| 1973-04-06 | @ OAK | 1 | W 8-3 | 1-0 | 1 | 38,207 | Bert Blyleven | Catfish Hunter | Bert Blyleven | Catfish Hunter | | 8 | 3 | 5 |
| 1973-04-07 | @ OAK | 2 | W 5-3 | 2-0 | 2 | 7,246 | Bill Hands | Blue Moon Odom | Bill Hands | Blue Moon Odom | Ken Sanders | 13 | 6 | 7 |
| 1973-04-08 | @ OAK | 3 | W 4-2 | 3-0 | 2 | 8,919 | Jim Kaat | Ken Holtzman | Jim Kaat | Ken Holtzman | Ray Corbin | 17 | 8 | 9 |
| 1973-04-10 | @ CAL | 4 | L 2-4 | 3-1 | 3 | 6,319 | Bert Blyleven | Bill Singer | Bill Singer | Bert Blyleven | | 19 | 12 | 7 |
| 1973-04-11 | @ CAL | 5 | L 1-4 | 3-2 | 2 | 6,946 | Bill Hands | Nolan Ryan | Nolan Ryan | Bill Hands | | 20 | 16 | 4 |
| 1973-04-13 | vs OAK | 6 | W 8-4 | 4-2 | 2 | 13,040 | Jim Kaat | Blue Moon Odom | Jim Kaat | Blue Moon Odom | Ray Corbin | 28 | 20 | 8 |
| 1973-04-14 | vs OAK | 7 | L 1-2 | 4-3 | 2 | 10,711 | Bert Blyleven | Ken Holtzman | Ken Holtzman | Bert Blyleven | | 29 | 22 | 7 |
| 1973-04-17 | vs CAL | 8 | W 10-5 | 5-3 | 2 | 3,856 | Jim Kaat | Bill Singer | Jim Kaat | Bill Singer | Ken Sanders | 39 | 27 | 12 |
| 1973-04-18 | vs CAL | 9 | L 2-3 | 5-4 | 2 | 5,088 | Bert Blyleven | Nolan Ryan | Nolan Ryan | Bert Blyleven | | 41 | 30 | 11 |
| 1973-04-20 | vs TEX | 10 | W 5-1 | 6-4 | 2 | 4,600 | Bill Hands | Rich Hand | Bill Hands | Rich Hand | | 46 | 31 | 15 |
| 1973-04-21 | vs TEX | 11 | W 5-4 | 7-4 | 2 | 9,397 | Jim Kaat | Pete Broberg | Ken Sanders | Steve Foucault | | 51 | 35 | 16 |
| 1973-04-22 | vs TEX | 12 | W 6-4 | 8-4 | 2 | 4,415 | Bert Blyleven | Dick Bosman | Bert Blyleven | Dick Bosman | Ray Corbin | 57 | 39 | 18 |
| 1973-04-24 | @ BOS | 13 | W 6-4 | 9-4 | 1 | 10,859 | Dick Woodson | Marty Pattin | Dick Woodson | Marty Pattin | Ken Sanders | 63 | 43 | 20 |
| 1973-04-25 | @ BOS | 14 | L 3-4 | 9-5 | 2 | 9,529 | Bill Hands | Lynn McGlothen | Bill Lee | Ray Corbin | Bobby Bolin | 66 | 47 | 19 |
| 1973-04-28 | @ NYA | 15 | L 3-11 | 9-6 | 3 | 6,461 | Jim Kaat | Doc Medich | Doc Medich | Jim Kaat | | 69 | 58 | 11 |
| 1973-04-29 | @ NYA | 16 | L 3-6 | 9-8 | 3 | 0 | Bert Blyleven | Mel Stottlemyre | Mel Stottlemyre | Bert Blyleven | | 72 | 64 | 8 |
| 1973-04-29 | @ NYA | 17 | L 1-11 | 9-8 | 3 | 28,123 | Bill Hands | Fritz Peterson | Fritz Peterson | Bill Hands | Lindy McDaniel | 73 | 75 | -2 |
| 1973-05-02 | vs CLE | 18 | L 4-8 | 9-9 | 4 | 4,756 | Dick Woodson | Brent Strom | Ray Lamb | Ken Sanders | Jerry Johnson | 77 | 83 | -6 |
| 1973-05-04 | vs BOS | 19 | W 9-6 | 10-9 | 4 | 7,285 | Jim Kaat | Marty Pattin | Jim Kaat | Marty Pattin | Ken Sanders | 86 | 89 | -3 |
| 1973-05-05 | vs BOS | 20 | L 1-5 | 10-10 | 4 | 6,996 | Bert Blyleven | Bill Lee | Bill Lee | Bert Blyleven | Bob Veale | 87 | 94 | -7 |
| 1973-05-06 | vs BOS | 21 | W 10-3 | 11-10 | 4 | 7,431 | Bill Hands | Luis Tiant | Bill Hands | Luis Tiant | | 97 | 97 | 0 |
| 1973-05-08 | vs NYA | 22 | L 4-14 | 11-11 | 4 | 6,041 | Dick Woodson | Mel Stottlemyre | Mel Stottlemyre | Dick Woodson | Lindy McDaniel | 101 | 111 | -10 |
| 1973-05-09 | vs NYA | 23 | L 0-2 | 11-12 | 5 | 5,099 | Jim Kaat | Fritz Peterson | Fritz Peterson | Jim Kaat | Sparky Lyle | 101 | 113 | -12 |
| 1973-05-11 | @ KCA | 24 | L 2-6 | 11-13 | 5 | 19,565 | Bert Blyleven | Bruce Dal Canton | Bruce Dal Canton | Bert Blyleven | | 103 | 119 | -16 |
| 1973-05-12 | @ KCA | 25 | L 2-4 | 11-14 | 5 | 23,948 | Bill Hands | Paul Splittorff | Paul Splittorff | Bill Hands | | 105 | 123 | -18 |
| 1973-05-13 | @ KCA | 26 | W 5-0 | 12-14 | 5 | 25,661 | Dick Woodson | Steve Busby | Dick Woodson | Steve Busby | | 110 | 123 | -13 |
| 1973-05-14 | @ TEX | 27 | L 6-7 | 13-15 | 5 | 0 | Jim Kaat | Mike Paul | Charlie Hudson | Ken Sanders | | 116 | 130 | -14 |
| 1973-05-14 | @ TEX | 28 | W 6-4 | 13-15 | 5 | 5,072 | Ray Corbin | Rich Hand | Dave Goltz | Steve Foucault | | 122 | 134 | -12 |
| 1973-05-15 | @ TEX | 29 | W 9-5 | 14-15 | 5 | 3,697 | Bert Blyleven | Don Stanhouse | Bert Blyleven | Bill Gogolewski | | 131 | 139 | -8 |
| 1973-05-16 | vs CHA | 30 | W 8-6 | 15-15 | 5 | 6,119 | Bill Hands | Eddie Fisher | Bill Hands | Eddie Fisher | Ken Sanders | 139 | 145 | -6 |
| 1973-05-17 | vs CHA | 31 | L 4-5 | 15-16 | 5 | 7,577 | Dick Woodson | Wilbur Wood | Wilbur Wood | Dick Woodson | Cy Acosta | 143 | 150 | -7 |
| 1973-05-18 | @ CHA | 32 | W 3-0 | 16-16 | 5 | 20,712 | Jim Kaat | Rich Gossage | Jim Kaat | Rich Gossage | | 146 | 150 | -4 |
| 1973-05-19 | @ CHA | 33 | W 8-3 | 17-16 | 5 | 43,297 | Bert Blyleven | Stan Bahnsen | Bert Blyleven | Stan Bahnsen | | 154 | 153 | 1 |
| 1973-05-20 | @ CHA | 34 | L 3-9 | 18-17 | 4 | 0 | Bill Hands | Wilbur Wood | Wilbur Wood | Bill Hands | | 157 | 162 | -5 |
| 1973-05-20 | @ CHA | 35 | W 3-0 | 18-17 | 4 | 55,555 | Ray Corbin | Eddie Fisher | Ray Corbin | Eddie Fisher | Ken Sanders | 160 | 162 | -2 |
| 1973-05-22 | vs KCA | 36 | W 8-7 | 19-17 | 5 | 4,951 | Dick Woodson | Wayne Simpson | Dick Woodson | Wayne Simpson | Ken Sanders | 168 | 169 | -1 |
| 1973-05-23 | vs KCA | 37 | W 8-6 | 20-17 | 5 | 6,444 | Jim Kaat | Steve Busby | Dave Goltz | Steve Busby | Ray Corbin | 176 | 175 | 1 |
| 1973-05-24 | vs KCA | 38 | W 2-0 | 21-17 | 2 | 4,585 | Bert Blyleven | Dick Drago | Bert Blyleven | Dick Drago | | 178 | 175 | 3 |
| 1973-05-25 | vs KCA | 39 | L 4-5 | 21-18 | 4 | 6,890 | Bill Hands | Paul Splittorff | Bruce Dal Canton | Jim Strickland | Norm Angelini | 182 | 180 | 2 |
| 1973-05-26 | vs BAL | 40 | L 2-7 | 21-19 | 4 | 7,754 | Dick Woodson | Mike Cuellar | Mike Cuellar | Dick Woodson | | 184 | 187 | -3 |
| 1973-05-28 | vs BAL | 41 | W 10-3 | 22-19 | 4 | 13,522 | Jim Kaat | Doyle Alexander | Jim Kaat | Doyle Alexander | | 194 | 190 | 4 |
| 1973-05-29 | @ MIL | 42 | W 1-0 | 23-19 | 2 | 4,982 | Bert Blyleven | Jim Slaton | Bert Blyleven | Jim Slaton | | 195 | 190 | 5 |
| 1973-05-30 | @ MIL | 43 | W 4-0 | 24-19 | 2 | 5,437 | Bill Hands | Bill Parsons | Bill Hands | Bill Parsons | | 199 | 190 | 9 |
| 1973-05-31 | @ MIL | 44 | W 4-2 | 25-19 | 2 | 8,939 | Dick Woodson | Jim Colborn | Dick Woodson | Jim Colborn | Ken Sanders | 203 | 192 | 11 |
| 1973-06-01 | vs DET | 45 | L 3-8 | 25-20 | 2 | 19,950 | Jim Kaat | Joe Coleman | Joe Coleman | Jim Kaat | John Hiller | 206 | 200 | 6 |
| 1973-06-02 | vs DET | 46 | W 3-2 | 26-20 | 2 | 13,998 | Bert Blyleven | Woodie Fryman | Ken Sanders | Woodie Fryman | | 209 | 202 | 7 |
| 1973-06-03 | vs DET | 47 | L 2-8 | 26-21 | 3 | 35,815 | Bill Hands | Mickey Lolich | Mickey Lolich | Bill Hands | | 211 | 210 | 1 |
| 1973-06-06 | @ CLE | 48 | W 7-3 | 28-21 | 2 | 0 | Jim Kaat | Dick Tidrow | Ray Corbin | Jerry Johnson | | 218 | 213 | 5 |
| 1973-06-06 | @ CLE | 49 | W 13-9 | 28-21 | 2 | 2,033 | Joe Decker | Ray Lamb | Joe Decker | Ray Lamb | Dave Goltz | 231 | 222 | 9 |
| 1973-06-08 | @ BAL | 50 | W 2-0 | 29-21 | 2 | 21,208 | Bert Blyleven | Dave McNally | Bert Blyleven | Dave McNally | | 233 | 222 | 11 |
| 1973-06-09 | @ BAL | 51 | L 4-7 | 29-22 | 2 | 19,603 | Bill Hands | Mike Cuellar | Bob Reynolds | Bill Hands | Grant Jackson | 237 | 229 | 8 |
| 1973-06-10 | @ BAL | 52 | W 11-4 | 30-22 | 2 | 18,210 | Dick Woodson | Doyle Alexander | Dick Woodson | Doyle Alexander | Ray Corbin | 248 | 233 | 15 |
| 1973-06-11 | vs MIL | 53 | L 6-10 | 30-23 | 2 | 10,307 | Jim Kaat | Bill Parsons | Bill Parsons | Jim Kaat | Frank Linzy | 254 | 243 | 11 |
| 1973-06-12 | vs MIL | 54 | L 3-6 | 30-24 | 2 | 12,091 | Bert Blyleven | Jerry Bell | Bill Champion | Bert Blyleven | Frank Linzy | 257 | 249 | 8 |
| 1973-06-13 | vs MIL | 55 | L 3-4 | 30-25 | 2 | 9,527 | Joe Decker | Jim Colborn | Jim Colborn | Ray Corbin | | 260 | 253 | 7 |
| 1973-06-15 | @ DET | 56 | W 13-6 | 31-25 | 2 | 34,926 | Dick Woodson | Jim Perry | Jim Kaat | Jim Perry | | 273 | 259 | 14 |
| 1973-06-16 | @ DET | 57 | W 5-0 | 32-25 | 2 | 23,428 | Bert Blyleven | Joe Coleman | Bert Blyleven | Joe Coleman | | 278 | 259 | 19 |
| 1973-06-17 | @ DET | 58 | L 0-6 | 32-26 | 2 | 52,622 | Joe Decker | Mickey Lolich | Mickey Lolich | Joe Decker | | 278 | 265 | 13 |
| 1973-06-18 | vs TEX | 59 | L 4-7 | 32-27 | 2 | 8,073 | Bill Hands | Pete Broberg | Pete Broberg | Bill Hands | Mike Paul | 282 | 272 | 10 |
| 1973-06-19 | vs TEX | 60 | W 7-3 | 33-27 | 1 | 7,022 | Jim Kaat | Jim Bibby | Jim Kaat | Jim Bibby | Ray Corbin | 289 | 275 | 14 |
| 1973-06-20 | vs TEX | 61 | L 0-3 | 33-28 | 2 | 6,318 | Dick Woodson | Sonny Siebert | Sonny Siebert | Dick Woodson | | 289 | 278 | 11 |
| 1973-06-21 | vs CAL | 62 | W 1-0 | 34-28 | 2 | 8,819 | Bert Blyleven | Clyde Wright | Bert Blyleven | Clyde Wright | | 290 | 278 | 12 |
| 1973-06-22 | vs CAL | 63 | L 3-4 | 34-29 | 2 | 14,237 | Joe Decker | Rudy May | Dave Sells | Joe Decker | | 293 | 282 | 11 |
| 1973-06-23 | vs CAL | 64 | L 1-3 | 34-30 | 4 | 11,631 | Jim Kaat | Bill Singer | Rich Hand | Jim Kaat | | 294 | 285 | 9 |
| 1973-06-24 | vs CAL | 65 | W 5-1 | 35-31 | 4 | 0 | Dick Woodson | Andy Hassler | Dick Woodson | Andy Hassler | Ray Corbin | 299 | 286 | 13 |
| 1973-06-24 | vs CAL | 66 | L 0-3 | 35-31 | 4 | 20,153 | Dave Goltz | Clyde Wright | Clyde Wright | Ray Corbin | Steve Barber | 299 | 289 | 10 |
| 1973-06-25 | @ CHA | 67 | L 2-3 | 35-32 | 5 | 16,098 | Bert Blyleven | Stan Bahnsen | Stan Bahnsen | Bert Blyleven | Cy Acosta | 301 | 292 | 9 |
| 1973-06-26 | @ CHA | 68 | W 4-0 | 36-32 | 5 | 19,168 | Joe Decker | Wilbur Wood | Joe Decker | Wilbur Wood | | 305 | 292 | 13 |
| 1973-06-27 | @ TEX | 69 | L 3-4 | 36-33 | 5 | 35,698 | Jim Kaat | David Clyde | David Clyde | Jim Kaat | Bill Gogolewski | 308 | 296 | 12 |
| 1973-06-28 | @ TEX | 70 | W 4-0 | 37-33 | 4 | 3,992 | Dick Woodson | Pete Broberg | Dick Woodson | Pete Broberg | | 312 | 296 | 16 |
| 1973-06-29 | @ CAL | 71 | W 4-0 | 38-33 | 3 | 15,212 | Bert Blyleven | Nolan Ryan | Bert Blyleven | Nolan Ryan | | 316 | 296 | 20 |
| 1973-06-30 | @ CAL | 72 | W 6-3 | 39-33 | 2 | 25,017 | Joe Decker | Andy Hassler | Joe Decker | Andy Hassler | Ray Corbin | 322 | 299 | 23 |
| 1973-07-01 | @ CAL | 73 | W 2-1 | 40-33 | 2 | 27,068 | Jim Kaat | Bill Singer | Jim Kaat | Bill Singer | | 324 | 300 | 24 |
| 1973-07-02 | @ KCA | 74 | W 5-2 | 41-33 | 1 | 11,724 | Dick Woodson | Steve Busby | Dick Woodson | Steve Busby | Ray Corbin | 329 | 302 | 27 |
| 1973-07-03 | @ KCA | 75 | L 6-7 | 41-34 | 2 | 23,126 | Bert Blyleven | Mark Littell | Gene Garber | Ken Sanders | | 335 | 309 | 26 |
| 1973-07-04 | vs KCA | 76 | L 4-5 | 41-35 | 2 | 45,890 | Eddie Bane | Dick Drago | Dick Drago | Ray Corbin | Gene Garber | 339 | 314 | 25 |
| 1973-07-05 | vs KCA | 77 | L 10-12 | 41-36 | 2 | 8,787 | Joe Decker | Paul Splittorff | Paul Splittorff | Joe Decker | Gene Garber | 349 | 326 | 23 |
| 1973-07-06 | vs NYA | 78 | L 2-5 | 41-37 | 3 | 16,434 | Jim Kaat | Fred Beene | Fred Beene | Jim Kaat | Sparky Lyle | 351 | 331 | 20 |
| 1973-07-07 | vs NYA | 79 | W 9-1 | 43-37 | 3 | 17,810 | Bert Blyleven | Fritz Peterson | Bert Blyleven | Fritz Peterson | | 360 | 332 | 28 |
| 1973-07-07 | vs NYA | 80 | W 6-2 | 43-37 | 3 | 10,719 | Dick Woodson | Pat Dobson | Dick Woodson | Pat Dobson | Ray Corbin | 366 | 334 | 32 |
| 1973-07-08 | vs NYA | 81 | L 0-7 | 43-38 | 4 | 27,425 | Eddie Bane | Mel Stottlemyre | Mel Stottlemyre | Eddie Bane | | 366 | 341 | 25 |
| 1973-07-09 | vs BOS | 82 | L 0-2 | 43-39 | 4 | 13,692 | Joe Decker | Bill Lee | Bill Lee | Joe Decker | | 366 | 343 | 23 |
| 1973-07-10 | vs BOS | 83 | L 1-2 | 43-40 | 5 | 11,907 | Jim Kaat | Luis Tiant | Luis Tiant | Jim Kaat | | 367 | 345 | 22 |
| 1973-07-11 | vs BOS | 84 | W 3-0 | 44-40 | 4 | 11,617 | Bert Blyleven | John Curtis | Bert Blyleven | John Curtis | | 370 | 345 | 25 |
| 1973-07-12 | vs CLE | 85 | W 8-4 | 45-41 | 3 | 0 | Dick Woodson | Milt Wilcox | Dave Goltz | Milt Wilcox | Ray Corbin | 378 | 349 | 29 |
| 1973-07-12 | vs CLE | 86 | L 4-7 | 45-41 | 3 | 11,054 | Eddie Bane | Brent Strom | Jerry Johnson | Ken Sanders | | 382 | 356 | 26 |
| 1973-07-13 | vs CLE | 87 | L 2-11 | 45-42 | 4 | 12,233 | Joe Decker | Dick Bosman | Dick Bosman | Joe Decker | | 384 | 367 | 17 |
| 1973-07-14 | vs CLE | 88 | L 0-3 | 45-43 | 4 | 15,427 | Jim Kaat | Dick Tidrow | Dick Tidrow | Jim Kaat | | 384 | 370 | 14 |
| 1973-07-15 | vs CLE | 89 | W 7-6 | 46-43 | 3 | 15,256 | Bert Blyleven | Gaylord Perry | Ray Corbin | Jerry Johnson | | 391 | 376 | 15 |
| 1973-07-17 | @ NYA | 90 | L 3-4 | 46-45 | 5 | 0 | Dick Woodson | Fritz Peterson | Sparky Lyle | Ray Corbin | | 394 | 380 | 14 |
| 1973-07-17 | @ NYA | 91 | L 1-4 | 46-45 | 5 | 25,562 | Eddie Bane | Pat Dobson | Pat Dobson | Eddie Bane | Sparky Lyle | 395 | 384 | 11 |
| 1973-07-18 | @ NYA | 92 | W 3-0 | 47-45 | 3 | 20,161 | Jim Kaat | Mel Stottlemyre | Jim Kaat | Mel Stottlemyre | | 398 | 384 | 14 |
| 1973-07-19 | @ BOS | 93 | W 6-2 | 48-45 | 3 | 21,359 | Joe Decker | Luis Tiant | Joe Decker | Luis Tiant | | 404 | 386 | 18 |
| 1973-07-20 | @ BOS | 94 | L 0-5 | 48-46 | 3 | 22,996 | Bert Blyleven | John Curtis | John Curtis | Bert Blyleven | | 404 | 391 | 13 |
| 1973-07-21 | @ BOS | 95 | L 2-3 | 48-47 | 3 | 19,492 | Dick Woodson | Marty Pattin | Marty Pattin | Dick Woodson | Roger Moret | 406 | 394 | 12 |
| 1973-07-22 | @ BOS | 96 | W 10-7 | 49-47 | 3 | 28,656 | Jim Kaat | Bill Lee | Jim Kaat | Bill Lee | Ray Corbin | 416 | 401 | 15 |
| 1973-07-26 | vs OAK | 97 | W 5-1 | 51-47 | 3 | 0 | Dick Woodson | Vida Blue | Dick Woodson | Vida Blue | Ray Corbin | 421 | 402 | 19 |
| 1973-07-26 | vs OAK | 98 | W 7-5 | 51-47 | 3 | 26,679 | Jim Kaat | Ken Holtzman | Ray Corbin | Rollie Fingers | | 428 | 407 | 21 |
| 1973-07-27 | vs OAK | 99 | W 8-2 | 52-47 | 3 | 11,098 | Bert Blyleven | Dave Hamilton | Bert Blyleven | Dave Hamilton | | 436 | 409 | 27 |
| 1973-07-28 | vs CHA | 100 | W 6-5 | 53-47 | 3 | 21,873 | Joe Decker | Bart Johnson | Joe Decker | Bart Johnson | Eddie Bane | 442 | 414 | 28 |
| 1973-07-29 | vs CHA | 101 | L 6-8 | 53-48 | 3 | 20,046 | Dave Goltz | Wilbur Wood | Wilbur Wood | Dave Goltz | Cy Acosta | 448 | 422 | 26 |
| 1973-07-30 | vs CHA | 102 | L 1-9 | 53-49 | 3 | 20,758 | Jim Kaat | Stan Bahnsen | Stan Bahnsen | Jim Kaat | | 449 | 431 | 18 |
| 1973-07-31 | @ OAK | 103 | L 3-4 | 53-50 | 3 | 5,670 | Dick Woodson | Ken Holtzman | Ken Holtzman | Bill Hands | | 452 | 435 | 17 |
| 1973-08-01 | @ OAK | 104 | L 2-6 | 53-51 | 3 | 5,702 | Bert Blyleven | Darold Knowles | Darold Knowles | Bert Blyleven | Rollie Fingers | 454 | 441 | 13 |
| 1973-08-02 | @ OAK | 105 | W 6-3 | 54-51 | 3 | 5,218 | Joe Decker | Paul Lindblad | Joe Decker | Paul Lindblad | Bill Hands | 460 | 444 | 16 |
| 1973-08-03 | vs KCA | 106 | L 2-4 | 54-52 | 3 | 20,024 | Jim Kaat | Al Fitzmorris | Al Fitzmorris | Jim Kaat | Doug Bird | 462 | 448 | 14 |
| 1973-08-04 | vs KCA | 107 | L 4-6 | 54-53 | 3 | 26,468 | Dick Woodson | Paul Splittorff | Gene Garber | Dick Woodson | | 466 | 454 | 12 |
| 1973-08-05 | vs KCA | 108 | W 7-1 | 55-53 | 3 | 15,311 | Bert Blyleven | Steve Busby | Bert Blyleven | Steve Busby | | 473 | 455 | 18 |
| 1973-08-07 | vs BAL | 109 | W 4-2 | 56-54 | 3 | 0 | Joe Decker | Jesse Jefferson | Joe Decker | Jesse Jefferson | Eddie Bane | 477 | 457 | 20 |
| 1973-08-07 | vs BAL | 110 | L 4-10 | 56-54 | 3 | 15,176 | Jim Kaat | Dave McNally | Dave McNally | Jim Kaat | Bob Reynolds | 481 | 467 | 14 |
| 1973-08-08 | vs BAL | 111 | L 1-6 | 56-55 | 3 | 13,502 | Dick Woodson | Jim Palmer | Jim Palmer | Dick Woodson | | 482 | 473 | 9 |
| 1973-08-09 | vs BAL | 112 | L 1-2 | 56-56 | 3 | 11,071 | Bert Blyleven | Mike Cuellar | Mike Cuellar | Bert Blyleven | | 483 | 475 | 8 |
| 1973-08-10 | @ MIL | 113 | L 1-5 | 56-57 | 3 | 21,331 | Bill Campbell | Skip Lockwood | Bill Champion | Bill Campbell | | 484 | 480 | 4 |
| 1973-08-11 | @ MIL | 114 | L 6-7 | 56-58 | 3 | 17,866 | Joe Decker | Jerry Bell | Eduardo Rodriguez | Eddie Bane | | 490 | 487 | 3 |
| 1973-08-12 | @ MIL | 115 | L 9-10 | 56-59 | 3 | 17,961 | Jim Kaat | Jim Colborn | Eduardo Rodriguez | Bill Hands | | 499 | 497 | 2 |
| 1973-08-13 | vs DET | 116 | L 3-9 | 56-60 | 4 | 17,633 | Bert Blyleven | Woodie Fryman | Woodie Fryman | Bert Blyleven | John Hiller | 502 | 506 | -4 |
| 1973-08-14 | vs DET | 117 | W 12-1 | 57-60 | 3 | 15,214 | Dave Goltz | Joe Coleman | Dave Goltz | Joe Coleman | | 514 | 507 | 7 |
| 1973-08-15 | vs DET | 118 | W 9-7 | 58-60 | 3 | 17,214 | Joe Decker | Mickey Lolich | Bill Campbell | Bob Miller | | 523 | 514 | 9 |
| 1973-08-17 | @ CLE | 119 | W 14-2 | 59-60 | 3 | 8,051 | Bert Blyleven | Dick Bosman | Bert Blyleven | Dick Bosman | | 537 | 516 | 21 |
| 1973-08-18 | @ CLE | 120 | L 0-5 | 59-61 | 3 | 6,694 | Dick Woodson | Gaylord Perry | Gaylord Perry | Dick Woodson | | 537 | 521 | 16 |
| 1973-08-19 | @ CLE | 121 | L 3-5 | 59-63 | 3 | 0 | Dave Goltz | Tom Timmermann | Tom Timmermann | Dave Goltz | Ken Sanders | 540 | 526 | 14 |
| 1973-08-19 | @ CLE | 122 | L 3-4 | 59-63 | 3 | 13,146 | Joe Decker | Jerry Johnson | Ken Sanders | Eddie Bane | | 543 | 530 | 13 |
| 1973-08-20 | @ BAL | 123 | L 3-4 | 59-64 | 3 | 8,134 | Ray Corbin | Doyle Alexander | Doyle Alexander | Bill Hands | | 546 | 534 | 12 |
| 1973-08-21 | @ BAL | 124 | L 1-2 | 59-65 | 3 | 8,829 | Bert Blyleven | Jim Palmer | Grant Jackson | Bert Blyleven | | 547 | 536 | 11 |
| 1973-08-22 | @ BAL | 125 | L 3-4 | 59-66 | 3 | 12,063 | Bill Campbell | Mike Cuellar | Mike Cuellar | Danny Fife | Bob Reynolds | 550 | 540 | 10 |
| 1973-08-24 | vs MIL | 126 | W 3-0 | 60-66 | 3 | 15,012 | Joe Decker | Skip Lockwood | Joe Decker | Skip Lockwood | | 553 | 540 | 13 |
| 1973-08-25 | vs MIL | 127 | L 6-10 | 60-67 | 3 | 12,955 | Dave Goltz | Jim Colborn | Jim Colborn | Dave Goltz | Carlos Velazquez | 559 | 550 | 9 |
| 1973-08-26 | vs MIL | 128 | L 2-3 | 60-68 | 4 | 13,013 | Bert Blyleven | Jim Slaton | Jim Slaton | Bert Blyleven | Carlos Velazquez | 561 | 553 | 8 |
| 1973-08-27 | @ DET | 129 | W 5-3 | 61-68 | 4 | 30,212 | Danny Fife | Mike Strahler | Danny Fife | Mike Strahler | Bill Campbell | 566 | 556 | 10 |
| 1973-08-28 | @ DET | 130 | W 5-0 | 62-68 | 4 | 18,325 | Joe Decker | Mickey Lolich | Joe Decker | Mickey Lolich | | 571 | 556 | 15 |
| 1973-08-29 | @ DET | 131 | L 5-9 | 62-69 | 5 | 16,227 | Dave Goltz | Jim Perry | John Hiller | Dave Goltz | | 576 | 565 | 11 |
| 1973-08-30 | @ TEX | 132 | W 5-2 | 63-69 | 3 | 4,012 | Bert Blyleven | Jim Bibby | Bert Blyleven | Jim Bibby | Bill Campbell | 581 | 567 | 14 |
| 1973-08-31 | @ TEX | 133 | W 11-2 | 64-69 | 3 | 4,445 | Danny Fife | Jim Merritt | Danny Fife | Jim Merritt | Ray Corbin | 592 | 569 | 23 |
| 1973-09-01 | @ TEX | 134 | W 10-7 | 65-69 | 3 | 7,798 | Eddie Bane | David Clyde | Bill Hands | Jackie Brown | | 602 | 576 | 26 |
| 1973-09-02 | @ TEX | 135 | L 0-2 | 65-70 | 4 | 3,242 | Joe Decker | Charlie Hudson | Charlie Hudson | Joe Decker | | 602 | 578 | 24 |
| 1973-09-03 | @ KCA | 136 | W 11-5 | 66-70 | 4 | 11,134 | Dave Goltz | Dick Drago | Bill Campbell | Gene Garber | | 613 | 583 | 30 |
| 1973-09-04 | @ KCA | 137 | W 6-0 | 67-70 | 4 | 9,741 | Bert Blyleven | Paul Splittorff | Bert Blyleven | Paul Splittorff | | 619 | 583 | 36 |
| 1973-09-06 | vs CHA | 138 | L 0-6 | 67-71 | 4 | 5,798 | Danny Fife | Stan Bahnsen | Stan Bahnsen | Danny Fife | | 619 | 589 | 30 |
| 1973-09-07 | vs CHA | 139 | L 2-5 | 67-72 | 4 | 7,328 | Joe Decker | Wilbur Wood | Wilbur Wood | Joe Decker | Cy Acosta | 621 | 594 | 27 |
| 1973-09-08 | vs CHA | 140 | W 6-2 | 68-72 | 4 | 8,902 | Dave Goltz | Terry Forster | Dave Goltz | Terry Forster | Bill Campbell | 627 | 596 | 31 |
| 1973-09-09 | vs CHA | 141 | L 7-10 | 68-73 | 4 | 10,422 | Bert Blyleven | Jim Kaat | Jim Kaat | Bert Blyleven | Cy Acosta | 634 | 606 | 28 |
| 1973-09-10 | vs TEX | 142 | W 5-4 | 69-73 | 4 | 5,063 | Danny Fife | Charlie Hudson | Ray Corbin | Bill Gogolewski | | 639 | 610 | 29 |
| 1973-09-11 | vs TEX | 143 | W 6-3 | 70-73 | 4 | 3,912 | Joe Decker | Sonny Siebert | Joe Decker | Sonny Siebert | Bill Hands | 645 | 613 | 32 |
| 1973-09-12 | vs TEX | 144 | L 2-5 | 70-74 | 4 | 4,597 | Eddie Bane | David Clyde | Rick Henninger | Eddie Bane | | 647 | 618 | 29 |
| 1973-09-14 | @ CHA | 145 | W 6-0 | 71-74 | 4 | 11,698 | Bert Blyleven | Stan Bahnsen | Bert Blyleven | Stan Bahnsen | | 653 | 618 | 35 |
| 1973-09-15 | @ CHA | 146 | L 4-11 | 71-75 | 4 | 7,298 | Joe Decker | Wilbur Wood | Wilbur Wood | Joe Decker | Cy Acosta | 657 | 629 | 28 |
| 1973-09-16 | @ CHA | 147 | W 6-1 | 72-75 | 4 | 7,128 | Dave Goltz | Terry Forster | Dave Goltz | Terry Forster | Bill Campbell | 663 | 630 | 33 |
| 1973-09-17 | @ KCA | 148 | W 8-3 | 73-75 | 3 | 8,571 | Ray Corbin | Steve Busby | Ray Corbin | Steve Busby | Bill Campbell | 671 | 633 | 38 |
| 1973-09-18 | @ KCA | 149 | L 3-4 | 73-76 | 3 | 9,350 | Bert Blyleven | Al Fitzmorris | Al Fitzmorris | Bert Blyleven | Steve Mingori | 674 | 637 | 37 |
| 1973-09-19 | vs OAK | 150 | L 0-3 | 73-77 | 4 | 5,202 | Joe Decker | Vida Blue | Vida Blue | Joe Decker | | 674 | 640 | 34 |
| 1973-09-20 | vs OAK | 151 | W 4-3 | 75-77 | 3 | 0 | Bill Hands | Blue Moon Odom | Bill Campbell | Blue Moon Odom | | 678 | 643 | 35 |
| 1973-09-20 | vs OAK | 152 | W 5-4 | 75-77 | 3 | 5,388 | Danny Fife | Darold Knowles | Vic Albury | Rollie Fingers | | 683 | 647 | 36 |
| 1973-09-21 | vs OAK | 153 | W 8-3 | 76-77 | 3 | 3,000 | Ray Corbin | Ken Holtzman | Ray Corbin | Ken Holtzman | | 691 | 650 | 41 |
| 1973-09-22 | vs CAL | 154 | W 6-3 | 77-77 | 3 | 6,665 | Bert Blyleven | Rudy May | Bert Blyleven | Rudy May | | 697 | 653 | 44 |
| 1973-09-23 | vs CAL | 155 | L 7-15 | 77-78 | 3 | 5,426 | Joe Decker | Nolan Ryan | Nolan Ryan | Joe Decker | | 704 | 668 | 36 |
| 1973-09-24 | @ OAK | 156 | W 7-6 | 78-78 | 3 | 18,556 | Danny Fife | Blue Moon Odom | Bill Hands | Rollie Fingers | Bill Campbell | 711 | 674 | 37 |
| 1973-09-25 | @ OAK | 157 | W 9-4 | 79-78 | 3 | 3,713 | Ray Corbin | Chuck Dobson | Ray Corbin | Chuck Dobson | Bill Campbell | 720 | 678 | 42 |
| 1973-09-26 | @ OAK | 158 | W 4-1 | 80-78 | 3 | 3,521 | Bert Blyleven | Catfish Hunter | Bert Blyleven | Catfish Hunter | | 724 | 679 | 45 |
| 1973-09-27 | @ CAL | 159 | L 4-5 | 80-79 | 3 | 9,100 | Dave Goltz | Nolan Ryan | Nolan Ryan | Bill Campbell | | 728 | 684 | 44 |
| 1973-09-28 | @ CAL | 160 | W 7-1 | 81-79 | 3 | 5,430 | Danny Fife | Rudy May | Danny Fife | Rudy May | | 735 | 685 | 50 |
| 1973-09-29 | @ CAL | 161 | L 3-4 | 81-80 | 3 | 14,783 | Ray Corbin | Bill Singer | Bill Singer | Bill Campbell | | 738 | 689 | 49 |
| 1973-09-30 | @ CAL | 162 | L 0-3 | 81-81 | 3 | 7,489 | Bert Blyleven | Frank Tanana | Frank Tanana | Bert Blyleven | | 738 | 692 | 46 |