| 1973-04-06 | @ SDN | 1 | L 2-4 | 0-1 | 6 | 32,019 | Don Sutton | Clay Kirby | Clay Kirby | Don Sutton | Vicente Romo | 2 | 4 | -2 |
| 1973-04-07 | @ SDN | 2 | L 3-4 | 0-2 | 6 | 16,803 | Andy Messersmith | Fred Norman | Vicente Romo | Jim Brewer | | 5 | 8 | -3 |
| 1973-04-08 | @ SDN | 3 | W 4-0 | 1-2 | 6 | 10,695 | Tommy John | Steve Arlin | Tommy John | Steve Arlin | George Culver | 9 | 8 | 1 |
| 1973-04-09 | @ HOU | 4 | L 1-4 | 1-3 | 6 | 28,399 | Claude Osteen | Jerry Reuss | Jerry Reuss | Charlie Hough | | 10 | 12 | -2 |
| 1973-04-10 | @ HOU | 5 | L 3-4 | 1-4 | 6 | 15,738 | Al Downing | Dave Roberts | Jim Crawford | George Culver | | 13 | 16 | -3 |
| 1973-04-11 | vs CIN | 6 | L 1-4 | 1-5 | 6 | 24,755 | Don Sutton | Don Gullett | Don Gullett | Don Sutton | Tom Hall | 14 | 20 | -6 |
| 1973-04-12 | vs CIN | 7 | L 2-5 | 1-6 | 6 | 14,056 | Andy Messersmith | Jack Billingham | Jack Billingham | Andy Messersmith | | 16 | 25 | -9 |
| 1973-04-13 | vs ATL | 8 | W 6-3 | 2-6 | 6 | 27,133 | Tommy John | Ron Reed | Tommy John | Ron Reed | Jim Brewer | 22 | 28 | -6 |
| 1973-04-14 | vs ATL | 9 | W 2-1 | 3-6 | 5 | 18,354 | Claude Osteen | Carl Morton | Claude Osteen | Carl Morton | | 24 | 29 | -5 |
| 1973-04-15 | vs ATL | 10 | W 6-2 | 4-6 | 5 | 18,276 | Al Downing | Gary Gentry | Al Downing | Gary Gentry | | 30 | 31 | -1 |
| 1973-04-16 | vs HOU | 11 | W 2-1 | 5-6 | 3 | 13,344 | Don Sutton | Ken Forsch | George Culver | Jim York | | 32 | 32 | 0 |
| 1973-04-17 | vs HOU | 12 | W 7-2 | 6-6 | 3 | 7,976 | Andy Messersmith | Don Wilson | Andy Messersmith | Don Wilson | | 39 | 34 | 5 |
| 1973-04-18 | vs HOU | 13 | L 2-7 | 6-7 | 3 | 13,733 | Tommy John | Jerry Reuss | Jerry Reuss | Tommy John | | 41 | 41 | 0 |
| 1973-04-19 | vs SFN | 14 | L 6-8 | 6-8 | 4 | 25,858 | Claude Osteen | Jim Willoughby | Jim Willoughby | Claude Osteen | Randy Moffitt | 47 | 49 | -2 |
| 1973-04-20 | vs SFN | 15 | L 3-7 | 6-9 | 4 | 27,437 | Al Downing | Juan Marichal | Juan Marichal | Al Downing | | 50 | 56 | -6 |
| 1973-04-21 | vs SFN | 16 | W 1-0 | 7-9 | 4 | 24,540 | Don Sutton | Ron Bryant | Don Sutton | Ron Bryant | | 51 | 56 | -5 |
| 1973-04-22 | vs SFN | 17 | L 2-4 | 7-10 | 4 | 20,317 | Andy Messersmith | Jim Barr | Jim Barr | Andy Messersmith | Randy Moffitt | 53 | 60 | -7 |
| 1973-04-24 | @ SLN | 18 | L 0-2 | 7-11 | 4 | 7,938 | Claude Osteen | Rick Wise | Rick Wise | Claude Osteen | | 53 | 62 | -9 |
| 1973-04-25 | @ SLN | 19 | W 5-3 | 8-11 | 4 | 7,588 | Al Downing | Scipio Spinks | Jim Brewer | Alan Foster | | 58 | 65 | -7 |
| 1973-04-28 | @ PIT | 20 | W 3-2 | 9-11 | 4 | 9,643 | Don Sutton | Nelson Briles | Don Sutton | Nelson Briles | | 61 | 67 | -6 |
| 1973-04-29 | @ PIT | 21 | W 9-8 | 11-11 | 4 | 0 | Andy Messersmith | Steve Blass | Al Downing | Ramon Hernandez | | 70 | 75 | -5 |
| 1973-04-29 | @ PIT | 22 | W 2-1 | 11-11 | 4 | 18,083 | Claude Osteen | Dock Ellis | Claude Osteen | Dock Ellis | | 72 | 76 | -4 |
| 1973-05-01 | vs CHN | 23 | L 5-9 | 11-12 | 4 | 12,413 | Tommy John | Burt Hooton | Burt Hooton | Tommy John | Dave LaRoche | 77 | 85 | -8 |
| 1973-05-02 | vs CHN | 24 | W 4-1 | 12-12 | 4 | 13,120 | Don Sutton | Milt Pappas | Don Sutton | Milt Pappas | | 81 | 86 | -5 |
| 1973-05-03 | vs CHN | 25 | L 1-4 | 12-13 | 4 | 12,853 | Andy Messersmith | Rick Reuschel | Dave LaRoche | Andy Messersmith | Jack Aker | 82 | 90 | -8 |
| 1973-05-04 | vs SLN | 26 | W 6-5 | 13-13 | 4 | 34,187 | Claude Osteen | Rick Wise | Jim Brewer | Diego Segui | | 88 | 95 | -7 |
| 1973-05-05 | vs SLN | 27 | W 11-3 | 14-13 | 4 | 17,462 | Tommy John | Jim Bibby | Tommy John | Jim Bibby | | 99 | 98 | 1 |
| 1973-05-06 | vs SLN | 28 | W 3-0 | 15-13 | 4 | 17,355 | Al Downing | Alan Foster | Al Downing | Alan Foster | | 102 | 98 | 4 |
| 1973-05-07 | vs PIT | 29 | L 4-5 | 15-14 | 4 | 17,745 | Don Sutton | Luke Walker | Bob Johnson | Don Sutton | Jim Rooker | 106 | 103 | 3 |
| 1973-05-08 | vs PIT | 30 | W 7-4 | 16-14 | 4 | 13,620 | Andy Messersmith | Nelson Briles | Andy Messersmith | Nelson Briles | Jim Brewer | 113 | 107 | 6 |
| 1973-05-09 | vs PIT | 31 | W 8-5 | 17-14 | 4 | 17,509 | Claude Osteen | Steve Blass | Claude Osteen | Steve Blass | George Culver | 121 | 112 | 9 |
| 1973-05-11 | @ SFN | 32 | W 3-2 | 18-14 | 4 | 21,234 | Al Downing | Juan Marichal | Al Downing | Juan Marichal | Jim Brewer | 124 | 114 | 10 |
| 1973-05-12 | @ SFN | 33 | L 4-5 | 18-15 | 4 | 14,758 | Don Sutton | Jim Willoughby | Ron Bryant | George Culver | | 128 | 119 | 9 |
| 1973-05-13 | @ SFN | 34 | W 15-3 | 19-15 | 4 | 31,626 | Andy Messersmith | Jim Barr | Andy Messersmith | Jim Barr | | 143 | 122 | 21 |
| 1973-05-15 | @ CIN | 35 | L 1-4 | 19-16 | 4 | 11,731 | Claude Osteen | Don Gullett | Don Gullett | Claude Osteen | Pedro Borbon | 144 | 126 | 18 |
| 1973-05-16 | @ CIN | 36 | W 8-6 | 20-16 | 4 | 10,120 | Al Downing | Ross Grimsley | Charlie Hough | Tom Hall | | 152 | 132 | 20 |
| 1973-05-17 | @ CIN | 37 | W 3-1 | 21-16 | 4 | 11,433 | Don Sutton | Clay Carroll | Don Sutton | Pedro Borbon | Pete Richert | 155 | 133 | 22 |
| 1973-05-18 | @ ATL | 38 | W 3-2 | 22-16 | 4 | 10,181 | Andy Messersmith | Ron Reed | Andy Messersmith | Roric Harrison | Jim Brewer | 158 | 135 | 23 |
| 1973-05-19 | @ ATL | 39 | L 7-7 | 22-17 | 4 | 7,046 | Tommy John | Carl Morton | | | | 165 | 142 | 23 |
| 1973-05-20 | @ ATL | 40 | L 2-3 | 23-18 | 4 | 0 | Claude Osteen | Phil Niekro | Phil Niekro | George Culver | | 167 | 145 | 22 |
| 1973-05-20 | @ ATL | 41 | W 8-3 | 23-18 | 4 | 21,570 | Al Downing | Gary Gentry | Al Downing | Gary Gentry | | 175 | 148 | 27 |
| 1973-05-22 | vs SDN | 42 | W 5-1 | 24-18 | 4 | 13,562 | Don Sutton | Bill Greif | Don Sutton | Bill Greif | | 180 | 149 | 31 |
| 1973-05-23 | vs SDN | 43 | L 3-4 | 24-19 | 4 | 11,975 | Andy Messersmith | Mike Corkins | Steve Arlin | Andy Messersmith | Vicente Romo | 183 | 153 | 30 |
| 1973-05-24 | vs NYN | 44 | L 3-7 | 24-20 | 4 | 27,580 | Tommy John | Tom Seaver | George Stone | Doug Rau | Jim McAndrew | 186 | 160 | 26 |
| 1973-05-25 | vs NYN | 45 | W 6-4 | 25-20 | 4 | 53,624 | Claude Osteen | Jon Matlack | Claude Osteen | Jon Matlack | Pete Richert | 192 | 164 | 28 |
| 1973-05-26 | vs NYN | 46 | W 9-5 | 26-20 | 4 | 28,635 | Al Downing | Harry Parker | George Culver | Jim McAndrew | Pete Richert | 201 | 169 | 32 |
| 1973-05-27 | vs NYN | 47 | W 2-1 | 27-20 | 3 | 31,108 | Don Sutton | Jerry Koosman | Don Sutton | Jerry Koosman | | 203 | 170 | 33 |
| 1973-05-28 | vs PHI | 48 | W 5-1 | 28-20 | 3 | 15,300 | Andy Messersmith | Dick Ruthven | Andy Messersmith | Dick Ruthven | | 208 | 171 | 37 |
| 1973-05-29 | vs PHI | 49 | W 9-3 | 29-20 | 2 | 12,350 | Tommy John | Ken Brett | Tommy John | Ken Brett | Jim Brewer | 217 | 174 | 43 |
| 1973-05-30 | vs PHI | 50 | W 9-4 | 30-20 | 2 | 15,462 | Claude Osteen | Steve Carlton | Claude Osteen | Steve Carlton | | 226 | 178 | 48 |
| 1973-06-01 | vs MON | 51 | W 3-2 | 31-20 | 2 | 22,480 | Don Sutton | Balor Moore | Don Sutton | Balor Moore | | 229 | 180 | 49 |
| 1973-06-02 | vs MON | 52 | L 3-6 | 31-21 | 2 | 25,908 | Andy Messersmith | Steve Renko | Steve Renko | Andy Messersmith | Mike Marshall | 232 | 186 | 46 |
| 1973-06-03 | vs MON | 53 | L 1-4 | 31-22 | 2 | 34,785 | Al Downing | Ernie McAnally | Ernie McAnally | Al Downing | | 233 | 190 | 43 |
| 1973-06-05 | @ CHN | 54 | W 10-1 | 32-22 | 2 | 12,068 | Claude Osteen | Fergie Jenkins | Claude Osteen | Fergie Jenkins | Pete Richert | 243 | 191 | 52 |
| 1973-06-06 | @ CHN | 55 | L 4-6 | 32-23 | 2 | 14,050 | Don Sutton | Burt Hooton | Burt Hooton | Don Sutton | Jack Aker | 247 | 197 | 50 |
| 1973-06-07 | @ CHN | 56 | W 4-0 | 33-23 | 2 | 12,025 | Andy Messersmith | Rick Reuschel | Andy Messersmith | Rick Reuschel | | 251 | 197 | 54 |
| 1973-06-08 | @ NYN | 57 | W 5-3 | 34-23 | 2 | 42,500 | Tommy John | Tom Seaver | Tommy John | Tom Seaver | Pete Richert | 256 | 200 | 56 |
| 1973-06-09 | @ NYN | 58 | L 2-4 | 34-24 | 2 | 47,800 | Al Downing | Jon Matlack | Jon Matlack | Al Downing | | 258 | 204 | 54 |
| 1973-06-10 | @ NYN | 59 | W 4-0 | 35-24 | 2 | 41,139 | Claude Osteen | Jerry Koosman | Claude Osteen | Jerry Koosman | | 262 | 204 | 58 |
| 1973-06-11 | @ PHI | 60 | W 5-3 | 36-24 | 2 | 10,635 | Don Sutton | Dick Ruthven | Don Sutton | Dick Ruthven | Pete Richert | 267 | 207 | 60 |
| 1973-06-12 | @ PHI | 61 | W 8-6 | 37-24 | 2 | 16,218 | Andy Messersmith | Steve Carlton | Doug Rau | Mac Scarce | Jim Brewer | 275 | 213 | 62 |
| 1973-06-13 | @ PHI | 62 | L 3-16 | 37-25 | 2 | 13,068 | Tommy John | Ken Brett | Ken Brett | Tommy John | | 278 | 229 | 49 |
| 1973-06-15 | @ MON | 63 | L 3-4 | 37-26 | 2 | 15,493 | Al Downing | Ernie McAnally | Ernie McAnally | George Culver | Mike Marshall | 281 | 233 | 48 |
| 1973-06-16 | @ MON | 64 | W 6-3 | 38-26 | 2 | 10,187 | Claude Osteen | Bill Stoneman | Claude Osteen | Bill Stoneman | | 287 | 236 | 51 |
| 1973-06-17 | @ MON | 65 | W 3-2 | 39-26 | 1 | 25,664 | Don Sutton | Mike Torrez | Jim Brewer | Mike Marshall | | 290 | 238 | 52 |
| 1973-06-18 | vs ATL | 66 | W 13-3 | 40-26 | 1 | 24,544 | Andy Messersmith | Ron Reed | Andy Messersmith | Ron Reed | | 303 | 241 | 62 |
| 1973-06-19 | vs ATL | 67 | W 3-0 | 41-26 | 1 | 34,785 | Tommy John | Phil Niekro | Tommy John | Phil Niekro | Pete Richert | 306 | 241 | 65 |
| 1973-06-20 | vs ATL | 68 | W 6-5 | 42-26 | 1 | 24,184 | Al Downing | Roric Harrison | Jim Brewer | Ron Schueler | | 312 | 246 | 66 |
| 1973-06-21 | vs ATL | 69 | W 5-0 | 43-26 | 1 | 20,384 | Claude Osteen | Carl Morton | Claude Osteen | Carl Morton | | 317 | 246 | 71 |
| 1973-06-22 | vs CIN | 70 | W 3-2 | 44-26 | 1 | 37,224 | Don Sutton | Ross Grimsley | Pete Richert | Clay Carroll | | 320 | 248 | 72 |
| 1973-06-23 | vs CIN | 71 | L 1-4 | 45-27 | 1 | 0 | Andy Messersmith | Fred Norman | Fred Norman | Andy Messersmith | | 321 | 252 | 69 |
| 1973-06-23 | vs CIN | 72 | W 5-1 | 45-27 | 1 | 52,831 | Tommy John | Tom Hall | Tommy John | Tom Hall | | 326 | 253 | 73 |
| 1973-06-24 | vs CIN | 73 | W 5-2 | 46-27 | 1 | 36,903 | Al Downing | Don Gullett | Al Downing | Don Gullett | | 331 | 255 | 76 |
| 1973-06-25 | @ SDN | 74 | W 3-2 | 47-27 | 1 | 6,916 | Claude Osteen | Bill Greif | Claude Osteen | Bill Greif | Jim Brewer | 334 | 257 | 77 |
| 1973-06-26 | @ SDN | 75 | W 7-0 | 48-27 | 1 | 10,408 | Don Sutton | Randy Jones | Don Sutton | Randy Jones | | 341 | 257 | 84 |
| 1973-06-28 | @ ATL | 76 | L 2-3 | 49-28 | 1 | 0 | Andy Messersmith | Phil Niekro | Jim Panther | Pete Richert | Danny Frisella | 343 | 260 | 83 |
| 1973-06-28 | @ ATL | 77 | W 8-3 | 49-28 | 1 | 11,500 | Tommy John | Ron Reed | Tommy John | Ron Reed | Charlie Hough | 351 | 263 | 88 |
| 1973-06-29 | @ ATL | 78 | W 12-9 | 50-28 | 1 | 9,987 | Al Downing | Carl Morton | George Culver | Jim Panther | Doug Rau | 363 | 272 | 91 |
| 1973-06-30 | @ CIN | 79 | W 8-7 | 51-28 | 1 | 30,580 | Claude Osteen | Tom Hall | George Culver | Ed Sprague | | 371 | 279 | 92 |
| 1973-07-01 | @ CIN | 80 | L 3-4 | 51-30 | 1 | 0 | Don Sutton | Fred Norman | Fred Norman | Don Sutton | | 374 | 283 | 91 |
| 1973-07-01 | @ CIN | 81 | L 2-3 | 51-30 | 1 | 46,047 | Doug Rau | Ross Grimsley | Pedro Borbon | Charlie Hough | | 376 | 286 | 90 |
| 1973-07-02 | @ CIN | 82 | L 2-4 | 51-31 | 1 | 16,516 | Andy Messersmith | Jim McGlothlin | Don Gullett | Jim Brewer | | 378 | 290 | 88 |
| 1973-07-03 | vs SDN | 83 | L 1-4 | 51-32 | 1 | 18,551 | Tommy John | Randy Jones | Randy Jones | Tommy John | | 379 | 294 | 85 |
| 1973-07-04 | vs SDN | 84 | L 2-4 | 51-33 | 1 | 46,681 | Al Downing | Rich Troedson | Rich Troedson | Al Downing | Mike Caldwell | 381 | 298 | 83 |
| 1973-07-05 | vs SDN | 85 | L 0-3 | 51-34 | 1 | 18,397 | Claude Osteen | Steve Arlin | Steve Arlin | Claude Osteen | | 381 | 301 | 80 |
| 1973-07-06 | vs PIT | 86 | W 3-2 | 52-34 | 1 | 28,011 | Don Sutton | Luke Walker | Don Sutton | Luke Walker | | 384 | 303 | 81 |
| 1973-07-07 | vs PIT | 87 | W 8-6 | 53-34 | 1 | 33,197 | Andy Messersmith | Jim Rooker | Doug Rau | John Lamb | Jim Brewer | 392 | 309 | 83 |
| 1973-07-08 | vs PIT | 88 | W 3-2 | 54-34 | 1 | 24,144 | Tommy John | Dock Ellis | Pete Richert | Dave Giusti | | 395 | 311 | 84 |
| 1973-07-10 | vs SLN | 89 | L 4-5 | 54-35 | 1 | 25,820 | Claude Osteen | Tom Murphy | Tom Murphy | Claude Osteen | Wayne Granger | 399 | 316 | 83 |
| 1973-07-11 | vs SLN | 90 | W 3-1 | 55-35 | 1 | 24,539 | Don Sutton | Bob Gibson | Don Sutton | Bob Gibson | | 402 | 317 | 85 |
| 1973-07-12 | vs SLN | 91 | W 4-0 | 56-35 | 1 | 20,378 | Andy Messersmith | Rich Folkers | Andy Messersmith | Rich Folkers | | 406 | 317 | 89 |
| 1973-07-13 | vs CHN | 92 | W 5-0 | 57-35 | 1 | 49,058 | Tommy John | Fergie Jenkins | Tommy John | Fergie Jenkins | | 411 | 317 | 94 |
| 1973-07-14 | vs CHN | 93 | W 7-3 | 58-35 | 1 | 53,870 | Al Downing | Burt Hooton | Al Downing | Burt Hooton | Jim Brewer | 418 | 320 | 98 |
| 1973-07-15 | vs CHN | 94 | W 9-3 | 59-35 | 1 | 42,975 | Claude Osteen | Rick Reuschel | Claude Osteen | Rick Reuschel | | 427 | 323 | 104 |
| 1973-07-16 | @ PIT | 95 | W 1-0 | 60-35 | 1 | 16,570 | Don Sutton | Nelson Briles | Don Sutton | Nelson Briles | | 428 | 323 | 105 |
| 1973-07-17 | @ PIT | 96 | W 8-4 | 61-35 | 1 | 17,389 | Andy Messersmith | Luke Walker | Andy Messersmith | Luke Walker | Jim Brewer | 436 | 327 | 109 |
| 1973-07-18 | @ PIT | 97 | L 2-3 | 61-36 | 1 | 24,248 | Tommy John | Dock Ellis | Dock Ellis | Tommy John | Dave Giusti | 438 | 330 | 108 |
| 1973-07-19 | @ SLN | 98 | W 3-2 | 62-36 | 1 | 19,026 | Al Downing | Alan Foster | Al Downing | Alan Foster | Jim Brewer | 441 | 332 | 109 |
| 1973-07-20 | @ SLN | 99 | W 4-3 | 63-36 | 1 | 24,434 | Claude Osteen | Tom Murphy | Doug Rau | Wayne Granger | | 445 | 335 | 110 |
| 1973-07-21 | @ SLN | 100 | L 1-8 | 63-37 | 1 | 39,340 | Don Sutton | Bob Gibson | Bob Gibson | Don Sutton | | 446 | 343 | 103 |
| 1973-07-22 | @ SLN | 101 | L 4-5 | 63-38 | 1 | 41,879 | Andy Messersmith | Reggie Cleveland | Diego Segui | Jim Brewer | Al Hrabosky | 450 | 348 | 102 |
| 1973-07-26 | vs HOU | 102 | W 3-1 | 64-38 | 1 | 23,145 | Tommy John | Dave Roberts | Tommy John | Dave Roberts | Jim Brewer | 453 | 349 | 104 |
| 1973-07-27 | vs HOU | 103 | L 2-5 | 64-39 | 1 | 19,818 | Al Downing | J.R. Richard | Juan Pizarro | Al Downing | | 455 | 354 | 101 |
| 1973-07-28 | vs SFN | 104 | L 0-5 | 64-40 | 1 | 55,185 | Don Sutton | Jim Barr | Jim Barr | Don Sutton | | 455 | 359 | 96 |
| 1973-07-29 | vs SFN | 105 | W 6-2 | 65-40 | 1 | 41,109 | Andy Messersmith | Tom Bradley | Andy Messersmith | Tom Bradley | | 461 | 361 | 100 |
| 1973-07-30 | vs SFN | 106 | W 5-2 | 66-40 | 1 | 49,945 | Claude Osteen | Ron Bryant | Claude Osteen | Ron Bryant | | 466 | 363 | 103 |
| 1973-07-31 | @ HOU | 107 | L 2-3 | 66-41 | 1 | 19,247 | Tommy John | Dave Roberts | Dave Roberts | Tommy John | Don Wilson | 468 | 366 | 102 |
| 1973-08-01 | @ HOU | 108 | L 0-5 | 66-42 | 1 | 19,956 | Al Downing | J.R. Richard | J.R. Richard | Al Downing | | 468 | 371 | 97 |
| 1973-08-02 | @ HOU | 109 | W 4-2 | 67-42 | 1 | 19,770 | Don Sutton | Jerry Reuss | Don Sutton | Juan Pizarro | Jim Brewer | 472 | 373 | 99 |
| 1973-08-03 | @ SFN | 110 | W 3-0 | 68-42 | 1 | 25,680 | Andy Messersmith | Tom Bradley | Andy Messersmith | Tom Bradley | | 475 | 373 | 102 |
| 1973-08-04 | @ SFN | 111 | L 2-3 | 68-43 | 1 | 25,949 | Claude Osteen | Ron Bryant | Elias Sosa | Jim Brewer | | 477 | 376 | 101 |
| 1973-08-05 | @ SFN | 112 | W 4-3 | 69-43 | 1 | 33,122 | Tommy John | Juan Marichal | Tommy John | Juan Marichal | Jim Brewer | 481 | 379 | 102 |
| 1973-08-06 | @ SDN | 113 | W 2-0 | 70-43 | 1 | 8,050 | Al Downing | Clay Kirby | Al Downing | Clay Kirby | | 483 | 379 | 104 |
| 1973-08-07 | @ SDN | 114 | W 6-1 | 71-43 | 1 | 12,186 | Don Sutton | Rich Troedson | Don Sutton | Rich Troedson | Jim Brewer | 489 | 380 | 109 |
| 1973-08-08 | vs NYN | 115 | L 0-1 | 71-44 | 1 | 24,219 | Andy Messersmith | Jon Matlack | Jon Matlack | Andy Messersmith | | 489 | 381 | 108 |
| 1973-08-09 | vs NYN | 116 | W 1-0 | 72-44 | 1 | 24,737 | Claude Osteen | Jerry Koosman | Claude Osteen | Jerry Koosman | | 490 | 381 | 109 |
| 1973-08-10 | vs PHI | 117 | L 3-5 | 72-45 | 1 | 21,167 | Tommy John | Wayne Twitchell | Wayne Twitchell | Tommy John | | 493 | 386 | 107 |
| 1973-08-11 | vs PHI | 118 | L 1-3 | 72-46 | 1 | 50,557 | Al Downing | Ken Brett | Ken Brett | Al Downing | | 494 | 389 | 105 |
| 1973-08-12 | vs PHI | 119 | W 2-1 | 73-46 | 1 | 22,281 | Andy Messersmith | Steve Carlton | Jim Brewer | Steve Carlton | | 496 | 390 | 106 |
| 1973-08-13 | vs MON | 120 | W 8-5 | 74-46 | 1 | 21,437 | Claude Osteen | Mike Torrez | Claude Osteen | Pat Jarvis | Jim Brewer | 504 | 395 | 109 |
| 1973-08-14 | vs MON | 121 | W 4-3 | 75-46 | 1 | 23,448 | Tommy John | Balor Moore | Doug Rau | Balor Moore | | 508 | 398 | 110 |
| 1973-08-15 | vs MON | 122 | W 7-2 | 76-46 | 1 | 25,982 | Don Sutton | Ernie McAnally | Don Sutton | Ernie McAnally | Jim Brewer | 515 | 400 | 115 |
| 1973-08-17 | @ CHN | 123 | L 1-5 | 76-47 | 1 | 13,987 | Andy Messersmith | Bill Bonham | Bill Bonham | Andy Messersmith | Bob Locker | 516 | 405 | 111 |
| 1973-08-18 | @ CHN | 124 | L 1-2 | 76-48 | 1 | 24,893 | Claude Osteen | Burt Hooton | Burt Hooton | Claude Osteen | | 517 | 407 | 110 |
| 1973-08-19 | @ CHN | 125 | W 2-1 | 77-48 | 1 | 25,266 | Tommy John | Rick Reuschel | Jim Brewer | Rick Reuschel | | 519 | 408 | 111 |
| 1973-08-21 | @ NYN | 126 | L 1-2 | 77-49 | 1 | 26,351 | Don Sutton | Ray Sadecki | Ray Sadecki | Don Sutton | | 520 | 410 | 110 |
| 1973-08-22 | @ NYN | 127 | L 3-4 | 77-50 | 1 | 25,442 | Andy Messersmith | George Stone | Tug McGraw | Jim Brewer | | 523 | 414 | 109 |
| 1973-08-23 | @ NYN | 128 | W 5-4 | 78-50 | 1 | 26,056 | Claude Osteen | Jon Matlack | Claude Osteen | Buzz Capra | | 528 | 418 | 110 |
| 1973-08-24 | @ PHI | 129 | W 3-0 | 79-50 | 1 | 30,671 | Tommy John | Wayne Twitchell | Tommy John | Wayne Twitchell | | 531 | 418 | 113 |
| 1973-08-25 | @ PHI | 130 | W 6-4 | 80-50 | 1 | 44,116 | Al Downing | Ken Brett | Pete Richert | Mac Scarce | Doug Rau | 537 | 422 | 115 |
| 1973-08-26 | @ PHI | 131 | W 7-3 | 81-50 | 1 | 31,045 | Don Sutton | Steve Carlton | Don Sutton | Steve Carlton | Charlie Hough | 544 | 425 | 119 |
| 1973-08-27 | @ MON | 132 | L 0-4 | 81-51 | 1 | 20,098 | Andy Messersmith | Steve Rogers | Steve Rogers | Andy Messersmith | | 544 | 429 | 115 |
| 1973-08-28 | @ MON | 133 | W 6-1 | 82-51 | 1 | 19,131 | Claude Osteen | Balor Moore | Claude Osteen | Balor Moore | | 550 | 430 | 120 |
| 1973-08-29 | @ MON | 134 | L 5-6 | 82-52 | 1 | 14,178 | Tommy John | Mike Torrez | Tom Walker | Jim Brewer | | 555 | 436 | 119 |
| 1973-08-30 | vs HOU | 135 | W 6-5 | 83-52 | 1 | 25,242 | Al Downing | Don Wilson | Charlie Hough | Jim Ray | Jim Brewer | 561 | 441 | 120 |
| 1973-08-31 | vs HOU | 136 | L 2-3 | 83-53 | 1 | 31,395 | Doug Rau | Tom Griffin | Tom Griffin | Jim Brewer | | 563 | 444 | 119 |
| 1973-09-01 | vs HOU | 137 | L 0-2 | 83-54 | 1 | 32,178 | Andy Messersmith | Jerry Reuss | Jerry Reuss | Andy Messersmith | | 563 | 446 | 117 |
| 1973-09-02 | vs HOU | 138 | L 0-9 | 83-55 | 1 | 25,022 | Claude Osteen | Dave Roberts | Dave Roberts | Claude Osteen | | 563 | 455 | 108 |
| 1973-09-03 | @ SFN | 139 | L 8-11 | 83-56 | 2 | 15,279 | Tommy John | Tom Bradley | Don McMahon | Pete Richert | | 571 | 466 | 105 |
| 1973-09-04 | @ SFN | 140 | L 1-3 | 83-57 | 2 | 15,470 | Al Downing | Ron Bryant | Ron Bryant | Al Downing | Elias Sosa | 572 | 469 | 103 |
| 1973-09-05 | @ SFN | 141 | L 0-7 | 83-58 | 2 | 16,341 | Doug Rau | Jim Barr | Jim Barr | Doug Rau | | 572 | 476 | 96 |
| 1973-09-06 | vs SDN | 142 | L 2-3 | 83-59 | 2 | 18,235 | Don Sutton | Randy Jones | Randy Jones | Don Sutton | Mike Corkins | 574 | 479 | 95 |
| 1973-09-07 | vs SDN | 143 | L 3-4 | 83-60 | 2 | 15,931 | Claude Osteen | Steve Arlin | Steve Arlin | Claude Osteen | Mike Caldwell | 577 | 483 | 94 |
| 1973-09-08 | vs SDN | 144 | L 6-9 | 83-61 | 2 | 29,860 | Tommy John | Clay Kirby | Gary Ross | Pete Richert | Frank Snook | 583 | 492 | 91 |
| 1973-09-09 | vs SDN | 145 | W 5-3 | 84-61 | 2 | 20,565 | Andy Messersmith | Rich Troedson | Andy Messersmith | Rich Troedson | | 588 | 495 | 93 |
| 1973-09-11 | @ CIN | 146 | L 3-6 | 84-62 | 2 | 46,415 | Don Sutton | Ross Grimsley | Clay Carroll | Jim Brewer | Dick Baney | 591 | 501 | 90 |
| 1973-09-12 | @ CIN | 147 | L 3-7 | 84-63 | 2 | 39,038 | Claude Osteen | Jack Billingham | Jack Billingham | Claude Osteen | | 594 | 508 | 86 |
| 1973-09-13 | @ HOU | 148 | W 8-6 | 85-63 | 2 | 7,374 | Tommy John | Dave Roberts | Tommy John | Dave Roberts | Charlie Hough | 602 | 514 | 88 |
| 1973-09-14 | @ HOU | 149 | W 13-1 | 86-63 | 2 | 8,458 | Andy Messersmith | Jerry Reuss | Andy Messersmith | Jerry Reuss | | 615 | 515 | 100 |
| 1973-09-15 | @ HOU | 150 | L 1-5 | 86-64 | 2 | 6,922 | Al Downing | Tom Griffin | Tom Griffin | Al Downing | | 616 | 520 | 96 |
| 1973-09-16 | @ HOU | 151 | L 2-6 | 86-65 | 2 | 10,502 | Claude Osteen | Don Wilson | Don Wilson | Claude Osteen | | 618 | 526 | 92 |
| 1973-09-17 | vs SFN | 152 | W 7-2 | 87-65 | 2 | 23,614 | Don Sutton | Jim Barr | Don Sutton | Jim Barr | | 625 | 528 | 97 |
| 1973-09-18 | vs SFN | 153 | W 3-1 | 88-65 | 2 | 25,491 | Tommy John | Juan Marichal | Tommy John | Juan Marichal | Charlie Hough | 628 | 529 | 99 |
| 1973-09-19 | vs ATL | 154 | W 4-1 | 89-65 | 2 | 31,012 | Andy Messersmith | Phil Niekro | Andy Messersmith | Phil Niekro | Jim Brewer | 632 | 530 | 102 |
| 1973-09-20 | vs ATL | 155 | W 5-3 | 90-65 | 2 | 27,931 | Al Downing | Ron Schueler | Charlie Hough | Roric Harrison | | 637 | 533 | 104 |
| 1973-09-21 | vs CIN | 156 | L 1-4 | 90-66 | 2 | 46,308 | Claude Osteen | Jack Billingham | Tom Hall | Claude Osteen | Pedro Borbon | 638 | 537 | 101 |
| 1973-09-22 | vs CIN | 157 | L 9-11 | 90-67 | 2 | 32,343 | Don Sutton | Don Gullett | Pedro Borbon | Don Sutton | Clay Carroll | 647 | 548 | 99 |
| 1973-09-23 | vs CIN | 158 | W 6-4 | 91-67 | 2 | 50,007 | Tommy John | Fred Norman | Tommy John | Fred Norman | Jim Brewer | 653 | 552 | 101 |
| 1973-09-25 | @ ATL | 159 | W 5-1 | 92-67 | 2 | 10,211 | Don Sutton | Phil Niekro | Don Sutton | Phil Niekro | | 658 | 553 | 105 |
| 1973-09-26 | @ ATL | 160 | W 9-8 | 93-67 | 2 | 5,571 | Al Downing | Ron Schueler | Charlie Hough | Roric Harrison | Doug Rau | 667 | 561 | 106 |
| 1973-09-28 | @ SDN | 161 | W 5-2 | 94-67 | 2 | 9,169 | Tommy John | Mike Corkins | Tommy John | Mike Corkins | Charlie Hough | 672 | 563 | 109 |
| 1973-09-29 | @ SDN | 162 | W 3-2 | 95-67 | 2 | 14,846 | Geoff Zahn | Clay Kirby | Geoff Zahn | Clay Kirby | Greg Shanahan | 675 | 565 | 110 |