| 1971-04-06 | vs NYA | 1 | W 3-1 | 1-0 | 1 | 34,517 | Ray Culp | Stan Bahnsen | Ray Culp | Stan Bahnsen | | 3 | 1 | 2 |
| 1971-04-08 | @ CLE | 2 | L 2-3 | 1-1 | 3 | 40,462 | Sonny Siebert | Sam McDowell | Vince Colbert | Ken Tatum | | 5 | 4 | 1 |
| 1971-04-10 | @ CLE | 3 | L 10-11 | 1-2 | 4 | 4,955 | Cal Koonce | Steve Hargan | Camilo Pascual | Ken Brett | Chuck Machemehl | 15 | 15 | 0 |
| 1971-04-11 | @ CLE | 4 | L 2-7 | 1-3 | 6 | 6,005 | Gary Peters | Alan Foster | Alan Foster | Gary Peters | Chuck Machemehl | 17 | 22 | -5 |
| 1971-04-12 | @ WS2 | 5 | W 10-7 | 2-3 | 4 | 7,392 | Ray Culp | Gerry Janeski | Ray Culp | Gerry Janeski | Ken Tatum | 27 | 29 | -2 |
| 1971-04-13 | @ WS2 | 6 | W 5-3 | 3-3 | 3 | 12,154 | Sonny Siebert | Denny McLain | Sonny Siebert | Denny McLain | Sparky Lyle | 32 | 32 | 0 |
| 1971-04-14 | @ WS2 | 7 | L 5-6 | 3-4 | 5 | 4,286 | Mike Nagy | Jim Shellenback | Darold Knowles | Bobby Bolin | Gerry Janeski | 37 | 38 | -1 |
| 1971-04-16 | @ DET | 8 | W 5-3 | 4-4 | 2 | 14,963 | Gary Peters | Joe Niekro | Gary Peters | Joe Niekro | Sparky Lyle | 42 | 41 | 1 |
| 1971-04-17 | @ DET | 9 | L 9-10 | 4-5 | 4 | 15,758 | Ray Culp | Mickey Lolich | Tom Timmermann | Ken Tatum | | 51 | 51 | 0 |
| 1971-04-18 | @ DET | 10 | W 1-0 | 5-5 | 2 | 19,606 | Sonny Siebert | Dean Chance | Sonny Siebert | Dean Chance | | 52 | 51 | 1 |
| 1971-04-19 | vs CLE | 11 | L 4-5 | 5-6 | 4 | 20,453 | Mike Nagy | Alan Foster | Steve Mingori | Bill Lee | Ray Lamb | 56 | 56 | 0 |
| 1971-04-20 | vs CLE | 12 | W 4-1 | 6-6 | 3 | 11,416 | Gary Peters | Camilo Pascual | Gary Peters | Camilo Pascual | Ken Tatum | 60 | 57 | 3 |
| 1971-04-21 | vs CLE | 13 | W 9-7 | 7-6 | 3 | 12,524 | Ray Culp | Steve Hargan | Sparky Lyle | Vince Colbert | Bobby Bolin | 69 | 64 | 5 |
| 1971-04-23 | vs CHA | 14 | W 7-1 | 8-6 | 2 | 12,261 | Sonny Siebert | Tommy John | Sonny Siebert | Tommy John | | 76 | 65 | 11 |
| 1971-04-24 | vs CHA | 15 | W 4-2 | 9-6 | 2 | 17,386 | Mike Nagy | Bart Johnson | Mike Nagy | Vicente Romo | Ken Tatum | 80 | 67 | 13 |
| 1971-04-25 | vs CHA | 16 | W 5-4 | 10-6 | 2 | 13,112 | Gary Peters | Wilbur Wood | Sparky Lyle | Don Eddy | Ken Tatum | 85 | 71 | 14 |
| 1971-04-27 | vs MIL | 17 | L 2-4 | 10-7 | 2 | 11,361 | Ray Culp | Marty Pattin | Marty Pattin | Ray Culp | | 87 | 75 | 12 |
| 1971-04-28 | vs MIL | 18 | W 10-3 | 11-7 | 2 | 4,437 | Sonny Siebert | Bill Parsons | Sonny Siebert | Bill Parsons | Ken Tatum | 97 | 78 | 19 |
| 1971-04-30 | vs MIN | 19 | W 4-3 | 12-7 | 1 | 18,108 | Mike Nagy | Jim Kaat | Bill Lee | Jim Kaat | Sparky Lyle | 101 | 81 | 20 |
| 1971-05-01 | vs MIN | 20 | L 3-7 | 12-8 | 1 | 16,494 | Gary Peters | Jim Perry | Jim Perry | Gary Peters | | 104 | 88 | 16 |
| 1971-05-02 | vs MIN | 21 | W 1-0 | 14-8 | 1 | 0 | Ray Culp | Bert Blyleven | Ray Culp | Bert Blyleven | | 105 | 88 | 17 |
| 1971-05-02 | vs MIN | 22 | W 9-8 | 14-8 | 1 | 23,163 | Sonny Siebert | Steve Barber | Ken Tatum | Ron Perranoski | | 114 | 96 | 18 |
| 1971-05-04 | @ CHA | 23 | W 4-3 | 15-8 | 1 | 4,998 | Mike Nagy | Tom Bradley | Bill Lee | Tom Bradley | Sparky Lyle | 118 | 99 | 19 |
| 1971-05-06 | @ CHA | 24 | W 10-1 | 16-8 | 1 | 511 | Gary Peters | Bart Johnson | Gary Peters | Bart Johnson | | 128 | 100 | 28 |
| 1971-05-07 | @ MIL | 25 | W 5-4 | 17-8 | 1 | 7,713 | Ray Culp | Marty Pattin | Bill Lee | Ken Sanders | Sparky Lyle | 133 | 104 | 29 |
| 1971-05-08 | @ MIL | 26 | W 4-2 | 18-8 | 1 | 11,684 | Sonny Siebert | Lew Krausse | Sonny Siebert | Lew Krausse | Ken Tatum | 137 | 106 | 31 |
| 1971-05-09 | @ MIL | 27 | L 1-6 | 18-9 | 1 | 9,050 | Mike Nagy | Bill Parsons | Bill Parsons | Mike Nagy | | 138 | 112 | 26 |
| 1971-05-11 | @ MIN | 28 | W 5-4 | 19-9 | 1 | 6,549 | Gary Peters | Tom Hall | Gary Peters | Tom Hall | Bill Lee | 143 | 116 | 27 |
| 1971-05-12 | @ MIN | 29 | L 0-1 | 19-10 | 1 | 8,643 | Ray Culp | Bert Blyleven | Bert Blyleven | Ray Culp | | 143 | 117 | 26 |
| 1971-05-14 | vs BAL | 30 | W 2-0 | 20-10 | 1 | 33,941 | Sonny Siebert | Jim Palmer | Sonny Siebert | Jim Palmer | | 145 | 117 | 28 |
| 1971-05-15 | vs BAL | 31 | L 4-7 | 20-11 | 1 | 28,480 | Mike Nagy | Dave McNally | Dave McNally | Mike Nagy | Pete Richert | 149 | 124 | 25 |
| 1971-05-17 | vs DET | 32 | W 3-2 | 21-11 | 1 | 14,001 | Ray Culp | Dean Chance | Ray Culp | Dean Chance | Sparky Lyle | 152 | 126 | 26 |
| 1971-05-18 | vs DET | 33 | W 5-3 | 22-11 | 1 | 13,021 | Gary Peters | Bill Zepp | Jim Lonborg | Bill Denehy | | 157 | 129 | 28 |
| 1971-05-19 | vs NYA | 34 | W 7-2 | 23-11 | 1 | 21,077 | Sonny Siebert | Steve Kline | Sonny Siebert | Lindy McDaniel | Sparky Lyle | 164 | 131 | 33 |
| 1971-05-20 | vs NYA | 35 | W 5-2 | 24-11 | 1 | 20,334 | Bill Lee | Stan Bahnsen | Bill Lee | Stan Bahnsen | Bobby Bolin | 169 | 133 | 36 |
| 1971-05-21 | @ BAL | 36 | W 8-4 | 25-11 | 1 | 17,528 | Jim Lonborg | Pat Dobson | Ken Tatum | Dick Hall | | 177 | 137 | 40 |
| 1971-05-22 | @ BAL | 37 | L 2-5 | 25-12 | 1 | 9,855 | Ray Culp | Mike Cuellar | Mike Cuellar | Ray Culp | | 179 | 142 | 37 |
| 1971-05-23 | @ BAL | 38 | L 3-12 | 26-13 | 1 | 0 | Gary Peters | Jim Palmer | Jim Palmer | Gary Peters | | 182 | 154 | 28 |
| 1971-05-23 | @ BAL | 39 | W 2-1 | 26-13 | 1 | 40,267 | Sonny Siebert | Dave McNally | Sonny Siebert | Dave McNally | Sparky Lyle | 184 | 155 | 29 |
| 1971-05-24 | vs WS2 | 40 | L 6-8 | 26-14 | 1 | 14,331 | Bill Lee | Casey Cox | Joe Grzenda | Bobby Bolin | Paul Lindblad | 190 | 163 | 27 |
| 1971-05-25 | vs WS2 | 41 | L 5-6 | 26-15 | 1 | 13,760 | Jim Lonborg | Bill Gogolewski | Casey Cox | Cal Koonce | Paul Lindblad | 195 | 169 | 26 |
| 1971-05-26 | vs WS2 | 42 | W 3-2 | 27-15 | 1 | 13,526 | Ray Culp | Gerry Janeski | Ray Culp | Gerry Janeski | | 198 | 171 | 27 |
| 1971-05-27 | vs WS2 | 43 | W 6-2 | 28-15 | 1 | 14,995 | Gary Peters | Dick Bosman | Gary Peters | Dick Bosman | Bill Lee | 204 | 173 | 31 |
| 1971-05-28 | vs OAK | 44 | W 4-3 | 29-15 | 1 | 35,714 | Sonny Siebert | Vida Blue | Sonny Siebert | Vida Blue | Bobby Bolin | 208 | 176 | 32 |
| 1971-05-29 | vs OAK | 45 | L 8-12 | 29-16 | 1 | 22,572 | Jim Lonborg | Chuck Dobson | Rollie Fingers | Mike Nagy | | 216 | 188 | 28 |
| 1971-05-31 | vs KCA | 46 | L 3-7 | 29-18 | 1 | 0 | Ray Culp | Bruce Dal Canton | Bruce Dal Canton | Ray Culp | Ted Abernathy | 219 | 195 | 24 |
| 1971-05-31 | vs KCA | 47 | L 4-9 | 29-18 | 1 | 31,110 | Gary Peters | Dick Drago | Dick Drago | Gary Peters | Tom Burgmeier | 223 | 204 | 19 |
| 1971-06-01 | vs KCA | 48 | L 2-4 | 29-19 | 1 | 9,816 | Jim Lonborg | Mike Hedlund | Mike Hedlund | Jim Lonborg | | 225 | 208 | 17 |
| 1971-06-02 | @ NYA | 49 | L 1-6 | 29-20 | 2 | 9,306 | Sonny Siebert | Stan Bahnsen | Stan Bahnsen | Sonny Siebert | | 226 | 214 | 12 |
| 1971-06-03 | @ NYA | 50 | W 3-2 | 30-20 | 1 | 15,010 | Ray Culp | Mel Stottlemyre | Ray Culp | Mel Stottlemyre | Bobby Bolin | 229 | 216 | 13 |
| 1971-06-04 | vs CAL | 51 | W 10-1 | 31-20 | 1 | 31,375 | Gary Peters | Andy Messersmith | Gary Peters | Andy Messersmith | | 239 | 217 | 22 |
| 1971-06-05 | vs CAL | 52 | L 2-3 | 31-21 | 2 | 25,764 | Jim Lonborg | Tom Murphy | Tom Murphy | Jim Lonborg | | 241 | 220 | 21 |
| 1971-06-06 | vs CAL | 53 | L 2-5 | 31-22 | 2 | 28,853 | Sonny Siebert | Clyde Wright | Clyde Wright | Sonny Siebert | Dave LaRoche | 243 | 225 | 18 |
| 1971-06-08 | @ OAK | 54 | W 5-1 | 32-22 | 2 | 11,115 | Ray Culp | Blue Moon Odom | Ray Culp | Blue Moon Odom | | 248 | 226 | 22 |
| 1971-06-09 | @ OAK | 55 | L 1-6 | 32-23 | 2 | 8,570 | Gary Peters | Chuck Dobson | Chuck Dobson | Gary Peters | | 249 | 232 | 17 |
| 1971-06-11 | @ KCA | 56 | L 3-6 | 32-24 | 2 | 15,827 | Luis Tiant | Bruce Dal Canton | Bruce Dal Canton | Luis Tiant | Ted Abernathy | 252 | 238 | 14 |
| 1971-06-12 | @ KCA | 57 | L 0-7 | 32-25 | 2 | 21,557 | Jim Lonborg | Dick Drago | Dick Drago | Jim Lonborg | | 252 | 245 | 7 |
| 1971-06-13 | @ KCA | 58 | L 3-4 | 32-26 | 3 | 15,631 | Sonny Siebert | Paul Splittorff | Jim York | Sonny Siebert | Tom Burgmeier | 255 | 249 | 6 |
| 1971-06-14 | @ CAL | 59 | W 4-3 | 33-26 | 3 | 8,410 | Ray Culp | Andy Messersmith | Sparky Lyle | Eddie Fisher | | 259 | 252 | 7 |
| 1971-06-15 | @ CAL | 60 | L 4-5 | 33-27 | 3 | 12,489 | Gary Peters | Tom Murphy | Eddie Fisher | Sparky Lyle | | 263 | 257 | 6 |
| 1971-06-16 | @ CAL | 61 | W 4-1 | 34-27 | 3 | 10,801 | Jim Lonborg | Clyde Wright | Jim Lonborg | Clyde Wright | | 267 | 258 | 9 |
| 1971-06-18 | @ WS2 | 62 | L 5-8 | 34-28 | 3 | 9,420 | Sonny Siebert | Dick Bosman | Dick Bosman | Sonny Siebert | Horacio Pina | 272 | 266 | 6 |
| 1971-06-19 | @ WS2 | 63 | L 0-2 | 34-29 | 3 | 8,954 | Ray Culp | Jackie Brown | Jackie Brown | Ray Culp | Casey Cox | 272 | 268 | 4 |
| 1971-06-20 | @ WS2 | 64 | W 4-3 | 35-29 | 3 | 19,884 | Gary Peters | Pete Broberg | Bobby Bolin | Horacio Pina | | 276 | 271 | 5 |
| 1971-06-22 | vs CLE | 65 | L 3-9 | 36-30 | 3 | 0 | Bill Lee | Steve Hargan | Steve Hargan | Bill Lee | Phil Hennigan | 279 | 280 | -1 |
| 1971-06-22 | vs CLE | 66 | W 2-0 | 36-30 | 3 | 25,578 | Sonny Siebert | Rich Hand | Sonny Siebert | Rich Hand | | 281 | 280 | 1 |
| 1971-06-23 | vs CLE | 67 | W 2-1 | 37-30 | 2 | 17,513 | Ray Culp | Sam McDowell | Ray Culp | Sam McDowell | | 283 | 281 | 2 |
| 1971-06-25 | vs BAL | 68 | L 3-7 | 37-31 | 3 | 31,505 | Jim Lonborg | Pat Dobson | Pat Dobson | Sparky Lyle | Tom Dukes | 286 | 288 | -2 |
| 1971-06-26 | vs BAL | 69 | W 3-2 | 39-31 | 3 | 27,298 | Gary Peters | Mike Cuellar | Gary Peters | Dick Hall | | 289 | 290 | -1 |
| 1971-06-26 | vs BAL | 70 | W 10-2 | 39-31 | 3 | 24,531 | Sonny Siebert | Grant Jackson | Sonny Siebert | Grant Jackson | | 299 | 292 | 7 |
| 1971-06-27 | vs BAL | 71 | W 3-1 | 40-31 | 2 | 29,362 | Ray Culp | Jim Palmer | Ray Culp | Jim Palmer | | 302 | 293 | 9 |
| 1971-06-28 | vs WS2 | 72 | W 10-4 | 41-31 | 2 | 21,000 | Luis Tiant | Jackie Brown | Bobby Bolin | Casey Cox | Ken Tatum | 312 | 297 | 15 |
| 1971-06-29 | vs WS2 | 73 | W 6-2 | 42-31 | 2 | 25,024 | Jim Lonborg | Pete Broberg | Jim Lonborg | Pete Broberg | Sparky Lyle | 318 | 299 | 19 |
| 1971-06-30 | @ DET | 74 | W 6-4 | 43-31 | 2 | 20,528 | Gary Peters | Joe Coleman | Gary Peters | Joe Coleman | Bobby Bolin | 324 | 303 | 21 |
| 1971-07-01 | @ DET | 75 | W 8-7 | 44-31 | 2 | 16,961 | Sonny Siebert | Bill Gilbreth | Bill Lee | Fred Scherman | | 332 | 310 | 22 |
| 1971-07-02 | vs NYA | 76 | L 0-6 | 44-32 | 2 | 29,309 | Ray Culp | Stan Bahnsen | Stan Bahnsen | Ray Culp | | 332 | 316 | 16 |
| 1971-07-03 | vs NYA | 77 | L 1-2 | 44-33 | 2 | 28,878 | Luis Tiant | Fritz Peterson | Fritz Peterson | Luis Tiant | | 333 | 318 | 15 |
| 1971-07-04 | vs NYA | 78 | W 7-4 | 45-33 | 2 | 23,108 | Jim Lonborg | Steve Kline | Bill Lee | Steve Kline | Sparky Lyle | 340 | 322 | 18 |
| 1971-07-05 | vs NYA | 79 | W 12-7 | 46-33 | 2 | 23,364 | Gary Peters | Mel Stottlemyre | Bobby Bolin | Lindy McDaniel | Ken Tatum | 352 | 329 | 23 |
| 1971-07-06 | @ CLE | 80 | W 3-2 | 47-33 | 2 | 9,309 | Sonny Siebert | Ray Lamb | Sonny Siebert | Ray Lamb | Gary Peters | 355 | 331 | 24 |
| 1971-07-07 | @ CLE | 81 | W 4-0 | 48-34 | 2 | 0 | Ray Culp | Alan Foster | Ray Culp | Alan Foster | | 359 | 331 | 28 |
| 1971-07-07 | @ CLE | 82 | L 3-4 | 48-34 | 2 | 8,582 | Luis Tiant | Rich Hand | Ed Farmer | Luis Tiant | Phil Hennigan | 362 | 335 | 27 |
| 1971-07-08 | @ CLE | 83 | W 5-3 | 49-34 | 2 | 8,305 | Jim Lonborg | Steve Hargan | Bill Lee | Vince Colbert | Sparky Lyle | 367 | 338 | 29 |
| 1971-07-09 | @ NYA | 84 | L 2-5 | 49-35 | 2 | 19,016 | Gary Peters | Mel Stottlemyre | Mel Stottlemyre | Gary Peters | | 369 | 343 | 26 |
| 1971-07-10 | @ NYA | 85 | L 3-5 | 49-36 | 2 | 43,433 | Sonny Siebert | Stan Bahnsen | Mike Kekich | Sparky Lyle | | 372 | 348 | 24 |
| 1971-07-11 | @ NYA | 86 | L 2-3 | 49-37 | 2 | 23,104 | Ray Culp | Fritz Peterson | Lindy McDaniel | Ray Culp | | 374 | 351 | 23 |
| 1971-07-15 | vs MIN | 87 | W 3-0 | 50-37 | 2 | 27,673 | Luis Tiant | Jim Perry | Bill Lee | Stan Williams | | 377 | 351 | 26 |
| 1971-07-16 | vs MIN | 88 | W 9-4 | 51-37 | 2 | 29,293 | Sonny Siebert | Bert Blyleven | Sonny Siebert | Bert Blyleven | | 386 | 355 | 31 |
| 1971-07-17 | vs MIL | 89 | W 13-11 | 53-37 | 2 | 0 | Jim Lonborg | Skip Lockwood | Jim Lonborg | Skip Lockwood | Sparky Lyle | 399 | 366 | 33 |
| 1971-07-17 | vs MIL | 90 | W 5-3 | 53-37 | 2 | 27,791 | Ray Culp | Bill Parsons | Ray Culp | Bill Parsons | | 404 | 369 | 35 |
| 1971-07-18 | vs MIL | 91 | L 4-5 | 53-38 | 2 | 22,602 | Gary Peters | Jim Slaton | Jim Slaton | Gary Peters | Ken Sanders | 408 | 374 | 34 |
| 1971-07-20 | vs CHA | 92 | W 5-4 | 54-38 | 2 | 23,373 | Luis Tiant | Steve Kealey | Bobby Bolin | Tom Bradley | | 413 | 378 | 35 |
| 1971-07-21 | vs CHA | 93 | W 6-1 | 55-38 | 2 | 24,946 | Sonny Siebert | Joe Horlen | Sonny Siebert | Joe Horlen | | 419 | 379 | 40 |
| 1971-07-22 | vs CHA | 94 | L 2-4 | 55-39 | 2 | 28,268 | Jim Lonborg | Wilbur Wood | Wilbur Wood | Jim Lonborg | Bart Johnson | 421 | 383 | 38 |
| 1971-07-23 | @ MIN | 95 | W 8-6 | 56-39 | 2 | 19,505 | Ray Culp | Steve Luebber | Ray Culp | Steve Luebber | Sparky Lyle | 429 | 389 | 40 |
| 1971-07-24 | @ MIN | 96 | W 6-3 | 57-39 | 2 | 17,487 | Gary Peters | Jim Perry | Gary Peters | Jim Perry | | 435 | 392 | 43 |
| 1971-07-25 | @ MIN | 97 | L 2-6 | 57-40 | 2 | 16,188 | Luis Tiant | Bert Blyleven | Stan Williams | Luis Tiant | | 437 | 398 | 39 |
| 1971-07-26 | @ MIN | 98 | L 1-2 | 57-41 | 2 | 12,681 | Sonny Siebert | Jim Kaat | Jim Kaat | Sonny Siebert | | 438 | 400 | 38 |
| 1971-07-27 | @ MIL | 99 | W 4-3 | 58-42 | 2 | 0 | Jim Lonborg | Skip Lockwood | Jim Lonborg | Ken Sanders | Sparky Lyle | 442 | 403 | 39 |
| 1971-07-27 | @ MIL | 100 | L 1-5 | 58-42 | 2 | 12,179 | Ray Culp | Bill Parsons | Bill Parsons | Ray Culp | | 443 | 408 | 35 |
| 1971-07-28 | @ MIL | 101 | L 0-5 | 58-43 | 2 | 8,310 | Gary Peters | Jim Slaton | Jim Slaton | Gary Peters | | 443 | 413 | 30 |
| 1971-07-29 | @ MIL | 102 | L 0-3 | 58-44 | 2 | 15,568 | Luis Tiant | Marty Pattin | Marty Pattin | Luis Tiant | | 443 | 416 | 27 |
| 1971-07-30 | @ CHA | 103 | L 1-5 | 58-45 | 2 | 19,693 | Sonny Siebert | Joe Horlen | Joe Horlen | Sonny Siebert | | 444 | 421 | 23 |
| 1971-07-31 | @ CHA | 104 | W 6-0 | 59-45 | 2 | 9,618 | Jim Lonborg | Tommy John | Jim Lonborg | Tommy John | | 450 | 421 | 29 |
| 1971-08-01 | @ CHA | 105 | W 5-1 | 61-45 | 2 | 0 | Ray Culp | Wilbur Wood | Ray Culp | Wilbur Wood | | 455 | 422 | 33 |
| 1971-08-01 | @ CHA | 106 | W 6-1 | 61-45 | 2 | 19,354 | Gary Peters | Vicente Romo | Gary Peters | Vicente Romo | | 461 | 423 | 38 |
| 1971-08-02 | @ BAL | 107 | W 7-4 | 62-45 | 2 | 11,709 | Luis Tiant | Dave Leonhard | Bill Lee | Tom Dukes | | 468 | 427 | 41 |
| 1971-08-04 | @ BAL | 108 | L 4-5 | 62-46 | 2 | 26,849 | Jim Lonborg | Jim Palmer | Pete Richert | Ken Tatum | | 472 | 432 | 40 |
| 1971-08-05 | vs DET | 109 | W 5-4 | 63-46 | 2 | 27,778 | Gary Peters | Les Cain | Gary Peters | Les Cain | Sparky Lyle | 477 | 436 | 41 |
| 1971-08-06 | vs DET | 110 | L 0-2 | 63-47 | 2 | 32,108 | Ray Culp | Joe Coleman | Joe Coleman | Ray Culp | | 477 | 438 | 39 |
| 1971-08-07 | vs DET | 111 | L 8-12 | 63-48 | 2 | 25,857 | Sonny Siebert | Joe Niekro | Joe Niekro | Sonny Siebert | Fred Scherman | 485 | 450 | 35 |
| 1971-08-08 | vs DET | 112 | L 2-8 | 63-49 | 2 | 32,146 | Luis Tiant | Mickey Lolich | Mickey Lolich | Luis Tiant | | 487 | 458 | 29 |
| 1971-08-09 | vs DET | 113 | W 12-11 | 64-49 | 2 | 20,116 | Jim Lonborg | Les Cain | Sparky Lyle | Ron Perranoski | | 499 | 469 | 30 |
| 1971-08-10 | vs OAK | 114 | L 5-6 | 64-51 | 2 | 0 | Gary Peters | Catfish Hunter | Rollie Fingers | Sparky Lyle | | 504 | 475 | 29 |
| 1971-08-10 | vs OAK | 115 | L 5-7 | 64-51 | 2 | 30,004 | Ray Culp | Blue Moon Odom | Blue Moon Odom | Ray Culp | Mudcat Grant | 509 | 482 | 27 |
| 1971-08-11 | vs OAK | 116 | L 3-5 | 64-52 | 2 | 30,481 | Sonny Siebert | Vida Blue | Vida Blue | Roger Moret | Darold Knowles | 512 | 487 | 25 |
| 1971-08-12 | vs OAK | 117 | L 2-9 | 64-53 | 2 | 23,827 | Ken Brett | Diego Segui | Diego Segui | Ken Brett | | 514 | 496 | 18 |
| 1971-08-13 | vs KCA | 118 | L 1-5 | 64-54 | 2 | 22,700 | Jim Lonborg | Dick Drago | Dick Drago | Jim Lonborg | | 515 | 501 | 14 |
| 1971-08-14 | vs KCA | 119 | L 1-6 | 64-55 | 2 | 21,325 | Gary Peters | Al Fitzmorris | Al Fitzmorris | Gary Peters | Jim York | 516 | 507 | 9 |
| 1971-08-15 | vs KCA | 120 | L 1-5 | 64-56 | 3 | 22,453 | Ray Culp | Mike Hedlund | Mike Hedlund | Ray Culp | Tom Burgmeier | 517 | 512 | 5 |
| 1971-08-16 | vs CAL | 121 | W 6-5 | 65-56 | 3 | 17,877 | Sonny Siebert | Tom Murphy | Sparky Lyle | Rudy May | | 523 | 517 | 6 |
| 1971-08-17 | vs CAL | 122 | L 3-4 | 65-57 | 2 | 19,953 | Ken Tatum | Andy Messersmith | Andy Messersmith | Ken Tatum | | 526 | 521 | 5 |
| 1971-08-18 | vs CAL | 123 | W 4-3 | 66-57 | 2 | 25,507 | Jim Lonborg | Clyde Wright | Jim Lonborg | Clyde Wright | Bobby Bolin | 530 | 524 | 6 |
| 1971-08-20 | @ OAK | 124 | W 1-0 | 67-57 | 2 | 31,494 | Gary Peters | Vida Blue | Gary Peters | Vida Blue | | 531 | 524 | 7 |
| 1971-08-21 | @ OAK | 125 | L 1-4 | 67-58 | 2 | 14,987 | Ray Culp | Catfish Hunter | Catfish Hunter | Ray Culp | | 532 | 528 | 4 |
| 1971-08-22 | @ OAK | 126 | L 3-9 | 67-60 | 3 | 0 | Roger Moret | Blue Moon Odom | Blue Moon Odom | Roger Moret | Mudcat Grant | 535 | 537 | -2 |
| 1971-08-22 | @ OAK | 127 | L 1-2 | 67-60 | 3 | 22,923 | Sonny Siebert | Diego Segui | Diego Segui | Sonny Siebert | | 536 | 539 | -3 |
| 1971-08-24 | @ KCA | 128 | L 4-5 | 67-61 | 3 | 9,963 | Jim Lonborg | Dick Drago | Tom Burgmeier | Luis Tiant | | 540 | 544 | -4 |
| 1971-08-25 | @ KCA | 129 | L 5-7 | 67-62 | 3 | 8,101 | Gary Peters | Al Fitzmorris | Lance Clemons | Gary Peters | | 545 | 551 | -6 |
| 1971-08-26 | @ KCA | 130 | W 7-0 | 68-62 | 3 | 9,216 | Ray Culp | Ken Wright | Ray Culp | Ken Wright | | 552 | 551 | 1 |
| 1971-08-27 | @ CAL | 131 | L 0-1 | 68-63 | 3 | 7,897 | Sonny Siebert | Andy Messersmith | Andy Messersmith | Sonny Siebert | Lloyd Allen | 552 | 552 | 0 |
| 1971-08-28 | @ CAL | 132 | W 6-2 | 69-63 | 3 | 13,042 | Roger Moret | Clyde Wright | Roger Moret | Clyde Wright | | 558 | 554 | 4 |
| 1971-08-29 | @ CAL | 133 | L 1-2 | 69-64 | 3 | 6,539 | Jim Lonborg | Rudy May | Rudy May | Jim Lonborg | Lloyd Allen | 559 | 556 | 3 |
| 1971-08-31 | vs BAL | 134 | W 4-3 | 70-64 | 3 | 26,040 | Gary Peters | Jim Palmer | Luis Tiant | Jim Palmer | | 563 | 559 | 4 |
| 1971-09-01 | vs BAL | 135 | L 2-8 | 70-65 | 3 | 23,676 | Ray Culp | Mike Cuellar | Mike Cuellar | Ray Culp | | 565 | 567 | -2 |
| 1971-09-02 | vs BAL | 136 | W 3-0 | 71-65 | 3 | 19,676 | Sonny Siebert | Pat Dobson | Sonny Siebert | Pat Dobson | | 568 | 567 | 1 |
| 1971-09-03 | vs CLE | 137 | W 9-2 | 72-65 | 3 | 16,086 | Roger Moret | Sam McDowell | Roger Moret | Sam McDowell | | 577 | 569 | 8 |
| 1971-09-04 | vs CLE | 138 | L 9-11 | 72-66 | 3 | 16,506 | Jim Lonborg | Rich Hand | Rich Hand | Jim Lonborg | Phil Hennigan | 586 | 580 | 6 |
| 1971-09-05 | vs CLE | 139 | W 8-1 | 73-66 | 3 | 22,820 | Gary Peters | Ed Farmer | Gary Peters | Ed Farmer | | 594 | 581 | 13 |
| 1971-09-06 | @ NYA | 140 | L 3-5 | 73-68 | 3 | 0 | Ray Culp | Steve Kline | Roger Hambright | Ray Culp | | 597 | 586 | 11 |
| 1971-09-06 | @ NYA | 141 | L 0-3 | 73-68 | 3 | 21,490 | John Curtis | Stan Bahnsen | Stan Bahnsen | John Curtis | | 597 | 589 | 8 |
| 1971-09-07 | @ NYA | 142 | W 9-3 | 74-68 | 3 | 14,527 | Sonny Siebert | Fritz Peterson | Sonny Siebert | Fritz Peterson | | 606 | 592 | 14 |
| 1971-09-08 | @ NYA | 143 | L 1-2 | 74-69 | 3 | 6,154 | Roger Moret | Mel Stottlemyre | Roger Hambright | Bobby Bolin | | 607 | 594 | 13 |
| 1971-09-09 | @ DET | 144 | W 12-6 | 75-69 | 3 | 13,775 | Jim Lonborg | Bill Gilbreth | Jim Lonborg | Jack Whillock | | 619 | 600 | 19 |
| 1971-09-10 | @ DET | 145 | W 6-1 | 76-69 | 3 | 18,251 | Gary Peters | Mickey Lolich | Gary Peters | Mickey Lolich | | 625 | 601 | 24 |
| 1971-09-11 | @ DET | 146 | L 0-1 | 76-70 | 3 | 14,694 | Ray Culp | Joe Coleman | Joe Coleman | Ray Culp | | 625 | 602 | 23 |
| 1971-09-12 | @ DET | 147 | L 2-3 | 76-71 | 3 | 12,612 | John Curtis | Les Cain | Tom Timmermann | John Curtis | | 627 | 605 | 22 |
| 1971-09-13 | vs NYA | 148 | L 0-4 | 76-72 | 3 | 12,272 | Sonny Siebert | Stan Bahnsen | Stan Bahnsen | Sonny Siebert | | 627 | 609 | 18 |
| 1971-09-14 | vs NYA | 149 | L 3-6 | 76-73 | 3 | 12,492 | Roger Moret | Mel Stottlemyre | Mel Stottlemyre | Roger Moret | | 630 | 615 | 15 |
| 1971-09-15 | @ CLE | 150 | W 6-5 | 77-73 | 3 | 2,449 | Jim Lonborg | Alan Foster | Sparky Lyle | Ed Farmer | Ken Brett | 636 | 620 | 16 |
| 1971-09-16 | @ CLE | 151 | W 10-7 | 78-73 | 3 | 2,301 | Mike Garman | Rich Hand | John Curtis | Ray Lamb | Sparky Lyle | 646 | 627 | 19 |
| 1971-09-17 | @ WS2 | 152 | W 10-7 | 79-73 | 3 | 3,856 | Ray Culp | Mike Thompson | Bobby Bolin | Casey Cox | | 656 | 634 | 22 |
| 1971-09-18 | @ WS2 | 153 | L 1-6 | 79-74 | 3 | 3,671 | Ken Brett | Bill Gogolewski | Bill Gogolewski | Ken Brett | Joe Grzenda | 657 | 640 | 17 |
| 1971-09-19 | @ WS2 | 154 | W 4-3 | 80-74 | 3 | 4,834 | Roger Moret | Pete Broberg | Roger Moret | Pete Broberg | | 661 | 643 | 18 |
| 1971-09-21 | vs DET | 155 | W 3-2 | 81-74 | 3 | 11,323 | Jim Lonborg | Tom Timmermann | Jim Lonborg | Jack Whillock | | 664 | 645 | 19 |
| 1971-09-22 | vs DET | 156 | W 3-2 | 82-74 | 3 | 10,554 | Mike Garman | Mickey Lolich | Mike Garman | Mickey Lolich | Ken Tatum | 667 | 647 | 20 |
| 1971-09-24 | vs WS2 | 157 | W 4-0 | 83-74 | 3 | 14,351 | Roger Moret | Pete Broberg | Roger Moret | Pete Broberg | | 671 | 647 | 24 |
| 1971-09-25 | vs WS2 | 158 | W 6-3 | 84-74 | 3 | 19,126 | John Curtis | Denny McLain | John Curtis | Denny McLain | | 677 | 650 | 27 |
| 1971-09-26 | vs WS2 | 159 | W 8-1 | 85-74 | 3 | 15,240 | Jim Lonborg | Dick Bosman | Jim Lonborg | Dick Bosman | | 685 | 651 | 34 |
| 1971-09-28 | @ BAL | 160 | L 2-10 | 85-76 | 3 | 0 | Ray Culp | Dave McNally | Dave McNally | Ray Culp | Pat Dobson | 687 | 661 | 26 |
| 1971-09-28 | @ BAL | 161 | L 4-5 | 85-76 | 3 | 18,195 | Gary Peters | Mike Cuellar | Pete Richert | Gary Peters | | 691 | 666 | 25 |
| 1971-09-29 | @ BAL | 162 | L 0-1 | 85-77 | 3 | 21,028 | Mike Garman | Grant Jackson | Grant Jackson | Mike Garman | Eddie Watt | 691 | 667 | 24 |