| 1973-04-07 | @ CLE | 1 | L 1-2 | 0-1 | 4 | 74,420 | Mickey Lolich | Gaylord Perry | Gaylord Perry | Mickey Lolich | | 1 | 2 | -1 |
| 1973-04-08 | @ CLE | 2 | W 4-0 | 1-1 | 4 | 10,798 | Joe Coleman | Dick Tidrow | Joe Coleman | Dick Tidrow | Lerrin LaGrow | 5 | 2 | 3 |
| 1973-04-11 | vs BAL | 3 | L 1-3 | 1-2 | 4 | 46,389 | Woodie Fryman | Jim Palmer | Eddie Watt | Lerrin LaGrow | | 6 | 5 | 1 |
| 1973-04-12 | vs BAL | 4 | L 0-1 | 1-3 | 5 | 6,303 | Mickey Lolich | Dave McNally | Dave McNally | Mickey Lolich | Orlando Pena | 6 | 6 | 0 |
| 1973-04-13 | vs CLE | 5 | W 4-3 | 2-3 | 3 | 5,009 | Joe Coleman | Brent Strom | Joe Coleman | Ed Farmer | | 10 | 9 | 1 |
| 1973-04-14 | vs CLE | 6 | W 8-2 | 3-3 | 3 | 11,908 | Jim Perry | Steve Dunning | Jim Perry | Steve Dunning | | 18 | 11 | 7 |
| 1973-04-15 | vs CLE | 7 | L 0-7 | 3-4 | 3 | 16,726 | Tom Timmermann | Gaylord Perry | Gaylord Perry | Tom Timmermann | | 18 | 18 | 0 |
| 1973-04-16 | @ BOS | 8 | W 9-7 | 4-4 | 3 | 29,006 | Mickey Lolich | Marty Pattin | Mickey Lolich | Marty Pattin | Lerrin LaGrow | 27 | 25 | 2 |
| 1973-04-17 | @ BOS | 9 | W 6-3 | 5-4 | 3 | 11,298 | Joe Coleman | Lynn McGlothen | Joe Coleman | Lynn McGlothen | John Hiller | 33 | 28 | 5 |
| 1973-04-18 | @ BOS | 10 | W 7-1 | 6-4 | 2 | 15,971 | Jim Perry | Luis Tiant | Jim Perry | Luis Tiant | | 40 | 29 | 11 |
| 1973-04-19 | @ BOS | 11 | W 11-7 | 7-4 | 2 | 13,572 | Woodie Fryman | John Curtis | Woodie Fryman | John Curtis | Tom Timmermann | 51 | 36 | 15 |
| 1973-04-20 | @ BAL | 12 | L 5-6 | 7-5 | 2 | 14,626 | Mickey Lolich | Doyle Alexander | Bob Reynolds | Lerrin LaGrow | | 56 | 42 | 14 |
| 1973-04-21 | @ BAL | 13 | W 3-1 | 8-5 | 2 | 15,448 | Joe Coleman | Dave McNally | Joe Coleman | Dave McNally | | 59 | 43 | 16 |
| 1973-04-22 | @ BAL | 14 | L 3-5 | 8-6 | 2 | 12,883 | Jim Perry | Mike Cuellar | Mike Cuellar | Jim Perry | | 62 | 48 | 14 |
| 1973-04-24 | @ TEX | 15 | L 1-2 | 8-7 | 3 | 7,119 | Mickey Lolich | Mike Paul | Mike Paul | Mickey Lolich | Steve Foucault | 63 | 50 | 13 |
| 1973-04-25 | @ TEX | 16 | L 1-4 | 8-8 | 2 | 7,386 | Joe Coleman | Rich Hand | Rich Hand | Joe Coleman | Steve Foucault | 64 | 54 | 10 |
| 1973-04-26 | @ TEX | 17 | W 3-2 | 9-8 | 3 | 5,399 | Woodie Fryman | Pete Broberg | Woodie Fryman | Pete Broberg | John Hiller | 67 | 56 | 11 |
| 1973-04-27 | vs KCA | 18 | L 0-3 | 9-9 | 2 | 16,345 | Jim Perry | Steve Busby | Steve Busby | Jim Perry | | 67 | 59 | 8 |
| 1973-04-28 | vs KCA | 19 | L 4-7 | 9-10 | 3 | 12,231 | Mickey Lolich | Paul Splittorff | Gene Garber | John Hiller | | 71 | 66 | 5 |
| 1973-04-29 | vs KCA | 20 | W 6-1 | 10-10 | 2 | 16,245 | Joe Coleman | Wayne Simpson | Joe Coleman | Wayne Simpson | | 77 | 67 | 10 |
| 1973-05-01 | vs CAL | 21 | L 2-6 | 10-11 | 4 | 10,118 | Woodie Fryman | Bill Singer | Bill Singer | Woodie Fryman | | 79 | 73 | 6 |
| 1973-05-02 | vs CAL | 22 | L 3-5 | 10-12 | 5 | 10,003 | Mickey Lolich | Nolan Ryan | Nolan Ryan | Lerrin LaGrow | | 82 | 78 | 4 |
| 1973-05-04 | vs TEX | 23 | W 5-1 | 11-12 | 1 | 9,639 | Jim Perry | Dick Bosman | Jim Perry | Dick Bosman | John Hiller | 87 | 79 | 8 |
| 1973-05-05 | vs TEX | 24 | W 2-0 | 12-12 | 1 | 11,033 | Joe Coleman | Mike Paul | Joe Coleman | Mike Paul | John Hiller | 89 | 79 | 10 |
| 1973-05-06 | vs TEX | 25 | L 2-7 | 12-13 | 1 | 14,600 | Mickey Lolich | Rich Hand | Rich Hand | Mickey Lolich | | 91 | 86 | 5 |
| 1973-05-08 | @ KCA | 26 | L 2-7 | 12-14 | 2 | 13,065 | Woodie Fryman | Paul Splittorff | Paul Splittorff | Woodie Fryman | | 93 | 93 | 0 |
| 1973-05-09 | @ KCA | 27 | W 4-1 | 13-14 | 1 | 15,680 | Jim Perry | Steve Busby | Jim Perry | Steve Busby | John Hiller | 97 | 94 | 3 |
| 1973-05-10 | @ KCA | 28 | L 2-8 | 13-15 | 2 | 11,412 | Joe Coleman | Dick Drago | Dick Drago | Joe Coleman | | 99 | 102 | -3 |
| 1973-05-11 | vs MIL | 29 | W 6-5 | 14-15 | 1 | 12,415 | Mickey Lolich | Jerry Bell | Mickey Lolich | Jerry Bell | | 105 | 107 | -2 |
| 1973-05-12 | vs MIL | 30 | L 2-6 | 14-16 | 2 | 12,640 | Woodie Fryman | Jim Slaton | Jim Slaton | Woodie Fryman | | 107 | 113 | -6 |
| 1973-05-13 | vs MIL | 31 | L 5-6 | 14-17 | 5 | 23,810 | Jim Perry | Jim Colborn | Chris Short | John Hiller | Frank Linzy | 112 | 119 | -7 |
| 1973-05-14 | @ NYA | 32 | W 8-0 | 15-17 | 3 | 8,643 | Joe Coleman | Fritz Peterson | Joe Coleman | Fritz Peterson | | 120 | 119 | 1 |
| 1973-05-16 | vs BOS | 33 | W 6-5 | 16-17 | 1 | 10,030 | Mickey Lolich | Luis Tiant | John Hiller | Luis Tiant | | 126 | 124 | 2 |
| 1973-05-17 | vs BOS | 34 | W 1-0 | 17-17 | 1 | 9,236 | Jim Perry | John Curtis | Jim Perry | John Curtis | | 127 | 124 | 3 |
| 1973-05-18 | vs BOS | 35 | W 5-4 | 18-17 | 1 | 21,845 | Woodie Fryman | Marty Pattin | Tom Timmermann | Marty Pattin | John Hiller | 132 | 128 | 4 |
| 1973-05-19 | @ MIL | 36 | W 4-2 | 19-17 | 1 | 11,609 | Joe Coleman | Jerry Bell | Joe Coleman | Jerry Bell | | 136 | 130 | 6 |
| 1973-05-20 | @ MIL | 37 | L 0-1 | 20-18 | 1 | 0 | Mickey Lolich | Bill Parsons | Frank Linzy | Mickey Lolich | | 136 | 131 | 5 |
| 1973-05-20 | @ MIL | 38 | W 5-3 | 20-18 | 1 | 41,655 | Jim Perry | Gary Ryerson | Jim Perry | Gary Ryerson | John Hiller | 141 | 134 | 7 |
| 1973-05-22 | vs NYA | 39 | L 2-7 | 20-19 | 1 | 9,222 | Woodie Fryman | Mel Stottlemyre | Mel Stottlemyre | Woodie Fryman | | 143 | 141 | 2 |
| 1973-05-23 | vs NYA | 40 | L 5-6 | 20-20 | 1 | 12,038 | Joe Coleman | Fritz Peterson | Sparky Lyle | Joe Coleman | | 148 | 147 | 1 |
| 1973-05-24 | vs NYA | 41 | W 4-0 | 21-20 | 1 | 12,391 | Mickey Lolich | Doc Medich | Mickey Lolich | Doc Medich | | 152 | 147 | 5 |
| 1973-05-25 | vs OAK | 42 | W 1-0 | 22-20 | 1 | 24,011 | Jim Perry | Catfish Hunter | John Hiller | Rollie Fingers | | 153 | 147 | 6 |
| 1973-05-26 | vs OAK | 43 | W 8-5 | 23-20 | 1 | 21,179 | Woodie Fryman | Ken Holtzman | Chuck Seelbach | Horacio Pina | John Hiller | 161 | 152 | 9 |
| 1973-05-28 | vs OAK | 44 | W 4-3 | 24-20 | 1 | 21,354 | Joe Coleman | Blue Moon Odom | Joe Coleman | Blue Moon Odom | John Hiller | 165 | 155 | 10 |
| 1973-05-30 | @ CHA | 45 | W 8-3 | 25-20 | 1 | 14,777 | Mickey Lolich | Stan Bahnsen | Mickey Lolich | Stan Bahnsen | | 173 | 158 | 15 |
| 1973-05-31 | @ CHA | 46 | L 2-10 | 25-21 | 1 | 12,800 | Jim Perry | Eddie Fisher | Eddie Fisher | Jim Perry | | 175 | 168 | 7 |
| 1973-06-01 | @ MIN | 47 | W 8-3 | 26-21 | 1 | 19,950 | Joe Coleman | Jim Kaat | Joe Coleman | Jim Kaat | John Hiller | 183 | 171 | 12 |
| 1973-06-02 | @ MIN | 48 | L 2-3 | 26-22 | 1 | 13,998 | Woodie Fryman | Bert Blyleven | Ken Sanders | Woodie Fryman | | 185 | 174 | 11 |
| 1973-06-03 | @ MIN | 49 | W 8-2 | 27-22 | 1 | 35,815 | Mickey Lolich | Bill Hands | Mickey Lolich | Bill Hands | | 193 | 176 | 17 |
| 1973-06-05 | @ CAL | 50 | W 5-2 | 28-22 | 1 | 9,777 | Jim Perry | Rich Hand | Jim Perry | Rich Hand | John Hiller | 198 | 178 | 20 |
| 1973-06-06 | @ CAL | 51 | L 4-7 | 28-23 | 1 | 11,691 | Joe Coleman | Bill Singer | Bill Singer | Joe Coleman | Dave Sells | 202 | 185 | 17 |
| 1973-06-07 | @ CAL | 52 | L 0-3 | 28-24 | 1 | 13,807 | Woodie Fryman | Nolan Ryan | Nolan Ryan | Woodie Fryman | | 202 | 188 | 14 |
| 1973-06-08 | @ OAK | 53 | W 4-1 | 29-24 | 1 | 13,135 | Mickey Lolich | Vida Blue | Mickey Lolich | Vida Blue | | 206 | 189 | 17 |
| 1973-06-09 | @ OAK | 54 | L 0-4 | 29-25 | 2 | 18,779 | Jim Perry | Ken Holtzman | Ken Holtzman | Jim Perry | | 206 | 193 | 13 |
| 1973-06-10 | @ OAK | 55 | L 0-5 | 29-26 | 2 | 11,782 | Joe Coleman | Catfish Hunter | Catfish Hunter | Joe Coleman | | 206 | 198 | 8 |
| 1973-06-12 | vs CHA | 56 | W 6-5 | 30-26 | 1 | 30,302 | Woodie Fryman | Wilbur Wood | John Hiller | Wilbur Wood | | 212 | 203 | 9 |
| 1973-06-13 | vs CHA | 57 | L 2-10 | 30-27 | 2 | 26,437 | Mickey Lolich | Stan Bahnsen | Stan Bahnsen | Mickey Lolich | | 214 | 213 | 1 |
| 1973-06-15 | vs MIN | 58 | L 6-13 | 30-28 | 4 | 34,926 | Jim Perry | Dick Woodson | Jim Kaat | Jim Perry | | 220 | 226 | -6 |
| 1973-06-16 | vs MIN | 59 | L 0-5 | 30-29 | 4 | 23,428 | Joe Coleman | Bert Blyleven | Bert Blyleven | Joe Coleman | | 220 | 231 | -11 |
| 1973-06-17 | vs MIN | 60 | W 6-0 | 31-29 | 4 | 52,622 | Mickey Lolich | Joe Decker | Mickey Lolich | Joe Decker | | 226 | 231 | -5 |
| 1973-06-18 | @ CLE | 61 | W 5-1 | 32-29 | 3 | 20,011 | Jim Perry | Brent Strom | Jim Perry | Brent Strom | | 231 | 232 | -1 |
| 1973-06-19 | @ CLE | 62 | L 7-8 | 32-30 | 4 | 3,485 | Woodie Fryman | Dick Tidrow | Jerry Johnson | Fred Scherman | | 238 | 240 | -2 |
| 1973-06-20 | @ CLE | 63 | L 6-7 | 32-31 | 4 | 4,637 | Joe Coleman | Dick Bosman | Tom Timmermann | Mike Strahler | | 244 | 247 | -3 |
| 1973-06-21 | @ NYA | 64 | L 1-5 | 32-32 | 4 | 14,940 | Mickey Lolich | Pat Dobson | Pat Dobson | Mickey Lolich | | 245 | 252 | -7 |
| 1973-06-22 | @ NYA | 65 | L 4-5 | 32-33 | 4 | 19,501 | Jim Perry | Fritz Peterson | Lindy McDaniel | Fred Scherman | | 249 | 257 | -8 |
| 1973-06-23 | @ NYA | 66 | L 2-3 | 32-34 | 5 | 21,797 | Woodie Fryman | Sam McDowell | Sam McDowell | Woodie Fryman | Lindy McDaniel | 251 | 260 | -9 |
| 1973-06-24 | @ NYA | 67 | L 2-3 | 32-36 | 5 | 0 | Joe Coleman | Steve Kline | Fred Beene | Joe Coleman | Sparky Lyle | 253 | 263 | -10 |
| 1973-06-24 | @ NYA | 68 | L 1-2 | 32-36 | 5 | 62,107 | Mickey Lolich | Doc Medich | Lindy McDaniel | Mickey Lolich | | 254 | 265 | -11 |
| 1973-06-25 | @ BOS | 69 | L 1-2 | 32-37 | 5 | 20,837 | Jim Perry | Bill Lee | Bill Lee | Jim Perry | | 255 | 267 | -12 |
| 1973-06-26 | @ BOS | 70 | W 4-1 | 33-37 | 5 | 20,152 | Mike Strahler | Luis Tiant | Mike Strahler | Luis Tiant | John Hiller | 259 | 268 | -9 |
| 1973-06-27 | vs MIL | 71 | W 6-3 | 35-37 | 5 | 0 | Joe Coleman | Jim Slaton | Joe Coleman | Frank Linzy | John Hiller | 265 | 271 | -6 |
| 1973-06-27 | vs MIL | 72 | W 5-4 | 35-37 | 5 | 30,661 | Woodie Fryman | Eduardo Rodriguez | Ed Farmer | Skip Lockwood | John Hiller | 270 | 275 | -5 |
| 1973-06-28 | vs MIL | 73 | W 8-6 | 36-37 | 5 | 15,155 | Mickey Lolich | Chris Short | Bob Miller | Rob Gardner | John Hiller | 278 | 281 | -3 |
| 1973-06-29 | vs BAL | 74 | L 2-9 | 36-38 | 5 | 35,247 | Jim Perry | Doyle Alexander | Doyle Alexander | Jim Perry | | 280 | 290 | -10 |
| 1973-06-30 | vs BAL | 75 | W 4-1 | 37-38 | 5 | 27,085 | Mike Strahler | Mike Cuellar | Mike Strahler | Mike Cuellar | John Hiller | 284 | 291 | -7 |
| 1973-07-01 | vs BAL | 76 | W 5-3 | 39-38 | 4 | 0 | Joe Coleman | Jim Palmer | Joe Coleman | Jim Palmer | John Hiller | 289 | 294 | -5 |
| 1973-07-01 | vs BAL | 77 | W 1-0 | 39-38 | 4 | 48,273 | Mickey Lolich | Dave McNally | Mickey Lolich | Dave McNally | | 290 | 294 | -4 |
| 1973-07-02 | @ CLE | 78 | W 4-3 | 40-38 | 4 | 4,989 | Woodie Fryman | Dick Tidrow | Ed Farmer | Dick Tidrow | John Hiller | 294 | 297 | -3 |
| 1973-07-03 | @ CLE | 79 | W 5-4 | 41-38 | 3 | 9,064 | Jim Perry | Gaylord Perry | Ed Farmer | Gaylord Perry | John Hiller | 299 | 301 | -2 |
| 1973-07-04 | vs CLE | 80 | L 2-5 | 41-39 | 4 | 26,012 | Mike Strahler | Milt Wilcox | Milt Wilcox | Mike Strahler | Tom Hilgendorf | 301 | 306 | -5 |
| 1973-07-05 | vs CLE | 81 | W 7-5 | 42-39 | 4 | 17,891 | Mickey Lolich | Brent Strom | Bob Miller | Tom Timmermann | | 308 | 311 | -3 |
| 1973-07-06 | @ KCA | 82 | L 1-12 | 42-40 | 4 | 17,313 | Joe Coleman | Steve Busby | Steve Busby | Joe Coleman | | 309 | 323 | -14 |
| 1973-07-07 | @ KCA | 83 | L 2-5 | 42-41 | 4 | 25,178 | Jim Perry | Ken Wright | Ken Wright | Jim Perry | | 311 | 328 | -17 |
| 1973-07-08 | @ KCA | 84 | W 3-0 | 43-41 | 4 | 24,912 | Mike Strahler | Dick Drago | Mike Strahler | Dick Drago | John Hiller | 314 | 328 | -14 |
| 1973-07-09 | vs TEX | 85 | L 7-9 | 43-42 | 4 | 21,933 | Mickey Lolich | Steve Dunning | Bill Gogolewski | Bob Miller | | 321 | 337 | -16 |
| 1973-07-10 | vs TEX | 86 | W 5-4 | 44-42 | 4 | 15,534 | Joe Coleman | Jim Merritt | Joe Coleman | Jim Merritt | John Hiller | 326 | 341 | -15 |
| 1973-07-11 | vs TEX | 87 | W 14-2 | 45-42 | 4 | 13,326 | Jim Perry | Lloyd Allen | Jim Perry | Lloyd Allen | Ed Farmer | 340 | 343 | -3 |
| 1973-07-12 | vs CAL | 88 | W 7-6 | 46-42 | 4 | 15,513 | Mike Strahler | Bill Singer | John Hiller | Dave Sells | | 347 | 349 | -2 |
| 1973-07-13 | vs CAL | 89 | W 8-2 | 47-42 | 4 | 26,646 | Mickey Lolich | Clyde Wright | Mickey Lolich | Clyde Wright | | 355 | 351 | 4 |
| 1973-07-14 | vs CAL | 90 | W 2-1 | 48-42 | 4 | 28,253 | Joe Coleman | Rudy May | Joe Coleman | Rudy May | | 357 | 352 | 5 |
| 1973-07-15 | vs CAL | 91 | L 0-6 | 48-43 | 4 | 41,411 | Jim Perry | Nolan Ryan | Nolan Ryan | Jim Perry | | 357 | 358 | -1 |
| 1973-07-16 | vs KCA | 92 | L 2-10 | 48-44 | 4 | 27,360 | Mike Strahler | Dick Drago | Dick Drago | Mike Strahler | | 359 | 368 | -9 |
| 1973-07-17 | vs KCA | 93 | L 3-4 | 48-45 | 4 | 19,903 | Mickey Lolich | Al Fitzmorris | Al Fitzmorris | Mickey Lolich | Doug Bird | 362 | 372 | -10 |
| 1973-07-18 | vs KCA | 94 | W 14-4 | 49-45 | 4 | 19,256 | Joe Coleman | Steve Busby | Joe Coleman | Steve Busby | | 376 | 376 | 0 |
| 1973-07-20 | @ TEX | 95 | L 6-8 | 49-46 | 4 | 8,770 | Jim Perry | Jim Merritt | Bill Gogolewski | Jim Perry | Mike Paul | 382 | 384 | -2 |
| 1973-07-21 | @ TEX | 96 | L 3-4 | 49-47 | 4 | 21,643 | Mickey Lolich | David Clyde | Jackie Brown | Mickey Lolich | | 385 | 388 | -3 |
| 1973-07-22 | @ TEX | 97 | L 3-4 | 49-48 | 4 | 7,187 | Joe Coleman | Jim Bibby | Jackie Brown | John Hiller | | 388 | 392 | -4 |
| 1973-07-26 | vs BOS | 98 | W 6-5 | 50-48 | 4 | 22,364 | Mickey Lolich | Luis Tiant | John Hiller | Bobby Bolin | | 394 | 397 | -3 |
| 1973-07-27 | vs BOS | 99 | W 4-2 | 51-48 | 4 | 31,828 | Jim Perry | Bill Lee | John Hiller | Bill Lee | | 398 | 399 | -1 |
| 1973-07-28 | @ BAL | 100 | W 3-2 | 52-48 | 4 | 29,509 | Joe Coleman | Mike Cuellar | Joe Coleman | Mike Cuellar | Bob Miller | 401 | 401 | 0 |
| 1973-07-29 | @ BAL | 101 | W 8-3 | 53-48 | 4 | 16,504 | Mike Strahler | Don Hood | Mike Strahler | Don Hood | | 409 | 404 | 5 |
| 1973-07-30 | @ BAL | 102 | W 4-3 | 54-48 | 4 | 15,584 | Mickey Lolich | Jesse Jefferson | Mickey Lolich | Jesse Jefferson | John Hiller | 413 | 407 | 6 |
| 1973-07-31 | @ MIL | 103 | W 6-5 | 56-48 | 3 | 0 | Jim Perry | Jim Colborn | Bob Miller | Jim Colborn | John Hiller | 419 | 412 | 7 |
| 1973-07-31 | @ MIL | 104 | W 9-4 | 56-48 | 3 | 27,315 | Woodie Fryman | Jim Slaton | Woodie Fryman | Jim Slaton | Ed Farmer | 428 | 416 | 12 |
| 1973-08-01 | @ MIL | 105 | W 2-1 | 57-48 | 3 | 12,913 | Joe Coleman | Skip Lockwood | Joe Coleman | Eduardo Rodriguez | | 430 | 417 | 13 |
| 1973-08-02 | @ MIL | 106 | L 3-6 | 57-49 | 3 | 17,008 | Mike Strahler | Jerry Bell | Jerry Bell | Mike Strahler | | 433 | 423 | 10 |
| 1973-08-03 | vs NYA | 107 | W 7-2 | 58-49 | 2 | 43,334 | Mickey Lolich | Sam McDowell | Mickey Lolich | Sam McDowell | | 440 | 425 | 15 |
| 1973-08-04 | vs NYA | 108 | L 2-3 | 58-50 | 3 | 48,120 | Woodie Fryman | Fritz Peterson | Lindy McDaniel | John Hiller | | 442 | 428 | 14 |
| 1973-08-05 | vs NYA | 109 | W 8-6 | 59-50 | 2 | 42,174 | Joe Coleman | Pat Dobson | Joe Coleman | Pat Dobson | John Hiller | 450 | 434 | 16 |
| 1973-08-06 | vs NYA | 110 | W 5-4 | 60-50 | 1 | 51,001 | Mike Strahler | Mel Stottlemyre | Bob Miller | Sparky Lyle | | 455 | 438 | 17 |
| 1973-08-07 | vs OAK | 111 | L 4-8 | 61-51 | 1 | 0 | Mickey Lolich | Vida Blue | Vida Blue | Mickey Lolich | Darold Knowles | 459 | 446 | 13 |
| 1973-08-07 | vs OAK | 112 | W 2-0 | 61-51 | 1 | 42,007 | Jim Perry | Paul Lindblad | Jim Perry | Paul Lindblad | John Hiller | 461 | 446 | 15 |
| 1973-08-08 | vs OAK | 113 | W 3-2 | 62-51 | 1 | 28,000 | Woodie Fryman | Ken Holtzman | Woodie Fryman | Ken Holtzman | John Hiller | 464 | 448 | 16 |
| 1973-08-09 | vs CHA | 114 | L 4-5 | 62-52 | 2 | 18,369 | Joe Coleman | Terry Forster | Cy Acosta | Joe Coleman | | 468 | 453 | 15 |
| 1973-08-10 | vs CHA | 115 | W 7-3 | 63-52 | 1 | 31,080 | Mike Strahler | Steve Stone | Fred Scherman | Steve Stone | | 475 | 456 | 19 |
| 1973-08-11 | vs CHA | 116 | W 4-2 | 64-52 | 1 | 41,764 | Mickey Lolich | Wilbur Wood | Mickey Lolich | Wilbur Wood | John Hiller | 479 | 458 | 21 |
| 1973-08-12 | vs CHA | 117 | W 6-2 | 65-52 | 1 | 43,211 | Jim Perry | Stan Bahnsen | Jim Perry | Stan Bahnsen | | 485 | 460 | 25 |
| 1973-08-13 | @ MIN | 118 | W 9-3 | 66-52 | 1 | 17,633 | Woodie Fryman | Bert Blyleven | Woodie Fryman | Bert Blyleven | John Hiller | 494 | 463 | 31 |
| 1973-08-14 | @ MIN | 119 | L 1-12 | 66-53 | 1 | 15,214 | Joe Coleman | Dave Goltz | Dave Goltz | Joe Coleman | | 495 | 475 | 20 |
| 1973-08-15 | @ MIN | 120 | L 7-9 | 66-54 | 2 | 17,214 | Mickey Lolich | Joe Decker | Bill Campbell | Bob Miller | | 502 | 484 | 18 |
| 1973-08-17 | @ CAL | 121 | L 2-10 | 66-55 | 2 | 16,201 | Woodie Fryman | Nolan Ryan | Nolan Ryan | Woodie Fryman | | 504 | 494 | 10 |
| 1973-08-18 | @ CAL | 122 | L 1-4 | 66-56 | 2 | 12,490 | Joe Coleman | Bill Singer | Bill Singer | Joe Coleman | | 505 | 498 | 7 |
| 1973-08-19 | @ CAL | 123 | W 4-3 | 67-56 | 2 | 10,289 | Mickey Lolich | Clyde Wright | John Hiller | Aurelio Monteagudo | | 509 | 501 | 8 |
| 1973-08-20 | @ OAK | 124 | L 2-7 | 67-57 | 2 | 41,969 | Jim Perry | Vida Blue | Vida Blue | Jim Perry | | 511 | 508 | 3 |
| 1973-08-21 | @ OAK | 125 | W 6-4 | 68-57 | 2 | 8,250 | Woodie Fryman | Ken Holtzman | John Hiller | Ken Holtzman | | 517 | 512 | 5 |
| 1973-08-22 | @ OAK | 126 | L 3-7 | 68-58 | 3 | 7,159 | Joe Coleman | Blue Moon Odom | Blue Moon Odom | Joe Coleman | Rollie Fingers | 520 | 519 | 1 |
| 1973-08-24 | @ CHA | 127 | W 6-5 | 69-58 | 3 | 28,850 | Mickey Lolich | Wilbur Wood | Fred Scherman | Cy Acosta | | 526 | 524 | 2 |
| 1973-08-25 | @ CHA | 128 | W 4-2 | 70-58 | 3 | 24,743 | Jim Perry | Stan Bahnsen | Jim Perry | Stan Bahnsen | John Hiller | 530 | 526 | 4 |
| 1973-08-26 | @ CHA | 129 | L 1-4 | 70-60 | 3 | 0 | Joe Coleman | Jim Kaat | Jim Kaat | Joe Coleman | | 531 | 530 | 1 |
| 1973-08-26 | @ CHA | 130 | L 1-3 | 70-60 | 3 | 20,828 | Woodie Fryman | Terry Forster | Terry Forster | Woodie Fryman | Cy Acosta | 532 | 533 | -1 |
| 1973-08-27 | vs MIN | 131 | L 3-5 | 70-61 | 3 | 30,212 | Mike Strahler | Danny Fife | Danny Fife | Mike Strahler | Bill Campbell | 535 | 538 | -3 |
| 1973-08-28 | vs MIN | 132 | L 0-5 | 70-62 | 3 | 18,325 | Mickey Lolich | Joe Decker | Joe Decker | Mickey Lolich | | 535 | 543 | -8 |
| 1973-08-29 | vs MIN | 133 | W 9-5 | 71-62 | 3 | 16,227 | Jim Perry | Dave Goltz | John Hiller | Dave Goltz | | 544 | 548 | -4 |
| 1973-08-30 | vs CLE | 134 | L 0-3 | 71-63 | 3 | 12,681 | Joe Coleman | Gaylord Perry | Gaylord Perry | Joe Coleman | | 544 | 551 | -7 |
| 1973-08-31 | vs CLE | 135 | L 3-6 | 71-64 | 3 | 18,442 | Mickey Lolich | Mike Kekich | Mike Kekich | Mickey Lolich | Tom Hilgendorf | 547 | 557 | -10 |
| 1973-09-01 | vs CLE | 136 | L 4-5 | 71-65 | 3 | 18,819 | Woodie Fryman | Tom Timmermann | Tom Hilgendorf | John Hiller | Ken Sanders | 551 | 562 | -11 |
| 1973-09-02 | vs CLE | 137 | W 2-1 | 72-65 | 3 | 17,265 | Jim Perry | Dick Tidrow | Jim Perry | Dick Tidrow | John Hiller | 553 | 563 | -10 |
| 1973-09-03 | vs NYA | 138 | L 3-4 | 72-66 | 3 | 20,396 | Joe Coleman | Doc Medich | Doc Medich | Joe Coleman | | 556 | 567 | -11 |
| 1973-09-04 | vs NYA | 139 | W 2-1 | 73-66 | 3 | 17,908 | Mickey Lolich | Mel Stottlemyre | Mickey Lolich | Mel Stottlemyre | John Hiller | 558 | 568 | -10 |
| 1973-09-05 | @ CLE | 140 | W 7-3 | 74-66 | 3 | 2,514 | Lerrin LaGrow | Tom Timmermann | Lerrin LaGrow | Tom Timmermann | Fred Scherman | 565 | 571 | -6 |
| 1973-09-06 | @ CLE | 141 | L 4-10 | 74-67 | 3 | 2,871 | Woodie Fryman | Dick Tidrow | Dick Tidrow | Woodie Fryman | | 569 | 581 | -12 |
| 1973-09-07 | @ BOS | 142 | L 3-11 | 74-68 | 3 | 29,147 | Jim Perry | Marty Pattin | Marty Pattin | Jim Perry | | 572 | 592 | -20 |
| 1973-09-08 | @ BOS | 143 | W 6-1 | 75-68 | 3 | 24,694 | Joe Coleman | Bill Lee | Joe Coleman | Bill Lee | John Hiller | 578 | 593 | -15 |
| 1973-09-09 | @ BOS | 144 | W 5-4 | 76-68 | 3 | 25,224 | Mickey Lolich | John Curtis | Mickey Lolich | John Curtis | John Hiller | 583 | 597 | -14 |
| 1973-09-10 | @ MIL | 145 | L 5-6 | 76-69 | 3 | 6,705 | Lerrin LaGrow | Jim Colborn | Jim Colborn | Lerrin LaGrow | | 588 | 603 | -15 |
| 1973-09-11 | @ MIL | 146 | W 4-2 | 77-69 | 3 | 6,438 | Woodie Fryman | Jim Slaton | Woodie Fryman | Jim Slaton | John Hiller | 592 | 605 | -13 |
| 1973-09-14 | vs MIL | 147 | W 2-1 | 78-69 | 3 | 12,291 | Mickey Lolich | Jim Colborn | Mickey Lolich | Jim Colborn | John Hiller | 594 | 606 | -12 |
| 1973-09-15 | vs MIL | 148 | W 4-3 | 79-69 | 3 | 15,410 | Joe Coleman | Jim Slaton | Joe Coleman | Jim Slaton | John Hiller | 598 | 609 | -11 |
| 1973-09-16 | vs MIL | 149 | L 3-5 | 79-70 | 3 | 13,043 | Woodie Fryman | Eduardo Rodriguez | Eduardo Rodriguez | Woodie Fryman | Bill Champion | 601 | 614 | -13 |
| 1973-09-18 | vs BAL | 150 | L 2-6 | 79-71 | 3 | 12,845 | Mickey Lolich | Jesse Jefferson | Jesse Jefferson | Mickey Lolich | | 603 | 620 | -17 |
| 1973-09-19 | vs BAL | 151 | W 10-1 | 80-71 | 3 | 12,339 | Joe Coleman | Dave McNally | Joe Coleman | Dave McNally | John Hiller | 613 | 621 | -8 |
| 1973-09-20 | vs BAL | 152 | L 0-9 | 80-72 | 3 | 10,529 | Woodie Fryman | Jim Palmer | Jim Palmer | Woodie Fryman | | 613 | 630 | -17 |
| 1973-09-21 | vs BOS | 153 | W 5-1 | 81-72 | 3 | 14,827 | Jim Perry | Roger Moret | Jim Perry | Roger Moret | John Hiller | 618 | 631 | -13 |
| 1973-09-22 | vs BOS | 154 | W 4-3 | 82-72 | 3 | 16,009 | Mickey Lolich | Bill Lee | Mickey Lolich | Bill Lee | Lerrin LaGrow | 622 | 634 | -12 |
| 1973-09-23 | vs BOS | 155 | W 3-0 | 83-72 | 3 | 17,324 | Joe Coleman | Luis Tiant | Joe Coleman | Luis Tiant | | 625 | 634 | -9 |
| 1973-09-24 | vs BOS | 156 | L 0-14 | 83-73 | 3 | 12,108 | Fred Holdsworth | Marty Pattin | Marty Pattin | Fred Holdsworth | | 625 | 648 | -23 |
| 1973-09-25 | @ BAL | 157 | L 3-8 | 83-74 | 3 | 8,176 | Jim Perry | Jesse Jefferson | Jesse Jefferson | Jim Perry | Grant Jackson | 628 | 656 | -28 |
| 1973-09-26 | @ BAL | 158 | L 0-4 | 83-75 | 3 | 5,380 | Mickey Lolich | Don Hood | Don Hood | Mickey Lolich | | 628 | 660 | -32 |
| 1973-09-27 | @ BAL | 159 | W 5-2 | 84-75 | 3 | 4,719 | Joe Coleman | Wayne Garland | Joe Coleman | Wayne Garland | | 633 | 662 | -29 |
| 1973-09-28 | @ NYA | 160 | L 1-4 | 84-76 | 3 | 9,313 | Woodie Fryman | Mel Stottlemyre | Mel Stottlemyre | Woodie Fryman | | 634 | 666 | -32 |
| 1973-09-29 | @ NYA | 161 | L 0-3 | 84-77 | 3 | 9,502 | Lerrin LaGrow | Doc Medich | Doc Medich | Lerrin LaGrow | | 634 | 669 | -35 |
| 1973-09-30 | @ NYA | 162 | W 8-5 | 85-77 | 3 | 32,238 | Fred Holdsworth | Fritz Peterson | John Hiller | Lindy McDaniel | | 642 | 674 | -32 |