue | Dave McNally | | 438 | 347 | 91 |
| 1973-07-18 | vs BAL | 95 | L 2-5 | 53-42 | 1 | 6,594 | Ken Holtzman | Jim Palmer | Jim Palmer | Ken Holtzman | | 440 | 352 | 88 |
| 1973-07-20 | vs CLE | 96 | W 6-5 | 54-42 | 1 | 9,236 | Catfish Hunter | Gaylord Perry | Catfish Hunter | Gaylord Perry | | 446 | 357 | 89 |
| 1973-07-21 | vs CLE | 97 | W 5-2 | 55-42 | 1 | 20,275 | Vida Blue | Milt Wilcox | Vida Blue | Milt Wilcox | | 451 | 359 | 92 |
| 1973-07-22 | vs CLE | 98 | W 5-2 | 56-42 | 1 | 10,628 | Ken Holtzman | Dick Bosman | Ken Holtzman | Dick Bosman | | 456 | 361 | 95 |
| 1973-07-26 | @ MIN | 99 | L 1-5 | 56-44 | 1 | 0 | Vida Blue | Dick Woodson | Dick Woodson | Vida Blue | Ray Corbin | 457 | 366 | 91 |
| 1973-07-26 | @ MIN | 100 | L 5-7 | 56-44 | 1 | 26,679 | Ken Holtzman | Jim Kaat | Ray Corbin | Rollie Fingers | | 462 | 373 | 89 |
| 1973-07-27 | @ MIN | 101 | L 2-8 | 56-45 | 1 | 11,098 | Dave Hamilton | Bert Blyleven | Bert Blyleven | Dave Hamilton | | 464 | 381 | 83 |
| 1973-07-28 | vs TEX | 102 | W 6-4 | 57-45 | 1 | 9,073 | Blue Moon Odom | Steve Dunning | Darold Knowles | Bill Gogolewski | | 470 | 385 | 85 |
| 1973-07-29 | vs TEX | 103 | L 0-3 | 58-46 | 1 | 0 | Paul Lindblad | Jackie Brown | Jackie Brown | Paul Lindblad | | 470 | 388 | 82 |
| 1973-07-29 | vs TEX | 104 | W 7-4 | 58-46 | 1 | 11,144 | Glenn Abbott | Don Durham | Dave Hamilton | Don Durham | Horacio Pina | 477 | 392 | 85 |
| 1973-07-30 | vs TEX | 105 | L 0-6 | 58-47 | 1 | 21,606 | Vida Blue | Jim Bibby | Jim Bibby | Vida Blue | | 477 | 398 | 79 |
| 1973-07-31 | vs MIN | 106 | W 4-3 | 59-47 | 1 | 5,670 | Ken Holtzman | Dick Woodson | Ken Holtzman | Bill Hands | | 481 | 401 | 80 |
| 1973-08-01 | vs MIN | 107 | W 6-2 | 60-47 | 1 | 5,702 | Darold Knowles | Bert Blyleven | Darold Knowles | Bert Blyleven | Rollie Fingers | 487 | 403 | 84 |
| 1973-08-02 | vs MIN | 108 | L 3-6 | 60-48 | 2 | 5,218 | Paul Lindblad | Joe Decker | Joe Decker | Paul Lindblad | Bill Hands | 490 | 409 | 81 |
| 1973-08-03 | @ CAL | 109 | W 2-1 | 61-48 | 2 | 15,712 | Vida Blue | Bill Singer | Vida Blue | Bill Singer | Rollie Fingers | 492 | 410 | 82 |
| 1973-08-04 | @ CAL | 110 | W 3-2 | 62-48 | 2 | 17,945 | Ken Holtzman | Clyde Wright | Ken Holtzman | Clyde Wright | Horacio Pina | 495 | 412 | 83 |
| 1973-08-05 | @ CAL | 111 | W 6-2 | 63-48 | 1 | 13,158 | Darold Knowles | Rudy May | Rollie Fingers | Rudy May | | 501 | 414 | 87 |
| 1973-08-07 | @ DET | 112 | W 8-4 | 64-49 | 2 | 0 | Vida Blue | Mickey Lolich | Vida Blue | Mickey Lolich | Darold Knowles | 509 | 418 | 91 |
| 1973-08-07 | @ DET | 113 | L 0-2 | 64-49 | 2 | 42,007 | Paul Lindblad | Jim Perry | Jim Perry | Paul Lindblad | John Hiller | 509 | 420 | 89 |
| 1973-08-08 | @ DET | 114 | L 2-3 | 64-50 | 2 | 28,000 | Ken Holtzman | Woodie Fryman | Woodie Fryman | Ken Holtzman | John Hiller | 511 | 423 | 88 |
| 1973-08-10 | @ NYA | 115 | L 9-10 | 64-51 | 2 | 29,652 | Darold Knowles | Pat Dobson | Lindy McDaniel | Darold Knowles | Tom Buskey | 520 | 433 | 87 |
| 1973-08-11 | @ NYA | 116 | W 7-3 | 65-51 | 2 | 46,293 | Vida Blue | Mel Stottlemyre | Vida Blue | Mel Stottlemyre | | 527 | 436 | 91 |
| 1973-08-12 | @ NYA | 117 | W 13-12 | 66-51 | 2 | 32,951 | Ken Holtzman | Sam McDowell | Darold Knowles | Tom Buskey | Rollie Fingers | 540 | 448 | 92 |
| 1973-08-13 | @ BOS | 118 | W 3-1 | 67-51 | 2 | 29,960 | Blue Moon Odom | Luis Tiant | Blue Moon Odom | Luis Tiant | Rollie Fingers | 543 | 449 | 94 |
| 1973-08-14 | @ BOS | 119 | W 1-0 | 68-51 | 2 | 29,084 | Darold Knowles | Bill Lee | Darold Knowles | Bill Lee | | 544 | 449 | 95 |
| 1973-08-16 | @ BOS | 120 | W 6-3 | 69-51 | 1 | 20,424 | Vida Blue | John Curtis | Vida Blue | John Curtis | | 550 | 452 | 98 |
| 1973-08-17 | vs MIL | 121 | W 3-2 | 70-51 | 1 | 8,248 | Ken Holtzman | Jim Colborn | Ken Holtzman | Jim Colborn | Rollie Fingers | 553 | 454 | 99 |
| 1973-08-18 | vs MIL | 122 | W 6-3 | 71-51 | 1 | 10,672 | Blue Moon Odom | Jim Slaton | Rollie Fingers | Jim Slaton | | 559 | 457 | 102 |
| 1973-08-19 | vs MIL | 123 | W 6-4 | 72-51 | 1 | 9,119 | Catfish Hunter | Bill Parsons | Horacio Pina | Skip Lockwood | | 565 | 461 | 104 |
| 1973-08-20 | vs DET | 124 | W 7-2 | 73-51 | 1 | 41,969 | Vida Blue | Jim Perry | Vida Blue | Jim Perry | | 572 | 463 | 109 |
| 1973-08-21 | vs DET | 125 | L 4-6 | 73-52 | 1 | 8,250 | Ken Holtzman | Woodie Fryman | John Hiller | Ken Holtzman | | 576 | 469 | 107 |
| 1973-08-22 | vs DET | 126 | W 7-3 | 74-52 | 1 | 7,159 | Blue Moon Odom | Joe Coleman | Blue Moon Odom | Joe Coleman | Rollie Fingers | 583 | 472 | 111 |
| 1973-08-24 | vs NYA | 127 | W 5-1 | 75-52 | 1 | 12,007 | Catfish Hunter | Doc Medich | Catfish Hunter | Doc Medich | Darold Knowles | 588 | 473 | 115 |
| 1973-08-25 | vs NYA | 128 | W 2-0 | 76-52 | 1 | 15,607 | Vida Blue | Pat Dobson | Vida Blue | Pat Dobson | | 590 | 473 | 117 |
| 1973-08-26 | vs NYA | 129 | W 1-0 | 77-52 | 1 | 15,154 | Ken Holtzman | Mel Stottlemyre | Ken Holtzman | Mel Stottlemyre | | 591 | 473 | 118 |
| 1973-08-27 | vs BOS | 130 | L 2-5 | 77-53 | 1 | 32,444 | Blue Moon Odom | Roger Moret | Roger Moret | Blue Moon Odom | | 593 | 478 | 115 |
| 1973-08-28 | vs BOS | 131 | W 6-1 | 78-53 | 1 | 7,284 | Catfish Hunter | Dick Pole | Catfish Hunter | Dick Pole | Rollie Fingers | 599 | 479 | 120 |
| 1973-08-29 | vs BOS | 132 | L 4-6 | 78-54 | 1 | 7,631 | Vida Blue | Bill Lee | Bill Lee | Vida Blue | Bobby Bolin | 603 | 485 | 118 |
| 1973-08-31 | @ KCA | 133 | W 10-7 | 79-54 | 1 | 36,242 | Ken Holtzman | Paul Splittorff | Rollie Fingers | Doug Bird | | 613 | 492 | 121 |
| 1973-09-01 | @ KCA | 134 | L 9-10 | 79-55 | 1 | 38,468 | Catfish Hunter | Al Fitzmorris | Joe Hoerner | Darold Knowles | | 622 | 502 | 120 |
| 1973-09-02 | @ KCA | 135 | L 5-6 | 79-56 | 1 | 35,466 | Vida Blue | Steve Busby | Steve Busby | Vida Blue | Gene Garber | 627 | 508 | 119 |
| 1973-09-03 | @ CAL | 136 | L 1-3 | 79-57 | 1 | 14,182 | Blue Moon Odom | Nolan Ryan | Nolan Ryan | Blue Moon Odom | | 628 | 511 | 117 |
| 1973-09-04 | @ CAL | 137 | W 4-3 | 80-57 | 1 | 7,198 | Ken Holtzman | Bill Singer | Ken Holtzman | Bill Singer | Horacio Pina | 632 | 514 | 118 |
| 1973-09-05 | @ CAL | 138 | W 11-8 | 81-57 | 1 | 9,277 | Catfish Hunter | Rudy May | Catfish Hunter | Rudy May | Rollie Fingers | 643 | 522 | 121 |
| 1973-09-06 | @ CAL | 139 | W 6-4 | 82-57 | 1 | 26,104 | Vida Blue | Clyde Wright | Vida Blue | Clyde Wright | Paul Lindblad | 649 | 526 | 123 |
| 1973-09-07 | @ TEX | 140 | L 8-10 | 82-58 | 1 | 5,014 | Blue Moon Odom | David Clyde | Bill Gogolewski | Darold Knowles | Jim Merritt | 657 | 536 | 121 |
| 1973-09-08 | @ TEX | 141 | L 3-4 | 82-59 | 1 | 6,086 | Ken Holtzman | Rick Henninger | Jackie Brown | Paul Lindblad | | 660 | 540 | 120 |
| 1973-09-09 | @ TEX | 142 | L 3-5 | 82-60 | 1 | 4,294 | Catfish Hunter | Jim Bibby | Jim Bibby | Catfish Hunter | Lloyd Allen | 663 | 545 | 118 |
| 1973-09-10 | vs KCA | 143 | W 13-0 | 83-60 | 1 | 47,570 | Vida Blue | Steve Busby | Vida Blue | Steve Busby | | 676 | 545 | 131 |
| 1973-09-11 | vs KCA | 144 | W 3-1 | 84-60 | 1 | 12,354 | Glenn Abbott | Gene Garber | Glenn Abbott | Gene Garber | | 679 | 546 | 133 |
| 1973-09-12 | vs KCA | 145 | L 0-5 | 84-61 | 1 | 10,788 | Ken Holtzman | Paul Splittorff | Paul Splittorff | Ken Holtzman | Doug Bird | 679 | 551 | 128 |
| 1973-09-14 | vs TEX | 146 | W 5-1 | 85-61 | 1 | 4,690 | Catfish Hunter | Jim Bibby | Catfish Hunter | Lloyd Allen | | 684 | 552 | 132 |
| 1973-09-15 | vs TEX | 147 | W 3-1 | 86-61 | 1 | 8,360 | Vida Blue | Pete Broberg | Vida Blue | Pete Broberg | Rollie Fingers | 687 | 553 | 134 |
| 1973-09-16 | vs TEX | 148 | W 9-4 | 87-61 | 1 | 10,907 | Glenn Abbott | Steve Dunning | Blue Moon Odom | Steve Dunning | | 696 | 557 | 139 |
| 1973-09-17 | vs CAL | 149 | W 3-2 | 88-61 | 1 | 12,953 | Ken Holtzman | Rudy May | Rollie Fingers | Rudy May | | 699 | 559 | 140 |
| 1973-09-18 | vs CAL | 150 | W 5-4 | 89-61 | 1 | 3,781 | Catfish Hunter | Andy Hassler | Catfish Hunter | Andy Hassler | Rollie Fingers | 704 | 563 | 141 |
| 1973-09-19 | @ MIN | 151 | W 3-0 | 90-61 | 1 | 5,202 | Vida Blue | Joe Decker | Vida Blue | Joe Decker | | 707 | 563 | 144 |
| 1973-09-20 | @ MIN | 152 | L 3-4 | 90-63 | 1 | 0 | Blue Moon Odom | Bill Hands | Bill Campbell | Blue Moon Odom | | 710 | 567 | 143 |
| 1973-09-20 | @ MIN | 153 | L 4-5 | 90-63 | 1 | 5,388 | Darold Knowles | Danny Fife | Vic Albury | Rollie Fingers | | 714 | 572 | 142 |
| 1973-09-21 | @ MIN | 154 | L 3-8 | 90-64 | 1 | 3,000 | Ken Holtzman | Ray Corbin | Ray Corbin | Ken Holtzman | | 717 | 580 | 137 |
| 1973-09-22 | @ CHA | 155 | W 9-3 | 91-64 | 1 | 11,145 | Catfish Hunter | Stan Bahnsen | Catfish Hunter | Stan Bahnsen | Darold Knowles | 726 | 583 | 143 |
| 1973-09-23 | @ CHA | 156 | W 10-5 | 92-64 | 1 | 11,160 | Vida Blue | Wilbur Wood | Vida Blue | Wilbur Wood | Horacio Pina | 736 | 588 | 148 |
| 1973-09-24 | vs MIN | 157 | L 6-7 | 92-65 | 1 | 18,556 | Blue Moon Odom | Danny Fife | Bill Hands | Rollie Fingers | Bill Campbell | 742 | 595 | 147 |
| 1973-09-25 | vs MIN | 158 | L 4-9 | 92-66 | 1 | 3,713 | Chuck Dobson | Ray Corbin | Ray Corbin | Chuck Dobson | Bill Campbell | 746 | 604 | 142 |
| 1973-09-26 | vs MIN | 159 | L 1-4 | 92-67 | 1 | 3,521 | Catfish Hunter | Bert Blyleven | Bert Blyleven | Catfish Hunter | | 747 | 608 | 139 |
| 1973-09-28 | vs CHA | 160 | W 4-1 | 93-67 | 1 | 5,355 | Vida Blue | Jim McGlothlin | Paul Lindblad | Jim McGlothlin | Rollie Fingers | 751 | 609 | 142 |
| 1973-09-29 | vs CHA | 161 | W 7-5 | 94-67 | 1 | 6,481 | Ken Holtzman | Terry Forster | Ken Holtzman | Terry Forster | Rollie Fingers | 758 | 614 | 144 |
| 1973-09-30 | vs CHA | 162 | L 0-1 | 94-68 | 1 | 7,422 | Catfish Hunter | Steve Stone | Steve Stone | Darold Knowles | Cy Acosta | 758 | 615 | 143 |