| 1971-04-06 | @ DET | 1 | L 2-8 | 0-1 | 5 | 54,089 | Steve Hargan | Mickey Lolich | Mickey Lolich | Steve Hargan | | 2 | 8 | -6 |
| 1971-04-08 | vs BOS | 2 | W 3-2 | 1-1 | 4 | 40,462 | Sam McDowell | Sonny Siebert | Vince Colbert | Ken Tatum | | 5 | 10 | -5 |
| 1971-04-10 | vs BOS | 3 | W 11-10 | 2-1 | 2 | 4,955 | Steve Hargan | Cal Koonce | Camilo Pascual | Ken Brett | Chuck Machemehl | 16 | 20 | -4 |
| 1971-04-11 | vs BOS | 4 | W 7-2 | 3-1 | 2 | 6,005 | Alan Foster | Gary Peters | Alan Foster | Gary Peters | Chuck Machemehl | 23 | 22 | 1 |
| 1971-04-14 | vs BAL | 5 | L 0-3 | 3-2 | 2 | 4,676 | Sam McDowell | Mike Cuellar | Mike Cuellar | Sam McDowell | | 23 | 25 | -2 |
| 1971-04-15 | vs BAL | 6 | L 4-6 | 3-3 | 2 | 4,461 | Alan Foster | Jim Palmer | Jim Palmer | Chuck Machemehl | Eddie Watt | 27 | 31 | -4 |
| 1971-04-17 | vs WS2 | 7 | L 3-5 | 3-4 | 5 | 5,108 | Steve Hargan | Dick Bosman | Dick Bosman | Steve Hargan | Darold Knowles | 30 | 36 | -6 |
| 1971-04-18 | vs WS2 | 8 | L 0-4 | 4-5 | 5 | 0 | Sam McDowell | Denny McLain | Denny McLain | Sam McDowell | | 30 | 40 | -10 |
| 1971-04-18 | vs WS2 | 9 | W 1-0 | 4-5 | 5 | 11,400 | Steve Dunning | Casey Cox | Steve Dunning | Casey Cox | | 31 | 40 | -9 |
| 1971-04-19 | @ BOS | 10 | W 5-4 | 5-5 | 2 | 20,453 | Alan Foster | Mike Nagy | Steve Mingori | Bill Lee | Ray Lamb | 36 | 44 | -8 |
| 1971-04-20 | @ BOS | 11 | L 1-4 | 5-6 | 4 | 11,416 | Camilo Pascual | Gary Peters | Gary Peters | Camilo Pascual | Ken Tatum | 37 | 48 | -11 |
| 1971-04-21 | @ BOS | 12 | L 7-9 | 5-7 | 5 | 12,524 | Steve Hargan | Ray Culp | Sparky Lyle | Vince Colbert | Bobby Bolin | 44 | 57 | -13 |
| 1971-04-23 | @ KCA | 13 | L 2-5 | 5-8 | 6 | 7,696 | Sam McDowell | Dick Drago | Dick Drago | Sam McDowell | Tom Burgmeier | 46 | 62 | -16 |
| 1971-04-24 | @ KCA | 14 | L 0-6 | 5-9 | 6 | 7,625 | Alan Foster | Mike Hedlund | Mike Hedlund | Alan Foster | | 46 | 68 | -22 |
| 1971-04-25 | @ KCA | 15 | L 4-6 | 5-10 | 6 | 9,648 | Steve Hargan | Wally Bunker | Wally Bunker | Steve Hargan | Ken Wright | 50 | 74 | -24 |
| 1971-04-26 | @ CAL | 16 | L 0-8 | 5-11 | 6 | 5,153 | Steve Dunning | Rudy May | Rudy May | Steve Dunning | | 50 | 82 | -32 |
| 1971-04-27 | @ CAL | 17 | L 1-2 | 5-12 | 6 | 6,692 | Ray Lamb | Andy Messersmith | Lloyd Allen | Camilo Pascual | | 51 | 84 | -33 |
| 1971-04-28 | @ CAL | 18 | W 3-2 | 6-12 | 6 | 6,096 | Sam McDowell | Clyde Wright | Camilo Pascual | Mel Queen | Steve Mingori | 54 | 86 | -32 |
| 1971-04-29 | @ CAL | 19 | L 4-8 | 6-13 | 6 | 6,205 | Alan Foster | Tom Murphy | Eddie Fisher | Alan Foster | | 58 | 94 | -36 |
| 1971-04-30 | @ OAK | 20 | L 1-3 | 6-14 | 6 | 7,245 | Steve Hargan | Vida Blue | Vida Blue | Steve Hargan | | 59 | 97 | -38 |
| 1971-05-01 | @ OAK | 21 | W 2-1 | 7-14 | 6 | 7,564 | Steve Dunning | Diego Segui | Steve Dunning | Diego Segui | Chuck Machemehl | 61 | 98 | -37 |
| 1971-05-02 | @ OAK | 22 | L 5-8 | 8-15 | 6 | 0 | Sam McDowell | Catfish Hunter | Catfish Hunter | Sam McDowell | Bob Locker | 66 | 106 | -40 |
| 1971-05-02 | @ OAK | 23 | W 7-3 | 8-15 | 6 | 10,383 | Ray Lamb | Chuck Dobson | Sam McDowell | Ron Klimkowski | | 73 | 109 | -36 |
| 1971-05-04 | vs KCA | 24 | L 0-2 | 8-16 | 6 | 2,931 | Steve Hargan | Bruce Dal Canton | Bruce Dal Canton | Steve Hargan | Ted Abernathy | 73 | 111 | -38 |
| 1971-05-05 | vs KCA | 25 | L 2-4 | 8-17 | 6 | 3,056 | Steve Dunning | Dick Drago | Dick Drago | Steve Dunning | Tom Burgmeier | 75 | 115 | -40 |
| 1971-05-07 | vs CAL | 26 | L 2-4 | 8-18 | 6 | 4,602 | Sam McDowell | Clyde Wright | Mel Queen | Chuck Machemehl | Eddie Fisher | 77 | 119 | -42 |
| 1971-05-08 | vs CAL | 27 | L 2-5 | 8-19 | 6 | 4,295 | Ray Lamb | Rudy May | Rudy May | Rich Hand | Dave LaRoche | 79 | 124 | -45 |
| 1971-05-09 | vs CAL | 28 | W 4-1 | 9-19 | 6 | 4,288 | Alan Foster | Tom Murphy | Alan Foster | Tom Murphy | | 83 | 125 | -42 |
| 1971-05-11 | vs OAK | 29 | W 7-5 | 10-19 | 6 | 2,992 | Steve Dunning | Diego Segui | Phil Hennigan | Rollie Fingers | | 90 | 130 | -40 |
| 1971-05-12 | vs OAK | 30 | L 1-8 | 10-20 | 6 | 3,030 | Sam McDowell | Chuck Dobson | Chuck Dobson | Sam McDowell | | 91 | 138 | -47 |
| 1971-05-14 | @ NYA | 31 | W 2-1 | 11-20 | 6 | 10,541 | Ray Lamb | Steve Kline | Ray Lamb | Steve Kline | | 93 | 139 | -46 |
| 1971-05-15 | @ NYA | 32 | W 4-2 | 12-20 | 6 | 9,459 | Alan Foster | Stan Bahnsen | Alan Foster | Stan Bahnsen | Phil Hennigan | 97 | 141 | -44 |
| 1971-05-17 | @ WS2 | 33 | W 6-3 | 13-20 | 6 | 3,186 | Steve Dunning | Dick Bosman | Steve Dunning | Dick Bosman | Phil Hennigan | 103 | 144 | -41 |
| 1971-05-18 | @ WS2 | 34 | W 7-3 | 14-20 | 6 | 5,690 | Sam McDowell | Denny McLain | Sam McDowell | Denny McLain | Vince Colbert | 110 | 147 | -37 |
| 1971-05-19 | vs DET | 35 | L 1-12 | 14-21 | 6 | 4,284 | Ray Lamb | Mickey Lolich | Mickey Lolich | Ray Lamb | Bill Denehy | 111 | 159 | -48 |
| 1971-05-20 | vs DET | 36 | L 3-5 | 14-22 | 6 | 3,311 | Alan Foster | Joe Coleman | Fred Scherman | Steve Mingori | | 114 | 164 | -50 |
| 1971-05-21 | vs NYA | 37 | W 8-7 | 15-22 | 5 | 6,981 | Rich Hand | Mike Kekich | Phil Hennigan | Lindy McDaniel | | 122 | 171 | -49 |
| 1971-05-22 | vs NYA | 38 | W 2-1 | 16-22 | 5 | 10,351 | Steve Dunning | Mel Stottlemyre | Steve Dunning | Mel Stottlemyre | | 124 | 172 | -48 |
| 1971-05-23 | vs NYA | 39 | L 3-6 | 17-23 | 5 | 0 | Ray Lamb | Fritz Peterson | Fritz Peterson | Ray Lamb | | 127 | 178 | -51 |
| 1971-05-23 | vs NYA | 40 | W 2-1 | 17-23 | 5 | 19,014 | Sam McDowell | Steve Kline | Sam McDowell | Steve Kline | | 129 | 179 | -50 |
| 1971-05-26 | @ BAL | 41 | L 2-3 | 17-24 | 5 | 8,865 | Rich Hand | Mike Cuellar | Mike Cuellar | Rich Hand | | 131 | 182 | -51 |
| 1971-05-27 | @ BAL | 42 | W 10-5 | 18-24 | 4 | 6,054 | Steve Dunning | Jim Palmer | Steve Dunning | Tom Dukes | Phil Hennigan | 141 | 187 | -46 |
| 1971-05-28 | @ CHA | 43 | W 4-0 | 19-24 | 4 | 10,005 | Sam McDowell | Bart Johnson | Sam McDowell | Bart Johnson | | 145 | 187 | -42 |
| 1971-05-29 | @ CHA | 44 | W 2-1 | 20-24 | 4 | 10,231 | Ray Lamb | Tom Bradley | Ray Lamb | Tom Bradley | | 147 | 188 | -41 |
| 1971-05-30 | @ CHA | 45 | L 2-3 | 20-25 | 4 | 12,295 | Alan Foster | Wilbur Wood | Terry Forster | Phil Hennigan | | 149 | 191 | -42 |
| 1971-05-31 | @ MIL | 46 | L 5-6 | 20-26 | 5 | 4,221 | Rich Hand | Skip Lockwood | Ken Sanders | Phil Hennigan | | 154 | 197 | -43 |
| 1971-06-01 | @ MIL | 47 | L 3-5 | 20-27 | 5 | 4,020 | Steve Dunning | Marty Pattin | Marty Pattin | Steve Dunning | | 157 | 202 | -45 |
| 1971-06-02 | @ MIL | 48 | W 4-2 | 21-27 | 5 | 5,359 | Sam McDowell | Bill Parsons | Sam McDowell | Bill Parsons | Rick Austin | 161 | 204 | -43 |
| 1971-06-04 | @ MIN | 49 | W 4-2 | 22-27 | 4 | 10,494 | Alan Foster | Bert Blyleven | Alan Foster | Bert Blyleven | | 165 | 206 | -41 |
| 1971-06-05 | @ MIN | 50 | W 10-2 | 23-27 | 4 | 10,331 | Ray Lamb | Jim Kaat | Ray Lamb | Jim Kaat | Phil Hennigan | 175 | 208 | -33 |
| 1971-06-06 | @ MIN | 51 | L 3-4 | 23-28 | 4 | 12,146 | Steve Dunning | Jim Perry | Jim Perry | Steve Dunning | Tom Hall | 178 | 212 | -34 |
| 1971-06-08 | vs CHA | 52 | W 5-3 | 24-28 | 4 | 3,238 | Sam McDowell | Wilbur Wood | Sam McDowell | Wilbur Wood | | 183 | 215 | -32 |
| 1971-06-09 | vs CHA | 53 | W 3-1 | 25-28 | 4 | 3,951 | Alan Foster | Tommy John | Alan Foster | Tommy John | Ed Farmer | 186 | 216 | -30 |
| 1971-06-10 | vs CHA | 54 | W 9-0 | 26-28 | 4 | 4,265 | Ray Lamb | Tom Bradley | Ray Lamb | Tom Bradley | | 195 | 216 | -21 |
| 1971-06-11 | vs MIL | 55 | W 2-1 | 27-28 | 4 | 9,155 | Steve Dunning | Marty Pattin | Steve Dunning | Marty Pattin | Ed Farmer | 197 | 217 | -20 |
| 1971-06-12 | vs MIL | 56 | L 2-4 | 27-29 | 4 | 11,262 | Rich Hand | Jim Slaton | John Morris | Rich Hand | | 199 | 221 | -22 |
| 1971-06-13 | vs MIL | 57 | W 11-0 | 28-29 | 4 | 8,934 | Sam McDowell | Bill Parsons | Sam McDowell | Bill Parsons | | 210 | 221 | -11 |
| 1971-06-14 | vs MIN | 58 | L 1-3 | 28-30 | 4 | 15,394 | Alan Foster | Jim Perry | Jim Perry | Alan Foster | | 211 | 224 | -13 |
| 1971-06-15 | vs MIN | 59 | L 3-5 | 28-31 | 4 | 6,238 | Ray Lamb | Bert Blyleven | Bert Blyleven | Ray Lamb | Ray Corbin | 214 | 229 | -15 |
| 1971-06-16 | vs MIN | 60 | L 2-3 | 28-32 | 5 | 6,220 | Steve Dunning | Jim Kaat | Tom Hall | Steve Mingori | Stan Williams | 216 | 232 | -16 |
| 1971-06-17 | vs DET | 61 | L 3-4 | 28-33 | 5 | 6,732 | Sam McDowell | Les Cain | Les Cain | Sam McDowell | Fred Scherman | 219 | 236 | -17 |
| 1971-06-18 | vs DET | 62 | W 7-0 | 29-33 | 4 | 12,084 | Rich Hand | Joe Coleman | Rich Hand | Joe Coleman | Vince Colbert | 226 | 236 | -10 |
| 1971-06-19 | vs DET | 63 | L 3-5 | 29-34 | 5 | 13,818 | Alan Foster | Dean Chance | Joe Niekro | Alan Foster | Fred Scherman | 229 | 241 | -12 |
| 1971-06-20 | vs DET | 64 | W 7-6 | 31-34 | 4 | 0 | Steve Dunning | Mickey Lolich | Vince Colbert | Fred Scherman | | 236 | 247 | -11 |
| 1971-06-20 | vs DET | 65 | W 8-7 | 31-34 | 4 | 50,669 | Ed Farmer | Bill Zepp | Sam McDowell | Tom Timmermann | | 244 | 254 | -10 |
| 1971-06-22 | @ BOS | 66 | W 9-3 | 32-35 | 4 | 0 | Steve Hargan | Bill Lee | Steve Hargan | Bill Lee | Phil Hennigan | 253 | 257 | -4 |
| 1971-06-22 | @ BOS | 67 | L 0-2 | 32-35 | 4 | 25,578 | Rich Hand | Sonny Siebert | Sonny Siebert | Rich Hand | | 253 | 259 | -6 |
| 1971-06-23 | @ BOS | 68 | L 1-2 | 32-36 | 4 | 17,513 | Sam McDowell | Ray Culp | Ray Culp | Sam McDowell | | 254 | 261 | -7 |
| 1971-06-24 | @ DET | 69 | L 0-3 | 32-37 | 4 | 17,900 | Alan Foster | Mickey Lolich | Mickey Lolich | Alan Foster | | 254 | 264 | -10 |
| 1971-06-25 | @ DET | 70 | L 1-6 | 32-38 | 5 | 24,714 | Steve Dunning | Bill Gilbreth | Bill Gilbreth | Steve Dunning | | 255 | 270 | -15 |
| 1971-06-26 | @ DET | 71 | L 0-1 | 32-39 | 5 | 34,447 | Steve Hargan | Joe Coleman | Joe Coleman | Steve Hargan | | 255 | 271 | -16 |
| 1971-06-27 | @ DET | 72 | W 3-1 | 33-39 | 5 | 21,734 | Sam McDowell | Mike Kilkenny | Sam McDowell | Mike Kilkenny | | 258 | 272 | -14 |
| 1971-06-28 | @ NYA | 73 | W 3-0 | 35-39 | 4 | 0 | Ray Lamb | Fritz Peterson | Ray Lamb | Fritz Peterson | Steve Mingori | 261 | 272 | -11 |
| 1971-06-28 | @ NYA | 74 | W 5-2 | 35-39 | 4 | 11,690 | Rich Hand | Jim Hardin | Phil Hennigan | Lindy McDaniel | Steve Mingori | 266 | 274 | -8 |
| 1971-06-29 | @ NYA | 75 | L 2-9 | 35-40 | 4 | 7,192 | Alan Foster | Steve Kline | Steve Kline | Alan Foster | | 268 | 283 | -15 |
| 1971-06-30 | vs BAL | 76 | W 5-4 | 36-41 | 4 | 0 | Steve Dunning | Mike Cuellar | Phil Hennigan | Pete Richert | | 273 | 287 | -14 |
| 1971-06-30 | vs BAL | 77 | L 3-4 | 36-41 | 4 | 13,945 | Steve Hargan | Grant Jackson | Grant Jackson | Steve Hargan | Dick Hall | 276 | 291 | -15 |
| 1971-07-01 | vs BAL | 78 | W 3-2 | 37-41 | 4 | 7,862 | Sam McDowell | Jim Palmer | Ed Farmer | Eddie Watt | | 279 | 293 | -14 |
| 1971-07-02 | vs WS2 | 79 | L 3-6 | 37-42 | 4 | 12,087 | Ray Lamb | Dick Bosman | Dick Bosman | Ray Lamb | Paul Lindblad | 282 | 299 | -17 |
| 1971-07-03 | vs WS2 | 80 | L 3-4 | 37-43 | 4 | 4,849 | Alan Foster | Jackie Brown | Jackie Brown | Alan Foster | Joe Grzenda | 285 | 303 | -18 |
| 1971-07-04 | vs WS2 | 81 | L 4-9 | 37-44 | 4 | 11,264 | Steve Dunning | Pete Broberg | Pete Broberg | Steve Dunning | | 289 | 312 | -23 |
| 1971-07-05 | vs WS2 | 82 | L 6-15 | 37-45 | 4 | 13,813 | Steve Hargan | Denny McLain | Paul Lindblad | Steve Hargan | Denny Riddleberger | 295 | 327 | -32 |
| 1971-07-06 | vs BOS | 83 | L 2-3 | 37-46 | 4 | 9,309 | Ray Lamb | Sonny Siebert | Sonny Siebert | Ray Lamb | Gary Peters | 297 | 330 | -33 |
| 1971-07-07 | vs BOS | 84 | L 0-4 | 38-47 | 5 | 0 | Alan Foster | Ray Culp | Ray Culp | Alan Foster | | 297 | 334 | -37 |
| 1971-07-07 | vs BOS | 85 | W 4-3 | 38-47 | 5 | 8,582 | Rich Hand | Luis Tiant | Ed Farmer | Luis Tiant | Phil Hennigan | 301 | 337 | -36 |
| 1971-07-08 | vs BOS | 86 | L 3-5 | 38-48 | 5 | 8,305 | Steve Hargan | Jim Lonborg | Bill Lee | Vince Colbert | Sparky Lyle | 304 | 342 | -38 |
| 1971-07-09 | @ BAL | 87 | L 1-4 | 38-49 | 5 | 34,374 | Steve Dunning | Jim Palmer | Jim Palmer | Steve Dunning | | 305 | 346 | -41 |
| 1971-07-10 | @ BAL | 88 | L 3-11 | 39-50 | 5 | 0 | Sam McDowell | Grant Jackson | Dave Leonhard | Sam McDowell | | 308 | 357 | -49 |
| 1971-07-10 | @ BAL | 89 | W 3-2 | 39-50 | 5 | 21,464 | Mike Paul | Dave Boswell | Mike Paul | Dave Boswell | Phil Hennigan | 311 | 359 | -48 |
| 1971-07-11 | @ BAL | 90 | L 1-7 | 39-51 | 5 | 16,071 | Ed Farmer | Pat Dobson | Pat Dobson | Steve Hargan | | 312 | 366 | -54 |
| 1971-07-15 | @ KCA | 91 | L 0-1 | 39-52 | 5 | 9,663 | Sam McDowell | Dick Drago | Dick Drago | Sam McDowell | | 312 | 367 | -55 |
| 1971-07-16 | @ KCA | 92 | W 8-4 | 40-52 | 5 | 11,221 | Steve Dunning | Bruce Dal Canton | Steve Dunning | Bruce Dal Canton | Phil Hennigan | 320 | 371 | -51 |
| 1971-07-17 | @ KCA | 93 | L 2-7 | 40-53 | 5 | 10,319 | Ray Lamb | Mike Hedlund | Mike Hedlund | Ray Lamb | Tom Burgmeier | 322 | 378 | -56 |
| 1971-07-18 | @ CAL | 94 | L 1-3 | 40-54 | 5 | 10,607 | Alan Foster | Rudy May | Rudy May | Alan Foster | | 323 | 381 | -58 |
| 1971-07-19 | @ CAL | 95 | W 3-1 | 41-54 | 5 | 8,100 | Sam McDowell | Rickey Clark | Sam McDowell | Rickey Clark | | 326 | 382 | -56 |
| 1971-07-20 | @ OAK | 96 | L 3-6 | 41-55 | 5 | 8,539 | Ray Lamb | Chuck Dobson | Chuck Dobson | Ray Lamb | Rollie Fingers | 329 | 388 | -59 |
| 1971-07-21 | @ OAK | 97 | L 3-4 | 41-56 | 5 | 21,353 | Steve Dunning | Vida Blue | Darold Knowles | Phil Hennigan | | 332 | 392 | -60 |
| 1971-07-23 | vs KCA | 98 | L 4-6 | 41-57 | 5 | 14,004 | Sam McDowell | Paul Splittorff | Jim Rooker | Sam McDowell | Tom Burgmeier | 336 | 398 | -62 |
| 1971-07-24 | vs KCA | 99 | L 1-6 | 41-58 | 6 | 8,930 | Alan Foster | Bill Butler | Jim York | Alan Foster | | 337 | 404 | -67 |
| 1971-07-25 | vs KCA | 100 | L 3-4 | 42-59 | 5 | 0 | Ray Lamb | Dick Drago | Dick Drago | Ray Lamb | | 340 | 408 | -68 |
| 1971-07-25 | vs KCA | 101 | W 2-1 | 42-59 | 5 | 12,247 | Mike Paul | Bruce Dal Canton | Ed Farmer | Tom Burgmeier | Steve Mingori | 342 | 409 | -67 |
| 1971-07-27 | vs CAL | 102 | W 4-3 | 43-59 | 5 | 8,016 | Sam McDowell | Clyde Wright | Sam McDowell | Clyde Wright | | 346 | 412 | -66 |
| 1971-07-28 | vs CAL | 103 | L 1-5 | 43-60 | 5 | 3,512 | Steve Hargan | Rudy May | Rudy May | Steve Hargan | | 347 | 417 | -70 |
| 1971-07-29 | vs CAL | 104 | L 2-7 | 43-61 | 5 | 3,272 | Mike Paul | Tom Murphy | Eddie Fisher | Mike Paul | | 349 | 424 | -75 |
| 1971-07-30 | vs OAK | 105 | W 4-1 | 44-61 | 5 | 10,045 | Alan Foster | Vida Blue | Alan Foster | Vida Blue | Phil Hennigan | 353 | 425 | -72 |
| 1971-07-31 | vs OAK | 106 | L 1-9 | 44-62 | 6 | 15,341 | Steve Dunning | Chuck Dobson | Chuck Dobson | Steve Dunning | | 354 | 434 | -80 |
| 1971-08-01 | vs OAK | 107 | L 3-7 | 44-64 | 6 | 0 | Steve Hargan | Catfish Hunter | Catfish Hunter | Steve Hargan | | 357 | 441 | -84 |
| 1971-08-01 | vs OAK | 108 | L 2-4 | 44-64 | 6 | 12,974 | Vince Colbert | Blue Moon Odom | Blue Moon Odom | Ray Lamb | Rollie Fingers | 359 | 445 | -86 |
| 1971-08-02 | vs NYA | 109 | L 0-7 | 44-65 | 6 | 8,025 | Mike Paul | Fritz Peterson | Fritz Peterson | Mike Paul | | 359 | 452 | -93 |
| 1971-08-03 | vs NYA | 110 | L 1-8 | 44-66 | 6 | 5,084 | Alan Foster | Mike Kekich | Mike Kekich | Alan Foster | | 360 | 460 | -100 |
| 1971-08-04 | vs NYA | 111 | L 3-7 | 44-67 | 6 | 4,721 | Ray Lamb | Stan Bahnsen | Stan Bahnsen | Ray Lamb | Lindy McDaniel | 363 | 467 | -104 |
| 1971-08-05 | @ WS2 | 112 | W 7-1 | 45-67 | 6 | 4,694 | Vince Colbert | Mike Thompson | Vince Colbert | Mike Thompson | Ed Farmer | 370 | 468 | -98 |
| 1971-08-06 | @ WS2 | 113 | L 3-7 | 45-68 | 6 | 8,211 | Steve Hargan | Bill Gogolewski | Bill Gogolewski | Steve Hargan | | 373 | 475 | -102 |
| 1971-08-07 | @ WS2 | 114 | L 0-7 | 45-69 | 6 | 5,202 | Mike Paul | Pete Broberg | Pete Broberg | Mike Paul | | 373 | 482 | -109 |
| 1971-08-08 | @ WS2 | 115 | W 6-2 | 46-69 | 6 | 13,921 | Steve Dunning | Denny McLain | Steve Dunning | Denny McLain | Phil Hennigan | 379 | 484 | -105 |
| 1971-08-10 | @ CHA | 116 | W 4-1 | 47-69 | 6 | 17,337 | Sam McDowell | Tom Bradley | Sam McDowell | Tom Bradley | Phil Hennigan | 383 | 485 | -102 |
| 1971-08-11 | @ CHA | 117 | W 3-2 | 48-69 | 5 | 8,826 | Ray Lamb | Joe Horlen | Ed Farmer | Rich Hinton | | 386 | 487 | -101 |
| 1971-08-12 | @ CHA | 118 | W 6-2 | 49-69 | 5 | 8,836 | Mike Paul | Wilbur Wood | Alan Foster | Wilbur Wood | | 392 | 489 | -97 |
| 1971-08-13 | @ MIL | 119 | L 1-9 | 49-70 | 5 | 7,204 | Steve Dunning | Jim Slaton | Jim Slaton | Steve Dunning | | 393 | 498 | -105 |
| 1971-08-14 | @ MIL | 120 | L 3-5 | 49-71 | 6 | 6,005 | Vince Colbert | Lew Krausse | Lew Krausse | Vince Colbert | Ken Sanders | 396 | 503 | -107 |
| 1971-08-15 | @ MIL | 121 | L 2-4 | 49-72 | 6 | 22,604 | Sam McDowell | Bill Parsons | Bill Parsons | Sam McDowell | Ken Sanders | 398 | 507 | -109 |
| 1971-08-16 | @ MIN | 122 | L 2-11 | 49-73 | 6 | 9,372 | Ray Lamb | Jim Kaat | Jim Kaat | Ray Lamb | | 400 | 518 | -118 |
| 1971-08-17 | @ MIN | 123 | W 3-2 | 50-73 | 6 | 10,926 | Mike Paul | Bert Blyleven | Mike Paul | Bert Blyleven | | 403 | 520 | -117 |
| 1971-08-18 | @ MIN | 124 | L 2-4 | 50-74 | 6 | 8,971 | Steve Dunning | Steve Luebber | Steve Luebber | Steve Dunning | Jim Strickland | 405 | 524 | -119 |
| 1971-08-20 | vs CHA | 125 | L 1-9 | 50-75 | 6 | 7,256 | Vince Colbert | Tom Bradley | Tom Bradley | Vince Colbert | Bart Johnson | 406 | 533 | -127 |
| 1971-08-21 | vs CHA | 126 | W 9-4 | 51-75 | 6 | 11,078 | Ray Lamb | Tommy John | Ray Lamb | Tommy John | Ed Farmer | 415 | 537 | -122 |
| 1971-08-22 | vs CHA | 127 | L 3-5 | 51-76 | 6 | 5,124 | Steve Dunning | Wilbur Wood | Wilbur Wood | Steve Dunning | Bart Johnson | 418 | 542 | -124 |
| 1971-08-24 | vs MIL | 128 | L 5-6 | 51-77 | 6 | 6,533 | Alan Foster | Jim Slaton | Ken Sanders | Ed Farmer | | 423 | 548 | -125 |
| 1971-08-25 | vs MIL | 129 | L 8-10 | 51-78 | 6 | 2,954 | Mike Paul | Bill Parsons | Bill Parsons | Mike Paul | Ken Sanders | 431 | 558 | -127 |
| 1971-08-26 | vs MIL | 130 | W 10-6 | 52-78 | 6 | 2,804 | Ray Lamb | Skip Lockwood | Ed Farmer | Skip Lockwood | Phil Hennigan | 441 | 564 | -123 |
| 1971-08-27 | vs MIN | 131 | L 4-8 | 52-79 | 6 | 15,899 | Steve Dunning | Bert Blyleven | Bert Blyleven | Steve Dunning | | 445 | 572 | -127 |
| 1971-08-28 | vs MIN | 132 | W 9-8 | 53-79 | 6 | 5,663 | Alan Foster | Steve Luebber | Mark Ballinger | Ray Corbin | | 454 | 580 | -126 |
| 1971-08-29 | vs MIN | 133 | L 5-6 | 53-80 | 6 | 5,121 | Sam McDowell | Jim Perry | Jim Perry | Sam McDowell | Hal Haydel | 459 | 586 | -127 |
| 1971-08-31 | @ DET | 134 | L 1-6 | 54-81 | 6 | 0 | Ed Farmer | Joe Coleman | Joe Coleman | Ed Farmer | | 460 | 592 | -132 |
| 1971-08-31 | @ DET | 135 | W 6-3 | 54-81 | 6 | 27,209 | Vince Colbert | Joe Niekro | Vince Colbert | Joe Niekro | Sam McDowell | 466 | 595 | -129 |
| 1971-09-01 | @ DET | 136 | L 3-4 | 54-82 | 6 | 8,455 | Mike Paul | Les Cain | Les Cain | Mike Paul | Fred Scherman | 469 | 599 | -130 |
| 1971-09-02 | @ DET | 137 | L 0-7 | 54-83 | 6 | 15,500 | Steve Dunning | Mickey Lolich | Mickey Lolich | Steve Dunning | | 469 | 606 | -137 |
| 1971-09-03 | @ BOS | 138 | L 2-9 | 54-84 | 6 | 16,086 | Sam McDowell | Roger Moret | Roger Moret | Sam McDowell | | 471 | 615 | -144 |
| 1971-09-04 | @ BOS | 139 | W 11-9 | 55-84 | 6 | 16,506 | Rich Hand | Jim Lonborg | Rich Hand | Jim Lonborg | Phil Hennigan | 482 | 624 | -142 |
| 1971-09-05 | @ BOS | 140 | L 1-8 | 55-85 | 6 | 22,820 | Ed Farmer | Gary Peters | Gary Peters | Ed Farmer | | 483 | 632 | -149 |
| 1971-09-06 | @ BAL | 141 | L 5-10 | 56-86 | 6 | 0 | Mike Paul | Pat Dobson | Eddie Watt | Mark Ballinger | | 488 | 642 | -154 |
| 1971-09-06 | @ BAL | 142 | W 1-0 | 56-86 | 6 | 16,088 | Vince Colbert | Dave Leonhard | Vince Colbert | Dave Leonhard | Steve Dunning | 489 | 642 | -153 |
| 1971-09-07 | @ BAL | 143 | L 1-3 | 56-87 | 6 | 7,196 | Sam McDowell | Dave McNally | Dave McNally | Sam McDowell | | 490 | 645 | -155 |
| 1971-09-11 | vs NYA | 144 | L 8-10 | 56-88 | 6 | 4,925 | Rich Hand | Mike Kekich | Mike Kekich | Rich Hand | Roger Hambright | 498 | 655 | -157 |
| 1971-09-12 | vs NYA | 145 | W 5-2 | 57-88 | 6 | 7,556 | Sam McDowell | Fritz Peterson | Sam McDowell | Fritz Peterson | Phil Hennigan | 503 | 657 | -154 |
| 1971-09-14 | vs WS2 | 146 | W 3-1 | 58-89 | 6 | 0 | Vince Colbert | Bill Gogolewski | Vince Colbert | Bill Gogolewski | | 506 | 658 | -152 |
| 1971-09-14 | vs WS2 | 147 | L 6-8 | 58-89 | 6 | 2,639 | Steve Dunning | Pete Broberg | Denny McLain | Sam McDowell | | 512 | 666 | -154 |
| 1971-09-15 | vs BOS | 148 | L 5-6 | 58-90 | 6 | 2,449 | Alan Foster | Jim Lonborg | Sparky Lyle | Ed Farmer | Ken Brett | 517 | 672 | -155 |
| 1971-09-16 | vs BOS | 149 | L 7-10 | 58-91 | 6 | 2,301 | Rich Hand | Mike Garman | John Curtis | Ray Lamb | Sparky Lyle | 524 | 682 | -158 |
| 1971-09-17 | @ NYA | 150 | L 0-1 | 58-93 | 6 | 0 | Sam McDowell | Fritz Peterson | Fritz Peterson | Sam McDowell | | 524 | 683 | -159 |
| 1971-09-17 | @ NYA | 151 | L 1-7 | 58-93 | 6 | 7,527 | Mike Paul | Stan Bahnsen | Stan Bahnsen | Mike Paul | | 525 | 690 | -165 |
| 1971-09-18 | @ NYA | 152 | L 0-9 | 58-94 | 6 | 9,105 | Vince Colbert | Mel Stottlemyre | Mel Stottlemyre | Vince Colbert | | 525 | 699 | -174 |
| 1971-09-19 | @ NYA | 153 | L 2-3 | 58-95 | 6 | 9,177 | Steve Dunning | Steve Kline | Steve Kline | Steve Dunning | | 527 | 702 | -175 |
| 1971-09-20 | @ WS2 | 154 | W 3-1 | 59-95 | 6 | 1,743 | Alan Foster | Denny McLain | Alan Foster | Denny McLain | Steve Hargan | 530 | 703 | -173 |
| 1971-09-21 | @ WS2 | 155 | L 1-9 | 59-96 | 6 | 1,311 | Rich Hand | Dick Bosman | Dick Bosman | Rich Hand | | 531 | 712 | -181 |
| 1971-09-22 | @ WS2 | 156 | L 2-3 | 59-97 | 6 | 1,458 | Vince Colbert | Bill Gogolewski | Bill Gogolewski | Vince Colbert | Joe Grzenda | 533 | 715 | -182 |
| 1971-09-24 | vs BAL | 157 | L 2-9 | 59-99 | 6 | 0 | Sam McDowell | Mike Cuellar | Mike Cuellar | Sam McDowell | | 535 | 724 | -189 |
| 1971-09-24 | vs BAL | 158 | L 0-7 | 59-99 | 6 | 3,511 | Mike Paul | Pat Dobson | Pat Dobson | Mike Paul | | 535 | 731 | -196 |
| 1971-09-25 | vs BAL | 159 | L 4-6 | 59-100 | 6 | 3,307 | Steve Dunning | Dave Leonhard | Pete Richert | Mark Ballinger | Eddie Watt | 539 | 737 | -198 |
| 1971-09-26 | vs BAL | 160 | L 0-5 | 59-101 | 6 | 2,967 | Alan Foster | Jim Palmer | Jim Palmer | Alan Foster | | 539 | 742 | -203 |
| 1971-09-28 | vs DET | 161 | L 2-4 | 59-102 | 6 | 2,266 | Steve Hargan | Joe Coleman | Joe Coleman | Steve Hargan | | 541 | 746 | -205 |
| 1971-09-29 | vs DET | 162 | W 2-1 | 60-102 | 6 | 2,596 | Vince Colbert | Mickey Lolich | Vince Colbert | Mickey Lolich | | 543 | 747 | -204 |