| 1972-04-15 | @ OAK | 1 | L 3-4 | 0-1 | 5 | 9,912 | Bert Blyleven | Ken Holtzman | Bob Locker | Dave LaRoche | | 3 | 4 | -1 |
| 1972-04-16 | @ OAK | 2 | W 3-2 | 1-1 | 2 | 9,051 | Dick Woodson | Catfish Hunter | Ray Corbin | Catfish Hunter | Wayne Granger | 6 | 6 | 0 |
| 1972-04-18 | @ CAL | 3 | L 0-2 | 1-2 | 4 | 5,191 | Jim Perry | Nolan Ryan | Nolan Ryan | Jim Perry | | 6 | 8 | -2 |
| 1972-04-19 | @ CAL | 4 | W 12-3 | 2-2 | 3 | 6,451 | Bert Blyleven | Andy Messersmith | Bert Blyleven | Andy Messersmith | Dave LaRoche | 18 | 11 | 7 |
| 1972-04-23 | vs OAK | 5 | W 8-4 | 3-2 | 3 | 17,876 | Bert Blyleven | Ken Holtzman | Bert Blyleven | Ken Holtzman | | 26 | 15 | 11 |
| 1972-04-25 | vs BOS | 6 | W 12-0 | 4-2 | 3 | 4,425 | Jim Perry | Marty Pattin | Jim Perry | Marty Pattin | | 38 | 15 | 23 |
| 1972-04-26 | vs BOS | 7 | W 3-1 | 5-2 | 1 | 4,368 | Dick Woodson | Ray Culp | Dick Woodson | Ray Culp | Dave LaRoche | 41 | 16 | 25 |
| 1972-04-28 | @ NYA | 8 | W 4-1 | 6-2 | 1 | 9,149 | Bert Blyleven | Mel Stottlemyre | Bert Blyleven | Mel Stottlemyre | | 45 | 17 | 28 |
| 1972-04-29 | @ NYA | 9 | W 2-0 | 7-2 | 1 | 9,168 | Jim Kaat | Fritz Peterson | Jim Kaat | Fritz Peterson | Dave LaRoche | 47 | 17 | 30 |
| 1972-04-30 | @ NYA | 10 | L 4-5 | 8-3 | 1 | 0 | Jim Perry | Steve Kline | Sparky Lyle | Tom Norton | | 51 | 22 | 29 |
| 1972-04-30 | @ NYA | 11 | W 5-4 | 8-3 | 1 | 27,475 | Dick Woodson | Mike Kekich | Dick Woodson | Fred Beene | Dave LaRoche | 56 | 26 | 30 |
| 1972-05-03 | @ MIL | 12 | W 7-0 | 9-3 | 1 | 3,833 | Bert Blyleven | Jim Slaton | Bert Blyleven | Jim Slaton | | 63 | 26 | 37 |
| 1972-05-05 | @ BOS | 13 | W 5-2 | 10-3 | 1 | 13,208 | Jim Kaat | Ray Culp | Jim Kaat | Ray Culp | Wayne Granger | 68 | 28 | 40 |
| 1972-05-06 | @ BOS | 14 | W 3-2 | 11-3 | 1 | 13,799 | Jim Perry | Sonny Siebert | Jim Perry | Sonny Siebert | Dave LaRoche | 71 | 30 | 41 |
| 1972-05-07 | @ BOS | 15 | W 8-4 | 12-3 | 1 | 11,747 | Dick Woodson | Luis Tiant | Dick Woodson | Luis Tiant | Wayne Granger | 79 | 34 | 45 |
| 1972-05-08 | vs NYA | 16 | L 3-5 | 12-4 | 1 | 15,596 | Bert Blyleven | Mel Stottlemyre | Mel Stottlemyre | Bert Blyleven | Sparky Lyle | 82 | 39 | 43 |
| 1972-05-09 | vs NYA | 17 | W 4-2 | 13-4 | 1 | 6,446 | Jim Kaat | Fritz Peterson | Jim Kaat | Fritz Peterson | Wayne Granger | 86 | 41 | 45 |
| 1972-05-10 | vs NYA | 18 | W 2-0 | 14-4 | 1 | 8,014 | Jim Perry | Mike Kekich | Jim Perry | Mike Kekich | Wayne Granger | 88 | 41 | 47 |
| 1972-05-12 | vs MIL | 19 | L 3-4 | 14-5 | 1 | 8,628 | Dick Woodson | Bill Parsons | Jim Colborn | Bert Blyleven | Jim Lonborg | 91 | 45 | 46 |
| 1972-05-13 | vs MIL | 20 | W 5-4 | 15-5 | 1 | 7,871 | Bert Blyleven | Jim Lonborg | Dave LaRoche | Jim Slaton | | 96 | 49 | 47 |
| 1972-05-14 | vs MIL | 21 | W 4-2 | 16-5 | 1 | 7,496 | Jim Kaat | Skip Lockwood | Jim Kaat | Skip Lockwood | | 100 | 51 | 49 |
| 1972-05-15 | @ CHA | 22 | L 3-4 | 16-6 | 1 | 6,186 | Jim Perry | Wilbur Wood | Wilbur Wood | Jim Perry | Terry Forster | 103 | 55 | 48 |
| 1972-05-16 | @ CHA | 23 | L 1-2 | 16-7 | 1 | 15,510 | Dick Woodson | Stan Bahnsen | Stan Bahnsen | Dick Woodson | Terry Forster | 104 | 57 | 47 |
| 1972-05-17 | @ CHA | 24 | W 8-1 | 17-7 | 1 | 10,533 | Bert Blyleven | Tom Bradley | Bert Blyleven | Tom Bradley | Wayne Granger | 112 | 58 | 54 |
| 1972-05-19 | @ TEX | 25 | L 1-2 | 17-8 | 1 | 18,902 | Jim Kaat | Bill Gogolewski | Bill Gogolewski | Jim Kaat | | 113 | 60 | 53 |
| 1972-05-20 | @ TEX | 26 | L 1-5 | 17-9 | 1 | 12,016 | Jim Perry | Pete Broberg | Pete Broberg | Jim Perry | Mike Paul | 114 | 65 | 49 |
| 1972-05-21 | @ TEX | 27 | L 2-5 | 17-11 | 3 | 0 | Bert Blyleven | Rich Hand | Jim Panther | Bert Blyleven | Paul Lindblad | 116 | 70 | 46 |
| 1972-05-21 | @ TEX | 28 | L 1-3 | 17-11 | 3 | 13,440 | Dick Woodson | Jim Shellenback | Jim Shellenback | Dick Woodson | Horacio Pina | 117 | 73 | 44 |
| 1972-05-24 | @ KCA | 29 | W 1-0 | 18-11 | 3 | 8,381 | Jim Kaat | Dick Drago | Jim Kaat | Dick Drago | Wayne Granger | 118 | 73 | 45 |
| 1972-05-25 | vs TEX | 30 | W 6-5 | 19-11 | 2 | 8,781 | Jim Perry | Pete Broberg | Wayne Granger | Mike Paul | | 124 | 78 | 46 |
| 1972-05-26 | vs TEX | 31 | W 7-0 | 20-11 | 2 | 7,383 | Bert Blyleven | Jim Shellenback | Bert Blyleven | Jim Shellenback | | 131 | 78 | 53 |
| 1972-05-27 | vs TEX | 32 | L 2-16 | 20-12 | 3 | 9,477 | Dick Woodson | Dick Bosman | Dick Bosman | Dick Woodson | Paul Lindblad | 133 | 94 | 39 |
| 1972-05-28 | vs TEX | 33 | W 7-2 | 21-12 | 2 | 9,132 | Jim Kaat | Bill Gogolewski | Jim Kaat | Bill Gogolewski | | 140 | 96 | 44 |
| 1972-05-30 | vs KCA | 34 | W 3-2 | 22-12 | 2 | 6,164 | Jim Perry | Paul Splittorff | Jim Perry | Bruce Dal Canton | Dave LaRoche | 143 | 98 | 45 |
| 1972-05-31 | vs KCA | 35 | W 3-2 | 23-12 | 2 | 7,686 | Bert Blyleven | Jim Rooker | Bert Blyleven | Jim Rooker | Wayne Granger | 146 | 100 | 46 |
| 1972-06-01 | vs KCA | 36 | L 3-5 | 23-13 | 2 | 6,807 | Dick Woodson | Tom Murphy | Al Fitzmorris | Dave LaRoche | | 149 | 105 | 44 |
| 1972-06-02 | @ DET | 37 | L 4-5 | 23-14 | 2 | 25,094 | Jim Kaat | Mickey Lolich | Fred Scherman | Dave LaRoche | | 153 | 110 | 43 |
| 1972-06-03 | @ DET | 38 | L 3-5 | 23-15 | 2 | 14,699 | Jim Perry | Joe Niekro | Joe Niekro | Jim Perry | Chuck Seelbach | 156 | 115 | 41 |
| 1972-06-04 | @ DET | 39 | L 0-3 | 23-16 | 3 | 19,827 | Bert Blyleven | Tom Timmermann | Tom Timmermann | Bert Blyleven | | 156 | 118 | 38 |
| 1972-06-05 | @ BAL | 40 | W 3-2 | 24-16 | 2 | 5,235 | Dick Woodson | Dave McNally | Dick Woodson | Dave McNally | Wayne Granger | 159 | 120 | 39 |
| 1972-06-06 | @ BAL | 41 | W 5-4 | 25-16 | 2 | 6,203 | Jim Kaat | Jim Palmer | Ray Corbin | Mickey Scott | | 164 | 124 | 40 |
| 1972-06-07 | @ BAL | 42 | L 2-11 | 25-17 | 2 | 10,141 | Jim Perry | Pat Dobson | Pat Dobson | Jim Perry | | 166 | 135 | 31 |
| 1972-06-09 | @ CLE | 43 | L 1-7 | 25-18 | 3 | 7,703 | Bert Blyleven | Gaylord Perry | Gaylord Perry | Bert Blyleven | | 167 | 142 | 25 |
| 1972-06-10 | @ CLE | 44 | L 1-4 | 25-19 | 3 | 9,075 | Dick Woodson | Milt Wilcox | Milt Wilcox | Dick Woodson | Steve Mingori | 168 | 146 | 22 |
| 1972-06-11 | @ CLE | 45 | W 5-3 | 26-19 | 3 | 10,852 | Jim Kaat | Vince Colbert | Jim Kaat | Vince Colbert | Wayne Granger | 173 | 149 | 24 |
| 1972-06-12 | vs DET | 46 | L 1-2 | 26-20 | 3 | 17,839 | Bert Blyleven | Joe Niekro | Joe Niekro | Bert Blyleven | Fred Scherman | 174 | 151 | 23 |
| 1972-06-13 | vs DET | 47 | W 3-1 | 27-20 | 3 | 11,811 | Jim Perry | Tom Timmermann | Jim Perry | Tom Timmermann | | 177 | 152 | 25 |
| 1972-06-14 | vs DET | 48 | L 2-3 | 27-21 | 3 | 14,889 | Dick Woodson | Mickey Lolich | Mickey Lolich | Dick Woodson | | 179 | 155 | 24 |
| 1972-06-16 | vs BAL | 49 | L 0-3 | 27-22 | 3 | 16,297 | Jim Kaat | Jim Palmer | Jim Palmer | Jim Kaat | Grant Jackson | 179 | 158 | 21 |
| 1972-06-17 | vs BAL | 50 | L 1-4 | 27-23 | 3 | 17,272 | Bert Blyleven | Pat Dobson | Pat Dobson | Bert Blyleven | | 180 | 162 | 18 |
| 1972-06-18 | vs BAL | 51 | W 4-3 | 28-23 | 3 | 19,435 | Jim Perry | Mike Cuellar | Jim Perry | Mike Cuellar | Wayne Granger | 184 | 165 | 19 |
| 1972-06-20 | vs CLE | 52 | W 7-3 | 30-23 | 3 | 0 | Jim Kaat | Vince Colbert | Jim Kaat | Vince Colbert | | 191 | 168 | 23 |
| 1972-06-20 | vs CLE | 53 | W 3-1 | 30-23 | 3 | 11,378 | Dick Woodson | Ray Lamb | Dick Woodson | Ray Lamb | | 194 | 169 | 25 |
| 1972-06-21 | vs CLE | 54 | L 2-4 | 30-24 | 3 | 9,843 | Bert Blyleven | Gaylord Perry | Gaylord Perry | Bert Blyleven | | 196 | 173 | 23 |
| 1972-06-23 | @ KCA | 55 | L 0-5 | 30-25 | 3 | 9,712 | Jim Perry | Paul Splittorff | Paul Splittorff | Jim Perry | | 196 | 178 | 18 |
| 1972-06-24 | @ KCA | 56 | W 4-1 | 31-25 | 3 | 8,916 | Jim Kaat | Jim Rooker | Jim Kaat | Jim Rooker | | 200 | 179 | 21 |
| 1972-06-25 | @ KCA | 57 | W 5-3 | 32-26 | 3 | 0 | Bert Blyleven | Dick Drago | Bert Blyleven | Dick Drago | Wayne Granger | 205 | 182 | 23 |
| 1972-06-25 | @ KCA | 58 | L 3-8 | 32-26 | 3 | 14,777 | Dick Woodson | Tom Murphy | Roger Nelson | Dick Woodson | Tom Burgmeier | 208 | 190 | 18 |
| 1972-06-26 | vs CAL | 59 | W 7-4 | 33-26 | 3 | 12,803 | Ray Corbin | Don Rose | Ray Corbin | Don Rose | Wayne Granger | 215 | 194 | 21 |
| 1972-06-27 | vs CAL | 60 | L 1-3 | 33-27 | 3 | 6,815 | Jim Perry | Nolan Ryan | Nolan Ryan | Jim Perry | | 216 | 197 | 19 |
| 1972-06-28 | vs CAL | 61 | W 7-6 | 34-27 | 3 | 6,475 | Jim Kaat | Clyde Wright | Wayne Granger | Tom Dukes | Bob Gebhard | 223 | 203 | 20 |
| 1972-06-29 | vs KCA | 62 | L 3-5 | 34-29 | 3 | 0 | Bert Blyleven | Dick Drago | Dick Drago | Bert Blyleven | | 226 | 208 | 18 |
| 1972-06-29 | vs KCA | 63 | L 4-12 | 34-29 | 3 | 12,668 | Dick Woodson | Mike Hedlund | Mike Hedlund | Dick Woodson | Al Fitzmorris | 230 | 220 | 10 |
| 1972-06-30 | vs KCA | 64 | W 2-0 | 35-29 | 3 | 5,099 | Ray Corbin | Roger Nelson | Ray Corbin | Roger Nelson | | 232 | 220 | 12 |
| 1972-07-01 | @ CHA | 65 | L 1-5 | 35-30 | 3 | 8,757 | Jim Perry | Dave Lemonds | Dave Lemonds | Dave LaRoche | Cy Acosta | 233 | 225 | 8 |
| 1972-07-02 | @ CHA | 66 | W 6-4 | 36-31 | 3 | 0 | Jim Kaat | Wilbur Wood | Jim Kaat | Wilbur Wood | Dave LaRoche | 239 | 229 | 10 |
| 1972-07-02 | @ CHA | 67 | L 1-2 | 36-31 | 3 | 21,782 | Dick Woodson | Tom Bradley | Tom Bradley | Dick Woodson | Terry Forster | 240 | 231 | 9 |
| 1972-07-03 | @ BOS | 68 | L 2-8 | 36-32 | 3 | 13,460 | Bert Blyleven | Luis Tiant | Luis Tiant | Bert Blyleven | | 242 | 239 | 3 |
| 1972-07-04 | @ BOS | 69 | L 0-2 | 36-33 | 3 | 16,356 | Ray Corbin | Lynn McGlothen | Lynn McGlothen | Ray Corbin | | 242 | 241 | 1 |
| 1972-07-05 | @ BOS | 70 | L 0-2 | 36-34 | 3 | 12,641 | Jim Perry | Marty Pattin | Marty Pattin | Jim Perry | | 242 | 243 | -1 |
| 1972-07-07 | vs NYA | 71 | W 5-2 | 37-34 | 3 | 19,514 | Dick Woodson | Fritz Peterson | Wayne Granger | Fritz Peterson | | 247 | 245 | 2 |
| 1972-07-08 | vs NYA | 72 | L 0-1 | 37-35 | 3 | 14,866 | Bert Blyleven | Mel Stottlemyre | Mel Stottlemyre | Wayne Granger | Sparky Lyle | 247 | 246 | 1 |
| 1972-07-09 | vs NYA | 73 | L 6-9 | 37-36 | 3 | 19,613 | Ray Corbin | Steve Kline | Steve Kline | Ray Corbin | Sparky Lyle | 253 | 255 | -2 |
| 1972-07-10 | vs MIL | 74 | W 8-1 | 38-36 | 3 | 18,058 | Jim Perry | Earl Stephenson | Jim Perry | Earl Stephenson | Dave LaRoche | 261 | 256 | 5 |
| 1972-07-11 | vs MIL | 75 | L 4-5 | 38-37 | 3 | 9,682 | Dick Woodson | Skip Lockwood | Frank Linzy | Wayne Granger | | 265 | 261 | 4 |
| 1972-07-12 | vs MIL | 76 | W 7-1 | 39-37 | 3 | 8,874 | Bert Blyleven | Ken Brett | Bert Blyleven | Ken Brett | | 272 | 262 | 10 |
| 1972-07-13 | vs BOS | 77 | W 10-0 | 40-37 | 3 | 12,969 | Ray Corbin | Ray Culp | Ray Corbin | Ray Culp | | 282 | 262 | 20 |
| 1972-07-14 | vs BOS | 78 | W 7-6 | 41-37 | 3 | 14,917 | Jim Perry | Sonny Siebert | Jim Strickland | Luis Tiant | | 289 | 268 | 21 |
| 1972-07-15 | vs BOS | 79 | W 7-1 | 42-37 | 3 | 20,709 | Dick Woodson | Lynn McGlothen | Dick Woodson | Lynn McGlothen | | 296 | 269 | 27 |
| 1972-07-16 | vs BOS | 80 | L 1-6 | 42-38 | 3 | 18,222 | Bert Blyleven | Marty Pattin | Marty Pattin | Bert Blyleven | | 297 | 275 | 22 |
| 1972-07-18 | @ NYA | 81 | L 0-6 | 42-39 | 3 | 10,105 | Ray Corbin | Steve Kline | Steve Kline | Ray Corbin | | 297 | 281 | 16 |
| 1972-07-19 | @ NYA | 82 | L 3-13 | 42-40 | 3 | 19,029 | Jim Perry | Mike Kekich | Mike Kekich | Jim Perry | Fred Beene | 300 | 294 | 6 |
| 1972-07-20 | @ MIL | 83 | L 1-2 | 42-41 | 3 | 5,282 | Dick Woodson | Gary Ryerson | Gary Ryerson | Dick Woodson | | 301 | 296 | 5 |
| 1972-07-21 | @ MIL | 84 | L 0-2 | 42-42 | 3 | 9,258 | Bert Blyleven | Bill Parsons | Bill Parsons | Bert Blyleven | | 301 | 298 | 3 |
| 1972-07-22 | @ MIL | 85 | W 9-5 | 43-42 | 3 | 7,374 | Ray Corbin | Jim Colborn | Ray Corbin | Jim Colborn | Jim Strickland | 310 | 303 | 7 |
| 1972-07-23 | @ MIL | 86 | W 3-0 | 45-42 | 3 | 0 | Jim Perry | Jim Lonborg | Jim Perry | Jim Lonborg | Jim Strickland | 313 | 303 | 10 |
| 1972-07-23 | @ MIL | 87 | W 6-5 | 45-42 | 3 | 13,048 | Dave Goltz | Earl Stephenson | Dave Goltz | Earl Stephenson | Jim Strickland | 319 | 308 | 11 |
| 1972-07-27 | @ OAK | 88 | L 3-4 | 45-43 | 3 | 9,936 | Bert Blyleven | Vida Blue | Vida Blue | Bert Blyleven | Rollie Fingers | 322 | 312 | 10 |
| 1972-07-28 | @ OAK | 89 | W 4-3 | 46-43 | 3 | 10,141 | Dick Woodson | Ken Holtzman | Dick Woodson | Ken Holtzman | Dave LaRoche | 326 | 315 | 11 |
| 1972-07-29 | @ OAK | 90 | L 2-7 | 46-44 | 3 | 16,606 | Ray Corbin | Catfish Hunter | Catfish Hunter | Ray Corbin | | 328 | 322 | 6 |
| 1972-07-30 | vs CHA | 91 | W 1-0 | 47-44 | 3 | 15,792 | Jim Perry | Wilbur Wood | Jim Perry | Wilbur Wood | Wayne Granger | 329 | 322 | 7 |
| 1972-07-31 | vs CHA | 92 | L 1-8 | 47-45 | 3 | 13,652 | Bert Blyleven | Stan Bahnsen | Stan Bahnsen | Bert Blyleven | | 330 | 330 | 0 |
| 1972-08-01 | @ TEX | 93 | W 3-0 | 48-45 | 3 | 8,165 | Dick Woodson | Pete Broberg | Dick Woodson | Pete Broberg | | 333 | 330 | 3 |
| 1972-08-02 | @ TEX | 94 | L 1-4 | 48-46 | 3 | 6,716 | Ray Corbin | Mike Paul | Mike Paul | Ray Corbin | Horacio Pina | 334 | 334 | 0 |
| 1972-08-03 | @ TEX | 95 | W 9-1 | 49-46 | 3 | 5,033 | Jim Perry | Dick Bosman | Jim Perry | Dick Bosman | | 343 | 335 | 8 |
| 1972-08-04 | vs OAK | 96 | W 5-4 | 50-46 | 3 | 24,395 | Bert Blyleven | Blue Moon Odom | Bert Blyleven | Blue Moon Odom | Wayne Granger | 348 | 339 | 9 |
| 1972-08-05 | vs OAK | 97 | W 4-0 | 51-46 | 3 | 33,161 | Dick Woodson | Vida Blue | Dick Woodson | Vida Blue | | 352 | 339 | 13 |
| 1972-08-06 | vs OAK | 98 | L 3-6 | 52-47 | 3 | 0 | Ray Corbin | Ken Holtzman | Darold Knowles | Wayne Granger | Bob Locker | 355 | 345 | 10 |
| 1972-08-06 | vs OAK | 99 | W 5-1 | 52-47 | 3 | 33,571 | Dave Goltz | Dave Hamilton | Dave Goltz | Dave Hamilton | | 360 | 346 | 14 |
| 1972-08-07 | vs TEX | 100 | W 5-0 | 53-47 | 3 | 10,869 | Jim Perry | Mike Paul | Jim Perry | Mike Paul | | 365 | 346 | 19 |
| 1972-08-08 | vs TEX | 101 | W 6-5 | 54-47 | 3 | 13,586 | Bert Blyleven | Dick Bosman | Jim Strickland | Paul Lindblad | | 371 | 351 | 20 |
| 1972-08-09 | vs TEX | 102 | L 2-3 | 54-48 | 3 | 8,153 | Dick Woodson | Don Stanhouse | Don Stanhouse | Dick Woodson | | 373 | 354 | 19 |
| 1972-08-10 | @ CAL | 103 | L 1-3 | 54-49 | 3 | 7,865 | Ray Corbin | Rudy May | Rudy May | Ray Corbin | | 374 | 357 | 17 |
| 1972-08-11 | @ CAL | 104 | L 1-3 | 54-50 | 3 | 22,130 | Jim Perry | Clyde Wright | Clyde Wright | Jim Perry | | 375 | 360 | 15 |
| 1972-08-12 | @ CAL | 105 | W 4-1 | 55-50 | 3 | 8,935 | Dave Goltz | Andy Messersmith | Dave Goltz | Andy Messersmith | | 379 | 361 | 18 |
| 1972-08-13 | @ CAL | 106 | W 4-3 | 56-50 | 3 | 12,338 | Dick Woodson | Nolan Ryan | Dick Woodson | Nolan Ryan | | 383 | 364 | 19 |
| 1972-08-15 | @ DET | 107 | W 7-6 | 57-50 | 3 | 21,423 | Ray Corbin | Joe Coleman | Dave LaRoche | Lerrin LaGrow | | 390 | 370 | 20 |
| 1972-08-17 | @ DET | 108 | L 2-12 | 58-51 | 3 | 0 | Jim Perry | Woodie Fryman | Woodie Fryman | Jim Perry | | 392 | 382 | 10 |
| 1972-08-17 | @ DET | 109 | W 7-6 | 58-51 | 3 | 20,533 | Dave Goltz | Bill Slayback | Jim Strickland | Chuck Seelbach | | 399 | 388 | 11 |
| 1972-08-18 | @ BAL | 110 | W 3-1 | 59-51 | 3 | 12,592 | Dick Woodson | Dave McNally | Dick Woodson | Dave McNally | | 402 | 389 | 13 |
| 1972-08-19 | @ BAL | 111 | L 1-2 | 59-52 | 3 | 13,712 | Bert Blyleven | Jim Palmer | Jim Palmer | Bert Blyleven | | 403 | 391 | 12 |
| 1972-08-20 | @ BAL | 112 | W 4-1 | 60-52 | 3 | 16,027 | Ray Corbin | Mike Cuellar | Ray Corbin | Mike Cuellar | | 407 | 392 | 15 |
| 1972-08-21 | @ CLE | 113 | L 3-10 | 60-53 | 3 | 18,009 | Jim Perry | Milt Wilcox | Milt Wilcox | Jim Perry | Steve Mingori | 410 | 402 | 8 |
| 1972-08-22 | @ CLE | 114 | L 2-3 | 60-54 | 3 | 37,671 | Dave Goltz | Gaylord Perry | Gaylord Perry | Wayne Granger | | 412 | 405 | 7 |
| 1972-08-23 | @ CLE | 115 | L 1-5 | 60-55 | 3 | 12,706 | Dick Woodson | Steve Dunning | Steve Dunning | Dick Woodson | Phil Hennigan | 413 | 410 | 3 |
| 1972-08-26 | vs DET | 116 | L 3-5 | 60-56 | 3 | 36,090 | Bert Blyleven | Mickey Lolich | Bill Slayback | Jim Strickland | Lerrin LaGrow | 416 | 415 | 1 |
| 1972-08-27 | vs DET | 117 | L 3-5 | 60-58 | 3 | 0 | Dave Goltz | Woodie Fryman | Fred Scherman | Wayne Granger | | 419 | 420 | -1 |
| 1972-08-27 | vs DET | 118 | L 0-1 | 60-58 | 3 | 24,962 | Ray Corbin | Joe Coleman | Joe Coleman | Dave LaRoche | | 419 | 421 | -2 |
| 1972-08-28 | vs BAL | 119 | L 0-2 | 60-59 | 3 | 12,913 | Dick Woodson | Jim Palmer | Jim Palmer | Dick Woodson | | 419 | 423 | -4 |
| 1972-08-29 | vs BAL | 120 | L 4-9 | 60-60 | 3 | 10,563 | Jim Perry | Mike Cuellar | Mike Cuellar | Jim Perry | | 423 | 432 | -9 |
| 1972-08-30 | vs BAL | 121 | W 7-1 | 61-60 | 3 | 8,923 | Bert Blyleven | Pat Dobson | Bert Blyleven | Pat Dobson | | 430 | 433 | -3 |
| 1972-09-01 | vs CLE | 122 | W 5-4 | 62-60 | 3 | 6,175 | Dave Goltz | Milt Wilcox | Dave LaRoche | Steve Mingori | | 435 | 437 | -2 |
| 1972-09-02 | vs CLE | 123 | L 3-5 | 62-61 | 3 | 8,356 | Dick Woodson | Steve Dunning | Steve Dunning | Dick Woodson | Ed Farmer | 438 | 442 | -4 |
| 1972-09-03 | vs CLE | 124 | L 1-4 | 62-62 | 3 | 11,095 | Jim Perry | Dick Tidrow | Dick Tidrow | Jim Perry | | 439 | 446 | -7 |
| 1972-09-04 | @ CHA | 125 | W 2-1 | 64-62 | 3 | 0 | Bert Blyleven | Stan Bahnsen | Bert Blyleven | Stan Bahnsen | | 441 | 447 | -6 |
| 1972-09-04 | @ CHA | 126 | W 4-0 | 64-62 | 3 | 33,367 | Ray Corbin | Dave Lemonds | Ray Corbin | Dave Lemonds | | 445 | 447 | -2 |
| 1972-09-05 | @ CHA | 127 | L 2-5 | 64-63 | 3 | 6,784 | Dave Goltz | Eddie Fisher | Ken Frailing | Dave Goltz | Terry Forster | 447 | 452 | -5 |
| 1972-09-06 | @ TEX | 128 | W 2-0 | 65-63 | 3 | 4,223 | Dick Woodson | Bill Gogolewski | Dick Woodson | Bill Gogolewski | | 449 | 452 | -3 |
| 1972-09-07 | @ TEX | 129 | W 4-0 | 66-63 | 3 | 3,160 | Jim Perry | Dick Bosman | Jim Perry | Dick Bosman | Wayne Granger | 453 | 452 | 1 |
| 1972-09-08 | @ KCA | 130 | L 0-5 | 66-65 | 3 | 0 | Bert Blyleven | Tom Murphy | Tom Murphy | Bert Blyleven | | 453 | 457 | -4 |
| 1972-09-08 | @ KCA | 131 | L 2-3 | 66-65 | 3 | 7,541 | Ray Corbin | Steve Busby | Steve Busby | Ray Corbin | | 455 | 460 | -5 |
| 1972-09-09 | @ KCA | 132 | W 3-2 | 67-65 | 3 | 7,851 | Dave Goltz | Roger Nelson | Dave LaRoche | Ted Abernathy | | 458 | 462 | -4 |
| 1972-09-10 | @ KCA | 133 | L 1-3 | 67-66 | 3 | 8,785 | Dick Woodson | Dick Drago | Dick Drago | Dick Woodson | | 459 | 465 | -6 |
| 1972-09-11 | vs OAK | 134 | W 2-1 | 69-66 | 3 | 0 | Jim Perry | Vida Blue | Wayne Granger | Rollie Fingers | | 461 | 466 | -5 |
| 1972-09-11 | vs OAK | 135 | W 3-2 | 69-66 | 3 | 8,506 | Bert Blyleven | Joe Horlen | Bert Blyleven | Rollie Fingers | | 464 | 468 | -4 |
| 1972-09-12 | vs OAK | 136 | L 4-7 | 69-67 | 3 | 5,199 | Ray Corbin | Catfish Hunter | Darold Knowles | Ray Corbin | | 468 | 475 | -7 |
| 1972-09-13 | vs OAK | 137 | L 0-8 | 69-68 | 3 | 6,640 | Dave Goltz | Blue Moon Odom | Blue Moon Odom | Dave Goltz | | 468 | 483 | -15 |
| 1972-09-15 | vs KCA | 138 | W 4-3 | 70-68 | 3 | 6,416 | Dick Woodson | Roger Nelson | Dick Woodson | Roger Nelson | Dave LaRoche | 472 | 486 | -14 |
| 1972-09-16 | vs KCA | 139 | W 11-1 | 71-68 | 3 | 7,241 | Bert Blyleven | Dick Drago | Bert Blyleven | Dick Drago | | 483 | 487 | -4 |
| 1972-09-17 | vs KCA | 140 | L 6-10 | 71-69 | 3 | 7,275 | Jim Perry | Paul Splittorff | Norm Angelini | Bob Gebhard | Al Fitzmorris | 489 | 497 | -8 |
| 1972-09-19 | vs TEX | 141 | W 5-3 | 72-69 | 3 | 4,240 | Dick Woodson | Dick Bosman | Dave LaRoche | Paul Lindblad | | 494 | 500 | -6 |
| 1972-09-20 | vs TEX | 142 | W 3-1 | 73-69 | 3 | 3,678 | Jim Perry | Mike Paul | Jim Perry | Mike Paul | Wayne Granger | 497 | 501 | -4 |
| 1972-09-22 | vs CAL | 143 | W 1-0 | 74-69 | 3 | 9,494 | Bert Blyleven | Andy Messersmith | Bert Blyleven | Andy Messersmith | | 498 | 501 | -3 |
| 1972-09-23 | vs CAL | 144 | W 2-1 | 75-69 | 3 | 6,137 | Dick Woodson | Clyde Wright | Dick Woodson | Clyde Wright | Wayne Granger | 500 | 502 | -2 |
| 1972-09-24 | vs CAL | 145 | L 1-2 | 75-70 | 3 | 5,259 | Jim Perry | Rudy May | Rudy May | Jim Perry | | 501 | 504 | -3 |
| 1972-09-27 | @ OAK | 146 | L 0-1 | 75-72 | 3 | 0 | Bert Blyleven | Ken Holtzman | Bob Locker | Bert Blyleven | | 501 | 505 | -4 |
| 1972-09-27 | @ OAK | 147 | L 1-2 | 75-72 | 3 | 14,206 | Ray Corbin | Catfish Hunter | Catfish Hunter | Ray Corbin | | 502 | 507 | -5 |
| 1972-09-28 | @ OAK | 148 | L 7-8 | 75-73 | 3 | 9,155 | Dick Woodson | Blue Moon Odom | Rollie Fingers | Dave LaRoche | | 509 | 515 | -6 |
| 1972-09-29 | @ CAL | 149 | L 1-2 | 75-74 | 3 | 12,721 | Jim Perry | Rudy May | Rudy May | Jim Perry | Steve Barber | 510 | 517 | -7 |
| 1972-09-30 | @ CAL | 150 | L 2-3 | 75-75 | 3 | 5,901 | Dave Goltz | Nolan Ryan | Nolan Ryan | Dave Goltz | | 512 | 520 | -8 |
| 1972-10-01 | @ CAL | 151 | W 3-2 | 76-75 | 3 | 5,971 | Bert Blyleven | Andy Messersmith | Bert Blyleven | Andy Messersmith | Wayne Granger | 515 | 522 | -7 |
| 1972-10-02 | vs CHA | 152 | L 4-6 | 76-76 | 3 | 3,271 | Dick Woodson | Jim Geddes | Dave Lemonds | Dave LaRoche | Terry Forster | 519 | 528 | -9 |
| 1972-10-03 | vs CHA | 153 | L 4-5 | 76-77 | 3 | 2,568 | Ray Corbin | Eddie Fisher | Steve Kealey | Wayne Granger | | 523 | 533 | -10 |
| 1972-10-04 | vs CHA | 154 | W 14-2 | 77-77 | 3 | 3,193 | Bert Blyleven | Rich Gossage | Bert Blyleven | Rich Gossage | Dave Goltz | 537 | 535 | 2 |